@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4068: (2016-02-23 )
MFERPILITGGAGFIGSHLTDALLARGYRVRVLDNLSTGKRDNLPLDDERVELLEGDAADAATLAAALKGCAAVAHLAAVASVQASVDDPVATHQSNFIATLNLCEAMREQGVKRVVFASSAAVYGQNGEGTAIDEDTPKSPLTPYASDKLASEYYLDFYRRQHGLEPAIFRFFNVYGPRQDPSSPYSGVISIFTERALKGTPITVFGDGEQTRDFIYVADLVDFLVQALEATAVEPGAVNVGLNRSISLKQLLAEIGQVLGGLPPVTHADARAGDIRHSRANNERLLRRFRFDQPTPMGVGLARLLGR
Atome Classification :
(33 SA)
.........10........20......--.------.30......-..40...-.----.----.--------.-..-----------50---.........60.....--...--70--.--.......80........90........100.......110.-.......120-....---...130--------------......-----..140.......150.......160.--......170....--------...180----.....-----....190.......---200.-..--....-----.------.210.------......220...-....------230..---.....------.240..---.--....250.-------......260....-.----.-.270----.-----..--.....280.......290..-....-.300.......----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFER
P
I
L
I
TG
G
A
G
F
I
G
S
H
L
T
D
A
L
L
ARG--
Y
------
R
V
R
V
L
DNLS-TGK-RDN-L----P----L--------
D
-
D
E
-----------
R
----
V
E
L
LEGDA
A
D
A
A
T
L
A
A
--
A
L
K
--
G
C
--
A
--
A
V
A
H
L
A
A
V
A
S
V
QASVDDPVATHQSN
F
I
A
T
L
N
L
C
E
A
M
R
E
Q-G-V
K
R
V
V
F
ASS
A
-
A
V
YG---QNGEG---------------TAIDED-----TPKSPLTPYAS
D
K
L
A
S
E
Y
Y
L
D
F
Y
R
R
Q--HGL
E
P
A
I
F
R
F
F
N
V--------YGPR------QDPSS-----
P
Y
S
G
V
I
S
I
F
T
E
RAL---K--G-T
P
--
I
T
V
F-----G------DGEQ
T
------
R
D
F
I
Y
V
A
D
L
V
D
F
-
L
V
Q
A
------
L
E
-
A
T---AVEPG------
A
V
N
VGL---N--RSI
S
L
K
Q
L
-------
L
A
E
I
G
Q
V
LGGLPP-V----T-HA-D----A-----RA--GDIRHSRA
N
N
E
R
L
L
R
R
FRFD-QPTP-
M
G
V
G
L
A
R
L
LGR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.57
37%
-91
- C1 -
4ZRN
2
?
A:
[6-300]
-----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
N
L
S
-
S
G
K
-
V
E
N
-
L
--------------------
N
R
-----------
N
----
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
--
R
P
--
E
--
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
---
E
N
V
K
V
---------------
F
P
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
--------
Y
G
P
R
------
Q
D
P
Y
G
-----
E
-
A
G
V
V
A
I
F
T
E
R
M
L
---
R
--
G
-
E
E
--
V
H
I
F
-----
G
------
D
G
E
Y
V
------
R
D
Y
V
Y
V
D
D
V
V
R
A
-
N
L
L
A
------
M
E
-
K
G
---
D
N
E
--------
V
F
N
I
G
T
---
G
--
R
G
T
T
V
N
Q
L
-------
F
K
L
L
K
E
I
T
G
Y
D
K
E
-
P
----
V
-
Y
K
-
P
----
P
-----
R
K
--
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
-
L
E
E
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.77
37%
-90
- C1 -
4ZRN
2
?
B:
[6-300]
-----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
N
L
S
-
S
G
K
-
V
E
N
-
L
--------------------
N
R
-----------
N
----
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
IF
S
L
H
--
R
P
--
E
--
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
---
E
N
V
K
V
---------------
F
P
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
--------
Y
G
P
R
------
Q
D
P
Y
G
-----
E
-
A
G
V
V
A
I
F
T
E
R
M
L
---
R
--
G
-
E
E
--
V
H
I
F
-----
G
------
D
G
E
Y
V
------
R
D
Y
V
Y
V
D
D
V
V
R
A
-
N
L
L
A
------
M
E
-
K
G
---
D
N
E
--------
V
F
N
I
G
T
---
G
--
R
G
T
T
V
N
Q
L
-------
F
K
L
L
K
E
I
T
G
Y
D
K
E
-
P
----
V
-
Y
K
-
P
----
P
-----
R
K
--
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
-
L
E
E
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
79.26
31%
-93
- C1 -
1R6D
2
?
A:
[1-309]
---
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
-
Y
A
G
N
R
A
N
-
L
----
A
PV--
D
--------
A
-
D
P
-----------
R
----
L
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
--
E
L
R
--
G
V
--
D
--
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
N
-
Q
V
Y
G
---
S
I
D
S
G
----------------
S
W
T
E
S
-----
S
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
--
Y
G
L
D
V
R
I
T
R
C
C
N
N
--------
Y
G
P
Y
------
Q
H
P
---------
E
K
L
I
P
L
F
V
T
N
L
L
---
D
--
G
-
G
T
--
L
P
L
Y
-----
G
------
D
G
A
N
V
------
R
E
W
V
H
T
D
D
H
C
R
G
-
I
A
L
V
------
L
A
-
G
G
----
R
A
G
E
------
I
Y
H
I
G
G
---
G
--
L
E
L
T
N
R
E
L
-------
T
G
I
L
L
D
S
L
G
A
D
W
S
-
S
----
V
-
R
K
V
A
----
D
-----
R
K
--
G
H
D
L
R
Y
S
L
D
G
G
K
I
E
R
E
L
G
Y
R
-
P
Q
V
S
-
F
A
D
G
L
A
R
T
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
77.63
37%
-89
- C1 -
4ZRM
2
?
