@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1887: (2016-03-29 )
MKTFQLVATAASGLEAIVGKEVARLGYDPKVENGKVYFEGDLSAIARANLWLRVADRVKIVVGVFKATTFDELFEKTKALPWEDYLPLDAQFPVAGKSVKSTLYSVPDCQAIVKKAIVNRVSEKYRRSGRLMETGALFKLEVSILKDEVTLTIDTSGAGLHKRGYRLAQGSAPIKETMAAALVLLTSWHPDRPFYDPVCGSGTIPIEAALIGQNIAPGFNREFVSETWDWMPKQIWADARQEAEDLANYDQPLNIIGGDIDARLIEIAKQNAVEAGLGDLITFRQLQVADFQTEDEYGVVVANPPYGERLEDEEAVRQLYREMGIVYKRMPTWSVYVLTSYELFEEVYGKKATKKRKLYNGYLRTDLYQYWGPRKPRPKKED
Atome Classification :
(20 SA)
.........10........20..----..----.-.---.--.-30--...------......40------------------.-------------........50........60...--..---------..---------.70.......-------.80........90....-...-.100.....--..110.......120.....--..130.........140.......150.....-.-.160.......170.......180.......190.......200.......210.......220.-.......230.......240...-----....250.---......260.......270.......280.......290.-.-----.-.....300.......310---------------------.---------------.-------------------------.....320-..-....-.-----330.-.......340...---.---..---.350-.........360.......370.......380------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
T
F
Q
L
V
A
T
A
AS
G
L
E
A
I
V
G
K
E
V
A
----RL----G-Y---D--P-K---VEN------
G
K
V
Y
F
EG-------------------
D
-------------
L
S
A
I
A
R
A
N
L
W
L
R
VAD
R
V
K
I
V
V
G
V--FK---------AT---------
T
F
D
E
L
F
E
K
TK-------ALPWEDYLPLDAQFPVA-
G
K
S
-
V
K
S
T
LYSVP--
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R--SGR--LMETG
A
L
F
K
L
E
V
S
I
L
KD
E
V
T
L
T
I
DTSG-A-GLHKRG
Y
R
LAQGSA
P
I
K
E
T
M
A
A
A
L
V
L
LTSWHPDRPFYDPVCGSG
T
I
P
I
E
A
A
LIGQNIAPGF
N
R
-
E
-
F
V
S
E
T
W
DW
M
P
K
Q
I
W
A
D
A
R
Q
E
A
E
D
-----
L
ANYDQP
L
---
N
IIGGD
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
AG
L
G
D
L
I
T
F
R
Q
L
Q
V
ADF-Q-T-----E-DEY
G
V
V
V
ANPPYGERL
E
D
---------------------
E
---------------
E
-------------------------
A
V
R
Q
L
Y
R
E
-
M
G
-
I
V
Y
K-R-----M-PT-
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
Y---GK---KATKK
R
K
L
YN
G
Y
L
R
T
D
L
Y
Q
YWGPRKPRPKKED------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
99.91
99%
-113
- C4 -
3K0B
2
?
A:
[12-384]
M
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
A
----
R
L
----
G
-
Y
---
D
--
P
-
K
---
V
E
N
------
G
K
V
Y
F
E
G
-------------------
D
-------------
L
S
A
I
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
--
F
K
---------
A
T
---------
T
F
D
E
L
F
E
K
T
K
-------
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
-
G
K
S
-
V
K
S
T
L
Y
S
V
P
--
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
--
S
G
R
--
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
-----
L
A
N
Y
D
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
-
Q
-
T
-----
E
-
D
E
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
-------------------------
A
V
R
Q
L
Y
R
E
-
M
G
-
I
V
Y
K
-
R
-----
M
-
P
T
-
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
Y
---
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
T
D
L
Y
Q
Y
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.35
98%
-113
- C4 -
3K0B
2
?
A:
[13-384]
-
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
A
----
R
L
----
G
-
Y
---
D
--
P
-
K
---
V
E
N
------
G
K
V
Y
F
E
G
-------------------
D
-------------
L
S
A
I
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
--
F
K
---------
A
T
---------
T
F
D
E
L
F
E
K
T
K
-------
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
-
G
K
S
-
V
K
S
T
L
Y
S
V
P
--
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
--
S
G
R
--
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
-----
L
A
N
Y
D
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
-
Q
-
T
-----
E
-
D
E
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
-------------------------
A
V
R
Q
L
Y
R
E
-
M
G
-
I
V
Y
K
-
R
-----
M
-
P
T
-
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
Y
---
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
T
D
L
Y
Q
Y
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.64
54%
-97
- C4 -
3LDG
1
?
