@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1400: (2015-12-23 )
MHTVLQIGAGGVGSVVAHKMGMNRDVFKNIILASRSLDKCHAIKESMLKKGLGEIGVEQVDADDTQALIALIQKHKPKVVVNVALPYQDLTIMQACLETKTHYIDTANYEHPDLAKFEYKEQWAFDKAYKEAGILGVLGAGFDPGVTNAYVAHAQRHHFDTIHTLDILDCNAGDHKRPFATNFNPEINLREVSSKGRYYENGKWIETKPLEIKQVWAYPQIGEMDSYLLYHEELESLVKNVKGLRRARFFMTFSQNYLTHMKCLENVGMLGIKEIEHQGVKIVPIQFLKTLLPDPESLAKDTTGKTNIGCYMTGIKNNQDKTLYIYNVCDHKKCYEEVGSQAISYTTGVPAMCAAKMICNDTWSVEHFKAGVFNVEELNTDPFMEELIKQGLPYEVIER
Atome Classification :
(20 SA)
-------.........10....-.-...20.----------------------....-...30-......---..40.-.......50..-----------.....----------------.60....-....70........80.....-..-.---90----.----..-......100.......-110..-------------------..--...120.......130.......140-...--.....150.......----160-----------------------...------------------....-------..170...-----.---..--.180--------.......190.......200.-------------------......210.----.----...--------...-220---------..--.......230--.......240..---.---....250......-..260........270.......280----------------------------------------------------------.......290---------------------------------------------------------.----.......300.....------------------------------------------------------..310-...-..-..320----.........330.......340.......350.....-..360.......370...-..-..380---.......-.390.......--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------M
H
T
V
L
Q
IGAG
G
V
G
S
V
-
V
-
A
H
KMGM----------------------
N
R
D
V
-
F
K
N
I
I
-
L
ASRS
L
---
D
K
C
H
A
-
I
K
E
S
M
L
K
K
G
L
G
-----------EIGVE----------------QVDAD
D
T
-
Q
A
L
I
A
L
I
Q
KHK
P
K
V
V
V
N
V
ALP-Y
Q
-
D
---
L
-----
T
----
I
M
-
Q
A
C
L
E
TKT
H
Y
I
DTANY-EHPD
L
-------------------
A
K
--
F
E
Y
K
E
QWA
F
D
K
A
Y
K
EAG
I
L
G
V
LGAG--FDP--GV
T
N
A
Y
V
A
H
A
QRHHF----D-------------------------
T
I
H
------------------
T
L
D
I
-------
L
DCNAGDH-----K---RP--FATN--------FNP
E
I
N
L
R
EVSSKGRYYEN
G
K
-------------------
W
I
ETKP
L
-
E
I
----
K
----
Q
V
W--------AYP-Q-----------IG--E
M
D
S
Y
L
L
Y
H
E
--
E
L
E
S
L
V
K
N
V
K
G
L
---
R
---
R
A
R
F
F
-
M
T
F
S
Q
N
Y
-
L
T
H
-
M
K
C
L
E
N
VGML
G
I
K
E
I
EHQG
V
K
I
----------------------------------------------------------
V
P
I
Q
F
L
K
T
L----------------------------------------------------------L----P
D
P
E
S
L
A
KDTTGK
T
N
------------------------------------------------------
I
G
C
Y
M
-TGI-KN-NQD------
K
T
L
Y
I
Y
NVC
D
H
K
K
C
Y
E
E
VG
S
Q
A
I
SYTTG
V
P
A
M
C
A
A
K
M
-
I
CNDTW
S
V
E
H
F
KAGVF
N
V
-
E
E-LNT
D
----
P
F
M
E
E
L
I
-KQGL
P
Y
E
V
IER--------------------------------
2
PsiBlast_PDB
93.66
54%
-103
- C2 -
4RL6
1
?
A:
[4-413]
----------
L
L
V
I
G
C
G
G
V
A
Q
V
-
A
-
I
S
K
I
C
Q
----------------------
D
S
E
T
-
F
T
E
I
M
-
I
A
S
R
T
K
---
S
K
C
D
D
-
L
K
A
K
L
E
G
K
T
S
T
-----------
K
I
E
T
A
----------------
A
L
D
A
D
K
V
-
E
E
V
I
A
L
I
G
S
Y
K
P
E
A
V
L
N
V
A
L
P
-
Y
Q
-
D
---
L
-----
T
----
I
M
-
D
A
C
L
A
T
G
V
H
Y
I
D
T
A
N
Y
-
E
A
E
D
T
ED
P
E
W
R
A
I
Y
E
K
R
C
K
E
LGFT
A
Y
--
F
D
Y
S
W
Q
W
A
Y
Q
E
K
F
K
E
A
G
L
T
A
L
L
G
S
G
--
F
D
P
--
G
V
T
S
V
F
S
A
Y
A
L
K
H
Y
F
----
D
-------------------------
E
I
H
------------------
Y
I
D
I
-------
L
D
C
N
G
G
D
H
-----
G
---
Y
P
--
F
A
T
N
--------
F
N
P
E
I
N
L
R
E
V
S
A
P
G
S
Y
W
E
D
G
K
-------------------
W
V
E
V
E
A
M
-
S
I
----
K
----
R
E
Y
--------
D
F
P
-
Q
-----------
V
G
--
Q
K
D
M
Y
L
L
H
H
E
--
