@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2257c: (2016-05-09 )
MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT
Atome Classification :
(20 SA)
-------------------------------------------------------.........10........20.....--...30---------....----------.-----....40........50........60....--------------------------.--------------------------.-------------------------..70-.........80-------.-.---.--------------------..---------------------------------.--------------------------------..-----------90.------------------------.......100.......110.......120.......130....--------------------...------------------------140------------------------------.-----------------------------------------------..-----------------------------------------------.---------------------------------....150.......160...-------.------...170------.......-.180------.......190.-.......-.200.......210------.-------------------..-.------------.-----.------..220.......---230-...---......240......--.250...---....260.......270--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------M
T
A
LEVLGGWPV
P
A
A
A
A
A
VIGP
A
G
VL--ATHG----------D
T
A
R
----------
V
-----
F
A
L
A
S
V
T
K
P
L
V
A
R
A
A
Q
V
A
V
EEG
V
V
NLDTPA--------------------------G--------------------------P-------------------------
P
G
S
--
T
V
R
H
L
L
A
HTSG-------L-A---M--------------------HS---------------------------------D--------------------------------
Q
A
-----------LAR------------------------PG
T
R
R
M
Y
SNY
G
F
T
V
L
A
E
S
V
Q
R
ESG
I
E
F
G
R
Y
L
T
E
A
V
CE
P
L
G
M
V
TT--------------------RLD------------------------GG-------------------------------P-----------------------------------------------AA-----------------------------------------------A---------------------------------GFGA
T
S
T
V
A
D
L
A
V
F
A
G
DLLR-------P------STV
S
A
-------
Q
MHAD
A
T
-
T
V
QF------PGLDGVLP--G-YGVQRPN-DWG
L
G
F
E
I
RNSKS-------P-------------------HW-T------------G-----E------CNSTRTFGHFGQ---S---G
G
F
---
I
W
VDPKA
D
L
A
L
V
V
L
T
--ARDFG
D
W
---
A
L
D
L
W
P
AI
S
D
A
V
LAEYT--
1
PsiBlast_PDB
79.38
98%
-41
- C2 -
3I7J
-
?
A:
[2-272]
--------------------------------------------------------
T
A
L
E
V
L
G
G
W
P
V
P
A
A
A
A
A
V
I
G
P
A
G
V
L
--
A
T
H
G
----------
D
T
A
R
----------
V
-----
F
A
L
A
S
V
T
K
P
L
V
A
R
A
A
Q
V
A
V
E
E
G
V
V
N
L
D
T
P
A
--------------------------
G
--------------------------
P
-------------------------
P
G
S
--
T
V
R
H
L
L
A
H
T
S
G
-------
L
-
A
---
M
--------------------
H
S
---------------------------------
D
--------------------------------
Q
A
-----------
L
A
R
------------------------
P
G
T
R
R
M
Y
S
N
Y
G
F
T
V
L
A
E
S
V
Q
R
E
S
G
I
E
F
G
R
Y
L
T
E
A
V
C
E
P
L
G
M
V
T
T
--------------------
R
L
D
------------------------
G
G
-------------------------------
P
-----------------------------------------------
A
A
-----------------------------------------------
A
---------------------------------
G
F
G
A
T
S
T
V
A
D
L
A
V
F
A
G
D
L
L
R
-------
P
------
S
T
V
S
A
-------
Q
M
H
A
D
A
T
-
T
V
Q
F
------
P
G
L
D
G
V
L
P
--
G
-
Y
G
V
Q
R
P
N
-
D
W
G
L
G
F
E
I
R
N
S
K
S
-------
P
-------------------
H
W
-
T
------------
G
-----
E
------
C
N
S
T
R
T
F
G
H
F
G
Q
---
S
---
G
G
F
---
I
W
V
D
P
K
A
D
L
A
L
V
V
L
T
--
A
R
D
F
G
D
W
---
A
L
D
L
W
P
A
I
S
D
A
V
L
A
E
Y
T
--
25
HHSearch
78.34
100%
-39
- C2 -
3I7J
-
?
A:
[2-269]
--------------------------------------------------------
T
A
L
E
V
L
G
G
W
P
V
P
A
A
A
A
A
V
I
G
P
A
G
V
L
--
A
T
H
G
----------
D
T
A
R
----------
V
-----
F
A
L
A
S
V
T
K
P
L
V
A
R
A
A
Q
V
A
V
E
E
G
V
V
N
L
D
T
P
A
--------------------------
G
--------------------------
P
-------------------------
P
G
S
--
T
V
R
H
L
L
A
H
T
S
G
-------
L
-
A
---
M
--------------------
H
S
---------------------------------
D
--------------------------------
Q
A
-----------
L
A
R
------------------------
P
G
T
R
R
M
Y
S
N
Y
G
F
T
V
L
A
E
S
V
Q
R
E
S
G
I
E
F
G
R
Y
L
T
E
A
V
C
E
P
L
G
M
V
T
T
--------------------
R
L
D
------------------------
G
G
-------------------------------
P
-----------------------------------------------
A
A
-----------------------------------------------
A
---------------------------------
G
F
G
A
T
S
T
V
A
D
L
A
V
F
A
G
D
L
L
R
-------
P
------
S
T
V
S
A
-------
Q
M
H
A
D
A
T
-
T
V
Q
F
------
P
G
L
D
G
V
L
P
--
G
-
Y
G
V
Q
R
P
N
-
D
W
G
L
G
F
E
I
R
N
S
K
S
-------
P
-------------------
H
W
-
T
------------
G
-----
E
------
C
N
S
T
R
T
F
G
H
F
G
Q
---
S
---
G
G
F
---
I
W
V
D
P
K
A
D
L
A
L
V
V
L
T
--
A
R
D
F
G
D
W
---
A
L
D
L
W
P
A
I
S
D
A
V
L
A
-----
33
HHSearch
73.19
22%
-94
- C2 -
4NET
4
?