B:
[6-300]
-----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
N
L
S
-
S
G
K
-
V
E
N
-
L
--------------------
N
R
-----------
N
----
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
--
R
P
--
E
--
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
---
E
N
V
K
V
---------------
F
P
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
--------
Y
G
P
R
------
Q
D
P
Y
G
-----
E
-
A
G
V
V
A
I
F
T
E
R
M
L
---
R
--
G
-
E
E
--
V
H
I
F
-----
G
------
D
G
E
Y
V
------
R
D
Y
V
Y
V
D
D
V
V
R
A
-
N
L
L
A
------
M
E
-
K
G
---
D
N
E
--------
V
F
N
I
G
T
---
G
--
R
G
T
T
V
N
Q
L
-------
F
K
L
L
K
E
I
T
G
Y
D
K
E
-
P
----
V
-
Y
K
-
P
----
P
-----
R
K
--
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
-
L
E
E
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.04
37%
-88
- C1 -
4ZRM
3
?
A:
[6-300]
-----
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
I
E
N
G
--
Y
------
G
V
I
V
V
D
N
L
S
-
S
G
K
-
V
E
N
-
L
--------------------
N
R
-----------
N
----
A
L
F
Y
E
Q
S
I
E
D
E
E
M
M
E
R
I
F
S
L
H
--
R
P
--
E
--
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
S
I
K
Y
-
G
-
V
K
K
F
I
F
S
S
T
G
G
A
I
Y
G
---
E
N
V
K
V
---------------
F
P
T
P
E
T
-----
E
I
P
H
P
I
S
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
F
F
A
R
E
--
Y
G
L
K
Y
T
V
L
R
Y
A
N
V
--------
Y
G
P
R
------
Q
D
P
Y
G
-----
E
-
A
G
V
V
A
I
F
T
E
R
M
L
---
R
--
G
-
E
E
--
V
H
I
F
-----
G
------
D
G
E
Y
V
------
R
D
Y
V
Y
V
D
D
V
V
R
A
-
N
L
L
A
------
M
E
-
K
G
---
D
N
E
--------
V
F
N
I
G
T
---
G
--
R
G
T
T
V
N
Q
L
-------
F
K
L
L
K
E
I
T
G
Y
D
K
E
-
P
----
V
-
Y
K
-
P
----
P
-----
R
K
--
G
D
V
R
K
S
I
L
D
Y
T
K
A
K
E
K
L
G
W
E
-
P
K
V
S
-
L
E
E
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
75.46
28%
-93
- C1 -
2HUN
1
?
A:
[3-309]
--
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D
W
------
E
V
I
N
I
D
K
L
G
-
Y
G
S
N
P
A
N
-
L
----
K
----
D
LE------
D
-
D
P
-----------
R
----
Y
T
F
V
K
G
D
V
A
D
Y
E
L
V
K
E
--
L
V
R
--
K
V
--
D
--
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
P
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N
P
-
E
V
R
F
V
H
V
S
T
D
-
E
V
Y
G
---
D
I
L
K
G
----------------
S
F
T
E
N
-----
D
R
L
M
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
--
Y
N
L
N
A
S
I
T
R
C
T
N
N
--------
Y
G
P
Y
------
Q
F
P
---------
E
K
L
I
P
K
T
I
I
R
A
S
---
L
--
G
-
L
K
--
I
P
I
Y
-----
G
------
T
---
V
------
R
D
W
L
Y
V
E
D
H
V
R
A
-
I
E
L
V
------
L
L
-
K
G
----
E
S
R
E
------
I
Y
N
I
S
A
---
G
--
E
E
K
T
N
L
E
V
-------
V
K
I
I
L
R
L
M
G
K
G
E
E
-
L
----
I
E
L
V
-
E
----
D
-----
R
P
--
G
H
D
L
R
Y
S
L
D
S
W
K
I
T
R
D
L
K
W
R
-
P
K
Y
T
-
F
D
E
G
I
K
K
T
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
74.74
32%
-81
- C1 -
1SB8
2
?
A:
[25-345]
A
Q
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
------
K
V
V
G
L
D
N
F
A
-
T
G
H
-
Q
R
N
-
L
----
D
----
E
V
R
S
L
V
S
E
K
Q
-
W
S
-----------
N
----
F
K
F
I
Q
G
D
I
R
N
L
D
D
C
N
N
--
A
C
A
--
G
V
--
D
--
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
S
F
T
Y
A
A
S
S
-
S
T
Y
G
---
D
H
P
G
L
----------------
P
K
V
E
D
-----
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
--------
F
G
R
R
------
Q
D
P
N
G
-----
A
Y
A
A
V
I
P
K
W
T
S
S
M
I
---
Q
--
G
-
D
D
--
V
Y
I
N
-----
G
------
D
G
E
T
S
------
R
D
F
C
Y
I
E
N
T
V
Q
A
-
N
L
L
A
------
A
T
-
A
G
L--
D
A
R
N
Q
------
V
Y
N
I
A
V
---
G
--
G
R
T
S
L
N
Q
L
-------
F
F
A
L
R
D
G
L
A
E
N
G
V
S
Y
----
H
-
R
E
-
P
V
Y
R
D
F
-----
R
E
--
G
D
V
R
H
S
L
A
D
I
S
K
A
A
K
L
L
G
Y
A
-
P
K
Y
D
-
V
S
A
G
V
A
L
A
M
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
74.43
32%
-94
- C1 -
2C20
2
?
