@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0624: (2015-12-17 )
MLSVIILAAGKGTRMHSSLPKTLHTICGEPMLFYILEVAFSISNDVHLVLHHQQERIKEAVSKRFKGVIFHAQIVEKYSGTGGAIMQENKTPIPTQHERVLILNADMPLITKDALTPLLESHNNAIGLLHLADPKGYGRVILENHQVKKIVEEKDANDEEKTIKSVNAGVYFFERKFLERYLPKLHDQNAQKEYYLTDLIALGIKGNEKIDAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLPSSIYLEKGVSFKGECVLEQGVRLIGNCLIENARIKAYSVIEESQIINSSVGPFAHARPKSVICDSHVGNFVETKNAKLQGTKAGHLSYLGDCEIGKNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRTPQTNIENGYFKFFKKP
Atome Classification :
(41 SA)
--.........10........20........30......-..40.-.-.....-.50........60.....--...70........80......-..90..-.....-.100.......110.......120-..-----..-----.....--130.........140.-.-......150.......160.......170.......180.......190.......200.......210.----..-.-.-..220........230.........240.......250...------------...------------.------------260----.......------..270.....-----..280----...------------------.------------..------------...290..-----.....-300.-----------.------.------.....310..-..-.-.-.-320.......330-.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
L
S
V
I
I
L
AAGKGTR
M
H
SS
L
P
K
T
L
H
T
ICG
E
P
M
L
F
Y
I
L
E
-
V
A
F
SI-S-N
D
V
H
L
-
V
L
H
H
Q
Q
E
R
I
K
E
A
V
S
K
R
F
K
--
G
V
I
F
H
A
Q
I
V
E
K
YSGTGGAIMQ-ENKTPI-PTQH
E
-
R
V
L
I
L
NADMPLI
T
K
D
A
L
T
P
L
L
E
---SH-----NN-----
A
I
G
L
L
--
H
--LADPKGY
G
R
V
I
-L-E-
N
H
Q
V
K
K
I
V
E
EKDAN
D
E
E
K
T
I
K
SVNA
G
V
Y
F
F
E
R
K
F
L
E
R
Y
L
P
K
LHDQNA
Q
K
E
Y
Y
L
T
D
L
I
A
LGIKGNE
K
I
D
A
I
----
F
L-E-E-
E
C
FL-GVNSQ
T
E
R
A
--
K
A
E
E
I
M
L
E
R
L
R
K
NAMD
L
G
V
V
M
QL
P
S
------------
S
I
Y
------------L------------E------KGVSFK
G
------
E
C
V
L
E
Q
G
V
R
L
-----
I
G
N
------
C
L
I------------------E------------NA------------
R
I
K
A
Y
S
V
I-----
E
E
S
Q
I
-I-NS-----------S------V------GPFAHARPK
S
-
V
I
-C-D-S-HVG
N
F
V
ETKN
A
K
L-QGTKAGH
L
S
Y
LGDCEIGKNTNV
G
A
G
V
I
T
CNYDGKK
K
H
Q
T
IIGE
N
V
F
IGSD
S
Q
L
V
A
P
I
NIGS
N
V
L
IGSG
T
T
I
T
K
DIPSGS
L
S
LSRTPQTNIEN
G
Y
F
K
F
FKKP---
25
PsiBlast_CBE
94.98
39%
-114
- C1 -
4AC3
2
GLMU_STRR6
A:
[6-444]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
E
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
-----
K
N
-----
V
A
T
I
L
T
A
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
--
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
D
ID
V
E
I
A
P
E
V
Q
I
E
------
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V
----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
122
Fugue
94.43
40%
-115
- C1 -
1HM9
6
GLMU_STRPN
A:
[11-468]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
P
E
K
T
V
T
-
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
-----
Q
S
E
Q
L
G
T
G
H
A
V
M
M
-
T
-
E
P
I
L
-
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
---
F
H
-----
I
N
H
KNV
A
T
I
L
T
A
--
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
D
F
-
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
I
D
ID
V
E
I
A
P
E
V
Q
I
------------
E
------
A
N
V
I
L
K
G
------
Q
T
K
I
G
A
E
T
V
L
-----
T
N
G
