@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0008: (2016-03-11 )
MRKLIQFLFIAVVLFLVEYVLINQAAILFLVTSGIIQLCGVIIAIRLLLFDQRNTSSKVAWVAVIFILPVLGTISYLVFGRNPATRKFSTAQVKEKTKLINAIHAIPNNTNEKLPRLSKRIAHLTSIEPIKGNKIEILTNGEETFPVLLDALRKAENHIHIQYYIFKTDAISTEIRDILVEKAKSGVEVRFMFDGLGSSKLGKAFLAPLKEAGVSIHAFDPIASPWIVRTANLRNHRKIVVIDGQIGFTGGLNIGEEYRSNTPDFRVWRDTHIKITGQAVIELQESFLNDWVYMENQAGAADGFISESGSKQYFSPVDMGDEWAQVIYGGPYDKEKWVRDSMLDLIDSAKESVWIVSPYFVPDEESLAVIRRVAMSGVDVRVIIPGKGDRGISFHGSNAYVKTMIEAGAKMYAYADDSFVHAKAMLVDGTRAAIGTANFDVRSFRLNHELMVFLYDESEAMHHLKRDFKKDFEDSRLFTMKDMENKPLLTRIKEVLSSLLSPIL
Atome Classification :
(20 SA)
-----------------------------------------------------------........---.-----------10.-----..---.....20........30........-----------------------------40.....---...50.......--.-------60-------------.....--------....70........-80.-----.....-..90......-..100--...-....110---........120.......-.130--........140....---....150...-------..-----..---------------160...--------.-...----.170.-......180--....--..----.190-.---------------------------.-.---....200-.........210-----.....--.----..220--..-.------.....230........240---..--.-------....250-..-.-------....260.......270--..--...---.-.-.-----280.......-------------290----------------....---....-300--..---.----------.-.-.--.---.310-.--------.....-----------.--..320---...-----------------.-----..----.---------------.-------------------------------------330-----.----...-------...-------340-----.....--....350--.-----.....--------...-360----.-.--------.--.----------.....370...-..--.--.380.......390---------...----..------.----------.400-----.....------------------------.------.--.---.410--------------------------------------------....----------.------------..------------------------------.----------------------------420--.-...-----..----.-..430-----......-------...-------------440...----.....450..--------.-------.-..-.460----....-...----470.---....----.----.480-.--------------....-...-.490.--.....-------.500...-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------
M
R
K
L
I
Q
F
L
---
F
-----------
I
A
V
-----
V
L
---
F
L
V
E
Y
V
L
I
N
Q
A
A
I
L
F
L
V
T
S
G
I
I
Q
L
C
-----------------------------
G
V
I
I
A
I
R
---
L
L
L
FDQRNTSS
K
--
V
-------
A
--------------
W
V
A
V
I
--------
F
I
L
P
V
L
G
T
I
S
Y
L
VF-GRN-----PATRK-F
S
T
A
Q
V
K
E
K
T
-
K
L
I
N
A
--
I
H
A-IPNNTN----
E
K
L
P
R
L
S
K
R
I
-
A
H
L
TSIE-PIK---G
N
K
I
E
I
L
TN-GE
E
T
F
---
P
V
L
L
D
A
L
R
KA-------EN-----
H
I
---------------
H
I
-
Q
Y
Y
--------
I
-
F
KT----DA
I
S
T
-
E
I
R
D
I
L
V
E
K
--AKSG--
V
E
----
V
R
F
M
-F---------------------------D-G---LGS
S
K
---
L
G
K
A
F
L
A
P
L
K
E------AG
V
S
I
--
H
----AFDP---IA-S------
P
W
I
V
R
T
A-NLRN
H
R
K
I
V
V
I
---DG--Q-------IGFTGGL-NI-
G
-------
E
E
YRSNTP
D
F
R
V
W
R
D
T
---
H
I
--
K
I
T---
G
-
Q
-
A
-----
V
I
E
L
Q
E
S
F
L
N-------------D
W
-----------------
V
Y
ME---NQAG-AA---DG---F----------I-S-E--S---GS---K--------QYFSP-----------V--DM
G
D
----
E
W
A
-----------------
Q
-----
V
I
----Y---------------G-------------------------------------GPY-----
D
----
K
E
K
-------
W
V
R
-------
D
-------
S
M
L
D
L
--
I
D
SAK----E-----
S
V
W
I
V--------SPY-F------V-P--------D--
E
----------
E
S
L
A
V
I
R
R
V
A
M-SG--V--
D
V
R
V
I
IPGKGDR
G
I
---------
S
FH----GS------
N
----------
A
Y
-------
V
K
T
M
I
------------------------E------A--G---A
K
M
---------------------------------------------
Y
A
YA----------D------------DS------------------------------
F
----------------------------
V
----
H
-
A
K
A
-----
M
L
----V-DGT-------R
A
A
IGT-------AN
F
-------------
D
V
-
R
S
F
----
R
LN
H
E
L
M
V
F
L
--------Y-------D-
E
S
-
E
A
M
H
----
H
L
K
R
-
D
F
K
----
K
DFE---DS
R
L
----
F
----
T
M---K--------------DMEN-K
P
L
-
L
T
R
I
K
--
E
V
L
S
S
-------
L
L
-
S
PIL-------------------------------
39
Fugue
87.55
18%
-55
- C4 -
1F0I
2
?