A:
[2-319]
---
N
S
I
L
I
C
G
G
A
G
Y
I
G
S
H
A
V
K
K
L
V
D
E
G
--
L
------
S
V
V
V
V
D
N
L
Q
-
T
G
H
-
E
D
A
-
I
--------------------
T
E
-----------
G
----
A
K
F
Y
N
G
D
L
R
D
K
A
F
L
R
D
--
V
F
T
Q
E
N
I
--
E
--
A
V
M
H
F
A
A
D
S
L
V
G
V
S
M
E
K
P
L
Q
Y
Y
N
N
N
V
Y
G
A
L
C
L
L
E
V
M
D
E
F
-
K
-
V
D
K
F
I
F
S
S
T
A
-
A
T
Y
G
---
E
V
D
V
D
----------------
L
I
T
E
E
-----
T
M
T
N
P
T
N
T
Y
G
E
T
K
L
A
I
E
K
M
L
H
W
Y
S
Q
A
--
S
N
L
R
Y
K
I
F
R
Y
F
N
V
--------
A
G
A
T
------
P
N
G
I
I
GEDHR
P
E
T
H
L
I
P
L
V
L
Q
V
A
L
---
G
Q-
R
-
E
K
--
I
M
M
F
-----
G
DDYNTP
D
G
T
C
I
------
R
D
Y
I
H
V
E
D
L
V
A
A
-
H
F
L
G
------
L
K
-
D
L
Q
N
-
G
G
E
S
D
------
F
Y
N
L
G
N
---
G
--
N
G
F
S
V
K
E
I
-------
V
D
A
V
R
E
V
T
N
H
E
I
P
-
A
----
E
-
V
A
-
P
----
R
-----
R
A
--
G
D
P
A
R
L
V
A
S
S
Q
K
A
K
E
K
L
G
W
D
-
P
R
Y
V
N
V
K
T
I
I
E
H
A
W
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.70
41%
-87
- C1 -
2P5U
1
?
B:
[3-286]
-----
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
N
L
A
-
T
G
K
-
R
E
N
-
V
----
P
----------------
K
-----------
G
----
V
P
F
F
R
V
D
L
R
D
K
E
G
V
E
R
--
A
F
R
--
E
F
RP
T
--
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
-
G
-
V
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
---
E
V
P
E
G
---------------
E
R
A
E
E
T
-----
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
--
Y
G
L
K
W
V
S
L
R
Y
G
N
V
--------
Y
G
P
R
------
Q
D
P
H
G
-----
E
-
A
G
V
V
A
I
F
A
E
R
V
L
---
K
--
G
-
L
P
--
V
T
L
Y
ARKTP
G
------
D
E
G
C
V
------
R
D
Y
V
Y
V
G
D
V
A
E
---
A
H
A
------
L
A
-
L
F
---
S
L
E
-
G
------
I
Y
N
V
G
T
---
G
--
E
G
H
T
T
R
E
V
-------
L
M
A
V
A
E
A
A
G
K
A
P
E
-
V
----
Q
-
P
A
-
P
----
P
-----
R
P
--
G
D
L
E
R
S
V
L
S
P
L
K
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
73.47
27%
-89
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
--
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
--
Y
------
D
C
V
V
A
D
N
L
S
-
N
S
T
-
Y
D
S
-
V
----
A
R
L
E
V
L
--------
T
-
K
H
-----------
H
----
I
P
F
Y
E
V
D
L
C
D
R
K
G
L
E
K
--
V
F
K
E
Y
K
I
--
D
--
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
P
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
-
N
-
V
S
K
F
V
F
S
S
S
A
-
T
V
Y
G
DAT
R
F
P
N
M
---------------
I
P
I
P
E
E
-----
C
P
L
G
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
K
K
S
W
K
F
A
I
L
R
Y
F
N
P
--------
I
G
A
H
PSGLIG
E
D
P
L
G
-----
I
P
N
N
L
L
P
Y
M
A
Q
V
A
V
---
G
--
R
-
R
E
K-
L
Y
I
F
-----
R
------
D
G
T
P
I
------
R
D
Y
I
H
V
V
D
L
A
K
G
-
H
I
A
A
------
L
Q
-
Y
L
---
E
A
Y
N
E
N
E
G
L
C
R
E
W
N
L
G
S
---
G
--
K
G
S
T
V
F
E
V
-------
Y
H
A
F
C
K
A
S
G
I
D
L
P
-
Y
----
V
-
L
N
---------------------
L
T
A
K
P
D
R
A
K
R
E
L
K
W
Q
-
T
E
L
Q
-
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
P
FGYQLRG
V
E
A
R
F
SAEDMRYDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
2
PsiBlast_PDB
73.41
41%
-81
- C1 -
2P5Y
1
?
A:
[3-286]
-----
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
N
L
A
-
T
G
K
-
R
E
N
-
V
----
P
----------------
K
-----------
G
----
V
P
F
F
R
V
D
L
R
D
K
E
G
V
E
R
--
A
F
R
--
E
F
RP
T
--
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
-
G
-
V
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
---
E
V
P
E
G
---------------
E
R
A
E
E
T
-----
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
--
Y
G
L
K
W
V
S
L
R
Y
G
N
V
--------
Y
G
P
R
------
Q
D
P
H
G
-----
E
-
A
G
V
V
A
I
F
A
E
R
V
L
---
K
--
G
-
L
P
--
V
T
L
Y
A
RKTP
G
------
D
E
G
C
V
------
R
D
Y
V
Y
V
G
D
V
A
E
---
A
H
A
------
L
A
-
L
F
---
S
L
E
-
G
------
I
Y
N
V
G
T
---
G
--
E
G
H
T
T
R
E
V
-------
L
M
A
V
A
E
A
A
G
K
A
P
E
-
V
----
Q
-
P
A
-
P
----
P
-----
R
P
--
G
D
L
E
R
S
V
L
S
P
L
K
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
72.12
33%
-87
- C1 -
1R66
3
?