E
I
E
S
L
A
K
N
I
P
G
V
---
K
---
R
I
R
F
F
-
M
T
F
G
Q
S
Y
-
L
T
H
-
M
K
C
L
E
N
V
G
L
L
R
T
D
T
I
N
F
----
I
----------------------------------------------------------
V
P
I
Q
F
L
K
A
L
----------------------------------------------------------
L
----
P
D
P
A
S
L
G
P
R
T
V
G
K
T
N
------------------------------------------------------
I
G
C
I
F
-
T
G
V
-
K
D
-
G
V
E
------
K
T
I
Y
I
Y
N
V
C
D
H
Q
E
C
Y
A
E
V
G
S
Q
A
I
S
Y
T
T
G
V
P
A
M
I
G
T
K
L
-
V
M
N
G
T
W
K
----
Q
A
G
V
Y
N
L
-
E
E
-
L
D
P
D
----
P
F
M
E
A
L
N
-
E
Y
G
L
P
W
V
V
V
E
N
--------------------------------
14
HHSearch
63.97
18%
-78
- C2 -
2AXQ
4
LYS9_YEAST
A:
[23-466]
-------
G
K
N
V
L
L
L
G
S
G
F
V
A
Q
P
-
V
-
I
D
T
L
A
A
----------------------
N
D
D
---
I
N
V
T
-
V
A
C
R
T
L
---
A
N
A
Q
A
-
L
A
K
P
S
G
-----------------
S
K
A
I
----------------
S
L
D
V
T
D
D
-
S
A
L
D
K
V
L
A
--
D
N
D
V
V
I
S
L
I
P
Y
-
T
F
-
H
---
P
-----
N
----
V
V
-
K
S
A
I
R
T
K
T
D
V
V
T
S
S
Y
I
-
S
P
------------------------------
A
L
R
E
L
E
P
E
I
V
K
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
V
K
T
I
D
-
E
V
H
R
A
G
G
-------------------------
K
L
K
------------------
S
F
L
S
-------
Y
C
G
G
L
P
A
P
EDSDN
P
---
L
G
--
Y
K
F
S
--------
W
S
S
R
G
V
L
L
A
L
R
N
S
A
K
Y
W
K
D
G
K
-------------------
I
E
T
V
S
S
E
-
D
L
MAT
A
K
----
P
Y
F
--------
I
Y
P
-------------
G
Y
--
A
F
V
C
Y
P
N
R
D
S
--
T
L
F
K
D
L
Y
H
I
P
E
A
---
E
---
T
V
I
R
G
-
T
L
R
Y
Q
G
F
-
P
E
F
-
V
K
A
L
V
D
M
G
M
L
K
D
D
A
N
E
I
F
S
K
P
I
----------------------------------------------------------
A
W
N
E
A
L
K
Q
Y
L
GAKSTS
K
E
D
L
I
A
S
I
D
S
K
ATWKD
D
E
D
R
E
R
I
L
S
G
F
A
W
L
GLFSDAKITPRGN
A
L
D
T
L
C
A
R
L
----
E
E
L
M
Q
Y
E
D
N
E
R
D
M
V
V
------------------------------------------------------
L
Q
H
K
F
G
I
E
W
-
A
D
-
G
T
T
------
E
T
R
T
S
-
T
L
V
D
Y
G
---
K
V
G
G
Y
S
S
M
A
A
T
V
G
Y
P
V
A
I
A
T
K
F
-
V
L
D
G
T
I
K
G
----
P
G
L
L
A
P
-
Y
S
P
E
I
N
D
----
P
I
M
K
E
L
K
D
K
Y
G
I
Y
L
K
E
K
T
V
--------------------------------
15
HHSearch
63.29
17%
-84
- C2 -
3ABI
2
?
A:
[17-364]
--------
M
K
V
L
I
L
G
A
G
N
I
G
R
A
-
I
-
A
W
D
L
K
D
----------------------
E
F
-----
D
V
Y
-
I
G
D
V
N
N
---
E
N
L
E
K
-
V
K
E
F
-------------------
A
T
P
L
----------------
K
V
D
A
S
N
F
-
D
K
L
V
E
V
M
K
--
E
F
E
L
V
I
G
A
L
P
G
-
F
L
-
G
---
F
-----
K
----
S
I
-
K
A
A
I
K
S
K
V
D
M
V
D
V
S
F
M
-
P
E
------------------------------
N
P
L
E
L
R
D
E
A
E
K
A
Q
V
T
I
V
F
D
A
G
--
F
A
P
--
G
L
S
N
I
L
M
G
R
I
F
Q
-
E
L
----
D
--------------------------
L
K
------------------
E
G
Y
I
-------
Y
V
G
G
L
P
K
D
-----
P
K
P
P
L
Y
--
Y
K
I
T
--------
W
S
P
R
D
L
I
E
E
Y
T
R
P
A
R
V
I
R
N
G
K
-------------------
V
S
K
V
D
P
L
-
S
E
----
V
----
K
K
V
--------
K
I
G
-------------
K
----
F
E
F
E
A
F
I
S
D
--
G
L
R
S
M
L
E
T
I
N
-
S
---
E
---
R
L
E
E
W
-
T
L
R
W
P
G
H
-
L
E
K
-
I
K
V
L
R
E
L
G
F
F
K
P
E
N
L
D
--------------------------------------------------------------------
F
T
L
R
V
----------------------------------------------------------
I
----
E
P
L
M
R
Y
--
E
T
K
D
F
S
I
------------------------------------------------------
M
K
V
V
G
-
K
G
E
-
E
--
G
E
-------
M
E
F
F
L
Y
---
D
E
E
----
D
S
M
F
S
S
M
S
R
V
T
G
F
T
A
A
I
I
S
R
I
-
V
A
E
N
T
C
T
-----
F
G
V
I
P
P
-
E
I
L
G
M
R
E
D
T
F
R
R
I
I
D
E
L
K
-
E
R
G
I
S
I
E
G
-----------------------------------
3
PsiBlast_PDB
63.04
19%
-66
- C2 -
3ABI
2
?
