@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2372c: (2016-05-10 )
MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDGVGRLARCVVEQAGRGGLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGADAFLAWQAARCVANWDGARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVREEVAAGAAVLVLHEEATERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRLGPTVLRTSTAAAVALGAVGVLTSRWDASASDCEYCDVTRR
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------.........10........20........30........40.........50........60......-.-.-70-.-..---.....-.80.--....-.-..90-........100.......110.......120.......130.......140-.......150.......160......--.170.......180-.....-----..-.190---------........200.----......210.......220.......230.....-..240.......250-.......260-----------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------
M
V
A
M
L
F
Y
VDTLPDTG
A
V
A
V
V
DGDEGFH
A
A
T
V
R
RIRPG
E
Q
L
-
V
LGD
G
V
G
R
L
A
R
C
V
V
E
QAGRG
G
L
R
A
R
V
L
-
R
-R-W--S-VP---PVRP
P
-
V
T
V
V
--
Q
ALP-
K
-
S
ERS-
E
L
A
I
E
L
ATEAGA
D
A
F
L
A
W
Q
A
A
R
C
VANWD
G
A
R
V
D
K
G
L
R
R
W
R
A
V
V
R
S
A
A
R
QSR-RARIPPVDGVLS
T
P
M
L
V
Q
R
V
R
E
E
VAA--G
A
A
V
L
V
L
H
E
E
A
T
-
E
-
R
I
V
D
I
-----
A
A-AQ-A---------G
S
L
M
L
V
VGPEGG----I
A
P
D
E
L
A
A
LTDA
G
A
V
A
V
RLGP
T
V
LRTS
T
A
A
A
V
A
L
-
G
A
V
G
V
LTSRWDASAS-DCEYCDVTRR-----------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
99.78
100%
-133
- C5 -
4L69
-
RSME_MYCTU
A:
[2-248]
---------------------------------------------------------------------------------------------------------
V
A
M
L
F
Y
V
D
T
L
P
D
T
G
A
V
A
V
V
D
G
D
E
G
F
H
A
A
T
V
R
R
I
R
P
G
E
Q
L
-
V
L
G
D
G
V
G
R
L
A
R
C
V
V
E
Q
---
G
G
L
R
A
R
V
L
-
R
-
R
-
W
--
S
-
V
P
---
P
V
R
P
P
-
V
T
V
V
--
Q
A
L
P
-
K
-
S
E
R
S
-
E
L
A
I
E
L
A
T
E
A
G
A
D
A
F
L
A
W
Q
A
A
R
C
V
A
N
W
D
G
A
R
V
D
K
G
L
R
R
W
R
A
V
V
R
S
A
A
R
Q
S
R
-
R
A
R
I
P
P
V
D
G
V
L
S
T
P
M
L
V
Q
R
V
R
E
E
V
A
A
--
G
A
A
V
L
V
L
H
E
E
A
T
-
E
-
R
I
V
D
I
-----
A
A
-
A
Q
-
A
---------
G
S
L
M
L
V
V
G
P
E
G
G
----
I
A
P
D
E
L
A
A
L
T
D
A
G
A
V
A
V
R
L
G
P
T
V
L
R
T
S
T
A
A
A
V
A
L
-
G
A
V
G
V
L
T
S
R
W
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.68
100%
-133
- C5 -
4L69
-
RSME_MYCTU
A:
[2-248]
