@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0525: (2016-03-16 )
MATQKNLVDLATKAYIYGFPFIFNTQQIERYVTVGIGGTKQVPFNNFTHASRLAEPSDKFVSVNNDTIYSNAPIDVSAGPVVLSVPDTSGRYYVLQFVDAWSNNFAYVGKRATGTSAGKFLLTPPNWNGDVPADMIEIKFPTNIGIIIGRLACDGEADLPTVRELQEQLKITPLNEGKEVDGFPEYDRSLGKELAFFEQLRVYMAQFPPAERDLVKQESFAPIGLMEKGVSPYSNPSEELKNALIEGAKAGLANIKKATTNFKSENGWGLTQHLFDYNADFFEIGTKKSLDWVIEDREEAYIIRAVSAITALWGNHGYEAVYLMTWTDTDGNALNGKNKYTLELNPIPPVDSFWSITMYDLPEYFLCENPINRYSIGDRTPGIQYNDDGGITIVVSKDEPTDPKERANWLPAPDAEFRPMFRLYNPQQPLVDGSYHFPGFEKK
Atome Classification :
(20 SA)
-------------------------.......-..10-........20-----.........30....-....40........50.....--------...60...--.....70.-.-....-------..-.--80-----------------......-----.-.-.90-......-.-.100------.-------....---..--------------110...-....120-------------------..-..--....130.-....---.-.---.-.140...---...----.-----.150...--.....160....-...-170-........-----.180..-..-.----..--------.-190-.-.-----.-.------....-200.......--.-210....----.--...220...--....230.....--...240--........250...------.....260.------....---..--.-270.------......280.-.-..--..--.290-....-------..-----.---..300....------...---.310..-..----.------..320..---......330--........-340---..-.-----...----...350---...-.....--.360.-----.--------..-..---.370.....-..---.380........390..---.....400.-----....---..410.------------...-....420...-.----....430....--...440.----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MAT
Q
K
N
L
-
V
D
L
A
-
T
K
A
Y
I
YGFP------
F
I
F
N
T
Q
Q
I
E
R
Y
V
T
VG-IGGTKQVPFNNFT
H
A
S
RLAEP--------SD
K
F
V
S
VN--N
D
T
IYS-N-A-PIDV-------SA-G--
P
------------------
V
V
L
SVP-----D-T-SG
R
-
Y
Y
V
L
Q
F
-
V
-
D
A
WS------N-------N
F
A
Y
---VG--------------KRATGT-SA
G
K
F
L
--------------------LT-PP--NWNGD--V-PA
D
M
---
I
-
E
---
I
-KFP-TNI---
G
I
I
----
I
-----
G
R
L
-ACD--GEADL
P
T
V
R
E
L
Q
-
E
QL-K---ITPLNEGK-----EV-DGF-
P
E
-
Y
----
D
R
--------
S
-
L
G
--
K
-
E
-----
L
-
A
------
F
F
E
Q
-
L
-
R
V
Y
M
A
QFP--P-
A
E
-
R
D
L
V
----
K
--QESFAPI
G
L
--
M
E
KGV-SPYS
N
P
--
S
E
E
L
K
---
N
A
L
I
E
G
A
K
A
G
-
L
A
N
------
I
K
K
A
TT-NF------KSEN---GW--
G
-
L
T
Q
H
------
L
F
DYNAD
F
F
E-I-GT--KK--S
L
---
D
W
V
I-------ED-----R---E
E
A
-
Y
I
I
R
A
------
V
S
A
---
I
T
A
L
W
G-NH----G------Y
E
A
V
-
Y
L
---
M
T
W
TDTDG---NALNGK
N
K
-
Y
-----
T
L
-E-----LNP----IPPV-----D
S
F
-
W
S
I
T
M
--YDL
P
E
-----
Y
--------
F
L-CE---NPI-NRYSI-GD---RT-PG
I
Q
YNDDG
G
I
T
I
V
---
V
SKDEPT
D
P
-----
K
E
RA---NWLP-A------------PDA-E
F
R
P
M
F
-
R
LY-N----PQQPLVDGSYH--FPGFEKK----------------------------------------
3
PsiBlast_PDB
89.00
24%
-74
- C7 -
3VB9
2
?
A:
[119-474]
-----------------------------------------------------------------------------------------------------------------------------------
T
-
G
--
P
------------------
L
I
I
N
L
P
-----
E
-
A
-
K
M
A
-
G
M
M
L
D
V
-
H
-
Q
R
V
L
------
S
-------
D
L
S
L
---
L
G
----------------
P
D
K
G
-
K
G
G
K
Y
L
--------------------
I
V
-
P
P
GE
K
Y
K
D
L
--
N
-
P
K
G
Y
---
Y
-
V
---
I
-
R
P
K
-
T
N
V
----
V
Y
----
G
-----
G
I
R
-
I
L
E
--
P
D
V
D
R
-
V
V
K
Q
V
V
-
P
N
I
-
T
---
T
Q
P
Y
A
D
G
K
LGRKI
P
V
-
A
Q
V
-
P
E
-
I
----
D
W
--------
T
H
I
P
--
K
-
D
G----
L
-
E
------
Y
W
K
T
-
I
-
H
Q
I
I
Q
E
N
P
--
V
-
E
E
-
R
D
R
F
----
V
--
M
A
Q
L
K
F
L
G
I
---
E
K
G
--
K
P
F
-
N
P
--
T
E
E
Q
K
---
K
I
L
L
E
A
S
K
V
G
-
R
A
M
A
Q
S
N
D
Y
T
K
R
F
T
Q
-
P
Y
------
W
K
G
T
---
N
W
KD
A
-
I
S
V
S
------
L
D
Q
R
S
E
N
Y
D
E
-
L
-
D
E
--
R
A
--
A
-----
W
F
Y
-------
E
---------------------------
A
---
I
T
V
S
R
G
-
M
K
STIP
G
------
F
G
Q
R
-
Y
L
---
V
T
Y
Q
D
S
D
G
---
N
W
L
S
G
E
H
T
-
Y
-----
K
L
-
H
-----
V
P
A
----
N
V
P
A
-----
S
N
F
-
W
S
T
T
V
--
Y
D
E
N
N
-----
R
--------
L
M
-
I
I
---
N
D
A
-
G
S
P
D
I
-
S
S
---
R
K
--
N
L
K
V
N
S
D
G
S
I
D
V
Y
---
Y
G
P
-
K
P
V
K
G
-----
Y
E
N
----
N
W
V
Q
-
T
N
-----------
P
G
E
-
G
W
F
T
Y
F
-
R
F
Y
-
G
----
P
T
E
K
M
F
D
K
S
W
--------------------------------------------------
12
HHSearch
79.40
27%
18
- C7 -
3U07
-
?
