@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0134: (2015-12-23 )
MNDAVPAGNFVPPLILHSDHGGSAMSSSAHRGRILHFLGDPAKLGDKAWEYFEDGLLWIEHGHVRALDHATYLLPQLPADLPLEEHPQRLLLPGFVDCHVHYPQLGVIASYGTQLLDWLETHTFPAEQRFADAGYAAAQAELFLDELLRHGTTTALVFGTVHAVSAEAFFQAAQKRRLRMIAGKVLMDRNAPPALCDTAASGYAESRALIERWHGNGRLQYAVTPRFAPTSSPEQLAAAARLLDEYPGVYLHTHLSENLKEVAWVGELFPQAQDYLDVYHRAGLVGERSVFAHGIHLSERECRCLAHKNAALAHCPSSNLFIGSGLFDLGRAQQYGIRVGIGSDVGGGTSLSLLANLADAYKIQQLRGTSLDPFQALYLATLGGARALDLDGLVGNFLPGREADFVALDLAATPMIAQRMEHARGLADTLFVLNTLGDDRAVAETWVMGERRHVKG
Atome Classification :
(20 SA)
.........10........20........30..-.-....-.40........50........-60........70........80.....---...90........100--..-.---.---...-.110--.------.......120-----.......----.130--.......140.......150....--..-----.160-----------.-----.--.....170-.......--..180.....-..190-----..------.----.-----..-----...200....-...210..-----.-----.---..---.-220......-.230..-.....240.......250.........260.......270-........280.....-.-.290.......300.......310.......320.......330.......340..-....-.-350..------.....360--.....---.----------.---.-------370.-----.----.....380.......390.......400.......410--.......420.......430........440.......450....---------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNDAVPAGNFVP
P
L
I
L
HSDHGGSAMSSSAHR
G
R
-
I
-
L
H
FL-G
D
P
A
K
L
G
D
K
A
W
E
Y
F
ED
G
L
L
W
I
-EHGH
V
R
A
L
D
H
A
T
Y
L
L
PQLPADLP
L
E
EH---PQRLLLPG
F
V
D
C
H
VH---YP-Q---L---
G
V
I
-
A
S
Y
---
G
------
T
Q
L
L
D
W
L
E
T------HTF
P
A
E
Q
----
R
FAD--AGY
A
A
A
Q
A
E
L
F
L
D
E
L
L
RHGT
T
T
A
L
--
V
F
-----GT
V
H
-----------
A
-----
V
--
S
A
E
A
F
F
---
Q
A
A
Q
K
R
R
--
L
R
M
I
A
G
K
V
LM-DRN-------A
P
------
P
----
A
-----
L
C
-----
D
T
A
ASG
Y
A
E
S
-
R
A
L
I
E
RWH-----G-----N---
G
R
---
L
-
Q
Y
A
VTPRFA-PTS
S
P
E
-
Q
L
A
A
A
A
R
L
L
D
EYP
G
V
Y
--
L
H
T
H
L
S
E
N
L
K
E
V
A
W
V
G
E
L
F
P
Q
--
A
Q
D
Y
L
D
V
Y
H
RAGLVGE-R-S
V
F
AHGIHLS
E
R
E
C
R
C
L
AHKNA
A
L
AHCPSS
N
L
F
I
GSG
L
F
DLGRAQQ
Y
G
I
R
V
GIGSD-VGGG-
T
-
S
L
S
L
L
------
A
N
L
A
D
A
Y
---
K
I
Q
Q
L---R----------G---T-------SL
D
P
-----
F
----
Q
A
L
Y
L
A
TLGG
A
R
A
LDLD
G
L
VGNFLPGREA
D
F
V
A
L
DLAA--
T
P
M
I
A
Q
R
M
E
H
ARG
L
A
D
T
L
F
-
V
L
NTLGD
D
R
A
V
A
E
T
WVMGERRHVKG---------------------------
111
Fugue
94.88
27%
-98
- C1 -
2I9U
3
?
A:
[9-427]
-----------
N
L
K
I
F
K
--------------
G
N
-
L
-
I
F
T
K
-
T
S
D
------
K
F
T
I
M
K
D
S
Y
I
V
V
-
I
D
G
K
I
A
S
V
S
S
N
L
---
P
D
K
Y
K
G
N
P
I
I
D
F
---
R
N
N
I
I
I
P
G
M
N
D
L
H
A
H
---
A
S
-
Q
---
Y
---
K
N
L
G
I
G
M
---
D
------
K
E
L
L
P
W
L
N
N
------
Y
T
F
P
E
E
A
----
K
F
L
N
--
V
D
Y
A
K
K
T
Y
G
R
L
I
K
D
L
I
K
N
G
T
T
R
V
A
--
L
F
-----
A
T
L
H
-----------
K
-----
D
--
S
T
I
E
L
F
---
N
M
L
I
K
S
G
--
I
G
A
Y
V
G
K
V
N
M
-
D
Y
N
-------
C
P
------
D
----
Y
-----
L
T
-----
E
N
Y
I
T
S
L
N
D
T
-
E
E
I
I
L
K
Y
K
-----
D
K----
S
---
N
I
---
V
-
K
P
I
I
T
P
R
F
V
-
P
S
C
S
N
E
-
L
M
D
G
L
G
K
L
S
Y
K
Y
-
R
L
P
--
V
Q
S
H
L
S
E
N
L
D
E
I
A
V
V
K
S
L
H
K
K
--
S
N
F
Y
G
E
V
Y
D
K
F
G
L
F
G
N
T
P
-
T
L
M
A
H
C
I
H
S
S
K
E
E
I
N
L
I
K
R
N
N
V
T
I
V
H
C
P
T
S
N
F
N
L
G
S
G
M
M
P
V
R
K
Y
L
N
L
G
I
N
V
V
L
G
S
D
-
I
S
A
G
-
H
-
T
C
S
L
F
------
K
V
I
A
Y
A
I
---
Q
N
S
K
I
---
K
----------
W
---
Q
E
S
G
KKDM
F
L
S
T
-----
S
----
E
A
F
Y
M
A
T
K
K
G
G
S
F
F
---
G
K
V
G
S
F
E
E
G
Y
D
F
D
A
L
V
I
N
D
S
N
--
L
Y
------
P
E
D
Y
D
L
T
E
R
L
E
-
R
F
I
Y
L
G
D
D
R
N
I
M
K
R
Y
V
C
G
N
E
I
F
------------------------------
4
PsiBlast_PDB
94.87
29%
-99
- C1 -
2I9U
3
?