A:
[3-306]
-----
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
Y
A
G
N
-
R
A
N
-
L
A---
P
----
V
--------
D
A
D
P
-----------
R
----
L
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
--
E
L
R
--
G
V
--
D
--
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
D
-
E
V
Y
G
---
S
I
D
S
G
---------------
S
W
T
-
E
S
-----
S
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
--
Y
G
L
D
V
R
I
T
R
C
C
N
N
--------
Y
G
P
Y
------
Q
H
P
E
K
---------
L
I
P
L
F
V
T
N
L
L
---
D
--
G
-
G
T
--
L
P
L
Y
-----
G
------
D
G
A
N
V
------
R
E
W
V
H
T
D
D
H
C
R
G
-
I
A
L
V
------
L
A
G
G
R
---
A
G
E
I
Y
------
H
I
G
G
G
L
ELT
N
--
R
E
L
T
-
G
I
L
-------
L
D
S
L
G
A
D
W
S
S
V
R
K
-
V
-------
A
-
D
----
R
-----
K
G
--
H
D
L
R
Y
S
-
L
D
G
G
K
I
E
R
E
L
G
Y
R
-
P
Q
V
S
-
F
A
D
G
L
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
72.05
33%
-86
* C1 *
1R6D
2
?
A:
[3-306]
-----
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
--
Y
PDVPAD
E
V
I
V
L
D
S
L
T
Y
A
G
N
-
R
A
N
-
L
A---
P
----
V
--------
D
A
D
P
-----------
R
----
L
R
F
V
H
G
D
I
R
D
A
G
L
L
A
R
--
E
L
R
--
G
V
--
D
--
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
A
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-
V
G
R
V
V
H
V
S
T
N
-
Q
V
Y
G
---
S
I
D
S
G
---------------
S
W
T
-
E
S
-----
S
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
--
Y
G
L
D
V
R
I
T
R
C
C
N
N
--------
Y
G
P
Y
------
Q
H
P
E
K
---------
L
I
P
L
F
V
T
N
L
L
---
D
--
G
-
G
T
--
L
P
L
Y
-----
G
------
D
G
A
N
V
------
R
E
W
V
H
T
D
D
H
C
R
G
-
I
A
L
V
------
L
A
G
G
R
---
A
G
E
I
Y
------
H
I
G
G
G
L
E
L
T
N
--
R
E
L
T
-
G
I
L
-------
L
D
S
L
G
A
D
W
S
S
V
R
K
-
V
-------
A
-
D
----
R
-----
K
G
--
H
D
L
R
Y
S
-
L
D
G
G
K
I
E
R
E
L
G
Y
R
-
P
Q
V
S
-
F
A
D
G
L
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
71.93
33%
-84
- C1 -
3VPS
2
?
A:
[7-300]
--
K
H
R
I
L
I
T
G
G
A
G
F
I
G
G
H
L
A
R
A
L
V
A
S
G
--
E
------
E
V
T
V
L
D
D
L
R
-
V
P
P
-
M
I
P
-
P
--------------------
E
G
-----------
T
----
G
K
F
L
E
K
P
V
L
E
L
E
--
E
R
--
D
L
S
--
D
V
--
R
--
L
V
Y
H
L
A
S
H
K
S
V
P
R
S
F
K
Q
P
-
L
D
Y
L
D
N
V
D
S
G
R
H
L
L
A
L
C
T
S
V
-
G
-
V
P
K
V
V
V
G
S
T
C
-
E
V
Y
G
---
Q
A
D
T
L
----------------
P
T
P
E
D
-----
S
P
L
S
P
R
S
P
Y
A
A
S
K
V
G
L
E
M
V
A
G
A
H
Q
R
A
S-
V
A
P
E
V
G
I
V
R
F
F
N
V
--------
Y
G
P
G
------
E
R
P
---------
D
A
L
V
P
R
L
C
A
N
L
L
---
T
--
R
-
N
E
--
L
P
V
E
-----
G
------
D
G
E
Q
R
------
R
D
F
T
Y
I
T
D
V
V
D
K
-
L
V
A
L
------
A
N
-
R
P
-----
L
P
S
------
V
V
N
F
G
S
---
G
--
Q
S
L
S
V
N
D
V
-------
I
R
I
L
Q
A
T
S
P
A
A
E
--
V
----
A
-
R
K
-
Q
----
P
-----
R
P
--
N
E
I
T
E
F
R
A
D
T
A
L
Q
T
R
Q
I
G
E
R
S
G
G
I
G
-
I
E
E
G
I
R
L
T
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.67
41%
-81
- C1 -
2P5U
1
?
D:
[3-286]
-----
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
N
L
A
-
T
G
K
-
R
E
N
-
V
----
P
----------------
K
-----------
G
----
V
P
F
F
R
V
D
L
R
D
K
E
G
V
E
R
--
A
F
R
--
E
F
RP
T
--
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
-
G
-
V
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
---
E
V
P
E
G
---------------
E
R
A
E
E
T
-----
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
--
Y
G
L
K
W
V
S
L
R
Y
G
N
V
--------
Y
G
P
R
------
Q
D
P
H
G
-----
E
-
A
G
V
V
A
I
F
A
E
R
V
L
---
K
--
G
-
L
P
--
V
T
L
Y
ARKTP
G
------
D
E
G
C
V
------
R
D
Y
V
Y
V
G
D
V
A
E
---
A
H
A
------
L
A
-
L
F
---
S
L
E
-
G
------
I
Y
N
V
G
T
---
G
--
E
G
H
T
T
R
E
V
-------
L
M
A
V
A
E
A
A
G
K
A
P
E
-
V
----
Q
-
P
A
-
P
----
P
-----
R
P
--
G
D
L
E
R
S
V
L
S
P
L
K
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
71.42
32%
-89
- C1 -
3KO8
2
?