---------------------------------------------------------------------------------------------------------
V
A
M
L
F
Y
V
D
T
L
P
D
T
G
A
V
A
V
V
D
G
D
E
G
F
H
A
A
T
V
R
R
I
R
P
G
E
Q
L
-
V
L
G
D
G
V
G
R
L
A
R
C
V
V
E
Q
---
G
G
L
R
A
R
V
L
-
R
-
R
-
W
--
S
-
V
P
---
P
V
R
P
P
-
V
T
V
V
--
Q
A
L
P
-
K
-
S
E
R
S
-
E
L
A
I
E
L
A
T
E
A
G
A
D
A
F
L
A
W
Q
A
A
R
C
V
A
N
W
D
G
A
R
V
D
K
G
L
R
R
W
R
A
V
V
R
S
A
A
R
Q
S
R
-
R
A
R
I
P
P
V
D
G
V
L
S
T
P
M
L
V
Q
R
V
R
E
E
V
A
A
--
G
A
A
V
L
V
L
H
E
E
A
T
-
E
-
R
I
V
D
I
-----
A
A
-
A
Q
-
A
---------
G
S
L
M
L
V
V
G
P
E
G
G
----
I
A
P
D
E
L
A
A
L
T
D
A
G
A
V
A
V
R
L
G
P
T
V
L
R
T
S
T
A
A
A
V
A
L
-
G
A
V
G
V
L
T
S
R
W
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.53
25%
-104
- C5 -
4E8B
-
RSME_ECOLI
A:
[6-237]
------------------------------------------------------------------------------------------------------------
I
Y
H
P
E
P
L
T
S
H
S
H
I
A
L
C
E
-
D
A
A
N
H
I
G
R
V
L
R
M
G
P
G
Q
A
L
-
Q
L
F
D
G
S
N
Q
V
F
D
A
E
I
T
S
A
S
K
K
S
V
E
V
K
V
L
-
E
---
G
--
Q
-
I
D
---
D
R
E
S
P
-
L
H
I
H
L
G
Q
V
M
S
-
R
-
G
E
K
M
-
E
F
T
I
Q
K
S
I
E
L
G
V
S
L
I
T
P
L
F
S
E
R
C
G
V
K
L
D
S
E
R
L
N
K
K
L
Q
Q
W
Q
K
I
A
I
A
A
C
E
Q
C
G
-
R
N
R
V
P
E
I
R
P
A
M
D
L
E
A
W
C
A
E
Q
D
E
G
L
K
-------
L
N
L
H
P
R
A
S
-
N
-
S
I
-
N
T
-----
L
P
-
L
P
-
V
---------
E
R
V
R
L
L
I
G
P
E
G
G
----
L
S
A
D
E
I
A
M
T
A
R
Y
Q
F
T
D
I
L
L
G
P
R
V
L
R
T
E
T
T
A
L
T
A
I
-
T
A
L
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
71.49
24%
-102
- C5 -
4E8B
-
RSME_ECOLI
A:
[5-244]
------------------------------------------------------------------------------------------------------------
R
I
Y
H
P
E
P
L
T
S
H
S
H
I
A
L
C
E
D
A
A
N
H
I
G
R
V
L
R
M
G
P
G
Q
A
L
-
Q
L
F
D
G
S
N
Q
V
F
D
A
E
I
T
S
A
S
K
K
S
V
E
V
K
V
L
-
E
-
G
Q
I
--
D
-
D
R
---
E
S
P
L
H
-
I
H
L
G
--
Q
V
M
S
-
R
-
G
E
K
M
-
E
F
T
I
Q
K
S
I
E
L
G
V
S
L
I
T
P
L
F
S
E
R
C
G
V
K
L
D
S
E
R
L
N
K
K
L
Q
Q
W
Q
K
I
A
I
A
A
C
E
Q
C
G
-
R
N
R
V
P
E
I
R
P
A
M
D
L
E
A
W
C
A
E
Q
D
-------
E
G
L
K
L
N
L
H
P
R
A
S
-
N
-
S
I
N
T
L
------
P
-
L
P
-
V
---------
E
R
V
R
L
L
I
G
P
E
G
G
----
L
S
A
D
E
I
A
M
T
A
R
Y
Q
F
T
D
I
L
L
G
P
R
V
L
R
T
E
T
T
A
L
T
A
I
-
T
A
L
Q
V
R
F
G
D
L
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.39
27%
-104
- C5 -
3KW2
1
?
