@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2573: (2016-04-05 )
MKAVGLTKASTDFVDIEIDKPVPENHDLLVKIKAISINPVDTKQREAAKLSGEEVRILGWDAVGEVVDTGSEVTLFQTGQDVYFAGDVTRPGVYAEYTLIDERLVGLKPHNLNVEEAAAMPLTTITAWEALFDRLTITENDKGKSILIINGAGGVGSIATQLAANTGLEVIATASRSETVEWTKSHGANYVINHRENIPEQLEELGFKKGVDFILCLHNTSAHWDEMQEAIRPQGKICSIVELTEPVEMTLLKDKSATFSYEFMFTRSKYDTADKIRQHEILTEAAHMLDKGNLTTTLNQVLSPVNAATIEEAHKIISSGKMIGKLVVKGFE
Atome Classification :
(20 SA)
.........-----10--------------.-----.---..-.-....20...--.--....30........40....--..--.-------------.50-------.-........60........70...-.....80......---------------------------------------------.----------------------------------------.------------------------90........100-.-......110.......120---.......130.--...-.------..140-...--......150.......160.-...-.-.-.-170.......180.......190..-.----..------------------..200....-...210.......220.-.......230.-......240....----.---.---.--------250..-......-.-260.......270--.......280.......290...--..-.-.--------300-.........310.......320----........330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKAVGLTKA-----S---------------T-----
D
---
F
V
-
D
-
I
E
IDKPVPE--N--H
D
L
L
V
K
I
K
A
I
S
INPVD
T
K
Q
R
--
E
A
--
A
-------------KL--------S-G
E
E
V
R
I
L
G
W
D
A
V
G
E
V
VDTGS
E
V
T
-
L
F
QTG
Q
D
V
Y
F
AGD---------------------------------------------V----------------------------------------T------------------------RPG
V
Y
A
E
Y
T
L
I
D
E
-R-LVGLKPHNL
N
V
E
E
AAAMP
L
---
T
T
I
T
A
W
E
A
L
F
D
--R
L
T
-I------TEN---DKG--
K
S
I
L
I
I
NGAG
G
V
G
S
I
A
T
Q
L
A
-ANT-G-
L
-
E
-
V
I
A
TASRS
E
T
V
E
W
T
K
SHGA
N
Y
V
I
NH-R----EN------------------
I
P
E
Q
L
E
ELG-FKKGV
D
F
I
L
C
LHNTS-A-
H
W
D
E
M
Q
E
A
IRP-QG
K
I
C
S
I
V
ELTEP----
V
---
E
---
M
--------
T
--
L
L-KDKSA
T
-
F
-
S
Y
E
F
M
F
TRSKYD
T
--
A
D
K
I
R
Q
H
E
I
L
T
E
A
A
H
M
LDKGN
L
T
--
T
T
-
L
-
N
--------
Q
---
V
LSPV
N
A
A
T
I
E
E
A
H
K
I
I
S
SG-
K
----
M
I
G
K
L
V
VKGFE
21
PsiBlast_CBE
98.17
43%
-89
- C1 -
3FBG
1
?
B:
[3-335]
L
K
A
I
G
F
E
Q
P
F
K
LSD
G
---------------
N
-----
L
---
F
K
-
T
-
F
N
L
D
I
P
E
P
K
--
V
--
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
V
--
S
-----------------------
P
-----
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
Y
S
G
S
---------------------------------------------
P
----------------------------------------
D
------------------------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
--
V
F
G
-
I
------
S
R
N
RNE
N
E
G
--
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
-
K
A
Y
-
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
-
K
----
E
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
L
-
V
D
Y
V
F
C
T
F
N
T
D
-
M
-
Y
Y
D
D
M
I
Q
L
V
K
P
-
R
G
H
I
A
T
I
V
A
F
E
N
D
----
Q
---
D
---
L
--------
N
--
A
L
-
K
P
K
S
L
S
-
F
-
S
H
E
F
M
F
A
R
P
L
N
Q
T
--
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
-
T
-
T
--------
K
---
V
I
E
G
L
T
T
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
------
M
I
G
K
L
V
I
----
45
HHSearch
96.92
45%
-86
- C1 -
3FBG
1
?
A:
[3-337]
L
K
A
I
G
F
E
Q
P
-----
F
---------------
K
LSDGN
L
---
F
K
T
F
-
N
-
L
D
I
P
E
P
K
--
V
--
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
--
L
M
--
D
-------------
V
S
-----------
K
A
P
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
Y
S
G
S
---------------------------------------------
P
----------------------------------------
D
------------------------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
--
V
F
G
-
I
SRNRNE
N
------
E
G
--
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
-
K
A
Y
-
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
-
K
----
E
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
-
L
V
D
Y
V
F
C
T
-
F
N
T
-
D
M
Y
Y
D
D
M
I
Q
L
V
K
P
-
R
G
H
I
A
T
I
V
A
F
E
N
D
----
Q
---
D
---
L
--------
N
--
A
L
-
K
P
K
S
L
S
-
F
-
S
H
E
F
M
F
A
R
P
L
N
Q
T
--
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
-
T
-
T
--------
K
V
I
E
G
L
-
T
T
--
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
-
T
----
M
I
G
K
L
V
I
N
L
--
2
PsiBlast_PDB
96.01
43%
-86
- C1 -
3FBG
1
?