A:
[25-433]
------------------------------
T
N
-
V
D
L
A
-
E
D
A
Y
I
Y
G
Y
S
------
I
D
E
A
Y
K
F
F
Y
H
T
-
A
-----
V
E
N
N
Y
P
L
N
E
F
Q
--------------------
P
T
I
N
--
N
D
T
L
H
L
-
M
-
G
-
W
L
D
V
-------
A
A
-
E
--
P
------------------
V
I
V
S
V
P
-----
D
-
M
D
E
G
R
-
Y
W
I
L
H
T
-
M
-
D
M
G
H
------
Y
-------
T
N
A
A
---
F
S
--------------
S
R
T
R
G
T
-
K
G
G
Q
F
M
--------------------
F
A
-
A
Q
--
D
W
Q
G
E
--
V
-
P
A
S
V
---
D
E
V
---
V
-
R
V
D
-
S
N
L
---
V
K
L
----
M
-----
G
R
I
-
M
A
V
--
N
D
E
D
A
K
V
A
L
N
Y
M
-
D
Q
W
-
N
---
I
R
T
L
S
E
Y
L
-----
G
K
-
N
G
P
K
P
V
Q
R
----
T
Y
--------
P
-
D
P
--
K
-
K
-----
S
-
T
------
W
L
E
R
-
V
-
N
F
V
L
C
D
G
S
M
G
N
-
A
D
-
K
Q
W
L
----
D
--
K
--
Y
Q
S
I
G
V
--
E
-
P
C
K
T
D
F
--
T
P
--
E
--
Q
L
---
K
L
A
K
V
G
E
K
K
G
-
M
E
H
------
L
V
E
L
A
P
---------
K
M
T
D
---
A
R
--
T
-
L
L
G
T
------
R
D
T
L
G
---------
D
--------------------------------------
A
P
R
D
------
I
F
A
E
G
T
Y
L
G
Q
W
G
-
L
P
----
P
------
I
E
A
S
-
Y
R
---
K
S
D
F
D
S
I
G
---
Q
K
L
D
G
S
K
H
D
Y
-----
V
M
-
R
-----
F
K
A
-----
P
N
V
-----
S
E
F
-
W
S
V
T
I
--
Y
G
N
D
N
-----
R
--------
L
M
-
A
K
---
N
D
L
-
N
R
H
S
R
-
G
D
---
R
T
---
M
K
A
D
K
D
G
Y
Y
T
I
Y
---
M
S
A
N
E
K
G
R
------
A
D
D
P
---
N
F
L
P
-
V
------------
P
E
K
-
P
F
Y
A
I
M
-
R
F
Y
-
G
----
A
D
D
A
I
Q
S
G
E
Y
Q
--
M
P
E
I
K
V
-----------------------------------------
1
PsiBlast_PDB
78.01
26%
11
- C7 -
3U07
-
?
A:
[27-429]
---------------------------------
V
D
L
A
-
E
D
A
Y
I
Y
G
Y
S
I
D
E
A
Y
K
F
F
Y
H
T
A
V
E
N
N
Y
------------
P
L
N
E
F
Q
--------------------
P
T
I
N
--
N
D
T
L
H
L
-
M
-
G
-
W
L
D
V
-------
A
A
-
E
--
P
------------------
V
I
V
S
V
P
-----
D
-
M
D
E
G
R
-
Y
W
I
L
H
T
-
M
-
D
M
G
H
------
Y
-------
T
N
A
A
---
F
S
--------------
S
R
T
R
G
T
-
K
G
G
Q
F
M
--------------------
F
A
-
A
Q
--
D
W
Q
G
E
--
V
-
P
A
S
V
---
D
-
E
---
V
V
R
V
D
-
S
N
L
---
V
K
L
----
M
-----
G
R
I
-
M
A
V
--
N
D
E
D
A
K
V
A
L
N
Y
M
-
D
Q
W
-
N
---
I
R
T
L
S
E
Y
L
-----
G
K
-
N
G
P
-
K
P
-
V
----
Q
R
--------
T
-
Y
P
DP
K
-
K
-----
S
-
T
------
W
L
E
R
-
V
-
N
F
V
L
C
D
G
S
--
M
-
G
N
-
A
D
K
Q
----
W
--
L
D
K
Y
Q
S
I
G
V
EP
C
K
T
D
F
-
T
P
-------
E
Q
L
K
---
L
A
K
V
G
E
K
K
G
M
-
E
H
L
------
V
E
L
A
P
K
-
M
T
------
D
A
R
T
---
L
L
--
G
-
T
R
D
T
------
L
G
D
A
P
R
D
I
F
A
-
E
-
G
T
------------------------------------------------------
Y
L
G
Q
W
G
-
L
P
----
P
------
I
E
A
S
-
Y
R
---
K
S
D
F
D
S
I
G
---
Q
K
L
D
G
S
K
H
-
D
-----
Y
V
-
M
-----
R
F
K
----
A
P
N
V
-----
S
E
F
-
W
S
V
T
I
--
Y
G
N
D
N
-----
R
--------
L
M
-
A
K
---
N
D
L
-
N
R
H
S
R
-
G
D
---
R
T
---
M
K
A
D
K
D
G
Y
Y
T
I
Y
---
M
S
A
N
E
---------
K
G
R
A
DDP
N
F
L
P
-
V
------------
P
E
K
-
P
F
Y
A
I
M
-
R
F
Y
-
G
----
A
D
D
A
I
Q
S
G
E
Y
Q
--
M
P
---------------------------------------------
22
Fugue
72.15
26%
12
* C7 *
3U07
-
?
