@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKA1: (2017-10-25 )
MLFSGSSMSEQIFIQGPVGKIELFVDRPEGEIKGFAVVCHPHPLQGGTPQHKVPALLTQIFNEYGCIVYRPSFRGLGGSEGVHDEGHGETEDILAVIEHVRKLHAGLPFYAGGFSFGSHVLAKCHAQLSPELQPVQLILCGLPTATVVGLRHYKTPEIQGDILLIHGEQDDITLLSDAIEWAKPQKHPITILSGANHFFTGYLKQLRQIITRFIIMK
Atome Classification :
(20 SA)
.........10.....-...--20........--30--..-..---..-...40........50........60........70........80....-------.--...90........100.-..-....110.....--..120.....-----.-.130.......140..--.....------------------------------150---------------------------------.-----------------------------------.------------------.-------------------------------------.---.----.----...160-------------------........170......---.180.-.--.-----..-.--.---190.......200.----..-....210.....-----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLFSGSSMS
E
Q
I
F
I
QG-PV
G
--
K
I
E
L
F
V
DRPE--G---EI-
K
G
---
F
A
-
V
V
CHPHPLQGGTPQ
H
K
V
P
A
L
L
T
Q
I
F
N
EYG
C
I
V
YRPSFRGLGGSEGVHDE-------G--HG
E
T
E
D
I
L
A
V
I
E
H
V
R
K
L
-HA-GLPFYAGG
F
S
F
G
--
S
H
V
L
A
K
C
H
A
Q-----L-SPEL
Q
P
V
Q
L
I
L
CGL
P
T
--
A
T
V
VG------------------------------L-----------------------------------R-----------------------------------H------------------Y-------------------------------------K---T----P----EIQG
D
--------------------
I
L
L
I
HGEQD
D
I
T
L
L
S
D
A
---
I
E
WAK-P--Q-----KH-
P
--
I
---
T
I
LSG
A
N
H
F
F
T
G
Y
L
----
K
Q
-
L
R
Q
I
I
T
R
F
IIMK-----
29
Fugue
89.56
34%
-49
- C2 -
-
3TRD
-
?
A:
[1-208]
---
S
Y
V
M
T
N
E
D
F
L
I
Q
G
-
P
V
G
--
Q
L
E
V
M
I
T
R
P
K
--
G
---
I
E
K
S
V
---
T
G
-
I
I
C
H
P
H
P
L
H
G
G
T
M
N
N
K
V
V
T
T
L
A
K
A
L
D
E
L
G
L
K
T
V
R
F
N
F
R
G
V
G
K
S
Q
G
R
Y
D
N
-------
G
--
V
G
E
V
E
D
L
K
A
V
L
R
W
V
E
H
H
-
W
S
-
Q
D
D
I
W
L
A
G
F
S
F
G
--
A
Y
I
S
A
K
V
A
Y
D
-----
Q
-
K
V
A
----
Q
L
I
S
V
A
P
P
-----
V
F
Y
------------------------------
E
-----------------------------------
G
-----------------------------------
F
------------------
A
-------------------------------------
S
---
L
----
T
----
Q
M
A
S
P
--------------------
W
L
I
V
Q
G
D
Q
D
E
V
V
P
F
E
Q
V
---
K
A
F
V
N
-
Q
--
I
-----
S
S
-
P
VE
F
---
V
V
M
S
G
A
S
H
F
F
H
G
R
L
----
I
E
-
L
R
E
L
L
V
R
N
L
A
-------
14
HHSearch
88.81
33%
-51
- C2 -
-
3TRD
-
?