A:
[3-335]
L
K
A
I
G
F
E
Q
P
F
K
LSD
G
---------------
N
-----
L
---
F
K
-
T
-
F
N
L
D
I
P
E
P
K
--
V
--
H
E
I
L
V
K
I
Q
S
I
S
V
N
P
V
D
T
K
Q
R
L
M
D
V
--
S
-------------
K
A
--------
P
-----
R
V
L
G
F
D
A
I
G
V
V
E
S
V
G
N
E
V
T
-
M
F
N
Q
G
D
I
V
Y
Y
S
G
S
---------------------------------------------
P
----------------------------------------
D
------------------------
Q
N
G
S
N
A
E
Y
Q
L
I
N
E
-
R
-
L
V
A
K
A
P
K
N
I
S
A
E
Q
A
V
S
L
P
L
---
T
G
I
T
A
Y
E
T
L
F
D
--
V
F
G
-
I
------
S
R
N
RNE
N
E
G
--
K
T
L
L
I
I
N
G
A
G
G
V
G
S
I
A
T
Q
I
A
-
K
A
Y
-
G
-
L
-
R
-
V
I
T
T
A
S
R
N
E
T
I
E
W
T
K
K
M
G
A
D
I
V
L
N
H
-
K
----
E
S
------------------
L
L
N
Q
F
K
T
Q
G
-
I
E
L
-
V
D
Y
V
F
C
T
F
N
T
D
-
M
-
Y
Y
D
D
M
I
Q
L
V
K
P
-
R
G
H
I
A
T
I
V
A
F
E
N
D
----
Q
---
D
---
L
--------
N
--
A
L
-
K
P
K
S
L
S
-
F
-
S
H
E
F
M
F
A
R
P
L
N
Q
T
--
D
D
M
I
K
H
H
E
Y
L
E
D
I
T
N
K
V
E
Q
N
I
Y
Q
--
P
T
-
T
-
T
--------
K
---
V
I
E
G
L
T
T
E
N
I
Y
Q
A
H
Q
I
L
E
S
N
-
T
----
M
I
G
K
L
V
I
----
1
PsiBlast_PDB
85.46
44%
-67
- C1 -
4DVJ
-
?
A:
[24-359]
-
K
A
V
G
Y
N
K
P
-----
A
P
I-------------
T
-----
D
DAS
L
L
-
D
-
I
E
L
P
K
P
A
P
A
--
G
--
H
D
I
L
V
E
V
K
A
V
S
V
N
P
V
D
Y
K
V
R
--
R
S
--
T
-------------
P
P
-----------
T
D
W
K
V
I
G
Y
D
A
A
G
I
V
S
A
V
G
P
D
V
T
-
L
F
R
P
G
D
E
V
F
Y
A
G
S
---------------------------------------------
I
----------------------------------------
I
------------------------
R
P
G
T
N
A
E
F
H
L
V
D
E
-
R
-
I
V
G
R
K
P
K
T
L
D
W
A
E
A
A
A
L
P
L
---
T
S
I
T
A
W
E
A
F
F
D
--
R
L
D
-
V
------
N
K
P
---
V
P
G
AA
P
A
I
L
I
V
G
G
A
G
G
V
G
S
I
A
V
Q
I
A
R
Q
R
T
-
D
-
L
-
T
-
V
I
A
T
A
S
R
P
E
T
Q
E
W
V
K
S
L
G
A
H
H
V
I
D
H
-
S
----
K
P
------------------
L
A
A
E
V
A
A
L
G
-
L
G
A
P
A
-
F
V
F
S
T
T
H
T
D
-
K
-
H
A
A
E
I
A
D
L
I
A
P
-
Q
G
R
F
C
-
L
I
D
D
P
S
A
----
F
---
D
---
I
--------
M
--
L
F
-
K
R
K
A
V
S
-
I
-
H
H
E
L
M
F
T
R
P
M
F
G
T
--
P
D
M
S
E
Q
G
R
L
L
N
D
V
S
R
L
V
D
E
G
R
L
R
--
T
T
-
L
-
T
--------
N
---
R
L
S
P
I
N
A
A
N
L
K
Q
A
H
A
L
V
E
S
G
-
T
----
A
R
G
K
V
V
I
E
G
F
-
35
HHSearch
73.81
24%
-82
- C1 -
3KRT
1
?
