@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0782: (2015-12-18 )
MKVYPQVLSIAGSDSGGGAGIQADLKAFQTFGVFGTSVITCITAQNTQGVHGVYPLSVESVKAQILAIRDDFSIKAFKMGALCNAQIIECVANALETCDFGLCVLDPVMVAKNGALLLEEEAILSLKKRLLPKTNLLTPNLPEVYALTGVQARDDKSASKAMGVLRDLGVKNAVIKGGHTEHFQGEFSNDWVFLEDAEFILSAKRFNTKNTHGTGCTLSSLIVGLLAQGLDLKNAITKAKELLTIIIQNPLNIGHGHGPLNLWSIKKHV
Atome Classification :
(26 SA)
.........10........20........30........40.-...--...--.50........60....---....70........80........90.......--.100.........110.......120.......130.......140....-...-150-.--..-..--....160....-...----170.......180.......190..-..--...200.--...-...210.......220.......230.......240.....--..250-...--------.....260-.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKV
Y
P
Q
V
L
S
IAGSDSGGGA
G
I
Q
A
D
L
K
A
F
Q
T
FGVFG
T
S
V
I
T
C
I
-TAQ--NTQ--GVH
G
V
Y
P
L
S
V
E
S
V
K
A
Q
I
---
L
A
IRDDF
S
I
K
A
F
KMGA
L
C
N
A
Q
I
I
E
C
V
A
N
A
L
E
T
C--D
F
--
G
L
C
V
L
D
P
V
MVAKN
G
A
L
L
L
E
E
E
A
I
L
S
L
K
K
R
LLPKTNLLTPNLP
E
V
Y
A
-LTG-V---Q--AR-DD--K
S
A
S
K
A
M
G
V
L
R
-DLG----VKN
A
V
IKGGHTEHFQGEFSN
D
W
V
F
L-ED--
A
E
F
I
L
S
A
--KRF-NTKNTHGTG
C
T
L
S
S
L
I
V
G
L
L
AQGL
D
L
K
N
A
I
T
K
A
K
E
L
L
T
I
I
I--QNPL--NIG--------HGHGPL
N
L
-
W
S
IKKHV
71
HHSearch
90.22
49%
-104
- C1 -
1UB0
7
?
A:
[1-256]
---
M
R
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
-
T
A
Q
--
N
T
L
--
G
V
Q
R
V
H
L
L
P
P
E
V
V
Y
A
Q
I
---
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
F
--
G
V
--
R
P
L
V
V
D
P
V
M
---------
A
K
E
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
-
L
L
G
-
R
---
P
--
I
R
-
T
L
--
K
E
A
E
E
A
A
K
A
L
L
-
A
L
G
----
P
K
A
V
L
L
K
G
G
H
L
-----
E
A
-
V
D
L
L
A
T
-
R
G
--
G
V
L
R
F
S
A
--
P
R
V
-
H
T
R
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
--
K
T
A
P
--
S
L
G
--------
H
G
H
G
P
L
D
H
-
W
A
-----
1
PsiBlast_PDB
87.44
42%
-112
- C1 -
1JXH
2
THID_SALTY
A:
[29-282]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
---
H
--
A
R
-
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
------------
D
W
L
F
T
-
R
E
--
G
E
Q
R
F
-----
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
T
L
--
E
V
G
--------
K
G
I
G
P
V
H
H
-
F
H
A
W
W
--
22
PsiBlast_CBE
87.40
42%
-112
- C1 -
1JXH
2
THID_SALTY
B:
[29-282]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
---
H
--
A
R
-
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
------------
D
W
L
F
T
-
R
E
--
G
E
Q
R
F
-----
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
AQ
A
D
T
L
--
E
V
G
--------
K
G
I
G
P
V
H
H
-
F
H
A
W
W
--
73
HHSearch
86.67
39%
-110
- C1 -
1JXH
2
THID_SALTY
A:
[23-288]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
-
L
L
D
-
A
---
P
--
H
A
R
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
------------
D
W
L
F
T
-
R
E
--
G
E
Q
R
F
-----
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
--
A
Q
A
D
T
L
E
V
G
--------
K
G
I
G
P
V
H
H
F
H
A
W
W
---
21
PsiBlast_CBE
86.13
42%
-104
- C1 -
1JXI
3
THID_SALTY
B:
[29-282]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
---
H
--
A
R
-
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
------------
D
W
L
F
T
-
R
E
--
G
E
Q
R
F
-----
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
AQ
A
D
T
L
--
E
V
G
--------
K
G
I
G
P
V
H
H
-
F
H
A
W
W
--
2
PsiBlast_PDB
85.44
42%
-103
- C1 -
1JXI
3
THID_SALTY
A:
[29-282]
-------
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
A
K
S
G
D
P
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
A
-
P
---
H
--
A
R
-
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
------------
D
W
L
F
T
-
R
E
--
G
E
Q
R
F
-----
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
A
D
T
L
--
E
V
G
--------
K
G
I
G
P
V
H
H
-
F
H
A
W
W
--
4
PsiBlast_PDB
84.86
47%
-107
- C1 -
1UB0
7
?