A:
[3-208]
-----
V
M
T
N
E
D
F
L
I
Q
G
-
P
V
G
--
Q
L
E
V
M
I
T
R
P
K
G-
I
---
E
K
-
S
V
---
T
G
-
I
I
C
H
P
H
P
L
H
G
G
T
M
N
N
K
V
V
T
T
L
A
K
A
L
D
E
L
G
L
K
T
V
R
F
N
F
R
G
V
G
K
S
Q
G
R
Y
D
N
-------
G
--
V
G
E
V
E
D
L
K
A
V
L
R
W
V
E
H
H
-
W
S
-
Q
D
D
I
W
L
A
G
F
S
F
G
--
A
Y
I
S
A
K
V
A
Y
--------
D
Q
--
K
V
A
Q
L
I
S
V
A
P
P
V
--
F
Y
E
G
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
S
----
L
T---
Q
M
A
S
P
--------------------
W
L
I
V
Q
G
D
Q
D
E
V
V
P
F
E
Q
V
---
K
A
F
V
N
-
Q
I-
S
S----
P
V
-
E
--
F
---
V
V
M
S
G
A
S
H
F
F
H
G
R
L
----
I
E
-
L
R
E
L
L
V
R
N
L
A
-------
30
Fugue
82.01
29%
-35
- C2 -
-
2FUK
-
?
A:
[3-220]
-
N
P
L
F
P
T
E
S
A
A
L
T
L
D
G
-
P
V
G
--
P
L
D
V
A
V
D
L
P
E
--
P
DVA
V
Q
-
P
V
---
T
A
-
I
V
C
H
P
L
S
T
E
G
G
S
M
H
N
K
V
V
T
M
A
A
R
A
L
R
E
L
G
I
T
V
V
R
F
N
F
R
S
V
G
T
S
A
G
S
F
D
H
-------
G
--
D
G
E
Q
D
D
L
R
A
V
A
E
W
V
R
A
Q
-
R
P
-
T
D
T
L
W
L
A
G
F
S
F
G
--
A
Y
V
S
L
R
A
A
A
A
-----
L
-
E
P
Q
----
V
L
I
S
I
A
P
P
------
A
G
------------------------------
R
-----------------------------------
W
-----------------------------------
D
------------------
F
-------------------------------------
S
---
D
----
V
----
Q
P
P
A
Q
--------------------
W
L
V
I
Q
G
D
A
D
E
I
V
D
P
Q
A
V
---
Y
D
W
L
E
-
T
--
L
-----
E
Q
-
Q
P
T
L
---
V
R
M
P
D
T
S
H
F
F
H
R
K
L
----
I
D
-
L
R
G
A
L
Q
H
G
V
R
R
W
LPATP
1
PsiBlast_PDB
79.29
33%
-30
- C2 -
-
3TRD
-
?
A:
[6-205]
--------
N
E
D
F
L
I
Q
G
-
P
V
G
--
Q
L
E
V
M
I
T
R
P
K
--
G
---
I
E
-
K
S
---
V
T
G
I
I
C
H
P
H
P
L
H
G
G
T
M
N
N
K
V
V
T
T
L
A
K
A
L
D
E
L
G
L
K
T
V
R
F
N
F
R
G
V
G
K
S
Q
G
R
Y
D
N
-------
G
--
V
G
E
V
E
D
L
K
A
V
L
R
W
V
E
H
H
-
W
S
-
Q
D
D
I
W
L
A
G
F
S
F
G
--
A
Y
I
S
A
K
---------
V
-
A
Y
D
Q
K
V
A
Q
L
I
S
V
A
P
P
V
FY
E
G
F
A
S
------------------------------
L
-----------------------------------
T
-----------------------------------
Q
------------------
M
-------------------------------------
A
---
S
----
P
-----------------------------
W
L
I
V
Q
G
D
Q
D
E
V
V
P
F
E
Q
V
---
K
A
F
V
N
-
Q
--
I
-----
S
S
-
P
--
V
E
F
-
V
V
M
S
G
A
S
H
F
F
H
G
R
L
----
I
E
-
L
R
E
L
L
V
R
----------
3
PsiBlast_PDB
76.04
27%
-62
- C2 -
-
2I3D
-
?