A:
[31-421]
Y
R
A
I
T
V
H
K
D
-----
E
TEMFAGLETRDKDPR
K
-----
S
---
I
H
L
D
-
D
-
V
P
V
P
E
L
G
--
P
--
G
E
A
L
V
A
V
M
A
S
S
V
N
Y
N
S
V
H
T
S
--
I
F
--
E
PLST
F
G
F
L
E
R
Y
G
R
V
S
DLAKR---
H
-
D
L
P
Y
H
V
I
G
S
D
L
A
G
V
V
L
R
T
G
P
G
V
N
-
A
W
Q
A
G
D
E
V
V
A
H
C
L
---------------------------------------------
S
VELESSDGHNDTMLDPEQRIWGFE----------------
T
------------------------
N
F
G
G
L
A
E
I
A
L
V
K
S
-
N
-
Q
L
M
P
K
P
D
H
L
S
W
E
E
A
A
A
P
G
L
---
V
N
S
T
A
Y
R
Q
L
V
S
RN
G
A
G
-
M
------
K
------
Q
G
--
D
N
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
T
Q
F
A
-
L
A
G
-
G
-
A
-
N
-
P
I
C
V
V
S
S
P
Q
K
A
E
I
C
R
A
M
G
A
E
A
I
I
D
R
-
N
----
A
E
GYRFWKDENTQD
P
K
E
W
K
R
F
G
K
R
I
R
E
L
T
G
G
E
-
D
I
D
I
V
F
E
H
-
P
G
R
-
E
-
T
F
G
A
S
V
F
V
T
R
K
-
G
G
T
I
T
T
C
A
S
T
S
G
Y
----
M
H
--
E
---
Y
D
N------
R
--
Y
L
-
W
M
S
L
K
R
-
I
-
I
--------------
G
S
H
F
A
N
Y
R
E
A
W
E
A
N
R
L
I
A
K
G
R
I
H
--
P
T
-
L
-
S
--------
K
---
V
Y
-
S
L
--
E
D
T
G
Q
A
A
Y
D
V
H
R
N
-
L
----
H
Q
G
K
V
G
V
L
C
--
37
HHSearch
72.08
27%
-82
- C1 -
2EIH
1
?
A:
[1-342]
M
R
A
V
V
M
R
A
R
GG---
P
---------------
E
-----
V
---
L
E
V
A
-
D
-
L
P
V
P
E
P
G
--
P
--
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
--
K
G
--
V
-------------
A
S
--------
P
K
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
-
G
F
A
P
G
D
E
V
V
I
N
P
G
---------------------------------------------
L
SCGRC
E
R
C
L
A
GEDNLCPRYQILGE----------------
H
------------------------
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
-
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
---
T
F
L
T
A
W
Q
M
V
V
D
--
K
L
G
-
V
------
R
------
P
G
--
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
-
K
L
F
-
G
-
A
-
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
-
T
----
H
P
D-----------------
W
P
K
E
V
R
R
L
T
G
G
K
-
G
A
D
K
V
V
D
H
-
T
G
A
-
L
-
Y
F
E
G
V
I
K
A
T
A
N
-
G
G
R
I
A
I
A
G
A
S
S
G
Y
----
E
---
G
T--
L
PF------
A
--
H
V
-
F
Y
R
Q
L
S
-
I
-
L
--------------
G
S
T
M
A
S
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
--
P
V
-
V
-
G
--------
Q
---
V
L
-
P
L
--
E
A
A
A
E
G
H
R
L
L
E
E
R
-
R
----
V
F
G
K
V
V
L
Q
V
--
41
HHSearch
71.72
25%
-75
- C1 -
2C0C
1
ZADH2_HUMAN
A:
[24-362]
M
Q
K
L
V
V
T
R
L
-----
S
---------------
P
N
F
R
E
-
A
---
V
T
-
L
S
R
D
C
P
V
P
L
P
G
--
D
--
G
D
L
L
V
R
N
R
F
V
G
V
N
A
S
D
I
N
Y
S
--
A
G
--
R
-------------
Y
D
P-------
S
-
V
K
P
P
F
D
I
G
F
E
G
I
G
E
V
V
A
L
G
L
S
A
S
A
R
Y
T
V
G
Q
A
V
A
Y
M
A
-----------------------------------------------------------------------------------------------------------------
P
G
S
F
A
E
Y
T
V
V
P
A
-
S
-
I
A
T
P
V
P
S
V
K
--
P
E
Y
L
T
L
L
V
---
S
G
T
T
A
Y
I
S
L
K
E
--
L
G
G
-
L
------
S
------
E
G
--
K
K
V
L
V
T
A
A
A
G
G
T
G
Q
F
A
M
Q
L
S
-
K
K
A
-
K
-
C
-
H
-
V
I
G
T
C
S
S
D
E
K
S
A
F
L
K
S
L
G
C
D
R
P
I
N
Y
-
K
----
T
E
P-----------------
V
G
T
V
L
K
Q
E
Y
-
P
E
-
G
V
D
V
V
Y
E
S
-
V
G
G
-
A
-
M
F
D
L
A
V
D
A
L
A
T
-
K
G
R
L
I
V
I
G
F
I
S
G
Y
----
Q
---
T
PTG
L
S
P
V
KAGT
L
P
A
-
K
L
-
L
K
K
S
A
S
-
V
-
Q
G
F
F
L
N
H
---------
Y
L
S
K
Y
Q
A
A
M
S
H
L
L
E
M
C
V
S
G
D
L
V
--
C
E
-
V
-
D
LGDLSPEG
R
---
F
T
-
G
L
--
E
S
I
F
R
A
V
N
Y
M
Y
M
G
-
K
----
N
T
G
K
I
V
V
E
L
P
H
44
HHSearch
69.81
30%
-67
- C1 -
3GAZ
1
?
