@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2663: (2016-04-06 )
LKAVVKTNPGYDQMELKDVEEPQVYGDKVKIKVAFTGICGSDIHTFKGEYKNPTTPVTLGHEFSGVVVEVGPDVTSIKVGDRVTSETTFETCGECIYCKEHDYNLCSNRRGIGTQANGSFAEFVLSREESCHVLDERISLEAAALTEPLACCVHSALEKTTIRPDDTVLVFGPGPIGLLLAQVVKAQGATVIMAGITKDSDRLRLAKELGMDRIVDTLKEDLAEVVLGMTGGYGAERVFDCSGAVPAVNQGLPLTKKKGDFVQVGLFAEKKNAIDEESIIQREIAYIGSRSQKPSSWILALDLLANGKIDTDKMITKVYGLDDWREAFEAVMAGNEIKVLVKS
Atome Classification :
(20 SA)
.........10-..-......20........30........40......----..---50---..--..--....60........70........80........90........100.......110---------------------...-------------------------.-...120.......130.......140..-.....150---.......160.......170.-......180.......-190........200........210--.......220-........230-...--.--....240.......250.....-.-.260.......-270....-.-..280-.........290---.-.---.....300.......310.......-320.......330--...-....340.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
K
A
V
V
KTNPGY-DQ-MELKDVEEPQVYG
D
K
V
K
I
K
V
A
F
TGICGSDIHTFK----GE---YK---NP--TT--
P
V
T
LGHEFS
G
V
V
V
EVGP
D
V
T
S
I
K
VGDRVTSE
T
T
F
E
T
CG
E
C
I
Y
CKEHDYNLCSNRRGI---------------------GTQ-------------------------A-N
G
S
F
A
E
F
V
L
SREES
C
H
V
L
D
E
R
IS
L
E
A
A
A
-
L
T
E
P
L
A
C
C
---
V
H
S
A
L
E
KTTIRPD
D
T
V
L
V
FGP-G
P
I
G
L
L
L
A
Q
V
V
KAQG
A
-
T
-
V
I
M
AGITK
D
S
D
-
R
L
R
L
A
K
E
L
G
M
D
--
R
I
V
D
T
L
K
E
D
--
L
A
E
V
V
L
GMTG--GYG--
A
--
E
R
V
FDCSGAVPAVNQGLPLTKK-K-G
D
F
V
Q
V
G
L
F
AE-KKNAI
D
E
-
E
-
S
I
I
---
Q
R
E
I
A
Y
IGSRSQ---K-P---S
S
W
I
L
A
L
D
LLANGKI
D
T
D
K
M
I
T
K
VY-G
L
D
D
W
R
E
A
F
E
A
V
M--AG
N
-
E
I
K
V
L
V
KS
8
PsiBlast_PDB
90.42
33%
-89
- C1 -
1E3J
4
?
A:
[17-347]
-------------
R
-
L
E
Q
R
P
I
P
E
P
K
--
E
D
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
H
Y
Y
E
H---
G
R
---
I
A
---
D
F
--
I
V
K
D
P
M
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
G
V
-
P
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
C
---------------------
A
T
P
-------------------------
P
D
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
K
L
P
D
N
V
S
L
E
E
G
A
-
L
L
E
P
L
S
V
G
---
V
H
-
A
C
R
R
A
G
V
Q
L
G
T
T
V
L
V
I
G
A
-
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
-
F
-
V
V
C
T
A
--
R
S
P
R
-
R
L
E
V
A
K
N
C
G
A
D
VT
L
V
V
D
P
A
K
E
E
--
E
S
S
I
I
E
R
I
R
S
--
A
I
G
DL
P
--
N
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
I
T
R
T
-
G
-
G
T
L
M
L
V
G
M
-
G
S
-
Q
M
V
T
V
P
L
-
V
-
N
A
C
---
A
R
E
I
D
-
I
K
S
V
F
R
---
Y
-
C
---
N
D
Y
P
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
-
K
L
E
Q
T
V
D
A
F
E
A
A
R
K
K
A
D
N
-
T
I
K
V
M
I
--
2
PsiBlast_PDB
89.95
35%
-83
- C1 -
4EJM
5
?