A:
[7-242]
------------------------------------------------------------------------------------------------------------
L
F
Y
A
---
P
D
I
E
Q
S
D
R
L
P
D
D
E
A
G
H
I
L
R
V
L
R
M
Q
A
G
D
R
L
-
R
L
T
D
G
R
G
S
F
F
D
A
V
I
E
T
A
D
R
K
S
C
Y
V
S
V
C
-
G
-
Q
-
E
--
S
W
Q
K
---
P
W
R
D
R
-
I
T
I
A
--
I
A
P
T
-
K
Q
S
E
R
M
-
E
W
M
L
E
K
L
V
E
I
G
V
D
E
V
V
------
F
I
E
S
E
H
S
E
R
R
R
I
K
A
E
R
L
E
R
I
A
I
S
A
M
K
Q
S
L
-
K
A
S
F
P
----
V
I
R
V
N
I
P
I
Q
T
V
I
A
D
T
P
K
--
A
A
V
R
L
I
A
Y
V
D
E
A
-
V
-
R
------------
G
R
-
G
YPSDFYHVG
Q
D
V
L
I
L
I
G
P
E
G
D
----
F
S
P
S
E
V
E
S
A
L
L
A
G
F
A
P
V
S
L
G
E
S
R
L
R
T
E
T
A
G
L
V
A
C
-
Q
W
I
H
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
68.57
23%
-113
- C5 -
2EGV
2
RSME_AQUAE
A:
[3-229]
------------------------------------------------------------------------------------------------------------
V
F
Y
S
E
E
R
--
R
G
N
L
L
I
L
R
E
G
E
V
K
H
F
-
R
V
R
R
I
E
K
D
E
E
F
-
G
V
I
H
-
E
G
K
I
Y
V
C
K
V
R
R
E
D
K
R
E
I
S
C
E
I
V
-
E
-
E
-
L
--
E
-
T
K
---
L
P
P
K
D
-
I
T
L
Y
--
Q
S
V
T
V
D
-
L
K
T
M
-
D
T
I
V
R
Q
A
T
E
L
G
V
L
T
F
V
P
I
I
S
E
R
S
F
Q
K
E
E
--
A
I
L
K
K
T
E
K
W
K
R
I
V
I
E
A
M
K
Q
S
R
-
R
P
I
P
M
E
I
K
K
P
V
R
L
S
D
L
I
P
E
S
E
--------
E
-
N
I
I
L
D
N
F
Y
E
G
V
-
K
P
K
D
V
------
N
-
L
E
-
A
---------
K
T
Y
S
V
V
V
G
P
E
G
G
----
F
S
K
R
E
S
Q
I
L
R
E
K
G
F
K
S
V
L
L
E
P
Y
T
L
R
T
E
T
A
V
V
S
I
V
-
S
I
L
M
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
68.12
26%
-101
- C5 -
3KW2
1
?
A:
[6-248]
-----------------------------------------------------------------------------------------------------------
P
L
F
Y
A
P
D
---
I
E
Q
S
D
R
L
P
D
D
E
A
G
H
I
L
R
V
L
R
M
Q
A
G
D
R
L
-
R
L
T
D
G
R
G
S
F
F
D
A
V
I
E
T
A
D
R
K
S
C
Y
V
S
V
C
-
G
Q
E
-
S
--
W
-
Q
K
---
P
W
R
D
R
-
I
T
I
A
--
I
A
P
T
K
Q
-
S
E
R
M
-
E
W
M
L
E
K
L
V
E
I
G
V
D
E
V
V
F
I
E
S
E
H
S
E
R
R
R
------
I
K
A
E
R
L
E
R
I
A
I
S
A
M
K
Q
S
L
-
K
A
S
F
P
V
I
R
V
N
I
P
I
Q
T
V
I
A
D
T
P
K
------
A
A
V
R
L
I
A
Y
V
D
E
A
-
V
R----
G
RGYPS
D
F
Y
H
V
-
G
---------
Q
D
V
L
I
L
I
G
P
E
G
D
----
F
S
P
S
E
V
E
S
A
L
L
A
G
F
A
P
V
S
L
G
E
S
R
L
R
T
E
T
A
G
L
V
A
C
-
Q
W
I
H
T
L
Q
A
C
Y
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
63.20
27%
-91
- C5 -
1Z85
3
?
A:
[22-232]
---------------------------------------------------------------------------------------------------------------------
Q
N
G
E
V
I
F
D
E
R
E
A
H
H
M
-
R
V
V
R
L
K
E
G
D
V
I
-
E
A
T
D
G
N
G
F
S
Y
T
C
I
L
K
S
L
K
K
K
T
A
A
A
K
I
V
-
K
V
E
-
E
--
K
-
E
K
---
E
P
T
E
K
-
L
S
V
V
--
V
P
I
G
-
R
-
W
E
R
T
-
R
F
L
I
E
K
C
V
E
L
G
V
D
E
I
F
F
H
K
F
E
R
S
Q
H
E
-------
I
S
L
D
K
A
K
I
V
V
R
E
A
A
K
Q
C
K
-
R
Y
L
F
P
K
V
S
F
L
E
K
L
E
F
----
S
---------
G
N
V
I
T
L
D
L
----
Q
-
N
L
L
D
-------
A
-
N
L
-
E
---------
G
S
I
T
V
V
V
G
P
E
G
G
----
F
S
E
K
E
R
E
L
L
R
S
S
T
-
T
I
V
------
L
R
F
E
T
A
A
I
L
T
V
-
G
Y
I
A
L
K
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.17
33%
-74
- C5 -
2Z0Y
1
?
