@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1593: (2016-03-26 )
MIYFDNSATTKPNAAVLETYTKVASNYFANPSSLHRFGAKSKELLDASRKQIAAMMSALPEEIIFTSGGTEGNNLAIKGLVYSYQNRGKHIITSSIEHPSVRVVMEELEQEGFTVKYLPVDKNGVIKLEELKAALTDETILVSIMGVNNEVGSIQPLQEIGEMLSVLENTFFHVDFVQAIGKIPLTLDANSIDLLTFSGHKFHALRGTGILFKRKNVHLHPEILGGGQEMGYRSGTENLAGNVALAKALRLTLENEPRKEALIEIRDYLLTKIAQMSDMTVHTKQSVAAPHIVCFSAKGHRGEILVHALEKEDIYISTTSACSSKQKLASSTLKAMGVTDEEATGAVRVSLSYENRLSEAKIFIQKLQEIIENLNKVVK
Atome Classification :
(26 SA)
-.........10........20....--....30...-.....40........50........60........70........80-...-------.----...----.90--.........100......-.110........120-.......130....--...140.......150.......160..---------...---------..---------170.......180.......190.......200.......210..---.-------...-------.220...---....230.......240.......250.-..-...-..-260...-.....270.-..-....280-..----.....----290.......300.--........310.......320-....-.-..330.......340.......350.......360.......370.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
I
YFDNSATTKP
N
A
A
V
L
E
T
Y
T
K
V
A
S
--NYFA
N
P
S
S
L
-
H
R
FGA
K
S
K
E
L
L
D
A
S
R
K
Q
I
A
A
M
M
S
AL
P
E
E
I
I
F
TSGGTEGN
N
L
A
I
K
G
L
V
-
Y
SY-------Q----NRG----
K
H
---
I
I
TSSIEH
P
S
V
R
V
V
M
E
E
L
-
E
Q-EG
F
T
V
K
Y
L
PVDK-N
G
V
I
K
L
E
E
L
K
A
ALT--D
E
T
I
L
V
S
I
M
GVNNEVGS
I
Q
P
L
Q
E
I
G
E
M
L
---------
S
V
L
---------
E
N
---------TF
F
H
V
D
F
V
Q
A
IGKI
P
L
T
L
DAN
S
I
D
L
L
T
FSG
H
K
F
H
A
L
RG
T
G
I
L
F
K
R---K-------N
V
H
-------LH
P
E
ILG---GGQEMGYRSGTENLA
G
N
V
A
L
A
K
A
L
R
L
-T-LE-NEP-
R
K
-
E
A
-
L
I
E
-
I
R
D
Y
L
L
T
K
I
-
A
Q-MSD
M
T
V
H-TK----QSVAA----
P
H
I
V
C
F
SAKGH--R--
G
E
I
L
V
H
A
LEKE
D
I
Y
I
STTSAC-
S
S
K
Q
-
K
-
L
A
S
S
T
L
K
AMGVTDEEAT
G
A
V
R
V
S
L
SYENR
L
S
E
A
K
I
F
I
Q
K
L
Q
E
I
I
E
N
L
N
K
VVK-
35
HHSearch
96.14
39%
-95
- C1 -
1EG5
3
?
A:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
-
E
T
F
------------
E
K
R
K---
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
---------
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
V
P
-------
I
R
P
L
I
H
G
---
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
-
V
E
-
E
L
S
E
A
A
-
K
H
-
M
E
K
-
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
H
I
I
-
T
P
----
L
E
I
S
L
----
P
N
T
L
S
V
S
F
P
N
I
--
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
59
Fugue
93.40
38%
-98
* C1 *
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
-
E
T
F
-------
E
----
K
R
K
----
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
---------
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
V
P
-------
I
R
P
L
I
H
G
---
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
-
V
E
E
L
S
E
-
A
A
-
K
H
-
M
E
K
-
L
R
S
K
L
V
S
G
L
-
M
N
-
L
-
G
A
H
I
I
-
T
P
----
L
E
I
S
L
----
P
N
T
L
S
V
S
F
P
N
I
--
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
---------------
T
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
4
PsiBlast_PDB
93.00
38%
-92
- C1 -
1EG5
3
?
A:
[3-376]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
-
E
T
F
-------
E
----
K
R
K
----
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
---------
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
V
P
-------
I
R
P
L
I
H
G
---
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
-
V
E
-
E
L
S
-
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
-
M
N
-
L
G
A
H
I
I
--
T
P
----
L
E
I
S
L
----
P
N
T
L
S
V
S
F
P
N
I
--
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
21
PsiBlast_CBE
91.41
38%
-91
- C1 -
1ECX
2
?