A:
[34-360]
-------------
N
-
I
S
V
R
N
V
G
I
P
E
P
G
P
D
D
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
H
L
L
H
----
G
E
---
F
P
---
S
---
T
P
--
P
V
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
-
S
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
---------------------
G
I
H
-------------------------
R
-
D
G
G
F
A
E
Y
V
L
V
P
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
-
F
C
E
P
L
A
C
C
---
L
H
-
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
-
G
V
I
G
L
L
T
V
Q
L
A
R
L
A
G
A
-
T
-
T
V
I
L
S
-
T
R
Q
A
T
-
K
R
R
L
A
E
E
V
G
A
T
--
A
T
V
D
P
S
A
G
D
--
V
V
E
A
I
A
G
P
V
G
LV
P
G
G
--
V
--
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
-
G
-
G
T
V
V
I
L
G
V
L
P
Q
G
E
K
V
E
I
E
P
-
F
-
D
I
L
---
F
R
E
L
R
V
L
G
S
-
F
I
---
N
-
P
---
F
V
H
R
R
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
-
S
L
D
E
A
P
D
V
I
S
N
P
A
--
A
A
G
-
E
V
K
V
L
V
--
1
PsiBlast_PDB
88.02
35%
-83
- C1 -
4EJ6
19
?
A:
[34-360]
-------------
N
-
I
S
V
R
N
V
G
I
P
E
P
G
P
D
D
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
H
L
L
H
----
G
E
---
F
P
---
S
---
T
P
--
P
V
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
-
S
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
---------------------
G
I
H
-------------------------
R
-
D
G
G
F
A
E
Y
V
L
V
P
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
-
F
C
E
P
L
A
C
C
---
L
H
-
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
-
G
V
I
G
L
L
T
V
Q
L
A
R
L
A
G
A
-
T
-
T
V
I
L
S
-
T
R
Q
A
T
-
K
R
R
L
A
E
E
V
G
A
T
--
A
T
V
D
P
S
A
G
D
--
V
V
E
A
I
A
G
P
V
G
LV
P
G
G
--
V
--
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
-
G
-
G
T
V
V
I
L
G
V
L
P
Q
G
E
K
V
E
I
E
P
-
F
-
D
I
L
---
F
R
E
L
R
V
L
G
S
-
F
I
---
N
-
P
---
F
V
H
R
R
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
-
S
L
D
E
A
P
D
V
I
S
N
P
A
--
A
A
G
-
E
V
K
V
L
V
--
51
HHSearch
87.43
36%
-85
- C1 -
2D8A
6
TDH_PYRHO
A:
[5-346]
M
V
A
I
M
K
T
K
P
G
---
Y
G
A
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
----
W
N
---
E
W
A
Q
S
R
I
--
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
-
I
V
C
G
K
C
Y
------------
T
K
I
F
---------------------
G
V
D
-------------------------
T
-
D
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
--
A
G
P
I
S
G
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
P
V
I
V
--
S
E
P
S
D
F
-
R
R
E
L
A
K
K
V
G
A
D
--
Y
V
I
N
P
F
E
E
D
--
V
V
K
E
V
M
D
I
T
D
--
G
N
G
--
V
--
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
-
A
-
G
R
V
S
L
L
G
L
Y
P
G
-
K
-
V
T
I
D
F
-
N
N
L
I
I
---
F
K
A
L
T
I
Y
G
I
T
G
R
H--
L
-
W
---
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
F
M
-
5
PsiBlast_PDB
82.65
34%
-82
- C1 -
2DFV
3
TDH_PYRHO
A:
[6-343]
--
A
I
M
K
T
K
P
G
Y
-
G
--
A
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
R
I
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
I
-
V
C
G
K
C
Y
A
C
R
R
G