A:
[1-304]
---
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
N
L
S
-
S
G
R
-
R
E
F
-
V
--------------------
N
P
-----------
S
----
A
E
L
H
V
R
D
L
K
D
Y
S
W
G
A
----
G
I
--
K
G
--
D
--
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
---
D
A
D
V
I
----------------
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
H
----------
G
V
I
Y
D
F
I
M
K
L
R
---
R
--
N
P
N
V
--
L
E
V
L
---------------
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
------
W
K
-
K
F
E
E
M
D
A
P
F
L
------
A
L
N
V
G
N
---
V
--
D
A
V
R
V
L
D
I
-------
A
Q
I
V
A
E
V
L
G
L
R
P
E
-
I
----
R
-
L
V
----------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
L
T
G
W
R
-
P
T
M
T
-
S
A
E
A
V
K
K
T
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.33
41%
-78
- C1 -
2P5U
1
?
C:
[3-286]
-----
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
N
L
A
-
T
G
K
-
R
E
N
-
V
----
P
----------------
K
-----------
G
----
V
P
F
F
R
V
D
L
R
D
K
E
G
V
E
R
--
A
F
R
--
E
F
RP
T
--
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
-
G
-
V
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
---
E
V
P
E
G
---------------
E
R
A
E
E
T
-----
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
--
Y
G
L
K
W
V
S
L
R
Y
G
N
V
--------
Y
G
P
R
------
Q
D
P
H
G
-----
E
-
A
G
V
V
A
I
F
A
E
R
V
L
---
K
--
G
-
L
P
--
V
T
L
Y
ARKTP
G
------
D
E
G
C
V
------
R
D
Y
V
Y
V
G
D
V
A
E
---
A
H
A
------
L
A
-
L
F
---
S
L
E
-
G
------
I
Y
N
V
G
T
---
G
--
E
G
H
T
T
R
E
V
-------
L
M
A
V
A
E
A
A
G
K
A
P
E
-
V
----
Q
-
P
A
-
P
----
P
-----
R
P
--
G
D
L
E
R
S
V
L
S
P
L
K
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.76
41%
-80
- C1 -
2P5U
1
?
A:
[3-286]
-----
V
L
V
T
G
G
A
G
F
I
G
S
H
I
V
E
D
L
L
A
R
G
--
L
------
E
V
A
V
L
D
N
L
A
-
T
G
K
-
R
E
N
-
V
----
P
----------------
K
-----------
G
----
V
P
F
F
R
V
D
L
R
D
K
E
G
V
E
R
--
A
F
R
--
E
F
RP
T
--
H
V
S
H
Q
A
A
Q
A
S
V
K
V
S
V
E
D
P
V
L
D
F
E
V
N
L
L
G
G
L
N
L
L
E
A
C
R
Q
Y
-
G
-
V
E
K
L
V
F
A
S
T
G
G
A
I
Y
G
---
E
V
P
E
G
---------------
E
R
A
E
E
T
-----
W
P
P
R
P
K
S
P
Y
A
A
S
K
A
A
F
E
H
Y
L
S
V
Y
G
Q
S
--
Y
G
L
K
W
V
S
L
R
Y
G
N
V
--------
Y
G
P
R
------
Q
D
P
H
G
-----
E
-
A
G
V
V
A
I
F
A
E
R
V
L
---
K
--
G
-
L
P
--
V
T
L
Y
A
RKTP
G
------
D
E
G
C
V
------
R
D
Y
V
Y
V
G
D
V
A
E
---
A
H
A
------
L
A
-
L
F
---
S
L
E
-
G
------
I
Y
N
V
G
T
---
G
--
E
G
H
T
T
R
E
V
-------
L
M
A
V
A
E
A
A
G
K
A
P
E
-
V
----
Q
-
P
A
-
P
----
P
-----
R
P
--
G
D
L
E
R
S
V
L
S
P
L
K
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
70.60
27%
-80
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-334]
---
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
G
--
I
------
D
L
I
V
F
D
N
L
S
-
R
K
G
-
A
T
D
N
L
----
H
W
L
--
S
--------
S
-
L
G
-----------
N
----
F
E
F
V
H
G
D
I
R
N
K
N
D
V
T
R
--
L
I
T
K
Y
M
P
--
D
--
S
C
F
H
L
A
G
Q
V
A
M
T
T
S
I
D
N
P
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
-
N
S
N
C
N
I
I
Y
S
S
T
N
-
K
V
Y
G
---
D
L
E
Q
Y
K
Y
N
E
T
ETRYTCVDKP
N
G
Y
D
E
S
-----
T
Q
L
D
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
--
F
G
L
N
T
V
V
F
R
H
S
S
M
--------
Y
G
G
R
------
Q
F
A
T
Y
-----
D
-
Q
G
W
V
G
W
F
C
Q
K
A
V
E
I
K
N
GI
N
-
K
P
--
F
T
I
S
-----
G
------
N
G
K
Q
V
------
R
D
V
L
H
A
E
D
M
I
S
L
-
Y
F
T
A
------
L
A
-
N
V
S--
K
I
R
G
N
------
A
F
N
I
G
G
---
T
IV
N
S
L
S
L
L
E
L
-------
F
K
L
L
E
D
Y
C
N
I
D
M
R
-
F
----
T
-
N
L
-
P
----
V
-----
R
E
--
S
D
Q
R
V
F
V
A
D
I
K
K
I
T
N
A
I
D
W
S
-
P
K
V
S
-
A
K
D
G
V
Q
K
M
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.09
33%
-87
- C1 -
3RUD
2
GNE_PLESH
A:
[26-328]
---
K
T
