@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0705: (2015-12-17 )
MLVDSFNRVIDYIRVSVTKQCNFRCQYCMPTTPLDFFDDEELLPLDNVLEFLKIAIDEGVKKIRITGGEPLLRKGLDEFIAKLHAYNKEVALVLSTNGFSLKKMAKGLKDAGLSRVNVSLDSLKSDRVLKISQKDALKNTLEGIEESLKVGLKLKLNTVVMKGVNDDEILELLEYAKNRSIQIRYIEFMENTHAKSLVKGLKEKEILDLIAQKYKIMGMEKPKQGSSKIYTLENGYQFGIIAPHSDDFCQSCNRIRLASDGKICPCLYYQDAIDAKEAIINKDTKMMKRLLKQSIINKPEKNMWNDKNGGTPTRAFYYTGG
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------.........10.----.------...-----...20.-..-......30..----..----.----...40-.-.......50.......----.60.---...--.--.--..-70.--.--..---....80....---.---...90........--------100.-.......110......-.120--.-.......130-----.-...-...140........150.......160.--.---..--.-..-170......---.-----180.-.....-------...190.......--..200.........210-.......220--....-....230--..-.....240....-...250...-....----.260......--------.270....------....280..-......290.......300......---------.-310.......320-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------MLV
D
S
F
N
R
V
I
D
Y
----
I
------
R
V
S-----VTKQ-C-N
F
-
R
C
Q
YCMPTTP----LD----F----FDDEE-L-L
P
L
D
N
V
L
E
F
L
K
I
A
I
DE----GV
K
K
---
I
R
I--T--G--G
E
-
P
L
L
--
R
--
K
G
---
L
D
E
F
I
A
K
L
H
A---Y---N
K
E
V
A
L
V
L
STNGF--------
S
L
-
K
-
K
M
A
K
G
L
K
D
AGL
S
R
V
N
V
-
S
L
D
---S-LKSD
R
V
L
K
I
S
-----
Q
-
K
D
A
-
L
K
N
T
-
L
E
G
I
E
E
S
L
KVG
L
K
L
K
L
N
T
V
V
MKG--V---
N
D
--
D
-
E
I
-
L
E
L
L
E
Y
AKN---R-----
S
--
I
-
Q
I
R
Y
I
-------
E
F
M
E--N
T
H
A
K
S
L
--
V
K
G
--
L
K
E
K
E
I
L
D
L
I
A
Q
-
K
Y
K
IMGME-K--PKQG-S
S
K
I
Y
T
L--EN-
G
Y
Q
F
G
I
IAPHS
D
-
D
F
C
Q
S-CN
R
-
I
R
LA----SDG
K
I
C
P
C
L
Y
--------YQ-DAI
D
A
------
K
E
A
I
I-NK
D
-
T
K
M
M
K
R
L
L
K
Q
S
IINKPEKNMWNDKN---------G-GT
P
T
R
A
F
Y
Y
TGG--------------------------------------------
20
HHSearch
93.36
38%
-95
- C4 -
1TV8
5
MOAA_STAA8
A:
[4-329]
----------------------------------------------------------------------------------------------
Q
I
K
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
----
D
DFVF
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
R
N
I
K
-
A
T
T
I
-
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
--
V
G
N
D
N
G
W
DF
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
P
K
--
Y
F
G
E
-
V
A
K
Y
Y
R
H