A:
[1-504]
------------------------------------------------------------
A
A
T
P
H
L
D
---
A
-----------
V
E
Q
-----
T
L
---
R
Q
V
S
P
G
L
E
G
D
---
V
W
E
R
T
S
G
---------------------------------------------------
N
K
L
D
G
--
S
-------
A
--------------
A
D
P
S
D
--------
W
L
L
Q
T
P
G
C
-----
W
-
G
D
D
-----
K
C
A
D
R
-
V
G
T
K
R
L
L
A
K
M
-
T
E
N
I
G
---------------------
N
A
T
R
T
-
V
D
I
S
T
L
A
-
P
-----------
F
P
N
-
G
-
A
F
Q
---
D
A
I
V
A
G
L
K
E
S
-------
A
A
-----
K
G
---------------
N
-------------------------
S
L
-
K
V
R
I
L
V
G
A
A
--
P
H
M
N
--
G
I
----
P
S
K
Y
-
R
---------------------------
D
-
K
---
L
-
T
A
K
---
L
G
------
K
A
A
------
E
N
I
T
L
--
N
----
V
A
S
M
---
T
T
-
S
----------
K
T
A
-
F
S
W
N
H
S
K
I
L
V
V
---
D
G
--
Q
-------
S
A
L
T
G
G
I
-
N
S
W
K
-------
D
D
Y
L
D
T
T
H
P
V
S
---
D
V
---
D
L
--
A
L
T
---
G
-
P
-
A
-----
A
G
S
A
G
R
Y
L
D
T
-------------
L
W
-----------------
T
W
T
C
---
K
N
K
S
-
N
I
---
A
S
---
V
----------
W
-
F
-
A
--
A
---
S
G
---
N
--------
A
G
C
M
P
TMHKDTNPKAS
P
--
A
T
G
N
----
V
P
V
-----------------
I
-----
A
V
----
G
---------------
G
LGVGIKDVDPKST
F
R
P
D
L
P
T
ASDTKCVVGLHDNTNAD
R
D
Y
-----
D
----
T
V
N
-------
P
E
E
-------
S
-------
A
L
R
A
L
--
V
A
S
A
K
----
G
-----
H
I
E
I
S
Q
QDLNATC
P
P
L
-
P
------
R
-
Y
--------
D
--
I
----------
R
L
Y
D
A
L
A
A
K
M
A
-
A
G
--
V
--
K
V
R
I
V
V
S
D
P
A
N
R
G
Y
---------
S
Q
I
----
K
S
------
L
----------
S
E
-------
I
S
D
T
L
------------------------
R
------
N
--
R
---
L
A
N
---------------------------------------------
I
T
G
G
----------
Q
------------
Q
A
------------------------------
A
K
T
A
M
C
S
N
L
Q
L
A
T
F
R
SSPNGKWADGH
P
Y
A
Q
----
H
-
H
K
L
-----
V
S
----
V
-
D
S
S
-------
T
F
Y
I
G
S
-------
K
N
L
-------------
Y
P
-
S
-------
W
L
Q
D
F
G
Y
I
V
--------
E
-------
S
-
P
E
-
A
A
K
Q
----
L
D
A
K
-
L
L
D
----
P
Q
W
K
---
Y
S
Q
E
----
T
----
A
T
---
V
--------------
D
Y
A
R
-
G
I
C
-
G
A
-------------------------------------------------------
37
Fugue
83.24
17%
-43
- C4 -
3HSI
-
PSS_HAEIN
A:
[4-454]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
T
K
R
A
E
Q
N
L
-
N
N
L
P
F
L
A
--
L
Q
---
A
E
Q
I
E
F
L
G
S
-
S
A
E
F
K
---
T
Q
I
I
E
L
I
R
N
A
-------
K
K
-----
R
I
---------------
Y
V
-
T
A
L
--------
Y
-
W
Q
K
----
D
E
A
G
Q
-
E
I
L
D
E
I
Y
R
V
--
K
Q
E
N
PH
L
D
----
V
K
V
L
-
I
---------------------------
D
W
H
---
R
A
Q
R
N
---
L
L
A
T
N
A
D
W
Y
C
E
------
Q
R
Q
T
Y
--
Q
----
L
P
D
D
PNF
F
G
-
V
------
P
I
N
T
R
E
V
-
F
G
V
L
H
V
K
G
F
V
F
---
D
D
--
T
-------
V
L
Y
S
G
A
--
S
I
-
N
-------
N
V
Y
L
H
Q
F
E
K
Y
R
Y
D
R
Y
Q
---
K
I
T
H
A
E
L
---
A
-
D
-
S
M
----
V
N
F
I
N
D
Y
L
L
D
FSAVYPLDVTNRP
R
T
-----------------
K
E
I
R
---
G
N
I
R
-
A
Y
---
R
K
---
D
----------
L
-
A
-
Q
--
N
---
G
E
---
Y
--------
S
L
K
S
A
-----------
V
--
K
L
P
N
----
V
L
S
-----------------
V
-----
S
P
----
L
---------------
F
-------------------------------------
G
L
G
-----
A
----
S
G
N
-------
E
L
N
-------
Q
-------
V
I
E
D
L
--
F
L
Q
V
Q
----
K
-----
K
L
V
I
C
--------
T
P
Y
-
F
------
N
-
F
--------
P
--
R
----------
T
L
Q
H
K
I
A
T
L
L
E
-
N
G
--
K
--
R
V
E
I
I
V
G
D
K
V
A
N
D
F
---------
Y
I
P
----
P
E
------
Q
PFKMAGAL
P
Y
L
Y
-------
E
S
N
L
R
------------------------
R
------
F
--
C
---
E
K
F
---------------------------------------------
E
T
Q
I
----------
E
S
G
QL
V
V
R
L
W
R
D
G
D
N
------------------------------
T
----------------------------
Y
----
H
-
L
K
G
-----
V
W
----
V
-
D
D
R
-------
Y
I
L
L
T
G
-------
N
N
L
-------------
N
P
-
R
A
W
----
R
L
D
A
E
N
G
L
L
I
--------
Y
-------
D
-
P
Q
-
Q
Q
L
L
----
A
Q
V
E
-
K
E
Q
----
N
Q
I
R
---
Q
-
H
T
----
K
----
V
L
---
K
--------------
H
Y
T
E
-
L
E
E
-
L
N
Q
Y
P
--
E
P
V
Q
K
-------
L
L
-
K
K
F
A
R
I
K
A
D
K
L
V
K
M
I
L-------------------
18
HHSearch
82.80
18%
-73
- C4 -
1V0W
1
?