A:
[19-363]
----------
V
L
I
L
G
A
G
N
I
G
R
A
-
I
-
A
W
D
L
K
D
----------------------
E
F
D
V
-
Y
I
G
D
V
--
N
N
E
N
L
---
E
K
V
K
E
-
F
A
T
P
L
--------------------------------------
K
V
D
A
S
N
F
-
D
K
L
V
E
V
M
K
E
F
E
---
L
V
I
G
A
L
P
G
F
L
-
G
---
F
-----
K
----
S
I
-
K
A
A
I
K
S
K
V
D
M
V
D
V
S
F
M
P
E
N
P
-------------------------
L
E
L
R
-----
D
E
A
E
K
-
A
Q
V
T
I
V
F
D
A
G
--
F
A
P
--
G
L
S
N
I
L
M
G
R
I
F
-
Q
E
L
----
D
-------------------------
L
K
E
------------------
G
Y
I
Y
-------
V
G
G
L
P
K
D
P
-----
K
---
P
P
LY
Y
K
I
T
--------
W
S
P
R
D
L
I
E
E
Y
T
R
P
A
R
V
I
R
N
G
K
-------------------
V
S
K
V
D
P
L
S
E
V
----
K
----
K
V
-------------
K
-----------
I
G
--
K
F
E
F
E
A
F
I
S
D
--
G
L
R
S
M
L
E
T
I
N
S
E
---
R
---
L
E
E
W
T
-
L
R
W
P
-
G
H
-
L
E
K
-
I
K
V
L
R
E
L
G
F
F
K
P
E
N
L
D
F
T
L
R
V
I
----------------------------------------------------------
E
P
L
M
R
Y
E
T
-----------------------------------------------------------------------
K
D
F
S
I
M
K
V
------------------------------------------------------
V
G
K
G
E
-
E
G
-------
E
------
M
E
F
F
L
Y
D
E
E
D
S
M
-------
F
S
S
M
S
R
V
T
G
F
T
A
A
I
I
S
R
I
-
V
A
E
N
T
C
T
F
G
V
I
P
P
E
I
L
G
M
-
R
E
-
D
T
F
R
----
R
I
I
D
E
L
K
-
E
R
G
I
S
I
E
G
-----------------------------------
35
Fugue
62.24
17%
-80
- C2 -
1E5Q
2
LYS9_MAGO7
A:
[2-450]
------A
T
K
S
V
L
M
L
G
S
G
F
V
T
R
P
-
T
-
L
D
V
L
T
D
----------------------
S
G
I
----
K
V
T
-
V
A
C
R
T
L
---
E
S
A
K
K
-
L
S
A
-----
G
V
Q
-----------
H
S
T
P
I
----------------
S
L
D
V
N
D
D
-
A
A
L
D
A
E
V
A
K
H
D
--
L
V
I
S
L
I
P
Y
-
T
F
-
H
---
A
-----
T
----
V
I
-
K
S
A
I
R
Q
K
K
H
V
V
T
T
S
-------------------------------
Y
V
S
P
A
M
M
E
L
D
Q
A
A
K
D
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
I
K
T
I
E
E
V
H
----
A
-------------------------
A
G
G
------------------
K
I
K
T
-------
F
L
S
Y
C
G
G
L
-----
P
---
A
P
--
E
S
S
D
NPLGYKFS
W
S
S
R
G
V
L
L
A
L
R
N
A
A
S
F
Y
K
D
G
K
-------------------
V
T
N
V
A
G
P
-
E
L
----
M
----
A
T
A
--------
K
P
Y
-
F
-----------
I
Y
--
P
G
F
A
F
V
A
Y
P
N
--
R
D
S
T
P
Y
K
E
R
Y
Q
I
PEA
D
---
N
I
V
R
G
-
T
L
R
Y
Q
G
F
-
P
Q
F
-
I
K
V
L
V
D
I
G
F
L
S
D
E
E
Q
P
F
L
K
E
A
I
----------------------------------------------------------
P
W
K
E
A
T
Q
K
I
----------------------------------------------------------
V
KASS
A
S
E
Q
D
I
V
S
T
I
V
S
N
A
T
FES
T
E
E
Q
K
R
I
V
A
G
L
K
W
L
GIFSDKKITPRGN
A
L
D
T
L
C
A
T
L
E
E
K
MQFEEG
E
R
D
L
V
M
L
Q
H
K
F
-
E
I
E
-
N
K
-
D
G
S
------
R
E
T
R
T
S
S
L
C
E
Y
G
A
P
I
G
S
G
G
Y
S
A
M
A
K
L
V
G
V
P
C
A
V
A
V
K
F
-
V
L
D
G
T
I
S
----
D
R
G
V
L
A
P
-
M
N
-
S
K
I
N
----
D
P
L
M
K
E
L
-
K
E
K
Y
G
I
E
C
K
E
K
V
VA-----------------------------
13
HHSearch
61.06
19%
-75
- C2 -
1FF9
3
LYS9_MAGO7
A:
[3-449]
-------
T
K
S
V
L
M
L
G
S
G
F
V
T
R
P
-
T
-
L
D
V
L
T
D
----------------------
S
-
G
---
I
K
V
T
-
V
A
C
R
T
L
---
E
S
A
K
K
-
L
S
A
G
V
Q
----------------
H
S
T
P
I
----------------
S
L
D
V
N
D
D
-
A
A
L
D
A
E
V
A
--
K
H
D
L
V
I
S
L
I
P
---
F
-
H
---
A
-----
T
----
V
I
-
K
S
A
I
R
Q
K
K
H
V
V
T
T
S
Y
V
-
S
P
------------------------------
A
M
M
E
L
D
Q
A
A
K
D
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
I
K
T
I
E
-
E
V
----
H
A
A
GG---------------------
K
I
K
------------------
T
F
L
S
-------
Y
C
G
G
L
P
A
P
ESSDN
P
---
L
G
--
Y
K
F
S
--------
W
S
S
R
G
V
L
L
A
L
R
N
A
A
S
F
Y
K
D
G
K
-------------------
V
T
N
V
A
G
P
-
E
L
----
M
A
T
A
K
P
Y
F
--------
I
Y
P
-------------
G
F
--
A
F
V
A
Y
P
N
R
D
S
--
T
P
Y
K
E
R
Y
Q
I
P
E
A
---
D
---
N
I
V
R
G
-
T
L
R
Y
Q
G
F
-
P
Q
F
-
I
K
V
L
V
D
I
G
F
L
S
D
E
E
Q
P
F
L
K
E
A
I
P
W
K
E
A
T
Q
K
I
V
KASSAS
E
Q
D
I
V
S
T
I
V
S
N
ATFES
T
E
E
Q
K
R
I
V
A
G
L
K
W
L
GIFSDKKITPRG
N
A
L
D
T
L
C
A
T
----------------------------------------------------------
L
----
E
E
K
M
Q
F
E
E
G
E
R
D
L
V
M
------------------------------------------------------
L
Q
H
K
F
-
E
I
E
N
K
D
-
G
S
R
------
E
T
R
T
-
S
S
L
C
E
Y
G
A
P
I
G
S
G
G
Y
S
A
M
A
K
L
V
G
V
P
C
A
V
A
V
K
F
-
V
L
D
G
T
I
S
D
----
R
G
V
L
A
P
-
M
N
S
K
I
N
D
----
P
L
M
K
E
L
K
E
K
Y
G
I
E
C
K
E
K
V
V
--------------------------------
1
PsiBlast_PDB
59.64
67%
10
- C2 -
4INA
-
?
