@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00390: (2016-06-01 )
MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTITRAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKSPKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAEVARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNEPSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN
Atome Classification :
(20 SA)
.........10...----------.----------.---...20........30........40........50----..----.----.----....60....---....70----.-------------------.......80..--------.--.....90.......----.100.----.......110.......120---........130......-.140.--------------------------....-..-150.......160....-.--..170.......180-.-.......190.......200....-----...210-------------.---------------------------.----.----....220.......230.......240.......250...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLFDTHAHL
N
A
E
Q
Y----------D----------T---
D
L
E
E
V
I
E
R
A
K
A
E
K
V
E
R
I
V
V
V
GFDR
P
T
I
T
R
A
M
E
M
I
E
----EY----
D
----
F
----
I
Y
A
AIGWHPV---DAIDM
T
----
E
-------------------
E
D
L
A
W
I
K
E
LSA--------H--
E
K
V
V
A
I
GEMGLDYH----WDK-
S
----
P
K
D
I
Q
K
E
V
F
R
N
Q
I
A
LAKEV----NL
P
I
I
I
HNRDA
T
E
D
V
V
T
-
I
L
K
EE--------------------------
G
A
E
A
-
V
G
-
G
I
M
H
CFTG
S
A
E
V
A
R
E
C
M
-K--
M
N
F
Y
L
SFG
G
P
V
TF-K-N-AK
K
P
K
E
V
V
K
EIPND
R
L
L
I
ETDCPF-----LTPHPF-------------R---------------------------G----K----RNE
P
S
Y
V
K
Y
V
A
E
Q
I
A
E
L
K
E
M
T
F
E
E
I
A
S
I
T
T
E
N
A
K
R
L
FRIN
1
PsiBlast_PDB
99.91
64%
-114
- C2 -
2GZX
2
?
A:
[2-254]
-
L
I
D
T
H
V
H
L
N
D
E
Q
Y
----------
D
----------
D
---
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
R
A
M
K
L
I
D
----
E
Y
----
D
----
F
----
L
Y
G
I
I
G
W
H
P
V
---
D
A
I
D
F
T
----
E
-------------------
E
H
L
E
W
I
E
S
L
A
Q
--------
H
--
P
K
V
I
G
I
G
E
M
G
L
D
Y
H
----
W
D
K
-
S
----
P
A
D
V
Q
K
E
V
F
R
K
Q
I
A
L
A
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
-
I
L
L
E
E
--------------------------
H
A
E
E
-
V
G
-
G
I
M
H
S
F
S
G
S
P
E
I
A
D
I
V
T
N
K
--
L
N
F
Y
I
S
L
G
G
P
V
T
F
-
K
-
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
P
H
P
Y
-------------
R
---------------------------
G
----
K
----
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
--
24
HHSearch
98.38
64%
-113
- C2 -
2GZX
2
?
A:
[2-254]
-
L
I
D
T
H
V
H
L
N
D
E
Q
Y
----------
D
----------
D
---
D
L
S
E
V
I
T
R
A
R
E
A
G
V
D
R
M
F
V
V
G
F
N
K
S
T
I
E
R
A
M
K
L
I
D
----
E
Y
----
D
----
F
----
L
Y
G
I
I
G
W
H
P
V
---
D
A
I
D
F
T
----
E
-------------------
E
H
L
E
W
I
E
S
L
A
Q
--------
H
--
P
K
V
I
G
I
G
E
M
G
L
D
Y
H
----
W
D
K
-
S
----
P
A
D
V
Q
K
E
V
F
R
K
Q
I
A
L
A
K
R
L
----
K
L
P
I
I
I
H
N
R
E
A
T
Q
D
C
I
D
I
L
L
E
E
H
--------------------------
A
--
E
E
V
G
-
G
I
M
H
S
F
S
G
S
P
E
I
A
D
I
V
T
-
N
K-
L
N
F
Y
I
S
L
G
G
P
V
T
F
-
K
-
N
-
A
K
Q
P
K
E
V
A
K
H
V
S
M
E
R
L
L
V
E
T
D
A
P
Y
-----
L
S
P
H
P
Y
-------------
R
---------------------------
G
----
K
----
R
N
E
P
A
R
V
T
L
V
A
E
Q
I
A
E
L
K
G
L
S
Y
E
E
V
C
E
Q
T
T
K
N
A
E
K
L
F
N
--
2
PsiBlast_PDB
83.40
39%