Q
Y
H
V
C
Q
N
T
K
I
F
---------------------
G
V
D
-------------------------
T
-
D
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
--
S
G
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
--
Y
V
I
N
P
F
E
E
D
--
V
V
K
E
V
M
D
I
T
D
--
G
N
G
--
V
--
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
-
A
-
G
R
V
S
L
L
G
L
Y
P
G
-
K
V
T
I
D
F
N
-
N
-
L
I
I
---
F
K
A
L
T
I
Y
G
I
T
G
R
---
H
L
W
---
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
23
PsiBlast_CBE
81.82
34%
-86
- C1 -
3GFB
7
TDH_THEKO
B:
[5-344]
M
Q
A
I
M
K
T
K
P
A
Y
-
G
A
--
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
RI
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
-
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
---------------------
G
V
D
-------------------------
M
-
D
G
V
F
A
H
Y
A
I
V
P
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
A
--
G
R
S
T
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
--
Y
V
V
N
P
F
E
E
D
--
P
V
K
F
V
M
D
I
T
D
--
G
A
G
--
V
--
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
-
G
-
G
R
V
S
L
L
G
L
F
P
--
R
E
V
T
I
D
F
-
N
-
N
L
I
IFK
A
L
E
V
H
G
I
T
G
R
H
L
---
W
-----
E
T
W
Y
T
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
22
PsiBlast_CBE
80.72
34%
-83
- C1 -
3GFB
6
TDH_THEKO
C:
[5-344]
M
Q
A
I
M
K
T
K
P
A
Y
-
G
A
--
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
RI
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
-
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
---------------------
G
V
D
-------------------------
M
-
D
G
V
F
A
H
Y
A
I
V
P
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
A
--
G
R
S
T
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
--
Y
V
V
N
P
F
E
E
D
--
P
V
K
F
V
M
D
I
T
D
--
G
A
G
--
V
--
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
-
G
-
G
R
V
S
L
L
G
L
F
P
--
R
E
V
T
I
D
F
-
N
-
N
L
I
IFK
A
L
E
V
H
G
I
T
G
R
H
L
---
W
-----
E
T
W
Y
T
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
3
PsiBlast_PDB
80.40
34%
-82
- C1 -
3GFB
2
TDH_THEKO
A:
[5-344]
M
Q
A
I
M
K
T
K
P
A
Y
-
G
A
--
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
R
I
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
-
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
---------------------
G
V
D
-------------------------
M
-
D
G
V
F
A
H
Y
A
I
V
P
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
A
--
G
R
S
T
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
--
Y
V
V
N
P
F
E
E
D
--
P
V
K
F
V
M
D
I
T
D
--
G
A
G
--
V
--
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
-
G
-
G
R
V
S
L
L
G
L
F
P
--
R
E
V
T
I
D
F
-
N
-
N
L
I
IFK
A
L
E
V
H
G
I
T
G
R
H
L
---
W
-----
E
T
W
Y
T
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
4
PsiBlast_PDB
79.72
34%
-82
- C1 -
2D8A
6
TDH_PYRHO
A:
[7-344]
--
A
I
M
K
T
K
P
G
Y
-
G
--
A
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
RI
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