B:
[3-376]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
-
E
T
F
-------
E
----
K
R
K
----
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
---------
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
V
P
-------
I
R
P
L
I
H
G
---
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
-
V
E
-
E
L
S
-
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
-
M
N
-
L
G
A
H
I
I
--
T
P
----
L
E
I
S
L
----
P
N
T
L
S
V
S
F
P
N
I
--
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
1
PsiBlast_PDB
90.80
38%
-95
- C1 -
1ECX
2
?
A:
[3-376]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
-
E
T
F
-------
E
----
K
R
K
----
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N--------
K
E
---------
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
---
K
-------
G
V
P
-------
I
R
P
L
I
H
G
---
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
-
A
-
V
E
-
E
L
S
-
E
A
-
A
K
-
H
M
E
K
L
R
S
K
L
V
S
G
L
-
M
N
-
L
G
A
H
I
I
--
T
P
----
L
E
I
S
L
----
P
N
T
L
S
V
S
F
P
N
I
--
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
---------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
2
PsiBlast_PDB
89.92
41%
-82
- C1 -
3LVJ
2
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
-
N
F
Y
-------
Q
----
K
K
G
----
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
----------
R
G
---------
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
KP-----
R
V
R
-------
I
E
A
Q
M
H
G
---
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
-
K
E
-
E
M
A
-
T
E
M
E
R
-
L
R
G
-
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
Y
L
N
-
G
D
----
L
E
H
G
A
----
P
N
I
L
N
V
S
F
N
Y
V
--
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
-------
S
-
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
-----------------------------
3
PsiBlast_PDB
89.74
41%
-83
- C1 -
3LVK
1
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
-
N
F
Y
-------
Q
----
K
K
G
----
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
----------
R
G
---------
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
KP-----
R
V
R
-------
I
E
A
Q
M
H
G
---
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
-
K
E
-
E
M
A
-
T
E
M
E
R
-
L
R
G
-
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
Y
L
N
-
G
D
----
L
E
H
G
A
----
P
N
I
L
N
V
S
F
N
Y
V
--
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
------
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
-----------------------------
22
PsiBlast_CBE
89.64
41%
-83
- C1 -
3LVJ
2
ISCS_ECO57
B:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
-
N
F
Y
-------
Q
----
K
K
G
----
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
-
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
----------
R
G
---------
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
---
R
KP-----
R
V
R
-------
I
E
A
Q
M
H
G
---
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
-
A
-
K
E
-
E
M
A
-
T
E
M
E
R
-
L
R
G
-
L
R
N
R
L
W
N
G
I
-
K
D
-
I
E
E
V
Y
L
N
-
G
D
----
L
E
H
G
A
----
P
N
I
L
N
V
S
F
N
Y
V
--
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
------
L
-
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
-----------------------------
7
PsiBlast_PDB
89.32
34%
-86
- C1 -
4HVK
12
ISCS2_ARCFU
A:
[2-373]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
-
M
R
N
-------
A
----
R
K
G
----
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
-----------
G
K
---------
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
A
K
-------
L
Q
P
V
I
L
G
---
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
-
W
R
E
-
E
A
-
E
R
-
L
R
R
-
L
R
D
R
I
I
D
N
V
-
L
K
-
I
E
E
S
Y
L
N
-
G
H
----
P
E
K
R
L
----
P
N
N
V
N
V
R
F
S
Y
I
--
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
-----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
61
Fugue
88.47
32%
-89
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
I
-
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
Y
-
W
A
R
-------
R
----
D
A
E
----
P
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
-
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
E
F
----------
G
---------
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
---
R
-------
D
V
T
-------
C
V
P
L
M
H
G
---
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
-
A
-
V
D
G
L
E
E
-
N
S
-
A
R
-
L
R
L
-
L
R
D
R
L
V
E
G
V
-
L
A
E
I
D
D
V
C
L
N
G
A
D
----
D
P
M
R
L
----
A
G
N
A
H
F
T
F
R
G
C
--
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
P
-----------
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
23
PsiBlast_CBE
87.88
34%
-84
- C1 -
4EB7
4
ISCS2_ARCFU
B:
[2-373]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
-
M
R
N
-------
A
----
R
K
G
----
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
-----------
G
K
---------
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
A
K
-------
L
Q
P
V
I
L
G