--
K
D
N
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
V
D
G
F
N
V
------
K
A
F
I
R
-
S
G
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
T
A
Q
T
V
A
-----
N
R
Q
-------------------------------------------------------
46
Fugue
91.52
37%
-93
- C4 -
1TV8
5
MOAA_STAA8
A:
[3-329]
---------------------------------------------------------------------------------------------E
Q
I
K
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
FGDD
F
V
----
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
K
A
T
T
I
-
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
--
V
G
N
D
N
G
W
--
D
F
S
KV
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
E
V
A
K
Y
Y
R
H
--
K
D
N
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
V
D
G
F
N
V
------
K
A
F
I
R
S
G
V
T
-
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
T
A
---------
Q
-
T
V
A
N
R
Q
--------------------------------------------------
19
PsiBlast_CBE
87.89
41%
-98
- C4 -
2FB2
4
MOAA_STAA8
B:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
A
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
HK
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
A
-
A
A
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
16
PsiBlast_CBE
87.61
42%
-100
- C4 -
2FB3
5
MOAA_STAA8
B:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
4
PsiBlast_PDB
87.47
41%
-100
- C4 -
2FB2
4
MOAA_STAA8
A:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
A
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
A
-
A
A
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
2
PsiBlast_PDB
87.46
42%
-100
- C4 -
1TV8
5
MOAA_STAA8
A:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
3
PsiBlast_PDB
87.10
42%
-96
- C4 -
2FB3
6
MOAA_STAA8
A:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
18
PsiBlast_CBE
87.03
42%
-98
- C4 -
1TV7
3
MOAA_STAA8
B:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
1
PsiBlast_PDB
87.02
42%
-94
- C4 -
1TV7
3
MOAA_STAA8
A:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
H
K
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
17
PsiBlast_CBE
86.63
42%
-103
- C4 -
1TV8
4
MOAA_STAA8
B:
[7-280]
-------------------------------------------------------------------------------------------------
D
K
L
G
R
P
I
R
D
----
