@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0030: (2016-03-11 )
LEKYLICSDLDGTLLLKNQTISPKTLNLLQQLIEEGHHFAVSTGRMYNSATDFAKLVHPKADVIASNGGVVAVSGEIIQQEKMKQSALLETFLLCQNHDLPVFFFSTDTVFYTKNPPYYFTDEEDKGRVNATKLVAIKSREIFLEHADQFINGIVIEEEDFDKLAVLRSDLEKLSDVSILSSHANNIEILPKDMDKKYAVKNLAAHLNIKPENVITFGDGENDIGMLEVAGAGVAMENASELVKKSADFVTTANDADGIYYFLKKHLNR
Atome Classification :
(20 SA)
....-.....10....-..-.-.-20-........30......-..40........50...---..--.-.---.---60--......--..-70--..--.--..-...80........90..-......--100......-.110....-.---.-.120-.-....-.---------.----------------.--130...-...---.140..----...-------..150....--...------------------160.......-..170.--..-----.--...-..180.......190.......200.......210.......220.......230.......240.......250.......260.......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LE
K
Y
-
L
I
CSDLD
G
T
L
L
-
L
K-N-Q-TI-S
P
K
T
L
N
L
L
Q
Q
L
I
EEGH-
H
F
A
V
STGRMYN
S
A
T
D
F
A
---
K
L
--V-H---P---KA--
D
V
I
ASN--G
G
-
V
V
--
A
V--S--
G
E
-
I
I
Q
Q
E
K
M
K
Q
S
A
L
L
E
T
F
L
-
L
CQNHD--L
P
V
F
F
F
ST
D
-
T
V
F
Y
TKNP-
P
---
Y
-
Y
F-T-D-EEDK-G---------R----------------V--N
A
T
K
L
V
-
A
I
K---
S
R
E
I
F
L
----
E
H
A
-------
D
Q
FIN
G
I
V
I--EEE------------------D--
F
D
K
L
A
V
L
-
R
S
D
--
L
--
E
K
-----
L
--
S
D
V
-
S
I
L
S
SHAN
N
I
E
ILPKDM
D
K
K
Y
A
V
K
N
L
A
A
HLNIKPE
N
V
I
T
FGDGEND
I
G
M
L
E
VAGAGVAME
N
A
S
E
L
V
K
KSA
D
F
V
TTANDA
D
G
I
Y
Y
F
L
K
K
HLNR---
21
PsiBlast_CBE
89.37
33%
-69
- C2 -
1RKQ
2
YIDA_ECOLI
B:
[7-270]
-----
L
I
A
I
D
M
D
G
T
L
L
-
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
-
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
---
K
E
--
L
-
H
MEQ
P
---
G
D
--
Y
C
I
T
Y
N
--
G
A
-
L
V
QK
A
A
--
D
--
G
S
-
T
V
A
Q
T
A
L
S
Y
D
D
Y
--
R
F
L
-
E
K
L
S
R
E
--
V
G
S
H
F
H
A
L
D
R
T
T
L
Y
T
A
N
R
-
D
---
I
S
Y
Y
-
T
-
V
-
H
E
S
------------
F
----------------
V
--
A
T
I
P
L
V
-
F
C
E
---
A
E
K
--
M
----
D
P
N
-------
T
Q
F
L
K
V
M
M
I
--
D
E
P
------------------
A
--
I
L
D
Q
A
I
A
-
R
I
P
--
Q
--
E
V
-----
K
--
E
K
Y
-
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
-----
1
PsiBlast_PDB
88.20
33%
-67
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[7-270]
-----
L
I
A
I
D
M
D
G
T
L
L
-
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
-
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
---
K
E
--
L
-
H
MEQ
P
---
G
D
--
Y
C
I
T
Y
N
--
G
A
-
L
V
Q
K
A
A
--
D
--
G
S
-
T
V
A
Q
T
A
L
S
Y
D
D
Y
--
R
F
L
-
E
K
L
S
R
E
--
V
G
S
H
F
H
A
L
D
R
T
T
L
Y
T
A
N
R
-
D
---
I
S
Y
Y
-
T
-
V
-
H
E
S
------------
F
----------------
V
--
A
T
I
P
L
V
-
F
C
E
---
A
E
K
--
M
----
D
P
N
-------
T
Q
F
L
K
V
M
M
I
--
D
E
P
------------------
A
--
I
L
D
Q
A
I
A
-
R
I
P
--
Q
--
E
V
-----
K
--
E
K
Y
-
T
V
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
-----
7
PsiBlast_PDB
87.35
29%
-67
- C2 -
3R4C
4
?