A:
[10-213]
----------------------------------------------------------------------------------------------------------------------
G
L
T
G
V
L
P
L
R
E
T
R
H
L
V
E
V
L
R
A
R
V
G
D
R
F
-
T
V
F
D
G
-
E
R
E
A
L
A
E
V
V
D
L
G
-
P
P
L
R
Y
R
V
L
-
E
E
R
-
R
--
P
-
E
R
---
E
V
G
V
E
-
V
V
L
Y
--
V
A
L
L
-
K
-
G
D
K
L
-
A
E
V
V
R
A
A
T
E
L
G
A
T
R
I
Q
P
L
V
T
R
H
S
V
P
K
E
M
G
---
E
G
K
L
R
R
L
R
A
V
A
L
E
A
A
K
Q
S
G
-
R
V
V
V
P
E
V
-----
L
P
P
I
P
L
K
A
V
P
Q
V
A
Q
--
G
---
L
V
A
H
V
G
A
T
-
A
-
R
V
R
E
V
-----
L
D
-
P
E
-
K
----------
P
L
A
L
A
V
G
P
E
G
G
----
F
A
E
E
E
V
A
L
L
E
A
R
G
F
T
P
V
S
L
G
R
R
I
L
R
A
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.13
33%
-74
- C5 -
2CX8
2
?
A:
[10-213]
----------------------------------------------------------------------------------------------------------------------
G
L
T
G
V
L
P
L
R
E
T
R
H
L
V
E
V
L
R
A
R
V
G
D
R
F
-
T
V
F
D
G
-
E
R
E
A
L
A
E
V
V
D
L
G
-
P
P
L
R
Y
R
V
L
-
E
E
R
-
R
--
P
-
E
R
---
E
V
G
V
E
-
V
V
L
Y
--
V
A
L
L
-
K
-
G
D
K
L
-
A
E
V
V
R
A
A
T
E
L
G
A
T
R
I
Q
P
L
V
T
R
H
S
V
P
K
E
M
G
---
E
G
K
L
R
R
L
R
A
V
A
L
E
A
A
K
Q
S
G
-
R
V
V
V
P
E
V
-----
L
P
P
I
P
L
K
A
V
P
Q
V
A
Q
--
G
---
L
V
A
H
V
G
A
T
-
A
-
R
V
R
E
V
-----
L
D
-
P
E
-
K
----------
P
L
A
L
A
V
G
P
E
G
G
----
F
A
E
E
E
V
A
L
L
E
A
R
G
F
T
P
V
S
L
G
R
R
I
L
R
A
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.83
24%
-93
- C5 -
2EGV
2
RSME_AQUAE
A:
[26-218]
--------------------------------------------------------------------------------------------------------------------------------------
V
R
R
I
E
K
D
E
E
F
G
V
I
H
E
G
--
K
I
Y
V
C
K
V
R
R
E
D
K
R
E
I
S
C
E
I
V
-
E
-
E
-
L
E
T
K
-
L
P
---
P
--
K
D
-
I
T
L
Y
--
Q
S
V
T
-
V
-
D
L
K
T
M
D
T
I
V
R
Q
A
T
E
L
G
V
L
T
F
V
P
I
I
S
E
R
S
F
Q
K
E
E
A
--
I
L
K
K
T
E
K
W
K
R
I
V
I
E
A
M
K
Q
S
R
-
R
----
P
I
P
M
E
I
K
K
P
V
R
L
S
D
L
I
P
E
S
E
E
--
N
I
I
L
D
N
F
Y
E
G
V
K
-
P
-
K
D
V
N
L
---------
E
-
A
---------
K
T
Y
S
V
V
V
G
P
E
G
G
----
F
S
K
R
E
S
Q
I
L
R
E
K
G
F
K
S
V
L
L
E
P
Y
T
L
R
T
E
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
61.37
18%
-110
- C5 -
2QMM
2
TRMY_ARCFU
A:
[3-197]
--------------------------------------------------------------------------------------------------------
A
V
R
G
F
L
I
V
G
N
K
A
F
T
Q
P
F
------------------
S
L
N
D
L
-
P
G
A
G
R
M
D
V
L
C
R
C
T
S
Q
A
L
---------------
F
--
I
-
S
H
---
G
I
R
R
D
-
V
E
V
Y
--
L
L
L
L
-
G
-
P
P
S
P
-
P
K
S
I
L
I
K
G
D
------------------
E
V
R
R
M
S
P
D
E
R