L
------
R
L
S
-----
V
T
D
R
-
C
-
N
F
-
R
C
D
Y
C
M
P
K
E
V
----
F
G
DDFV
F
----
L
P
K
N
E
-
L
-
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
L
----
G
V
K
K
---
I
R
I
--
T
--
G
--
G
E
-
P
L
M
--
R
--
R
D
---
L
D
V
L
I
A
K
L
N
Q
---
I
---
D
G
I
E
D
I
G
L
T
T
N
G
L
--------
L
L
-
K
-
K
H
G
Q
K
L
Y
D
A
G
L
R
R
I
N
V
-
S
L
D
---
A
-
I
D
D
T
L
F
Q
S
I
N
-----
N
-
R
N
I
-
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
G
L
N
V
K
V
N
V
V
I
Q
K
G
--
I
---
N
D
--
D
-
Q
I
-
I
P
M
L
E
Y
F
K
D
---
K
-----
H
--
I
-
E
I
R
F
I
-------
E
F
M
D
V
G
N
D
N
G
W
D
F
--
S
K
V
--
V
T
K
D
E
M
L
T
M
I
E
Q
-
H
F
E
I
D
P
V
E
-
P
--
K
Y
F
G
-
E
V
A
K
Y
Y
R
HK
D
N
-
G
V
Q
F
G
L
I
T
S
V
S
Q
-
S
F
C
S
T
-
C
T
R
-
A
R
L
S
----
S
D
G
K
F
Y
G
C
L
F
--------
A
T
-
V
D
G
F
N
------
V
K
A
F
I
-
R
S
G
-
V
T
D
E
E
L
K
E
Q
F
K
A
L
W
Q
I
R
D
D
R
Y
S
D
E
R
---------
T
-
A
Q
T
V
A
N
R
Q
------------------------------------------------
53
Fugue
61.14
17%
-38
- C4 -
1R30
5
BIOB_ECOLI
A:
[27-338]
-----------------------------------------------------------------R
P
R
W
T
L
S
Q
V
T
E
L
F
E
KP
L
L
D
L
L
F
E
A
Q
Q
V
H
R
Q
H
F
D
P
R
Q
V
Q
V
S
T
----
L
------
L
S
I
-----
K
T
G
A
-
C
-
P
E
-
D
C
K
Y
C
P
Q
S
S
R
----
Y
K
----
T
G---
L
E
A
E
R
-
L
-
M
E
V
E
Q
V
L
E
S
A
R
K
A
K
A
A
----
G
S
T
R
---
F
C
M
--
G
A
-
A
--
W
K
-
N
P
H
--
E
--
R
D
---
M
P
Y
L
E
Q
M
V
Q
G
---
V
---
K
A
M
G
L
E
A
C
M
T
L
G
T
--------
L
S
-
E
-
S
Q
A
Q
R
L
A
N
A
G
L
D
Y
Y
N
H
-
N
L
D
---
T
--
S
P
E
F
Y
G
N
I
I
-----
T
-
T
R
T
-
Y
Q
E
R
-
L
D
T
L
E
K
V
R
D
A
G
I
K
V
C
S
G
G
I
V
G
L
G
--
E
---
T
V
--
K
-
D
R
-
A
G
L
L
L
Q
L
A
N
---
L
PTPPE
S
--
V
-
P
I
N
M
L
-------
V
K
V
K
--
G
T
P
L
A
D
N
---
D
D
--
V
D
A
F
D
F
I
R
T
I
A
V
-
A
R
I
M
M
P
T
S
-
Y
--
V
R
L
S
-
A
G
R
E
Q
M
N
--
E
Q
-
T
Q
A
M
C
F
M
A
--------------------------
G
A
N
S
I
F
Y
--------
G
C
-
K
L
L
T
T
------
P
N
P
E
E
-
D
K
D
-
L
Q
L
F
R
K
L
---------------------------
G
-
L
N
P
Q
Q
T
--------------------------------------------------
48
Fugue
56.27
16%
-43
- C4 -
4K36
5
ANSME_CLOP1
A:
[2-392]
-----------------------------------------------------------------------------------------------------
P
P
L
S
L
----
L
------
I
K
P
-----
A
S
S
G
-
C
-
N
L
-
K
C
T
Y
C
F
Y
H
S
L
----
S
D
----
N
----
V
K
S