A:
[25-221]
----------
E
V
I
F
N
G
-
P
A
G
--
R
L
E
G
R
Y
Q
P
S
K
--
E
---
K
S
-
A
P
---
I
A
-
I
I
L
H
P
H
P
Q
F
G
G
T
M
N
N
Q
I
V
Y
Q
L
F
Y
L
F
Q
K
R
G
F
T
T
L
R
F
N
F
R
S
I
G
R
S
Q
G
E
F
D
H
-------
G
--
A
G
E
L
S
D
A
A
S
A
L
D
W
V
Q
S
L
-
H
P
D
S
K
S
C
W
V
A
G
Y
S
F
G
--
A
W
I
G
M
Q
L
L
M
R
-------
R
P
E
I
E
G
F
M
S
I
---
A
P
Q
--
P
N
T
Y
D
------------------------------
F
-----------------------------------
S
-----------------------------------
F
------------------
L
-------------------------------------
A
---
P
----
C
----
P
S
S
G
----------------------
L
I
I
N
G
D
A
D
K
V
A
P
E
K
D
V
N
G
L
V
E
K
L
K
-
T
--
Q
-----
K
G
-
I
--
L
I
T
H
R
T
L
P
G
A
N
H
F
F
N
G
K
V
----
D
E
-
L
----------------
24
HHSearch
75.47
29%
-30
- C2 -
-
2FUK
-
?
A:
[8-218]
------
T
E
S
A
A
L
T
L
D
G
-
P
V
G
P
L
D
V
A
V
D
L
P
E
P
D
V-
A
---
V
Q
-
P
V
---
T
A
-
I
V
C
H
P
L
S
T
E
G
G
S
M
H
N
K
V
V
T
M
A
A
R
A
L
R
E
L
G
I
T
V
V
R
F
N
F
R
S
V
G
T
S
A
G
S
F
D
H
-------
G
--
D
G
E
Q
D
D
L
R
A
V
A
E
W
V
R
A
Q
-
R
P
-
T
D
T
L
W
L
A
G
F
S
F
G
--
A
Y
V
S
L
R
A
A
A
A
-----
L
-----
E
P
Q
V
L
I
S
I
A
P
P
A
--
G
R
W
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
D
----
V
----
Q
P
P
A
Q
--------------------
W
L
V
I
Q
G
D
A
D
E
I
V
D
P
Q
A
V
---
Y
D
W
L
E
-
T
L-
E
Q----
Q
P
-
T
--
L
---
V
R
M
P
D
T
S
H
F
F
H
R
K
L
I
D
L
R
G
A
-
L
Q
H
G
V
R
R
W
L
P
A
------
2
PsiBlast_PDB
75.37
30%
-32
- C2 -
-
2FUK
-
?
A:
[10-205]
--------
S
A
A
L
T
L
D
G
-
P
V
G
--
P
L
D
V
A
V
D
L
P
E
--
P
---
D
V
-
A
V
QP
V
T
A
-
I
V
C
H
P
L
S
T
E
G
G
S
M
H
N
K
V
V
T
M
A
A
R
A
L
R
E
L
G
I
T
V
V
R
F
N
F
R
S
V
G
T
S
A
G
S
F
D
H
-------
G
--
D
G
E
Q
D
D
L
R
A
V
A
E
W
V
R
A
Q
-
R
P
-
T
D
T
L
W
L
A
G
F
S
F
G
--
A
Y
V
S
L
R
A
A
A
A
-----
L
-
E
P
-----
Q
V
L
I
S
I
A
P
P
--
A
---
G
------------------------------
R
-----------------------------------
W
-----------------------------------
D
------------------
F
-------------------------------------
S
---
D
----
V
----
Q
P
P
A
Q
--------------------
W
L
V
I
Q
G
D
A
D
E
I
V
D
P
Q
A
V
---
Y
D
W
L
E
-
T
LE
Q
-----
Q
P
-
T
--
L
---
V
R
M
P
D
T
S
H
F
F
H
R
K
L
----
I
D
-
L
R
---------------
17
HHSearch
73.64
18%
-56
- C2 -
-
2WTM
2
?