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
K
L
L
K
L
N
--
Q
------
V
V
I
G
L
D
N
F
S
-
T
G
H
-
Q
Y
N
-
L
--------------------
D
E
V
K
T
L
V
S
T
E
Q
W
S
R
----
F
C
F
I
E
G
D
I
R
D
L
T
T
C
E
Q
--
V
M
K
--
G
V
--
D
--
H
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
V
D
P
I
T
T
N
A
T
N
I
T
G
F
L
N
I
L
H
A
A
K
N
A
-
Q
-
V
Q
S
F
T
Y
A
A
S
S
-
S
T
Y
G
---
D
H
P
A
L
---------------
P
K
V
E
E
N
-----
I
-
G
N
P
L
S
P
Y
A
V
T
K
Y
V
N
E
I
Y
A
Q
V
Y
A
R
T
--
Y
G
F
K
T
I
G
L
R
Y
F
N
V
--------
F
G
R
R
------
Q
D
P
N
G
-----
A
Y
A
A
V
I
P
K
W
T
A
A
M
L
---
K
--
G
-
D
D
--
V
Y
I
N
-----
G
------
D
G
E
T
S
------
R
D
F
C
Y
I
D
N
V
I
Q
M
N
I
L
S
A
------
L
A
-
K
D
---
S
A
K
D
N
------
I
Y
N
V
A
V
---
G
--
D
R
T
T
L
N
E
L
-------
S
---
G
Y
I
Y
D
E
L
N
L
-
I
----
H
-
H
I
-------
K
Y
R
E
F
R
S
--
G
D
V
R
H
S
Q
A
D
V
T
K
A
I
D
L
L
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.78
34%
-87
- C1 -
4WOK
2
?
A:
[11-295]
--
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
--
Y
------
A
P
V
V
Y
D
N
L
S
-
T
G
H
-
Q
S
A
-
V
----
R
----
W
--------
G
-
D
-------------------
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
--
T
M
E
--
K
Y
--
A
PV
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
-
R
-
T
Q
N
V
I
F
S
S
S
C
-
A
T
Y
G
---
V
P
S
R
----------------
L
P
I
G
E
G
-----
E
A
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
--
Y
G
L
R
Y
V
A
L
R
Y
F
N
A
S
G
A
DIDGE
L
G
E
K
------
H
D
P
E
T
-----
H
L
--
I
P
R
A
M
M
A
A
A
G
---
R
--
L
-
D
V
--
L
E
V
Y
-----
G
------
D
D
Y
E
T
PDG
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
-
H
V
L
A
------
V
E
-
H
L
---
K
E
A
G
G
N
L
----
A
V
N
L
G
T
---
G
--
R
G
T
S
I
R
E
I
-------
V
Q
S
I
G
R
L
T
G
R
S
V
P
-
V
----
A
-
M
R
-
A
----
R
-----
R
A
--
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
67.37
34%
-89
- C1 -
4TWR
2
?
A:
[11-295]
--
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
--
Y
------
A
P
V
V
Y
D
N
L
S
-
T
G
H
-
Q
S
A
-
V
----
R
----
W
--------
G
-
D
-------------------
F
V
E
G
D
I
L
D
Q
A
R
L
V
E
--
T
M
E
--
K
Y
--
A
PV
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
-
R
-
T
Q
N
V
I
F
S
S
S
C
-
A
T
Y
G
---
V
P
S
R
----------------
L
P
I
G
E
G
-----
E
A
Q
N
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
--
Y
G
L
R
Y
V
A
L
R
Y
F
N
A
S
G
A
DIDGE
L
G
E
K
------
H
D
P
E
T
-----
H
L
--
I
P
R
A
M
M
A
A
A
G
---
R
--
L
-
D
V
--
L
E
V
Y
-----
G
------
D
D
Y
E
T
PDG
T
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
-
H
V
L
A
------
V
E
-
H
L
---
K
E
A
G
G
N
L
----
A
V
N
L
G
T
---
G
--
R
G
T
S
I
R
E
I
-------
V
Q
S
I
G
R
L
T
G
R
S
V
P
-
V
----
A
-
M
R
-
A
----
R
-----
R
A
--
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.96
35%
-101
- C1 -
3EHE
1
?
A:
[4-264]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
-
S
E
S
--
N
------
E
I
V
V
I
D
N
L
S
-
S
G
----
N
-
E
----
E
----
F
--------
V
-
N
E
-----------
A
----
A
R
L
V
K
A
D
L
A
-
A
D
D
I
K
D
--
Y
L
K
--
G
A
--
E
--
E
V
W
H
I
A
A
N
P
D
V
R
-
G
A
E
N
P
D
E
I
Y
R
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
-
G
-
V
S
R
I
V
F
T
S
T
S
-
T
V
Y
G
---
E
-
A
K
V
---------------
I
P
T
P
E
D
-----
Y
P
T
H
P
I
S
L
Y
G
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
H
T
--
F
D
M
Q
A
W
I
Y
R
F
A
N
V
--------
I
G
R
R
------
S
T
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
K
--
R
-
N
P
E
E
L
E
I
L
-----
G
------
N
G
E
Q
N
------
K
S
Y
I
Y
I
S
D
C
V
D
A
-
M
L
F
G
------
L
R
-
G
D
---
E
-
R
V
N
------
I
F
N
I
G
S
---
E
--
D
Q
I
K
V
K
R
I
-------
A
E
I
V
C
E
E
L
G
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
63.68
35%
-98
- C1 -
3EHE
1
?