A:
[18-263]
---------
D
V
D
G
T
L
L
S
F
E
-
T
-
H
-
K
V
-
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
-
K
I
V
I
A
T
G
R
---
A
A
S
D
L
H
---
E
I
D-
A
-
V
---
P
---
Y
D
--
G
V
I
A
L
N
--
G
A
E
C
V
--
L
R
--
D
--
G
S
-
V
I
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
-
L
A
R
E
F
D
--
F
A
V
A
L
E
L
N
E
-
G
V
F
V
N
R
L
T
-
P
--------
T
-
V
-
E
Q
I
A
-
G
---------
I
----------------
V
--
E
H
P
V
P
P
-
V
V
D
---
I
E
E
M
F
-----
E
R
K
-------
E
C
C
Q
L
C
F
Y
F
--
D
E
E
------------------
A
--
E
Q
K
V
M
P
L
----------------
L
--
S
G
L
-
S
A
T
R
W
H
P
L
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
--------
2
PsiBlast_PDB
87.31
30%
-85
- C2 -
1NF2
3
?
A:
[8-260]
---------
D
L
D
G
T
L
L
-
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
I
E
K
L
-
S
R
K
C
-
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
---
K
K
--
Y
-
F
---
K
---
R
T
F-
P
T
I
A
Y
N
--
G
A
-
I
V
--
Y
L
--
P
--
E
E
G
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
-
Y
I
K
P
L
N
--
V
H
W
Q
A
Y
I
D
D
-
V
L
Y
S
E
K
D
-------------
N
-
E
E
I
K
-
S
Y
A
R
H
S
N
V
D
Y
R
----------------
V
E
P
N
L
S
E
L
V
-
S
K
M
---
G
T
T
K
L
L
--------------------
L
I
D
--
T
P
E
------------------
R
--
L
D
E
L
K
E
I
-
L
S
------
E
R
-----
F
--
K
D
V
V
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
-------
174
HHSearch
86.70
31%
-72
- C2 -
1RKQ
2
YIDA_ECOLI
A:
[3-271]
L
A
I
K
-
L
I
A
I
D
M
D
G
T
L
L
-
L
P
-
D
-
H
-
T
I
-
S
P
A
V
K
N
A
I
A
A
A
R
A
R
G
V
-
N
V
V
L
T
T
G
R
P
Y
A
G
V
H
N
Y
L
---
K
E
--
L
-
H
---
M
EQP
G
D
--
Y
C
I
T
Y
N
--
G
A
-
L
V
--
Q
K
--
A
AD
G
S
-
T
V
A
Q
T
A
L
S
Y
D
D
Y
R
F
L
E
K
-
L
S
R
E
V
G
--
S
H
F
H
A
L
D
R
T
-
T
L
Y
T
A
N
R
D
-
I
---
S
-
Y
Y
-
T
V
H
-
E
S
F
V
-
A
---------
T
----------------
I
----
P
L
V
F
C
E
A
E
---
K
---
M
-----
D
P
N
-------
T
Q
F
L
K
V
M
M
I
--
D
E
P
------------------
A
I
L
D
Q
A
I
A
R
I
-
P
Q
E
--
V
--
K
E
-----
K
--
Y
T
V
---
L
K
S
A
P
Y
F
L
E
I
L
D
K
R
V
N
K
G
T
G
V
K
S
L
A
D
V
L
G
I
K
P
E
E
I
M
A
I
G
D
Q
E
N
D
I
A
M
I
E
Y
A
G
V
G
V
A
V
D
N
A
I
P
S
V
K
E
V
A
N
F
V
T
K
S
N
L
E
D
G
V
A
F
A
I
E
K
Y
V
L
----
159
Fugue
86.53
26%
-73
- C2 -
1NF2
3
?
