@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0491: (2016-03-16 )
MNKVVVKNVTFGEGAPKICVPMVGKTVAALKEEAEMLQTIDLDVVEWRVDFFEDVKDLAKVEAALGEIRAILPETPILFTFRSAKEGGELAVSDEFYFELNETLAGTGKIDLVDVELFNEEADVLRLIETAHKNNVKVVMSNHDFDKTPAKEEIVSRLTRMEALGADLPKIAVMPKSAGDVLTLLDATNTVFEKANQPIITMSMAGTGVISRLAGEVFGSAMTFGAAKKASAPGQIDVNELRHVLDLLHKQF
Atome Classification :
(45 SA)
.........10........20........30........40-----........50........60........70........80........90........100.......110.......120..-----.....130.......140.......150.......160.......170.......180.......190.-.-.....200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
K
V
V
V
K
NVTFGEGAP
K
I
C
V
P
MV
G
K
T
V
A
A
L
K
E
E
A
E
M
L
Q
T
ID-----
L
D
V
V
E
W
R
V
D
F
F
E
D
V
K
D
L
A
K
V
E
A
A
L
G
E
I
R
A
ILPET
P
I
L
F
T
F
RSAKEGG
E
L
A
VS
D
E
F
Y
F
E
L
N
E
TLAGTG
K
I
D
L
V
D
V
E
LFNE
E
A
D
V
-----
L
R
L
I
E
T
AHKN
N
V
K
V
V
MSNHDFDKTP
A
K
E
E
I
V
S
R
L
T
R
M
E
A
LGADL
P
K
I
A
V
MPKSAG
D
V
L
T
L
LDA
T
N
T
V
F
E-K-ANQ
P
I
I
T
M
SMA
G
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
MTFGAAKKASAPGQI
D
V
N
E
L
R
H
V
L
D
L
L
H
KQF
21
PsiBlast_CBE
98.11
58%
-104
- C6 -
4H3D
3
AROD_PEPD6
D:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
--
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
23
PsiBlast_CBE
97.53
58%
-103
- C6 -
4H3D
3
AROD_PEPD6
B:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
1
PsiBlast_PDB
97.44
58%
-101
- C6 -
3JS3
1
AROD_PEPD6
A:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
2
PsiBlast_PDB
97.41
58%
-102
- C6 -
4H3D
3
AROD_PEPD6
A:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
25
PsiBlast_CBE
97.24
58%
-102
- C6 -
3JS3
1
AROD_PEPD6
C:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
24
PsiBlast_CBE
97.19
58%
-100
- C6 -
3JS3
1
AROD_PEPD6
D:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
22
PsiBlast_CBE
97.15
58%
-102
- C6 -
4H3D
2
AROD_PEPD6
C:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
---
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
29
PsiBlast_CBE
95.82
56%
-101
- C6 -
4GFS
5
AROD_SALTY
B:
[4-254]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
---
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
43
PsiBlast_CBE
95.78
55%
-97
- C6 -
1QFE
1
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
26
PsiBlast_CBE
95.65
58%
-98
- C6 -
3JS3
1
AROD_PEPD6
B:
[7-256]
--
K
V
Q
V
K
N
I
T
I
G
E
G
R
P
K
I
C
V
P
I
I
G
K
N
K
K
D
I
I
K
E
A
K
E
L
K
D
A
C
-----
L
D
I
I
E
W
R
V
D
F
F
E
N
V
E
N
I
K
E
V
K
E
V
L
Y
E
L
R
S
Y
I
H
D
I
P
L
L
F
T
F
R
S
V
V
E
G
G
E
K
L
I
S
R
D
Y
Y
T
T
L
N
K
E
I
S
N
T
G
L
V
D
L
I
D
V
E
L
F
M
G
D
E
V
I
-----
D
E
V
V
N
F
A
H
K
K
E
V
K
V
I
I
S
N
H
D
F
N
K
T
P
K
K
E
E
I
V
S
R
L
C
R
M
Q
E
L
G
A
D
L
P
K
I
A
V
M
P
Q
N
E
K
D
V
L
V
L
L
E
A
T
N
E
M
F
K
I
Y
-
A
D
R
P
I
I
T
M
S
M
S
G
M
G
V
I
S
R
L
C
G
E
I
F
G
S
A
L
T
F
G
A
A
K
S
V
S
A
P
G
Q
I
S
F
K
E
L
N
S
V
L
N
L
L
H
K
S
-
45
PsiBlast_CBE
95.54
55%
-92
- C6 -
1L9W
1
AROD_SALTI
C:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
37
PsiBlast_CBE
95.47
56%
-96
- C6 -
3M7W
4
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
85
Fugue
95.46
54%
-97
* C6 *
1QFE
1
AROD_SALTI
A:
[1-252]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
N
A
-
14
PsiBlast_PDB
95.27
55%
-97
- C6 -
1QFE
1
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
44
PsiBlast_CBE
95.16
55%
-93
- C6 -
1L9W
1
AROD_SALTI
D:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
32
PsiBlast_CBE
95.14
56%
-98
- C6 -
3OEX
1
AROD_SALTY
B:
[4-254]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
15
PsiBlast_PDB
95.12
55%
-95
- C6 -
1L9W
1
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
17
PsiBlast_PDB
95.04
55%
-96
- C6 -
3NNT
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
31
PsiBlast_CBE
95.00
56%
-97
- C6 -
3OEX
1
AROD_SALTY
C:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
35
PsiBlast_CBE
94.89
56%
-97
- C6 -
3M7W
4
AROD_SALTY
D:
[4-254]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
6
PsiBlast_PDB
94.70
56%
-98
- C6 -
4GUI
3
AROD_SALTY
A:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
51
PsiBlast_CBE
94.68
54%
-98
- C6 -
4CNP
5
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
46
PsiBlast_CBE
94.63
55%
-97
- C6 -
1L9W
1
AROD_SALTI
B:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
S
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
52
PsiBlast_CBE
94.48
54%
-96
- C6 -
4CNP
5
AROD_SALTI
A:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
7
PsiBlast_PDB
94.43
56%
-96
- C6 -
4GUJ
2
AROD_SALTY
A:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
50
PsiBlast_CBE
94.29
54%
-97
- C6 -
4UIO
5
?
A:
[3-250]
--
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
20
PsiBlast_PDB
94.28
54%
-98
- C6 -
4CNO
1
AROD_SALTI
A:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
58
PsiBlast_CBE
94.14
54%
-97
- C6 -
4CLM
1
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
Q
A
S
A
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
27
PsiBlast_CBE
94.08
56%
-98
- C6 -
4GUJ
3
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
55
PsiBlast_CBE
93.67
54%
-99
- C6 -
4CNO
1
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
9
PsiBlast_PDB
93.65
56%
-95
- C6 -
3LB0
2
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
56
PsiBlast_CBE
93.64
54%
-100
- C6 -
4CNN
4
AROD_SALTI
B:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
54
PsiBlast_CBE
93.64
54%
-98
- C6 -
4CNO
1
AROD_SALTI
C:
[1-250]
M
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
28
PsiBlast_CBE
93.63
56%
-94
- C6 -
4GUI
5
AROD_SALTY
B:
[5-254]
-
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
48
PsiBlast_CBE
93.62
55%
-98
- C6 -
3NNT
1
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
38
PsiBlast_CBE
93.47
56%
-96
- C6 -
3S42
6
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
13
PsiBlast_PDB
93.36
55%
-97
- C6 -
4GUH