I
-
V
C
G
K
C
Y
------------
T
K
I
F
---------------------
G
V
D
-------------------------
T
-
D
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
--
S
G
K
S
V
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
--
Y
V
I
N
P
F
E
E
D
--
V
V
K
E
V
M
D
I
T
D
--
G
N
G
--
V
--
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
-
A
-
G
R
V
S
L
L
G
L
Y
P
G
-
K
V
T
I
D
F
N
-
N
-
L
I
I
---
F
K
A
L
T
I
Y
G
I
T
G
R
---
H
L
W
---
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
21
PsiBlast_CBE
79.41
34%
-83
- C1 -
3GFB
4
TDH_THEKO
D:
[5-344]
M
Q
A
I
M
K
T
K
P
A
Y
-
G
A
--
E
L
V
E
V
D
V
P
K
P
G
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
W---
N
E
---
W
A
---
Q
S
RI
K
P
--
P
Q
I
M
G
H
E
V
A
G
E
V
V
E
V
G
P
G
V
E
D
L
Q
V
G
D
Y
I
S
V
E
T
H
I
-
V
C
G
K
C
Y
A
C
K
H
N
R
Y
H
V
C
Q
N
T
K
I
F
---------------------
G
V
D
-------------------------
M
-
D
G
V
F
A
H
Y
A
I
V
P
A
K
N
A
W
K
N
P
K
D
M
P
P
E
Y
A
A
-
L
Q
E
P
L
G
N
A
---
V
D
T
V
L
A
G
P
I
A
--
G
R
S
T
L
I
T
G
A
-
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
-
Y
-
P
V
I
--
V
S
E
P
S
E
F
R
R
K
L
A
K
K
V
G
A
D
--
Y
V
V
N
P
F
E
E
D
--
P
V
K
F
V
M
D
I
T
D
--
G
A
G
--
V
--
E
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
K
A
V
T
P
-
G
-
G
R
V
S
L
L
G
L
F
P
--
R
E
V
T
I
D
F
-
N
-
N
L
I
IFK
A
L
E
V
H
G
I
T
G
R
H
L
---
W
-----
E
T
W
Y
T
V
S
S
L
I
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
K
G
F
D
K
F
E
E
A
F
E
L
M
R
--
A
G
K
-
T
G
K
V
V
---
7
PsiBlast_PDB
77.09
31%
-75
- C1 -
2EJV
4
TDH_THET8
A:
[1-339]
M
R
A
L
A
K
L
A
P
-
E
-
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
A
W
A
R
G
---
R
I
--
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
-
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
---------------------
G
V
D
-------------------------
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
-
I
L
E
P
F
G
N
A
---
V
H
T
V
Y
A
G
S
G
V
S
-
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
-
G
-
P
I
L
V
S
-
D
P
N
P
Y
-
R
L
A
F
A
R
P
Y
A
-
D
--
R
L
V
N
P
L
E
E
D
--
L
L
E
V
V
R
R
V
T
G
--
S
-
G
--
V
--
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
-
G
-
G
E
A
R
I
L
G
I
P
S
D
-
P
I
R
F
D
L
A
-
G
-
E
L
V
---
M
R
G
I
T
A
F
G
I
A
G
R
---
R
L
W
---
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
--
S
G
Q
-
A
V
K
V
I
L
--
24
PsiBlast_CBE
76.17
31%
-72
- C1 -
2EJV
4
TDH_THET8
B:
[1-339]
M
R
A
L
A
K
L
A
P
-
E
-
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
AWA
R
G
---
R
I
--
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
-
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
---------------------
G
V
D
-------------------------
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
-
I
L
E
P
F
G
N
A
---
V
H
T
V
Y
A
G
S
G
V
S
-
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
-
G
-
P
I
L
V
S
-
D
P
N
P
Y
-
R
L
A
F
A
R
P
Y
A
-
D
--
R
L
V
N
P
L
E
E
D
--
L
L
E
V
V