A:
[61-500]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
-
T
K
R
L
L
---
A
K
M
T
E
N
I
G
N
A
-------
T
R
-----
T
V
---------------
D
I
-
S
T
L
--------
A
P
F
P
N
----
G
A
F
Q
D
-
A
I
V
A
G
L
K
E
S
--
A
A
K
G
N
K
L
K
----
V
R
I
L
-
V
---------------------------
G
-
A
---
A
P
--
H
MNV
I
P
S
K
Y
R
D
E
L
T
A
K
L
G
K
A
A
E
N
I
T
L
--
N
----
V
A
S
M
---
T
-----------
T
S
K
T
A
-
F
S
W
N
H
S
K
I
L
V
V
---
D
G
--
Q
-------
S
A
L
T
G
G
I
-
N
S
-
W
K------
D
D
Y
L
D
T
---
T
H
P
V
S
D
V
---
D
L
--
A
L
T
---
G
-
P
-
A
-----
A
G
S
A
G
R
Y
L
D
T
-------------
L
W
-----------------
T
W
T
C
---
Q
N
K
S
-
N
I
---
A
S
---
V
----------
W
F
A
A
S
GN
A
---
G
C
---
M
PTMHKDTN
P
K
A
-
S
-----------
P
--
A
T
G
N
----
V
P
V
I
A
V
G
G
LGVGIKDVDPKS
T
-----
F
R
----
P
D
L
P
T
A
SDTKCVVGLH
D
-------------------------------------
N
T
N
AD
R
D
Y
D
----
T
V
N
-------
P
E
E
-------
S
-------
A
L
R
A
L
--
V
A
S
A
K
----
G
-----
H
I
E
I
S
--------
Q
Q
D
-
L
------
N
-
A
TCPPLPRY
D
--
I
----------
R
L
Y
D
A
L
A
A
K
M
A
-
A
G
--
V
--
K
V
R
I
V
V
S
D
P
A
N
R
-------------------
G
------
Y
----------
S
Q
-------
I
K
S
L
S
E
I
S
D
T
L
R
N
R
L
A
N
I
T
GG
Q
Q
A
A
K
T
A
M
C
------
S
--
N
---
L
Q
L
---------------------------------------------
A
T
F
R
SSPNGKWADG
H
------------
P
Y
------------------------------
A
----------------------------
Q
----
H
-
H
K
L
-----
V
S
----
V
-
D
S
S
-------
T
F
Y
I
G
S
-------
K
N
L
-------------
Y
P
-
S
W
L
-------
Q
D
F
G
Y
I
V
--------
E
-------
S
-
P
E
--
A
A
K
----
Q
L
D
A
K
L
L
D
----
P
Q
W
K
---
Y
S
Q
E
----
T
----
A
T
---
V
--------------
D
Y
A
---------------------------------------------------------------
17
HHSearch
77.90
15%
-26
* C4 *
3HSI
-
PSS_HAEIN
A:
[13-446]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
L
P
F
L
-
A
L
Q
---
A
E
Q
I
E
F
L
G
S
-
S
A
E
F
K
---
T
Q
I
I
E
L
I
R
N
A
-------
K
K
-----
R
I
---------------
Y
V
-
T
A
L
--------
Y
-
W
Q
K
----
D
E
A
G
Q
-
E
I
L
D
E
I
Y
R
V
K
Q
E
N
P
H
--
L
D
----
V
K
V
L
-
I
---------------------------
D
-
W
---
H
R
A
Q
R
---
N
L
L
-----
A
T
N
------
A
D
W
Y
C
E
Q
R
----
Q
T
Y
Q
---
L
P
D
D
PNF
F
G
V
P
I
N
T
R
E
V
-
F
G
V
L
H
V
K
G
F
V
F
---
D
D
--
T
-------
V
L
Y
S
G
A
--
S
I
-
N
-------
N
V
Y
L
H
Q
F
--
E
K
Y
R
Y
D
R
---
Y
Q
--
K
I
T
---
H
-
A
E
L
-----
A
D
S
M
V
N
F
I
N
D
-------------
Y
L
-----------------
L
D
F
S
---
A
V
Y
P
L
D
V
TNR
P
R
TKE
I
----------
R
-
G
N
I
--
R
---
A
Y
R
K
D
L
--------
A
Q
N
G
E
-----------
Y
S
L
K
S
A
V
----
K
L
P
-----------------
N
-----
V
L
----
S
---------------
V
-------------------------------------
S
P
L
-----
F
G
L
G
A
S
G
N
-------
E
L
N
-------
Q
-------
V
I
E
D
L
--
F
L
Q
V
Q
----
K
-----
K
L
V
I
C
--------
T
P
Y
-
F
------
N
-
F
--------
P
--
R
----------
T
L
Q
H
K
I
A
T
L
L
E
-
N
G
--
K
--
R
V
E
I
I
V
G
D
K
V
A
N
D
F
YIPPEQPFK
M
A
G
AL
P
Y
L
Y
------
E
----------
S
N
L
R
R
F
C
E
K
F
E
T
Q
I
------------------------
E
------
S
--
G
QL
V
V
R
L
---------------------------------------------
W
R
D
G
-----------------------
D
N
------------------------------
T
----------------------------
Y
----
H
-
L
K
G
-----
V
W
----
V
-
D
D
R
-------
Y
I
L
L
T
G
-------
N
N
L
-------------
N
P
-
R
A
W
----
R
L
D
A
E
N
G
L
L
I
--------
Y
-------
D
-
P
Q
Q
Q
L
L
A
----
Q
V
E
K
-
E
Q
N
----
Q
I
R
Q
---
H
T
K
V
----
L
KHYT
E
L
---
E
--------------
E
L
N
Q
Y
P
E
P
-
V
Q
K
L
L
--
K
K
F
A
R
-------
I
K
------------------------------------
43
Fugue
75.61
19%
-62
- C5 -
2I3O
-
?
D:
[2-516]
-----------------------------------------------------------
F
R
S
R
P
N
A
L
---
S
-----------
Q
R
S
-----
V
I
---
A
S
S
S
-
E
L
A
S
L
A
G
R
D
I
L
K
R
G
G
--
N
I
F
-----------------------------
D
A
A
L
A
V
S
---
A
L
C
V
T
Q
N
N
L
C
G
---
L
-------
G
--------------
G
D
L
F
A
--------
L
I
R
D
E
N
G
Q
I
D
--
L
N
-
G
S
G
-----
Q
A
S
R
A
-
V
S
I
D
Y
Y
E
S
G
L
-
T
K
I
P
E
--
R
G
P
-
Y
A
A
I
T
V
PGIA
G
S
W
D
E
I
F
R
K
F
-
A
--
T
D
I
A
-
D
I
L
---
E
P
A
I
R
T
A
S
A
-
G
F
P
I
T
---
Q
N
Y
S
D
S
I
A
R
S
-------
A
P
-----
V
I
GQY------------
R
G
-
W
S
S
--------
I
-
F
P
N
----
G
S
V
P
V
-
A
G
E
I
L
K
Q
P
D
--
L
A
E
S
--
F
R
----
L
S
E
E
G
F
---------------------------
R
-
S
---
F
Y
D
G
S
---
L
A
D
I
I
I
A
G
L
E
G
------
T
G
--------------------
S
------
P
L
--
S
D
R
-
D
L
R
V
Y
R
--------------------------
P
-
L
I
-
G
-------
K
P
V
F
T
D
L
D
E
F
R
I
Y
E
T
S
---
P
---
N
S
Q
---
G
-
I
-
T
-----
V
I
E
W
I
R
G
E
S
H
-------------
G
Y
-----------------
D
S
R
T
---
W
E
A
K
-
I
E
---
D
I
---
F
----------
E
-
T
-
E
--
E
---
A
Y
---
D
--------
K
R
R
K
I
-----------
T
--
D
P
S
Y
----
N
I
A
-----------------
Q
-----------
H
---------------
D
-------------------------------------
S
A
N
-----
G
----
K
G
L
-------
P
K
R
-------
D
HNDIGDT
T
Y
F
S
I
--
S
D
S
E
G
----
R
-----
S
V
S
I
I
--------
Q
S
N
-
Y
GFGSGI
V
-
P
--------
K
--
G
----------
T
G
F
V
L
Q
N
R
G
S
Y
-
F
T
--
L
QR
D
H
P
N
A
L
P
G
K
R
-------------
T
F
H
----
T
L
------
A
----------
A
C
-------
V
E
K
E
H
------------------------
D
------
L
--
Y
---
A
S
L
---------------------------------------------
G
S
G
G
----------
D
-------------------------------------------------------------------------
I
----
Q
-
P
Q
V
QQILE
I
L
----
K
-
D
N
T
-------
D
---
P
Q
-------
A
I
L
-------------
D
K
-
P
R
W
----
T
E
P
Y
T
I
------------
Y
-------
E
-
A
P
-
G
A
V
Y
VESE
E
L
Y
R
-
N
V
S
----
K
Q
I
S
---
G
R
K
V
----
V
----
L
R
DVS
Q
--------------
E
F
G
T
-
A
Q
I
-
T
T
L
I
R
GD
V
V
V
G
A
ADPRGDG
I
A
-
I
P
Y
S
-------------------------------
46
Fugue
70.30
21%
-48
- C3 -
4UNM
4
?