A:
[17-346]
--------------------------------------------------------
N
F
K
P
L
L
E
K
Y
D
V
P
G
M
A
V
G
V
I
Q
N
N
K
K
Y
E
-
M
Y
Y
G
L
QSVQDKKAV
N
S
S
T
----------
I
-----
F
E
L
G
S
V
S
K
L
F
T
A
T
A
G
G
Y
A
K
N
K
G
K
I
S
F
D
D
T
P
--------------------------
G
KYW-----------------------
K
ELKNTPI------------------
D
Q
V
--
N
L
L
Q
L
A
T
Y
T
S
G
-------
N
-
L
---
A
--------------------
L
Q
---------------------------------
F
PDEVKT
D
Q
Q
V
L
T
F
F
K
D
W
---------------
K
P
-----------
K
N
S
------------------------
I
G
E
Y
R
Q
Y
S
N
P
S
I
G
L
F
G
K
V
V
A
L
S
M
N
K
P
F
D
Q
V
L
E
K
T
I
F
P
A
L
G
L
K
H
S
--------------------
Y
V
N
------------------------
V
P
KTQMQN
Y
A
F
G
Y
N
QEN
Q
P
I
R
V
N
P
GP-------
L
-----------------------------------------------
G
A
-----------------------------------------------
P
---------------------------------
A
Y
G
V
K
S
T
L
P
D
M
L
S
F
I
H
A
N
L
N
-------
P
------
Q
K
Y
P
A
-------
D
I
Q
R
A
I
N
-
E
T
H
Q
------
G
R
Y
-----------
Q
V
N
T
M
-
Y
Q
A
L
G
W
E
E
F
S
Y
P
A
-------
T
L
Q
T
L
L
D
S
N
SEQIVM
K
P
N
K
V
T
A
-
I
------------
S
-----
K
------
E
P
S
V
K
M
Y
H
K
T
G
-NR-
F
---
G
T
Y
---
V
V
F
I
P
K
E
N
I
G
L
V
M
L
T
--
N
K
R
I
P
N
E
----------------------
35
HHSearch
69.48
23%
-90
- C2 -
2FFY
2
AMPC_ECOLI
A:
[12-344]
--------------------------------------------------------
T
I
T
P
L
I
E
Q
Q
K
I
P
G
M
A
V
A
V
I
Y
Q
G
K
P
Y
Y
-
F
T
W
G
Y
ADIAKKQPV
T
Q
Q
T
----------
L
-----
F
E
L
G
S
V
S
K
T
F
T
G
V
L
G
G
D
A
I
A
R
G
E
I
K
L
S
D
P
T
--------------------------
T
K
Y
W
-----------------------
P
ELTAKQW------------------
N
G
I
--
T
L
L
H
L
A
T
Y
T
A
G
-------
G
-
L
---
P
--------------------
L
Q
---------------------------------
V
PDEVKS
S
S
D
L
L
R
F
Y
Q
N
W---------------
Q
P
-----------
A
W
A
------------------------
P
G
T
Q
R
L
Y
A
N
S
S
I
G
L
F
G
A
L
A
V
K
P
S
G
L
S
F
E
Q
A
M
Q
T
R
V
F
Q
P
L
K
L
N
H
T
--------------------
W
I
N
------------------------
V
P
PAEEKN
Y
A
W
G
Y
R
EG
K
A
V
H
V
SPGA--------
L
-----------------------------------------------
D
A
-----------------------------------------------
E
---------------------------------
A
Y
G
V
K
S
T
I
E
D
M
A
R
W
V
Q
S
N
L
K
-------
P
------
L
D
I
N
E
-------
K
T
L
Q
Q
G
I
-
Q
L
A
Q
------
S
R
Y
----------
W
Q
T
G
D
M
-
Y
Q
G
L
G
W
E
M
L
D
W
P
V
-------
N
P
D
S
I
I
N
G
S
DAKIALAA
R
--
P
V
-
K
------------
A
ITPPT
P
------
A
V
R
A
S
W
V
H
K
T
G
A
T
GG
F
---
G
S
Y
---
V
A
F
I
P
E
K
E
L
G
I
V
M
L
A
--
N
K
N
Y
P
N
P
----------------------
37
HHSearch
69.46
24%
-92
- C2 -
4WZ4
2
AMPC_PSEAE
A:
[13-359]
--------------------------------------------------------
A
V
Q
P
V
M
K
A
N
D
I
P
G
L
A
V
A
I
S
L
K
G
E
P
H
Y
-
F
S
Y
G
L
ASKEDG
R
R
V
T
P
E
T
----------
L
-----
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
--------------------------
S
QHW-----------------------
P
ALQGSRF------------------
D
G
I
--
S
L
L
D
L
A
T
Y
T
A
G
-------
G
L
P
---
L
--------------------
Q
F
---------------------------------
P
DSVQKD
Q
A
Q
I
R
D
Y
Y
R
Q
W---------------
Q
P
-----------
T
Y
A
------------------------
P
G
S
Q
R
L
Y
S
N
P
S
I
G
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--------------------
H
L
D
------------------------
V
P
