@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00018_GRB2_M: (2014-08-10 )
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Atome Classification :
(57 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEA
I
A
KYDFKATADDELSFKR
G
D
I
L
K
V
L
N
E
E
CDQN
W
Y
K
A
ELNGKDGFIPKN
Y
I
EMKPHP
W
F
FGKIP
R
A
K
A
E
E
M
L
S
KQRHD
G
A
F
L
I
RESESAPG
D
F
S
L
S
V
K
FGN
D
V
Q
H
F
K
V
L
R
DGAG
K
Y
F
L
W
V
V
K
FN
S
L
N
E
L
V
D
Y
H
RSTSVSRN
Q
Q
I
F
L
R
D
I
E
QMPQQ
P
T
Y
V
Q
A
L
FDFDPQEDGELGFRRG
D
F
I
H
V
MDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
13
PsiBlast_PDB
61.30
99%
-133
- C4 -
3S8N
3
GRB2_HUMAN
A:
[2-102]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
7
PsiBlast_PDB
61.05
99%
-140
- C4 -
3IN7
1
GRB2_HUMAN
A:
[3-101]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
24
PsiBlast_CBE
61.03
99%
-141
- C4 -
3IN7
1
GRB2_HUMAN
C:
[3-102]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
12
PsiBlast_PDB
61.00
99%
-130
- C4 -
3S8L
2
GRB2_HUMAN
A:
[2-102]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
31
PsiBlast_CBE
60.90
99%
-133
- C4 -
3N84
2
GRB2_HUMAN
B:
[3-108]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
Q
Q
P
T
----------------------------------------------------------
20
PsiBlast_PDB
60.82
99%
-138
- C4 -
3C7I
2
GRB2_HUMAN
A:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
4
PsiBlast_PDB
60.76
99%
-130
- C4 -
3OVE
1
GRB2_HUMAN
A:
[2-102]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
29
PsiBlast_CBE
60.67
99%
-142
- C4 -
3N84
3
GRB2_HUMAN
D:
[3-103]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
8
PsiBlast_PDB
60.61
99%
-135
- C4 -
3IN8
2
GRB2_HUMAN
A:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
30
PsiBlast_CBE
60.48
99%
-132
- C4 -
3N84
2
GRB2_HUMAN
C:
[4-112]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
Q
Q
P
T
Y
V
Q
A
------------------------------------------------------
28
PsiBlast_CBE
60.48
99%
-138
- C4 -
3N84
3
GRB2_HUMAN
E:
[2-102]
----------------------------------------------------
I
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
10
PsiBlast_PDB
60.47
99%
-136
- C4 -
3N8M
2
GRB2_HUMAN
A:
[3-101]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
25
PsiBlast_CBE
60.38
99%
-143
- C4 -
3IMJ
1
GRB2_HUMAN
B:
[4-103]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
15
PsiBlast_PDB
60.34
99%
-130
- C4 -
3N84
3
GRB2_HUMAN
A:
[4-112]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
Q
Q
P
T
Y
V
Q
A
------------------------------------------------------
6
PsiBlast_PDB
60.25
99%
-140
- C4 -
3IMJ
1
GRB2_HUMAN
A:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
14
PsiBlast_PDB
60.17
99%
-128
- C4 -
3S8O
1
GRB2_HUMAN
A:
[2-102]
-----------------------------------------------------
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
---------------------------------------------------------------
46
PsiBlast_CBE
60.04
100%
-132
- C4 -
1TZE
1
GRB2_HUMAN
E:
[1-98]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
27
PsiBlast_CBE
60.02
99%
-135
- C4 -
3N84
4
GRB2_HUMAN
F:
[2-102]
----------------------------------------------------
I
E
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
26
PsiBlast_CBE
60.02
99%
-131
- C4 -
3IMD
1
GRB2_HUMAN
B:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
41
PsiBlast_CBE
59.95
100%
-139
- C4 -
3MXY
1
GRB2_HUMAN
A:
[4-101]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
2
PsiBlast_PDB
59.94
99%
-138
- C4 -
1BM2
1
GRB2_HUMAN
A:
[9-106]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
19
PsiBlast_PDB
59.91
99%
-137
- C4 -
2HUW
1
GRB2_HUMAN
A:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
1
PsiBlast_PDB
59.89
99%
-135
- C4 -
1BMB
1
GRB2_HUMAN
A:
[11-108]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
47
PsiBlast_CBE
59.82
100%
-136
- C4 -
1ZFP
1
GRB2_HUMAN
E:
[1-98]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
9
PsiBlast_PDB
59.54
99%
-129
- C4 -
3KFJ
1
GRB2_HUMAN
A:
[4-103]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
44
PsiBlast_CBE
59.52
100%
-135
- C4 -
3N7Y
1
GRB2_HUMAN
B:
[1-98]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
43
PsiBlast_CBE
59.48
100%
-134
- C4 -
3N7Y
1
GRB2_HUMAN
C:
[1-98]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
32
PsiBlast_CBE
59.32
99%
-138
- C4 -
2HUW
1
GRB2_HUMAN
B:
[4-101]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
----------------------------------------------------------------
5
PsiBlast_PDB
59.29
99%
-131
- C4 -
3IMD
1
GRB2_HUMAN
A:
[3-103]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
--------------------------------------------------------------
42
PsiBlast_CBE
58.64
100%
-133
- C4 -
3MXC
1
GRB2_HUMAN
A:
[4-101]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
34
PsiBlast_CBE
58.26
99%
-118
- C4 -
1QG1
1
GRB2_HUMAN
E:
[3-104]
---------------------------------------------------------
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
V
P
Q
Q
P
T
----------------------------------------------------------
45
PsiBlast_CBE
57.98
100%
-136
- C4 -
3N7Y
1
GRB2_HUMAN
A:
[1-98]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
87
HHSearch
57.86
98%
-134
- C4 -
3WA4
2
?