A:
[20-425]
--------------------------------------------
T
K
T
S
D
K
-
F
T
I
M
K
D
S
Y
I
V
V
-
I
D
G
K
I
A
S
V
S
S
N
---
L
P
D
K
Y
K
G
N
P
I
I
D
F
---
R
N
N
I
I
I
P
G
M
N
D
L
H
A
H
ASQ
Y
K
-
N
---
L
---
G
I
---
G
M
---
D
------
K
E
L
L
P
W
L
N
N
------
Y
T
F
P
E
E
A
----
K
F
L
N
--
V
D
Y
A
K
K
T
Y
G
R
L
I
K
D
L
I
K
N
G
T
T
R
V
A
--
L
F
-----
A
T
L
H
-----------
K
-----
D
--
S
T
I
E
L
F
---
N
M
L
I
K
S
G
--
I
G
A
Y
V
G
K
V
N
M
-
D
Y
N
-------
C
P
------
D
----
Y
-----
L
T
-----
E
N
Y
I
T
S
L
N
D
T
-
E
E
I
I
L
K
Y
K
-----
D
-----
K
---
S
N
---
I
V
K
P
I
I
T
P
R
F
V
-
P
S
C
S
N
E
-
L
M
D
G
L
G
K
L
S
Y
K
Y
R
-
L
P
--
V
Q
S
H
L
S
E
N
L
D
E
I
A
V
V
K
S
L
H
K
K
--
S
N
F
Y
G
E
V
Y
D
K
F
G
L
F
G
N
-
T
P
T
L
M
A
H
C
I
H
S
S
K
E
E
I
N
L
I
K
R
N
N
V
T
I
V
H
C
P
T
S
N
F
N
L
G
S
G
M
M
P
V
R
K
Y
L
N
L
G
I
N
V
V
L
G
S
D
-
I
S
A
G
-
H
-
T
C
S
L
F
------
K
V
I
A
Y
A
I
Q
N
S
K
I
K
W
Q
---
E
----------
S
---
G
-------
K
K
D
M
-----
F
LS
T
S
E
A
F
Y
M
A
T
K
K
G
G
S
F
F
---
G
K
V
G
S
F
E
E
G
--
Y
D
F
D
A
L
V
I
N
D
--
S
N
L
Y
P
E
D
Y
D
L
T
E
R
L
E
R
F
I
Y
-----
L
G
D
D
R
N
I
M
K
R
Y
V
C
G
N
E
I
F
------------------------------
84
HHSearch
93.59
27%
-92
- C1 -
2I9U
3
?
A:
[9-427]
------------------------
N
L
K
I
F
K
G
N
L
-
I
-
F
T
K
T
-
S
-------
D
K
F
T
I
M
K
D
S
Y
I
V
V
-
I
D
G
K
I
A
S
V
S
S
N
L
P
D
K
---
Y
K
G
N
P
I
I
D
F
---
R
N
N
I
I
I
P
G
M
N
D
L
H
A
H
---
A
S
-
Q
---
Y
---
K
N
L
-
G
I
G
M--
D
------
K
E
L
L
P
W
L
N
N
------
Y
T
F
P
E
E
A
----
K
F
L
N
--
V
D
Y
A
K
K
T
Y
G
R
L
I
K
D
L
I
K
N
G
T
T
R
V
A
--
L
F
-----
A
T
L
H
-----------
K
-----
D
--
S
T
I
E
L
F
---
N
M
L
I
K
S
G
--
I
G
A
Y
V
G
K
V
N
M
-
D
Y
N
-------
C
P
------
D
----
Y
-----
L
T
-----
E
N
Y
I
T
S
L
N
D
T
-
E
E
I
I
L
K
Y
K
D----
K
-----
S
---
N
I
---
V
-
K
P
I
I
T
P
R
F
V
-
P
S
C
S
N
E
-
L
M
D
G
L
G
K
L
S
Y
K
Y
-
R
L
P
--
V
Q
S
H
L
S
E
N
L
D
E
I
A
V
V
K
S
L
H
K
K
--
S
N
F
Y
G
E
V
Y
D
K
F
G
L
F
G
N
T
P
-
T
L
M
A
H
C
I
H
S
S
K
E
E
I
N
L
I
K
R
N
N
V
T
I
V
H
C
P
T
S
N
F
N
L
G
S
G
M
M
P
V
R
K
Y
L
N
L
G
I
N
V
V
L
G
S
D
-
I
S
A
G
-
H
-
T
C
S
L
F
------
K
V
I
A
Y
A
I
---
Q
N
S
K
I
---
K
W
Q
E
S
G
KK---
D
---
M
-------
F
L
S
T
-----
S
----
E
A
F
Y
M
A
T
K
K
G
G
S
F
F
G
---
K
V
G
S
F
E
E
G
Y
D
F
D
A
L
V
I
N
D
S
N
--
L
Y
P
E
D
------
Y
D
L
T
E
R
L
E
-
R
F
I
Y
L
G
D
D
R
N
I
M
K
R
Y
V
C
G
N
E
I
F
------------------------------
89
HHSearch
89.26
25%
-93
- C1 -
3HPA
1
?