-102
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-257]
F
L
V
D
S
H
C
H
L
D
G
L
D
Y
----------
E
----------
S
LHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
----
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
L
---
N
Q
N
D
------
P
-------------------
Y
D
V
E
D
L
R
R
L
A
A
--------
E
--
E
G
V
V
A
L
G
E
T
G
L
D
Y
Y
----
Y
T
P
-
E
----
T
K
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
-
I
L
R
E
E
--------------------------
K
V
T
D
-
C
G
-
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
-
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
-
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
P
V
P
H
-------------
R
---------------------------
G
----
K
----
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
28
HHSearch
82.69
40%
-98
- C2 -
1YIX
2
YCFH_ECOLI
A:
[2-256]
F
L
V
D
S
H
C
H
L
D
G
L
D
Y
ESL-------
H
----------
K
---
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
----
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
L
---
N
Q
N
D
P
-------------------------
Y
D
V
E
D
L
R
R
L
A
A
--------
E
--
E
G
V
V
A
L
G
E
T
G
L
D
Y
Y
----
Y
T
P
-
E
----
T
K
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
-
I
L
R
E
E
--------------------------
K
--
V
T
D
C
G
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
-
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
-
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
P
V
P
H
-------------
R
---------------------------
G
----
K
----
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
-
21
PsiBlast_CBE
82.61
39%
-96
- C2 -
1YIX
2
YCFH_ECOLI
B:
[2-257]
F
L
V
D
S
H
C
H
L
D
G
L
D
Y
----------
E
----------
S
LHK
D
V
D
D
V
L
A
K
A
A
A
R
D
V
K
F
C
L
A
V
A
T
T
L
P
S
Y
L
H
M
R
D
L
V
G
----
E
R
----
D
----
N
----
V
V
F
S
C
G
V
H
P
L
---
N
Q
N
D
------
P
-------------------
Y
D
V
E
D
L
R
R
L
A
A
--------
E
--
E
G
V
V
A
L
G
E
T
G
L
D
Y
Y
----
Y
T
P
-
E
----
T
K
V
R
Q
Q
E
S
F
I
H
H
I
Q
I
G
R
E
L
----
N
K
P
V
I
V
H
T
R
D
A
R
A
D
T
L
A
-
I
L
R
E
E
--------------------------
K
V
T
D
-
C
G
-
G
V
L
H
C
F
T
E
D
R
E
T
A
G
K
L
L
-
D
--
L
G
F
Y
I
S
F
S
G
I
V
T
F
-
R
-
N
-
A
E
Q
L
R
D
A
A
R
Y
V
P
L
D
R
L
L
V
E
T
D
S
P
Y
-----
L
A
P
V
P
H
-------------
R
---------------------------
G
----
K
----
E
N
Q
P
A
M
V
R
D
V
A
E
Y
M
A
V
L
K
G
V
A
V
E
E
L
A
Q
V
T
T
D
N
F
A
R
L
F
H
I
D
5
PsiBlast_PDB
82.21
30%
-99
- C2 -
1XWY
1
TATD_ECOLI
A:
[5-262]
-
M
F
D
I
G
V
N
L
T
S
S
Q
F
----------
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
----
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
H
---
D
S
S
Q
W
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
--------
Q
--
P
E
V
V
A
I
G
E
C
G
L
D
F
N
----
R
N
F
-
S
----
T
P
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
-
L
L
E
P
W
--------------------------
L
D
K
L
-
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
-
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
P
K
P
--------------
S
---------------------------
S
----
R
----
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
-
3
PsiBlast_PDB
81.63
40%
-97
- C2 -
1J6O
-
?