A:
[4-394]
----------
V
L
Q
I
G
A
G
G
V
G
G
V
-
V
-
A
H
K
M
A
M
----------------------
N
R
E
V
-
F
S
H
I
T
-
L
A
S
R
T
L
---
S
K
C
Q
E
-
I
A
Q
S
I
K
A
K
G
Y
G
-----------
E
I
D
I
T
----------------
T
V
D
A
D
S
I
-
E
E
L
V
A
L
I
N
E
V
K
P
Q
I
V
L
N
I
A
L
P
-
Y
Q
-
D
---
L
-----
T
----
I
M
-
E
A
C
L
R
T
G
V
P
Y
L
D
T
A
N
Y
-
E
H
P
D
L
-------------------
A
K
--
F
E
Y
K
E
Q
W
A
F
H
D
R
Y
K
E
K
G
V
M
A
L
L
G
S
G
--
F
D
P
--
G
V
T
N
V
F
C
A
Y
A
Q
K
H
Y
F
----
D
-------------------------
E
I
H
------------------
E
I
D
I
-------
L
D
C
N
A
G
D
H
-----
G
---
Y
P
--
F
A
T
N
--------
F
N
P
E
I
N
L
R
E
V
S
S
K
G
R
Y
W
E
N
G
E
-------------------
W
I
E
T
E
P
M
-
E
I
----
M
----
Q
V
W
--------
D
Y
P
-
E
-----------
V
G
--
P
K
D
S
Y
L
L
Y
H
E
--
E
L
E
S
L
V
R
N
I
K
G
L
---
K
---
R
I
R
F
F
-
M
T
F
G
Q
S
Y
-
L
T
H
-
M
R
C
L
E
N
V
G
M
L
R
I
D
E
I
E
V
N
G
C
K
V
----------------------------------------------------------
V
P
I
Q
V
L
K
A
L
----------------------------------------------------------
L
----
P
D
P
A
S
L
A
S
R
T
K
G
K
T
N
------------------------------------------------------
I
G
C
Y
I
-
K
G
I
-
K
E
-
G
K
A
------
R
T
I
Y
I
Y
N
V
C
D
H
E
S
C
Y
R
E
V
N
A
Q
A
I
S
Y
T
T
G
V
P
A
M
I
G
A
K
L
-
M
L
E
G
K
W
S
----
G
K
G
V
F
N
M
-
E
E
-
L
D
P
D
----
P
F
M
D
E
L
N
-
K
Q
G
L
P
W
E
V
K
E
M
--------------------------------
36
Fugue
52.54
13%
-52
- C2 -
2PH5
2
?
A:
[6-474]
NTK
K
I
L
F
K
N
R
F
V
I
L
G
F
G
C
V
G
Q
A
-
L
M
P
L
I
F
E
K
----------------------
F
D
I
K
-
P
S
Q
V
T
-
I
I
A
A
E
G
---
T
K
------
V
D
V
A
Q
Q
Y
G
V
-----------
S
F
K
L
Q
----------------
Q
I
T
P
Q
N
Y
-
L
E
V
I
G
S
T
L
E
-
E
N
D
F
L
I
D
V
S
I
G
-
I
S
-
S
---
L
-----
A
----
L
I
-
I
L
C
N
Q
K
G
A
L
Y
I
N
A
A
T
--
E
P
W
K
E
-------------------
R
R
--
T
N
Y
S
L
R
E
E
V
L
R
L
K
D
K
T
Q
K
T
A
L
I
T
H
G
--
A
N
P
--
G
L
V
S
H
F
I
K
E
A
L
L
N
I
A
----
K
D
N
G
L
T
I
N
RPKN
A
A
E
W
A
N
L
A
M
T
L
GIK
V
I
H
------------------
V
A
E
Q
-------
D
S
Q
V
T
Y
P
P
-----
K
---
S
P
G
E
F
V
N
T
--------
W
S
A
N
G
L
I
L
E
G
L
Q
P
A
E
I
G
W
G
T
H
EAHWPHD
A
Y
S
H
SNGPQC
A
I
Y
L
S
R
P
S
A
-
G
V
M
---
V
----
R
S
W
--------
T
-
P
-
T
-----------
L
G
--
A
F
H
G
F
L
I
T
H
A
--
E
T
I
S
L
T
N
F
L
T
L
K
---
N
---
G
S
E
L
L
-
Y
R
P
T
V
H
Y
-
A
Y
N
----
P
C
P
D
A
R
L
S
I
F
E
L
K
S
N
E
W
K
------------------------------------------------------------
P
Q
N
K
N
R
L
I
----------------------------------------------------------
L
----
N
E
------
I
I
D
G
C
D
E
------------------------------------------------------
L
G
V
L
L
M
G
------
N
Q
R
------
G
A
Y
W
Y
G
S
T
L
S
I
Q
E
A
R
Q
I
A
P
Y
N
N
------
A
T
S
L
Q
V
V
A
S
M
I
S
G
I
I
W
A
I
E
H
P
D
E
G
I
V
E
P
-
E
E
-
V
D
H
Q
----
Y
I
I
D
I
A
K
-
P
Y
L
G
K
V
G
G
Y
Y
T
DWTPLKNRGELYPEEVDLSDPWQFFNIRVNLE
5
PsiBlast_PDB
49.29
25%
-116
- C2 -
1E5Q
2
LYS9_MAGO7
A:
[5-133]
---------
S
V
L
M
L
G
S
G
---
F
V
-
T
-
R
P
T
L
D
V
----------------------
L
T
D
S
-
G
I
K
V
T
-
V
A
C
R
T
L
---
E
S
A
K
K
------
L
S
A
G
V
Q
-----------
H
S
T
P
I
----------------
S
L
D
V
N
D
D
-
A
A
L
D
A
E
V
A
K
H
D
--
L
V
I
S
L
-
I
P
-
Y
T
F
H
---
A
-----
T
----
V
I
-
K
S
A
I
R
Q
K
K
H
V
V
-
T
T
S
Y
-
V
S
P
A
M
-------------------
M
E
--
L
--------
D
Q
A
A
K
D
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
I
K
T
I
E
E
V
H
----
A
-------------------------
A
G
G
------------------
K
I
K
T
-------
F
L
S
Y
C
G
G
L
-----
P
---
A
P
--
E
S
S
D
--------
N
P
L
G
Y
K
F
S
W
S
S
R
G
V
L
L
A
L
R
N
A
-------------------
A
S
F
Y
K
D
G
-
K
V
----
T
----
N
V
A