A:
[3-98]
--------------------------------------------------------
P
E
F
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
57
PsiBlast_CBE
57.57
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
C:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
50
PsiBlast_CBE
57.53
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
J:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
58
PsiBlast_CBE
57.12
100%
-133
- C4 -
1CJ1
1
GRB2_HUMAN
B:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
49
PsiBlast_CBE
57.12
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
K:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
55
PsiBlast_CBE
57.09
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
E:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
52
PsiBlast_CBE
57.09
100%
-133
- C4 -
1CJ1
1
GRB2_HUMAN
H:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
54
PsiBlast_CBE
56.85
100%
-133
- C4 -
1CJ1
1
GRB2_HUMAN
F:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
56
PsiBlast_CBE
56.81
100%
-133
- C4 -
1CJ1
1
GRB2_HUMAN
D:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
59
PsiBlast_CBE
56.73
100%
-133
- C4 -
1CJ1
1
GRB2_HUMAN
A:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
51
PsiBlast_CBE
56.69
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
I:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
53
PsiBlast_CBE
56.66
100%
-134
- C4 -
1CJ1
1
GRB2_HUMAN
G:
[1-96]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
36
PsiBlast_CBE
51.15
100%
-119
- C4 -
2AOB
6
GRB2_HUMAN
C:
[2-97]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
------------------------------------------------------------------
23
PsiBlast_CBE
50.21
99%
-120
- C4 -
1FYR
2
GRB2_HUMAN
B:
[8-105]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
38
PsiBlast_CBE
49.97
100%
-120
- C4 -
2AOB
6
GRB2_HUMAN
A:
[2-97]
-------------------------------------------------------
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
------------------------------------------------------------------
22
PsiBlast_CBE
49.51
99%
-111
- C4 -
1FYR
2
GRB2_HUMAN
C:
[8-105]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
3
PsiBlast_PDB
49.33
99%
-115
- C4 -
1FYR
2
GRB2_HUMAN
A:
[11-105]
---------------------------------------------------------
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
17
PsiBlast_PDB
49.11
99%
-113
- C4 -
2H46
1
GRB2_HUMAN
E:
[3-100]
------------------------------------------------------
M
K
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
18
PsiBlast_PDB
48.81
99%
-110
- C4 -
2H5K
1
GRB2_HUMAN
A:
[5-100]
--------------------------------------------------------
P
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
84
HHSearch
48.77
52%
-116
* C4 *
1R1P
1
GRAP2_MOUSE
A:
[6-100]
------------------------------------------------------
I
E
F
P
E
W
F
H
E
G
L
S
R
H
Q
A
E
N
L
L
-
M
G
K
D
I
G
F
F
I
I
R
A
S
Q
S
S
P
G
D
F
S
I
S
V
R
H
E
D
D
V
Q
H
F
K
V
M
R
D
T
K
G
N
Y
F
L
W
T
E
K
F
P
S
L
N
K
L
V
D
Y
Y
R
T
T
S
I
S
K
Q
K
Q
V
F
L
R
D
-------------------------------------------------------------------
40
PsiBlast_CBE
48.55
100%
-117
- C4 -
2AOA
4
GRB2_HUMAN
A:
[4-96]
---------------------------------------------------------
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
-------------------------------------------------------------------
21
PsiBlast_CBE
46.64
99%
-105
- C4 -
1FYR
2
GRB2_HUMAN
D:
[11-105]
---------------------------------------------------------
H
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
E
-----------------------------------------------------------------
37
PsiBlast_CBE
45.93
100%
-115
- C4 -
2AOB
5
GRB2_HUMAN
B:
[5-97]
----------------------------------------------------------
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
------------------------------------------------------------------
35
PsiBlast_CBE
45.03
100%
-108
- C4 -
2AOB
5
GRB2_HUMAN
D:
[5-97]
----------------------------------------------------------
P
W
F
F
G
K
I
P
R
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
S
E
S
A
P
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
D
I
------------------------------------------------------------------
39
PsiBlast_CBE
38.95
100%
-107
- C4 -
2AOA
3
GRB2_HUMAN
B:
[14-95]
-------------------------------------------------------------------
A
K
A
E
E
M
L
S
K
Q
R
H
D
G
A
F
L
I
R
E
-----
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
T
S
V
S
R
N
Q
Q
I
F
L
R
--------------------------------------------------------------------