A:
[1-267]
-
M
Y
R
-
V
F
V
F
D
L
D
G
T
L
L
-
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
I
E
K
L
-
S
R
K
C
-
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
---
K
K
--
Y
F
K
---
R
---
T
F
--
P
T
I
A
Y
N
--
G
A
-
I
V
--
Y
L
P-
E
--
E
G
-
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
-
Y
I
K
P
L
N
--
V
H
W
Q
A
Y
I
D
D
-
V
L
Y
S
E
K
D
N
-
E
---
E
-
I
K
-
S
-
Y
-
A
R
H
S
-
N
---------
V
--------------------------
D
Y
R
---
V
E
P
N
L
S
----
E
L
V
-------
S
K
M
G
T
T
K
L
L
--
L
I
D
------------------
T
--
P
E
R
L
D
E
L
-
K
E
I
--
L
--
S
E
-----
R
FK
D
V
V
-
K
V
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
T
D
CLD
171
HHSearch
85.35
28%
-65
- C2 -
1NRW
3
YWPJ_BACSU
A:
[4-288]
--
M
K
-
L
I
A
I
D
L
D
G
T
L
L
-
N
S
-
K
-
H
-
Q
V
-
S
L
E
N
E
N
A
L
R
Q
A
Q
R
D
G
I
-
E
V
V
V
S
T
G
R
A
H
F
D
V
M
S
I
F
---
E
P
--
L
-
G
---
I
---
K
T
--
W
V
I
S
A
N
--
G
A
-
V
I
--
H
D
--
P
E-
G
R
-
L
Y
H
H
E
T
I
D
K
K
R
A
Y
D
I
L
S
-
W
L
E
S
E
N
--
Y
Y
Y
E
V
F
T
G
S
-
A
I
Y
T
P
Q
N
G
R
E
L
L
-
D
-
V
E
-
L
-
D
--
R
F
R
-
S
---------
A
NPEAD
L
S
V
L
K
Q
A
A
E
V
Q
Y
--
S
Q
S
G
F
A
-
Y
I
N
---
S
F
Q
E
L
F
EA--
D
E
P
-------
I
D
F
Y
N
I
L
G
F
--
S
F
F
------------------
K
--
E
K
-
L
E
A
G
-
W
K
R
YE
H
--
A
E
-----
D
--
L
T
L
---
V
S
S
A
E
H
N
F
E
L
S
S
R
K
A
S
K
G
Q
A
L
K
R
L
A
K
Q
L
N
I
P
L
E
E
T
A
A
V
G
D
S
L
N
D
K
S
M
L
E
A
A
G
K
G
V
A
M
G
N
A
R
E
D
I
K
S
I
A
D
A
V
T
L
T
N
D
E
H
G
V
A
H
M
M
K
H
L
L
-----
178
HHSearch
84.65
27%
-81
- C2 -
1NF2
3
?
A:
[1-262]
-
M
Y
R
-
V
F
V
F
D
L
D
G
T
L
L
-
N
D
-
N
-
L
-
E
I
-
S
E
K
D
R
R
N
I
E
K
L
S
R
-
K
C
-
Y
V
V
F
A
S
G
R
M
L
V
S
T
L
N
V
E
---
K
K
Y
-
F
-
K
---
R
---
T
F
--
P
T
I
A
Y
N
--
G
A
-
I
V
--
Y
L
--
P
E-
E
G
-
V
I
L
N
E
K
I
P
P
E
V
A
K
D
I
I
E
-
Y
I
K
P
L
N
--
V
H
W
Q
A
Y
I
D
D
-
V
L
Y
S
E
K
D
N
-
E
E
I
-
K
-
S
Y
-
A
-
R
---
H
S
-
N
-------------------------------
V
D
Y
R
-
V
E
P
---
N
L
S
E
L
V
----
S
K
--------
M
G
T
T
K
L
L
L
I
--
D
T
P
E
R
----------------
L
--
D
E
L
K
E
I
L
-
S
E
R
--
F
--
K
D
-----
V
--
V
K
V
---
F
K
S
F
P
T
Y
L
E
I
V
P
K
N
V
D
K
G
K
A
L
R
F
L
R
E
R
M
N
W
K
K
E
E
I
V
V
F
G
D
N
E
N
D
L
F
M
F
E
E
A
G
L
R
V
A
M
E
N
A
I
E
K
V
K
E
A
S
D
I
V
T
L
T
N
N
D
S
G
V
S
Y
V
L
E
R
I
S
-----
181
HHSearch
84.53
26%
-77
- C2 -
3R4C
4
?