R
R
V
T
G
--
S
-
G
--
V
--
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
-
G
-
G
E
A
R
I
L
G
I
P
S
D
-
P
I
R
F
D
L
A
-
G
-
E
L
V
---
M
R
G
I
T
A
F
G
I
A
G
R
---
R
L
W
---
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
--
S
G
Q
-
A
V
K
V
I
L
--
6
PsiBlast_PDB
74.94
31%
-72
- C1 -
2DQ4
3
TDH_THET8
A:
[1-339]
M
R
A
L
A
K
L
A
P
-
E
-
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
A
W
A
R
G
---
R
I
--
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
-
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
---------------------
G
V
D
-------------------------
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
-
I
L
E
P
F
G
N
A
---
V
H
T
V
Y
A
G
S
G
V
S
-
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
-
G
-
P
I
L
V
S
-
D
P
N
P
Y
-
R
L
A
F
A
R
P
Y
A
-
D
--
R
L
V
N
P
L
E
E
D
--
L
L
E
V
V
R
R
V
T
G
--
S
-
G
--
V
--
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
-
G
-
G
E
A
R
I
L
G
I
P
S
D
-
P
I
R
F
D
L
A
-
G
-
E
L
V
---
M
R
G
I
T
A
F
G
I
A
G
R
---
R
L
W
---
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
--
S
G
Q
-
A
V
K
V
I
L
--
50
HHSearch
74.08
32%
-74
* C1 *
2DQ4
3
TDH_THET8
A:
[1-341]
M
R
A
L
A
K
L
A
P
E
--
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
---
A
W
A
R
G
R
I
--
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
-
I
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
---------------------
G
V
D
-------------------------
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
-
I
L
E
P
F
G
N
A
---
V
H
T
V
Y
A
-
G
S
G
V
S
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
-
G
P
I
L
V
--
S
D
P
N
P
Y
-
R
L
A
F
A
R
P
Y
-
A
D
--
R
L
V
N
P
L
E
E
D
--
L
L
E
V
V
R
R
V
T
---
G
S
G
--
V
--
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
-
G
-
G
E
A
R
I
L
G
I
P
S
D
-
P
-
I
R
F
D
L
A
G
-
E
L
V
---
M
R
G
I
T
A
F
G
I
A
G
R
---
R
L
W
---
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
--
S
G
Q
-
A
V
K
V
I
L
D
P
25
PsiBlast_CBE
73.44
31%
-72
- C1 -
2DQ4
3
TDH_THET8
B:
[1-339]
M
R
A
L
A
K
L
A
P
-
E
-
E
G
-
L
T
L
V
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
AWA
R
G
---
R
I
--
R
P
--
P
L
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
-
V
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
---------------------
G
V
D
-------------------------
R
-
D
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
-
I
L
E
P
F
G
N
A
---
V
H
T
V
Y
A
G
S
G
V
S
-
G
K
S
V
L
I
T
G
A
-
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
-
G
-
P
I
L
V
S
-
D
P
N
P
Y
-
R
L
A
F
A
R
P
Y
A
-
D
--
R
L
V
N
P
L
E
E
D
--
L
L
E
V
V
R
R
V
T
G
--
S
-
G
--
V
--
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
-
G
-
G
E
A
R
I
L
G
I
P
S
D
-
P
I
R
F
D
L
A
-
G
-
E
L
V
---
M
R
G
I
T
A
F
G
I
A
G
R
---
R
L
W
---
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
-
P
L
S
R
Y
R
E
A
F
G
L
L
A
--
S
G
Q
-
A
V
K
V
I
L
--
48
HHSearch
73.37
27%
-76
- C1 -
2EIH
1
?