A:
[18-258]
--------------------
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
-
T
A
Q
--
N
T
L
--
G
V
Q
R
V
H
L
L
P
P
E
V
V
Y
A
Q
I
---
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
F
--
G
V
--
R
P
L
V
V
D
P
V
M
---------
A
K
E
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
-
L
L
G
-
R
---
P
--
I
R
-
T
L
--
K
E
A
E
E
A
A
K
A
L
L
-
A
L
G
----
P
K
A
V
L
L
K
G
G
H
L
------
E
A
V
D
L
L
A
T
-
R
G
--
G
V
L
R
F
S
A
--
P
R
V
-
H
T
R
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
--
K
T
A
P
--
S
L
G
--------
H
G
H
G
P
L
D
H
-
W
A
-----
61
Fugue
84.83
39%
-97
- C1 -
1JXH
2
THID_SALTY
A:
[23-288]
M
Q
-
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
-
V
A
E
--
N
T
C
--
G
V
Q
S
V
Y
R
I
E
P
D
F
V
A
A
Q
L
---
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
V
--
R
N
V
V
L
D
T
V
M
L
------
L
L
S
P
S
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
-
L
L
D
A
P
---
H
--
A
R
-
T
E
--
Q
E
M
L
A
Q
G
R
A
L
L
-
A
M
G
----
C
E
A
V
L
M
K
G
D
W
L
F
T
R
E
G
E
Q
R
F
--------------------
R
V
-
N
T
K
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
--
A
Q
A
D
T
L
E
V
G
--------
K
G
I
G
P
V
H
H
-
F
H
A
W
W
--
23
PsiBlast_CBE
82.04
40%
-121
- C1 -
4JJP
1
?
B:
[12-246]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
-
T
A
Q
--
N
T
K
--
G
V
F
A
V
E
D
L
N
K
K
I
I
K
K
Q
I
---
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
Y
--
N
P
--
K
Y
L
V
V
D
P
V
M
I
-----
Y
L
L
K
P
E
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
-
I
T
G
-
I
---
K
--
I
H
-
N
V
--
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
----
P
K
F
V
L
M
K
G
G
---------
A
V
D
I
L
V
G
-
K
N
--
I
F
K
V
Y
K
S
--------------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
------------------------------------
74
HHSearch
81.56
33%
-97
- C1 -
2I5B
1
PDXK_BACSU
A:
[3-267]
---
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
-
V
A
M
--
D
P
N
NS
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
---
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
--
Q
L
--
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
-
L
S
G
-
M
---
D
--
E
L
K
T
V
--
D
D
M
I
E
A
A
K
K
I
H
-
A
L
G
----
A
Q
Y
V
V
I
T
G
G
G
K
L
K
H
E
-
K
A
-
V
D
V
L
Y
D
-
G
E
--
T
A
E
V
L
E
S
--
E
M
I
-
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
--
K
E
S
F
--
P
L
N
--------
Q
Y
V
G
P
T
K
H
-
S
A
L
R
L
N
Q
12
PsiBlast_PDB
81.09
31%
-103
- C1 -
3RM5
1
THI20_YEAST
A:
[23-291]
----
P
T
V
L
S
I
A
G
T
D
P
S
G
G
A
G
I
E
A
D
V
K
T
I
T
A
H
R
C
Y
A
M
T
C
I
T
A
L
-
N
A
Q
--
T
P
V
--
K
V
Y
S
I
N
N
T
P
K
E
V
V
F
Q
T
L
---
E
S
N
L
K
D
M
K
C
N
V
I
K
T
G
M
L
-
T
A
A
A
I
E
V
L
H
E
K
L
L
Q
L
GE
N
R
--
P
K
L
V
V
D
P
V
L
---------
G
K
D
I
V
S
L
I
T
E
K
V
A
P
F
A
D
I
L
T
P
N
I
P
E
C
Y
K
-
L
L
G
-----
E
--
E
R
-
K
V
--
N
G
L
Q
D
I
F
Q
I
A
K
-
D
L
A
K
I
T
K
C
S
N
I
L
V
K
G
G
H
-----
E
K
Y
I
T
D
V
L
F
L
G
A
E
--
Q
K
F
I
I
F
K
--
G
N
F
V
N
T
T
H
T
H
G
T
G
C
T
L
A
S
A
I
A
S
N
L
A
R
G
Y
S
L
P
Q
S
V
Y
G
G
I
E
Y
----
V
--
Q
N
A
V
--
A
I
G
CDVTKETV
K
D
N
G
P
I
N
H
-
V
Y
A
V
E
I
P
3
PsiBlast_PDB
80.55
40%
-115
- C1 -
4JJP
-
?