------
T
Y
V
------------------
V
------------
D
S
------------
T
I
G
A
G
A
V
I
-----
T
N
S
M
I
-
E
-
E
S
-----------
S
V
A
D
G
V
T
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
-
G
-
A
-
Q
V
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
KNQ
28
PsiBlast_CBE
94.15
39%
-113
- C1 -
1HM9
6
GLMU_STRPN
A:
[15-453]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
-----
K
N
-----
V
A
T
I
L
T
A
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
D
ID
V
E
I
A
P
E
V
Q
I
E
------
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V
----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
30
PsiBlast_CBE
93.97
39%
-113
- C1 -
1HM8
2
GLMU_STRPN
A:
[15-453]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
-----
K
N
-----
V
A
T
I
L
T
A
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
D
ID
V
E
I
A
P
E
V
Q
I
E
------
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V
----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
26
PsiBlast_CBE
93.88
39%
-116
- C1 -
4AAW
2
GLMU_STRR6
A:
[6-444]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
E
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
-----
K
N
-----
V
A
T
I
L
T
A
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
---
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
D
ID
V
E
I
A
P
E
V
Q
I
E
------
A
N
V
I
L
K
G
Q
T
K
I
G
A
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V
----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
27
PsiBlast_CBE
93.62
39%
-110
- C1 -
1HM9
6
GLMU_STRPN
B:
[15-453]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
FHI
N
H
-----
K
N
-----
V
A
T
I
L
TA
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
DIDVEIAPEVQI
E
------
A
N
V
I
L
K
G
QTKIGA
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
29
PsiBlast_CBE
93.41
39%
-112
- C1 -
1HM8
2
GLMU_STRPN
B:
[15-453]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
FHI
N
H
-----
K
N
-----
V
A
T
I
L
TA
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
DIDVEIAPEVQI
E
------
A
N
V
I
L
K
G
QTKIGA
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
6
PsiBlast_PDB
92.99
39%
-118
- C1 -
4FCE
6
GLMU_YERPE
A:
[11-452]
-----
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
P
L
A
G
K
P
M
V
Q
H
V
I
D
-
A
A
M
K
L
G
A
-
Q
H
V
H
L
-
V
Y
G
H
G
G
E
L
L
K
K
T
-----
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
H
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
D
T
L
Q
R
L
L
A
---
A
K
P----
E
G
-----
G
I
G
L
L
T
V
K
--
L
D
N
P
S
G
Y
G
R
I
V
-
R
-
E
-
N
G
D
V
V
G
I
V
E
H
K
D
A
S
D
A
Q
R
E
I
N
E
I
N
T
G
I
L
V
A
N
G
R
D
L
K
R
W
L
S
L
L
D
N
N
N
A
Q
G
E
F
Y
I
T
D
I
I
A
L
A
H
A
D
G
K
K
I
A
T
V
----
H
P
-
T
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
A
L
E
R
V
F
Q
T
E
Q
A
E
K
L
L
L
A
G
V
M
L
L
D
P
S
RFDLR
G
E
L
T
H
G
R
D
I
T
------------
I
------------
D
------
T
N
V
I
I
E
G
------
H
V
I
L
G
D
R
V
R
I
G
T
G
C
V
L
K
N
------
C
V
I
G
-----------------
D
------------
D
S
------------
E
I
S
P
Y
T
V
L
-----
E
D
A
R
L
D
A
-
N
C
-----------
T
------
V