A:
[25-435]
------------------------------
T
N
-
V
D
L
A
-
E
D
A
Y
I
Y
G
Y
S
------
I
D
E
A
Y
K
F
F
Y
H
T
A
V
E
N
-------------------
N
Y
P
--------
L
N
E
F
Q
P
T
I
--
N
N
D
T
L
H
-
L
M
G
-
W
L
D
V
-------
A
A
-
E
--
P
------------------
V
I
V
S
V
P
-----
D
M
D
-
E
G
R
-
Y
W
I
L
H
T
M
D
M
G
H
Y
T
------
N
---------
A
A
---
F
S
--------------
S
R
T
R
G
T
-
K
-
G
G
Q
F
M
-------------------
F
A
-
A
Q
--
D
W
Q
G
E
--
V
-
P
A
S
V
---
D
-
E
---
V
-
V
R
V
-
D
S
N
---
L
V
K
----
L
M
----
G
R
I
M
A
V
N
--
D
E
D
A
K
--
V
A
L
N
Y
M
D
Q
W
-
N
---
I
R
T
L
S
E
Y
L
-----
G
K
-
N
G
P
-
K
P
-
V
----
Q
R
--------
T
-
Y
P
--
D
P
K
-----
K
-
S
------
T
W
L
E
-
R
-
V
N
F
V
L
C
D
G
--
S
M
G
N
-
A
D
K
Q
----
W
--
L
D
K
Y
Q
S
I
G
V
--
E
P
C
-----
K
T
D
F
--
T
P
E
Q
L
---
K
L
A
K
V
G
E
K
K
G
M
E
H
L
------
V
E
L
A
P
K
M
T
D
------
A
R
T
L
---
L
---
G
-
T
R
D
T
------
L
G
D
A
P
-----------------------------------------------
R
D
I
F
A
------
E
G
T
---
Y
L
G
Q
W
G
-
L
P
----
P
------
I
E
A
S
-
Y
R
---
K
S
D
F
D
S
I
G
---
Q
K
L
D
G
S
K
H
-
D
-----
Y
V
M
R
-----
F
K
A
-----
P
N
V
-----
S
E
F
-
W
S
V
T
I
--
Y
G
-
N
D
-----
N
--------
R
L
M
A
K
---
N
D
L
-
N
R
H
S
R
-
G
D
---
R
T
M
K
---
A
D
K
D
G
Y
Y
T
I
Y
M
--
S
A
N
E
K
G
R
A
D
-----
D
P
-----
N
F
L
P
-
V
------------
P
E
K
-
P
F
Y
-
A
I
M
R
F
Y
-
G
----
A
D
D
A
I
Q
S
G
E
Y
Q
M-
P
E
I
K
V
V
K
----------------------------------------
11
HHSearch
67.83
22%
21
- C7 -
2P3Y
-
?
A:
[49-481]
---------------------------
L
N
E
M
D
-
F
Q
R
A
-
T
Q
A
Y
L
W
G
I
P
------
A
S
S
I
M
E
W
L
N
V
S
R
N
D
F
K
F
E
E
G
Q
M
G
F
F
N
T
L
K
Q
------
K
--------
Q
-
G
I
I
T
A
N
--
F
T
T
P
Y
V
-
I
-
G
-
T
W
N
L
-------
E
K
T
G
--
P
------------------
L
I
I
N
L
P
-----
E
-
A
-
K
M
----
A
G
M
M
-
L
-
D
V
H
Q
------
R
-------
V
L
S
D
LSL
L
G
--------------
P
D
K
-
G
--
K
G
G
K
Y
L
--------------------
I
V
-
P
P
--
G
E
K
Y
K
D
L
N
-
P
K
G
Y
---
Y
-
V
---
I
-
R
P
K
-
T
N
V
---
V
Y
G
----
G
-----
I
R
I
-
L
E
P
--
D
V
-
D
-
R
V
V
K
Q
V
V
-
P
N
I
-
T
---
T
Q
P
Y
A
D
G
K
-----
L
G
-
R
K
I
--
P
-
V
----
A
Q
VPEIDWTH
I
-
P
K
--
D
-
G
-----
L
-
E
------
Y
W
K
T
-
I
-
H
Q
I
I
Q
E
N
P
VE
E
-
R
D
-
R
F
V
M
----
A
--
Q
--
L
K
F
L
G
I
--
E
-
K
G
K
-
P
F
--
N
P
--
T
E
E
Q
K
---
K
I
L
L
E
A
S
K
V
G
-
R
A
M
------
A
Q
S
N
D
Y
-
T
K
RFTQPY
W
K
G
T
---
N
W
--
K
-
D
A
I
S
VS----
L
D
Q
R
---------------------------------
S
E
-----
N
---
Y
D
E
-
L
D
E
R
A
A
W
F
Y
EA
I
T
V
---
S
R
G
M
K
S
T
I
P
----
G
------
F
G
Q
R
-
Y
L
---
V
T
Y
Q
D
S
D
G
---
N
W
L
S
G
E
H
T
-
Y
-----
K
L
-
H
-----
V
P
A
----
N
V
P
A
-----
S
N
F
-
W
S
T
T
V
--
Y
D
E
N
N
-----
R
--------
L
M
-
I
I
---
N
D
A
-
G
S
P
D
I
-
S
S
---
R
K
-
N
-
L
K
V
N
S
D
G
S
I
D
V
Y
---
Y
G
P
K
P
V
K
-------
G
Y
E
N
---
N
W
V
Q
-
T
------------
N
P
G
E
G
W
F
T
Y
F
-
R
F
Y
-
G
----
P
T
E
K
M
F
D
K
S
W
T
--
M
G
D
I
E
L
-----------------------------------------
25
Fugue
64.86
16%
-31
* C4 *
4QT9
2
?