B:
[4-264]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
-
S
E
S
--
N
------
E
I
V
V
I
D
N
L
S
-
S
G
----
N
-
E
----
E
----
F
--------
V
-
N
E
-----------
A
----
A
R
L
V
K
A
D
L
A
-
A
D
D
I
K
D
--
Y
L
K
--
G
A
--
E
--
E
V
W
H
I
A
A
N
P
D
V
R
-
G
A
E
N
P
D
E
I
Y
R
N
N
V
L
A
T
Y
R
L
L
E
A
M
R
K
A
-
G
-
V
S
R
I
V
F
T
S
T
S
-
T
V
Y
G
---
E
-
A
K
V
---------------
I
P
T
P
E
D
-----
Y
P
T
H
P
I
S
L
Y
G
A
S
K
L
A
C
E
A
L
I
E
S
Y
C
H
T
--
F
D
M
Q
A
W
I
Y
R
F
A
N
V
--------
I
G
R
R
------
S
T
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
K
--
R
-
N
P
EE
L
E
I
L
-----
G
------
N
G
E
Q
N
------
K
S
Y
I
Y
I
S
D
C
V
D
A
-
M
L
F
G
------
L
R
-
G
D
---
E
-
R
V
N
------
I
F
N
I
G
S
---
E
--
D
Q
I
K
V
K
R
I
-------
A
E
I
V
C
E
E
L
G
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.18
35%
-82
- C1 -
1SB9
2
?
A:
[31-320]
------
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
------
K
V
V
G
L
D
N
F
A
-
T
G
H
-
Q
R
N
-
L
D
E
V
R
S
----
L
--------
V
-
S
E
-----------
K
Q
W
S
N
F
K
F
I
Q
G
D
I
R
N
L
D
D
C
N
N
--
A
C
A
--
G
V
--
D
--
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
S
F
T
Y
A
A
S
S
-
S
T
Y
G
---
D
H
-
P
G
---------------
L
P
K
V
E
D
-----
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
--------
F
G
R
R
------
Q
D
P
N
G
-----
A
Y
A
A
V
I
P
K
W
T
S
S
M
I
---
Q
--
G
-
D
D
--
V
Y
I
N
-----
G
------
D
G
E
T
S
------
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
------
T
A
-
G
L
---
D
A
R
N
Q
------
V
Y
N
I
A
V
---
G
--
G
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
S
Y
H
R
E
P
-------
V
-
Y
R
-
D
----
F
-----
R
E
--
G
D
V
R
H
S
L
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.38
35%
-78
- C1 -
1SB8
2
?
A:
[31-320]
------
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
--
Q
------
K
V
V
G
L
D
N
F
A
-
T
G
H
-
Q
R
N
-
L
D
E
V
R
S
----
L
--------
V
-
S
E
-----------
K
Q
W
S
N
F
K
F
I
Q
G
D
I
R
N
L
D
D
C
N
N
--
A
C
A
--
G
V
--
D
--
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
P
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-
V
Q
S
F
T
Y
A
A
S
S
-
S
T
Y
G
---
D
H
-
P
G
---------------
L
P
K
V
E
D
-----
T
I
G
K
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
--
Y
G
F
S
T
I
G
L
R
Y
F
N
V
--------
F
G
R
R
------
Q
D
P
N
G
-----
A
Y
A
A
V
I
P
K
W
T
S
S
M
I
---
Q
--
G
-
D
D
--
V
Y
I
N
-----
G
------
D
G
E
T
S
------
R
D
F
C
Y
I
E
N
T
V
Q
A
N
L
L
A
A
------
T
A
-
G
L
---
D
A
R
N
Q
------
V
Y
N
I
A
V
---
G
--
G
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
S
Y
H
R
E
P
-------
V
-
Y
R
-
D
----
F
-----
R
E
--
G
D
V
R
H
S
L
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
59.27
37%
-107
- C1 -
4GLL
3
UXS1_HUMAN
A:
[8-241]
-----
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
D
G
--
H
------
E
V
T
V
V
D
N
F
F
-
T
G
R
-
K
R
N
-
V
----
E
HW--
I
--------
G
-
H
E
-----------
N
----
F
E
L
I
N
H
D
V
V
E
P
L
Y
I
E
---------
V
--
D
--
Q
I
Y
H
L
A
S
P
A
S
P
P
N
Y
M
Y
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
-
G
-
A
-
R
L
L
L
A
S
T
S
-
E
V
Y
G
----
D
P
E
V
---------------
H
P
Q
S
E
D
YW
G
H
V
N
P
I
G
P
R
A
C
Y
D
E
G
K
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
--
E
G
V
E
V
R
V
A
R
I
F
N
T
--------
F
G
P
R
------
M
H
M
N
D
-------
G
R
V
V
S
N
F
I
L
Q
A
L
---
Q
--
G
-
E
P
--
L
T
V
Y
-----
G
------
S
G
S
Q
T
------
R
A
F
Q
Y
V
S
D
L
V
N
G
-
L
V
A
L
------
M
N
-
S
N
---
V
S
S
P
--------
V
N
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
59.20
34%
-81
- C1 -
3KO8
2
?