A:
[8-336]
M
I
A
A
V
V
E
E
A
-----
N
---------------
G
-----
P
---
F
V
L
R
-
K
-
L
A
R
P
Q
P
A
--
P
--
G
Q
V
L
V
Q
I
E
A
S
G
T
N
P
L
D
A
K
I
R
--
A
G
--
E
-------------
A
P
HA------
Q
-
Q
P
L
P
A
I
L
G
M
D
L
A
G
T
V
V
A
V
G
P
E
V
D
-
S
F
R
V
G
D
A
V
F
G
L
T
G
---------------------------------------------
G
VG--------------------------------------
G
------------------------
L
Q
G
T
H
A
Q
F
A
A
V
D
A
-
R
-
L
L
A
S
K
P
A
A
L
T
M
R
Q
A
S
V
L
P
L
---
V
F
I
T
A
W
E
G
L
V
D
--
R
A
Q
-
V
------
Q
------
D
G
--
Q
T
V
L
I
Q
G
G
G
G
G
V
G
H
V
A
I
Q
I
A
-
L
A
R
-
G
-
A
-
R
-
V
F
A
T
A
R
G
-
S
D
L
E
Y
V
R
D
L
G
A
T
P
I
D
A
S
-
R
----
E
P
-------------------
E
D
Y
A
A
E
H
T
A
G
Q
-
G
F
D
L
V
Y
D
T
-
L
G
G
-
P
-
V
L
D
A
S
F
S
A
V
K
R
-
F
G
H
V
V
S
C
L
G
W
G
T
H
--------
K
---
L
--------
A
--
P
L
-
S
F
K
Q
A
T
-
Y
-
S
G
V
F
T
L
H
T
L
L
A
N
---
E
G
L
A
H
F
G
E
M
L
R
E
A
D
A
L
V
Q
T
G
K
L
A
--
P
R
-
L
D
P
--------
R
---
T
F
-
S
I
--
A
E
I
G
S
A
Y
D
A
V
L
G
R
-
N
DVPR
Q
R
G
K
I
A
I
T
V
E
-
32
HHSearch
69.25
24%
-79
- C1 -
1JVB
2
ADH_SULSO
A:
[1-347]
M
R
A
V
R
L
V
E
I
-----
G
---------------
K
-----
P
---
L
S
L
Q
-
E
-
I
G
V
P
K
P
K
--
G
--
P
Q
V
L
I
K
V
E
A
A
G
V
C
H
S
D
V
H
M
R
--
Q
G
--
R
-------------
F
G
NLRIVEDL
G
-
V
K
L
P
V
T
L
G
H
E
I
A
G
K
I
E
E
V
G
D
E
V
V
-
G
Y
S
K
G
D
L
V
A
V
N
P
W
---------------------------------------------
Q
GEGNC
Y
Y
C
R
I
GEEHLCDSPRWLGI----------------
N
------------------------
F
D
G
A
Y
A
E
Y
V
I
V
P
H
-
Y
-
K
Y
M
Y
K
L
R
R
L
N
A
V
E
A
A
P
L
T
C
---
S
G
I
T
T
Y
R
A
V
R
---
K
A
S
-
L
------
D
------
P
T
--
K
T
L
L
V
V
G
A
G
G
G
L
G
T
M
A
V
Q
I
A
-
K
A
V
-
S
G
A
-
T
-
I
I
G
V
D
V
R
E
E
A
V
E
A
A
K
R
A
G
A
D
Y
V
I
N
A
-
S
----
M
Q
D-----------------
P
L
A
E
I
R
R
I
T
E
S
K
-
G
V
D
A
V
I
D
L
-
N
N
S
E
K
-
T
L
S
V
Y
P
K
A
L
A
K
-
Q
G
K
Y
V
M
V
G
L
F
G
A
D
----
L
---
H
---
Y
--------------
H
A
P
L
I
T
-
L
-
S
E
I
Q
F
V
---------
G
S
L
V
G
N
Q
S
D
F
L
G
I
M
R
L
A
E
A
G
K
V
K
--
P
M
-
I
-
T
--------
K
---
T
M
-
K
L
--
E
E
A
N
E
A
I
D
N
L
E
N
F
-
K
----
A
I
G
R
Q
V
L
I
P
--
50
HHSearch
69.11
25%
-78
- C1 -
3QWB
3
QOR_YEAST
A:
[9-333]
Q
K
V
I
L
I
D
E
I
-----
G
---------------
G
YD---
V
---
I
K
Y
E
-
D
-
Y
P
V
P
S
I
S
--
E
--
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
--
K
G
--
I
-------------
Y
P
----------
C
E
K
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
-
N
F
E
V
G
D
Q
V
A
Y
I
S
-----------------------------------------------------------------------------------------------------------------
N
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
-
P
V
M
K
L
P
K
G
T
S
D
E
E
L
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
--
A
Y
H
-
V
------
K
------
K
G
--
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
-
K
M
K
-
G
-
A
-
H
-
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
-
S
----
K
E
D-----------------
I
L
R
Q
V
L
K
F
T
N
G
K
-
G
V
D
A
S
F
D
S
-
V
G
K
-
D
-
T
F
E
I
S
L
A
A
L
K
R
-
K
G
V
F
V
S
F
G
N
A
S
G
L
----
I
PPF
S
---
I
--------
T
--
R
L
-
S
P
K
N
I
T
-
L
-
V
R
P
Q
L
Y
G
-
Y
I
-----
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
--
I
K
-
I
-
Y
--------
K
---
T
Y
-
P
L
--
R
D
Y
R
T
A
A
A
D
I
E
S
R
-
K
----
T
V
G
K
L
V
L
E
I
P
-
3
PsiBlast_PDB
68.22
28%
-76
- C1 -
2EIH
1
?