EAALAQ
Y
A
Q
G
Y
G
K
DDRPLRVGPGP-------
L
-----------------------------------------------
D
A
-----------------------------------------------
E
---------------------------------
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
D
A
N
L
H
-------
P
------
E
R
L
D
R
-------
P
W
A
Q
A
L
D
-
A
T
H
R
------
G
Y
Y
-----------
K
V
G
D
M
-
T
Q
G
L
G
W
E
A
Y
D
W
P
I
-------
S
L
K
R
L
Q
A
G
N
S----------
T
P
M
A
L
Q
P
H
R
I
ARLPAP
Q
-----
A
------
L
E
G
Q
R
L
L
N
K
T
G
S
---
T
NG
F
G
A
Y
---
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
--
N
R
N
Y
P
N
A
------
E
R
V
K
I
A
Y
A
I
L
S
G
L
---
42
HHSearch
68.88
25%
-89
- C2 -
4IVK
4
?
A:
[51-424]
---------------------------------------------------------
L
K
N
E
I
Q
A
K
T
M
P
G
A
V
M
M
I
K
R
N
G
E
T
A
Y
F
S
S
F
G
LRDPDTK
E
P
M
T
A
E
T
----------
I
-----
F
R
I
Y
S
M
S
K
P
I
T
T
V
A
A
M
M
L
V
E
E
G
K
L
Q
L
D
E
P
V
--------------------------
S
KYI-----------------------
P
SFAN
V
K
V
G
V
E
T
K
G
EN
G
M
A
L
E
T
G
P
V
K
R
A
I
--
T
I
Q
D
L
M
R
H
T
S
G
-------
I
-
T
---
Y
--------------------
G
F
---------------------------------
V
GDG
L
V
K
K
A
Y
I
A
S
NLFDGDFD
N
A
E
F
A
E
R
I
A
K
L-
P
L
-----------
V
Y
Q
------------------------
P
G
T
T
W
D
Y
G
H
-
S
T
D
I
L
G
R
V
V
E
V
V
S
G
K
S
L
Y
Q
F
E
K
E
R
L
L
D
P
L
G
M
K
D
T
--------------------
G
F
Y
------------------------
V
T
-------------------------------
D
PAKKSL
V
A
E
A
MPNDRKIGGSEMFDPRVQKKW----------------
E
P
-----------------------------------------------
G
---------------------------------
G
Q
G
M
V
S
T
I
G
D
Y
A
R
F
T
Q
M
V
L
N
-------
G
GTLDGK
R
Y
L
S
P
-------
K
T
I
A
Y
M
G
-
S
N
H
I
------
P
Q
A
S
G
I
V
P
G
A
Y
-
Y
L
P
G
P
G
V
-
G
F
G
L
G
F
A
V
R
T
E
A
G
-------
V
-------------------
T
P
-
V
-------------------------
E
G
S
V
G
D
L
S
W
G
G
A
---
G
---
G
T
V
---
F
W
I
D
P
K
E
N
L
T
V
V
F
M
A
--
P
M
V
S
P
R
-----
A
R
V
W
R
T
L
R
N
I
V
Y
G
A
F
---
29
HHSearch
68.72
27%
-87
- C2 -
2QMI
-
?
A:
[10-332]
---------------------------------------------------------
I
V
E
K
M
A
E
R
K
V
P
G
I
S
I
S
I
I
K
D
G
D
V
V
Y
A
K
G
F
G
YRNVEAR
L
P
S
T
P
E
T
----------
I
-----
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
--------------------------
E
KFV-----------------------
N
IKLRPFG------------------
E
P
V
--
T
V
H
H
L
L
T
H
S
S
G
-------
I
-
P
---
S
--------------------
L
G
---------------------------------
Y
A
E
A
F
I
D
G
M
V
GGDNWLPVST
P
E
E
T
I
A
F
A
R
DMEK
W
A
-----------
V
A
K
------------------------
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
--------------------
Y
F
F
------------------------
K
E
E
V
E
K
DK
D
V
A
M
G
Y
I
L
D
KEG
R
L
V
P
Q
P
FPY----
G
-----------------------------------------------
I
T
-----------------------------------------------
A
---------------------------------
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
L
K
M
Y
I
E
-------
R
DE----
S
I
V
S
K
-------
E
Y
I
E
K
M
E
-
T
S
Y
I
------
K
V
P
W
---------
E
I
F
G
G
E
-
G
Y
G
Y
G
L
I
I
Y
P
N
F
----------------------------------------------------------
L
G
E
K
L
V
G
H
S
G
S
---
V
GM
Y
T
G
Y
---
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
--
N
S
S
G
Y
------------------------
44
HHSearch
68.04
25%
-85
- C2 -
4Y7P
3
?