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
A
-
E
G
A
-
H
V
G
N
F
V
E
I
K
K
A
R
L
G
K
G
S
K
A
G
H
L
S
Y
L
G
D
A
E
I
G
A
G
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
A
N
G
A
T
I
G
A
G
T
T
V
T
R
D
V
A
E
N
E
L
V
I
S
R
V
K
Q
V
H
I
Q
-
G
W
----------
2
PsiBlast_PDB
92.88
38%
-116
- C1 -
2OI5
5
GLMU_ECOLI
A:
[6-452]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
-------
7
PsiBlast_PDB
92.66
39%
-112
- C1 -
2V0H
11
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
33
PsiBlast_CBE
92.61
39%
-109
- C1 -
1G97
3
GLMU_STRPN
A:
[6-444]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
F
H
I
N
H
-----
K
N
-----
V
A
T
I
L
T
A
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
N
D
-
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
------------
D
------
I
D
V
E
I
A
S
------
E
V
Q
I
E
A
N
V
T
L
-----
K
G
Q
------
T
K
I
------------------
G
A
E
T
V
L
T
N
G
T
Y
V
V
D
S
------------
T
I
G
A
G
A
V
I
-----
T
N
S
M
I
-
E
-
E
S
-----------
S
------
V
A
D
G
V
I
V
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
N
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
------------
10
PsiBlast_PDB
92.60
39%
-115
- C1 -
2V0K
11
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
4
PsiBlast_PDB
92.57
38%
-114
- C1 -
2OI7
4
GLMU_ECOLI
A:
[6-452]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
-------
3
PsiBlast_PDB
92.53
38%
-115
- C1 -
2OI6
5
GLMU_ECOLI
A:
[6-453]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
V
------
18
PsiBlast_PDB
92.49
39%
-112
- C1 -
4KPX
11
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
19
PsiBlast_PDB
92.44
39%
-113
- C1 -
4KPZ
11
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
15
PsiBlast_PDB
92.44
39%
-115
- C1 -
4E1K
5
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
31
PsiBlast_CBE
92.40
39%
-114
- C1 -
1HM0
2
GLMU_STRPN
B:
[15-453]
------
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
-
P
E
K
T
V
T
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
Q
T
E
--
F
V
T
Q
S
E
Q
L
-----
G
T
G
H
A
V
M
M
-
T
E
--
P
I
L
E
G
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
FHI
N
H
-----
K
N
-----
V
A
T
I
L
TA
E
--
T
D
N
P
F
G
Y
G
R
I
V
--------
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
-
K
-
D
F
D
E
S
L
-
G
V
N
D
R
V
A
L
A
--
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
DIDVEIAPEVQI
E
------
A
N
V
I
L
K
G
QTKIGA
E
T
V
L
T
N
G
T
Y
V
-----
V
D
S
------
T
I
G
------------------
A
------------
G
A
------------
V
I
-
T
N
S
M
I
-----
E
E
S
S
V
-
A
-
D
G
V----------
T
------
V
------
G
P
Y
A
H
I
R
P
N
S
-
S
L
G
A
-
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
------------
24
PsiBlast_CBE
92.40
38%
-113
- C1 -
1HV9
5
GLMU_ECOLI
B:
[6-452]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
-------
20
PsiBlast_PDB
92.33
39%
-112
- C1 -
4KQL
11
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
17
PsiBlast_PDB
92.22
39%
-113
- C1 -
4KNX
8
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
16
PsiBlast_PDB
92.21
39%
-112
- C1 -
4KNR
9
GLMU_HAEIN
A:
[6-453]