A:
[29-453]
------------------------
K
T
L
L
V
K
H
A
D
-
V
L
V
T
M
D
---------
D
T
R
R
E
L
R
D
A
G
L
Y
I
-
E
D
N
R
I
V
A
V
G
P
S
A
E
L
P
---
E
T
A
D
E
V
L
D
L
---
R
G
H
L
V
I
P
G
L
V
N
T
H
H
H
---
M
Y
-
Q
---
S
---
L
T
R
-
A
V
P
AAQ
N
------
A
E
L
F
G
W
L
T
N
------
L
Y
K
I
W
-
A
----
H
-
L
T
--
P
E
M
I
E
V
S
T
L
T
A
M
A
E
L
L
Q
S
G
C
T
T
S
S
--
D
H
-----
L
Y
I
Y
-----------
P
-----
N
GS
R
L
D
D
S
I
---
G
A
A
Q
R
I
G
--
M
R
F
H
A
S
R
G
A
M
-
S
-------------------------------------
E
P
D
I
L
R
D
T
-
Q
R
L
I
E
T
Y
H
-----
D
EGR--
Y
---
A
M
---
L
-
R
V
V
V
A
P
C
S
P
-
F
S
V
S
R
D
-
L
M
R
D
A
A
V
L
A
R
E
Y
-
G
V
S
--
L
H
T
H
L
A
E
N
V
N
D
I
A
Y
-----------
T
P
A
E
Y
A
E
D
L
G
W
V
G
H
-
D
-
V
W
H
A
H
C
V
Q
L
D
D
A
G
I
G
L
F
A
R
T
G
T
G
V
A
H
C
P
C
S
N
M
R
L
A
S
G
I
A
P
V
K
K
M
R
L
A
G
V
P
V
G
L
G
V
D
-
G
S
A
S
N
D
-
G
A
Q
M
V
------
A
E
V
R
Q
A
L
---
L
L
Q
R
V
---
G
FG--------
P
---
D
-------
A
M
T
A
-----
R
----
E
A
L
E
I
A
T
L
G
G
A
K
V
L
N
R
D
-
D
I
G
A
L
K
P
G
M
A
A
D
F
A
A
F
D
L
R
Q
--
P
L
F
A
G
-------
A
L
H
D
P
V
A
-
A
L
V
F
C
A
-
P
S
Q
T
A
Y
T
V
V
N
G
K
V
V
V
R
E
G
---------------------------
1
PsiBlast_PDB
89.22
32%
-88
- C1 -
2UZ9
2
GUAD_HUMAN
A:
[94-468]
-----------------------------------------------------------------------------------------------
E
F
F
M
P
G
L
V
D
T
H
I
H
---
A
S
-
Q
---
Y
---
S
F
A
G
S
S
I
---
D
------
L
P
L
L
E
W
L
T
K
------
Y
T
F
P
A
E
H
----
R
F
Q
N
--
I
D
F
A
E
E
V
Y
T
R
V
V
R
R
T
L
K
N
G
T
T
T
A
C
--
Y
F
-----
A
T
I
H
-----------
T
-----
D
--
S
S
L
L
L
A
---
D
I
T
D
K
F
G
--
Q
R
A
F
V
G
K
V
C
M
-
D
L
N
-------
D
T
F-----
P
----
E
-----
Y
K
-----
E
T
T
E
E
S
I
K
E
T
E
R
F
V
S
E
M
L
Q
-----
K
-----
N
Y--
S
R
---
V
-
K
P
I
V
T
P
R
F
S
-
L
S
C
S
-
E
-
T
L
M
G
E
L
G
N
I
A
K
T
R
D
L
H
--
I
Q
S
H
I
S
E
N
R
D
E
V
E
A
V
K
N
L
Y
P
S
--
Y
K
N
Y
T
S
V
Y
D
K
N
N
L
L
T
N
-
K
-
T
V
M
A
H
G
C
Y
L
S
A
E
E
L
N
V
F
H
E
R
G
A
S
I
A
H
C
P
N
S
N
L
S
L
S
S
G
F
L
N
V
L
E
V
L
K
H
E
V
K
I
G
L
G
T
D
-
V
A
G
G
-
Y
-
S
Y
S
M
L
D
A
I
R
R
A
V
M
V
S
N
I
L
---
L
I
N
K
V
---
N
----------
E
---
K
-------
S
L
T
L
-----
K
----
E
V
F
R
L
A
T
L
G
G
S
Q
A
L
G
L
D
G
E
I
G
N
F
E
V
G
K
E
F
D
A
I
L
I
N
P
K
A
SD
S
P
I
D
L
F
Y
G
D
F
F
G
D
I
S
E
A
V
I
Q
K
F
L
Y
L
G
D
D
R
N
I
E
E
V
Y
V
G
G
K
Q
V
V
P
F
S
---------------------------
2
PsiBlast_PDB
88.34
32%
-87
- C1 -
4AQL
2
GUAD_HUMAN
A:
[94-468]
-----------------------------------------------------------------------------------------------
E
F
F
M
P
G
L
V
D
T
H
I
H
---
A
S
-
Q
---
Y
---
S
F
A
G
S
S
I
---
D
------
L
P
L
L
E
W
L
T
K
------
Y
T
F
P
A
E
H
----
R
F
Q
N
--
I
D
F
A
E
E
V
Y
T
R
V
V
R
R
T
L
K
N
G
T
T
T
A
C
--
Y
F
-----
A
T
I
H
-----------
T
-----
D
--
S
S
L
L
L
A
---
D
I
T
D
K
F
G
--
Q
R
A
F
V
G
K
V
C
M
-
D
L
N
-------
D
T
F-----
P
----
E
-----
Y
K
-----
E
T
T
E
E
S
I
K
E
T
E
R
F
V
S
E
M
L
Q
-----
K
-----
N
Y--
S
R
---
V
-
K
P
I
V
T
P
R
F
S
-
L
S
C
S
-
E
-
T
L
M
G
E
L
G
N
I
A
K
T
R
D
L
H
--
I
Q
S
H
I
S
E
N
R
D
E
V
E
A
V
K
N
L
Y
P
S
--
Y
K
N
Y
T
S
V
Y
D
K
N
N
L
L
T
N
-
K
-
T
V
M
A
H
G
C
Y
L
S
A
E
E
L
N
V
F
H
E
R
G
A
S
I
A
H
C
P
N
S
N
L
S
L
S
S
G
F
L
N
V
L
E
V
L
K
H
E
V
K
I
G
L
G
T
D
-
V
A
G
G
-
Y
-
S
Y
S
M
L
D
A
I
R
R
A
V
M
V
S
N
I
L
---
L
I
N
K
V
---
N
----------
E
---
K
-------
S
L
T
L
-----
K
----
E
V
F
R
L
A
T
L
G
G
S
Q
A
L
G
L
D
G
E
I
G
N
F
E
V
G
K
E
F
D
A
I
L
I
N
P
K
A
SD
S
P
I
D
L
F
Y
G
D
F
F
G
D
I
S
E
A
V
I
Q
K
F
L
Y
L
G
D
D
R
N
I
E
E
V
Y
V
G
G
K
Q
V
V
P
F
----------------------------
21
PsiBlast_CBE
87.13
31%
-92
- C1 -
3E0L
1