A:
[8-615]
--------------------------------------------------------K
Y
H
Q
Y
K
I
N
Q
P
E
---
Y
-----------
K
A
A
N
G
K
W
E
I
I
---
E
F
P
E
K
Y
R
Q
N
T
I
H
A
A
L
L
R
T
G
K
V
L
M
V
A
-----------------------------
G
S
-----------
G
N
N
Q
D
N
S
D
D
--
K
-------
Q
--------------
Y
D
T
R
I
--------
W
-
D
P
V
K
G
T
I
K
K
V
P
T
-
P
S
D
-----
L
-----
F
C
T
G
H
T
Q
L
A
N
G
N
L
L
I
A
G
G
T
K
R
-
Y
E
K
L
K
G
----
D
V
T
K
A
G
G
L
M
V
-
V
H
N
E
N
P
D
K
P
I
T
L
P
A
G
T
K
F
T
G
K
E
N
-
G
K
T
F
V
S
K
D
P
V
L
V
P
R
A
E
K
V
-------
R
N
-----
D
P
---------------
G
L
-
G
R
I
--------
Y
-
V
E
A
QKSG
S
A
Y
E
T
-
G
T
E
D
N
Y
R
V
Q
--
G
L
S
G
--
A
D
----
A
R
N
T
-
Y
---------------------------
G
-
I
---
A
Q
K
L
A
---
L
D
K
K
D
F
Q
G
I
R
D
----------
A
--
F
----
E
F
D
P
---
V
A
-
E
------
K
Y
I
K
V
D
P
-
M
H
E
A
R
W
Y
P
T
L
T
T
L
G
D
G
--
K
-------
I
L
S
V
S
G
L
D
D
I
-
G
QLVPGK
N
E
V
Y
D
P
K
T
K
A
W
T
Y
T
D
K
V
---
R
Q
--
F
P
T
---
Y
-
P
-
A
-----
L
F
L
M
Q
----
N
-------------
G
K
-----------------
I
F
Y
------
S
G
-
A
N
---
A
G
---
Y
GPDDVGR
T
P
G
V
-
W
-
D
--
V
---
E
T
---
N
--------
K
F
T
K
V
-----------
P
--
G
M
S
D
ANML
E
T
A
-----------------
N
-----
T
V
----
L
---------------
L
-------------------------------------
P
P
A
-----
Q
----
D
E
K
-------
Y
M
V
I
G
GGGVG
E
-------
S
K
L
S
S
--
E
K
T
R
I
----
A
-----
D
L
K
A
D
--------
D
P
K
-
F
------
V
-
D
--------
G
--
P
-----------
S
L
E
K
G
T
R
Y
P
Q
-
A
S
--
I
L
P
D
D
S
V
L
V
S
G
G
S
Q
D
Y
R
---------
G
R
G
----
D
S
------
N
----------
I
L
-------
Q
A
R
L
Y
------------------------
H
------
P
--
D
---
T
N
E
---------------------------------------------
F
E
R
V
----------
A
------------
D
P
------------------------------
L
----------------------------
V
G
R
N
Y
H
-
S
G
S
-----
I
L
----
L
P
D
G
R
-------
L
M
F
F
G
S
D
S
LYADK
A
N
T
-------------
K
P
-
G
K
F
----
E
Q
R
I
E
I
Y
T
P
P
--------
Y
L
Y
R
DS
R
P
D
-
L
S
-
G
G
P
Q
----
T
I
A
R
-
G
G
S
----
G
T
F
T
---
S
R
A
A
----
S
----
T
V
---
K
KVRLIRPSASTHVT
D
V
D
Q
-
R
S
I
-
A
L
D
F
K
--
A
D
G
D
K
-------
L
T
-
V
T
V
P
SGKNLVQS
G
W
Y
M
M
F
V
T
D
GEGTPSK
A
E
W
V
R
V
P
40
Fugue
68.98
16%
-65
* C5 *
2ECF
-
?