Y
G
-
I
-
M
R
D
E
V
L
E
S
M
V
K
R
V
L
N
E
----
A
N
G
H
---
C
S
F
--
A
F
Q
G
--
G
E
-
P
T
L
AG
L
--
E
F
---
F
E
K
L
M
E
L
Q
R
K
---
H
NYK
N
L
K
I
Y
N
S
L
Q
T
N
G
T
--------
L
I
D
E
-
S
W
A
K
F
L
S
E
N
K
F
-
L
V
G
L
-
S
M
D
GP
K
E
-
I
H
N
L
N
R
K
D
C
C
-----
G
-
L
D
T
-
F
S
K
V
-
E
R
A
A
E
L
F
K
K
Y
K
V
E
F
N
I
L
C
V
V
-
T
S
--
N
---
T
A
--
R
-
H
V
-
N
K
V
Y
K
Y
F
K
E
---
K
-----
D
--
F
K
F
L
Q
F
I
-------
N
C
L
D
--
P
L
Y
E
E
K
G
--
K
Y
N
YS
L
K
P
K
D
Y
T
K
F
L
K
N
-
L
F
D
F
W
Y
E
D
-
F
--
L
N
G
N
-
R
V
S
I
R
Y
F
--
D
G
-
L
L
E
T
I
L
L
G
K
S
S
S
C
G
M
N
G
T
-
C
T
C
Q
F
V
V
E
----
S
D
G
S
V
Y
P
C
D
F
--------
Y
V
-
L
D
K
W
R
------
L
G
N
I
Q
-
D
M
T
-
M
K
E
L
F
E
T
N
K
N
H
E
F
I
K
L
S
F
K
V
H
E
E
C
K
K
CKWFRLCK
G
-
G
C
R
R
C
R
D
S
K
E
D
S
ALELNYY
C
Q
S
Y
K
E
F
F
E
Y
A
F
P
R
L
I
N
V
A
N
N
IV
D
K
L
A
A
A
L
E
H
H
H
HHH
28
HHSearch
54.79
20%
-51
- C4 -
1R30
4
BIOB_ECOLI
A:
[60-272]
-------------------------------------------------------------------------------------------------------
P
R
Q
----
V
------
Q
V
S
T
L
L
SI
K
T
G
A
-
C
-
P
E
-
D
C
K
Y
C
P
Q
S
S
R
----
Y
K
----
T
G---
L
E
A
E
R
-
L
-
M
E
V
E
Q
V
L
E
S
A
R
K
A
K
A
A
----
G
S
T
R
---
F
C
M
--
G
--
A
AW
K
N
-
P
H
E
--
R
D
M
P
Y
---
L
E
Q
M
V
Q
G
V
K
A
---
M
---
G
--
L
E
A
C
-
M
T
L
G
T
--------
L
S
-
E
-
S
Q
A
Q
R
L
A
N
A
G
L
D
Y
Y
N
H
-
N
L
D
---
T
--
S
P
E
F
Y
G
N
I
I
-----
T
-
T
R
T
-
Y
Q
E
R
-
L
D
T
L
E
K
V
R
D
A
G
I
K
V
C
S
G
G
I
V
G
L
G
--
E
---
T
V
--
K
-
D
R
-
A
G
L
L
L
Q
L
A
N
---
L
-----
P
TP
P
E
S
V
P
I
N
-------
M
L
V
K
--
V
K
G
T
P
L
A
D-
N
D
D
--
V
D
A
F
D
F
I
R
T
I
A
V
-
A
R
I
M
M
P
T
S
-
Y
--
V
R
L
S
-
A
G
R
E
Q
M
N
--
E
Q
-
T
Q
A
M
C
F
M
A
G
A
N
S
-
I
F
Y
G
C
-
K
L
L
-
T
T
P
N
----
P
E
E
D
K
D
L
Q
L
F
--------
R
K
-
L
G
L
N
P
------
Q
Q
T
---------------------------------------------------------------------------------------------------
52
Fugue
49.33
15%
-52
- C4 -
2A5H
8
KAMA_CLOSU
A:
[3-411]
NRRYELFKDVS
D
A
D
W
N
D
W
R
W
Q
V
R
N
RIET
V
E
E
L
K
K
Y
I
P
L
T
K
E
E
E
E
G
V
A
Q
CVK
S
L
R
M
A
I
T
P
Y
Y
L
S
L
IDPNDPND
P
V
R
K
Q
A
IPTALELNKAAADLED
P
L
H
E
D
T
D
S
P
V
P
G
----
L
THRYPD
R
V
L
-----
L
L
I
T
-
D
M
C
S
M
Y
C
R
H
C
T
R
R
R
F
----
A
G
----
Q
-----
S
D
D
S
M
P
M
E
R
I
D
K
A
I
D
Y
I
R
N
--
T
P
----
Q
V
R
D
---
V
L
L
--