A:
[3-380]
-
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
----
N
L
----
G
-
L
---
D
--
C
-
Q
---
V
E
N
------
G
R
V
L
F
K
G
-------------------
N
-------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
--
F
P
---------
A
R
---------
T
F
E
E
L
F
Q
G
V
Y
-------
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
-
V
K
S
K
L
H
N
E
P
--
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
PD
S
V
P
--
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
-----
Q
A
D
Y
D
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
-
K
-
T
-----
N
-
K
I
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
-------------------------
A
V
D
I
L
Y
N
E
-
M
G
-
E
T
F
A
-
P
-----
L
-
K
T
-
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
F
---
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
V
D
L
Y
Q
F
Y
G
Q
R
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
85.09
55%
-97
- C4 -
3LDG
1
?
A:
[3-380]
-
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
----
N
L
----
G
-
L
---
D
--
C
-
Q
---
V
E
N
------
G
R
V
L
F
K
G
-------------------
N
-------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
--
F
P
---------
A
R
---------
T
F
E
E
L
F
Q
G
V
Y
-------
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
-
K
A
K
S
V
K
S
K
L
H
N
E
P
--
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
--
P
D
S
VP
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
-----
Q
A
D
Y
D
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
-
K
-
T
-----
N
-
K
I
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
-------------------------
A
V
D
I
L
Y
N
E
-
M
G
-
E
T
F
A
-
P
-----
L
-
K
T
-
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
F
---
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
V
D
L
Y
Q
F
Y
G
Q
R
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.66
48%
-97
- C4 -
3LDU
12
?
A:
[5-383]
-
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
T
----
N
L
----
G
-
Y
---
E
--
I
I
K
---
T
E
D
------
G
R
I
T
Y
K
T
-------------------
D
-------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
--
F
E
---------
A
K
---------
S
F
D
E
L
F
E
N
T
K
-------
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
K
A
S
S
-
I
K
S
K
L
Y
S
T
P
--
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
--
D
G
L
--
L
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
-----
K
I
D
N
E
S
K
F
---
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
-
K
-
S
-----
E
-
D
E
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
---------------------
K
---------------
D
-------------------------
S
V
K
Q
L
Y
K
E
-
L
G
-
Y
A
F
R
-
K
-----
L
-
K
N
-
W
S
Y
Y
L
I
T
S
Y
E
D
F
E
---
Y
---
E
F
---
G
Q
---
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
T
N
F
F
Q
Y
P
G
P
K
P
P
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
84.28
48%
-96
- C4 -
3LDU
12
?
A:
[5-383]
-
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
T
----
N
L
----
G
-
Y
---
E
--
I
I
K
---
T
E
D
------
G
R
I
T
Y
K
T
-------------------
D
-------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
--
F
E
---------
A
K
---------
S
F
D
E
L
F
E
N
T
K
-------
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
-
K
A
S
S
I
K
S
K
L
Y
S
T
P
--
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
--
D
G
L
--
L
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
-----
K
I
D
N
E
S
K
F
---
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
-
K
-
S
-----
E
-
D
E
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
---------------------
K
---------------
D
-------------------------
S
V
K
Q
L
Y
K
E
-
L
G
-
Y
A
F
R
-
K
-----
L
-
K
N
-
W
S
Y
Y
L
I
T
S
Y
E
D
F
E
---
Y
---
E
F
---
G
Q
---
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
T
N
F
F
Q
Y
P
G
P
K
P
P
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
75.16
32%
-76
- C4 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
-
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
----
N
L
----
G
A
V
---
E
--
C
-
Q
---
V
V
Q
------
G
G
V
H
F
K
G
-------------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
--
C
K
---------
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
-
F
S
G
-
L
N
D
T
I
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
--
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
-----
R
A
R
K
G
L
A
E
YS
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
-
T
-
N
PLP--
K
-
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
-------------------------
A
L
I
A
L
H
S
L
-
L
G
-
R
I
M
K
-
N
-----
Q
-
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
---
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
--
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
M
V
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
GIECYRLYDADLPEYN
V
A
V
D
R
Y
AD
W
V
V
V
Q
E
Y
AH
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIAPNK
L
V
L
K
T
REE
K
G
E
F
L
E
V
T
E
YN
A
H
L
W
V
N
LTDYLDTGLFLDH
R
I
A
R
R
M
L
G
Q
M
SKGKD
F
L
N
L
FSYTG
S
A
T
V
H
A
G
L
G
GAR
S
T
T
T
V
D
MS
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
GLTGRA
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
ANEQFD
L
I
F
I
D
P
P
TFSAFDVQRD
H
L
A
L
M
K
D
L
K
R
L
LRAG
G
T
I
M
F
S
N
NKRGFRMD
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
4
PsiBlast_PDB
69.62
33%
-82
- C4 -
3V97
3
RLMKL_ECOLI
A:
[30-404]
--------------------------------------------
Q
---
V
V
Q
------
G
G
V
H
F
K
G
-------------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
--
C
K
---------
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
-
F
S
G
-
L
N
D
T
I
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
--
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
-----
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
-
T
-
N
PLP--
K
-
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
-------------------------
A
L
I
A
L
H
S
L
-
L
G
R
I
M
K
N
-
Q
-----
F
-
G
G
-
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
---
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
68.09
26%
-92
- C4 -
3TM4
1
?