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
53
PsiBlast_CBE
93.22
54%
-94
- C6 -
4CNO
1
AROD_SALTI
D:
[2-250]
-
K
T
V
T
V
K
N
L
I
I
G
E
G
M
P
K
I
I
V
S
L
M
G
R
D
I
N
S
V
K
A
E
A
L
A
Y
R
E
A
T
-----
F
D
I
L
E
W
R
V
D
H
F
M
D
I
A
S
T
Q
S
V
L
T
A
A
R
V
I
R
D
A
M
P
D
I
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
T
I
T
T
Q
H
Y
L
T
L
N
R
A
A
I
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
A
D
V
-----
K
A
T
V
D
Y
A
H
A
H
N
V
Y
V
V
M
S
N
H
D
F
H
Q
T
P
S
A
E
E
M
V
L
R
L
R
K
M
Q
A
L
G
A
D
I
P
K
I
A
V
M
P
Q
S
K
H
D
V
L
T
L
L
T
A
T
L
E
M
Q
Q
-
H
Y
A
D
R
P
V
I
T
M
S
M
A
K
E
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
A
V
N
D
L
R
S
V
L
M
I
L
H
---
40
PsiBlast_CBE
92.73
55%
-93
- C6 -
4GUH
2
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
47
PsiBlast_CBE
92.52
55%
-95
- C6 -
4IUO
1
AROD_SALTY
B:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
12
PsiBlast_PDB
92.49
55%
-101
- C6 -
4GUG
2
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
A
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
----
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
18
PsiBlast_PDB
92.45
55%
-94
- C6 -
4IUO
1
AROD_SALTY
A:
[25-275]
M
K
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
K
E
G
G
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
M
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
41
PsiBlast_CBE
91.50
55%
-103
- C6 -
4GUG
1
AROD_SALTY
B:
[27-275]
--
T
V
T
V
R
D
L
V
V
G
E
G
A
P
K
I
I
V
S
L
M
G
K
T
I
T
D
V
K
S
E
A
L
A
Y
R
E
A
D
-----
F
D
I
L
E
W
R
V
D
H
F
A
N
V
T
T
A
E
S
V
L
E
A
A
G
A
I
R
E
I
I
T
D
K
P
L
L
F
T
F
R
S
A
----
E
Q
A
L
T
T
G
Q
Y
I
D
L
N
R
A
A
V
D
S
G
L
V
D
M
I
D
L
E
L
F
T
G
D
D
E
V
-----
K
A
T
V
G
Y
A
H
Q
H
N
V
A
V
I
M
S
N
H
D
F
H
K
T
P
A
A
E
E
I
V
Q
R
L
R
K
M
Q
E
L
G
A
D
I
P
K
I
A
V
M
P
Q
T
K
A
D
V
L
T
L
L
T
A
T
V
E
M
Q
E
-
R
Y
A
D
R
P
I
I
T
M
S
M
S
K
T
G
V
I
S
R
L
A
G
E
V
F
G
S
A
A
T
F
G
A
V
K
K
A
S
A
P
G
Q
I
S
V
A
D
L
R
T
V
L
T
I
L
H
Q
--
61
PsiBlast_CBE
76.81
31%
-83
- C6 -
1SFJ
1
AROD_STAAR
A:
[4-232]
-------------------
V
E
V
V
A
T
I
T
P
Q
----
E
T
L
I
Q
K
I
N
H
R
I
DA
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
T
-
V
D
Q
V
A
E
M
I
T
K
L
-----
S
F
K
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
W
---
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
M
S
T
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
----------
60
PsiBlast_CBE
76.52
31%
-85
- C6 -
1SFJ
1
AROD_STAAR
B:
[4-232]
-------------------
V
E
V
V
A
T
I
T
P
Q
L
Y
--
E
T
L
I
Q
K
I
N
H
R
I
DA
I
D
V
L
E
L
R
I
D
Q
F
E
N
V
T
-
V
D
Q
V
A
E
M
I
T
K
L
---
Q
D
S
F
K
L
L
V
T
Y
R
T
K
L
Q
G
G
Y
G
Q
F
T
N
D
S
Y
L
N
L
I
S
D
L
A
N
I
N
G
I
D
M
I
D
I
E
W
---
Q
A
D
I
D
I
E
K
H
Q
R
I
I
T
H
L
Q
Q
Y
N
K
E
V
I
I
S
H
H
N
F
E
S
T
P
P
L
D
E
L
Q
F
I
F
F
K
M
Q
K
F
N
P
E
Y
V
K
L
A
V
M
P
H
N
K
N
D
V
L
N
L
L
Q
A
M
S
T
F
S
D
-
T
-
M
D
C
K
V
V
G
I
S
M
S
K
L
G
L
I
S
R
T
A
Q
G
V
F
G
G
A
L
T
Y
G
C
I
G
E
P
Q
A
P
G
Q
I
D
V
T
D
L
K
----------