A:
[22-741]
-----KLT
L
E
A
I
T
GPLPLS
G
P
T
L
M
K
P
K
V
A
PDGS
R
V
T
F
L
R
G
K
DSDRN
Q
L
D
L
W
S
Y
D
IGSGQ
T
R
L
L
V
D
S
K
---
V
-----------
V
L
A
-----
M
T
---
G
I
V
D
Y
Q
W
S
P
D
A
Q
R
L
L
F
P
L
G
G
E
L
Y
L
Y
D
LKQEGKAAVRQLTHGEGFATD
A
K
L
S
PKG
G
F
V
S
F
I
R
GR
N
L
W
V
I
D
L
A
S
G
R
Q
M
--
Q
-------
L
TADGSTTIGNGIAE
F
V
A
D
E
EMDRHTG
Y
W
W
A
P
D
D
S
A
I
A
Y
A
R
I
-
D
E
S
-----
P
V
P
V
Q
-
K
R
Y
E
V
Y
A
D
R
T
-
D
V
I
E
Q
--
R
Y
P
-
A
A
G
D
A
N
----
V
--------
Q
-
V
K
L
G
V
I
S
-
P
A
E
---
Q
A
Q
T
Q
W
I
D
L
-
G
K
E
Q
D
---
I
Y
L
A
R
V
N
W
R
D
-------
P
Q
-----
H
L
---------------
S
F
-
Q
R
Q
S
RDQK
K
L
D
L
-
V
E
V
----
T
L
A
S
N
-
Q
Q
R
V
L
A
H
E
T
--
S
P
T
W
--
V
P
L
H
NS
L
R
F
L
-
D
---------------------------
D
-
G
S
I
L
W
S
S
E
R
---
T
G
F
Q
H
L
Y
R
I
D
S
------
K
G
K
A
A
--
A
----
L
------
T
H
-
G
------
N
W
S
V
D
E
L
L
A
V
D
E
K
A
G
L
A
Y
F
---
R
A
--
G
-------
I
E
S
A
R
E
S
-
Q
I
-
Y
-------
A
V
P
L
Q
G
G
Q
P
Q
R
L
S
K
A
P
G
M
H
S
A
--
S
F
A
RNA
S
-
V
-
Y
-----
V
D
S
W
S
N
N
S
T
P
-------------
P
Q
-----------------
I
E
L
F
---
R
A
N
G
-
E
K
---
I
A
---
T
----------
L
-
V
-
E
--
N
D
LA
D
P
---
K
--------
H
P
Y
A
R
-----------
Y
--
R
E
A
Q
----
R
P
V
-----------------
E
-----
F
G
----
T
---------------
L
-------------------------------------
T
A
A
-----
D
----
G
K
T
-------
P
L
N
-------
Y
-------
S
V
I
K
P
AG
F
D
P
A
K
----
R
-----
Y
P
V
A
V
--------
Y
V
Y
-
G
------
G
-
P
--------
A
--
S
QTVTDSWPGR
G
D
H
L
F
N
Q
Y
L
A
Q
-
Q
G
Y
-
V
--
V
F
S
L
D
N
R
G
T
P
R
R
G
R
---------
D
F
G
----
G
A
LYGKQG
T
----------
V
E
-------
V
A
D
Q
L
------------------------
R
------
G
--
V
---
A
W
L
K
Q
QPWVDPA
R
I
G
V
Q
G
W
S
N
G
G
Y
M
T
L
M
L
L
A
K
ASDSYA
C
G
V
A
G
APVTD
W
G
L
Y
----------
D
------------
S
H
------------------------------
Y
----------------------------
T
----
E
-
R
Y
M
-----
D
L
----
P
-
A
R
N
-------
D
A
G
Y
R
E
-------
A
R
V
-------------
L
T
-
H
I
E
----
G
L
R
S
P
L
L
L
I
H
G
MADDNVL
F
-------
T
-
N
S
-
T
S
L
M
----
S
A
L
Q
-
K
R
G
----
Q
P
F
E
---
L
M
T
Y
P
GAK
H
----
G
L
---
S
--------------
G
A
D
A
-
L
H
R
-
Y
R
V
A
E
--
A
F
L
G
R
-------
C
L
-
K
P
---------------------------------
19
HHSearch
64.48
18%
-72
- C4 -
1XDP
3
PPK_ECOLI
A:
[340-657]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
Y
Y
-
P
Y
H
T
F
---
E
H
V
L
E
L
L
R
Q
A
-------
S
F
DPSVL
A
I
---------------
K
I
-
N
I
Y
--------
R
-
V
A
K
----
D
---
S
-
R
I
I
D
S
M
I
H
A
--
A
H
N
G
--
K
K
----
V
T
V
V
-
V
---------------------------
E
-
L
---
Q
A
R
F
D
E
E
-
A
N
I
H
W
A
K
R
L
T
E
------
A
G
V
H
V
--
I
----
F
S
A
P
---
G
------------------
L
K
I
H
A
K
L
F
L
I
---
S
R
--
K
E
NG
E
V
V
R
Y
A
H
I
G
T
G
-
N
F
-
N
-------
E
K
T
A
R
------
L
Y
T
D
Y
---
S
L
--
L
T
A
---
D
-
A
R
I
-----
T
N
E
V
R
R
V
F
N
F
-------------
I
E
-----------------
N
P
Y
R
---
P
V
---
T
F
---
D
---------------------------------------------------------------------------------------
Y
-----
L
M
----
V
-----------------------------------------------------
S
P
Q
-----
N
----
S
R
R
-------
L
L
Y
-------
E
-------
M
V
D
R
E
--
I
A
N
A
Q
Q
G
L
P
S
-----
G
I
T
L
K
--------
L
N
N
-
L
------
V
----------
D
--
K
----------
G
L
V
D
R
L
Y
A
A
S
S
-
S
G
--
V
--
P
V
N
L
L
V
R
G
M
C
S
L
I
----------------------------------------------
P
N
L
E
------------------------
G
------
I
SD
N
---
I
R
A
---------------------------------------------
I
S
I
V
----------
D
------------
R
Y
------------------------------
L
----------------------------
E
----
H
-
D
R
V
-----
Y
I
----
F
-
E
N
G
GD
K
----
K
V
Y
L
S
S
-------
A
D
W
-------------
M
T
-
R
N
I
----
D
Y
R
I
E
V
A
T
P
L
--------
L
-------
D
-
P
R
--
L
K
Q
----
R
V
L
D
-
I
I
D
----
I
L
F
S
DTV
K
A
R
Y
----
I
----
D
K
---
E
--------------
L
-----------------------------------------------------------------
42
Fugue
64.24
19%
-52
- C1 -
4OO3
-
?