GUAD_HUMAN
B:
[75-447]
-----------------------------------------------------------------------------------------------
E
F
F
M
P
G
L
V
D
T
H
I
H
---
A
S
-
Q
---
Y
---
S
F
A
G
S
S
I
---
D
------
L
P
L
L
E
W
L
T
K
------
Y
T
F
P
A
E
H
----
R
F
Q
N
--
I
D
F
A
E
E
V
Y
T
R
V
V
R
R
T
L
K
N
G
T
T
T
A
C
--
Y
F
-----
A
T
I
H
-----------
T
-----
D
--
S
S
L
L
L
A
---
D
I
T
D
K
F
G
--
Q
R
A
F
V
G
K
V
C
M
-
D
L
N
-------
D
T
F-----
P
----
E
-----
Y
K
-----
E
T
T
E
E
S
I
K
E
T
E
R
F
V
S
E
M
L
Q
-----
K
-----
N
Y--
S
R
---
V
-
K
P
I
V
T
P
G
N
G
-
V
S
E
T
L
M
G
E
L
G
N
I
A
K
T
R
D
----
L
H
--
I
Q
S
H
I
S
E
N
R
D
E
V
E
A
V
K
N
L
Y
P
S
--
Y
K
N
Y
T
S
V
Y
D
K
N
N
L
L
T
N
-
K
-
T
V
M
A
H
G
C
Y
L
S
A
E
E
L
N
V
F
H
E
R
G
A
S
I
A
H
C
P
N
S
N
L
S
L
S
S
G
F
L
N
V
L
E
V
L
K
H
E
V
K
I
G
L
G
T
D
-
V
A
G
G
-
Y
-
S
Y
S
M
L
DAIRRA
V
M
V
S
N
I
L
---
L
I
N
K
V
---
N
----------
E
---
K
-------
S
L
T
L
-----
K
----
E
V
F
R
L
A
T
L
G
G
S
Q
A
L
G
L
D
G
E
I
G
N
F
E
V
G
K
E
F
D
A
I
L
I
N
P
K
A
SD
S
P
I
D
L
F
Y
G
D
F
F
G
D
I
S
E
A
V
I
Q
K
F
L
Y
L
G
D
D
R
N
I
E
E
V
Y
V
G
G
K
Q
V
V
P
F
S
---------------------------
3
PsiBlast_PDB
86.27
31%
-92
- C1 -
3E0L
1
GUAD_HUMAN
A:
[75-447]
-----------------------------------------------------------------------------------------------
E
F
F
M
P
G
L
V
D
T
H
I
H
---
A
S
-
Q
---
Y
---
S
F
A
G
S
S
I
---
D
------
L
P
L
L
E
W
L
T
K
------
Y
T
F
P
A
E
H
----
R
F
Q
N
--
I
D
F
A
E
E
V
Y
T
R
V
V
R
R
T
L
K
N
G
T
T
T
A
C
--
Y
F
-----
A
T
I
H
-----------
T
-----
D
--
S
S
L
L
L
A
---
D
I
T
D
K
F
G
--
Q
R
A
F
V
G
K
V
C
M
-
D
L
N
-------
D
T
F-----
P
----
E
-----
Y
K
-----
E
T
T
E
E
S
I
K
E
T
E
R
F
V
S
E
M
L
Q
-----
K
-----
N
Y--
S
R
---
V
-
K
P
I
V
T
P
G
N
G
-
V
S
E
T
L
M
G
E
L
G
N
I
A
K
T
R
D
----
L
H
--
I
Q
S
H
I
S
E
N
R
D
E
V
E
A
V
K
N
L
Y
P
S
--
Y
K
N
Y
T
S
V
Y
D
K
N
N
L
L
T
N
-
K
-
T
V
M
A
H
G
C
Y
L
S
A
E
E
L
N
V
F
H
E
R
G
A
S
I
A
H
C
P
N
S
N
L
S
L
S
S
G
F
L
N
V
L
E
V
L
K
H
E
V
K
I
G
L
G
T
D
-
V
A
G
G
-
Y
-
S
Y
S
M
L
D
A
I
R
R
A
V
M
V
S
N
I
L
---
L
I
N
K
V
---
N
----------
E
---
K
-------
S
L
T
L
-----
K
----
E
V
F
R
L
A
T
L
G
G
S
Q
A
L
G
L
D
G
E
I
G
N
F
E
V
G
K
E
F
D
A
I
L
I
N
P
K
A
SD
S
P
I
D
L
F
Y
G
D
F
F
G
D
I
S
E
A
V
I
Q
K
F
L
Y
L
G
D
D
R
N
I
E
E
V
Y
V
G
G
K
Q
V
V
P
F
S
---------------------------
86
HHSearch
85.49
23%
-86
* C1 *
3LNP
5
?
A:
[21-442]
----------------------
A
H
A
D
L
R
I
N
S
H
W
-
I
-
I
P
I
E
-
N
T
-------
V
S
N
I
L
I
D
H
C
L
L
I
-
K
D
G
I
I
L
A
I
E
P
Q
S
S
C
Q
---
I
P
A
T
E
T
L
D
L
---
G
Q
Q
V
L
M
P
G
W
V
N
A
H
G
H
---
A
A
-
M
---
S
---
L
F
R
-
G
L
A
D--
D
------
L
P
L
M
T
W
L
Q
E
------
H
V
W
P
A
E
A
----
Q
H
V
D
--
E
H
F
V
K
Q
G
T
E
L
A
I
A
E
M
I
Q
S
G
T
T
T
F
A
--
D
M
-----
Y
F
Y
P
-----------
Q
-----
Q
------
S
G
---
E
A
A
L
A
A
G
--
I
R
A
V
C
F
A
P
V
L
-
D
F
P
---------------
T
----
N
-----
Y
A
-----
Q
N
A
D
E
Y
I
R
K
A
-
I
E
C
N
D
R
F
N
N
HPMN
E
-----
Q
---
G
L
---
V
-
Q
I
G
F
G
P
H
A
P
-
Y
T
V
S
D
E
-
P
L
K
E
I
T
M
L
S
D
Q
L
-
D
M
P
--
V
Q
I
H
L
H
E
T
D
F
E
V
S
E
S
L
E
T
F
N
----
K
R
P
T
Q
R
L
A
D
I
G
F
L
N
E
-
R
-
V
S
C
V
H
M
T
Q
V
D
D
G
D
I
K
I
L
Q
K
T
G
A
S
I
I
H
C
P
E
S
N
L
K
L
A
S
G
F
C
P
I
A
K
L
S
A
A
N
I
P
L
A
I
G
T
D
-
G
A
A
S
N
N
-
D
L
D
M
F
------
S
E
T
K
T
A
A
---
L
L
A
K
G
---
V
----------
S
QDA
S
-------
A
I
P
A
-----
I
----
E
A
L
T
M
A
T
L
G
G
A
R
A
L
G
I
D
D
I
T
G
S
L
K
P
G
K
A
A
D
I
Q
A
I
D
L
N
T
--
L
S
S
Q
P
--------
V
F
D
P
V
S
-
H
M
V
Y
C
T
K
S
T
Q
V
S
H
V
W
V
N
G
R
C
L
L
K
N
G
---------------------------
8
PsiBlast_PDB
84.96
28%
-101
- C1 -
3HPA
1
?