--------
G
P
E
-
L
-----------
M
A
--
T
A
K
P
Y
F
I
Y
P
G
--
F
A
F
V
A
Y
P
N
R
D
S
T
---
P
---
Y
K
E
R
Y
-
Q
I
P
E
A
D
N
-
I
V
R
-
G
T
L
R
Y
Q
G
F
P
Q
F
I
K
V
L
V
D
I
G
F
L
S
----------------------------------------------------------
D
E
E
Q
P
F
L
K
E
----------------------------------------------------------
A
----
I
P
W
K
E
A
T
Q
K
I
V
K
A
S
S
------------------------------------------------------
A
S
E
Q
D
-
I
V
S
-
T
I
-
V
S
N
------
A
T
F
E
S
T
E
E
Q
K
R
I
V
A
G
L
K
W
L
G
I
F
S
D
K
K
I
T
P
R
G
N
A
L
D
T
L
-
C
A
T
L
E
E
K
M
Q
F
E
E
G
E
R
D
L
V
-
M
L
-
Q
H
K
F
----
E
I
E
N
K
D
G
-
S
R
E
T
R
T
S
S
L
C
E
--------------------------------
6
PsiBlast_PDB
48.51
25%
-113
- C2 -
1E5L
-
LYS9_MAGO7
A:
[5-133]
---------
S
V
L
M
L
G
S
G
---
F
V
-
T
-
R
P
T
L
D
V
----------------------
L
T
D
S
-
G
I
K
V
T
-
V
A
C
R
T
L
---
E
S
A
K
K
------
L
S
A
G
V
Q
-----------
H
S
T
P
I
----------------
S
L
D
V
N
D
D
-
A
A
L
D
A
E
V
A
K
H
D
--
L
V
I
S
L
-
I
P
-
Y
T
F
H
---
A
-----
T
----
V
I
-
K
S
A
I
R
Q
K
K
H
V
V
-
T
T
S
Y
-
V
S
P
A
M
-------------------
M
E
--
L
--------
D
Q
A
A
K
D
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
I
K
T
I
E
E
V
H
----
A
-------------------------
A
G
G
------------------
K
I
K
T
-------
F
L
S
Y
C
G
G
L
-----
P
---
A
P
--
E
S
S
D
--------
N
P
L
G
Y
K
F
S
W
S
S
R
G
V
L
L
A
L
R
N
A
-------------------
A
S
F
Y
K
D
G
-
K
V
----
T
----
N
V
A
--------
G
P
E
-
L
-----------
M
A
--
T
A
K
P
Y
F
I
Y
P
G
--
F
A
F
V
A
Y
P
N
R
D
S
T
---
P
---
Y
K
E
R
Y
-
Q
I
P
E
A
D
N
-
I
V
R
-
G
T
L
R
Y
Q
G
F
P
Q
F
I
K
V
L
V
D
I
G
F
L
S
----------------------------------------------------------
D
E
E
Q
P
F
L
K
E
----------------------------------------------------------
A
----
I
P
W
K
E
A
T
Q
K
I
V
K
A
S
S
------------------------------------------------------
A
S
E
Q
D
-
I
V
S
-
T
I
-
V
S
N
------
A
T
F
E
S
T
E
E
Q
K
R
I
V
A
G
L
K
W
L
G
I
F
S
D
K
K
I
T
P
R
G
N
A
L
D
T
L
-
C
A
T
L
E
E
K
M
Q
F
E
E
G
E
R
D
L
V
-
M
L
-
Q
H
K
F
----
E
I
E
N
K
D
G
-
S
R
E
T
R
T
S
S
L
C
E
--------------------------------
4
PsiBlast_PDB
46.88
25%
-110
- C2 -
1FF9
2
LYS9_MAGO7
A:
[5-133]
---------
S
V
L
M
L
G
S
G
---
F
V
-
T
-
R
P
T
L
D
V
----------------------
L
T
D
S
-
G
I
K
V
T
-
V
A
C
R
T
L
---
E
S
A
K
K
------
L
S
A
G
V
Q
-----------
H
S
T
P
I
----------------
S
L
D
V
N
D
D
-
A
A
L
D
A
E
V
A
K
H
D
--
L
V
I
S
L
-
I
P
---F
H
---
A
-----
T
----
V
I
-
K
S
A
I
R
Q
K
K
H
V
V
-
T
T
S
Y
-
V
S
P
A
M
-------------------
M
E
--
L
--------
D
Q
A
A
K
D
A
G
I
T
V
M
N
E
I
G
--
L
D
P
--
G
I
D
H
L
Y
A
I
K
T
I
E
E
V
H
----
A
-------------------------
A
G
G
------------------
K
I
K
T
-------
F
L
S
Y
C
G
G
L
-----
P
---
A
P
--
E
S
S
D
--------
N
P
L
G
Y
K
F
S
W
S
S
R
G
V
L
L
A
L
R
N
A
-------------------
A
S
F
Y
K
D
G
-
K
V
----
T
----
N
V
A
--------
G
P
E
-
L
-----------
M
A
--
T
A
K
P
Y
F
I
Y
P
G
--
F
A
F
V
A
Y
P
N
R
D
S
T
---
P
---
Y
K
E
R
Y
-
Q
I
P
E
A
D
N
-
I
V
R
-
G
T
L
R
Y
Q
G
F
P
Q
F
I
K
V
L
V
D
I
G
F
L
S
----------------------------------------------------------
D
E
E
Q
P
F
L
K
E
----------------------------------------------------------
A
----
I
P
W
K
E
A
T
Q
K
I
V
K
A
S
S
------------------------------------------------------
A
S
E
Q
D
-
I
V
S
-
T
I
-
V
S
N
------
A
T
F
E
S
T
E
E
Q
K
R
I
V
A
G
L
K
W
L
G
I
F
S
D
K
K
I
T
P
R
G
N
A
L
D
T
L
-
C
A
T
L
E
E
K
M
Q
F
E
E
G
E
R
D
L
V
-
M
L
-
Q
H
K
F
----
E
I
E
N
K
D
G
-
S
R
E
T
R
T
S
S
L
C
E
--------------------------------
16
HHSearch
46.45
12%
-53
* C2 *
2PH5
2
?