A:
[3-285]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
N
L
S
-
S
G
R
-
R
E
F
-
V
--------------------
N
P
-----------
S
----
A
E
L
H
V
R
D
L
K
D
-
Y
S
W
G
A
--
G
I
K
--
G
---
D
--
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
----
D
A
D
V
---------------
I
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
R
--
R
-
N
P
N
V
L
E
V
L
---------------
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
W
K
K
F
E
E
M
D
-
A
P
---
F
L
A
L
N
------
V
G
N
V
D
A
---
V
--
R
V
L
D
I
A
Q
I
-------
V
A
E
---
V
L
G
L
R
P
E
-
I
R
L
V---------------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
59.18
37%
-113
- C1 -
4GLL
3
UXS1_HUMAN
B:
[8-241]
-----
I
L
I
T
G
G
A
G
F
V
G
S
H
L
T
D
K
L
M
M
D
G
--
H
------
E
V
T
V
V
D
N
F
F
-
T
G
R
-
K
R
N
-
V
----
E
HW--
I
--------
G
-
H
E
-----------
N
----
F
E
L
I
N
H
D
V
V
E
P
L
Y
I
E
---------
V
--
D
--
Q
I
Y
H
L
A
S
P
A
S
P
-----
N
P
I
K
T
L
K
T
N
T
I
G
T
L
N
M
L
G
L
A
K
R
V
-
G
-
A
-
R
L
L
L
A
S
T
S
-
E
V
Y
G
----
D
P
E
V
---------------
H
P
Q
S
E
D
YWGHV
N
P
I
G
P
R
A
C
Y
D
E
G
K
R
V
A
E
T
M
C
Y
A
Y
M
K
Q
--
E
G
V
E
V
R
V
A
R
I
F
N
T
--------
F
G
P
R
------
M
H
M
N
D
-------
G
R
V
V
S
N
F
I
L
Q
A
L
---
Q
--
G
-
E
P
--
L
T
V
Y
-----
G
------
S
G
S
Q
T
------
R
A
F
Q
Y
V
S
D
L
V
N
G
-
L
V
A
L
------
M
N
-
S
N
---
V
S
S
P
--------
V
N
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.58
34%
-77
- C1 -
3ICP
2
?
A:
[3-285]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
N
L
S
-
S
G
R
-
R
E
F
-
V
--------------------
N
P
-----------
S
----
A
E
L
H
V
R
D
L
K
D
-
Y
S
W
G
A
--
G
I
K
--
G
---
D
--
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
----
D
A
D
V
---------------
I
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
R
--
R
-
N
P
NV
L
E
-----------------
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
W
K
K
F
E
E
M
D
-
A
P
---
F
L
A
L
N
------
V
G
N
V
D
A
---
V
--
R
V
L
D
I
A
Q
I
-------
V
A
E
---
V
L
G
L
R
P
E
-
I
R
L
V---------------------
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
54.13
33%
-78
- C1 -
3AW9
2
?
A:
[3-281]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
I
V
----
Q
-
R
D
T
----------------------
G
G
-----------
S
----
A
E
L
H
V
R
D
L
K
D
Y
-
S
W
G
A
--
G
I
K
--
G
---
D
--
V
V
F
H
F
A
A
N
P
E
V
R
--
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
----
D
A
D
V
---------------
I
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
R
--
R
-
N
P
N
V
L
E
V
L
-----
G
------
D
G
T
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
W
K
K
F
E
E
M
D
-
A
P
---
F
L
A
L
N
------
V
G
N
V
D
A
---
V
--
R
V
L
D
I
A
Q
I
-------
V
A
E
---
V
L
G
L
R
P
E
-
I
R
L
V
P
S
-
T
P
-
D
----
G
-----
R
G
WP
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
53.46
33%
-81
- C1 -
3AW9
2
?
B:
[3-281]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
I
V
----
Q
-
R
D
-----------------------------------------
A
E
L
H
V
R
D
L
K
D
Y
-
S
W
G
A
--
G
I
K
--
G
---
D
--
V
V
F
H
F
A
A
N
P
E
V
R
--
T
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
----
D
A
D
V
---------------
I
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
R
--
R
-
N
P
N
V
L
E
V
L
-----
G
------
D
G
T
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
W
K
K
F
E
E
M
D
-
A
P
---
F
L
A
L
N
------
V
G
N
V
D
A
---
V
--
R
V
L
D
I
A
Q
I
-------
V
A
E
---
V
L
G
L
R
P
E
-
I
R
L
V
P
S
-
T
P
-
D
----
G
-----
R
G
WP
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
51.10
33%
-80
- C1 -
3AW9
2
?
C:
[3-281]
-----
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
--
Y
------
E
V
V
V
V
D
I
V
----
Q
-
R
D
-----------------------------------------
A
E
L
H
V
R
D
L
K
D
Y
-
S
W
G
A
--
G
I
K
--
G
---
D
--
V
V
F
H
F
A
A
N
P
E
V
R
---
T
E
P
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-
V
R
T
V
V
F
A
S
S
S
-
T
V
Y
G
----
D
A
D
V
---------------
I
P
T
P
E
E
-----
E
P
Y
K
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
--
F
G
V
R
C
L
A
V
R
Y
A
N
V
--------
V
G
P
R
------
L
R
----------
H
G
V
I
Y
D
F
I
M
K
-
L
---
R
--
R
-
N
P
N
V
L
E
V
L
-----
G
------
D
G
T
Q
R
------
K
S
Y
L
Y
V
R
D
A
V
E
A
-
T
L
A
A
W
K
K
F
E
E
M
D
-
A
P
---
F
L
A
L
N
------
V
G
N
V
D
A
---
V
--
R
V
L
D
I
A
Q
I
-------
V
A
E
---
V
L
G
L
R
P
E
-
I
R
L
V
P
S
-
T
P
-
D
----
G
-----
R
G
WP
G
D
V
K
Y
M
T
L
A
V
T
K
L
M
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------