A:
[29-415]
--------------------------------
K
-
T
-
L
L
V
K
H
A
D
V
L
V
T
M
D
D
T
R
R
E
L
R
D
A
G
L
Y
I
-
E
D
N
R
I
V
A
V
G
P
S
A
E
L
P
E
T
A
D
E
V
L
D
L
R
G
H
------
L
V
I
P
G
L
V
N
T
H
H
H
---
M
Y
-
Q
SLT
R
---
A
V
P
-
A
A
Q
---
N
------
A
E
L
F
G
W
L
T
N
L
Y
K
I
W
A
H
L
T
P
-------
E
M
I
E
--
V
S
T
L
T
A
M
A
E
L
-----
L
Q
S
G
C
T
T
S
S
D
H
L
Y
-----
I
Y
P
N
-----------
G
-----
S
--
R
L
D
D
S
I
---
G
A
A
Q
R
I
G
--
M
R
F
H
A
S
R
G
A
M
S--------------------------------------
E
P
D
I
L
R
D
T
-
Q
R
L
I
E
T
Y
H
-----
D
-----
E
---
G
R
YAM
L
-
R
V
V
V
A
P
C
S
P
-
F
S
V
S
R
D
-
L
M
R
D
A
A
V
L
A
R
E
Y
-
G
V
S
--
L
H
T
H
L
A
E
N
V
N
D
I
A
Y
-----------
T
P
A
E
Y
A
E
D
L
G
W
V
G
H
-
D
-
V
W
H
A
H
C
V
Q
L
D
D
A
G
I
G
L
F
A
R
T
G
T
G
V
A
H
C
P
C
S
N
M
R
L
A
S
G
I
A
P
V
K
K
M
R
L
A
G
V
P
V
G
L
G
V
D
G
S
A
S
N
-
D
-
G
A
Q
M
V
------
A
E
V
R
Q
A
L
---
L
L
Q
R
V
G
F-
G
----------
P
---
D
-------
A
M
T
A
-----
R
----
E
A
L
E
I
A
T
L
G
G
A
K
V
L
N
R
D
D
-
I
G
A
L
K
P
G
M
A
A
D
F
A
A
F
D
L
R
Q
--
P
L
F
A
G
A
L
H
D
P
V
A
A
L
V
F
C
A
P
-
S
Q
T
A
Y
T
V
V
N
G
K
V
V
V
R
E
G
R
L
A
T
L
D
L
P
---------------------------
85
HHSearch
83.50
21%
-89
- C1 -
2PAJ
1
IXPDE_UNKP
A:
[10-457]
------------------------
P
S
T
L
I
R
N
A
A
A
I
-
M
T
G
G
---
R
-
G
T
A
-
D
D
P
S
R
V
P
G
P
D
I
R
I
-
V
G
D
T
I
D
A
I
G
A
L
A
P
R
-----
P
G
E
T
I
V
D
A
---
T
D
C
V
I
Y
P
A
W
V
N
T
H
H
H
---
L
F
-
Q
---
S
---
L
L
K
-
G
E
P
-----------------------------
F
R
A
----
L
-
F
D
--
E
R
R
F
R
L
A
A
R
I
G
L
I
E
L
A
R
S
G
C
A
T
V
A
--
D
H
-----
N
Y
V
Y
YPGMP------
F
-----
D
--
S
S
A
I
L
F
---
E
E
A
E
K
L
G
--
L
R
F
V
L
L
R
G
G
A
-
T
Q
T
-------
R
Q
LEADLP
T
----
A
-----
L
R
P----
E
T
L
D
A
Y
V
A
D
I
-
E
R
L
A
A
R
Y
H
-----
D
-----
A
SPR
A
M
---
R
-
R
V
V
M
A
P
T
T
V
L
Y
S
I
S
P
R
-
E
M
R
E
T
A
A
V
A
R
R
L
-
G
L
R
--
M
H
S
H
L
S
-------------
G
----
K
S
P
V
A
F
C
G
E
H
D
W
L
G
S
-
D
-
V
W
Y
A
H
L
V
K
V
D
A
D
E
I
A
L
L
A
Q
T
G
T
G
V
A
H
C
P
Q
S
N
G
R
L
-----
P
V
R
E
M
A
D
A
G
V
P
V
S
I
G
V
D
-
G
A
A
S
-
N
E
A
A
D
M
I
------
S
E
V
H
M
T
W
---
L
A
Q
R
A
---
R
L----------------------
A
S
I
-----
A
----
E
V
I
H
W
G
T
A
G
G
A
R
V
M
G
L
D
-
E
V
G
K
V
A
V
G
Y
A
A
D
I
A
V
Y
R
L
D
D
--
P
R
Y
F
G
--------
L
H
D
P
A
I
-
G
P
V
A
S
G
G
R
P
S
V
M
A
L
F
S
A
G
K
R
V
V
V
D
D
---------------------------
7
PsiBlast_PDB
82.09
28%
-84
- C1 -
4GBD
3
?
A:
[70-394]
--------------------------------------------------------------------------------------
I
R
E
L
---
P
G
M
L
L
A
P
G
L
V
N
A
H
G
H
---
S
A
M
S
---
L
---
F
R
G
-
L
A
D
---
D
------
L
P
L
M
T
W
L
Q
D
------
H
I
W
P
A
E
G
----
Q
W
V
S
--
E
D
F
I
R
D
G
T
E
L
A
I
A
E
Q
V
K
G
G
I
T
C
-----
F
-----
S
D
M
Y
-----------------
F
--
Y
P
Q
A
I
C
---
G
V
V
H
D
S
G
--
V
R
A
Q
V
A
I
P
V
L
-
D
F
P
-------
I
P
------
G
----
A
------------
R
D
S
A
E
A
I
R
Q
G
-
M
A
L
F
D
D
L
K
-----
H
-----
H
---
P
R
---
I
-
R
I
A
F
G
P
H
A
P
-
Y
T
V
S
D
D
-
K
L
E
Q
I
L
V
L
T
E
E
L
-
D
A
S
--
I
Q
M
H
V
H
E
T
A
F
E
V
E
Q
A
M
E
R
--
N
--
G
E
R
P
L
A
R
L
H
R
L
G
L
L
G
P
-
R
-
F
Q
A
V
H
M
T
Q
V
D
N
D
D
L
A
M
L
V
E
T
N
S
S
V
I
H
C
P
E
S
N
L
K
L
A
S
G
F
C
P
V
E
K
L
W
Q
A
G
V
N
V
A
I
G
T
D
G
A
A
S
N
-
N
-
D
L
D
L
L
------
G
E
T
R
T
A
A
---
L
L
A
K
A
V
Y
G
Q
----------
A
---
T
-------
A
L
D
A
-----
H
----
R
A
L
R
M
A
T
L
N
G
A
R
A
L
G
L
E
R
L
I
G
S
L
E
A
G
K
A
A
D
L
V
A
F
D
L
S
G
--
L
A
Q
Q
P
V
Y
D
P
V
S
Q
L
I
Y
A
S
G
R
-
D
C
V
R
H
V
W
V
G
G
R
Q
L
L
D
D
G
R
L
L
R
H
D
E
Q
---------------------------
87
HHSearch
81.68
22%
-80
- C1 -
3MDU
4
?