N
V
A
G
H
I
K
K
A
L
A
V
E
C
G
K
S
W
K
K
V
H
S
G
V
Y
V
S
R
K
G
L
E
E
L
I
E
E
L
S
E
--
K
Y
S
I
I
Y
L
K
E
D
G
------
V
D
I
-----
S
N
-
A
Q
L
P
---------
P
N
P
L
F
V
I
G
D
H
E
G
----
L
T
E
E
Q
E
K
V
V
E
R
Y
A
A
L
K
L
S
L
S
P
L
S
L
L
A
E
Q
C
V
V
I
A
H
-
H
H
L
D
R
L
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.86
24%
-89
- C5 -
2EGW
2
RSME_AQUAE
A:
[26-218]
--------------------------------------------------------------------------------------------------------------------------------------
V
R
R
I
E
K
D
E
E
F
G
V
I
H
E
G
--
K
I
Y
V
C
K
V
R
R
E
D
K
R
E
I
S
C
E
I
V
-
E
-
E
-
L
E
T
K
-
L
P
---
P
--
K
D
-
I
T
L
Y
--
Q
S
V
T
-
V
-
D
L
K
T
M
D
T
I
V
R
Q
A
T
E
L
G
V
L
T
F
V
P
I
I
S
E
R
S
F
Q
K
E
E
A
--
I
L
K
K
T
E
K
W
K
R
I
V
I
E
A
M
K
Q
S
R
-
R
----
P
I
P
M
E
I
K
K
P
V
R
L
S
D
L
I
P
E
S
E
E
--
N
I
I
L
D
N
F
Y
E
G
V
K
-
P
-
K
D
V
N
L
---------
E
-
A
---------
K
T
Y
S
V
V
V
G
P
E
G
G
----
F
S
K
R
E
S
Q
I
L
R
E
K
G
F
K
S
V
L
L
E
P
Y
T
L
R
T
E
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.73
25%
-91
- C5 -
1Z85
2
?
A:
[34-229]
----------------------------------------------------------------------------------------------------------------------------------
H
H
M
R
V
V
R
L
K
E
G
D
V
I
-
E
A
T
D
G
N
G
F
S
Y
T
C
I
L
K
S
L
K
K
K
T
A
A
A
K
I
V
-
K
-
V
-
E
--
E
-
K
E
---
K
E
P
T
E
K
L
S
V
V
--
V
P
I
G
-
R
-
W
E
R
T
-
R
F
L
I
E
K
C
V
E
L
G
V
D
E
I
F
F
H
K
F
E
R
-------
S
Q
H
E
I
S
L
D
K
A
K
I
V
V
R
E
A
A
K
Q
C
K
-
R
Y
L
F
P
K
V
S
F
L
-----------
E
K
L
E
F
--
S
G
N
V
I
T
L
D
L
----
Q
-
N
L
L
D
-------
A
-
N
L
-
E
---------
G
S
I
T
V
V
V
G
P
E
G
G
----
F
S
E
K
E
R
E
L
L
R
S
S
T
T
I
-
V
------
L
R
F
E
T
A
A
I
L
T
V
-
G
Y
I
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
59.30
33%
-59
- C5 -
1V6Z
-
?
A:
[11-227]
-----------------------------------------------------------------------------------------------------------------------
L
T
G
V
L
P
L
R
E
T
R
H
L
V
E
V
L
R
A
R
V
G
D
R
F
-
T
V
F
D
G
-
E
R
E
A
L
A
E
V
V
D
L
G
P
P
-
L
R
Y
R
V
L
-
E
E
R
-
R
--
P
-
E
R
---
E
V
G
V
E
-
V
V
L
Y
--
V
A
L
L
-
K
-
G
D
K
L
-
A
E
V
V
R
A
A
T
E
L
G
A
T
R
I
Q
P
L
V
T
R
H
S
V
P
K
E
M
---
G
E
G
K
L
R
R
L
R
A
V
A
L
E
A
A
K
Q
S
G
-
R
V
V
V
P
E
V
L
P
P
I
P
L
K
A
V
P
Q
V
A
----------
Q
G
L
V
A
H
V
G
A
T
-
A
-
R
V
R
E
V
------
L
-
D
P
-
E
---------
K
P
L
A
L
A
V
G
P
E
G
G
----
F
A
E
E
E
V
A
L
L
E
A
R
G
F
T
P
V
S
L
G
R
R
I
L
R
A
E
T
A
A
L
A
L
L
-
A
L
C
T
A
G
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.41
33%
-45
- C5 -
1V6Z
-
?