A:
[10-267]
H
M
I
K
-
V
L
L
L
D
V
D
G
T
L
L
-
S
F
E
T
-
H
-
K
V
-
S
Q
S
S
I
D
A
L
K
K
V
H
D
S
G
I
-
K
I
V
I
A
T
G
R
A
A
S
D
L
H
E
I
D
----
A
--
V
-
P
-------
Y
D
--
G
V
I
A
L
N
--
G
A
-
E
C
--
V
L
--
R
D-
G
S
-
V
I
R
K
V
A
I
P
A
Q
D
F
R
K
S
M
E
-
L
A
R
E
F
D
--
F
A
V
A
L
E
L
N
E
-
G
V
F
V
N
R
L
T
-
P
T
V
-
E
-
Q
I
-
A
-
G
--
I
V
E
-
H
---------
P
----------------
V
----
P
P
V
V
-
D
I
E
---
E
---
M
F
----
E
R
--------
K
E
C
C
Q
L
C
F
Y
--
F
D
E
---------------------
E
A
-
E
Q
K
V
-
M
P
L
--
L
--
S
------
G
--
L
S
A
---
T
R
W
H
P
L
F
A
D
V
N
V
A
G
T
S
K
A
T
G
L
S
L
F
A
D
Y
Y
R
V
K
V
S
E
I
M
A
C
G
D
G
G
N
D
I
P
M
L
K
A
A
G
I
G
V
A
M
G
N
A
S
E
K
V
Q
S
V
A
D
F
V
T
D
T
V
D
N
S
G
L
Y
K
A
L
K
H
F
G
V
----
169
HHSearch
83.57
22%
-71
- C2 -
3FZQ
7
?
A:
[4-272]
-
L
Y
K
-
L
L
I
L
D
I
D
G
T
L
R
-
D
E
-
V
-
Y
-
G
I
-
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
-
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
---
L
S
--
L
-
G
---
V
----
D
--
G
Y
I
A
G
G
--
G
N
-
Y
I
--
Q
Y
--
H
--
G
E
-
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
-
L
L
K
K
R
E
--
V
A
F
S
I
E
S
Q
E
-
K
V
F
M
N
Q
K
A
-
K
---
E
-
I
F
-
E
-
T
M
N
Q
L
K
-
G
TNSCINKQ-
H
----------------
I
--
Q
-
E
K
I
T
-
Y
E
N
---
N
I
E
E
Y
-----
K
S
--------
Q
D
I
H
K
I
C
L
W
--
S
N
E
---------------------
K
V
-
F
D
E
V
-
K
D
I
--
L
--
Q
D
-----
K
--
M
E
L
-
A
Q
R
D
I
S
S
Q
Y
Y
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
N
-----
15
PsiBlast_PDB
83.34
25%
-61
- C2 -
3FZQ
7
?
A:
[7-271]
-----
L
L
I
L
D
I
D
G
T
L
R
-
D
E
-
V
-
Y
-
G
I
--
P
E
S
A
K
H
A
I
R
L
C
Q
K
N
H
C
S
V
V
I
C
T
G
R
S
M
G
T
I
Q
D
D
V
----
L
--
S
-
L
---
G
---
V
D
--
G
Y
I
A
G
G
--
G
N
-
Y
I
--
Q
Y
--
H
--
G
E
-
L
L
Y
N
Q
S
F
N
Q
R
L
I
K
E
V
V
C
-
L
L
K
K
R
E
--
V
A
F
S
I
E
S
Q
E
-
K
V
F
M
N
Q
K
A
-
K
---
E
-
I
F
E
T
-
M
-
N
Q
L
K
-
G
---------
T
----------------
N
--
S
C
I
N
K
Q
-
H
I
Q
---
E
K
I
T
Y
E
NNIE
E
Y
K
-------
S
Q
D
I
H
K
I
C
L
W
S
N
E
K
------------------
V
--
F
D
E
V
K
D
I
-
L
Q
D
--
K
--
M
E
-----
L
--
A
Q
R
-
D
I
S
S
Q
Y
Y
---
E
I
I
Q
K
D
F
H
K
G
K
A
I
K
R
L
Q
E
R
L
G
V
T
Q
K
E
T
I
C
F
G
D
G
Q
N
D
I
V
M
F
Q
A
S
D
V
T
I
A
M
K
N
S
H
Q
Q
L
K
D
I
A
T
S
I
C
E
D
I
F
D
N
G
I
Y
K
E
L
K
R
R
------
4
PsiBlast_PDB
81.88
26%
-67
* C3 *
4DW8
4
?