A:
[2-250]
---
D
T
H
A
H
L
H
F
H
Q
F
----------
D
----------
D
---
D
R
N
A
V
I
S
S
F
E
E
N
N
I
E
F
V
V
N
V
G
V
N
L
E
D
S
K
K
S
L
D
L
S
K
----
T
S
----
D
----
R
----
I
F
C
S
V
G
V
H
P
H
---
D
A
K
E
V
P
----
E
-------------------
D
F
I
E
H
L
E
K
F
A
K
--------
D
--
E
K
V
V
A
I
G
E
T
G
L
D
F
F
----
R
N
I
-
S
----
P
A
E
V
Q
K
R
V
F
V
E
Q
I
E
L
A
G
K
L
----
N
L
P
L
V
V
H
I
R
D
A
Y
S
E
A
Y
E
-
I
L
R
T
E
--------------------------
S
L
P
E
-
K
R
-
G
V
I
H
A
F
S
S
D
Y
E
W
A
K
K
F
I
-
D
--
L
G
F
L
L
G
I
G
G
P
V
T
Y
-
P
-
K
-
N
E
A
L
R
E
V
V
K
R
V
G
L
E
Y
I
V
L
E
T
D
C
P
F
-----
L
P
P
Q
P
F
-------------
R
---------------------------
G
----
K
----
R
N
E
P
K
Y
L
K
Y
V
V
E
T
I
S
Q
V
L
G
V
P
E
A
K
V
D
E
A
T
T
E
N
A
R
R
I
F
---
25
HHSearch
81.38
31%
-96
- C2 -
1XWY
1
TATD_ECOLI
A:
[5-263]
-
M
F
D
I
G
V
N
L
T
S
S
Q
F
----------
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
----
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
H
---
D
S
S
Q
W
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
--------
Q
--
P
E
V
V
A
I
G
E
C
G
L
D
F
N
----
R
N
F
-
S
----
T
P
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
-
L
L
E
P
W
--------------------------
L
D
K
L
-
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
-
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
-
E
R
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
-----
L
L
P
R
D
L
-------------
T
---------------------------
P
KPSS
R
----
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
A
22
PsiBlast_CBE
81.34
32%
-114
- C2 -
2Y1H
6
TATD3_HUMAN
B:
[6-263]
-
L
V
D
C
H
C
H
L
S
A
P
D
F
----------
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
----
R
Y
----
N
G---
F
----
V
L
P
C
L
G
V
H
P
V
---
Q
G
L
-------
D
-------------------
Q
R
S
V
T
L
K
D
L
D
V
A
L
P
I
I
E
N
Y
K
--
D
R
L
L
A
I
G
E
V
G
L
D
F
S
PRFA
G
T
G
-
E
----
Q
K
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
T
I
N
-
L
L
Q
E
Q
--------------------------
G
A
E
K
-
V
---
L
L
H
A
F
D
G
R
P
S
V
A
M
E
G
V
-
R
--
A
G
Y
F
F
S
I
--
P
P
S
I
-
I
-
R
-
S
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
P
E
---------------
K
---------------------------
Q
----
V
----
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
---
7
PsiBlast_PDB
80.60
30%
-94
- C2 -
4P5U
-
TATD_ECOLI
A:
[1-258]
-
M
F
D
I
G
V
N
L
T
S
S
Q
F
----------
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
----
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
H
---
D
S
S
Q
W
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
--------
Q
--
P
E
V
V
A
I
G
E
C
G
L
D
F
N
----
R
N
F
-
S
----
T
P
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
-
L
L
E
P
W
--------------------------
L
D
K
L
-
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
-
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
P
K
P
--------------
S
---------------------------
S
----
R
----
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
-
31
HHSearch
80.04
34%
-97
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[5-266]
G
L
V
D
C
H
C
H
L
S
A
P
D
F