A:
[10-213]
----------------------------------------------------------------------------------------------------------------------
G
L
T
G
V
L
P
L
R
E
T
R
H
L
V
E
V
L
R
A
R
V
G
D
R
F
-
T
V
F
D
G
-
E
R
E
A
L
A
E
V
V
D
L
G
-
P
P
L
R
Y
R
V
L
-
E
E
R
-
R
--
P
-
E
R
---
E
V
G
V
E
-
V
V
L
Y
--
V
A
L
L
-
K
-
G
D
K
L
-
A
E
V
V
R
A
A
T
E
L
G
A
T
R
I
Q
P
L
V
T
R
H
S
V
P
K
E
M
G
---
E
G
K
L
R
R
L
R
A
V
A
L
E
A
A
K
Q
S
G
-
R
V
V
V
P
E
V
-----
L
P
P
I
P
L
K
A
V
P
Q
V
A
Q
--
G
---
L
V
A
H
V
G
A
T
-
A
-
R
V
R
E
V
-----
L
D
-
P
E
-
K
----------
P
L
A
L
A
V
G
P
E
G
G
----
F
A
E
E
E
V
A
L
L
E
A
R
G
F
T
P
V
S
L
G
R
R
I
L
R
A
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
53.35
24%
-22
- C5 -
1VHY
-
RSME_HAEIN
A:
[3-245]
----------------------------------------------------------------------------------------------------------
I
P
R
I
Y
H
P
I
S
L
E
N
Q
T
Q
C
Y
L
S
E
D
A
A
N
H
V
A
R
V
L
R
M
T
E
G
E
Q
L
-
E
L
F
D
G
S
N
H
I
Y
P
A
K
I
I
E
S
N
K
K
S
V
K
V
E
I
L
-
G
R
E
-
L
--
A
-
D
K
---
E
S
H
L
K
-
I
H
L
G
--
Q
V
I
------
R
M
-
E
F
T
I
Q
K
S
V
E
L
G
V
N
V
I
T
P
L
W
S
E
R
C
G
V
K
L
D
A
E
R
M
D
K
K
I
Q
Q
W
Q
K
I
A
I
A
A
C
E
Q
C
G
-
R
N
I
V
P
E
I
R
P
L
M
K
L
Q
D
W
C
A
E
N
D
-------
G
A
L
K
L
N
L
H
P
R
A
H
-
Y
-
S
I
K
T
L
-----
P
T
-
I
P
-
A
---------
G
G
V
R
L
L
I
G
S
E
G
G
----
L
S
A
Q
E
I
A
Q
T
E
Q
Q
G
F
T
E
I
L
L
G
K
R
V
L
R
T
E
T
A
S
L
A
A
I
-
S
A
L
Q
I
C
F
G
D
L
G
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.40
27%
-9
- C5 -
1NXZ
-
RSME_HAEIN
A:
[23-238]
------------------------------------------------------------------------------------------------------------------------------
D
A
A
N
H
V
A
R
V
L
R
M
T
E
G
E
Q
L
-
E
L
F
D
G
S
N
H
I
Y
P
A
K
I
I
E
S
N
K
K
S
V
K
V
E
I
L
G
R
-
E
-
L
--
A
-
D
K
---
E
S
H
L
K
-
I
H
L
G
--
Q
V
I
S
-
R
-
G
E
R
M
-
E
F
T
I
Q
K
S
V
E
L
G
V
N
V
I
T
P
L
W
S
E
R
C
G
V
K
L
D
A
E
R
M
D
K
K
I
Q
Q
W
Q
K
I
A
I
A
A
C
E
Q
C
G
-
R
N
I
V
P
E
I
-----
R
P
L
--
M
K
L
Q
D
W
C
A
E
ND
G
A
L
K
L
N
L
H
P
R
A
H
-
Y
-
S
I
K
T
L
-----
P
T
-
I