A:
[4-269]
--
K
Y
K
L
I
V
L
D
L
D
G
T
L
T
-
N
S
-
K
-
K
-
E
I
-
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
-
R
L
V
L
A
S
G
R
P
T
Y
G
I
V
P
L
A
N
E
L
R
M
--
N
-
E
---
F
---
G
G
--
F
I
L
S
Y
N
--
G
G
-------------
E
-
I
I
N
W
E
S
--
K
E
M
M
Y
E
N
V
L
---
P
N
E
V
--
V
P
V
L
Y
-----------------------------
E
C
-
A
---------
R
----------------
T
--
N
H
L
S
I
L
-
T
Y
D
---
G
A
E
I
V
T
----
E
N
S
LD
P
Y
V
Q
K
E
A
F
L
N
K
M
A
I
--
R
E
T
NDFLTDITLPVA
K
C
L
I
V
G
D
--
A
G
K
L
I
P
V
-
E
S
E
--
L
C
I
R
L
-----
Q
--
G
K
I
-
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----
11
PsiBlast_PDB
81.71
25%
-63
- C2 -
2RBK
2
?
A:
[8-256]
---------
D
I
D
G
T
L
V
S
F
E
-
T
-
H
-
R
I
-
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
-
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
---
E
L
--
Q
-
D
---
R
---
N
L
ID
G
Y
I
T
M
N
--
G
A
-
Y
C
--
F
V
--
G
--
E
E
-
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
-
F
C
E
K
K
G
--
V
P
C
I
F
V
E
E
H
-
N
I
S
V
C
Q
P
N
-
E
---
M
-
V
K
-
K
-
I
-
F
Y
D
F
-
L
---------
H
----------------
V
--
N
V
I
P
T
V
-
S
F
E
E
A
S
N
K
E
V
I
Q
-----------------
M
T
P
F
I
T
--
E
E
E
------------------
E
----------
K
E
V
--
L
--
P
S
-----
I
--
P
T
C
-
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
--------
176
HHSearch
81.62
22%
-76
- C2 -
3DAO
1
?
A:
[19-283]
G
M
I
K
-
L
I
A
T
D
I
D
G
T
L
V
-
K
D
-
G
-
S
L
L
I
-
D
P
E
Y
M
S
V
I
D
R
L
I
D
K
G
I
-
I
F
V
V
C
S
G
R
Q
F
S
S
E
F
K
L
F
---
A
P
--
I
-
K
---
H
---
K
L
--
L
Y
I
T
D
G
--
G
T
-
V
V
--
R
T
--
P
--
K
E
-
I
L
K
T
Y
P
M
D
E
D
I
W
K
G
M
C
R
-
M
V
R
D
E
L
PA
C
D
Y
F
A
A
T
P
D
-
F
C
F
A
E
D
G
G
-
S
---
P
-
I
F
-
H
----
L
L
R
-
D
---------
S
----------------
Y
--
G
-
F
E
M
R
-
E
V
D
---
D
I
T
R
L
-----
D
R
--------
N
D
I
I
K
F
T
V
F
--
H
P
D
K-----------------
C
--
E
E
L
C
T
P
V
F
I
P
A
--
W
--
N
K
-----
K
--
A
H
L
---
A
A
A
G
K
E
W
V
D
C
N
A
K
G
V
S
K
W
T
A
L
S
Y
L
I
D
R
F
D
L
L
P
D
E
V
C
C
F
G
D
N
L
N
D
I
E
M
L
Q
N
A
G
I
S
Y
A
V
S
N
A
R
Q
E
V
I
A
A
A
K
H
T
C
A
P
Y
W
E
N
G
V
L
S
V
L
K
S
F
L
-----
180
HHSearch
81.61
24%
-62
* C2 *
2RBK
2
?