S
--
G
--
G
D
-
A
L
L
VS
D
--
E
T
---
L
E
Y
I
I
A
K
L
R
E
---
I
---
P
H
V
E
I
V
R
I
G
S
R
T
P
--------
V
V
------------
L
P
Q
R
I
T
P
-
E
L
V
---
N
M
L
K
K
Y
H
P
V
W
L
N
T
H
F
NH
P
-
N
E
I
-
T
E
E
S
-
T
R
A
C
Q
L
L
A
D
A
G
V
P
L
G
N
Q
S
V
L
L
R
G
--
V
---
N
D
--
C
V
H
V
M
K
E
L
V
N
K
L
V
K
---
I
-----
R
--
V
-
R
P
Y
Y
I
-------
Y
Q
C
D
--
L
S
L
G
L
E
H
--
F
R
---
T
P
V
S
K
G
I
E
I
I
E
G
L
R
G
H
T
S
G
Y
C
-
V
--
P
------------------
T
F
V
V
D
A
P
G
G
G
-
G
K
T
P
V
M
P
N
Y
-
V
I
S
Q
----
S
H
D
K
V
I
L
R
N
F
--------
E
G
-
V
I
T
T
Y
------
S
E
P
I
N
-
Y
T
P
-
G
C
N
C
D
V
C
T
G
K
K
K
V
H
K
V
G
V
A
G
L
L
N
G
E
---------
G
M
A
L
E
P
V
G
L
E
R
N
K
---------------------------------------------
21
HHSearch
49.25
13%
-57
- C4 -
2A5H
6
KAMA_CLOSU
A:
[113-369]
------------------------------------------------------------------------------------------------------
Y
P
D
R
----
V
------
L
L
L
-----
I
T
D
M
-
C
-
S
M
-
Y
C
R
H
C
T
R
R
R
F
----
A
G
----------
Q
S
D
D
-
S
-
M
P
M
E
R
I
D
K
A
I
D
Y
I
R
N
T
P---
Q
V
R
D
---
V
L
L
--
S
--
G
--
G
D
-
A
L
L
--
V
--
S
D
E
T
-
L
E
Y
I
I
A
K
L
R
E
---
I
---
P
---
H
V
E
I
V
R
I
G
S
RTPVVLPQ
R
I
-
T
P
E
L
V
N
M
L
K
K
Y
H
P
V
W
L
N
T
-
H
F
N
---
H
-
P
N
E
I
-----------------
T
E
E
S
-
T
R
A
C
Q
L
L
A
D
A
G
V
P
L
G
N
Q
S
V
L
L
R
G
VN
D
---
C
V
--
H
-
V
M
-
K
E
L
V
N
K
L
V
K
---
I
-----
R
--
V
R
P
Y
Y
I
Y
-------
Q
C
D
L
--
S
L
G
L
E
H
F
----
R
--
T
P
V
S
K
G
I
E
I
I
E
G
-
L
R
G
H
T
S
G
Y
------
C
V
-
P
T
F
V
V
D
A
--
P
G
G
G
G
K
T
P
V
-
M
P
N
Y
V
-
I
S
Q
S
H
-
D
K
V
-
I
L
R
N
----
F
E
G
V
I
T
T
Y
S
E
--------
P
I
-
N
Y
T
P
G
------
C
N
C
D
V
-
C
T
G
-
K
K
K
V
H
K
V
G
V
A
G
L
L
N
G
E
G
M
A
L
E
P
V
G
L
---------
E
-
R
N
K
-----------------------------------------------------
51
Fugue
47.97
19%
-45
- C4 -
3C8F
3
PFLA_ECOLI
A:
[1-245]
-------------------------------------------------------------------------------------------S
V
I
G
R
I
H
S
F
E
S
C
G
T
V
DGP
G
I
------
R
F
I
-----
T
F
F
Q
G
C
-
L
M
-
R
C
L
Y
C
H
N
R
D
T
----
W
D
----
T
----
H
G
G
K
E
-
V
--
T
V
E
D
L
M
K
E
V
V
T
Y
R
H
F
----
M
N
A
S
G
G
G
V
T
A
--
S
--
G
--
G
E
-
A
I
L
--
Q
--
A
E
---
F
V
R
D
W
F
R
A
C
K
-------
K
E
G
I
H
T
C
L
D
T
N
G
F
VRR-----
Y
D
-
P
-
V
I
D
E
L
L
E
V
T
D
L
V
M
L
D
L
K
Q
M
N
---
D
-
E
I
H