A:
[1-341]
M
R
A
V
V
M
R
A
R
G
G
P
E
V
-
L
E
V
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
----
G
V
---
A
S
P--
K
L
--
P
L
--
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
F
A
P
G
D
E
V
V
I
N
P
G
-
L
S
C
G
R
C
E
R
C
L
A
G
E
D
N
L
C
P
R
Y
Q
I
L
---------------------
G
E
H
-------------------------
R
-
H
G
T
Y
A
E
Y
V
V
L
P
E
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
---
W
Q
M
V
V
D
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
-
R
-
V
I
A
--
T
A
G
S
E
D
-
K
L
R
R
A
K
A
L
G
A
D
--
E
T
V
N
Y
T
H
P
D
--
W
P
K
E
V
R
R
L
T
G
--
G
K
G
--
A
--
D
K
V
V
D
H
T
G
A
L
-
Y
F
E
G
V
I
K
A
T
A
N
-
G
-
G
R
I
A
I
A
G
A
S
S
G
-
Y
E
G
T
L
P
F
-
A
-
H
V
F
---
Y
R
Q
L
S
I
L
G
S
T
M
A
---
S
-
K
---
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
--
K
P
V
V
G
Q
V
L
-
P
L
E
A
A
A
E
G
H
R
L
L
E
--
E
R
R
V
F
G
K
V
V
L
Q
-
52
HHSearch
71.41
25%
-83
- C1 -
1E3I
4
ADH4_MOUSE
A:
[9-374]
C
K
A
A
I
A
W
K
T
G
--
S
P
-
L
C
I
E
E
I
E
V
S
P
P
K
A
C
E
V
R
I
Q
V
I
A
T
C
V
C
P
T
D
I
N
A
T
D
----
P
K
---
K
----
K
A
--
L
F
--
P
V
V
L
G
H
E
C
A
G
I
V
E
S
V
G
P
G
V
T
N
F
K
P
G
D
K
V
I
P
F
F
A
-
P
Q
C
K
R
C
K
L
C
L
S
P
L
T
N
L
C
G
K
L
R
N
F
---------------------
K
Y
P
TIDQELMEDRTSRFTCKG
R
S
I
Y
H
F
M
G
-
V
S
S
F
S
Q
Y
T
V
V
S
E
A
N
L
A
R
V
D
D
E
A
N
L
E
R
V
C
L
I
G
C
G
F
S
S
G
---
Y
G
A
A
I
N
T
A
K
V
T
P
G
S
T
C
A
V
F
G
L
-
G
C
V
G
L
S
A
I
I
G
C
K
I
A
G
A
S
R
-
I
I
A
--
I
D
I
N
G
E
-
K
F
P
K
A
K
A
L
G
A
T
--
D
C
L
N
P
R
E
L
D
KP
V
Q
D
V
I
T
E
L
T
A
---
G
G
--
V
--
D
Y
S
L
D
C
A
G
T
A
Q
T
L
K
A
A
V
D
C
T
V
L
-
G
W
G
S
C
T
V
V
G
A
K
V
D
--
E
M
T
I
P
T
-
V
-
D
V
I
----
L
G
R
S
I
N
G
T
F
F
G
GWK
S
-
V
---
D
S
V
P
N
L
V
S
D
Y
K
N
K
K
F
D
L
D
L
L
V
T
H
A
L
-
P
F
E
S
I
N
D
A
I
D
L
M
K
--
E
G
K
-
S
I
R
T
I
L
--
16
PsiBlast_PDB
71.29
29%
-76
- C1 -
3QE3
4
DHSO_SHEEP
A:
[9-347]
--
S
L
V
V
H
G
P
G
D
-
L
R
-
L
E
N
Y
P
I
P
E
P
G
--
P
N
E
V
L
L
K
M
H
S
V
G
I
C
G
S
D
V
H
Y
W
Q
HGRI
G
D
---
F
V
---
V
---
K
K
--
P
M
V
L
G
H
E
A
S
G
T
V
V
K
V
G
S
L
V
R
H
L
Q
P
G
D
R
V
A
I
Q
P
G
A
P
R
Q
T
D
-
E
F
C
K
I
G
R
Y
N
L
S
P
T
I
F
F
C
---------------------
A
T
P
-------------------------
P
D
D
G
N
L
C
R
F
Y
K
H
N
A
N
F
C
Y
K
L
P
D
N
V
T
F
E
E
G
A
-
L
I
E
P
L
S
V
G
---
I
H
-
A
C
R
R
A
G
V
T
L
G