A:
[62-373]
---------------------------------------------------------------
Q
L
G
F
P
G
I
L
A
K
T
S
E
G
G
K
T
W
S
-
Y
A
A
G
VANLSSKKPM
K
T
D
F
----------
R
-----
F
R
I
G
S
V
T
K
T
F
T
A
T
V
V
L
Q
L
A
E
E
N
R
L
N
L
D
D
S
I
--------------------------
E
KWL-----------------------
P
GVIQGNGYDD---------------
K
Q
I
--
T
I
R
Q
L
L
N
H
T
S
G
-------
I
-
A
---
E
--------------------
Y
T
---------------------------------
R
SKSFDLMDT
K
K
S
Y
R
A
E
E
L
V
K
M
G
I
SM-------
P
P
-----------
D
F
A
------------------------
P
G
K
S
W
S
Y
S
N
T
G
Y
V
L
L
G
I
L
I
E
T
V
T
G
N
S
Y
A
E
E
I
E
N
R
I
I
E
P
L
E
L
S
N
T
--------------------
F
L
P
------------------------
G
N
-------------------------------
S
SVIPGTKH
A
R
G
Y
I
Q
LDGASEPKDVTYYNPSM----------------
G
S
-----------------------------------------------
S
---------------------------------
A
G
D
M
I
S
T
A
D
D
L
N
K
F
F
S
Y
L
L
G
-------
G
------
K
L
L
K
E
-------
Q
Q
L
K
Q
M
L
-
T
T
V
P
------
T
G
------------
E
A
A
L
G
-
R
Y
G
L
G
I
Y
E
T
K
L
P
N
----------------------------------------------------------
G
V
S
I
W
G
H
G
G
S
---
I
PG
F
V
T
F
---
A
G
G
T
L
G
G
K
H
T
L
A
V
N
L
--
N
S
L
N
A
E
-----------------------
31
HHSearch
66.97
28%
-76
* C2 *
1CI9
1
ESTB_BURGA
A:
[25-391]
--------------------------------------------------------
V
F
D
Q
A
L
R
E
R
R
L
V
G
A
V
A
I
V
A
R
H
G
E
I
L
Y
R
R
A
Q
G
LADREAG
R
P
M
R
E
D
T
----------
L
-----
F
R
L
A
S
V
T
K
P
I
V
A
L
A
V
L
R
L
V
A
R
G
E
L
A
L
D
A
P
V
--------------------------
T
RWL-----------------------
P
EF
R
P
R
L
ADGSE--------------
P
L
V
--
T
I
H
H
L
L
T
H
T
S
G
-------
L
-
G
---
Y
--------------------
W
L
LEGAGS
V
Y
D
R
L
GISDGIDLRDFD
L
D
E
N
L
R
R
L
A
S
A
--------------------------------
P
L
-----------
S
F
A
------------------------
P
G
S
G
W
Q
Y
S
L
-
A
L
D
V
L
G
A
V
V
E
R
A
T
G
Q
P
L
A
A
A
V
D
A
L
V
A
Q
P
L
G
M
R
D
C
--------------------
G
F
V
------------------------
S
A
-------------------------------
E
PERFA
V
P
Y
H
D
GQP
E
P
V
R
M
R
D
G
I
E
V
P
L
P
EGHGA
A
V
R
F
A
PSRVFEPGAY
P
S
-----------------------------------------------
G
---------------------------------
G
A
G
M
Y
G
S
A
D
D
V
L
R
A
L
E
A
I
R
A
-------
N
------
P
G
F
L
P
-------
E
T
L
A
D
A
A
R
R
D
Q
A
------
G
V
G
A
----------
E
T
R
G
P
-
G
W
G
F
G
Y
L
S
A
V
L
D
D
-------
P
-------------------
A
A
-
A
------------
G
-----
T
------
P
Q
H
A
G
T
L
Q
W
G
G
V
---
Y
---
G
H
S
---
W
F
V
D
R
A
L
G
L
S
V
L
L
L
T
--
N
T
A
Y
E
G
M
---
S
G
P
L
T
I
A
L
R
D
A
V
Y
A
-----
47
Fugue
66.55
28%
-86
- C2 -
1CI9
1
ESTB_BURGA
A:
[15-391]
--------------------------------------------A
A
S
L
A
A
R
L
D
A
V
F
D
Q
A
L
R
E
R
R
L
V
G
A
V
A
I
V
A
R
H
G
E
I
L
Y
R
--
R
A
Q
G
----------
L
A
D
R
EAG
R
P
M
R
EDT
L
-----
F
R
L
A
S
V
T
K
P
I
V
A
L
A
V
L
R
L
V
A
R
G
E
L
A
L
D
A
P
V
--------------------------
T
RWLPEF
R
P
R
L
ADGS------------
E
-------------------------
P
L
V
--
T
I
H
H
L
L
T
H
T
S
G
-------
L
-
G
---
Y
--------------------
W
L
---------------------------------
L
EGAGS
V
Y
D
R
L
GISDGIDLRDFD
L
D
E
N
L
-----
R
R
-----------
L
A
S
APLSFA------------------
P
G
S
G
W
Q
Y
S
-
L
A
L
D
V
L
G
A
V
V
E
R
A
T
G
Q
P
L
A
A
A
V
D
A
L
V
A
Q
P
L
G
M
R
D