Q
N
L
V
G
V
S
-----
N
------
H
R
T
-
L
E
F
A
K
Y
L
A
N
K
N
V
K
V
W
I
R
Y
V
V
V
P
G
--
W
---
S
D
D
D
D
-
S
A
-
H
R
L
G
E
F
T
R
D
---
M
-----
G
----
N
V
E
K
I
-------
E
L
L
P
------------------------------
Y
H
E
L
G
K
H
-
K
--
W
V
A
-----------------------------------------------------
M
G
--------
E
E
-
Y
K
L
D
G
------
V
K
P
P
K
-
K
E
T
-
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
V
M
F
---------------------------------------------------------------------------
34
HHSearch
47.06
13%
-88
- C4 -
3IVS
1
HOSM_SCHPO
A:
[57-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
F
D
T
E
K
K
I
Q
I
A
K
A
L
D
N
F
----
G
V
D
Y
---
I
E
L
--
T
--
S
-----
P
V
A
--
S
--
E
Q
---
S
R
Q
D
C
E
A
I
C
K
---
L
---
G
--
L
K
C
K
I
L
T
H
I
R
--------
C
H
-
M
-
D
D
A
R
V
A
V
E
T
G
V
D
G
V
D
V
-
V
I
G
---
T
------------------
T
Y
I
-
I
D
S
A
-
T
E
V
I
N
F
V
K
S
K
G
I
E
V
R
F
S
S
E
D
S
F
R
--
S
---
D
L
--
V
-
D
L
-
L
S
L
Y
K
A
V
D
K
---
I
-----
G
--
V
-
N
R
V
G
I
-------
A
D
T
V
--
G
C
A
T
P
R
Q
--
V
Y
D
--
L
I
R
T
L
R
G
V
V
S
C
D
-
I
E
C
H
F
H
N
D
-
T
--
G
M
A
I
-
A
N
A
Y
C
A
L
--
E
A
-
G
A
T
H
I
D
T
S
I
L
G
I
-
G
E
R
N
G
-
I
T
P
-
L
G
A
L
----
L
A
R
M
Y
V
T
D
R
E
--------
Y
I
-
T
H
K
Y
K
------
L
N
Q
L
R
-
E
L
E
-
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
---------
K
-
A
G
I
H
A
K
A
I
L
A
N
P
--------------------------------------------
47
Fugue
46.79
13%
-48
- C4 -
4M7T
5
BTRN_BACCI
A:
[21-270]
---------------------------------------------------------------------------------------------------
M
D
K
L
F
S
M
----
I
------
E
V
E
-----
V
N
S
Q
-
C
-
N
R
-
T
C
W
Y
C
P
N
S
V
S
----
K
R
----------
K
E
T
G
-
E
-
M
D
P
A
L
Y
K
T
L
M
E
Q
L
S
S
L
----
D
F
A
G
---
R
I
S
F
H
F
--
Y
--
G
E
-
P
L
L
--
C
--
K
N
---
L
D
L
F
V
G
M
T
T
E
---
Y
---
I
P
R
A
R
P
I
I
Y
T
N
G
D
--------
F
L
T
E
-
K
R
L
Q
T
L
T
E
L
G
I
Q
K
F
I
V
-
T
Q
H
---
A
-
G
A
K
H
K
F
R
G
V
Y
-----
D
-
Q
-------------------------------------------------
L
A
G
A
D
K
---
E
-----
K
--
V
-
V
Y
L
D
H
-------
S
D
L
V
--
L
S
N
R
G
G
I
--
L
D
N
--
I
P
A
N
M
S
C
M
V
P
S
N
-
L
A
V
V
--------------------------
T
V
L
G
N
V
L
P
C
F
E
-
D
F
-
N
Q
-
K
M
V
-
M
G
N
I
----
G
E
Q
H
I
S
D
I
W
H
--------
N
D
-
K
F
T
S
F
------
R
K
M
L
K
-
E
G
H
-
R
G
K
S
D
L
C
K
N
C