A:
[2-432]
--------------------------
S
A
I
F
A
E
R
-
A
-
L
L
------------
P
E
G
W
A
R
N
V
R
F
E
I
S
A
D
G
V
L
A
E
I
R
P
D
A
N
--------
A
D
G
A
E
R
---
L
G
G
A
V
L
P
G
M
P
N
L
H
S
H
---
A
F
-
Q
---
R
---
A
M
A
-
G
L
A
---
E
VAGNPN
D
S
F
W
T
W
R
E
L
------
M
Y
-
R
M
V
A
----
R
-
L
S
--
P
E
Q
I
E
V
I
A
C
Q
L
Y
I
E
M
L
K
A
G
Y
T
A
V
A
--
E
F
-----
H
Y
V
H
HDLDGRSYADP
A
-----
E
--
L
S
L
R
I
S
---
R
A
A
S
A
A
G
--
I
G
L
T
L
L
P
V
L
Y
-
S
H
A
-------
G
F
------
G
GQPA
S
EGQRR
F
I
-----
N
G
S
E
A
Y
L
E
L
L
-
Q
R
L
R
A
P
L
------
E
-----
A
---
A
G
---
H
-
S
L
G
L
C
F
H
S
L
-
R
A
V
T
P
Q
-
Q
I
A
T
V
L
A
-
A
G
H
D
-
D
L
P
--
V
H
I
H
I
A
E
Q
Q
K
E
V
D
D
C
Q
A
W
S
G
----
R
R
P
L
Q
W
L
Y
E
N
V
A
V
D
Q
-
R
-
W
C
L
V
H
A
T
H
A
D
P
A
E
V
A
A
M
A
R
S
G
A
V
A
G
L
C
L
S
T
E
A
N
L
G
D
G
I
F
P
A
T
D
F
L
A
Q
G
G
R
L
G
I
G
S
D
-
S
H
V
----
S
L
S
V
V
------
E
E
L
R
W
L
E
---
Y
G
Q
R
L
---
R
D
RKRNRLYRD
D
---
Q
-------
P
M
I
G
-----
R
----
T
L
Y
D
A
A
L
A
G
G
A
Q
A
L
G
Q
--
P
I
G
S
L
A
V
G
R
R
A
D
L
L
V
L
D
G
N
D
--
P
Y
L
A
S
A
------
E
G
D
A
L
L
N
-
R
W
L
F
A
G
G
D
R
Q
V
R
D
V
M
V
A
G
R
W
V
V
R
D
G
---------------------------
6
PsiBlast_PDB
81.21
28%
-87
- C1 -
4DYK
4
?
A:
[56-380]
--------------------------------------------------------------------------------------
I
R
E
L
---
P
G
M
L
L
A
P
G
L
V
N
A
H
G
H
---
S
A
M
S
---
L
---
F
R
G
-
L
A
D
---
D
------
L
P
L
M
T
W
L
Q
D
------
H
I
W
P
A
E
G
----
Q
W
V
S
--
E
D
F
I
R
D
G
T
E
L
A
I
A
E
Q
V
K
G
G
I
T
C
-----
F
-----
S
D
M
Y
-----------------
F
--
Y
P
Q
A
I
C
---
G
V
V
H
D
S
G
--
V
R
A
Q
V
A
I
P
V
L
-
D
F
P
-------
I
P
------
G
----
A
------------
R
D
S
A
E
A
I
R
Q
G
-
M
A
L
F
D
D
L
K
-----
H
-----
H
---
P
R
---
I
-
R
I
A
F
G
P
H
A
P
-
Y
T
V
S
D
D
-
K
L
E
Q
I
L
V
L
T
E
E
L
-
D
A
S
--
I
Q
M
H
V
H
E
T
A
F
E
V
E
Q
A
M
E
R
--
N
--
G
E
R
P
L
A
R
L
H
R
L
G
L
L
G
P
-
R
-
F
Q
A
V
H
M
T
Q
V
D
N
D
D
L
A
M
L
V
E
T
N
S
S
V
I
H
C
P
E
S
N
L
K
L
A
S
G
F
C
P
V
E
K
L
W
Q
A
G
V
N
V
A
I
G
T
D
G
A
A
S
N
-
N
-
D
L
D
L
L
------
G
E
T
R
T
A
A
---
L
L
A
K
A
V
Y
G
Q
----------
A
---
T
-------
A
L
D
A
-----
H
----
R
A
L
R
M
A
T
L
N
G
A
R
A
L
G
L
E
R
L
I
G
S
L
E
A
G
K
A
A
D
L
V
A
F
D
L
S
G
--
L
A
Q
Q
P
V
Y
D
P
V
S
Q
L
I
Y
A
S
G
R
-
D
C
V
R
H
V
W
V
G
G
R
Q
L
L
D
D
G
R
L
L
R
H
D
E
Q
---------------------------
91
HHSearch
81.18
24%
-91
- C1 -
1P1M
2
MTAD_THEMA
A:
[2-382]
---------------------------
I
I
G
N
C
L
-
I
-
L
K
D
-----------
F
S
S
E
P
F
W
G
A
V
E
I
-
E
N
G
T
I
K
R
V
L
Q
G
E
--------
V
K
V
D
L
D
L
---
S
G
K
L
V
M
P
A
L
F
N
T
H
T
H
---
A
P
-
M
---
T
---
L
L
R
-
G
V
A
E--
D
------
L
S
F
E
E
W
L
F
S
------
K
V
L
P
I
E
D
----
R
L
-
T
--
E
K
M
A
Y
Y
G
T
I
L
A
Q
M
E
M
A
R
H
G
I
A
G
F
V
--
D
M
-----
Y
F
H
----------------------
E
E
W
I
A
---
K
A
V
R
D
F
G
--
M
R
A
L
L
T
R
G
L
V
-
D
S
N
-------
G
D
------
D
--------------------
G
G
R
L
E
E
N
-
L
K
L
Y
N
E
W
N
-----
G
F----
E
---
G
R
---
I
-
F
V
G
F
G
P
H
S
P
-
Y
L
C
S
E
E
-
Y
L
K
R
V
F
D
T
A
K
S
L
-
N
A
P
--
V
T
I
H
L
Y
E
T
S
K
E
E
-
Y
D
------------
L
E
D
I
L
N
I
G
L
K
E
V
-
K
-
T
I
A
A
H
C
V
H
L
P
E
R
Y
F
G
V
L
K
D
I
P
F
F
V
S
H
N
P
A
S
N
L
K
L
G
N
G
I
A
P
V
Q
R
M
I
E
H
G
M
K
V
T
L
G
T
D
-
G
A
A
S
N
N
-
S
L
N
L
F
------
F
E
M
R
L
A
S
---
L
L
Q
K
A
---
Q
N---------
P
---
R
-------
N
L
D
V
-----
N
----
T
C
L
K
M
V
T
Y
D
G
A
Q
A
M
G
F
K
--
S
G
K
I
E
E
G
W
N
A
D
L
V
V
I
D
L
D
L
--
P
E
M
F
P
V
--------
Q
N
I
K
N
-
H
L
V
H
A
-
F
S
G
E
V
F
A
T
M
V
A
G
K
W
I
Y
F
D
G
---------------------------
88
HHSearch
80.71
22%
-88
- C1 -
3LS9
1
?