N
K
V
L
V
C
G
A
-
G
P
I
G
L
V
N
L
L
A
A
K
A
M
G
A
-
A
-
Q
V
V
V
-
T
D
L
S
A
S
-
R
L
S
K
A
K
E
V
G
A
D
--
F
I
L
E
I
S
N
E
S
--
P
E
E
I
A
K
K
V
E
G
--
L
L
G
--
S
KP
E
V
T
I
E
C
T
G
V
E
T
S
I
Q
A
G
I
Y
A
T
H
S
-
G
-
G
T
L
V
L
V
G
L
G
S
E
--
M
T
S
V
P
L
-
V
-
H
A
A
---
T
R
E
V
D
I
K
G
V
-
F
R
---
Y
-
C
---
N
T
W
P
M
A
I
S
M
L
A
S
K
S
V
N
V
K
P
L
V
T
H
R
F
-
P
L
E
K
A
L
E
A
F
E
T
S
K
--
K
G
L
-
G
L
K
V
M
I
K
-
59
HHSearch
70.64
27%
-78
- C1 -
2FZW
6
ADHX_HUMAN
A:
[7-371]
C
K
A
A
V
A
W
E
A
G
--
K
P
-
L
S
I
E
E
I
E
V
A
P
P
K
A
H
E
V
R
I
K
I
I
A
T
A
V
C
H
T
D
A
Y
T
L
S
----
G
A
---
D
P
---
E
G
--
C
F
--
P
V
I
L
G
H
L
G
A
G
I
V
E
S
V
G
E
G
V
T
K
L
K
A
G
D
T
V
I
P
L
Y
I
-
P
Q
C
G
E
C
K
F
C
L
N
P
K
T
N
L
C
Q
K
I
R
V
T
Q
G
K
GLMPDGTSRFTCKG
K
T
I
L
H
Y
M
-------------------------
G
-
T
S
T
F
S
E
Y
T
V
V
A
D
I
S
V
A
K
I
D
P
L
A
P
L
D
K
V
C
L
L
G
C
G
I
S
T
G
---
Y
G
A
A
V
N
T
A
K
L
E
P
G
S
V
C
A
V
F
G
L
-
G
G
V
G
L
A
V
I
M
G
C
K
V
A
G
A
-
S
R
I
I
G
--
V
D
I
N
K
D
-
K
F
A
R
A
K
E
F
G
A
T
--
E
C
I
N
P
Q
D
F
S
KP
I
Q
E
V
L
I
E
M
T
---
D
G
G
--
V
--
D
Y
S
F
E
C
I
G
N
V
K
V
M
R
A
A
L
E
A
C
H
K
G
W
-
G
V
S
V
V
V
G
V
A
A
S
G
E
E
I
A
T
R
P
---
F
Q
L
---
V
T
G
R
T
W
K
G
T
A
F
G
---
G
-
W
KSV
E
S
V
P
K
L
V
S
E
Y
M
S
K
K
I
K
V
D
E
F
V
T
H
N
L
-
S
F
D
E
I
N
K
A
F
E
L
M
H
--
S
G
K
-
S
I
R
T
V
V
--
10
PsiBlast_PDB
70.54
31%
-88
- C1 -
3PII
5
ADH3_GEOSE
A:
[11-327]
------------
E
P
-
L
K
I
K
E
V
E
K
P
T
I
S
Y
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
---
W
P
V
--
K
P
--
K
L
--
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
G
I
P
W
L
Y
S
A
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
---------------------
G
Y
S
-------------------------
V
-
D
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
----
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
-
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
-
V
V
A
V
D
I
--
G
D
E
-
K
L
E
L
A
K
E
L
G
A
D
--
L
V
V
N
P
L
K
E
D
--
A
A
K
F
M
K
E
K
V
G
--
G
V
H
--
A
--
A
V
V
T
A
V
S
K
--
P
A
F
Q
S
A
Y
N
S
I
R
R
-
G
-
G
A
C
V
L
V
G
L
P
P
E
-
E
M
P
I
P
I
F
-
D
-
T
V
L
---
N
G
-
I
K
I
I
G
S
I
V
G
---
T
-
R
---
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
T
---
I
I
E
V
Q
-
P
L
E
K
I
N
E
V
F
D
R
M
L
--
K
G
Q
---------