B:
[8-247]
---------------
C
-
D
G
I
--
K
L
N
A
Y
L
D
M
P
K
NN
P
---
E
K
-
C
P
---
L
C
-
I
I
I
H
G
F
T
G
H
S
E
-
E
R
--
H
I
V
A
V
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
---------
D
HT-----
L
--
F
K
W
L
T
N
I
L
A
V
V
D
Y
A
K
K
L
-
D
F
-
V
T
D
I
Y
M
A
G
H
S
Q
G
--
G
L
S
V
M
L
A
A
A
M
-----
E
-
R
D
--
I
I
K
A
L
I
P
L
S
P
A
A
--
M
I
P
E
I
A
-----------------------------
R
T
GELLGLKFDPENIPDE------------------
L
D----------------------------------
A
------------------
W
DG
R
K
L
K
G
N
Y
V
R
V
A
Q
T
I---------------------
R
V
E
-
D
----
F
V
D
--
K
Y
T
K
P
--------------------
V
L
I
V
H
G
D
Q
D
E
A
V
P
Y
E
A
S
---
V
A
F
S
K
-
Q
Y-
K
-----
N
C
-
K
--
L
---
V
T
I
P
G
D
T
H
C
Y
D
H
H
L
----
E
L
-
V
T
E
A
V
K
E
F
M
L
E
------
13
HHSearch
73.29
18%
-46
- C2 -
-
3PE6
1
MGLL_HUMAN
A:
[21-292]
------------
H
L
V
N
A
D
G
Q
--
Y
L
F
C
R
Y
W
A
P
T
--
G
---
T
P
-
K
A
---
L
I
-
F
V
S
H
G
A
G
E
H
S
G
-
R
Y
----
E
E
L
A
R
M
L
M
G
L
D
L
L
V
F
A
H
D
H
V
G
H
G
Q
S
E
G
E
R
M
V
VSD----
F
--
H
V
F
V
R
D
V
L
Q
H
V
D
S
M
Q
K
D
-
Y
P
-
G
L
P
V
F
L
L
G
H
S
M
G
--
G
A
I
A
I
L
T
A
A
E
-----
R
-
P
G
--
H
F
A
G
M
V
L
I
S
P
L
V
--
L
A
N
P
E
S
A
----------------------------
T
T
F
K
V
L
A
A
K
V
L
N
S
VLPNLSSGPIDSSVLSRN
K
T
E
V
D
I
Y
N
S
DPLICRAGLK
V
C
F
G
I
Q
----------------
L
L
N
A
V
S
R
------------
V
-------------------------------------
E
---
R
----
A
L
P--
K
L
T
V
P
--------------------
F
L
L
L
Q
G
S
A
D
R
L
C
D
S
K
G
A
---
Y
L
L
M
E
-
L
A-
K
SQ---
D
K
-
T
--
L
---
K
I
Y
E
G
A
Y
H
V
L
H
K
E
L
P
E
V
T
N
S
-
V
F
H
E
I
N
M
W
V
S
Q
------
16
HHSearch
69.52
18%
-49
- C2 -
-
2WTN
6
?
B:
[8-247]
---------------
C
-
D
G
I
--
K
L
N
A
Y
L
D
M
P
K
NN
P
---
E
K
-
C
P
---
L
C
-
I
I
I
H
G
F
T
G
H
S
E
-
E
R
--
H
I
V
A
V
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
H
G
K
S
D
G
K
F
E
D
HT-----
L
--
F
K
W
L
T
N
I
L
A
V
V
D
Y
A
K
K
L
-
D
F
-
V
T
D
I
Y
M
A
G
H
S
Q
G
--
G
L
S
V
M
L
A
A
A
M
-----
E
-
R
D
--
I
I
K
A
L
I
P
L
S
P
A
A
--
M
I
P
E
I
A
-----------------------------
R
T
GELLGLKFDPENIPD
E
------------------
L
D
----------------------------------
A
------------------
W
DG
R
K
L
K
G
N
Y
V
R
V
A
Q
T
I---------------------
R
V
E
-
D
----
F
V
D
--
K
Y
T
K
P
--------------------
V
L
I
V
H
G
D
Q
D
E
A
V
P
Y
E
A
S
---
V
A
F
S
K
-
Q
Y-
K
-----
N
C
-
K
--
L
---
V
T
I
P
G
D
T
H
C
Y
D
H
H
L
----
E
L
-
V
T
E
A
V
K
E
F
M
L
E
------
34
Fugue
67.95
17%
-43
* C2 *
-
2WTM
2
?