A:
[19-432]
--------------------------
L
S
D
D
A
L
M
D
T
V
Q
-
R
R
T
F
L
Y
F
W
E
--------------------
G
-
A
E
P
N
S
G
L
A
P
E
R
Y
H
V
D
G
V
Y
P
Q
N
--------
D
A
N
V
V
T
S
G
--
G
S
G
F
G
I
M
A
-
I
-
L
A
G
I
-------
D
R
-
G
--
Y
------------------
V
--
T
R
E
-----
E
-
G
-
L
A
R
M
E
R
I
V
S
F
-
L
-
E
K
A
D
------
R
-------
F
H
G
A
---
Y
P
--------------
H
W
W
Y
G
D
-
T
-
G
K
-----------------------
V
-
K
P
--
F
G
Q
K
D
--
N
-
G
G
D
L
---
V
-
E
---
T
-
A
F
L
M
Q
G
L
---
L
A
V
----
H
-----
Q
Y
Y
-
A
N
G
--
N
D
K
E
K
A
I
A
Q
R
I
D
-
R
L
W
-
R
E
VD
W
D
W
Y
R
K
G
G
-----
Q
N
-
V
L
Y
-
W
H
-
W
----
S
P
--------
T
-
Y
G
--
W
-
E
MD
F
P
I
H
-
G
------
Y
N
E
C
M
I
M
Y
I
L
A
A
A
S
P
--
T
-
H
G
V
P
A
A
V
----
Y
--
H
D
G
W
A
Q
N
G
A
--
I
---
V
-
S
P
H
K
V
E
--
G
I
E
L
H
---
L
R
Y
-
Q
G
T
E
A
G
-----------------------------------------
P
------
L
F
W
A
Q
Y
S
F
L
G
-
L
-
D
P
--
V
G
--
L
K
---
D
E
Y
C
-------
P
S
-----
Y
---
F
H
E
M
R
N
L
T
L
------
V
N
R
---
A
Y
C
I
R
N
-
P
K
----
H
------
Y
K
G
F
-
G
P
---
D
C
W
G
L
T
A
S
---
Y
S
V
D
G
Y
A
A
-
H
-----
S
P
-
N
-----
E
Q
D
DKGV
I
S
P
T
-----
A
A
L
-
S
S
I
V
Y
----
T
P
E
-----
Y
--------
S
L
-
Q
------
V
M
R
H
L
Y
N
M
G
D
---
K
V
-
F
G
-----
P
F
G
F
Y
D
A
---
F
S
E
T
D
N
W
Y
P
QRYL
A
I
D
Q
G
---
P
I
A
V
M
I
------------
E
N
Y
-
R
T
G
L
L
W
-
K
L
F
M
S
------
H
P
D
V
Q
A
G
L
T
--
K
L
G
F
N
T
N
----------------------------------------
2
PsiBlast_PDB
63.64
24%
21
- C7 -
2P3Y
-
?
A:
[119-474]
-----------------------------------------------------------------------------------------------------------------------------------
T
-
G
--
P
------------------
L
I
I
N
L
P
-----
E
-
A
-
K
M
A
-
G
M
M
L
D
V
-
H
-
Q
R
V
L
------
S
-------
D
L
S
L
---
L
G
----------------
P
D
K
G
-
K
G
G
K
Y
L
--------------------
I
V
-
P
P
GE
K
Y
K
D
L
--
N
-
P
K
G
Y
---
Y
-
V
---
I
-
R
P
K
-
T
N
V
----
V
Y
----
G
-----
G
I
R
-
I
L
E
--
P
D
V
D
R
-
V
V
K
Q
V
V
-
P
N
I
-
T
---
T
Q
P
Y
A
D
G
K
LGRKI
P
V
-
A
Q
V
-
P
E
-
I
----
D
W
--------
T
H
I
P
--
K
-
D
G----
L
-
E
------
Y
W
K
T
-
I
-
H
Q
I
I
Q
E
N
P
--
V
-
E
E
-
R
D
R
F
----
V
--
M
A
Q
L
K
F
L
G
I
---
E
K
G
--
K
P
F
-
N
P
--
T
E
E
Q
K
---
K
I
L
L
E
A
S
K
V
G
-
R
A
M
A
Q
S
N
D
Y
T
K
R
F
T
Q
-
P
Y
------
W
K
G
T
---
N
W
KD
A
-
I
S
V
S
------
L
D
Q
R
S
E
N
Y
D
E
-
L
-
D
E
--
R
A
--
A
-----
W
F
Y
-------
E
---------------------------
A
---
I
T
V
S
R
G
-
M
K
STIP
G
------
F
G
Q
R
-
Y
L
---
V
T
Y
Q
D
S
D
G
---
N
W
L
S
G
E
H
T
-
Y
-----
K
L
-
H
-----
V
P
A
----
N
V
P
A
-----
S
N
F
-
W
S
T
T
V
--
Y
D
E
N
N
-----
R
--------
L
M
-
I
I
---
N
D
A
-
G
S
P
D
I
-
S
S
---
R
K
--
N
L
K
V
N
S
D
G
S
I
D
V
Y
---
Y
G
P
-
K
P
V
K
G
-----
Y
E
N
----
N
W
V
Q
-
T
N
-----------
P
G
E
-
G
W
F
T
Y
F
-
R
F
Y
-
G
----
P
T
E
K
M
F
D
K
S
W
--------------------------------------------------
26
Fugue
58.15
19%
-3
* C5 *
4JE5
5
ARO8_YEAST
A:
[5-502]
T
L
P
E
S
K
D
FSYLFS
D
E
T
N
A
RKPSPLK
L
F
Q
D
P
N
I
-
I
F
L
G
-
G
G
L
P
L
K
D
Y
F
------
P
W
D
N
L
S
V
D
S
P
K
P
P
F
P
-
Q
G
I
G
A
P
I
D
E
Q
N
C
I
K
Y
T
V
N
K
D
Y
--------
A
D
K
S
A
N
P
S
--
N
D
I
P
L
S
-
R
-
A
L
Q
Y
G
F
-------
S
A
-
G
Q
P
E
------------------
L
L
N
F
I
R
-----
D
-
H
-
T
K
I
-
I
H
D
L
K
Y
-
K
-