P
-
A
---------
G
G
V
R
L
L
I
G
S
E
G
G
----
L
S
A
Q
E
I
A
Q
T
E
Q
Q
G
F
T
E
I
L
L
G
K
R
V
L
R
T
E
T
A
S
L
A
A
I
-
S
A
L
Q
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
50.19
18%
-68
- C6 -
1PKL
1
KPYK_LEIME
A:
[2-499]
S
Q
L
A
H
N
L
T
LSIFDPVANYRA
A
R
I
I
C
T
I
G
PSTQS
V
E
A
L
K
G
L
I
Q
S
GMS
V
A
R
M
NFSHGS
H
E
Y
H
Q
T
T
I
N
N
V
R
Q
A
A
A
E
L
G
V
N
I
A
I
A
L
D
T
K
G
P
E
I
R
T
G
Q
F
VGG
D
A
V
M
E
R
G
A
T
C
Y
V
T
T
D
P
A
F
A
D
K
G
T
K
D
K
F
Y
I
D
---
Y
Q
N
L
S
K
V
V
R
P
G
N
Y
I
-
Y
I
D
D
G
--
I
L
I
L
Q
V
Q
S
H
E
D
E
Q
T
L
E
C
T
V
T
-
N
-
S
-
H
--
T
-
I
S
D
R
R
G
V
N
L
P
-
G
C
D
V
--
D
L
P
A
-
V
-
S
A
K
D
-
R
V
D
L
Q
F
G
V
E
Q
G
V
D
M
I
F
A
----------
S
F
I
R
S
A
E
Q
V
G
D
V
R
K
A
L
G
P
-------
K
G
R
D
I
M
I
I
C
K
I
E
N
H
Q
G
V
Q
N
I
D
S
I
I
E
E
--
S
D
G
I
M
V
A
R
G
D
L
G
-
V
-
E
I
P
A
E
-----
K
V
-
V
V
-
A
---------
Q
K
I
L
I
S
K
C
N
V
A
G
K
P
V
I
C
A
T
Q
M
L
E
S
M
T
Y
N
P
------
R
P
T
R
A
E
V
S
D
V
A
N
A
V
F
N
G
A
D
C
V
M
L
S
G
E
T
A
K
G
K
Y
P
N
E
V
V
Q
Y
M
A
R
I
C
L
E
A
Q
S
A
LN
E
Y
V
F
F
N
S
I
K
K
L
QHIPMS
A
D
E
A
V
C
S
S
A
V
N
S
V
Y
E
T
KAK
A
M
V
V
LSNTG
R
S
A
R
L
V
A
K
Y
RPN
C
P
I
V
C
V
T
TR
L
Q
T
C
R
Q
L
N
ITQG
V
E
S
V
F
F
DADKLGHDEGK
E
H
R
V
A
A
G
V
E
F
A
K
S
K
GYVQTG
D
Y
C
V
V
I
H
AA
N
Q
T
R
ILLVE
4
PsiBlast_PDB
49.61
27%
-8
- C5 -
1VHY
-
RSME_HAEIN
A:
[23-238]
------------------------------------------------------------------------------------------------------------------------------
D
A
A
N
H
V
A
R
V
L
R
M
T
E
G
E
Q
L
-
E
L
F
D
G
S
N
H
I
Y
P
A
K
I
I
E
S
N
K
K
S
V
K
V
E
I
L
G
R
-
E
-
L
--
A
-
D
K
---
E
S
H
L
K
-
I
H
L
G
--
Q
V
I
------
R
M
-
E
F
T
I
Q
K
S
V
E
L
G
V
N
V
I
T
P
L
W
S
E
R
C
G
V
K
L
D
A
E
R
M
D
K
K
I
Q
Q
W
Q
K
I
A
I
A
A
C
E
Q
C
G
-
R
N
I
V
P
E
I
-----
R
P
L
--
M
K
L
Q
D
W
C
A
E
ND
G
A
L
K
L
N
L
H
P
R
A
H
-
Y
-
S
I
K
T
L
-----
P
T
-
I
P
-
A
---------
G
G
V
R
L
L
I
G
S
E
G
G
----
L
S
A
Q
E
I
A
Q
T
E
Q
Q
G
F
T
E
I
L
L
G
K
R
V
L
R
T
E
T
A
S
L
A
A
I
-
S
A
L
Q
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------