A:
[13-429]
-------
K
N
R
F
V
I
L
G
F
G
C
V
G
Q
A
-
L
-
M
P
L
I
F
E
----------------------
K
F
D
I
K
P
S
Q
V
T
-
I
I
A
A
E
G
---
T
K
V
-
D
-
V
A
Q
Q
Y
G
----
V
-----------
S
F
K
L
Q
----------------
Q
I
T
P
Q
N
Y
L
E
V
I
G
S
T
L
E
--
E
N
D
F
L
I
D
V
S
I
G
-
I
S
-
S
---
L
-----
A
----
L
I
-
I
L
C
N
Q
K
G
A
L
Y
I
N
A
A
T
E
-
P
W
K
E
----------------------RR
T
N
Y
S
L
R
E
E
V
L
R
L
K
D
K
T
Q
K
T
A
L
I
T
H
G
--
A
N
P
--
G
L
V
S
H
F
I
K
E
A
L
L
-
N
I
----
A
-------------------------
K
D
N
G
L
T
I
N
RPKN
A
A
E
W
A
N
L
A
M
T
L
G
I
KVIHV
A
E
Q
D
S
Q
V
T
Y
P
-----
P
KSP
G
E
--
F
V
N
T
--------
W
S
A
N
G
L
I
L
E
G
L
Q
P
A
E
I
G
W
G
T
H
-------------------
E
A
H
W
P
H
D
-
A
Y
----
S
----
H
S
N
GPQC
A
I
Y
L
S
R
P
-
S
AG
V
M
V
R
S
W
T
PT
L
G
--
A
F
H
G
F
L
I
T
H
A
--
E
T
I
S
L
T
N
F
L
T
-
L
---
K
NGS
E
L
L
Y
R
P
T
V
H
Y
A
Y
N
P
C
P
D
A
R
L
S
I
F
E
L
K
S
N
E
W
---------------------------------------------------------------------
K
P
Q
N
K
N
R
L
----------------------------------------------------------
I
----
L
N
E
--
I
I
---
D
G
C
D
E
------------------------------------------------------
L
G
V
L
L
-
M
G
N
-
Q
R
-
G
A
Y
W
Y
G
S
T
L
S
I
Q
E
A
R
------
Q
I
A
P
Y
N
N
A
T
S
L
Q
V
V
A
S
-
M
I
S
G
I
I
W
A
----
I
E
H
P
D
----
E
G
I
V
E
P
-
E
E
-
V
D
H
Q
----
Y
I
I
D
I
A
K
-
P
Y
L
G
K
V
G
G
Y
Y
T
--------------------------------
24
HHSearch
46.17
16%
-94
- C2 -
3TNL
2
AROE_LISMO
A:
[155-295]
--------
K
K
M
T
I
C
G
A
G
G
A
A
T
A
-
I
-
C
I
Q
A
A
L
----------------------
D
G
-
V
--
K
E
I
S
-
I
F
N
R
K
D
DF
Y
A
N
A
E
K
-
T
V
E
K
I
N
S
K
--
T
-----------
D
C
K
A
Q
----------------
L
F
D
I
E
D
H
-
E
Q
L
R
K
E
I
A
--
E
S
V
I
F
T
N
A
T
G
V
-
G
M
-
K
---
P
FEGET
L
----
L
P
S
A
D
M
L
R
P
E
L
I
V
S
D
V
V
Y
K
-
P
T
K
-------------------------------
T
R
L
L
E
I
A
E
E
Q
G
C
Q
T
L
N
G
L
G
-----------
M
M
L
W
Q
G
A
K
A
F
E
----
I
-------------------------
W
T
H
------------------
K
E
M
P
-------
V
D
Y
I
K
E
I
L
-----
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
44.70
18%
-109
- C2 -
3MOI
-
?