A:
[18-434]
----------------------------------------------------
R
E
L
E
D
A
D
I
L
I
-
D
G
P
K
I
V
A
V
G
K
D
L
S
D
----
R
S
V
S
R
T
I
D
G
---
R
G
M
I
A
L
P
G
L
I
N
S
H
Q
H
---
L
Y
-
E
---
G
---
A
M
R
-
A
I
P
QLE
R
------
V
T
M
A
S
W
L
E
G
------
V
L
T
R
S
A
G
W
W
R
D
G
K
F
G
--
P
D
V
I
R
E
V
A
R
A
V
L
L
E
S
L
L
G
G
I
T
T
V
A
--
D
Q
-----
H
L
F
F
-----------
P
GATAD
S
--
Y
I
D
A
T
I
---
E
A
A
T
D
L
G
--
I
R
F
H
A
A
R
S
S
M
-
T
L
G
-------
K
S
E-----
G
----
G
-----
F
C
DDLFV
E
P
V
D
R
V
V
Q
H
C
-
L
G
L
I
D
Q
Y
H
EPE--
P
-----
F
---
G
M
---
V
-
R
I
A
L
G
P
C
G
V
-
P
Y
D
K
P
E
-
L
F
E
A
F
A
Q
M
A
A
D
Y
-
D
V
R
--
L
H
T
H
F
Y
E
P
L
D
A
-
G
M
S
D
H
L
Y
----
G
M
T
P
W
R
F
L
E
K
H
G
W
A
S
D
-
R
-
V
W
L
A
H
A
V
V
P
P
R
E
E
I
P
E
F
A
D
A
G
V
A
I
A
H
L
I
A
P
D
L
R
M
G
W
G
L
A
P
I
R
E
Y
L
D
A
G
I
T
V
G
F
G
T
T
-
G
S
A
S
N
D
-
G
G
N
L
L
------
G
D
L
R
L
A
A
---
L
A
H
R
P
---
A
DPNEP-----
E
---
K
-------
W
L
S
A
-----
R
----
E
L
L
R
M
A
T
R
G
S
A
E
C
L
G
R
P
-
D
L
G
V
L
E
E
G
R
A
A
D
I
A
C
W
R
L
D
G
--
V
D
R
V
G
--------
V
H
D
P
A
I
-
G
L
I
M
T
G
L
S
D
R
A
S
L
V
V
V
N
G
Q
V
L
V
E
N
E
---------------------------
5
PsiBlast_PDB
79.99
27%
-75
- C1 -
4DZH
7
?
A:
[67-423]
---------------------------------------------------------------------------------------------
P
D
A
A
L
M
P
G
L
V
N
A
H
T
H
---
N
P
-
M
---
T
LLR
G
V
---
A
D
---
D
------
L
P
L
M
V
W
L
Q
Q
------
H
I
W
P
V
E
A
----
A
V
I
G
--
P
E
F
V
A
D
G
T
T
L
A
I
A
E
M
L
R
G
G
T
T
---------------------------
C
-----
V
--
N
E
N
Y
F
F
A
D
V
Q
A
A
V
Y
K
Q
H
G
F
R
A
L
V
G
A
V
I
I
-
D
---------
F
P
------
T
----
A
-----
W
A
-----
S
S
D
D
E
Y
F
A
R
A
-
G
E
L
H
D
Q
W
R
-----
D
-----
D
---
P
L
---
I
-
S
T
A
F
A
P
H
-
A
-
P
Y
T
V
N
D
-
A
N
F
E
R
V
R
M
L
A
D
Q
L
D
M
P
--
V
H
L
H
T
H
E
T
A
Q
E
V
A
--
D
S
V
A
Q
Y
--
G
Q
R
P
L
A
R
L
D
R
L
G
L
V
N
D
-
R
-
L
I
A
V
H
M
T
Q
L
T
E
A
E
I
H
L
C
A
E
R
G
V
S
V
V
H
C
P
E
S
N
L
K
L
A
S
G
F
C
P
A
C
A
L
Q
R
A
S
V
N
L
A
I
G
T
D
G
C
A
S
N
-
N
-
D
L
D
M
F
------
S
E
N
R
T
A
A
---
I
L
A
K
A
V
A
N
D
----------
A
---
T
-------
A
L
D
A
-----
A
----
T
T
L
R
A
A
T
L
G
G
A
R
A
L
G
F
G
D
R
I
G
S
I
E
V
G
K
Q
A
D
L
V
C
V
D
L
S
A
----
L
E
T
Q
P
L
H
H
------
V
L
S
-
Q
L
I
Y
A
A
G
R
H
Q
V
T
D
V
W
I
A
G
K
P
K
L
V
Q
R
---------------------------
13
PsiBlast_PDB
78.95
27%
-89
- C1 -
3LNP
5
?