N
N
V
S
V
Q
T
E
E
Q
Y
D
Y
V
L
-------------------------------------------------------------------
26
HHSearch
45.90
11%
-64
* C4 *
3T7V
3
PYLB_METBF
A:
[61-262]
--------------------------------------------------------------------------------------------------------
L
N
----
C
------
F
I
Y
-----
F
S
T
Y
-
C
-
K
N
-
Q
C
S
F
C
Y
Y
N
C
R
----
N
E
----------
I
N
R
Y
-
R
-
L
T
M
E
E
I
K
E
T
C
K
T
L
K
G
A
----
G
F
H
M
---
V
D
L
--
T
--
M
--
G
E
D
P
Y
Y
--
Y
--
E
D
P
N
R
F
V
E
L
V
Q
I
V
K
E
---
E
---
L
G
-
L
P
I
M
I
-
S
P
G
---------
L
M
-
D
N
A
T
L
L
K
A
R
E
K
G
A
N
F
L
A
L
-
Y
Q
E
---
T
-
Y
D
T
E
L
Y
R
K
L
R
-----
V
-
G
Q
S
-
F
D
G
R
-
V
N
A
R
R
F
A
K
Q
Q
G
Y
C
V
E
D
G
I
L
T
G
V
G
--
N
---
D
I
--
E
-
S
T
-
I
L
S
L
R
G
M
S
T
---
N
-----
D
--
P
D
M
V
R
V
M
-------
T
F
L
P
--
Q
E
G
T
P
L
E
G-
F
R
D
--
K
S
N
L
S
E
L
K
I
I
S
V
-
L
R
L
M
F
P
K
R
-
L
--
I
P
A
S
-
L
D
L
E
G
I
D
--
G
M
-
V
L
R
L
N
A
G
A
N
I
V
T
-
S
I
L
P
P
-
D
S
Q
-
L
E
G
V
----
A
N
Y
D
R
D
L
E
E
R
--------
D
R
-
D
I
K
S
V
------
V
R
R
L
E
-
I
M
G
-
M
K
P
A
R
Q
A
D
F
E
A
V
L
-------------------------------------------------------------------------------
50
Fugue
45.67
10%
-45
- C4 -
1OLT
3
HEMN_ECOLI
A:
[4-444]
------------------------------------------------------------QQ
I
D
W
D
LALIKYYTSYPTALEFSEDFG
E
Q
A
F
L
Q
A
V
A
R
Y
P
E
R
P
L
S
L
Y
----
V
------
H
I
P
-----
F
C
H
K
------
L
C
Y
F
C
G
C
N
K
I
----
V
T
----
R
----
Q
Q
H
K
A
-
D
-
Q
Y
L
D
A
L
E
Q
E
I
V
H
R
A
P
L
FAGR
H
V
S
Q
---
L
H
W
--
G
--
G
--
G
T
-
P
T
Y
LN
K
--
A
Q
---
I
S
R
L
M
K
L
L
R
E
N
F
Q
F
---
N
A
D
A
E
I
S
I
E
V
D
P
R
--------
E
I
E
L
-
D
V
L
D
H
L
R
A
E
G
F
N
R
L
S
M
-
G
V
Q
---
D
-
F
N
K
E
V
Q
R
L
V
N
-----
R
-
E
Q
D
-
E
E
F
I
-
F
A
L
L
N
H
A
R
E
I
G
F
T
-
S
T
N
I
D
L
I
Y
G
--
L
PKQ
T
P
--
E
-
S
F
-
A
F
T
L
K
R
V
A
E
L
NP
D
-----
R
--
L
-
S
V
F
N
Y
AHLPTIF
A
A
Q
R
--
K
I
K
D
A
D
L
--
P
S
P
--
Q
Q
K
L
D
I
L
Q
E
T
I
A
-
F
L
T
Q
S
G
Y
Q
-
F
IG
M
D
H
F
-
A
R
P
D
D
E
L
--
A
V
-
A
Q
R
E
G
V
L
H
R
N
F
Q
-
G
Y
T
T
Q
-
G
D
T
-
D
L
L
G
M
G
V
S
A
I
S
M
I
G
D
C
Y
A
Q
N
QKE
L
K
Q
Y
Y
-
Q
Q
V
D
E
QGNALW
R
G
I
A
L
-
T
R
D
-
D
C
I
R
R
D
V
I
K
S
L
I
C
N
F
R
L
D
Y
S
P
I
E
Q
Q
---------
W
-
D
L
L
F
A
D
Y
F
A
E
D
L
K
L
L
A
P
L
A
K
D
GL
V
D
V
D
EK
G
I
Q
V
T
AKGRLL
I
R
N
I
C
M
C
F
DTYL----