A:
[3-441]
---------------------------------------------------EGFTGAPG
E
V
K
L
I
T
L
D
PGH
F
-----------
H
A
A
-----
L
V
---
Q
K
V
S
Y
P
Q
V
S
K
D
V
Y
V
Y
A
P
T
------------------------------------
G
F
D
V
D
E
H
---
L
K
R
I
Q
G
F
N
T
R
A
E
N
P
T
-------
A
--------------
W
N
E
I
V
--------
Y
T
G
D
-----
D
Y
L
E
K
M
L
A
E
-----
K
K
G
N
V
M
I
Q
A
G
N
N
G
K
K
T
-
E
Y
I
K
K
--
T
L
E
-
A
G
I
N
V
----------
L
S
D
K
P
M
A
I
----------------------
N
S
Q
S
F
---
K
L
L
E
E
C
F
A
I
A
-------
K
Q
-----
K
----------------
N
I
M
L
Y
D
--------
I
M
T
E
R
----
N
E
I
T
T
M
L
Q
R
E
L
S
T
I
P
--
A
V
Y
G
--
E
Q
----
L
K
--------------------------------------
G
S
P
E
------------------------------------------
E
------
P
A
I
V
K
E
S
-
V
H
H
L
F
K
L
V
-----------------------------------------
D
N
K
P
L
T
R
P
V
W
Y
L
---
D
V
--
N
Q
Q
---
G
-
E
-
G
-----
I
V
D
V
-
T
T
H
L
V
-------------
D
L
-----------------
V
Q
W
E
AFP
D
Q
I
I
-
D
Y
---
R
K
---
D
----------
I
-
E
-
L
--
I
---
D
A
---
N
--------
R
W
T
T
S
-----------
I
--
S
-
P
E
----
E
F
K
-----------------
Q
-----
V
T
GTDA
Y
---------------
P
-------------------------------------
D
F
L
-----
K
----
K
D
V
END
T
L
K
V
Y
C
N
-------
G
-------
D
I
V
Y
K
--
I
K
G
V
T
----
A
-----
K
V
S
V
I
--------
W
N
Y
-
T
------
F
-
P
--------
K
--
G
----------
G
G
D
---
T
H
F
S
V
M
K
G
--
S
--
K
A
D
L
V
I
R
Q
G
K
E
Q
N
------------------
Y
------
Q
----------
P
E
-------
L
F
V
E
A
------------------------
V
------
K
--
G
---
V
D
L
---------------------------------------------
A
A
Y
E
----------
K
------------
D
L
------------------------------
T
----------------------------
A
----
S
M
E
K
V
-----
S
A
E
YPG
V
-
A
L
N
-------
K
V
G
D
G
V
-------
W
Q
V
-------------
E
I
P
A
K
Y
----
R
V
G
H
E
A
H
-
F
G
--------
Q
-------
V
-
T
E
-
H
F
L
D
----
Y
L
K
E
-
G
K
L
----
P
D
W
E
-----------------------------------------
V
P
N
M
L
A
K
Y
Y
--
T
T
T
S
A
-------
L
D
M
A
K
A
K
T------------------------------
45
Fugue
63.02
12%
-51
* C3 *
2ZUV
11
LNPA_BIFL2
A:
[3-749]
STGR
F
T
L
P
S
E
E
NF
A
E
K
T
K
E
L
A
E
L
W
GAD
A
I
R
N
S
DAVLALG
K
K
I
Y
N
A
Y
F
PTRAH
N
E
W
I
T
L
H
M
D
E
T
P
Q
V
Y
---
L
L
T
D
R
I
L
A
ESD
T
V
D
I
-----
P
L
MES
F
F
A
E
Q
L
K
P
N
R
D
A
D
P
H
K
Y
W
E
V
V
D
R
T
T
-----------------------------
G
E
V
V
D
S
A
---
N
W
T
L
D
A
D
E
D
T
V
H
--
V
S
GVAAW
H
E
--------------
Y
T
V
S
F
--------
L
A
Y
I
I
W
D
P
V
E
M
Y
N
H
-
L
T
N
DWGDK
E
H
E
I
P
-
F
D
I
Y
H
P
A
T
R
K
-
F
V
F
D
T
--
F
E
Q
W
L
K
D
S
P
Q
----
T
D
V
V
R
F
T
T
F
F
-
Y
Q
F
T
L
L
F
-
D
E
K
---
R
R
E
K
V
V
D
W
F
-
G
C
A
C
T
VS-
P
R
A
L
D
D
F
E
A
K
Y
G
Y
R
L
R
P
E
D
-----
F
V
DGGAYNSAWRVPR
K
A
Q
R
-
D
W
I
--------
D
-
F
L
S
----
G
F
V
R
E
-
N
V
K
Q
L
A
D
M
S
--
H
A
A
G
--
K
E
----
A
M
M
F
-
L
GDQWIGTEPYKDGFDELGLD
A
V
V
G
S
I
G
D
-
G
---
T
T
T
R
M
---
I
A
D
I
P
G
V
K
Y
T
E
------
G
R
F
L
P
--
Y
FFPD
T
F
Y
E
---
G
N
-
D
------
P
S
I
E
G
L
D
-
N
W
R
K
A
R
R
A
I
L
R
---
S
P
IS
R
-------
M
G
Y
G
G
Y
L
-
S
L
-
A
-------
A
K
F
P
K
F
V
D
T
V
T
H
I
A
N
E
---
F
R
--
D
I
H
---
D
-
R
-
T
GGVAA
E
G
E
L
N
V
A
I
L
N
-------------
S
W
GKMRSWMAFTVAHALPN
K
Q
T
Y
---
S
Y
Y
G
-
I
L
---
E
S
---
L
----------
S
-
G
-
M
--
R
---
V
N
---
V
--------
R
F
I
S
F
-----------
D
--
D
V
L
A
----
H
G
I
-----------------
D
SDID
V
I
I
----
N
G
G
P
V
DTAFT------
G
-------------------------------------
G
D
V
-----
W
----
T
N
P
-------
K
L
V
-------
E
-------
T
V
R
A
W
--
V
R
G
G
G
----
A
-----
F
V
G
V
G
--------
E
P
S
-
S
------
A
-
P
--------
R
--
F
----------
Q
T
G
R
F
F
Q
L
A
D
V
-
I
G
--
V
--
D
E
E
R
Y
Q
T
L
S
V
D
K
Y
F
---------
P
P
V
----
V
P
------
D
----------
H
F
-------
I
T
A
D
V
------------------------
P
------
V
--
D
---
P
A
A
---------------------------------------------
R
E
A
W
----------
E
------------
Q
A
G
Y
R
I
P
LSGCGGGQSIKPLGGIDFGEPVLNT
Y
----------------------------
P
VNE-
N
-
V
T
L
-----
L
R
----
A
-
D
G
G
-------
Q
V
Q
L
A
T
-------
N
D
Y
GK
G
R
G
V
Y
I
SGLPY
S
A
-
A
N
A
----
R
L
L
E
R
V
L
F
Y
A
--------
S
-------
H
-
N
E
-
D
K
Y
A
----
A
W
S
S
-
S
N
P
E
C
E
V
A
H
F
P
---
E
Q
G
L
----
Y
----
C
V
---
I
--------------
N
N
T
D
-
Q
P
Q
-
K
T
T
V
T
--
L
A
D
G
T
-------
T
E
-
D
F
D
L
P
DS
G
I
A
W
R-----------------------
22
HHSearch
63.00
18%
-81
- C4 -
1BYR
-
?