A:
[2-150]
-------
K
I
R
F
G
I
C
G
L
G
F
A
G
S
V
L
M
-
A
P
A
M
R
H
----------------------
H
P
D
A
--
Q
I
V
A
-
A
C
D
P
N
E
---
D
V
R
E
R
-
F
G
K
E
Y
G
-----------------
I
P
V
-----------------------
F
-
A
T
L
A
E
M
M
Q
H
V
Q
M
D
A
V
Y
I
A
S
P
H
-
Q
F
-
H
---
C
-----
E
----
H
V
-
V
Q
A
S
E
Q
G
L
H
I
I
-
V
E
K
P
-
L
T
--------------------------
L
S
R
D
E
A
D
R
M
I
E
A
V
E
R
A
G
V
H
L
V
V
G
T
S
RS
H
D
P
--
V
V
R
T
L
R
A
I
V
Q
E
G
-
S
V
----
G
-------------------------
R
V
S
------------------
M
L
N
C
-------
F
N
Y
T
D
F
L
Y
-----
R
---
P
R
--
R
P
E
E
--------
L
D
T
S
K
G
G
G
I
I
Y
N
Q
L
P
H
Q
I
D
S
I
-------------------
K
T
I
T
G
Q
R
-
I
T
----
A
----
V
R
A
--------
M
T
G
-
R
-----------
L
D
--
P
K
R
P
T
E
G
N
C
A
--
A
M
L
T
L
E
D
G
A
C
A
V
---
M
---
V
Y
S
G
Y
-
D
H
F
D
S
D
E
-
M
H
F
-
W
L
A
E
G
G
R
A
K
Q
P
N
H
G
G
A
R
K
V
L
R
Q
----------------------------------------------------------
L
E
G
D
E
A
E
L
R
----------------------------------------------------------
R
----
S
R
Y
G
F
G
G
P
I
S
K
S
D
R
K
------------------------------------------------------
Q
P
H
F
G
-
V
M
L
-
V
T
-
C
E
H
------
A
D
L
R
A
S
P
E
G
V
L
V
Y
G
D
E
G
V
R
E
V
P
A
I
T
G
R
G
P
F
S
Q
G
D
T
I
D
-
E
L
R
D
A
I
A
G
V
A
P
A
L
R
D
A
R
W
-
G
K
-
D
T
L
E
----
V
C
L
A
V
L
E
-
S
S
A
T
G
R
Q
V
E
R
---------------------------------
25
HHSearch
44.57
23%
-86
- C2 -
3JYO
1
AROE_CORGL
A:
[128-251]
--------
D
S
V
V
Q
V
G
A
G
G
V
G
N
A
-
V
-
A
Y
A
L
V
T
----------------------
H
G
-
V
--
Q
K
L
Q
-
V
A
D
L
D
T
---
S
R
A
Q
A
-
L
A
D
V
I
N
N
---------------
A
V
G
R
E
----------------
A
V
V
G
V
D
A
-
R
G
I
E
D
V
I
A
--
A
A
D
G
V
V
N
A
T
P
M
-
G
M
-
P
---
A
-----
H
PGTA
F
D
-
V
S
C
L
T
K
D
H
W
V
G
D
V
V
Y
M
-
P
I
E
-------------------------------
T
E
L
L
K
A
A
R
A
L
G
C
E
T
L
D
G
T
R
--
M
A
I
--
H
Q
A
V
D
A
F
R
L
F
T
G
L
E
P
----
D
-------------------------
V
S
R
------------------
M
R
E
T
-------
F
L
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
43.34
12%
-99
- C2 -
3RC1
4
?
A:
[27-175]
-------
P
I
R
V
G
V
I
G
C
A
D
I
A
W
R
R
A
-
L
P
A
L
E
A
----------------------
E
P
L
T
--
E
V
T
A
-
I
A
S
R
R
W
---
D
R
A
K
R
-
F
T
E
R
F
G
-----------------
G
E
P
-----------------------
V
-
E
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
-
V
L
-
H
---
A
-----
E
----
W
I
-
D
R
A
L
R
A
G
K
H
V
L
-
A
E
K
P
-
L
T
--------------------------
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
G
L
L
L
M
E
N
F
M
FL
H
H
P
--
Q
H
R
Q
V
A
D
M
L
D
E
G
-
V
I
----
G
-------------------------
E
I
R
------------------
S
F
A
A
-------
S
F
T
I
P
P
K
P
-----
Q
---
G
D
--
I
R
Y
Q
--------
A
D
V
G
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
A
G
L
-------------------
F
L
G
A
D
L
E
-
F
V
----
G
----
A
V
L
--------
R
H
E
-
R
-----------
D
R
--
D
V
V
V
G
G
N
A
L
L
--
T
T
R
Q
G
V
T
A
Q
L
T
F
---
G
---
M
E
H
A
Y
-
T
N
N
Y
E
F
R
-
G
S
T
-
G
R
L
W
M
N
R
V
F
T
P
P
A
T
Y
Q
P
V
V
H
I
E
----------------------------------------------------------
R
Q
D
H
A
E
Q
F
V
----------------------------------------------------------
L
----
P
A
H
D
Q
F
A
K
S
I
R
A
F
A
Q
------------------------------------------------------
A
V
L
S
G
-
E
H
P
-
R
E
-
W
S
E
------
D
S
L
R
Q
A
S
L
V
D
A
V
R
T
G
A
R
D
I
Y
F
P
-------------------------------------------------------------------------------------------------
27
HHSearch
42.75
14%
-96
- C2 -
3DB2
-
?
A:
[5-152]
-------
P
V
G
V
A
A
I
G
L
G
R
W
A
Y
V
-
M
-
A
D
A
Y
T
K
----------------------
S
E
K
L
--
K
L
V
T
-
C
Y
S
R
T
E
---
D
K
R
E
K
-
F
G
K
R
Y
N
-----------------
C
A
---------------------
G
--
D
-
A
T
M
E
A
L
L
A
R
E
D
V
E
M
V
I
I
T
V
P
N
-
D
K
-
H
---
A
-----
E
----
V
I
-
E
Q
C
A
R
S
G
K
H
I
Y
-
V
E
K
P
-
I
S
--------------------------
V
S
L
D
H
A
Q
R
I
D
Q
V
I
K
E
T
G
V
K
F
L
C
G
H
S
SR
R
L
G
--
A
L
R
K
M
K
E
M
I
D
T
K
-
E
I
----
G
-------------------------
E
V
S
------------------
S
I
E
A
-------
V
F
S
N
E
R
G
L
-----
E
---
L
K
--
K
G
N
W
--------
R
G
E
P
A
T
A
P
G
G
P
L
T
Q
L
G
V
H
Q
I
D
-------------------
N
L
Q
F
L
L
G
-
P
V
----
A
----
R
V
F
--------
N
F
G
-
K
-----------
P
M
--
Y
T
E
V
E
N
I
T
V
N
--
Q
T
L
L
E
F
E
D
G
K
Q
A
---
Y
---
L
G
T
N
W
-
A
C
P
G
V
F
S
