@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2786c: (2016-05-13 )
MRRRLAIVQRWRGQDEIPTDWGRCVLTIGVFDGVHRGHAELIAHAVKAGRARGVPAVLMTFDPHPMEVVYPGSHPAQLTTLTRRAELVQDLGIEVFLVMPFTTDFMKLTPDRFIHELLVEHLHVVEVVVGENFTFGKKAAGNVDTLRRAGERFGFAVESMSLVSEHHSNETVTFSSTYIRSCVDAGDMVAAMEALGRPHRVEGVVVRGEGRGAELGFPTANVAPPMYSAIPADGVYAAWFTVLGHGPVTGTVVPGERYQAAVSVGTNPTFSGRTRTVEAFVLDTTADLYGQHVALDFVGRIRGQKKFESVRQLVAAMGADTERARDLLSTG
Atome Classification :
(31 SA)
.........10......--..20........30........40........50........60........70..--......80........90---........100.....---..110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-.-......220....-...230.---......240.-....-.-.250.......260.......270.-......280..-.....290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
R
R
L
A
I
V
Q
R
WRGQDEI--PTDWG
R
C
V
L
T
I
GVFD
G
V
HR
G
H
A
E
L
I
A
H
A
V
K
AGRARGV
P
A
V
L
M
TFDPHP
M
E
V
VYPGS--H
P
A
Q
L
T
T
L
T
R
R
A
E
L
V
Q
DL---G
I
E
V
F
L
V
MPFT
T
D
F
M
K---L
T
P
D
R
F
I
H
E
L
L
V
E
H
L
H
V
V
E
V
V
VGENFTFGKKAAG
N
V
D
T
L
R
R
A
G
E
R
FG
F
A
V
E
S
M
S
L
V
S
E
HHSN
E
T
V
T
F
S
S
T
Y
I
R
S
C
VDA
G
D
M
V
A
A
M
E
A
LGRPHR
V
E
G
V
V
V
RGEGRG-A-ELGFPTANVAP
P
M
-
Y
SAIPAD---
G
V
Y
A
A
W
F
T
V
L-GHGP-V-
T
G
T
VVPGE
R
Y
Q
A
A
V
SVGTNPTFSGR-
T
R
T
V
E
A
F
V
LDT-
T
A
D
L
Y
G
Q
H
V
A
L
D
F
V
G
R
IRG
Q
K
K
F
E
S
V
R
Q
L
V
A
AMGA
D
T
E
R
A
R
D
L
LSTG
4
PsiBlast_PDB
97.46
45%
-126
- C5 -
3ZUG
3
RIBF_CORAM
A:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
---
D
E
-
Q
R
S
V
D
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
23
PsiBlast_CBE
97.19
45%
-124
- C5 -
2X0K
3
RIBF_CORAM
B:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
35
HHSearch
97.13
45%
-123
- C5 -
2X0K
3
RIBF_CORAM
A:
[1-320]
-------
M
D
I
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
D
D
E
----
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
-
P
T
E
A
-
P
V
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
-
2
PsiBlast_PDB
96.92
45%
-124
- C5 -
4UZF
3
RIBF_CORAM
A:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
----
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
1
PsiBlast_PDB
96.66
45%
-123
* C5 *
4UZE
3
RIBF_CORAM
A:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
3
PsiBlast_PDB
96.56
45%
-125
- C5 -
2X0K
3
RIBF_CORAM
A:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
22
PsiBlast_CBE
96.37
45%
-128
- C5 -
4UZF
3
RIBF_CORAM
B:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
E
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
24
PsiBlast_CBE
96.02
45%
-125
- C5 -
3ZUG
3
RIBF_CORAM
B:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
R
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
----
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
---
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
-
Q
R
S
V
D
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
21
PsiBlast_CBE
95.37
45%
-123
- C5 -
4UZE
3
RIBF_CORAM
B:
[4-319]
----------
W
Y
G
T
A
A
V
--
P
K
D
L
D
N
S
A
V
T
I
G
V
F
D
G
V
H
R
G
H
Q
K
L
I
N
A
T
V
E
K
A
R
E
V
G
A
K
A
I
M
V
T
F
D
P
H
P
V
S
V
F
L
P
R
A
--
A
P
L
G
I
T
T
L
A
E
R
F
A
L
A
E
S
F
---
G
I
D
G
V
L
V
I
D
F
T
R
E
L
S
G
---
T
S
P
E
K
Y
V
E
F
L
L
E
D
T
L
H
A
S
H
V
V
V
G
A
N
F
T
F
G
E
N
A
A
G
T
A
D
S
L
R
Q
I
C
Q
S
-
R
L
T
V
D
V
I
D
L
L
----
D
D
E
G
V
R
I
S
S
T
T
V
R
E
F
L
S
E
G
D
V
A
R
A
N
W
A
L
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
---
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
36
HHSearch
82.27
33%
-118
- C5 -
3OP1
10
?