A:
[12-248]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
-
T
A
Q
--
N
T
K
--
G
V
F
A
V
E
D
L
N
K
K
I
I
K
K
Q
I
---
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
Y
--
N
P
--
K
Y
L
V
V
D
P
V
M
I
S
K
S
G
Y
Y
L
L
K
P
E
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
-
I
T
G
-
I
---
K
--
I
H
-
N
V
--
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
----
P
K
F
V
L
M
K
G
G
---
H
L
D
G
E
-
A
V
D
I
L
V
G
-
K
N
--
I
F
K
V
Y
K
S
--
E
-----------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
I
--
K
--------------------------------
5
PsiBlast_PDB
80.46
35%
-97
- C1 -
2I5B
1
PDXK_BACSU
A:
[5-259]
-----
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
-
V
A
M
D
P
N
N
S
--
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
---
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
--
Q
L
--
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
-
L
S
G
-
M
DEL
K
--
T
V
-
D
D
M
I
E
A
A
K
K
----
I
H
-
A
L
G
----
A
Q
Y
V
V
I
T
G
G
G
--
K
L
K
H
E
K
A
V
D
V
L
Y
D
-
G
E
--
T
A
E
V
L
E
S
--
E
M
I
-
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
--
K
E
S
F
--
P
L
N
--------
Q
Y
V
G
P
T
K
H
-
S
A
L
R
L
N
Q
30
PsiBlast_CBE
80.26
32%
-99
- C1 -
4C5N
4
?
B:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
-------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
26
PsiBlast_CBE
80.15
35%
-96
- C1 -
2I5B
1
PDXK_BACSU
C:
[5-259]
-----
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
-
V
A
M
D
P
N
N
S
--
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
---
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
--
Q
L
--
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
-
L
S
G
-
M
DEL
K
--
T
V
-
D
D
M
I
E
A
A
K
K
----
I
H
-
A
L
G
----
A
Q
Y
V
V
I
T
G
G
G
--
K
L
K
H
E
K
A
V
D
V
L
Y
D
-
G
E
--
T
A
E
V
L
E
S
--
E
M
I
-
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
--
K
E
S
F
--
P
L
N
--------
Q
Y
V
G
P
T
K
H
-
S
A
L
R
L
--
36
PsiBlast_CBE
80.07
32%
-99
- C1 -
4C5K
5
?
D:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
ETA
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
24
PsiBlast_CBE
79.81
35%
-98
- C1 -
2I5B
1
PDXK_BACSU
E:
[5-259]
-----
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
-
V
A
M
DP
N
N
S
--
W
N
H
Q
V
F
P
I
D
T
D
T
I
R
A
Q
L
---
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
K
--
Q
L
--
K
N
V
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
E
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
-
L
S
G
-
M
DEL
K
--
T
V
-
D
D
MI
E
A
A
K
K
----
I
H
-
A
L
G
----
A
Q
Y
V
V
I
T
G
G
G
--
K
L
K
H
E
K
A
V
D
V
L
Y
D
-
G
E
--
T
A
E
V
L
E
S
--
E
M
I
-
D
T
P
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
--
K
E
S
F
--
P
L
N
--------
Q
Y
V
G
P
T
K
H
-
S
A
L
R
L
N
-
41
PsiBlast_CBE
79.53
32%
-98
- C1 -
4C5J
4
?
B:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
D
E
V
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
11
PsiBlast_PDB
79.48
35%
-115
- C1 -
4YL5
2
?