A:
[1-370]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
----
L
L
L
K
K
L
G
-
I
---
S
--
F
-
Q
---
I
E
E
KPLGIE
G
R
L
L
L
E
A
-------------------
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
--
E
K
FNGIEKDE
S
E
E
---------
A
L
K
R
I
K
D
F
V
S
-------
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
-
S
F
R
-
K
G
D
H
N
I
T
S
I
--
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
----
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
G
------------------------------------------------
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
-
S
Q
Y
-----
V
-
D
S
V
D
F
A
I
S
N
L
P
Y
G
S
M
--
I
---------------------
P
---------------
D
-------------------------
L
Y
M
K
F
F
N
E
-
L
A
-
K
V
---------
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
---
A
I
---
A
E
N
GF
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
V
V
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_CBE
66.90
33%
-86
- C4 -
3V97
3
RLMKL_ECOLI
B:
[30-407]
--------------------------------------------
Q
---
V
V
Q
------
G
G
V
H
F
K
G
-------------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
--
C
K
---------
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
----------
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
--
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
------
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
---
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
-----
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
-
T
-
N
PLP--
K
-
G
P
Y
G
T
V
L
S
N
P
P
Y
-----
S
---------------------
E
---------------
P
-------------------------
A
L
I
A
L
H
S
L
-
L
G
R
I
M
K
N
-
Q
-----
F
-
G
G
-
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
---
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
65.89
26%
-88
- C4 -
3TM4
1
?
A:
[1-365]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
----
L
L
L
K
K
L
G
-
I
---
S
F
Q
I
E
E
KPL
G
I
E
------
G
R
L
L
L
E
A
-------------------
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
--
E
K
---------
F
N
GIEKDE
S
E
E
A
L
K
R
I
K
D
F
V
S
-------
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
-
S
F
R
-
K
G
D
H
N
I
T
S
I
--
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
-
G
---
T
P
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
-
D
S
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
-
D
G
G
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
---------------------------------------------
S
G
---
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
-
S
-
Q
-----
Y
V
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
-------------------------
M
I
P
D
L
Y
M
K
-
F
F
-
N
E
L
A
K
V
-----
L
E
K
R
-
G
V
F
I
T
-
T
E
K
K
A
I
E
E
A
I
A
---
E
N
---
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
V
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
65.62
33%
-89
- C4 -
3V8V
2
RLMKL_ECOLI
B:
[29-407]
--------------------------------------------
Q
---
V
V
Q
------
G
G
V
H
F
K
G
-------------------
D
-------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
--
C
-----------
Y
---------
S
D
L
D
L
Y
L
G
V
Q
-------
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
----------
R
N
S
Q
--
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
--
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
-------
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
----
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
-----
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
-
T
-
N
PLP--
K
-
G
P
Y
G
T
V
L
S
N
P
P
Y
-----
S
---------------------
E
---------------
P
-------------------------
A
L
I
A
L
H
S
L
-
L
G
R
I
M
K
N
-
Q
-----
F
-
G
G
-
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
L
---
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.73
25%
-81
- C4 -
3TM5
1
?
A:
[1-362]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
---
S
--
F
-
Q
---
I
E
E
------
K
P
L
G
I
E
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
-------------
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
---------
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
--
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
----------------
G
-----
I
E
K
Y
R
K
H
L
-----
I
G
----------
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-
Y
-----
V
-
D
S
V
D
F
A
I
S
N
L
P
Y
G
L
K
I
G
----------------------
K
---------------
S
-------------------------
M
I
P
D
L
Y
M
K
F
F
N
-
E
L
A
K
-
V
-----
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
---
A
I
A
E
N
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.93
25%
-86
- C4 -
3TLJ
2
?
A:
[1-362]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
---
S
--
F
-
Q
---
I
E
E
------
K
P
L
G
I
E
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
-------------
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
---------
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
--
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
----------------
G
-----
I
E
K
Y
R
K
H
L
-----
I
G
----------
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-
Y
-----
V
-
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
-------------------------
M
I
P
D
L
Y
M
K
F
F
N
-
E
L
A
K
-
V
-----
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
---
A
I
A
E
N
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.63
25%
-85
- C4 -
3TM4
1
?