D
-
W
D
V
L
A
T
AG
N
-------
T
N
A
W
---
E
S
--------------
T
L
R
V
F
C
-
N
R
G
D
V
I
--------------------
L
V
-
E
A
--
H
S
F
S
S
--
S
-
L
A
S
A
---
E
-
A
Q
G
V
I
-
T
F
P
-
V
P
I
D
AD
G
I
I
----
P
-----
E
K
L
-
A
K
V
--
M
E
N
W
T
P
G
A
P
K
P
K
--
L
L
-
Y
---
T
I
P
T
G
Q
N
P
-----
T
G
-
T
S
I
-
A
D
-
H
----
R
K
--------
E
-
A
I
--
Y
-
K
-----
I
-
A
Q
K
Y
D
F
L
I
V
E
D
-
E
-
P
Y
Y
F
L
Q
M
N
--
P
-
Y
I
-
K
D
L
K
----
E
--
R
E
K
A
Q
S
-----------
S
P
K
Q
D
H
--
D
E
F
L
K
S
L
A
N
T
F
L
S
L
D
T
E
G
-
R
V
I
------
R
M
D
S
F
S
-
K
V
------
L
A
P
G
TR
L
G
W
I
-
T
-
G
S
S
K
------
I
L
K
P
Y
L
S
L
H
E
-
M
-
T
I
--
Q
A
--
P
---------------------------
A
G
-
F
T
Q
V
L
------
V
N
A
---
T
L
S
R
W
G
-
Q
K
----
G
------
Y
L
D
W
-
L
L
G
L
R
H
E
Y
T
L
K
R
D
---
C
A
I
D
A
L
Y
K
-
Y
LPQSD
A
F
-
V
-----
I
N
P
-----
P
I
A
-----
G
M
F
-
F
T
V
N
I
DA
S
V
H
P
E
-----
F
KTKYNSD
P
Y
Q
-
L
E
---
Q
S
L
-
Y
H
K
V
V
-
E
R
G
V
L
V
V
-
P
G
S
W
F
K
S
E
G
----------
E
T
E
P
P
Q
P
-----
A
E
S
K
---
E
V
S
N
-
P
------------
N
I
I
-
F
F
R
G
T
Y
-
A
A
V
-
S
----
P
E
K
L
T
E
G
L
K
R
L
--
G
D
T
L
Y
E
E
F
GIS------------------------------------
27
Fugue
57.39
14%
-22
- C4 -
4UM2
1
EST1A_HUMAN
A:
[1-582]
-------------------------
S
M
E
L
H
R
L
-
L
R
V
A
-
D
N
Q
E
L
Q
L
S
N
------
L
L
S
R
----
D
R
I
S
P
E
G
-
L
E
K
M
A
Q
L
R
A
E
L
L
Q
L
Y
E
R
C
I
L
L
--------
D
I
E
F
S
D
N
Q
N
V
D
Q
I
L
W
K
-
N
-
A
-
F
Y
Q
V
-------
I
E
-
K
--
F
------------------
R
Q
L
V
K
D
PNVEN
P
-
E
-
Q
I
R
-
N
R
L
L
E
L
-
L
-
D
E
G
S
------
D
-------
F
F
D
S
---
L
L
--------------
Q
K
L
Q
V
T
-
Y
K
F
K
L
E
--------------------
D
Y
-
M
D
--
G
L
A
I
R
--
L
-
R
K
T
V
---
K
-
Y
---
A
-
L
I
S
-
A
Q
R
---
C
M
I
C
Q
G
D
I
-----
A
R
Y
-
R
E
Q
A
S
D
T
A
N
Y
G
K
A
R
S
W
Y
-
L
K
A
-
Q
---
H
I
A
P
K
N
G
R
-----
P
Y
-
N
Q
L
-
A
L
-
L
----
A
V
--------
Y
-
T
R
--
R
-
K
-----
L
D
A
------
V
Y
Y
Y
-
M
-
R
S
L
A
A
S
N
P
I
L
T
-
A
K
-
E
S
L
M
----
S
L
F
E
E
T
K
R
K
A
E
Q
--
M
E
K
G
L
-
G
S
L
S
P
S
D
L
N
K
R
F
I
---
L
S
F
L
H
A
H
G
K
L
-
F
T
R
------
I
G
M
E
T
F
-
P
A
------
V
A
E
K
---
V
L
--
K
-
E
F
Q
V
------
L
L
Q
H
S
P
S
--
P
-
I
-
G
S
--
T
R
--
M
L
---
Q
L
M
T
I
N
M
F
A
V
H
N
S
-----
Q
---
R
S
V
-
I
Q
E
Q
A
------
A
A
L
---
G
L
A
M
F
S
-
L
L
----
V
------
R
R
C
T
-
C
L
---
L
K
E
S
L
S
S
P
---
E
D
Q
D
D
Q
D
D
-
I
-----
K
V
-
S
SFV
P
D
L
K
E
----
L
L
P
S
-----
V
K
V
-
W
S
D
W
M
--
L
G
Y
P
D
-----
T
--------
W
N
------
P
P
P
-
T
S
L
D
L
-
P
S
---
H
V
-
A
V
D
V
W
S
T
L
A
D
F
C
N
I
L
T
A
V
N
Q
S
E
V
P
L
Y
-----
K
D
P
D
---
D
D
L
T
-
L
------------
L
I
L
-
E
E
D
R
L
L
-
S
G
F
-
V
----
P
L
L
A
A
P
Q
D
P
C
Y
--
V
E
K
T
S
D
K
V
I
A
A
D
C
K
R
V
T
V
L
K
Y
F
L
E
A
L
C
G
QEEPLLAFKGG
K
Y
V
S
VAPV
29
Fugue
55.44
11%
-5
- C5 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
--------------------------
Y
N
S
S
Y
I
-
F
S
I
T
-
L
V
A
T
L
G
G
L
L
------
F
G
Y
D
T
A
V
I
S
G
---------
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
S
--------
A
A
N
S
L
L
G
F
--
C
V
A
--
S
-
A
-
L
-
I
G
C
I
-------
I
G
-
G
--
A
------------------
L
G
G
Y
C
S
-----
N
-
R
-
F
G
R
-
R
D
S
L
K
I
-
A
-
A
V
L
F
------
F
-------
I
S
G
V
---
G
S
A
WPELGFTSINPDN
T
V
P
V
Y
L
-
A
G
Y
V
P
E
--------------------