A:
[1-260]
-
M
T
K
-
A
L
F
F
D
I
D
G
T
L
V
-
S
F
-
E
T
H
-
R
I
-
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
-
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
---
E
L
Q
D
R
-
N
---
L
---
I
D
--
G
Y
I
T
M
N
--
G
A
-
Y
C
--
F
V
--
G
--
E
E
-
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
-
F
C
E
K
K
G
--
V
P
C
I
F
V
E
E
H
-
N
I
S
V
C
Q
P
N
-
E
M
V
K
K
-
I
F
-
Y
-
D
--
F
L
H
V
N
---------
V
----------------
I
----
P
T
V
--
S
F
E
---
E
---
A
-----
S
N
--------
K
E
V
I
Q
M
T
P
F
--
I
T
E
------------------
E
---
E
-
E
K
E
V
-
L
P
S
--
I
--
P
------
T
--
C
E
I
---
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
H
F
G
I
----
9
PsiBlast_PDB
81.58
25%
-64
- C2 -
1YMQ
3
?
A:
[8-256]
---------
D
I
D
G
T
L
V
S
F
E
-
T
-
H
-
R
I
-
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
-
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
---
E
L
--
Q
-
D
---
R
---
N
L
ID
G
Y
I
T
M
N
--
G
A
-
Y
C
--
F
V
--
G
--
E
E
-
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
-
F
C
E
K
K
G
--
V
P
C
I
F
V
E
E
H
-
N
I
S
V
C
Q
P
N
-
E
---
M
-
V
K
-
K
-
I
-
F
Y
D
F
-
L
---------
H
----------------
V
--
N
V
I
P
T
V
-
S
F
E
E
A
S
N
K
E
V
I
Q
-----------------
M
T
P
F
I
T
--
E
E
E
------------------
E
----------
K
E
V
--
L
--
P
S
-----
I
--
P
T
C
-
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
--------
10
PsiBlast_PDB
81.53
25%
-65
- C2 -
2RB5
2
?
A:
[8-256]
---------
D
I
D
G
T
L
V
S
F
E
-
T
-
H
-
R
I
-
P
S
S
T
I
E
A
L
E
A
A
H
A
K
G
L
-
K
I
F
I
A
T
G
R
P
K
A
I
I
N
N
L
S
---
E
L
--
Q
-
D
---
R
---
N
L
ID
G
Y
I
T
M
N
--
G
A
-
Y
C
--
F
V
--
G
--
E
E
-
V
I
Y
K
S
A
I
P
Q
E
E
V
K
A
M
A
A
-
F
C
E
K
K
G
--
V
P
C
I
F
V
E
E
H
-
N
I
S
V
C
Q
P
N
-
E
---
M
-
V
K
-
K
-
I
-
F
Y
D
F
-
L
---------
H
----------------
V
--
N
V
I
P
T
V
-
S
F
E
E
A
S
N
K
E
V
I
Q
-----------------
M
T
P
F
I
T
--
E
E
E
------------------
E
----------
K
E
V
--
L
--
P
S
-----
I
--
P
T
C
-
E
I
G
R
W
Y
P
A
F
A
D
V
T
A
K
G
D
T
K
Q
K
G
I
D
E
I
I
R
H
F
G
I
K
L
E
E
T
M
S
F
G
D
G
G
N
D
I
S
M
L
R
H
A
A
I
G
V
A
M
G
Q
A
K
E
D
V
K
A
A
A
D
Y
V
T
A
P
I
D
E
D
G
I
S
K
A
M
K
--------
6
PsiBlast_PDB
80.46
25%
-66
- C2 -
2QYH
5
?