-
I
N
V
-
Y
G
T
K
A
N
L
F
Y
Q
L
D
F
S
W
W
S
N
S
D
V
T
----------------------------------------------------------
D
E
H
S
T
L
I
K
R
----------------------------------------------------------
E
----
F
A
S
N
R
I
L
R
D
V
K
V
D
F
E
------------------------------------------------------
S
V
D
H
L
-
R
V
E
-
V
E
-
E
V
A
------
D
V
I
R
N
G
G
E
T
E
I
G
A
E
A
S
L
R
N
L
A
V
V
L
A
A
V
K
S
V
H
E
K
R
P
V
E
-
I
A
E
I
I
G
---------------------------------------------------------------------------
23
HHSearch
42.04
14%
-72
- C2 -
1GR0
3
INO1_MYCTU
A:
[15-205]
-------
E
V
R
V
A
I
V
G
V
G
N
C
A
S
S
-
L
-
V
Q
G
V
E
Y
Y
Y
NADDT
S
T
V
P
GLMHVRFGPYH
V
R
D
V
--
K
F
V
A
-
A
F
D
V
D
A
---
K
K
V
G
F
D
L
S
D
A
I
F
A
S
-
E
N
NTIKI
A
D
V
A
PT
N
V
I
V
Q
R
G
PTLDGIG
K
Y
Y
A
D
T
I
E
L
S
D
A
E
P
-
V
D
V
V
Q
A
L
K
E
A
K
V
D
V
L
V
S
Y
L
P
V
-
G
S
-
E
E
A
D
K
-----
F
----
Y
A
-
Q
C
A
I
D
A
G
V
A
F
V
N
A
L
P
V
-
F
I
-----------------------------
A
S
D
P
V
W
A
K
K
F
T
D
A
R
V
P
-
I
V
G
D
D
--
I
K
S
QV
G
A
T
I
T
H
R
V
L
A
K
L
F
E
D
----
R
-------------------------
G
V
Q
------------------
L
D
R
T
-------
M
Q
L
N
V
G
G
N
-----
M
---
D
F
--
L
N
M
L
--------
E
D
V
H
I
G
P
S
D
H
V
G
W
L
D
D
R
K
W
A
Y
-------------------
V
R
L
E
G
R
A
-
F
G
----
D
----
V
P
L
--------
N
L
E
-
Y
-----------
K
L
--
E
V
W
D
S
P
N
S
A
G
--
V
I
I
D
A
V
R
A
A
K
I
A
---
K
---
D
R
G
I
G
-
G
P
V
I
P
A
S
-
A
Y
L
-
M
K
S
P
P
E
Q
L
P
D
D
I
A
R
A
Q
L
E
E
F
I
I
----------------------------------------------------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
40.95
15%
-86
- C2 -
3EUW
1
?
A:
[4-151]
-------
T
L
R
I
A
L
F
G
A
G
R
I
G
H
V
-
H
-
A
A
N
I
A
A
----------------------
N
P
D
---
L
E
L
V
V
I
A
D
P
F
I
---
E
G
A
Q
R
-
L
A
E
A
N
G
-----------------
A
E
---------------------
A
V
---
A
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
-
S
T
-
H
---
V
-----
D
----
L
I
-
T
R
A
V
E
R
G
I
P
A
L
-
C
E
K
P
-
I
D
--------------------------
L
D
I
E
M
V
R
A
C
K
E
K
I
G
D
G
A
S
K
V
M
L
G
F
N
RR
F
D
P
--
S
F
A
A
I
N
-
A
R
V
A
N
Q
E
I
----
G
-------------------------
N
L
E
------------------
Q
L
V
I
-------
I
S
R
D
P
A
P
A
-----
P
---
K
D
--
Y
I
A
G
--------
S
G
G
I
F
R
D
M
T
I
H
D
L
D
M
A
R
F
F
V
P
-------------------
N
I
V
E
V
T
A
-
T
G
----
A
----
N
V
F
--------
S
Q
E
-
I
-----------
A
E
--
F
N
D
Y
D
Q
V
I
V
T
--
L
R
G
S
K
G
E
L
I
N
I
V
---
N
---
S
R
H
C
S
-
Y
G
Y
D
Q
R
L
-
E
A
F
-
G
S
K
G
M
L
A
A
D
N
I
R
P
T
T
V
R
K
H
N
A
E
----------------------------------------------------------
S
T
E
Q
A
D
P
I
F
----------------------------------------------------------
N
----
F
F
L
E
R
Y
D
A
A
Y
K
A
E
L
A
------------------------------------------------------
T
F
A
Q
G
-
I
R
D
-
G
Q
-
G
F
S
------
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
S
A
Q
T
G
R
T
V
T
L
N
P
A
----------------------------------------------------------------------------------------
18
HHSearch
40.79
13%
-56
- C2 -
3WB9
5
?
A:
[9-292]
-------
K
L
R
V
A
V
V
G
Y
G
N
V
G
R
Y
-
A
-
L
E
A
V
Q
A
----------------------
A
P
D
---
M
E
L
V
-
G
V
V
R
R
K
---
V
L
A
A
--
T
P
P
---------------------
E
L
T
----------------
G
V
R
V
V
T
---
D
I
S
Q
L
E
G
---
V
Q
G
A
L
L
C
V
P
T
-
R
S
-
V
---
P
-----
E
----
Y
A
-
E
A
M
L
R
R
G
I
H
T
V
D
S
Y
D
I
-
H
G
--------------------------
D
L
A
D
L
R
R
R
L
D
P
V
A
R
E
H
G
A
A
A
V
I
S
A
G
--
W
D
P
--
G
T
D
S
I
I
R
A
-
L
L
E
F
M
A
----
P
-------------------------
K
G
I
------------------
T
Y
T
N
-------
F
G
P
G
M
S
M
----------------------------------
G
H
S
--
V
A
V
K
A
I
P
G
-------------------
V
R
-------
D
----
A
----
L
S
M
--------
T
I
P
A
G
-----------
M
G
V
H
K
R
A
V
Y
V
E
L
E
P
GA
D
F
A
E
V
E
R
A
I
K
---------
T
D
P
Y
F
-
V
R
D
E
T
-
R
-----
V
T
Q
V
E
----------------------------------------------------------------------------
S
-----
V
----------------------------------------------------------------
S
A
L
---
M
---
D
V
G
H
G
------------------------------------------------------
V
V
M
E
R
-
K
G
V
-
S
G
A
T
H
N
------
Q
L
F
R
F
E
---
M
--------
R
I
N
-
N
P
A
L
T
A
Q
V
M
V
A
A
L
R
A
-
A
A
R
---
Q
K
----
P
G
C
Y
T
M
I
E
I
-
P
V
I
D
----
Y
L
P
G
D
R
E
-
A
W
I
R
K
L
V
------------------------------------