A:
[2-251]
---------
G
A
M
Y
I
D
C
-
D
G
I
--
K
L
N
A
Y
L
D
M
P
K
--
N
---
N
P
-
E
K
---
C
P
-
L
C
I
I
I
H
G
F
T
G
H
S
E
E
R
H
I
V
A
V
-
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
H
G
K
S
D
G
K
F
E
D
-------
H
T
L
F
K
W
L
T
N
I
L
A
V
V
D
Y
A
K
K
L
-
D
F
-
V
T
D
I
Y
M
A
G
H
S
Q
G
--
G
L
S
V
M
L
A
A
A
M
-----
E
-
R
D
I
I
K
A
L
I
P
L
S
P
A
A
M
I
--
P
E
I
A
R
------------------------------
T
-----------------------------------
G
-----------------------------------
E
------------------
L
LGLKFDPENIPD
E
L
D
A
WDG
R
K
L
K
G
N
Y
V
R
V
A
Q
T
IR
V
E
D
F
---
V
----
D
----
K
Y
T
K
P
--------------------
V
L
I
V
H
G
D
Q
D
E
A
V
P
Y
E
A
S
---
V
A
F
S
K
Q
Y
--
K
-----
N
C
-
K
--
L
---
V
T
I
P
G
D
T
H
C
Y
D
H
H
L
----
E
L
-
V
T
E
A
V
K
E
F
M
L
E
Q
I
AK--
11
HHSearch
67.40
17%
-53
- C2 -
-
5CML
2
?
B:
[3-250]
--------
I
K
T
V
T
F
E
N
N
R
G
E
--
R
L
A
A
R
L
D
L
P
V
D-
T
---
Q
P
-
V
A
---
Y
A
-
L
F
A
H
C
F
T
C
S
K
N
-
L
--
K
A
V
T
T
I
S
R
A
L
T
T
Q
G
Y
A
V
L
R
F
D
F
T
G
L
G
--------------------
N
F
E
D
L
R
A
A
C
R
F
L
S
A
Q
-
Y
--
E
P
P
A
L
L
I
G
H
S
L
G
--
G
A
A
V
L
A
V
A
G
E
-----
F
-
P
---
E
V
K
A
V
A
T
I
G
A
P
C
--
D
P
A
H
V
R
-----------------------------
H
-----------------------------------
L
L
RPALE
A
V
V
D
LG
G
R
P
F
R
I-----------------
E
------------------
L
ERV----------------------------------
N
---
L
----
E
D
Q
V
R
T
M
R
R
P
--------------------
L
L
L
F
H
S
P
T
D
Q
I
V
G
I
E
N
A
---
A
C
L
F
Q
-
A
A-
R
H----
P
K
-
S
--
F
---
V
S
L
D
Q
A
D
H
L
L
S
N
S
D
D
---
A
A
F
V
G
E
V
L
G
A
W
A
R
R
------
12
HHSearch
66.49
17%
-39
- C2 -
-
5CML
2
?