A:
[9-245]
--
V
R
P
T
V
L
C
F
S
G
L
D
P
S
G
G
A
G
L
Q
A
D
I
E
A
I
G
Q
S
G
A
H
A
A
I
A
C
T
A
L
-
T
I
Q
--
N
S
Q
--
Q
V
F
G
F
E
A
T
S
K
E
L
L
L
A
Q
A
---
N
A
V
V
G
D
L
P
I
K
C
V
K
S
G
M
L
G
T
T
D
N
I
A
A
L
A
E
F
L
R
A
H
--
P
D
--
Y
Q
Y
V
L
D
P
V
L
V
A
N
S
G
G
S
L
G
D
Q
A
T
L
V
K
A
F
V
E
L
I
P
L
A
T
L
I
T
P
N
T
V
E
L
R
A
-
L
T
G
-
V
---
T
--
D
L
-
D
-------
Q
A
T
Q
K
L
F
-
E
M
G
----
A
K
A
V
L
V
K
G
G
H
E
D
--
T
P
D
F
I
K
N
S
L
Y
I
--
D
--
G
E
L
A
A
S
S
T
C
P
------------
C
S
L
A
S
F
I
A
G
R
L
A
L
G
D
S
L
K
I
A
V
Q
H
A
E
T
W
L
F
G
V
------------------------------------
75
HHSearch
79.46
30%
-104
- C1 -
3RM5
2
THI20_YEAST
A:
[20-296]
-
E
K
L
P
T
V
L
S
I
A
G
T
D
P
S
G
G
A
G
I
E
A
D
V
K
T
I
T
A
H
R
C
Y
A
M
T
C
I
T
A
L
-
N
A
Q
--
T
P
V
--
K
V
Y
S
I
N
N
T
P
K
E
V
V
F
Q
T
L
---
E
S
N
L
K
D
M
K
C
N
V
I
K
T
G
M
L
T
A
-
A
A
I
E
V
L
H
E
K
L
L
Q
L
--
G
E
NR
P
K
L
V
V
D
P
V
L
---------
G
K
D
I
V
S
L
I
T
E
K
V
A
P
F
A
D
I
L
T
P
N
I
P
E
C
Y
K
-
L
L
G
-
E
---
E
R
K
V
N
-
G
L
--
Q
D
I
F
Q
I
A
K
D
L
A
K
I
T
K
----
C
S
N
I
L
V
K
G
G
H
----
E
K
Y
I
-
T
D
V
L
F
L
-
G
A
EQ
K
F
I
I
F
K
G
--
N
F
V
-
N
T
T
H
T
H
G
T
G
C
T
L
A
S
A
I
A
S
N
L
A
R
G
Y
S
L
P
Q
S
V
Y
G
G
I
E
Y
V
Q
N
A
V
--
A
I
G
C
--
D
V
T
KETV----
K
D
N
G
P
I
N
H
-
V
Y
A
V
E
I
P
28
PsiBlast_CBE
78.84
32%
-98
- C1 -
4C5N
5
?
D:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
ETA
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
-------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
10
PsiBlast_PDB
78.68
32%
-101
- C1 -
4C5N
2
?
A:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
--------
L
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
29
PsiBlast_CBE
77.88
32%
-97
- C1 -
4C5N
4
?
C:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
---------
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
Q
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
8
PsiBlast_PDB
76.53
32%
-93
- C1 -
4C5L
3
?
A:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
K
G
E
----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
--------
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
---
S
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
34
PsiBlast_CBE
76.47
32%
-92
* C1 *
4C5L
2
?
D:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
ETA
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E
35
PsiBlast_CBE
75.12
32%
-91
- C1 -
4C5L
1
?
C:
[5-259]
-----
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
D
--
K
D
T
--
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
I
G
P
D
----
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
S
--
N
A
--
Q
Y
F
V
V
D
P
V
M
V
C
K
G
-----
N
P
G
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
-
L
S
G
-
L
---
G
--
K
L
-
N
S
I
-
E
D
M
K
K
A
A
T
I
I
F
-
D
K
G
----
A
Q
H
V
I
I
K
G
G
K
A
--
L
D
Q
D
K
S
Y
D
L
Y
Y
D
-
G
Q
--
T
F
Y
Q
L
T
T
--
D
M
F
-
Q
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
--
K
N
G
W
--
K
M
N
--------
D
F
V
G
P
V
D
H
-
G
A
Y
N
R
I
E