---
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
-
W
R
E
-
E
A
-
E
R
-
L
R
R
-
L
R
D
R
I
I
D
N
V
-
L
K
-
I
E
E
S
Y
L
N
-
G
H
----
P
E
K
R
L
----
P
N
N
V
N
V
R
F
S
Y
I
--
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
6
PsiBlast_PDB
87.86
34%
-82
- C1 -
4EB7
7
ISCS2_ARCFU
A:
[2-373]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
-
M
R
N
-------
A
----
R
K
G
----
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
-----------
G
K
---------
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
A
K
-------
L
Q
P
V
I
L
G
---
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
-
W
R
E
-
E
A
-
E
R
-
L
R
R
-
L
R
D
R
I
I
D
N
V
-
L
K
-
I
E
E
S
Y
L
N
-
G
H
----
P
E
K
R
L
----
P
N
N
V
N
V
R
F
S
Y
I
--
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
-
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
24
PsiBlast_CBE
87.51
34%
-85
- C1 -
4EB5
5
ISCS2_ARCFU
B:
[2-373]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
-
M
R
N
-------
A
----
R
K
G
----
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
-----------
G
K
---------
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
A
K
-------
L
Q
P
V
I
L
G
---
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
-
W
R
E
-
E
A
-
E
R
-
L
R
R
-
L
R
D
R
I
I
D
N
V
-
L
K
-
I
E
E
S
Y
L
N
-
G
H
----
P
E
K
R
L
----
P
N
N
V
N
V
R
F
S
Y
I
--
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
5
PsiBlast_PDB
87.08
34%
-82
- C1 -
4EB5
6
ISCS2_ARCFU
A:
[2-373]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
-
M
R
N
-------
A
----
R
K
G
----
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
-----------
G
K
---------
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
---
K
-------
E
A
K
-------
L
Q
P
V
I
L
G
---
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
-
T
A
M
E
-
W
R
E
-
E
A
-
E
R
-
L
R
R
-
L
R
D
R
I
I
D
N
V
-
L
K
-
I
E
E
S
Y
L
N
-
G
H
----
P
E
K
R
L
----
P
N
N
V
N
V
R
F
S
Y
I
--
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
-
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
11
PsiBlast_PDB
83.80
31%
-71
- C1 -
3GZC
2
SCLY_HUMAN
A:
[27-436]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
--
E
A
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
V
-
K
H
F
-------
H
A
N
Q
T---G
A
K
-
P
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
-
Q
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
---------
K
A
L
---------
N
Q
E
R
V
A
A
G
L
P
P
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG
E
-------
F
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
-
V
-
T
Q
-
N
C
E
-
A
Y
-
E
A
H
M
R
D
-
V
R
D
Y
L
E
E
R
L
E
A
E
-
F
G
Q
K
R
I
H
-
L
N
----
S
Q
F
P
G
TQRL
P
N
T
C
N
F
S
I
R
G
P
--
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
-
H
S
D
H
G
D
-
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
------
30
PsiBlast_CBE
83.49
31%
-74
- C1 -
3GZD
3
SCLY_HUMAN
B:
[27-436]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
--
E
A
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
V
-
K
H
F
-------
H
ANQT
S
--GAK-
P
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
-
Q
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
---------
K
A
L
---------
N
Q
ERVAAGLPP
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG
E
-------
F
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
-
V
-
T
Q
-
N
C
E
-
A
Y
-
E
A
H
M
R
D
-
V
R
D
Y
L
E
E
R
L
E
A
E
-
F
G
Q
K
R
I
H
-
L
N
----
S
Q
F
P
G
TQRL
P
N
T
C
N
F
S
I
R
G
P
--
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
-----------
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
------
41
HHSearch
83.10
33%
-70
- C1 -
3A9Z
5
SCLY_RAT
A:
[19-431]
-
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q
Q
T
L
Q------
T
R
----
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
---------
K
A
L
N
Q
I
R
A
A
S
GL
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
---
G
-------
V
G
K
-------
L
T
P
L
Y
P
M
LFG
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
T
Y
E
-
A
H
-
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
SRFP
G
V
E
R
L
----
P
N
T
C
N
F
S
I
Q
G
S
--
Q
LR
G
Y
M
V
L
A
Q
--
C
Q
T
L
L
A
S
V
G
A
S
C
-
H
S
D
H
-
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
---
28
PsiBlast_CBE
82.67
32%
-70
- C1 -
3A9X
5
SCLY_RAT
B:
[20-429]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q
Q
T
L
-
Q
-------T
R
--
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
GVG
K
-------
L
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
-
T
Y
-
E
A
H
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
----
S
R
F
P
G
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
QL
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
-----
10
PsiBlast_PDB
82.57
32%
-72
- C1 -
3A9Z
5
SCLY_RAT
A:
[20-432]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q
Q
T
L
-
Q
-------T
R
--
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