---
L
S
A
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
I
A
G
K
P
M
V
K
H
V
I
D
-
T
A
H
Q
L
G
S
-
E
N
I
H
L
-
I
Y
G
H
G
G
D
L
M
R
T
H
L
A
N
E
Q
V
--
N
W
V
L
Q
T
E
Q
L
----
G
T
A
H
A
V
Q
Q
---
A
A
P
F
-
F
K
D
N
E
-
N
I
V
V
L
Y
G
D
A
P
L
I
T
K
E
T
L
E
K
L
I
E
---
A
K
P----
E
N
-----
G
I
A
L
L
T
V
N
--
L
D
N
P
T
G
Y
G
R
I
I
-
R
-
E
-
N
G
N
V
V
A
I
V
E
Q
K
D
A
N
A
E
Q
L
N
I
K
E
V
N
T
G
V
M
V
S
D
G
A
S
F
K
K
W
L
A
R
V
G
N
N
N
A
Q
G
E
Y
Y
L
T
D
L
I
A
L
A
N
Q
D
N
C
Q
V
V
A
V
Q
A
TD
V
M
-
E
-
V
-
E
----
G
A
N
N
R
L
Q
L
A
--
A
L
E
R
Y
F
Q
N
K
Q
A
S
K
L
L
L
E
G
V
M
I
Y
D
P
A
------------
R
F
D
------------
L
------------
R
G
T
L
E
H
G
K
D
V
E
I
D
V
------
N
V
I
I
E
G
N
V
K
L
G
D
R
V
K
I
G
T
G-----
C
V
L
------------------
K
------------
N
V
V
I
G
N
D
V
------
E
I
K
P
Y
S
V
L
-----
E
D
S
I
V
G
E
-
K
A
-----------
A
------
I
------
G
P
F
S
R
L
R
P
G
A
E
L
A
-
A
-
E
-
T
-
H
V
G
N
F
V
E
I
K
K
S
T
V
G
K
G
S
K
V
N
H
L
T
Y
V
G
D
S
E
I
G
S
N
C
N
I
G
A
G
V
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
K
V
A
N
G
A
T
I
G
A
G
T
T
I
T
R
D
V
G
E
N
E
L
V
I
T
R
V
A
Q
R
H
I
Q
-
G
W
Q
R
P
I
------
23
PsiBlast_CBE
91.90
38%
-113
- C1 -
2OI5
7
GLMU_ECOLI
B:
[6-452]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
-------
21
PsiBlast_CBE
91.76
38%
-112
- C1 -
2OI7
7
GLMU_ECOLI
B:
[6-452]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
-------
40
PsiBlast_CBE
91.45
32%
-114
- C1 -
3ST8
7
GLMU_MYCTU
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G
-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
22
PsiBlast_CBE
91.37
38%
-112
- C1 -
2OI6
7
GLMU_ECOLI
B:
[6-454]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C
----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
G
A
-
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
-
G
W
R
R
P
V
K
-----
34
PsiBlast_CBE
91.23
32%
-110
- C1 -
4K6R
6
GLMU_MYCTO
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G
-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
H
G
S
S
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
121
Fugue
91.22
39%
-110
- C1 -
1HV9
4
GLMU_ECOLI
A:
[4-451]
-N
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
-
G
A
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
--
D
--
N
L
N
W
V
L
Q
--
A
E
Q
L
G
T
G
H
A
M
Q
Q
-
A
A
P
F
F
---
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
-----
P
Q
G
G
I
--
G
L
L
T
V
--
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
Q
R
-
L
-
S
E
V
E
-
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
------------
R
F
D
------------
L
------------
R
------
G
T
L
T
H
G
R
------
D
V
E
I
D
T
N
V
I
I
-----
E
G
N
------
V
T
L
G
H
R
V
K
I
G
T
G
C
V
I
K
N
S
V
I
G
D
------------
D
C
------------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
A
A
C
-----------
T
------
I
------
G
P
F
A
R
L
R
P
G
A
-
E
L
-
L
-
E
-
G
A
H
V
G
N
F
V
E
M
K
K
A
R
L
G
K
G
S
K
A
G
H
L
T
Y
L
G
D
A
E
I
G
D
N
V
N
I
G
A
G
T
I
T
C
N
Y
D
G
A
N
K
F
K
T
I
I
G
D
D
V
F
V
G
S
D
T
Q
L
V
A
P
V
T
V
G
K
G
A
T
I
A
A
G
T
T
V
T
R
N
V
G
E
N
A
L
A
I
S
R
V
P
Q
T
Q
K