----------
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
----
R
Y
----
N
G---
F
----
V
L
P
C
L
G
V
H
P
V
---
Q
-----RSVT
L
-------------------
K
D
L
D
V
A
L
P
I
I
E
N
Y
------
K
--
D
R
L
L
A
I
G
E
V
G
L
D
F
S
----
P
R
F
-
A
GT
G
E
Q
K
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
T
I
N
-
L
L
Q
E
Q
--------------------------
G
--
A
-
E
K
-
V
L
L
H
A
F
D
G
R
P
S
V
A
M
E
G
V
-
R
--
A
G
Y
F
F
S
I
P
P
S
I
I
R
-
S
----
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
P
E
K
------------------------------------------
Q
----
V
----
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
P
K
L
6
PsiBlast_PDB
79.96
30%
-94
- C2 -
4PE8
1
TATD_ECOLI
A:
[1-258]
-
M
F
D
I
G
V
N
L
T
S
S
Q
F
----------
A
----------
K
---
D
R
D
D
V
V
A
C
A
F
D
A
G
V
N
G
L
L
I
T
G
T
N
L
R
E
S
Q
Q
A
Q
K
L
A
R
----
Q
Y
----
S
----
S
----
C
W
S
T
A
G
V
H
P
H
---
D
S
S
Q
W
Q
----
A
-------------------
A
T
E
E
A
I
I
E
L
A
A
--------
Q
--
P
E
V
V
A
I
G
E
C
G
L
D
F
N
----
R
N
F
-
S
----
T
P
E
E
Q
E
R
A
F
V
A
Q
L
R
I
A
A
D
L
----
N
M
P
V
F
M
H
C
R
D
A
H
E
R
F
M
T
-
L
L
E
P
W
--------------------------
L
D
K
L
-
P
G
-
A
V
L
H
C
F
T
G
T
R
E
E
M
Q
A
C
V
-
A
--
H
G
I
Y
I
G
I
T
G
W
V
C
D
E
R
-
R
-
G
L
E
L
R
E
L
L
P
L
I
P
A
E
K
L
L
I
E
T
D
A
P
Y
LLPRD
L
T
P
K
P
--------------
S
---------------------------
S
----
R
----
R
N
E
P
A
H
L
P
H
I
L
Q
R
I
A
H
W
R
G
E
D
A
A
W
L
A
A
T
T
D
A
N
V
K
T
L
F
G
I
-
4
PsiBlast_PDB
79.92
32%
-114
- C2 -
2Y1H
5
TATD3_HUMAN
A:
[6-263]
-
L
V
D
C
H
C
H
L
S
A
P
D
F
----------
D
----------
R
---
D
L
D
D
V
L
E
K
A
K
K
A
N
V
V
A
L
V
A
V
A
E
H
S
G
E
F
E
K
I
M
Q
L
S
E
----
R
Y
----
N
G---
F
----
V
L
P
C
L
G
V
H
P
V
---
Q
------------------------------
R
S
V
T
L
K
D
L
D
V
A
L
P
I
I
E
N
Y
K
--
D
R
L
L
A
I
G
E
V
G
L
D
F
S
PRFA
G
T
G
-
E
----
Q
K
E
E
Q
R
Q
V
L
I
R
Q
I
Q
L
A
K
R
L
----
N
L
P
V
N
V
H
S
R
S
A
G
R
P
T
I
N
-
L
L
Q
E
Q
--------------------------
G
A
E
K
-
V
---
L
L
H
A
F
D
G
R
P
S
V
A
M
E
G
V
-
R
--
A
G
Y
F
F
S
I
--
P
P
S
I
-
I
-
R
-
S
G
Q
K
Q
K
L
V
K
Q
L
P
L
T
S
I
C
L
E
T
D
S
P
A
-----
L
G
P
E
---------------
K
---------------------------
Q
----
V
----
R
N
E
P
W
N
I
S
I
S
A
E
Y
I
A
Q
V
K
G
I
S
V
E
E
V
I
E
V
T
T
Q
N
A
L
K
L
F
---
30
HHSearch
78.99
28%
-102
- C2 -
3RCM
3
?
A:
[2-273]
Q
L
I
D
I
G
V
N
L
T
N
S
S
F
----------
H
----------
D
---
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
Q
A
L
E
L
C
Q
----
Q
L
DASG
A
----
H
----
L
F
A
T
A
G
V
H
P
H
---
D
A
K
A
W
D
----
T
-------------------
D
S
E
R
Q
L
R
L
L
L
S
--------
E
--
P
R
V
R
A
V
G
E
C
G
L
D
F
N
----
R
D
F
-
S
----
P
R
P
L
Q
E
K
A
L
E
A
Q
L
T
L
A
A
Q
L
----
R
L
P
V
F
L
H
E
R
D
A
S
E
R
L
L
A
-
I
L
K
D
Y
--------------------------
R
--
D
H
L
T
G
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
-
D
--
L
D
L
H
I
G
I
T
G
W
I
C
D
-
E
-
R
R
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
L
P
R
S
L
-------------
R
---------------------------
P
----
K
PKSG
R
N
E
P
A
F
L
P
E
V
L
R
E
V
A
L
H
R
G
E
S
A
E
H
T
A
A
H
T
T
A
T
A
R
D
F
F
Q
L
P
34
HHSearch
78.84
28%
-95
* C2 *
3E2V
3
?