GVG
K
-------
L
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
-
T
Y
-
E
A
H
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
----
S
R
F
P
G
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
QL
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
12
PsiBlast_PDB
82.35
31%
-72
- C1 -
3GZD
3
SCLY_HUMAN
C:
[27-436]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
M
T
K
A
M
W
--
E
A
W
G
N
P
S
S
P
-
Y
S
A
G
R
K
A
K
D
I
I
N
A
A
R
E
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
V
V
-
K
H
F
-------
H
ANQT
S
--GAK-
P
H
---
F
I
T
S
S
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
E
-
Q
V
A
A
V
T
F
V
P
V
S
K
V
S
G
Q
T
E
V
D
D
I
L
A
A
V
R
--
P
T
T
R
L
V
T
I
M
L
A
N
N
E
T
G
I
V
M
P
V
P
E
I
S
Q
R
I
---------
K
A
L
---------
N
Q
ERVAAGLPP
I
L
V
H
T
D
A
A
Q
A
L
G
K
Q
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
I
R
GLG
E
-------
F
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
E
L
-
V
-
T
Q
-
N
C
E
-
A
Y
-
E
A
H
M
R
D
-
V
R
D
Y
L
E
E
R
L
E
A
E
-
F
G
Q
K
R
I
H
-
L
N
----
S
Q
F
P
G
TQRL
P
N
T
C
N
F
S
I
R
G
P
--
R
--
L
Q
G
H
V
V
L
A
Q
C
R
V
L
M
A
S
V
G
A
A
C
------
D
-
Q
P
S
P
V
L
L
S
Y
G
V
P
F
D
V
A
R
N
A
L
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
V
V
Q
D
L
K
Q
A
V
A
Q
L
------
27
PsiBlast_CBE
81.47
32%
-72
- C1 -
3A9Y
4
SCLY_RAT
B:
[20-432]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q
Q-----------T
R
--
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
GVG
K
-------
L
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
-
T
Y
-
E
A
H
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
----
S
R
F
P
G
VERL
P
N
T
C
N
F
S
I
Q
G
S
QL
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
25
PsiBlast_CBE
81.40
35%
-84
- C1 -
3VAX
2
?
B:
[22-377]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
G
E
-------
R
----
T
G
R
----
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
-
R
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
---------
P
----------
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
REEMDDE
R
V
P
-------
L
E
P
I
M
F
G
---
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
-
A
E
-
H
A
Q
-
W
Q
-
V
A
-
A
Q
D
-
L
R
S
R
L
L
A
G
L
-
A
S
-
T
S
-
F
Q
V
N
-
G
D
----
Q
D
H
V
V
----
P
H
I
L
N
L
S
F
E
D
V
--
D
--
A
E
A
F
L
V
T
L
-
K
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
----------------------------
26
PsiBlast_CBE
81.19
32%
-72
- C1 -
3A9Z
3
SCLY_RAT
B:
[20-432]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q------------T
R
--
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
GVG
K
-------
L
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
-
T
Y
-
E
A
H
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
----
S
R
F
P
G
VERL
P
N
T
C
N
F
S
I
Q
G
S
QL
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
-
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--
8
PsiBlast_PDB
81.19
35%
-85
- C1 -
3VAX
1
?
A:
[22-377]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
G
E
-------
R
----
T
G
R
----
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
-
R
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
---------
P
----------
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
R
EEMDDE
R
V
P
-------
L
E
P
I
M
F
G
---
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
-
A
E
-
H
A
Q
-
W
Q
-
V
A
-
A
Q
D
-
L
R
S
R
L
L
A
G
L
-
A
S
-
T
S
-
F
Q
V
N
-
G
D
----
Q
D
H
V
V
----
P
H
I
L
N
L
S
F
E
D
V
--
D
--
A
E
A
F
L
V
T
L
-
K
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
----------------------------
38
HHSearch
81.04
34%
-84
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
-
P
Y
G
-------
E
----
R
T
G
R---
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
-
R
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
T
----------
P
---------
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
---
R
-------
R
E
E
MDDERVP
L
E
P
I
M
F
G
---
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
-
F
-
E
A
-
E
H
A
Q
W
Q
-
V
A
-
A
Q
D
-
L
R
S
R
L
L
A
G
L
-
A
S
-
T
-
S
F
Q
V
N
-
G
D
----
Q
D
H
V
V
----
P
H
I
L
N
L
S
F
E
D
V
--
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
-
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
9
PsiBlast_PDB
80.94
32%
-76
- C1 -
3A9X
3
SCLY_RAT
A:
[20-432]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
-
R
C
F
H
E
Q
Q
T
L
-
Q
----
G
--EG
T
R
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
---------
P
R
---------
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
GVG
K
-------
L
T
P
-------
L
Y
P
M
L
F
G
---
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
-
V
-
S
E
-
N
C
E
-
T
Y
-
E
A
H
M
R
D
-
I
R
D
Y
L
E
E
R
L
-
E
A
-
E
F
G
K
R
I
H
-
L
N
----
S
R
F
P
G
VERL
P
N
T
C
N
F
S
I
Q
G
S
QL
R
--
G
Y
M
V
L
--
A
Q
C
Q
T
L
L
A
S
V
G
A
---------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
P
V
--