C
--------------------
G
F
V
------------------------
S
A
-------------------------------
E
-----------------------------------------------
P
E
RFA
V
P
Y
H
D
GQP
E
P
V
R
M
R
D
G
I
E
V
P
L
P
EGHGA
A
V
R
F
A
PSRVFEPGAYPS
G
---------------------------------
G
A
G
M
Y
G
S
A
D
D
V
L
R
A
L
E
A
I
R
A
-------
N
------
P
G
F
L
P
-------
E
T
L
A
D
A
A
-
R
R
D
Q
------
A
G
V
G
A
E
T
R
--
G
-
P
G
-------
W
G
F
G
Y
L
S
A
V
L
D
D
-------
P
-------------------
A
A
-
A
------------
G
-----
T
------
P
Q
H
A
G
T
L
Q
W
G
G
V
---
Y
---
G
H
S
---
W
F
V
D
R
A
L
G
L
S
V
L
L
L
T
--
N
T
A
Y
E
G
M
---
S
G
P
L
T
I
A
L
R
D
A
V
Y
A
-----
39
HHSearch
66.23
24%
-87
- C2 -
3TG9
-
?
A:
[4-318]
--------------------------------------------------------
H
L
H
T
I
M
E
D
W
K
L
S
G
T
A
L
-
M
K
K
G
E
D
I
P
F
I
A
S
L
G
F
ANRAER
I
P
N
E
H
H
T
----------
R
-----
F
G
I
A
S
G
C
K
L
F
T
A
I
A
I
C
Q
L
V
E
A
G
K
L
S
F
D
T
P
L
--------------------------
S
DWL-----------------------
D
APF----------------------
P
N
V
--
T
I
H
H
L
L
T
H
T
S
G
-------
V
-
P
---
D
--------------------
Y
F
---------------------------------
D
EDLWKDVPMYHLRRLKDFLPLFQHA-------
P
M
-----------
K
F
P
------------------------
P
G
H
R
F
H
Y
N
N
A
G
F
I
L
L
G
L
V
V
E
S
V
S
G
V
T
F
Q
E
Y
V
E
A
N
V
F
Q
R
A
G
M
H
E
S
--------------------
G
Y
F
------------------------
A
F
DTLPAK
T
A
L
G
Y
I
D
L
EDG
S
W
K
T
NLYSLPV---
I
-----------------------------------------------
G
G
-----------------------------------------------
S
---------------------------------
D
G
G
A
Y
V
T
A
E
D
M
M
K
L
W
L
A
L
M
R
-------
H
------
E
L
L
N
E
-------
T
Y
T
Q
K
L
L
-
T
P
H
V
------
H
C
-------------
E
D
D
D
-
Y
Y
G
Y
G
V
W
I
K
Q
Q
D
G
----------------------------------------------------------
A
I
S
K
Y
H
V
M
G
Y
D
PG
V
---
C
F
H
---
S
A
F
Y
P
T
S
N
G
I
V
V
V
C
A
--
N
Q
S
S
G
A
-----------------------
34
HHSearch
66.03
21%
-90
- C2 -
4E6W
4
?
A:
[6-332]
--------------------------------------------------------
L
I
H
Q
R
M
Q
E
A
K
V
P
A
L
S
V
S
V
T
I
K
G
V
R
Q
R
-
F
V
Y
G
V
ADVASQKAN
T
L
D
T
----------
V
-----
Y
E
L
G
S
M
S
K
A
F
T
G
L
V
V
Q
I
L
I
Q
E
G
R
L
R
Q
G
D
D
I
--------------------------
I
TYL-----------------------
P
E
M
R
L
N
Y
QG
K
P
---------------
A
S
L
--
T
V
A
D
F
L
Y
H
T
S
G
-------
L
-
P
---
F
--------------------
S
T
---------------------------------
L
A
R
L
EA
V
A
Q
Q
L
RNE-------------------
N
L
-----------
L
F
A
------------------------
P
G
A
K
F
S
Y
A
S
A
N
Y
D
V
L
G
A
V
I
E
N
V
T
G
K
T
F
T
E
V
I
A
E
R
L
T
Q
P
L
G
M
S
A
T
--------------------
V
A
V
------------------------
K
G
D
E
I
I
V
NK
A
S
G
Y
K
L
G
FGKPVLFH
A
P
L
A
R----
N
-----------------------------------------------
H
V
-----------------------------------------------
P
---------------------------------
A
A
Y
I
H
S
T
L
P
D
M
E
I
W
I
D
A
W
L
H
-------
R
------
K
A
L
P
A
-------
T
L
R
E
A
M
S
-
N
S
W
R
------
G
N
S
D
V
-----
P
-
L
A
A
D
N
R
I
-
L
Y
A
S
G
W
F
I
D
Q
N
------------------------------------------------------------
Q
G
P
Y
I
S
H
G
G
Q
---
N
PN
F
S
S
C
---
I
A
L
R
P
D
Q
Q
I
G
I
V
A
L
A
--
N
M
N
S
N
L
----
I
L
Q
L
C
A
D
I
D
N
Y
L
R
I
-----
8
PsiBlast_PDB
65.29
22%
-87
- C2 -
4IVK
3
?