A:
[4-150]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Q
V
G
Y
S
P
E
G
S
A
R
---
V
L
V
L
S
A
I
D
S
A
-------
K
T
-----
S
I
---------------
R
M
-
M
A
Y
--------
S
-
F
T
A
----
P
-----
D
I
M
K
A
L
V
A
A
--
K
K
R
G
--
V
D
----
V
K
I
V
-
I
---------------------------
D
-
E
---
R
G
N
T
G
R
--
A
S
I
A
A
M
N
Y
I
A
N
------
S
G
I
P
L
--
R
----
T
D
S
N
---
F
------------------
P
I
Q
H
D
K
V
I
I
V
---
D
N
--
V
-------
T
V
E
T
G
S
F
-
N
F
-
T
-------
K
A
A
E
T
K
N
------
S
E
N
---
A
V
--
V
I
W
---
N
M
P
K
L
-----
A
E
S
F
L
E
H
W
Q
D
-------------
R
W
-----------------
N
Q
G
R
---
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
62.10
23%
-91
- C4 -
1BYR
-
?
A:
[5-152]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----------------
Q
-----
V
G
----
Y
-----------------------------------------------------
S
P
E
------------
G
-------
S
A
R
-------
V
-------
L
V
L
S
A
--
I
D
S
A
K
----
T
-----
S
I
R
M
M
--------
A
Y
S
-
F
------
T
----------
A
--
P
----------
D
I
M
K
A
L
V
A
A
K
K
-
R
G
--
V
--
D
V
K
I
V
I
D
E
R
G
N
T
G
------------
R
----
A
S
------
I
----------
A
A
-------
M
N
Y
I
A
------------------------
N
------
S
--
G
---
I
P
L
---------------------------------------------
R
T
D
S
----------
N
------------
F
P
------------------------------
I
----------------------------
Q
----
H
-
D
K
V
-----
I
I
----
V
-
D
N
V
-------
T
V
E
T
G
S
-------
F
N
F
-------------
T
K
-
A
A
E
----
T
K
N
S
E
N
A
V
V
I
--------
W
-------
N
M
P
K
--
L
A
E
----
S
F
L
E
-
H
W
Q
----
D
R
W
N
---
Q
G
R
D
----
Y
----
R
-------------------------------------------------------------------------------------
38
Fugue
60.08
21%
-71
- C4 -
1BYR
-
?
A:
[2-153]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----
P
S
----
V
---------------
Q
-------------------------------------
V
G
Y
-----
S
----
P
E
G
-------
S
A
R
-------
V
-------
L
V
L
S
A
--
I
D
S
A
K
----
T
-----
S
I
R
M
M
--------
A
Y
S
-
F
--------
T
--------
A
--
P
----------
D
I
M
K
A
L
V
A
A
K
K
-
R
G
--
V
--
D
V
K
I
V
I
D
E
R
G
N
T
G
------------
R
----
A
S
------
I
----------
A
A
-------
M
N
Y
I
A
------------------------
N
------
S
--
G
---
I
P
L
---------------------------------------------
R
T
D
S
----------
N
------------
F
P
------------------------------
I
----------------------------
Q
----
H
-
D
K
V
-----
I
I
----
V
-
D
N
V
-------
T
V
E
T
G
S
-------
F
N
F
-------------
T
K
-
A
A
E
----
T
K
N
S
E
N
A
V
V
I
--------
W
-------
N
-
M
P
-
K
L
A
E
----
S
F
L
E
-
H
W
Q
----
D
R
W
N
---
Q
G
R
D
----
Y
----
R
S
------------------------------------------------------------------------------------
1
PsiBlast_PDB
58.41
26%
-64
- C4 -
1BYR
-
?
A:
[9-143]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
S
----
P
E
G
-------
S
A
R
-------
V
-------
L
V
L
S
A
--
I
D
S
A
K
----
T
-----
S
I
R
M
M
--------
A
Y
S
-
F
------
T
A
P
--------
D
I
M
K
----------
A
L
V
A
A
K
K
R
-----
G
--
V
--
D
V
K
I
V
I
D
E
R
G
N
T
G
------------
R
----
A
S
------
I
----------
A
A
-------
M
N
Y
I
A
------------------------
N
------
S
--
G
---
I
P
L
---------------------------------------------
R
T
D
S
----------
N
------------
F
P
------------------------------
I
----------------------------
Q
----
H
-
D
K
V
-----
I
I
----
V
-
D
N
V
-------
T
V
E
T
G
S
-------
F
N
F
-------------
T
K
-
A
A
E
----
T
K
N
S
E
N
A
V
V
I
--------
W
-------
N
------
M
P
----
K
L
A
E
-
S
F
L
----
E
H
W
Q
---
D
--------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.36
26%
-62
- C4 -
1BYS
1
?
A:
[9-143]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
S
----
P
E
G
-------
S
A
R
-------
V
-------
L
V
L
S
A
--
I
D
S
A
K
----
T
-----
S
I
R
M
M
--------
A
Y
S
-
F
------
T
A
P
--------
D
I
M
K
----------
A
L
V
A
A
K
K
R
-----
G
--
V
--
D
V
K
I
V
I
D
E
R
G
N
T
G
------------
R
----
A
S
------
I
----------
A
A
-------
M
N
Y
I
A
------------------------
N
------
S
--
G
---
I
P
L
---------------------------------------------
R
T
D
S
----------
N
------------
F
P
------------------------------
I
----------------------------
Q
----
H
-
D
K
V
-----
I
I
----
V
-
D
N
V
-------
T
V
E
T
G
S
-------
F
N
F
-------------
T
K
-
A
A
E
----
T
K
N
S
E
N
A
V
V
I
--------
W
-------
N
------
M
P
----
K
L
A
E
-
S
F
L
----
E
H
W
Q
---
D
--------------------------------------------------------------------------------------------------
26
HHSearch
55.50
18%
-87
- C4 -
1V0W
1
?