F
V
-
I
Y
--
R
I
I
G
G
--
I
-
G
V
G
L
---
A
-
S
---
M
-
L
S
P
-
M
Y
I
---
A
E
L
----
A
PAHI
R
G
K
L
-
V
S
F
--
N
Q
F
A
I
I
F
G
Q
L
L
V
-
Y
C
V
-
N
---
Y
F
I
A
R
S
G
D
-----
A
S
W
L
N
T
-
D
G
-
W
----
R
Y
--------
M
-
F
A
--
S
-
E
-----
C
-
I
------
P
A
L
L
-
F
-
L
M
L
L
Y
T
V
P
--
E
-
S
P
-
R
W
L
M
S
R
GK
Q
--
E
Q
A
E
G
I
L
R
K
--
I
M
-
G
N
-
T
L
A
T
Q
A
--
V
Q
E
I
K
---
H
S
L
D
H
G
R
K
T
G
-
G
R
L
------
L
M
F
G
V
G
-
V
I
------
V
I
G
V
---
M
L
--
S
-
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
A
--
S
T
--
D
I
---
A
L
L
Q
-------
T
I
-----
I
---
V
G
V
-
I
N
L
T
F
------
T
V
L
---
A
I
M
T
V
D
-
K
F
----
G
R
K
P
L
Q
I
I
G
A
L
-
G
M
---
A
I
G
M
F
S
L
G
---
T
A
F
Y
T
Q
A
P
-
G
-----
I
V
-
A
-----
L
L
S
----
M
L
F
Y
-----
V
A
A
-
F
A
M
S
W
--
G
P
V
C
W
-----
V
--------
L
L
-
S
E
IFP
N
A
I
-
R
G
K
A
L
-
A
I
---
A
V
-
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
---
P
M
M
D
K
N
S
W
L
-----
V
A
H
F
---
H
N
G
F
-
S
------------
Y
W
I
-
Y
G
C
M
G
V
-
L
A
A
-
L
----
F
M
W
K
F
V
P
E
T
K
G
KT
L
E
E
L
E
A
L
WE--------------------------------------
24
Fugue
54.38
18%
-1
- C1 -
1XIP
-
NU159_YEAST
A:
[1-381]
-------------------------
A
S
S
L
K
D
E
-
V
P
-
T
-
E
T
S
E
D
F
G
F
K
------
F
L
----------------
G
Q
K
Q
I
L
P
S
F
N
E
K
L
P
----------------
F
A
S
L
Q
--
N
L
D
I
S
N
-
S
-
K
-
S
L
F
V
-------
A
A
-
S
-------------------------------------
G
S
-
K
A
V
V
G
E
-
L
-
Q
L
L
R
------
D
-------
H
I
T
S
---
D
S
--------------
T
P
L
T
---------------------------------
F
--
K
W
E
K
E
--
I
-
P
-
D
V
---
I
-
F
---
V
-
C
F
H
-----------------------------
G
D
Q
V
L
V
S
T
R
N
A
L
-
Y
S
L
-
D
---
L
E
E
L
S
E
F
R
-----
T
V
-
T
S
F
-
E
K
-
P
-----------------------------------------------
V
F
Q
L
K
--
N
-
V
N
-
N
T
L
V
----
I
--
L
N
S
V
N
D
L
S
A
--
L
D
L
R
T
-
K
S
T
K
Q
L
--
A
Q
N
V
T
---
S
F
D
V
T
N
S
Q
L
A
-
V
L
L
------
K
D
R
S
F
Q
-
S
F
------
A
W
R
N
---
G
---
E
M
E
K
Q
F
------
E
F
S
L
P
S
E
L
E
E
-
L
-
P
V
--
E
E
YS
P
L
---
S
V
T
I
-------
L
S
-----
P
---
Q
-
D
-
F
L
A
V
F
------
G
N
V
---
I
S
E
T
D
D
-
E
V
----
S
------
Y
D
Q
K
M
Y
I
---
I
K
H
I
D
----------
G
S
A
S
-
F
-----
Q
E
-
T
-----
F
D
I
----
T
P
P
F
GQIVR
F
P
Y
M
Y
K
V
T
L
--
S
G
L
I
E
PD
A
N
V
N
--------
V
L
-
A
S
---
S
C
S
-
S
E
V
S
I
-
W
D
---
S
K
-
Q
V
I
E
P
S
Q
D
S
E
R
A
V
L
---
P
I
S
E
E
T
D
K
D
-----
T
N
P
I
---
G
V
A
V
-
D
------------
V
V
T
-
S
G
L
P
L
V
-
Y
I
L
-
N
----
N
E
-----
G
S
L
Q
--
I
V
G
L
F
H
-----------------------------------------
23
Fugue
52.44
9%
-24
- C2 -
1Y8Q
3
SAE2_HUMAN
B:
[6-550]
-------------------------
G
L
P
R
E
L
A
-
E
A
V
A
G
G
R
V
L
V
V
G
A
G
-------
G
I
G
C
E
L
L
K
N
L
V
L
T
G
-
F
S
H
I
D
L
I
D
L
D
T
I
D
V
S
N
L
N
R
Q
F
LFQKKHVG
R
S
K
A
Q
V
A
K
--
E
S
V
L
Q
F
-
Y
-
P
-
K
A
N
I
-------
V
A
-
Y
--
H
DSIMNPDYN
V
E
F
F
R
QFI
L
V
M
N
A
L
D
-----
N
-
R
-
A
A
R
-
N
H
V
N
R
M
-
C
-
L
A
A
D
------
V
-------
P
L
I
E
---
S
G
--------------
T
A
G
Y
L
G
-
Q
V
T
T
I
K
K
GVTECYECHPKPT
Q
R
T
F
P
G
A
T
-
I
R
--
N
T
P
S
E
--
P
-
I
H
C
I
---
V
-
W
---
A
-
K
Y
L
-
F
N
Q
---
L
F
G
----
E
-----
E
D
A
-
D
Q
E
--
V
S
P
D
R
A
D
P
E
A
A
W
-
E
T
K
-
E
---
W
A
K
S
T
G
Y
D
-----
P
V
-
K
L
F
-
T
K
-