A:
[1-362]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
---
S
--
F
-
Q
---
I
E
E
------
K
P
L
G
I
E
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
-------------
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
N
---------
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
---
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
P
--
L
V
N
--
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
----------------
G
-----
I
E
K
Y
R
K
H
L
-----
I
G
----------
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-
Y
-----
V
-
D
S
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
-------------------------
M
I
P
D
L
Y
M
K
F
F
N
-
E
L
A
K
-
V
-----
L
-
E
K
-
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
---
A
I
A
E
N
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
58.42
22%
-78
* C4 *
3TMA
1
?
A:
[19-352]
--
H
M
W
L
E
A
T
T
H
P
G
L
E
D
L
L
L
E
E
L
S
----
A
L
----
Y
-
P
G
E
G
A
--
E
V
D
---
A
R
K
------
G
R
V
R
I
P
R
-------------------
A
-------------
W
V
--
G
E
E
A
L
G
L
R
L
A
H
H
L
V
L
F
R
A
R
--
L
L
LSR------
E
D
---------
P
L
G
A
L
E
R
A
A
L
-------
A
L
P
W
P
E
L
E
G
-
A
G
S
F
R
V
E
-
A
R
R
-
E
G
E
H
P
F
T
S
P
--
E
V
E
R
R
V
G
E
A
L
H
R
A
Y
G
--------
V
P
--
V
D
L
K
R
P
A
V
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
F
P
K
-
A
A
L
R
G
S
L
T
P
V
L
A
Q
A
L
L
R
L
A
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
--------------------------------------------
P
T
S
---
P
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
L
S
-
W
I
R
F
L
R
A
D
A
R
H
L
-
P
-
R
-----
F
F
P
E
V
D
R
I
L
A
N
P
P
H
G
L
-------------------------
K
---------------
E
-------------------------
G
L
F
H
L
Y
W
D
-
F
L
-
R
G
A
L
A
L
L----
P
-
P
G
-
G
R
V
A
L
L
T
L
R
P
A
L
L
---
K
R
A
L
P
P
---
G
F
---
A
L
R
H
A
R
V
V
E
Q
G
G
V
Y
P
R
V
F
V
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
42.84
18%
-72
- C4 -
3UFB
-
?
A:
[202-367]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
P
V
V
R
F
M
V
E
V
M
D
P
Q
L
G
E
S
V
L
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
C
K
T
----------------
V
E
D
----------------
R
E
V
L
Q
E
S
---
S
I
F
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
N
L
L
L
H
G
L
E
Y
-
P
R
I
D
P
E
N
S
L
R
F
-
P
-
L
REMGD
K
-
D
R
V
D
V
I
L
T
N
P
P
F
G
G
E
E
E
K
---------------------
G
---------------
I
L
G
N
F
PEDMQTAE-------------
T
A
M
L
F
L
Q
L
-
I
M
-
R
K
L
K
-
R
PGHGS
D
-
N
G
-
G
R
A
A
V
V
V
P
N
G
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
42.59
13%
-80
- C4 -
2IH2
5
MTTA_THEAQ
A:
[21-169]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
T
P
P
E
V
V
D
F
M
V
S
L
A
E
A
P
R
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
R
E
A
H
G
T
--------------------------------------------
A
Y
---
R
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W
----------
A
E
G
I
L
A
D
F
L
L
W
-
E
-
P
-----
G
-
E
A
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
---------------------
S
---------------
K
YP
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
STWKGKYN
L
Y
G
A
F
L
E
K
-
A
V
-
R
L
L
K
---------
P
G
-
G
V
L
V
F
V
V
P
A
T
W
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
42.56
15%
-78
- C4 -
2B3T
1
PRMC_ECOLI
A:
[94-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
E
C
L
V
E
Q
A
L
A
R
L
P
-
E
Q
P
C
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
---------------------------------------------
D
C
---
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
A
I
K
-
N
I
H
I
L
Q
S
D
W
F
S
A
-
L
-
A
-----
G
-
Q
Q
F
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
H
L
Q
Q
GDVRFEPLTALVAADSG
M
---------------
A
-------------------------
D
I
V
H
I
I
E
Q
-
S
R
-
N
A
L
V
---------
S
G
-
G
F
L
L
L
E
H
G
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
41.66
21%
-85
- C4 -
1NV8
2
PRMC_THEMA
A:
[103-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
P
E
T
E
E
L
V
E
L
A
L
E
L
I
R
K
Y
G
I
K
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
----------------------------------------------
D
A
---
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
G
V
S
D
R
F
F
V
R
K
G
E
F
L
E
P
-
F
-
K
EK---
F
-
A
S
I
E
M
I
L
S
N
P
P
Y
V
K
S
S
A
H
---------------------
L
PKDVLFEPPEALFGG
E
-------------------------
D
G
L
D
F
Y
R
E
-
F
F
-
G
R
Y
D
---------
T
S
-
G
K
I
V
L
M
E
I
G
E
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------