E
G
-----
W
R
R
P
---
38
PsiBlast_CBE
91.02
32%
-111
- C1 -
4G3Q
5
GLMU_MYCTU
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G
-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
41
PsiBlast_CBE
90.69
32%
-115
- C1 -
3SPT
5
GLMU_MYCTU
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
G
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
132
HHSearch
90.68
39%
-108
- C1 -
1HM9
6
GLMU_STRPN
A:
[11-464]
--
S
N
F
A
I
I
L
A
A
G
K
G
T
R
M
K
S
D
L
P
K
V
L
H
K
V
A
G
I
S
M
L
E
H
V
F
R
-
S
V
G
A
I
-
Q
P
E
K
T
V
T
-
V
V
G
H
K
A
E
L
V
E
E
V
L
A
G
-----
Q
T
E
F
V
T
Q
S
E
Q
--
L
G
T
G
H
A
V
M
M
T
E
P
I
L
E
G
---
L
S
G
-
H
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
D
---
F
H
I
N
H
KN
V
A
-----
T
I
L
T
A
--
E
--
T
D
N
P
F
G
Y
G
R
I
V
-
R
-
N
D
N
A
E
V
L
R
I
V
E
Q
K
D
A
T
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
F
E
A
L
K
N
I
N
T
N
N
A
Q
G
E
Y
Y
I
T
D
V
I
G
I
F
R
E
T
G
E
K
V
G
A
Y
----
T
L
---
K
-
D
F
D
E
-
S
L
G
V
N
D
R
V
A
L
A
T
A
E
S
V
M
R
R
R
I
N
H
K
H
M
V
N
G
V
S
F
V
N
P
E
------------
A
T
Y
------------
I
------------
D
------
I
D
V
E
I
A
P
------
E
V
Q
I
E
A
N
V
I
L
-----
K
G
Q
------
T
K
I
------------------
G
------------
A
E
T
V
L
T
NG
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
N
S
M
I
E
E
S
S
V
-
A
-
D
G
-----------
V
------
T
V
-----
G
P
Y
A
H
I
R
P
N
S
-
S
L
-
G
A
Q
-
V
-
H
I
G
N
F
V
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
L
G
D
N
S
L
V
G
A
G
S
T
I
T
K
D
V
P
A
D
A
I
A
I
G
R
G
R
Q
I
N
K
D
E
Y
A
T
R
L
P
H
H
P
---
39
PsiBlast_CBE
90.46
32%
-115
- C1 -
4G3P
6
?
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
36
PsiBlast_CBE
90.46
32%
-116
- C1 -
4G87
5
GLMU_MYCTU
A:
[14-470]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
H
G
S
S
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
-----
43
PsiBlast_CBE
90.31
32%
-111
- C1 -
3D8V
1
GLMU_MYCTU
A:
[8-466]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G
-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
Y
D
-
T
S
K
R
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
37
PsiBlast_CBE
89.91
32%
-114
- C1 -
4G3S
7
GLMU_MYCTU
A:
[14-472]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G
-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
H
G
S
S
S
S
I
G
DG
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
35
PsiBlast_CBE
89.57
32%
-114
- C1 -
4HCQ
5
GLMU_MYCTU
A:
[14-470]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
T
L
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
-----
42
PsiBlast_CBE
88.74
32%
-107
- C1 -
3DJ4
3
GLMU_MYCTU
A:
[8-466]
----
A
V
L
V
L
A
A
G
P
G
T
R
M
R
S
D
T
P
K
V
L
H
T
L
A
G
R
S
M
L
S
H
V
L
H
A
I
A
K
L
A
-
P
-
Q
R
L
I
V
-
V
L
G
H
D
H
Q
R
I
A
P
L
V
G
E
L
A
D
TL
G
R
T
I
D
V
A
L
Q
D
R
P
L
G
T
G
H
A
V
L
C
--
G
L
S
A
L
-
P
D
D
Y
A
G
N
V
V
V
T
S
G
D
T
P
L
L
D
A
D
T
L
A
D
L
I
A
---
T
H
R
A
V
--
S
A
-----
A
V
T
V
L
--
T
T
T
L
D
D
P
F
G
Y
G
R
I
L
R
T
-
Q
-
D
H
E
V
M
A
I
V
E
Q
T
D
A
T
P
S
Q
R
E
I
R
E
V
N
A
G
V
Y
A
F
D
I
A
A
L
R
S
A
L
S
R
L
S
S
N
N
A
Q
Q
E
L
Y
L
T
D
V
I
A
I
L
R
S
D
G
Q
T
V