A:
[19-341]
------------------------------------------------
D
L
P
V
P
E
--
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
--
K
G
V-
A
-------------
S
P
--------
K
-
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
-
G
F
A
P
G
D
E
V
V
I
N
P
G
---------------------------------------------
L
----------------------------------------
S
CGRC
E
R
C
L
A
GEDNLCPRYQILGEH
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
-
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
---
T
F
L
T
A
W
Q
M
V
V
D
--
K
L
G
-
V
------
R
P
G
---
D
-----
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
-
K
L
F
-
G
-
A
-
R
-
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
----
P
D
------------------
W
P
K
E
V
R
R
L
T
-
G
G
K
G
A
D
K
V
V
D
-
H
T
G
A
-
L
-
Y
F
E
G
V
I
K
A
T
A
N
-
G
G
R
I
-
A
I
A
G
A
S
S
G
----
Y
---
E
---
G
--------
T
--
L
-------
P
-
F
-
A
H
V
F
Y
R
Q
L
S
I
L
G
S
T
M
A
S
K
S
R
L
F
P
I
L
----
R
F
V
E
E
G
K
L
K
--
P
V
-
V
-
G
--------
Q
---
V
L
-
P
L
E
A
A
A
--
E
G
H
R
L
L
E
E
R
-
R
----
V
F
G
K
V
V
L
Q
---
36
HHSearch
67.70
23%
-72
* C1 *
3JYN
1
?
A:
[2-325]
A
K
R
I
Q
F
S
T
V
-----
G
G
P-------------
E
-----
V
---
L
E
Y
V
-
D
-
F
E
P
E
A
P
G
--
P
--
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
--
S
G
--
L
-------------
Y
P
--------
A
-
P
F
L
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
-
R
F
K
V
G
D
R
V
A
Y
G
T
G
---------------------------------------------------------------------------------------------------------------
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
-
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
A
A
L
M
L
---
K
G
L
T
V
Q
Y
L
L
R
Q
--
T
Y
Q
-
V
------
K
------
P
G
--
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
-
K
A
L
-
G
-
A
-
K
-
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
-
S
----
H
E
D-----------------
V
A
K
R
V
L
E
L
T
D
G
K
-
K
C
P
V
V
Y
D
G
-
V
G
Q
-
D
-
T
W
L
T
S
L
D
S
V
A
P
-
R
G
L
V
V
S
F
G
N
A
S
G
P
----
V
S
GV
N
---
L
--------
G
--
I
L
-
A
Q
K
D
S
V
Y
V
-
T
R
P
T
L
-
G
--
S
Y
A
---
N
N
A
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
--
V
D
-
G
-
I
--------
E
---
Q
Y
-
A
L
--
K
D
A
A
K
A
Q
I
E
L
S
A
R
-
R
----
T
T
G
S
T
I
L
I
P
--
33
HHSearch
67.49
21%
-86
- C1 -
3S2E
7
?