A:
[95-402]
---------------------------------------------------------------------------------------------------------------
I
-----
F
R
I
Y
S
M
S
K
P
I
T
T
V
A
A
M
M
L
V
E
E
G
K
L
Q
L
D
E
P
V
SKYIPSFAN
V
K
V
G
V
E
T
K
G
EN
G
M
A
L
E
T
G
--------------------------
P
-------------------------
V
K
R
AI
T
I
Q
D
L
M
R
H
T
S
G
-------
I
-
T
---
Y
GFVGDG
L
V
K
K
A
Y
I
A
S
NLFDG
D
F
---------------------------------
D
--------------------------------
N
A
E
F
A
E
R
I
A
K
LPL
V
Y
Q
------------------------
P
G
T
T
W
D
Y
-
G
H
S
T
D
I
L
G
R
V
V
E
V
V
S
G
K
S
L
Y
Q
F
E
K
E
R
L
L
D
P
L
G
M
K
D
T
GFYVTDPAKKSL
V
A
E
A
MPND
R
K
I
------------------------
G
G
-------------------------------
S
-----------------------------------------------
E
M
FDPRVQKKWEP------------------------------------
G
---------------------------------
G
Q
G
M
V
S
T
I
G
D
Y
A
R
F
T
Q
M
V
L
N
-------
G
------
G
T
L
D
G
-------
K
R
Y
L
S
P
K
-
T
I
A
Y
M
G
SNHI
P
Q
A
S
G
I
V
P
--
G
A
Y
Y
L
P
G
P
G
V
G
F
G
L
G
F
A
V
R
T
E
A
G
-------
V
-------------------
T
P
-
V
------------
E
-----
G
------
S
V
G
D
L
S
W
G
--
G
A
---
G
---
G
T
V
---
F
W
I
D
P
K
E
N
L
T
V
V
F
M
--------------------------------
36
HHSearch
64.11
22%
-85
- C2 -
1YQS
4
DAC_STRSR
A:
[16-343]
----------------------------------------------------------
H
T
A
L
S
-
Q
G
A
P
G
A
M
V
R
V
D
D
N
G
T
I
H
Q
-
L
S
E
G
VADRATG
R
A
I
T
T
T
D
----------
R
-----
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
--------------------------
N
T
Y
L
-----------------------
P
GLLPD--------------------
D
R
I
--
T
V
R
Q
V
M
S
H
R
S
G
-------
L
-
Y
---
D
--------------------
Y
T
---------------------------------
N
D
M
F
A
QT
V
P
G
F
E
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
L
KH--
G
V
-----------
T
N
A
------------------------
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
--------------------
F
Y
V
------------------------
H
P
DTVIP
G
T
H
A
N
G
Y
L
T
P
DEAGGALVDSTEQTVS
W
-----------------------------------------------
A
Q
-----------------------------------------------
S
---------------------------------
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
F
S
A
L
M
S
-------
G
------
Q
L
M
S
A
-------
A
Q
L
A
Q
M
Q
-
Q
W
T
T
------
V
N
--------------
S
T
Q
-
G
Y
G
L
G
L
R
R
R
D
L
S
C
----------------------------------------------------------
G
I
S
V
Y
G
H
T
G
T
---
V
QG
Y
Y
T
Y
---
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
--
N
T
S
N
N
V
N
V
--
L
N
T
M
A
R
T
L
E
S
A
F
-------
41
HHSearch
63.47
25%
-84
- C2 -
2DRW
4
?