A:
[17-307]
--------------------
G
T
P
S
D
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
E
P
Y
H
PD
L
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
---
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
---
L
T
A
Q
E
F
F
A
T
Y
I
-
K
A
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
K
K
-
T
A
E
D
L
K
N
Y
---
F
D
G
E
V
I
I
V
P
P
V
E
D
E
----
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
L
L
D
-
R
T
Y
M
P
A
D
---
G
V
Y
V
V
D
V
E
I
Q
--
R
------------
Q
K
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
---
E
A
R
F
E
V
N
I
F
D
F
-
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
W
----
5
PsiBlast_PDB
77.08
31%
-111
- C5 -
3OP1
10
?
A:
[11-306]
-----------
K
N
Q
K
D
I
GT
P
S
D
---
S
V
V
V
L
G
Y
F
D
G
I
H
K
G
H
Q
E
L
F
R
V
A
N
K
A
A
R
K
D
L
L
P
I
V
V
M
T
F
N
E
S
P
K
I
A
L
E
P
-
Y
--
H
P
D
L
F
L
H
I
L
N
P
A
E
R
E
R
K
L
K
R
E
G
V
E
E
L
Y
L
L
D
F
S
S
Q
F
A
S
---
L
T
A
Q
E
F
F
-
A
T
Y
I
K
A
M
N
A
K
I
I
V
A
G
F
D
Y
T
F
G
S
D
--------
K
K
T
A
E
D
L
K
N
Y
F
D
G
E
V
I
I
V
P
P
V
E
D
E
K
G
K
I
S
S
T
R
I
R
Q
A
I
L
D
G
N
V
K
E
A
G
K
L
L
G
A
P
L
P
S
R
G
M
V
V
H
G
N
--------
G
Y
P
T
A
N
L
V
L
L
D
-
R
T
Y
M
P
A
D
---
G
V
Y
-------------
V
-
V
D
V
E
I
Q
R
Q
K
Y
R
A
M
A
S
V
G
K
N
V
T
F
D
---
E
A
R
F
E
V
N
I
F
D
F
-
N
Q
D
I
Y
G
E
T
V
M
V
Y
W
L
D
R
I
R
D
M
T
K
F
D
S
V
D
Q
L
V
D
Q
L
K
A
D
E
E
V
T
R
N
-----
33
PsiBlast_CBE
72.44
31%
-123
- C5 -
1S4M
1
?
B:
[1-282]
-------------------------
M
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
30
PsiBlast_CBE
72.02
31%
-117
- C5 -
1T6Z
1
?
B:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
34
PsiBlast_CBE
71.49
31%
-121
- C5 -
1MRZ
2
?
B:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
I
K
D
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
37
HHSearch
71.12
32%
-119
- C5 -
1MRZ
1
?
A:
[2-283]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
S
Y
P
P
E
Y
F
L
P
D
----
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
--
R
T
V
V
L
D
F
F
-
R
I
K
D
---
L
T
P
E
G
F
V
E
R
Y
L
---
S
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
----
G
V
E
V
Y
E
I
E
D
V
V
V
Q
----
G
K
R
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
E
K
L
V
D
L
K
R
---
G
V
Y
L
V
R
V
H
L
P
-
D
G
------------
K
K
K
F
G
V
M
N
V
G
F
R
------R
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
D
-
13
PsiBlast_PDB
70.75
31%
-119
- C5 -
1S4M
2
?
A:
[1-282]
-------------------------
M
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
R
P
T
-
D
A
R
-
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
32
PsiBlast_CBE
69.66
31%
-119
- C5 -
1T6X
1
?
B:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
9
PsiBlast_PDB
69.48
31%
-116
- C5 -
1MRZ
1
?
A:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
R
-----
R
-
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
31
PsiBlast_CBE
69.46
31%
-115
- C5 -
1T6Y
3
?
B:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
--------
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
F
D
S
I
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
11
PsiBlast_PDB
69.08
31%
-111
- C5 -
1T6Y
3
?
A:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
H
K
-----------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R
--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
R
-----
R
-
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
10
PsiBlast_PDB
68.00
31%
-115
- C5 -
1T6X
1
?
A:
[2-282]
--------------------------
V
V
S
I
G
V
F
D
G
V
H
I
G
H
Q
K
V
L
R
T
M
K
E
I
A
F
F
R
K
D
D
S
L
I
Y
T
I
-
S
Y
P
P
E
Y
F
L
P
-
D
--
F
P
G
L
L
M
T
V
E
S
R
V
E
M
L
S
R
Y
---
A
R
T
V
V
L
------
D
F
F
R
IKD
L
T
P
E
G
F
V
E
R
Y
L
S
---
G
V
S
A
V
V
V
G
R
D
F
R
F
G
K
N
A
S
G
N
A
S
F
L
R
K
K
G
V
E
V
-
Y
E
I
E
D
V
V
V
Q
G
K
R
-------
V
S
S
S
L
I
R
N
L
V
Q
E
G
R
V
E
E
I
P
A
Y
L
G
R
Y
F
E
I
E
G
I
V
-------------
F
P
T
A
N
I
D
R
G
N
-
E
K
L
V
D
L
K
R--
G
V
Y
----
L
V
R
-
V
H
L
P
--------
D
G
K
K
K
F
G
V
M
N
V
G
F
R
-----
R
-
N
V
K
Y
E
V
Y
I
L
D
F
-
E
G
D
L
Y
G
Q
R
L
K
L
E
V
L
K
F
M
R
D
E
K
K
----
E
E
L
K
A
A
I
D
Q
D
V
K
S
A
R
N
M
I
D
--
6
PsiBlast_PDB
57.86
53%
-108
- C5 -
5A88
4
RIBF_CORAM
A:
[3-137]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
-------
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
8
PsiBlast_PDB
56.41
53%
-98
- C5 -
5A8A
6
RIBF_CORAM
A:
[2-137]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
26
PsiBlast_CBE
56.38
53%
-99
- C5 -
5A89
6
B:
[4-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
29
PsiBlast_CBE
55.79
53%
-122
- C5 -
5A88
3
RIBF_CORAM
B:
[4-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
------
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
--------
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
-
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
27
PsiBlast_CBE
55.48
53%
-112
- C5 -
5A88
3
D:
[4-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
---------
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
-------
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
28
PsiBlast_CBE
55.41
53%
-111
- C5 -
5A88
5
RIBF_CORAM
C:
[4-145]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
-------
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
7
PsiBlast_PDB
54.93
53%
-95
- C5 -
5A89
5
RIBF_CORAM
A:
[4-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
38
HHSearch
54.85
53%
-94
- C5 -
5A89
5
RIBF_CORAM
A:
[4-138]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
G
K
-
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
-
P
T
E
A
P
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
Q
-
25
PsiBlast_CBE
54.47
53%
-99
- C5 -
5A8A
5
B:
[4-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
Y
V
T
G
P
V
V
R
G
A
G
R
G
-
G
K
E
L
G
F
P
T
A
N
Q
Y
F
H
D
-
T
V
A
L
P
A
D
---
G
V
Y
A
G
W
L
T
I
L
P
T
E
A
P
-
V
-
S
G
N
M
E
P
E
V
A
Y
A
A
A
I
S
V
G
T
N
P
T
F
G
D
E
-
Q
R
S
V
E
S
F
V
L
D
R
-
D
A
D
L
Y
G
H
D
V
K
V
E
F
V
D
H
V
R
A
M
E
K
F
D
S
V
E
Q
L
L
E
V
M
A
K
D
V
Q
K
T
R
T
L
L
A
--
18
PsiBlast_PDB
45.80
33%
-93
- C5 -
1P4M
3
RIFK_HUMAN
A:
[4-129]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
F
C
R
G
Q
V
V
R
G
F
G
R
G
-
S
K
Q
L
G
I
P
T
A
N
F
P
E
Q
V
-
V
D
N
L
P
A
D
I
S
T
G
I
Y
Y
G
W
-------------
A
S
V
G
S
G
D
V
H
K
M
V
V
S
I
G
W
N
P
Y
Y
K
N
T
-
K
K
S
M
E
T
H
I
M
H
T
F
K
E
D
F
Y
G
E
I
L
N
V
A
I
V
G
Y
L
R
P
E
K
N
F
D
S
L
E
S
L
I
S
A
I
Q
G
D
I
E
E
A
K
K
R
L
---