A:
[3-250]
--------
I
K
T
V
T
F
E
N
N
R
G
E
--
R
L
A
A
R
L
D
L
P
V
D-
T
---
Q
P
-
V
A
---
Y
A
-
L
F
A
H
C
F
T
C
S
K
N
-
L
--
K
A
V
T
T
I
S
R
A
L
T
T
Q
G
Y
A
V
L
R
F
D
F
T
G
L
G
------------------
A
T
N
F
E
D
L
R
A
A
C
R
F
L
S
A
Q
-
Y
--
E
P
P
A
L
L
I
G
H
S
L
G
--
G
A
A
V
L
A
V
A
G
E
-----
F
-
P
---
E
V
K
A
V
A
T
I
G
A
P
C
--
D
P
A
H
V
R
-----------------------------
H
-----------------------------------
L
L
RPALDTTVG
E
A
V
V
D
LG
G
R
P
F
R
I
K
K
Q
F
L
E
------
E
------------------
L
E
R
V
----------------------------------
N
---
L
----
E
D
Q
V
R
T
M
R
R
P
--------------------
L
L
L
F
H
S
P
T
D
Q
I
V
G
I
E
N
A
---
A
C
L
F
Q
-
A
A-
R
H----
P
K
-
S
--
F
---
V
S
L
D
Q
A
D
H
L
L
S
N
S
D
D
---
A
A
F
V
G
E
V
L
G
A
W
A
R
R
------
15
HHSearch
64.32
22%
-10
- C2 -
-
2I3D
-
?
B:
[23-231]
--------
M
P
E
V
I
F
N
G
P
A
G
---
R
L
E
G
R
Y
Q
P
S
K
--
E
---
K
S
-
A
P
---
I
A
-
I
I
L
H
P
H
P
Q
F
G
G
T
M
N
N
Q
I
V
Y
Q
L
F
Y
L
F
Q
K
R
G
F
T
T
L
R
F
N
F
R
S
I
G
R
S
Q
G
E
F
D
H
-------
G
--
A
G
E
L
S
D
A
A
S
A
L
D
W
V
Q
S
L
H
P
D
-
S
K
S
C
W
V
A
G
Y
S
F
G
--
A
W
I
G
M
Q
L
L
M
R
-----
R
-
P
---
E
I
E
G
F
M
S
I
A
P
Q
P
--
N
T
Y
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
F
----
L
A---
P
C
P
S
S
--------------------
G
L
I
I
N
G
D
A
D
K
V
A
P
E
K
D
V
---
N
G
L
V
E
-
K
L
-
K
T
QKG
I
L
I
-
T
--
H
---
R
T
L
P
G
A
N
H
F
F
N
G
K
V
----
D
E
-
L
M
G
E
C
E
D
Y
L
D
R
------
9
HHSearch
63.32
17%
-28
- C2 -
-
3PFB
1
?
A:
[18-265]
----
Y
F
Q
G
M
A
T
I
T
L
E
R
-
D
G
L
--
Q
L
V
G
T
R
E
E
P
F
--
G
---
E
I
-
Y
D
---
M
A
-
I
I
F
H
G
F
T
A
N
R
N
---
T
S
L
L
R
E
I
A
N
S
L
R
D
E
N
I
A
S
V
R
F
D
F
N
G
H
G
D
S
D
G
K
F
E
N
MT-----
V
--
L
N
E
I
E
D
A
N
A
I
L
N
Y
V
K
T
D
-
P
H
-
V
R
N
I
Y
L
V
G
H
A
Q
G
--
G
V
V
A
S
M
L
A
G
L
-----
Y
-
P
D
--
L
I
K
K
V
V
L
L
A
P
A
A
--
T
L
K
G
D
A
L
----------------------------
E
GNTQGVTYNPDHIPD
R
-------------------
L
P
F
KD
L
T
L
G
---------------------------
G
F
Y
L
R
I
A
Q
Q
----------
L
-------------------------------------
P
---
I
Y
E
V
S
A
----
Q
F
T
K
P
--------------------
V
C
L
I
H
G
T
D
D
T
V
V
S
P
N
A
S
---
K
K
Y
D
Q
-
I
Y
-
Q
-----
N
S
-
T
--
L
---
H
L
I
E
G
A
D
H
C
F
S
D
S
Y
Q
---
K
N
-
A
V
N
L
T
T
D
F
L
Q
-------
10
HHSearch
62.65
18%
-21
- C2 -
-
3QM1
1
?