A:
[18-358]
----------------------------------------------------------------
R
G
V
V
G
V
S
L
A
L
C
L
P
G
E
E
T
S
L
Y
Q
S
G
YADKFNK
M
P
M
T
G
D
H
----------
L
-----
F
R
I
A
S
C
T
K
S
F
I
A
T
G
L
H
L
L
V
Q
D
G
T
V
D
L
D
E
P
I
--------------------------
T
RWF-----------------------
P
DLPKA--------------------
A
Q
M
--
P
V
R
I
L
L
N
H
R
S
G
-------
L
-
P
---
D
--------------------
F
E
---------------------------------
T
SMPMISD
K
S
W
T
A
Q
E
I
V
D
F
S
F
R
H----------
G
V
-----------
Q
K
E
------------------------
P
W
H
G
M
E
Y
S
N
T
G
Y
V
L
A
G
M
I
I
A
H
E
T
G
K
P
Y
S
D
H
L
R
S
R
I
F
A
P
L
G
M
K
D
T
--------------------
W
V
G
------------------------
T
H
-------------------------------
E
TFPIEREA
R
G
Y
M
H
AAADDENPQWDVSGAGDPVDGVWDSTEWFPLSG-
A
N
-----------------------------------------------
A
---------------------------------
A
G
D
M
V
S
T
P
R
D
I
V
K
F
L
N
A
L
F
D
-------
G
------
R
I
L
D
Q
-------
K
R
L
W
E
M
K
-
D
N
I
K
------
P
A
F
F
P
---------
G
S
N
T
V
-
A
N
G
H
G
L
L
L
M
R
Y
G
-----------------------------------------------------------
S
S
E
L
K
G
H
L
G
Q
---
I
PG
H
T
S
I
---
M
G
R
D
E
E
T
G
A
A
L
M
L
I
Q
--
N
S
G
A
G
D
F
ESF
Y
L
K
G
V
N
E
P
V
D
R
V
L
E
A
I
---
53
Fugue
62.22
22%
-89
- C2 -
3HLF
1
LOVD_ASPTE
A:
[8-432]
HHSSGLVPRGSH
M
G
S
I
I
D
AAAAAG
P
V
V
L
M
E
T
A
F
R
K
A
V
E
S
RQIP
G
A
V
I
M
A
R
D
ASGN
L
N
Y
T
R
C
F
G
A
R
T
V
R
R
D
E
N
N
Q
L
P
P
L
-------------------
Q
V
D
T
----------
P
-----
C
R
L
A
A
A
T
K
L
L
T
T
I
M
V
L
Q
C
M
E
R
G
L
V
D
L
D
E
T
V
--------------------------
D
RLL
P
D
L
S
A
M
P
V
L
EGFDDAG
N
A
R
L
R
E
R
R
-------------------------
G
K
I
--
T
L
R
H
L
L
T
H
T
S
G
-------
L
-
S
YVF
L
--------------------
H
P
---------------------------------
L
--------------------------------
L
R
-----------
E
Y
M
A
Q
GYLQSAEKFGIQSRLAPPAVND
P
G
A
E
W
I
Y
G
-
T
N
L
D
W
A
G
K
L
V
E
R
A
T
G
L
D
L
E
Q
Y
L
Q
E
N
I
C
A
P
L
G
I
T
D
M
TF------------------
K
L
Q
------------------------
Q
R
-------------------------------
P
-----------------------------------------------
D
M
-----------------------------------------------
L
A
R
R
A
D
Q
T
H
R
N
SADG
R
L
R
Y
D
DSVYFRADGEECFG
G
Q
G
V
F
S
S
P
G
S
Y
M
K
V
L
H
S
L
L
K
RDGLLLQ
P
------
Q
T
V
D
L
M
F
QPALE
P
R
L
E
E
Q
M
-
N
Q
H
M
------
D
A
S
P
H
I
N
Y
--
G
-
G
P
M
P
M
V
L
-
R
R
S
F
G
L
G
G
I
I
A
L
E
-------
D
-------------------
L
D
-
G
------------
E
-----
N
------
W
R
R
K
G
S
L
T
F
G
G
G
---
P
---
N
I
V
---
W
Q
I
D
P
K
A
G
L
C
T
L
A
F
F
QL
E
P
W
N
D
P
V
---
C
R
D
L
T
R
T
F
E
H
A
I
Y
A
Q
Y
Q
QG
38
HHSearch
61.93
22%
-85
- C2 -
4GDN
-
FLP_STAAN
A:
[19-329]
---------------------------------------------------------
I
E
H
D
L
Q
K
G
H
I
P
G
A
S
I
L
I
V
K
N
G
K
V
F
L
N
K
G
Y
G
YQDVDKK
V
K
A
S
P
T
T
----------
K
-----
Y
E
I
A
S
N
T
K
A
F
T
G
L
A
I
L
K
L
A
Q
E
G
R
L
N
L
N
D
D
V
--------------------------
S
K
H
V
-----------------------
P
HF
K
M
N
Y
NG
Q
N
---------------
E
T
I
--
T
I
K
Q
L
L
A
Q
T
S
G
-------
I
-
P
---
S
--------------------
D
I
---------------------------------
T
SEDAVTNKNNRLNDV
T
R
A
I
M
GD----------
E
L
-----------
H
H
K
------------------------
P
G
E
E
F
E
Y
S
N
M
N
Y
D
L
L
G
L
I
I
Q
N
V
T
K
Q
S
Y
T
K
Y
I
T
N
S
W
L
K
P
L
H
M
T
H
T
--------------------
S
F
K
------------------------
Q
T
-------------------------------
N
NKSKH
D
A
I
G
Y
E
L
QGSTPVVSKPEFNLW--------------------
D
T
-----------------------------------------------
P
---------------------------------
S
A
Y
M
M
T
S
T
E
D
L
E
H
W
I
K
F
Q
L
N
-------
P
------
P
D
K
Y
K
-------
S
L
V
Q
Q
S
H
-
K
N
L
S
------
S
T
I
----------
G
E
P
N
A
N
-
A
Y
A
S
G
W
F
T
N
N
-------------------------------------------------------------
D
E
H
L
V
F
H
S
G
T
L
DN
F
---
S
S
F
---
I
L
L
N
P
K
Q
N
Y
G
I
V
V
L
A
--
N
L
N
S
E
Y
-----------------------
12
PsiBlast_PDB
61.88
22%