L
----
F
K
--------
D
-
D
I
--
R
-
Y
-----
L
-
L
------
T
M
D
K
-
L
-
W
R
K
R
K
P
P
V
--
P
-
L
D
-
W
A
E
V
----
Q
--
S
Q
L
----
G
L
--
K
D
Q
Q
V
-
L
D
V
K
S
Y
--
A
R
L
F
S
---
K
S
I
E
T
L
R
V
H
L
-
A
E
K
------
G
D
G
A
E
L
-
I
W
D
K----
D
D
P
S
---
A
M
--
D
-
F
V
T
S
------
A
A
N
L
R
M
H
I
F
S
-
M
-
N
M
K
S
R
F
--
D
I
---
K
S
M
A
-------
G
N
I
I
P
A
I
A
---
T
T
N
-
A
V
I
A
G
------
L
I
V
---
L
E
G
L
K
I
-
L
S
----
G
------
K
I
D
Q
-
C
R
---
T
I
F
L
N
K
Q
P
---
N
P
R
K
K
L
L
V
-
P
-----
C
A
-
L
-----
D
P
P
----
N
P
N
C
YVCA-
S
K
P
-
E
V
T
V
R
--
L
N
V
H
K
VT---
V
--------
L
T
-
L
Q
---
D
K
I
-
V
K
E
K
F
-
A
M
---
V
A
-
P
D
V
Q
I
E
D
G
K
G
T
I
L
I
---
S
S
E
E
G
E
T
E
A
-----
N
N
H
K
---
K
L
S
E
-
F
GIRNG
S
R
L
Q
A
D
D
F
L
Q
-
D
Y
T
L
L
I
-
N
I
L
-
H
----
S
E
D
L
G
K
D
V
E
F
E
--
V
V
G
D
A
------------------------------------------
28
Fugue
46.81
20%
21
- C4 -
4U0O
4
LIPA2_THEEB
B:
[8-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
W
L
R
I
S
T
V
Q
-
R
L
V
-
R
---
Q
Y
G
I
H
T
I
C
-----
E
E
-
G
R
C
-
P
N
-
R
----
G
E
--------
C
-
Y
G
--
Q
-
K
-----
T
-
A
------
T
F
L
L
-
L
-
G
------
P
--
T
-
C
T
-
R
A
C
----------
A
F
C
Q
V
-----
E
K
G
H
-
A
P
A
A
V
D
--
P
E
E
P
T
---
K
I
A
A
A
V
A
T
L
G
-
L
R
Y
------
V
V
L
T
S
V
-
A
R
------
D
D
L
P
---
D
Q
--
G
-
A
G
Q
F
------
V
A
T
M
A
A
I
R
Q
R
-
C
P
G
T
--
E
I
--
E
V
LSP
D
F
R
M
-------
D
R
-----
G
RLS
Q
R
D
-
C
I
A
Q
I
------
V
A
A
---
Q
P
A
C
Y
N
--
H
----
N
------
L
E
T
V
-
R
R
---
L
Q
G
P
V
R
R
G
ATY
E
S
S
L
R
V
L
A
-
T
-----
V
K
-
E
-----
L
N
P
----
D
I
P
T
-----
K
S
G
-
L
M
L
G
L
--
G
E
T
E
A
-----
E
--------
I
I
-
E
T
---
L
K
D
-
L
R
R
V
G
-
C
D
---
R
L
-
T
L
G
Q
Y
L
-------------
P
P
S
L
S
H
L
-----
P
V
V
K
---
Y
W
T
P
-
E
------------
E
F
N
-
T
L
G
N
I
A
-
R
E
L
-
G
FSHV
R
S
G
P
L
V
R
S
S
Y
H
--
A
A
E
--------------------------------------------
7
PsiBlast_PDB
45.44
20%
19
- C6 -
1KMH
-
ATPA_SPIOL
A:
[329-471]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
---
I
P
--------------
T
N
V
I
S
I
-
T
D
G
Q
I
F
--------------------
L
S
-
A
D
--
L
F
N
A
G
--
I
R
P
A
-----------------
I
N
V
---
G
I
S
----
V
-----
S
R
V
-
G
----
S
A
A
Q
I
K
A
M
K
K
V
A
-
G
K
L
-
K
---
L
E
-
L
A
Q
F
A
-----
E
L
-
E
A
F
-
A
Q
-
F
ASDL
D
K
--------
A
-
T
Q
--
N
-
Q
-----
L
-
A
------
R
G
Q
R
-
L
-
R
---------------
E
L
L
----
K
--
Q
P
Q
S
A
P
L
T
V
--
E
E
Q
V
M
-
T
I
Y
T
G
T
--
N
G
Y
L
D
---
S
L
E
L
D
Q
V
R
K
Y
-
L
V
E
------
L
R
T
Y
V
K
-
T
N
------
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.81
20%
17
- C6 -
1FX0
-
ATPA_SPIOL
A:
[329-471]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
---
I
P
--------------
T
N
V
I
S
I
-
T
D
G
Q
I
F
--------------------
L
S
-
A
D
--
L
F
N
A
G
--
I
R
P
A
-----------------
I
N
V
---
G
I
S
----
V
-----
S
R
V
-
G
----
S
A
A
Q
I
K
A
M
K
K
V
A
-
G
K
L
-
K
---
L
E
-
L
A
Q
F
A
-----
E
L
-
E
A
F
-
A
Q
-
F
ASDL
D
K
--------
A
-
T
Q
--
N
-
Q
-----
L
-
A
------
R
G
Q
R
-
L
-
R
---------------
E
L
L
----
K
--
Q
P
Q
S
A
P
L
T
V
--
E
E
Q
V
M
-
T
I
Y
T
G
T
--
N
G
Y
L
D
---
S
L
E
L
D
Q
V
R
K
Y
-
L
V
E
------
L
R
T
Y
V
K
-
T
N
------
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
38.57
26%
31
- C6 -
3HFS
1
?