A:
[13-393]
K
Y
Y
D
I
G
L
N
L
T
D
P
M
F
HGIYNGKQYH
P
----------
A
---
D
Y
V
K
L
L
E
R
A
A
Q
R
H
V
K
N
A
L
V
T
G
S
S
I
A
E
S
Q
S
A
I
E
L
V
S
S
V
K
D
L
S
----
P
L---
K
----
L
Y
H
T
I
G
V
H
P
C
---
C
V
N
E
F
A
-----E
A
Y
N
E
S
L
Y
A
K
V
I
S
NP
S
F
A
Q
G
K
L
K
E
L
Y
D
L
M
N
Q
Q
A
KPH--
D
--
T
S
F
R
S
I
G
E
I
G
L
D
Y
D
----
R
F
H
Y
S
----
S
K
E
M
Q
K
V
F
F
E
E
Q
L
K
I
S
C
L
N
D
K
L
S
S
Y
P
L
F
L
H
M
R
S
A
C
D
D
F
V
Q
-
I
L
E
R
F
V
V
G
F
T
D
EKDTFQLQKLSSSSG
F
Y
K
F
H
P
--
D
-
R
K
-
L
V
V
H
S
F
T
G
S
A
I
D
L
Q
K
L
L
-
N
L
S
P
N
I
F
I
G
V
N
G
C
S
L
R
-
T
----
E
E
N
L
A
V
V
K
Q
I
P
T
E
R
L
L
L
E
T
D
A
P
W
-----
C
E
I
K
R
T
HAS
F
Q
Y
L
A
K
Y
Q
E
V
R
DFEYPA
F
K
S
V
K
KNKLADKLNAE
E
L
Y
M
V
K
----
G
----
R
N
E
P
C
N
M
E
Q
V
A
I
V
V
S
E
V
K
D
V
D
L
A
T
L
I
D
T
T
W
K
T
T
C
K
I
F
G
--
23
HHSearch
78.75
30%
-100
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[4-259]
R
F
I
D
T
H
C
H
F
D
F
P
P
F
----------
S
----------
G
---
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
R
V
L
A
L
A
E
----
N
Y
----
Q
----
P
----
L
Y
A
A
L
G
L
H
P
G
---
M
L
E
K
H
S
----
D
-------------------
V
S
L
E
Q
L
Q
Q
A
L
E
--------
R
RP
A
K
V
V
A
V
G
E
I
G
L
D
L
F
----
G
D
D
-
P
----
Q
F
E
R
Q
Q
W
L
L
D
E
Q
L
K
L
A
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
L
A
M
-
H
L
K
R
H
--------------------------
D
--
L
-
P
R
T
G
V
V
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
-
Q
--
L
G
Y
K
I
G
V
G
G
T
I
T
Y
-
P
-
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
L
N
G
F
-------------
Q
---------------------------
G
----
Q
----
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
P
8
PsiBlast_PDB
77.78
30%
-99
- C2 -
1ZZM
4
YJJV_ECOLI
A:
[7-258]
---
D
T
H
C
H
F
D
F
P
P
F
----------
S
----------
G
---
D
E
E
A
S
L
Q
R
A
A
Q
A
G
V
G
K
I
I
V
P
A
T
E
A
E
N
F
A
R
V
L
A
L
A
E
----
N
Y
----
Q
----
P
----
L
Y
A
A
L
G
L
H
P
G
MLE
K
H
S
D
V
S
----
L
-------------------
E
Q
L
Q
Q
A
L
E
R
R
P
-----------
A
K
V
V
A
V
G
E
I
G
L
D
L
F
----
G
D
D
-
P
----
Q
F
E
R
Q
Q
W
L
L
D
E
Q
L
K
L
A
K
R
Y
----
D
L
P
V
I
L
H
S
R
R
T
H
D
K
L
A
M
-
H
L
K
R
H
--------------------------
D
L
P
R
-
T
G
--
V
V
H
G
F
S
G
S
L
Q
Q
A
E
R
F
V
-
Q
--
L
G
Y
K
I
G
V
G
G
T
I
T
Y
-
P
-
R
-
A
S
K
T
R
D
V
I
A
K
L
P
L
A
S
L
L
L
E
T
D
A
P
D
-----
M
P
L
N
G
F
-------------
Q
---------------------------
G
----
Q
----
P
N
R
P
E
Q
A
A
R
V
F
A
V
L
C
E
L
R
R
E
P
A
D
E
I
A
Q
A
L
L
N
N
T
Y
T
L
F
N
V
-
29
HHSearch
76.66
29%
-87
- C2 -
3IPW
1
?