-79
- C2 -
4OOY
1
AMPC_PSEAE
A:
[43-343]
--------------------------------------------------------------------------------
L
--
A
S
K
E
----------
D
G
R
R
----------
V
T
PE
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
--------------------------
S
--------------------------
Q
HWPALQGSRF---------------
D
G
I
--
S
L
L
D
L
A
T
Y
T
A
G
GLPLQFP
D
-
S
---
V
--------------------
Q
K
---------------------------------
D
--------------------------------
Q
A
-----------
Q
I
R
D
Y
Y
R
Q
WQPTYA-------------
P
G
S
Q
R
L
Y
S
N
P
S
I
G
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--------------------
H
L
D
VPEAALAQ
Y
A
Q
G
Y
G
K
DDRPLRVGP
G
P
-------------------------------
L
-----------------------------------------------
D
A
-----------------------------------------------
E
---------------------------------
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
D
A
N
L
H
-------
P
------
E
R
L
D
R
P
W
-----
A
Q
A
L
D
A
T
-
H
R
G
Y
------
Y
K
V
G
D
M
T
Q
--
G
-
L
G
W
E
-
A
Y
-
D
W
P
I
S
L
K
R
L
Q
A
G
N
S
T
P
M
A
L
Q
P
-------------------
H
R
-
I
------------
A
-----
R
LPAPQA
L
E
G
Q
R
L
L
N
K
T
G
S
---
T
---
N
G
F
G
A
Y
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
--
N
R
N
Y
-------------------------
20
PsiBlast_PDB
61.45
22%
-78
- C2 -
4NK3
1
AMPC_PSEAE
A:
[49-349]
--------------------------------------------------------------------------------
L
--
A
S
K
E
----------
D
G
R
R
----------
V
T
PE
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
--------------------------
S
--------------------------
Q
HWPALQGSRF---------------
D
G
I
--
S
L
L
D
L
A
T
Y
T
A
G
GLPLQFP
D
-
S
---
V
--------------------
Q
K
---------------------------------
D
--------------------------------
Q
A
-----------
Q
I
R
D
Y
Y
R
Q
WQPTYA-------------
P
G
S
Q
R
L
Y
S
N
P
S
I
G
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--------------------
H
L
D
VPEAALAQ
Y
A
Q
G
Y
G
K
DDRPLRVGP
G
P
-------------------------------
L
-----------------------------------------------
D
A
-----------------------------------------------
E
---------------------------------
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
D
A
N
L
H
-------
P
------
E
R
L
D
R
P
W
-----
A
Q
A
L
D
A
T
-
H
R
G
Y
------
Y
K
V
G
D
M
T
Q
--
G
-
L
G
W
E
-
A
Y
-
D
W
P
I
S
L
K
R
L
Q
A
G
N
S
T
P
M
A
L
Q
P
-------------------
H
R
-
I
------------
A
-----
R
LPAPQA
L
E
G
Q
R
L
L
N
K
T
G
S
---
T
---
N
G
F
G
A
Y
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
--
N
R
N
Y
-------------------------
16
PsiBlast_PDB
61.13
22%
-79
- C2 -
4HEF
3
AMPC_PSEAE
A:
[43-343]
--------------------------------------------------------------------------------
L
--
A
S
K
E
----------
D
G
R
R
----------
V
T
PE
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
--------------------------
S
--------------------------
Q
HWPALQGSRF---------------
D
G
I
--
S
L
L
D
L
A
T
Y
T
A
G
GLPLQFP
D
-
S
---
V
--------------------
Q
K
---------------------------------
D
--------------------------------
Q
A
-----------
Q
I
R
D
Y
Y
R
Q
WQPTYA-------------
P
G
S
Q
R
L
Y
S
N
P
S
I
G
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--------------------
H
L
D
VPEAALAQ
Y
A
Q
G
Y
G
K
RDRPLRVGP
G
P
-------------------------------
L
-----------------------------------------------
D
A
-----------------------------------------------
E
---------------------------------
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
D
A
N
L
H
-------
P
------
E
R
L
D
R
P
W
-----
A
Q
A
L
D
A
T
-
H
R
G
Y
------
Y
K
V
G
D
M
T
Q
--
G
-
L
G
W
E
-
A
Y
-
D
W
P
I
S
L
K
R
L
Q
A
G
N
S
T
P
M
A
L
Q
P
-------------------
H
R
-
I
------------
A
-----
R
LPAPQA
L
E
G
Q
R
L
L
N
K
T
G
S
---
T
---
N
G
F
G
A
Y
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
--
N
R
N
Y
-------------------------