A:
[3-340]
M
K
A
A
V
V
R
A
F
-----
G
---------------
A
-----
P
---
L
T
I
D
-
E
-
V
P
V
P
Q
P
G
--
P
--
G
Q
V
Q
V
K
I
E
A
S
G
V
C
H
T
D
L
H
A
A
--
D
G
--
D
-------------
W
P
--------
V
K
P
T
L
P
F
I
P
G
H
E
G
V
G
Y
V
S
A
V
G
S
G
V
S
-
R
V
K
E
G
D
R
V
G
V
P
W
L
YSACGYC
E
H
C
L
Q
GWETLCEK
Q
Q
N
T
G--------------------
Y
----------------------------------------
S
------------------------
V
N
G
G
Y
G
E
Y
V
V
A
D
P
-
N
-
Y
V
G
L
L
P
D
K
V
G
F
V
E
I
A
P
I
L
C
---
A
G
V
T
V
Y
K
G
L
K
---
V
T
D
-
T
------
R
------
P
G
--
Q
W
V
V
I
S
G
I
-
G
G
L
G
H
V
A
V
Q
Y
A
-
R
A
M
-
G
-
L
-
R
-
V
A
A
V
D
I
D
D
A
K
L
N
L
A
R
R
L
G
A
E
V
A
V
N
A
-
R
----
D
T
D-----------------
P
A
A
W
L
Q
K
E
I
-
G
G
-
A
H
G
V
L
V
T
A
-
V
S
P
-
K
-
A
F
S
Q
A
I
G
M
V
R
R
-
G
G
T
I
A
L
N
G
L
P
P
G
D
----
F
---
G
---
T
--------
P
I
F
D
V
-
V
L
K
G
I
T
-
I
-
R
--------------
G
S
I
V
G
T
R
S
D
L
Q
E
S
L
D
F
A
A
H
G
D
V
K
--
A
T
-
V
----------
S
---
T
A
-
K
L
--
D
D
V
N
D
V
F
G
R
L
R
E
G
-
K
----
V
E
G
R
V
V
L
D
F
S
R
47
HHSearch
66.85
24%
-80
- C1 -
2D8A
6
TDH_PYRHO
A:
[5-347]
M
V
A
I
M
K
T
K
P
-----
G
---------------
Y
-----
G
---
A
E
L
V
-
E
-
V
D
V
P
K
P
G
--
P
--
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
--
E
W
--
N
-------------
E
W
A
Q
S
-----
R
-
I
K
P
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
-
G
I
E
V
G
D
Y
V
S
V
E
T
H
---------------------------------------------
I
VCGKCYTKIFGV----------------------------
D
------------------------
T
D
G
V
F
A
E
Y
A
V
V
P
A
-
Q
-
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
L
Q
E
----
P
L
G
N
A
V
D
T
V
L
----
A
G
-
P
------
I
------
S
G
--
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
-
K
A
S
-
G
-
A
-
Y
P
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
V
I
N
P
-
F
----
E
E
D-----------------
V
V
K
E
V
M
D
I
T
D
G
N
-
G
V
D
V
F
L
E
F
-
S
G
A
P
K
-
A
L
E
Q
G
L
Q
A
V
T
P
-
A
G
R
V
S
L
L
G
L
Y
P
G
K
----
V
---
T
---
I
--------
D
-----
F
N
N
L
I
I
-
F
-
K
A
L
T
I
Y
G
--------
I
T
G
R
H
L
W
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
LD
P
I
-
I
-
T
--------
H
---
K
Y
K
G
F
--
D
K
Y
E
E
A
F
E
L
M
R
A
G
-
K
-----
T
G
K
V
V
F
M
L
--
51
HHSearch
64.11
27%
-89
- C1 -
3TQH
3
?
A:
[7-321]
M
K
A
I
Q
F
D
Q
F
G
P
---
P
---------------
K
-----
V
---
L
K
L
V
-
D
-
T
P
T
P
E
Y
R
--
K
--
N
Q
M
L
I
K
V
H
A
A
S
L
N
P
I
D
Y
K
T
R
--
N
G
--
S
-------------
G
F
V
A
K
K
L
---
K
-
N
N
L
P
S
G
L
G
Y
D
F
S
G
E
V
I
E
L
G
S
D
V
N
-
N
V
N
I
G
D
K
V
M
G
I
A
G
---------------------------------------------
F
P---------------------------------------
D
------------------------
H
P
C
C
Y
A
E
Y
V
C
A
S
P
-
D
-
T
I
I
Q
K
L
E
K
L
S
F
L
Q
A
A
S
L
P
T
---
A
G
L
T
A
L
Q
A
L
N
Q
---
A
E
-
V
------
K
------
Q
G
--
D
V
V
L
I
H
A
G
A
G
G
V
G
H
L
A
I
Q
L
A
-
K
Q
K
-
G
-
T
-
T
-
V
I
T
T
A
-
S
K
R
N
H
A
F
L
K
A
L
G
A
E
Q
C
I
N
Y
-
H
----
E
E
D-----------------
F
L
L
A
----
I
-
S
T
-
P
V
D
A
V
I
D
L
-
V
G
G
-
D
-
V
G
I
Q
S
I
D
C
L
K
E
-
T
G
C
I
V
S
V
P
T
I
T
A
G
----
R
---
V
---
I
--------
E
--
V
A
-
K
Q
K
H
R
R
-
A
-
F
--
G
L
L
---------
K
--
Q
F
N
I
E
E
L
H
Y
L
G
K
L
V
S
E
D
K
L
R
--
I
E
-
I
-
S
--------
R
---
I
F
-
Q
L
--
S
E
A
V
T
A
H
E
L
L
E
T
G
-
H
----
V
R
G
K
L
V
F
K
V
R
-
42
HHSearch
63.66
20%
-80
- C1 -
2FZW