A:
[3-253]
--
R
K
-
I
V
F
F
D
I
D
G
T
L
L
-
D
E
-
Q
-
K
-
Q
L
-
P
L
S
T
I
E
A
V
R
R
L
K
Q
S
G
V
-
Y
V
A
I
A
T
G
R
A
P
F
M
F
E
H
V
R
---
K
Q
--
L
-
G
---
I
---
D
S
---
F
V
S
F
N
--
G
Q
-
Y
V
--
V
F
--
E
--
G
N
-
V
L
Y
K
Q
P
L
R
R
E
K
V
R
A
--
L
-
T
E
E
A
H
-----------------
K
N
G
H
-
P
---
L
-
V
F
-
M
-
D
-
A
E
-
K
-
M
---------
R
----------------
A
--
S
I
G
D
H
P
-
H
I
H
---
V
S
M
A
S
L
----
K
F
A
-------
H
P
P
V
D
P
L
Y
Y
--
E
N
K
------------------
D
I-
Y
Q
A
L
L
F
C
-
R
A
E
--
E
--
E
E
P
Y
V
R
N
Y
--
P
E
F
-
R
F
V
R
W
H
D
V
S
T
D
V
L
P
A
G
G
S
K
A
E
G
I
R
M
M
I
E
K
L
G
I
D
K
K
D
V
Y
A
F
G
D
G
L
N
D
I
E
M
L
S
F
V
G
T
G
V
A
M
G
N
A
H
E
E
V
K
R
V
A
D
F
V
T
K
P
V
D
K
E
G
I
W
Y
G
L
K
Q
-------
173
HHSearch
80.38
21%
-77
- C2 -
1RLM
3
SUPH_ECOLI
A:
[2-264]
-
A
V
K
-
V
I
V
T
D
M
D
G
T
F
L
-
N
D
-
A
-
K
-
T
Y
N
Q
P
R
F
M
A
Q
Y
Q
E
L
K
K
R
G
I
-
K
F
V
V
A
S
G
N
Q
Y
Y
Q
L
I
S
F
F
---
P
E
--
L
-
K
---
D
---
E
I
--
S
F
V
A
E
N
--
G
A
-
L
V
--
Y
E
--
H
--
G
K
-
Q
L
F
H
G
E
L
T
R
H
E
S
R
I
V
I
G
E
L
L
K
D
K
Q
--
L
N
F
V
A
C
G
L
Q
-
S
A
Y
V
S
E
N
A
P
E
---
A
-
F
V
-
A
----
L
M
A
-
K
---------
H
----------------
Y
----
H
R
L
K
-
P
V
K
---
D
---
Y
-----
Q
E
I
D------
D
V
L
F
K
F
S
L
N
--
L
P
D
EQ----------------
I
--
P
L
V
I
D
K
L
-
H
V
A
--
L
--
D
G
-----
I
--
M
K
P
---
V
T
S
G
F
G
F
I
D
L
I
I
P
G
L
H
K
A
N
G
I
S
R
L
L
K
R
W
D
L
S
P
Q
N
V
V
A
I
G
D
S
G
N
D
A
E
M
L
K
M
A
R
Y
S
F
A
M
G
N
A
A
E
N
I
K
Q
I
A
R
Y
A
T
D
D
N
N
H
E
G
A
L
N
V
I
Q
A
V
L
D
----
8
PsiBlast_PDB
79.95
26%
-69
- C3 -
3NIW
2
?
A:
[4-269]
-
K
Y
K
-
L
I
V
L
D
L
D
G
T
L
T
-
N
S
-
K
-
K
-
E
I
-
S
S
R
N
R
E
T
L
I
R
I
Q
E
Q
G
I
-
R
L
V
L
A
S
G
R
P
T
Y
G
------------
I
-
V
---
P
---
L
A
--
N
E
L
R
M
N
EF
G
G
-
F
I
--
L
S
YN
G
--
G
E
-
I
I
N
W
E
S
--
K
E
M
M
Y
E
N
V
L
---
P
N
E
V
--
V
P
V
L
Y
-----------------------------
E
C
-
A
---------
R
----------------
T
--
N
H
L
S
I
L
-
T
Y
D
---
G
A
E
I
V
T
----
E
N
S
LD
P
Y
V
Q
K
E
A
F
L
N
K
M
A
I
--
R
E
T
NDFLTDITLPVA
K
C
L
I
V
G
D
--
A
G
K
L
I
P
V
-
E
S
E
--
L
C
I
R
L
-----
Q
--
G
K
I
-
N
V
F
R
S
E
P
Y
F
L
E
L
V
P
Q
G
I
D
K
A
L
S
L
S
V
L
L
E
N
I
G
M
T
R
E
E
V
I
A
I
G
D
G
Y
N
D
L
S
M
I
K
F
A
G
M
G
V
A
M
G
N
A
Q
E
P
V
K
K
A
A
D
Y
I
T
L
T
N
D
E
D
G
V
A
E
A
I
E
R
I
F
-----