A:
[65-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
R
L
L
-------
A
-------
K
M
T
E
N
--
I
G
N
A
T
----
R
-----
T
V
D
I
S
--------
T
L
A
P
F
------
P
-
N
G
A
F
-----
Q
--
D
----------
A
I
V
A
G
L
K
E
S
A
A
-
K
G
N
K
L
--
K
V
R
I
L
V
G
A
A
P
--
H
M
---------
N
V
-----
I
P
------
S
----------
K
Y
-------
R
D
E
L
T
------------------------
A
K
L
G
K
A
A
E
--
N
---
I
T
L
---------------------------------------------
N
V
A
S
M
T
TSKT----
A
------------
F
S
------------------------------
W
----------------------------
N
----
H
-
S
K
I
-----
L
V
----
V
-
D
G
Q
-------
S
A
L
T
G
G
-------
I
N
S
-------------
W
K
-
D
D
Y
LDTT
H
P
V
S
D
V
D
L
A
L
--------
T
-------
G
--
P
--
A
A
G
----
S
A
G
R
-
Y
L
D
----
T
L
W
T
---
W
T
C
Q
-----------------------------------------------------------------------------------------------
23
HHSearch
55.28
22%
-71
- C4 -
1XDP
3
PPK_ECOLI
A:
[347-498]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
F
-------
E
-------
H
V
L
E
L
--
L
R
Q
A
S
----
F
DPSVL
A
I
K
I
N
--------
I
Y
R
-
V
------
A
-
K
--------
D
--
S
----------
R
I
I
D
S
M
I
H
A
A
H
-
N
G
--
K
--
K
V
T
V
V
V
E
L
Q
A
R
F
-----------
D
E
E
----
A
N
------
I
----------
H
W
-------
A
K
R
L
T
------------------------
E
------
A
--
G
---
V
H
V
---------------------------------------------
I
F
S
A
----------
P
------------
G
L
------------------------------
K
----------------------------
I
----
H
-
A
K
L
-----
F
L
----
I
-
S
R
K
E
NG
E
V
V
R
Y
A
H
I
G
T
-------
G
N
F
-------------
N
E
-
K
T
A
----
R
L
Y
T
D
Y
S
L
L
T
--------
A
-------
D
-
A
R
--
I
T
N
----
E
V
R
R
-
V
F
N
----
F
I
E
N
---
P
Y
R
P
----
V
----
T
-------------------------------------------------------------------------------------
41
Fugue
54.93
12%
-61
- C2 -
1C0P
4
OXDA_RHOTO
A:
[1-363]
----------------------------------------------------------------------------------------------------
L
M
M
H
S
Q
K
R
V
V
V
L
G
S
G
---
V
I
-----------------------------
G
L
S
S
A
L
I
---
L
A
R
K
G
-----------------------------------------------------
Y
S
V
H
I
L
-
A
R
D
-----
L
P
E
D
V
-
S
S
Q
T
F
A
S
P
W
A
-
G
A
N
W
T
--
P
F
M
-
T
L
T
D
G
P
----
R
Q
A
K
W
E
E
S
T
F
-
K
K
W
V
E
L
V
-
P
--------
T
G
H
A
M
W
-
L
K
G
T
R
---
R
F
A
Q
N
E
D
G
L
L
-------
G
H
-----
W
Y
---------------
K
D
-
I
T
P
--------
N
-
Y
R
P
-------
L
P
-
S
S
E
C
--
P
P
G
--
A
-
I
G
--
V
T
----
Y
D
T
L
-
S
---------------------------------
V
H
A
P
K
---
Y
C
Q
Y
L
A
R
E
L
Q
K
------
L
G
A
T
F
--
E
----
R
R
T
V
---
T
S
-----------
L
E
Q
A
-
F
D
-
G
A
D
L
V
V
N
A
---
T
G
---------------------------------
L
G
A
K
S
I
A
G
I
D
D
Q
---
A
A
--
E
P
I
---
R
-
G
-
Q
-----
T
V
L
V
K
S
P
-
C
K
-------------
R
C
-----------------
T
M
D
S
---
S
D
P
-------------------------
A
---------
S
---
P
--------
A
Y
I
I
P
-----------
R
--
P
G
G
-------------------------
E
-----
V
I
----
C
---------------
G
-------------------------------------
G
T
Y
-----
G
----
V
G
D
-------
W
D
L
-------
S
-------
V
N
P
E
T
--
V
Q
R
I
L
----
K
-----
H
C
L
R
L
--------
D
P
T
-
I
------
S
-
S
--------
D
--
G
----------
T
I
E
G
I
--
E
V
L
R
-
H
N
--
V
--
G
L
R
P
A
R
R
G
-----------------------
G
------
P
----------
R
V
-------
E
A
E
R
I
------------------------
V
------
L
--
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
D
R
T
-------
K
S
P
L
S
L
-------
G
R
G
-------------
S
A
-
R
A
A
----
K
E
K
E
V
T
L
V
H
A
--------
Y
-------
G
-
F
S
-----------------------------
S
A
G
----
Y
----
Q
Q
---
S
--------------
W
G
A
A
-
E
D
V
-
A
Q
L
V
D
--
E
A
F
Q
R
-------
Y
H
-
G
----------------------------------
24
HHSearch
51.86
12%
-72
- C4 -
2C1L
5
?
A:
[21-165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
M
L
E
-------
N
-------
V
W
V
S
N
--
H
T
P
G
E
----
G
-----
T
L
Y
L
I
--------
S
G
F
-
S
------
N
-
Y
--------
N
--
G
GV--------
R
F
Y
E
T
F
T
E
H
I
N
-
Q
G
--
G
--
R
V
I
A
I
L
G
G
S
T
S
Q
R
L
---------
S
-------
S
------
R
----------
Q
V
-------
V
E
E
L
L
------------------------
N
------
R
--
G
---
V
E
V
---------------------------------------------
H
I
I
N
----------
R
------------
K
R
------------------------------
I
----------------------------
L
----
H
-
A
K
L
-----
Y
G
----
T
-
S
N
N
L
G
E
----
S
L
V
V
S
S
-------
G
N
F
-------------
T
G
-
P
G
M
----
S
Q
N
I
E
A
S
L
L
L
--------
D
-------
N
-
N
T
--
T
Q
S
M
GF-
S
W
N
D
-
M
I
S
----
E
M
L
N
---
Q
N
W
------------------------------------------------------------------------------------------------
28
HHSearch
51.19
13%
-76
- C4 -
2C1L
5
?
A:
[23-144]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
---
N
V
W
V
S
N
H
T
P
G
-------
E
G
-----
T
L
---------------
Y
L
-
I
S
G
--------
F
-
S
N
Y
----
N
G
G
-
V
-
R
F
Y
E
T
F
T
E
H
--
I
N
Q
G
--
G
R
----
V
I
A
I
-
L
---------------------------
G
-
G
---
S
T
S
Q
R
L--
S
S
R
Q
V
V
E
E
L
L
N
------
R
G
V
E
V
--
H
----
I
I
N
R
---------------------
K
R
I
L
H
A
K
L
Y
G
T
---
S
N
--
N
L
G
E
----
S
L
V
V
S
S
G
-
N
F
-
T
-------
G
P
G
M
S
Q
N
------
I
E
A
---
S
L
--
L
L
D
---
N
-
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------