6
ADHX_HUMAN
A:
[7-367]
C
K
A
A
V
A
W
E
A
-----
G
---------------
K
-----
P
---
L
S
I
E
-
E
-
I
E
V
A
P
P
K
--
A
--
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
T
L
--
S
G
--
A
-------------
D
P
--------
E
-
G
C
F
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
-
K
L
K
A
G
D
T
V
I
P
L
Y
I
PQCGECKFCLNPKTNLCQKI
R
V
T
Q
G
K
GLMPDGTSRFTCKG
K
T
I
L
H
Y
----------------------------------------
M
------------------------
G
T
S
T
F
S
E
Y
T
V
V
A
D
-
I
-
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
---
G
I
S
T
G
Y
G
A
A
V
N
--
T
A
K
-
L
------
E
------
P
G
--
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
-
K
V
A
-
G
-
A
S
R
-
I
I
G
V
D
I
N
K
D
K
F
A
R
A
K
E
F
G
A
T
E
C
I
N
P
-
Q
----
D
F
SKP---------------
I
Q
E
V
L
I
E
M
T
-
D
G
-
G
V
D
Y
S
F
E
C
-
I
G
N
V
K
-
V
M
R
A
A
L
E
A
C
H
K
G
W
G
V
S
V
V
V
G
V
A
A
S
G
----
E
---
E
---
I
A
T
------
R
--
P
F
Q
L
V
T
G
R
T
-
W
-
K
G
T
A
F
----------
G
G
W
K
-
S
V
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
VD
E
F
-
V
-
T
--------
H
---
N
L
-
S
F
--
D
E
I
N
K
A
F
E
L
M
H
S
G
-
K
----
S
I
---------
39
HHSearch
62.31
21%
-72
- C1 -
3JV7
7
?
A:
[1-345]
M
K
A
V
Q
Y
T
E
I
-----
G
---------------
S
-----
E
---
P
V
V
V
-
D
-
I
P
T
P
T
P
G
--
P
--
G
E
I
L
L
K
V
T
A
A
G
L
C
H
S
D
I
F
V
M
--
D
M
--
P
-------------
A
A
QY------
A
-
Y
G
L
P
L
T
L
G
H
E
G
V
G
T
V
A
E
L
G
E
G
V
T
-
G
F
G
V
G
D
A
V
A
V
Y
G
P
---------------------------------------------
W
GCGAC
H
A
C
A
R
GRENYCTRAADLGITPPGL-----------
G
------------------------
S
P
G
S
M
A
E
Y
M
I
V
D
S
-
A
R
H
L
V
P
I
G
-
D
L
D
P
V
A
A
A
P
L
T
D
---
A
G
L
T
P
Y
H
A
I
S
R
--
V
L
P
L
L
------
G
------
P
G
--
S
T
A
V
V
I
G
V
-
G
G
L
G
H
V
G
I
Q
I
L
-
R
A
V
-
S
-
A
A
R
-
V
I
A
V
D
L
D
D
D
R
L
A
L
A
R
E
V
G
A
D
A
A
V
K
S
-
G
----
A
G
------------------
A
A
D
A
I
R
E
L
T
G
G
Q
-
G
A
T
A
V
F
D
F
-
V
G
A
Q
S
-
T
I
D
T
A
Q
Q
V
V
A
V
-
D
G
H
I
S
V
V
G
I
H
A
G
A
----
H
---
A
---
K
------------------
V
G
-
F
-
F
M
I
P
F
G
A
--
S
V
V
---
T
P
Y
W
G
T
R
S
E
L
M
E
V
V
A
L
A
R
A
G
R
L
D
--
I
--
H
-
T
--------
E
---
T
F
-
T
L
--
D
E
G
P
A
A
Y
R
R
L
R
E
G
-
S
----
I
R
G
R
G
V
V
V
P
--
49
HHSearch
61.18
21%
-78
- C1 -
1F8F
6
?
A:
[7-370]
I
I
A
A
V
T
P
C
K
-----
G
---------------
A
-----
D
---
F
E
L
Q
-
A
-
L
K
I
R
Q
P
Q
--
G
--
D
E
V
L
V
K
V
V
A
T
G
M
C
H
T
D
L
I
V
R
--
D
Q
--
K
-------------
Y
P
----------
V
P
L
P
A
V
L
G
H
E
G
S
G
I
I
E
A
I
G
P
N
V
T
-
E
L
Q
V
G
D
H
V
V
L
S
Y
G
---------------------------------------------
Y
CGKC
T
Q
C
N
T
GNPAYCSEFFGRNFSGADSEGNHALCVNDHF
F
------------------------
A
Q
S
S
F
A
T
Y
A
L
S
R
E
-
N
-
N
T
V
K
V
T
K
D
V
P
I
E
L
L
G
P
L
G
C
---
G
I
Q
T
G
A
G
A
C
I
N
--
A
L
K
-
V
------
T
------
P
A
--
S
S
F
V
T
W
G
A
-
G
A
V
G
L
S
A
L
L
A
A
-
K
V
C
-
G
-
A
-
S
I
I
I
A
V
D
I
V
E
S
R
L
E
L
A
K
Q
L
G
A
T
H
V
I
N
S
-
K
----
T
Q
D-----------------
P
V
A
A
I
K
E
I
T
-
D
G
-
G
V
N
F
A
L
E
S
-
T
G
S
P
E
-
I
L
K
Q
G
V
D
A
L
G
I
-
L
G
K
I
A
V
V
G
A
P
Q
L
G
T
T
A
Q
F
---
D
---
V
--------
N
--
D
L
-
L
L
G
G
K
T
-
I
-
L
G
V
V
E
-----------
G
S
G
S
P
K
K
F
I
P
E
L
V
R
L
Y
Q
Q
G
K
F
P
--
F
D
Q
L
-
V
--------
K
---
F
Y
-
A
F
--
D
E
I
N
Q
A
A
I
D
S
R
K
G
-
I
-----
T
L
K
P
I
I
K
I
--
38
HHSearch
60.10
20%
-74
- C1 -
3GMS
-
?