H
A
S
----
H
V
-
D
-
D
-
S
A
L
V
A
G
V
N
N
R
V
Q
L
A
--
E
L
A
S
E
L
N
R
R
V
V
A
A
H
Q
L
A
G
V
T
V
V
D
P
A
------------
T
T
W
------------
I
------------
D
------
V
D
V
T
I
G
R
------
D
T
V
I
H
P
G
T
Q
L
-----
L
G
R
T
Q
I
G
G
R
C
V
V
G-----------------
P
------------
D
T
------------
T
L
T
D
V
A
V
G
-----
D
G
A
S
V
-
V
-
R
T
HGSS
S
S
I
G
D
G
A
A
------
V
------
G
P
F
T
Y
L
R
P
G
T
-
A
L
G
A
-
D
-
G
-
K
L
G
A
F
V
E
V
K
N
S
T
I
G
T
G
T
K
V
P
H
L
T
Y
V
G
D
A
D
I
G
E
Y
S
N
I
G
A
S
S
V
F
V
N
-------
R
T
T
V
G
S
H
V
R
T
G
S
D
T
M
F
V
A
P
V
T
I
G
D
G
A
Y
T
G
A
G
T
V
V
R
E
D
V
P
P
G
A
L
A
V
S
A
G
P
Q
R
N
I
E
N
W
V
Q
R
--
K
R
P
---
47
PsiBlast_CBE
76.48
32%
-127
- C1 -
1FWY
4
GLMU_ECOLI
A:
[6-328]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C----------
T
------
I
------
G
P
----------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
75.52
32%
-128
- C1 -
1FWY
4
GLMU_ECOLI
B:
[6-326]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
TV
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLRGTLTHGR
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
VIGDDC------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C----------
T
------
I
------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
74.86
32%
-124
- C1 -
1FXJ
2
GLMU_ECOLI
A:
[6-329]
---
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
G
A
-
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
A
E
Q
L
----
G
T
G
H
A
M
Q
Q
---
A
A
P
F
-
F
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
P----
Q
G
-----
G
I
G
L
L
T
V
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
-
Q
-
R
-
L
S
E
V
E
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
RFDLR
G
T
L
T
H
G
R
D
V
E
------------
I
------------
D
------
T
N
V
I
I
E
G
------
N
V
T
L
G
H
R
V
K
I
-----
G
T
G
------
C
V
I
------------------
K
------------
N
S
V
I
G
D
D
C
------
E
I
S
P
Y
T
V
V
-----
E
D
A
N
L
-
A
-
A
A
C----------
T
------
I
------
G
P
F
---------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
74.49
31%
-113
- C1 -
1FXJ
2
GLMU_ECOLI
A:
[3-329]
N
N
A
M
S
V
V
I
L
A
A
G
K
G
T
R
M
Y
S
D
L
P
K
V
L
H
T
L
A
G
K
A
M
V
Q
H
V
I
D
-
A
A
N
E
L
-
G
A
A
H
V
H
L
-
V
Y
G
H
G
G
D
L
L
K
Q
A
L
K
D
D
N
L
--
N
W
V
L
Q
----
A
E
Q
L
G
T
G
H
A
M
Q
Q
-
A
A
P
F
F
---
A
D
D
E
-
D
I
L
M
L
Y
G
D
V
P
L
I
S
V
E
T
L
Q
R
L
R
D
---
A
K
-----
P
Q
G
G
I
--
G
L
L
T
V
--
K
--
L
D
D
P
T
G
Y
G
R
I
T
-
R
-
E
-
N
G
K
V
T
G
I
V
E
H
K
D
A
T
D
E
Q
R
Q
I
Q
E
I
N
T
G
I
L
I
A
N
G
A
D
M
K
R
W
L
A
K
L
T
N
N
N
A
Q
G
E
Y
Y
I
T
D
I
I
A
L
A
Y
Q
E
G
R
E
I
V
A
V
----
H
P
Q
R
-
L
-
S
E
V
E
-
G
V
N
N
R
L
Q
L
S
--
R
L
E
R
V
Y
Q
S
E
Q
A
E
K
L
L
L
A
G
V
M
L
R
D
P
A
------------
R
F
D
------------
L
------------
R
------
G
T
L
T
H
G
R
------
D
V
E
I
D
T
N
V
I
I
-----
E
G
N
------
V
T
L
G
-----------------
H
------------
R
V
------------
K
I
G
T
G
C
V
I
-----
K
N
S
V
I
-
G
-
D
-------------------------------------------------------------
D
C
E
I
S
P
Y
T
V
V
E
D
A
N
L
A
A
A
C
T
I
G
P
F
-------------------------------------------------------------------------------