A:
[27-323]
Q
F
I
D
I
G
A
N
L
T
D
D
N
Y
FGNYHGKHYH
E
----------
E
---
D
I
D
V
V
L
Q
R
A
E
R
N
G
L
S
H
I
I
I
T
S
G
C
L
N
D
F
K
K
A
I
E
I
I
N
----
K
Y
----
Q
N---
L
TN
I
K
L
V
T
T
I
G
V
H
P
T
---
R
T
N
E
L
K
Q---
E
-------------------
G
Y
L
D
E
L
L
L
L
C
E
K
N
------
I
--
D
K
V
V
A
I
G
E
I
G
L
D
Y
E
----
R
L
Q
F
S
----
D
K
E
T
Q
L
S
G
Y
R
T
L
S
I
L
H
Q
K
Y
P---
Y
L
P
F
F
F
H
C
R
K
S
W
S
D
L
C
Q
-
L
N
K
E
L
--------------------------
G
Y
-
N
-
G
C
K
G
V
V
H
C
F
D
G
T
E
E
E
M
N
Q
I
L
-
N
--
E
G
W
D
I
G
V
T
G
N
S
L
Q
-
S
----
I
E
L
L
N
V
M
K
Q
I
P
I
E
R
L
H
I
E
T
D
C
P
Y
-----
C
G
I
K
K
T
S------------
A
GFKYLKEKDFGVKVEKYQRNKYV----
Q
----
R
----
R
N
E
P
S
N
I
I
D
I
A
I
I
M
S
S
I
K
H
I
S
L
F
E
F
V
N
K
V
Y
S
N
S
M
N
M
Y
F
P
T
32
HHSearch
76.09
27%
-98
- C2 -
2XIO
3
TATD1_HUMAN
A:
[2-292]
K
F
I
D
I
G
I
N
L
T
D
P
M
F
----------
R
GIYRGVQKHQ
D
---
D
L
Q
D
V
I
G
R
A
V
E
I
G
V
K
K
F
M
I
T
G
G
N
L
Q
D
S
K
D
A
L
H
L
A
Q
----
T
N
----
G
----
M
----
F
F
S
T
V
G
C
H
P
T
---
R
C
G
E
F
E
K
N
N
P
D
-------------------
L
Y
L
K
E
L
L
N
L
A
E
N
N
------
K
--
G
K
V
V
A
I
G
E
C
G
L
D
F
D
----
R
L
Q
F
C
----
P
K
D
T
Q
L
K
Y
F
E
K
Q
F
E
L
S
E
Q
T
----
K
L
P
M
F
L
H
C
R
N
S
H
A
E
F
L
D
-
I
T
K
R
N
--------------------------
R
D
-
R
-
C
V
G
G
V
V
H
S
F
D
G
T
K
E
A
A
A
A
L
I
-
D
--
L
D
L
Y
I
G
F
N
G
C
S
L
K
-
T
----
E
A
N
L
E
V
L
K
S
I
P
S
E
K
L
M
I
E
T
D
A
P
W
-----
C
G
V
K
S
T
HAGSKYIRTAFPT
K
KKWES----------------------
G
HCLK
D
----
R
N
E
P
C
H
I
I
Q
I
L
E
I
M
S
A
V
R
D
E
D
P
L
E
L
A
N
T
L
Y
N
N
T
I
K
V
F
F
P
-
9
PsiBlast_PDB
75.55
28%
-103
- C2 -
3RCM
3
?
A:
[3-248]
-
L
I
D
I
G
V
N
L
T
N
S
S
F
----------
H
----------
D
---
Q
Q
A
A
I
V
E
R
A
L
E
A
G
V
T
Q
M
L
L
T
G
T
S
L
A
V
S
E
Q
A
L
E
L
C
Q
----
Q
L
----
D
ASGA
H
----
L
F
A
T
A
G
V
H
P
H
---
D
A
K
A
W
D
----
T
-------------------
D
S
E
R
Q
L
R
L
L
L
S
--------
E
--
P
R
V
R
A
V
G
E
C
G
L
D
F
N
----
R
D
F
-
S
----
P
R
P
L
Q
E
K
A
L
E
A
Q
L
T
L
A
A
Q
L
----
R
L
P
V
F
L
H
E
R
D
A
S
E
R
L
L
A
-
I
L
K
D
Y
--------------------------
R
D
H
L
-
T
G
-
A
V
V
H
C
F
T
G
E
R
E
A
L
F
A
Y
L
-
D
--
L
D
L
H
I
G
I
T
G
W
I
C
D
E
R
-
R
-
G
T
H
L
H
P
L
V
G
N
I
P
E
G
R
L
M
L
E
S
D
A
P
Y
-----
L
L
P
R
S
L
-------------
R
---------------------------
P
----
K
PKSG
R
N
E
P
A
F
L
P
E
V
L
R
E
V
A
-------------------------