A:
[3-330]
G
K
L
I
Q
F
H
K
F
-----
G
---------------
N
PKD--
V
---
L
Q
V
E
-
Y
-
K
N
I
E
P
L
K
--
D
--
N
E
V
F
V
R
M
L
V
R
P
I
N
P
S
D
L
I
P
I
--
T
G
--
A
-------------
Y
A
--------
H
R
I
P
L
P
N
I
P
G
Y
E
G
V
G
I
V
E
N
V
G
A
F
V
S
-
R
E
L
I
G
K
R
V
L
P
L
R
----------------------------------------------------------------------------------------------------------------
G
E
G
T
W
Q
E
Y
V
K
T
S
A
-
D
-
F
V
V
P
I
P
D
S
I
D
D
F
T
A
A
Q
M
Y
I
---
N
P
L
T
A
W
V
T
C
T
E
--
T
L
N
-
L
------
Q
------
R
N
--
D
V
L
L
V
N
A
C
G
S
A
I
G
H
L
F
A
Q
L
S
-
Q
I
L
-
N
-
F
-
R
-
L
I
A
V
T
R
N
N
K
H
T
E
E
L
L
R
L
G
A
A
Y
V
I
D
T
-
S
----
T
A
P-----------------
L
Y
E
T
V
M
E
L
T
N
G
I
-
G
A
D
A
A
I
D
S
-
I
G
G
-
P
-
D
G
N
E
L
A
F
S
L
R
P
-
N
G
H
F
L
T
I
G
L
L
S
G
I
Q---
V
---
N
---
W
--------
A
--
E
I
-
V
T
K
A
K
V
-
H
A
N
I
F
H
L
R
H
W
-
N
D
E
---
V
S
P
Y
K
W
Q
E
T
F
R
H
L
I
R
L
V
E
N
E
Q
L
R
--
F
M
K
V
-
H
--------
S
---
T
Y
-
E
L
--
A
D
V
K
A
A
V
D
V
V
Q
S
A
E
K
----
T
K
G
K
V
F
L
T
S
Y
-
13
PsiBlast_PDB
59.96
29%
-65
- C1 -
4IDE
5
ENOXC_FRAAN
A:
[35-329]
--------------
T
---------------
S
-----
D
---
V
L
-
K
-
F
D
P
S
V
A
V
P
E
I
K
E
--
D
Q
V
L
I
K
V
V
A
A
S
L
N
P
V
D
F
K
R
A
--
L
G
YF
K
-------------
D
T
--------
D
-
S
P
L
P
T
I
P
G
Y
D
V
A
G
V
V
V
K
V
G
S
Q
V
T
-
K
F
K
V
G
D
E
V
Y
--
G
D
---------------------------------------------
L
NETALVNP--------------------------------
T
------------------------
R
F
G
S
L
A
E
Y
T
A
A
D
E
-
R
-
V
L
A
H
K
P
K
N
L
S
F
I
E
A
A
S
L
P
L
---
A
I
E
T
A
H
E
G
L
-
E
--
R
----------
A
E
L
---
S
A
G
--
K
S
V
L
V
L
G
G
A
G
G
V
G
T
H
I
I
Q
L
A
-
K
H
V
F
G
-
A
-
S
-
K
V
A
A
T
A
S
T
K
K
L
D
L
L
R
T
L
G
A
D
L
A
I
D
Y
-
T
KENF
E
D
------------------
L
P
E
K
F
D
-------------
V
V
Y
D
A
V
-
G
-
E
T
D
K
A
V
K
A
V
K
E
-
G
G
K
V
V
T
I
V
G
P
A
T
P
----
P
---
A
---
I
--------
L
-----------------
F
V
L
T
-
S
K
G
S
V
--
L
E
K
L
K
P
Y
---------
L
E
S
G
K
V
K
--
P
V
-
L
-
D
--------
P
---
T
-
S
P
Y
P
F
T
K
V
V
E
A
F
G
Y
L
E
S
S
-
R
----
A
T
G
K
V
V
V
----