A:
[24-136]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
----
V
-----
K
L
L
-
L
Q
K
--
G
Y
A
V
N
T
T
V
R
D
P
D
-
N
Q
K
-
K
---
V
S
H
L
L
E
L
Q
-----
E
L
-
G
D
L
-
K
I
-
F
----
R
A
--------
D
-
L
T
--
D
-
E
-----
L
-
S
------
F
-----------
E
A
P
--
I
-
A
G
-
C
D
F
V
----
F
--
H
V
A
--------------
T
P
V
H
---------------
I
K
P
A
I
Q
G
-
V
V
N
------
V
M
K
A
C
T
-
R
A
------
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
37.04
26%
32
- C6 -
2RH8
1
?
A:
[24-129]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
----
V
-----
K
L
L
-
L
Q
K
--
G
Y
A
V
N
T
T
V
R
D
P
D
-
N
Q
K
-
K
---
V
S
H
L
L
E
L
Q
-----
E
L
-
G
D
L
-
K
I
-
F
----
R
A
--------
D
-
L
T
--
D
-
E
-----
L
-
S
------
F
-----------
E
A
P
--
I
-
A
G
-
C
D
F
V
----
F
--
H
V
A
--------------
T
P
V
H
F
--------------
I
K
P
A
I
Q
G
-
V
V
N
------
V
M
K
A
C
T
-
R
A
------
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
32.95
26%
19
- C6 -
3ML1
3
NAPA_CUPNH
A:
[356-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
------
N
-------
N
M
V
Y
---
N
L
--------------
H
L
L
T
G
K
-
I
A
-------------------------
T
-
P
G
--
N
S
P
F
S
--
L
-
T
G
Q
P
---
S
-
A
---
C
-
G
T
A
-
R
E
V
---
G
T
F
----
S
-----
H
R
L
-
P
A
D
--
M
V
V
T
N
P
K
H
R
E
E
A
-
E
R
I
W
K
---
L
P
P
----
G
-----
T
I
-
P
D
K
-
P
G
-
Y
----
D
A
--------
V
-
L
Q
--
N
-
R
-----
M
-
L
------
K
D
G
K
-
L
-
N
A
Y
W
V
Q
------------
V
----
N
--
N
N
M
Q
A
A
A
N
L
--
M
E
E
G
L
-
P
G
Y
R
N
P
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
32.07
26%
18
- C6 -
3O5A
7
NAPA_CUPNH
A:
[356-475]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
------
N
-------
N
M
V
Y
---
N
L
--------------
H
L
L
T
G
K
-
I
A
-------------------------
T
-
P
G
--
N
S
P
F
S
--
L
-
T
G
Q
P
---
S
-
A
---
C
-
G
T
A
-
R
E
V
---
G
T
F
----
S
-----
H
R
L
-
P
A
D
--
M
V
V
T
N
P
K
H
R
E
E
A
-
E
R
I
W
K
---
L
P
P
----
G
-----
T
I
-
P
D
K
-
P
G
-
Y
----
D
A
--------
V
-
L
Q
--
N
-
R
-----
M
-
L
------
K
D
G
K
-
L
-
N
A
Y
W
V
Q
------------
V
----
N
--
N
N
M
Q
A
A
A
N
L
--
M
E
E
G
L
-
P
G
Y
R
N
P
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
30.90
13%
0
- C7 -
3U07
-
?
A:
[307-418]
-----------------------------------------------------------------------------------------------------
W
G
L
P
P
--
I
E
A
S
Y
R
-
K
-
S
-
D
F
D
S
IGQKLDG
S
K
-
H
--
D
------------------
Y
V
M
R
F
K
A
----
P
-
N
-
V
S
E
-
F
W
S
V
T
I
-
Y
-
G
N
D
N
------
R
L
M
A
K
N
DL
N
R
H
S
---
R
G
--------------
D
R
T
M
K
A
D
K
D
G
Y
Y
T
--------------------
I
Y
M
S
A
--
N
E
-------
K
G
R
A
DDP
N
-
F
---
L
-
P
V
P
-
E
K
P
---
F
Y
A
----
I
-----
M
R
F
-
Y
G
A
--
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------