A:
[19-265]
-----
F
Q
G
M
A
T
I
T
L
E
R
-
D
G
L
--
Q
L
V
G
T
R
E
E
P
F
--
G
---
E
I
-
Y
D
---
M
A
-
I
I
F
H
G
F
T
A
N
R
N
---
T
S
L
L
R
E
I
A
N
S
L
R
D
E
N
I
A
S
V
R
F
D
F
N
G
H
G
D
S
D
G
K
F
E
N
MT-----
V
--
L
N
E
I
E
D
A
N
A
I
L
N
Y
V
K
T
D
-
P
H
-
V
R
N
I
Y
L
V
G
H
A
Q
G
--
G
V
V
A
S
M
L
A
G
L
-----
Y
-
P
D
--
L
I
K
K
V
V
L
L
A
P
A
A
--
T
L
K
G
D
A
L
----------------------------
E
GNTQGVTYNPDHIPDR-------------------
L
PFKD
L
T
L
G
G
F
Y
L
-----------------------
R
------------------
I
A
Q
Q
L---------------------------------
P
I
Y
-
E
V
S
--
A
----
Q
F
T
K
P
--------------------
V
C
L
I
H
G
T
D
D
T
V
V
S
P
N
A
S
---
K
K
Y
D
Q
-
I
Y-
Q
-----
N
S
-
T
--
L
---
H
L
I
E
G
A
D
H
C
F
S
D
S
Y
Q
---
K
N
-
A
V
N
L
T
T
D
F
L
Q
-------
5
PsiBlast_PDB
60.72
19%
-33
- C2 -
-
2WTN
6
?
A:
[12-246]
----------------------
K
L
N
A
Y
L
D
M
P
K
--
N
---
N
P
-
E
K
---
C
P
-
L
C
I
I
I
H
G
F
T
G
H
S
E
E
R
H
I
V
A
V
-
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
H
G
K
S
D
G
K
F
E
D
-------
H
T
L
F
K
W
L
T
N
I
L
A
V
V
D
Y
A
K
K
L
-
D
F
-
V
T
D
I
Y
M
A
G
H
S
Q
G
G
L
S
V
M
L
A
A
A
M
E
R
DIIK
A
L
-
I
P
-
L
S
P
A
A
M
I
P
E
I
A
R
T
--
G
E
L
L
G
------------------------------
L
-----------------------------------
K
-----------------------------------
F
DPENIPD
E
L
D
A
-------
W
-------------------------------------
D
---
G
----
R
----
K
L
K
G
N
Y
V
R
V
A
Q
T
IR
V
E
D
F
V
D
K
Y
T
K
P
V
L
I
V
H
G
D
Q
D
E
A
V
P
Y
E
A
S
---
V
A
F
S
K
-
Q
--
Y
-----
K
N
C
K
--
L
---
V
T
I
P
G
D
T
H
C
Y
D
H
H
L
----
E
L
-
V
T
E
A
V
K
E
F
M
L
-------
4
PsiBlast_PDB
59.93
19%
-29
- C2 -
-
2WTM
1
?