A:
[50-404]
--------------------------------------------------------
D
H
C
L
L
I
-
K
D
G
I
I
L
A
I
E
------
P
Q
S
S
C
Q
I
P
A
T
E
T
L
D
L
G
Q
Q
V
L
M
P
G
W
V
N
A
H
G
H
---
A
A
M
S
---
L
---
F
R
G
-
L
A
D
---
D
------
L
P
L
M
T
W
L
Q
E
------
H
V
W
P
A
E
A
----
Q
H
V
D
--
E
H
F
V
K
Q
G
T
E
L
A
I
A
E
M
I
Q
S
G
T
T
T
F
A
--
D
M
-----
Y
F
Y
P
-----------
Q
-----
Q
--
S
G
E
A
A
L
---
A
A
G
------
I
R
A
V
C
F
A
P
V
L
-
D
F
---------
P
------
T
----
N
-----
Y
A
-----
Q
N
A
D
E
Y
I
R
K
A
-
I
E
C
N
D
R
F
N
-----
N
HPMNE
Q
---
G
L
---
V
-
Q
I
G
F
G
P
H
A
P
-
Y
T
V
S
D
E
-
P
L
K
E
I
T
M
L
S
D
Q
L
-
D
M
P
--
V
Q
I
H
L
H
E
T
D
F
E
V
S
E
S
L
E
T
F
N
K
R
P
T
Q
R
L
A
D
I
----
G
F
L
N
E
-
R
-
V
S
C
V
H
M
T
Q
V
D
D
G
D
I
K
I
L
Q
K
T
G
A
S
I
I
H
C
P
E
S
N
L
K
L
A
S
G
F
C
P
I
A
K
L
S
A
A
N
I
P
L
A
I
G
T
D
---
G
A
-
A
-
S
N
N
D
L
------
D
M
F
S
E
T
K
---
T
A
A
L
L
A
--
K
----------
G
---
V
-------
S
Q
D
A
SAIP
A
I
----
E
A
L
T
M
A
T
L
G
G
A
R
A
L
G
I
D
D
I
T
G
S
L
K
P
G
K
A
A
D
I
Q
A
I
D
L
N
T
--
L
S
S
Q
P
V
F
D
P
V
S
H
M
V
Y
C
T
K
S
-
T
Q
V
S
H
V
W
V
N
G
R
C
L
L
K
N
G
E
L
T
T
L
N
E
E
---------------------------
114
Fugue
77.45
19%
-84
- C1 -
2PAJ
1
IXPDE_UNKP
A:
[10-484]
-----------
P
S
T
L
I
R
N
------------------
A
A
A
I
-
M
T
G
G
R
G
T
A
D
D
P
S
R
V
P
G
P
D
I
R
I
-
V
G
D
T
I
D
A
I
G
A
-----
L
A
P
R
P
G
E
T
I
V
D
A
---
T
D
C
V
I
Y
P
A
W
V
N
T
H
H
H
----------
L
---
F
Q
S
-
L
L
K
---
G
------
E
P
F
R
A
L
F
----------------------
D
--
E
R
R
F
R
L
A
A
R
I
G
L
I
E
L
A
R
S
G
C
A
T
V
A
--
D
H
NYVYY
P
G
M
P
-----------
F
-----
D
--
S
S
A
I
L
F
---
E
E
A
E
K
L
G
--
L
R
F
V
L
L
R
G
G
A
-
T
Q
T
RQLEADL
P
T
------
A
----
L
-----
R
P
-----
E
T
L
D
A
Y
V
A
D
I
-
E
R
L
A
A
R
Y
H
-----
D
ASP--
R
---
A
M
---
R
-
R
V
V
M
A
P
T
T
V
-
L
Y
S
I
S
P
-
R
E
M
R
E
T
A
A
V
A
R
R
L
G
L
R
--
M
H
S
H
L
S
G
K
-----------------
S
P
V
A
F
C
G
E
H
D
W
L
G
S
-
D
-
V
W
Y
A
H
L
V
K
V
D
A
D
E
I
A
L
L
A
Q
T
G
T
G
V
A
H
C
P
Q
S
N
G
-----
R
L
P
V
R
E
M
A
D
A
G
V
P
V
S
I
G
V
D
G
A
A
S
N
-
E
-
A
A
D
M
I
------
S
E
V
H
M
T
W
---
L
A
Q
R
A
---
R
----------
L
------------
A
S
I
-----
A
----
E
V
I
H
W
G
T
A
G
G
A
R
V
M
G
L
D
E
-
V
G
K
V
A
V
G
Y
A
A
D
I
A
V
Y
R
L
D
D
----------
P
R
Y
F
G
L
H
D
P
A
I
-
G
P
V
A
S
G
G
R
P
S
V
M
A
L
F
S
A
G
K
R
V
V
V
D
D
LIEGVD
I
K
E
L
G
G
E
A
R
R
V
V
R
E
L
L
R
E
V
V
V
14
PsiBlast_PDB
76.65
25%
-85
- C1 -
1P1M
2
MTAD_THEMA
A:
[2-351]
--------------------------------------
I
I
-
G
N
C
L
I
L
K
D
F
S
S
E
P
F
W
-
G
A
V
E
I
-
E
N
G
T
I
K
R
V
-----
L
Q
G
E
V
K
V
D
L
D
L
------
S
G
K
L
V
M
P
A
L
F
N
T
H
T
H
---
A
P
-
M
---
T
LLR
G
V
A
-
E
D
L
---
S
------
F
E
--
E
W
L
F
S
------
K
V
L
P
I
E
D
----
R
L
T
E
K
M
A
Y
Y
G
T
I
L
A
Q
M
---
E
M
A
R
H
G
-------
I
A
-----
G
F
V
D
-----------
M
-----
Y
--
F
H
E
E
W
I
A
--
K
A
V
R
D
F
G
--
M
R
A
L
L
T
R
G
L
V
-
D
S
N
-------
G
D
------
D
----
G
----------------
G
R
L
E
E
N
-
L
K
L
Y
N
E
W
N
-----
G
F----
E
---
G
R
---
I
-
F
V
G
F
G
P
H
S
P
-
Y
L
C
S
E
E
-
Y
L
K
---
R
V
F
D
T
A
K
S
L
N
A
P
V
T
I
H
L
Y
E
T
S
K
E
E
Y
-------
D
--
L
E
D
I
L
N
I
----
G
L
K
E
V
-
K
-
T
I
A
A
H
C
V
H
L
P
E
R
Y
F
G
V
L
K
D
I
P
F
F
V
S
H
N
P
A
S
N
L
K
L
G
N
G
I
A
P
V
Q
R
M
I
E
H
G
M
K
V
T
L
G
T
D
G
A
A
S
N
-
N
-
S
L
N
L
F
------
F
E
M
R
L
A
S
---
L
L
Q
K
A
---
Q
----------
N
P--
R
-------
N
L
D
V
-----
N
----
T
C
L
K
M
V
T
Y
D
G
A
Q
A
M
G
F
K
S
--
G
K
I
E
E
G
W
N
A
D
L
V
V
I
D
L
D
L
--
P
E
M
F
P
V
Q
N
I
K
N
H
L
V
H
A
F
S
G
-
E
V
F
A
T
M
V
A
G
K
W
I
Y
F
D
G
E
Y
P
T
I
D
S
E
E
---------------------------