A:
[12-246]
----------------------
K
L
N
A
Y
L
D
M
P
K
--
N
---
N
P
-
E
K
---
C
P
-
L
C
I
I
I
H
G
F
T
G
H
S
E
E
R
H
I
V
A
V
-
Q
E
T
L
N
E
I
G
V
A
T
L
R
A
D
M
Y
G
H
G
K
S
D
G
K
F
E
D
-------
H
T
L
F
K
W
L
T
N
I
L
A
V
V
D
Y
A
K
K
L
-
D
F
-
V
T
D
I
Y
M
A
G
H
S
Q
G
G
L
S
V
M
L
A
A
A
M
E
R
DIIK
A
L
-
I
P
-
L
S
P
A
A
M
I
P
E
I
A
R
T
--
G
E
L
L
G
------------------------------
L
-----------------------------------
K
-----------------------------------
F
DPENIPD
E
L
D
A
-------
W
-------------------------------------
D
---
G
----
R
----
K
L
K
G
N
Y
V
R
V
A
Q
T
IR
V
E
D
F
V
D
K
Y
T
K
P
V
L
I
V
H
G
D
Q
D
E
A
V
P
Y
E
A
S
---
V
A
F
S
K
-
Q
--
Y
-----
K
N
C
K
--
L
---
V
T
I
P
G
D
T
H
C
Y
D
H
H
L
----
E
L
-
V
T
E
A
V
K
E
F
M
L
-------
27
HHSearch
59.64
17%
-40
- C2 -
-
3FOB
-
?
C:
[5-281]
---------
A
K
I
T
V
G
T
E
N
Q
A
--
P
I
E
I
Y
Y
E
D
H
-------
G
T
-
G
K
---
P
V
-
V
L
I
H
G
W
P
L
S
G
R
-
S
W
E
----
Y
Q
V
P
A
L
V
E
A
G
Y
R
V
I
T
Y
D
R
R
G
F
G
K
S
S
Q
P
W
E
G
YE-----
Y
--
D
T
F
T
S
D
L
H
Q
L
L
E
Q
L
-----
E
-
L
Q
N
V
T
L
V
G
F
S
M
G
--
G
G
E
V
A
R
Y
I
S
T
-----
Y
G
T
D
--
R
I
E
K
V
V
F
A
G
A
V
P
--
P
Y
L
Y
K
SEDHPEGALDDATIETFKSGVINDRLAFLD
E
-----------------------------------
F
TKGFFAAGDRTDLVSESFRLY--------------
N
WDIAAGASPKGTLDCITA
F
SKT----------------------------------
D
FR-
K
DL--
E
----
K
F
N
I
P
--------------------
T
L
I
I
H
G
D
S
D
A
T
V
P
F
E
Y
S
---
G
K
L
T
H
-
E
AI
P
-----
N
S
-
K
--
V
---
A
L
I
K
G
G
P
H
G
L
N
A
T
H
A---
K
E
-
F
N
E
A
L
L
L
F
L
K
D
------
26
HHSearch
55.93
17%
-47
- C2 -
-
1C4X
-
?
A:
[12-283]
-----------------
P
S
G
--
T
L
A
S
H
A
L
V
A
G
--
D
---
P
Q
-
S
P
---
A
V
-
V
L
L
H
G
A
G
P
G
A
H
A
A
--
S
N
W
R
P
I
I
P
D
L
A
-
E
N
F
F
V
V
A
P
D
L
I
G
F
G
Q
S
E
Y
P
E
T
Y
PGH
I
M
S
W
V
--
G
M
R
V
E
Q
I
L
G
L
M
N
H
F
-----
G
-
I
E
K
S
H
I
V
G
N
S
M
G
--
G
A
V
T
L
Q
L
V
V
E
-----
A
-
P
E
--
R
F
D
K
V
A
L
M
G
S
V
G
--
A
P
M
N
A
RP
P
E
L
A
R
L
L
A
FYADPR
L
T
P
Y
R
---------
E
L
I
H
S
-------------------------------
F
V
YDPENFPG
M
E
E
I
V
K
S
R
F
E
V
A
N
D
P
E
V
R
R
I
Q
E
V
M
F
E
S
------------------
M
K
AGMESL------------------------------
V
IP
P
A
----
T
L
G
--
R
L
P
H
D
--------------------
V
L
V
F
H
G
R
Q
D
R
I
V
P
L
D
T
S
---
L
Y
L
T
K
-
H
L-
K
-----
H
A
-
E
--
L
---
V
V
L
D
R
C
G
H
W
A
Q
L
E
R
W---
D
A
-
M
G
P
M
L
M
E
H
F
R
A
------