@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MRGX4_HUMAN: (2016-01-11 )
MDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTGNAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVMTFPYFTGLSMLSAISTERCLSVLWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRFCDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGILGALIYRMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRLGP
Atome Classification :
(20 SA)
......-----.-..10........20...---------.-----....30.-.......40........50..-.-.-...-.-.60........70......----..-80........----90---.----..-----......100.......110.......120.......-130.---......140.....------..150-----...-......-----160------.....--..-----.170-----.-----....--------------.-.-..180....------...190..-------....---------------------------------.---200..----------------...-------------------------------------------------------------------------------------------------------------------------------------------------------------------..-------210.........220.-......230--........240.-.--------.-------.-------.-..250.......260.......270.....-..280..-.....290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDPTVP-----V-FGTKLTPINGREETPCY---------N-----Q
T
L
S
F
T
V
-
L
T
C
I
I
S
L
VGLTG
N
A
V
V
L
W
-
L
L
-
G
-
Y
-
R
MR-R-
N
A
V
S
I
Y
I
L
NLA
A
A
D
F
L
F
L
S
----
F
Q
-
I
I
R
L
P
L
R
L
I
N
----
I
----
S
----
H
L
-----
I
R
K
I
L
V
S
V
M
T
F
P
Y
F
T
G
L
S
M
L
S
A
I
S
T
E
R
C
L
S
V
L
W
P
I
W
-
Y
R
CR---RP
T
H
L
S
A
V
V
C
V
L
L
W
------
G
L
S
-------
L
L
F
-
S
M
L
E
W
R
-----
F
-
C
------
D
F
L
FS--GA-----DS-------S-----WCET--------------S-D-F
I
P
V
A
W
L
I
F
------
L
C
V
V
L
C
V
S
-------
S
L
V
L
---------------------------------
L
---
V
R
I
L
C----------------GSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------KM-------
P
--
L
T
R
L
Y
V
T
I
L
L
T
V
L
-
V
F
L
LCGL
P
---
F
G
I
L
G
A
L
I
Y
R
M
H-L--------
N
-------
L
-------
E
-
V
L
Y
C
H
V
Y
L
V
C
M
S
L
S
S
LNSSAN
P
I
I
Y
F
FV
G
S
-
F
R
Q
RQN
R
-
Q
N
L
K
L
V
L
Q
R
A
LQDKPEVDKGEGQL
P
E
E
S
L
ELSGSRLGP
43
Fugue
82.13
28%
-150
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------
S
-
F
K
C
A
L
T
K
T
G
-----------------
F
-----
Q
F
Y
Y
L
P
A
-
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
F
-
V
-
F
-
H
M
K
-
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
----
T
L
-
P
A
L
I
F
Y
Y
F
N
K
----
T
----
D
WIFG
D
A
-----
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
--
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
------
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
KNKTI
T
-
C
YDTTSD
E
Y
L
R
S
--
Y
F
-----
I
Y
-------
S
-----
M
C
T
T
--------------
V
-
A
M
F
C
V
P
L
V
L
I
L
------
G
C
Y
G
L
I
V
R
-------
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKD
I
---
V
C
P
L
C
----------------
G
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
Q
F
E
E
V
EE
P
--
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
---
F
H
V
M
K
T
M
N
L
R
A
R
-
L
DFQTPAM
C
A
-------
F
-------
N
-
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
-
T
F
R
R
R
-----------------------------------------
12
PsiBlast_PDB
77.45
24%
-144
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[125-407]
----------------------------------------------
A
I
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
-
Y
-
T
K
M
-
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
-
F
Q
-
S
A
K
Y
L
M
E
T
W
P
----
F
----
G
----
E
L
-----
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
------
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
DGAV-
V
-
C
------
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
-----
W
-
D
T
--------------
V
-
T
-
K
I
C
V
F
L
F
A
F
------
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
---------------------------------
S
---
V
R
L
L
S
----------------
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-------
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
-
A
F
V
V
C
W
A
P
---
I
H
I
F
V
I
V
W
T
L
V
D
-
I
--------
D
-------
R
R------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
R
K
P
C
G
------------------------------
15
PsiBlast_PDB
76.15
24%
-145
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[122-404]
----------------------------------------------
A
I
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
-
Y
-
T
K
M
-
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
-
F
Q
-
S
A
K
Y
L
M
E
T
W
P
----
F
----
G
----
E
L
-----
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
------
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
DG
A
V
-
V
-
C
------
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
-----
W
-
D
T
--------------
V
-
T
-
K
I
C
V
F
L
F
A
F
------
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
---------------------------------
S
---
V
R
L
L
S
----------------
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-------
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
-
A
F
V
V
C
W
A
P
---
I
H
I
F
V
I
V
W
T
L
V
D
-
I
--------
D
-------
R
R------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
-----------------------------------
14
PsiBlast_PDB
76.07
24%
-136
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[122-404]
----------------------------------------------
A
I
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
-
Y
-
T
K
M
-
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
-
F
Q
-
S
A
K
Y
L
M
E
T
W
P
----
F
----
G
----
E
L
-----
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
------
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
R
P
R
DG
A
V
-
V
-
C
------
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
-----
W
-
D
T
--------------
V
-
T
-
K
I
C
V
F
L
F
A
F
------
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
-------------------------------------------------------------
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-------
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
-
A
F
V
V
C
W
A
P
---
I
H
I
F
V
I
V
W
T
L
V
D
-
I
--------
D
-------
R
R------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
-----------------------------------
1
PsiBlast_PDB
74.66
26%
-147
- C3 -
5C1M
7
?
A:
[8-294]
-----------------------
Q
T
G
S
P
S
M
---------
V
-----
T
A
I
T
I
M
A
-
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
-
V
I
V
R
-
Y
-
T
K
M
-
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
-
F
Q
-
S
V
N
Y
L
M
G
T
W
P
----
F
----
G
----
N
I
-----
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
-
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
-------
V
M
F
M
A
T
T
K
Y
R
QGSI-
D
-
C
------
T
L
T
F
S
--
H
P
-----
T
W
-------
Y
-----
W
-----------------
E
-
N
-
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
-------
L
M
I
L
---------------------------------
R
L
K
S
V
R
M
L
S
----------------
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
-------
D
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
-
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
P
E
-
T
--------
T
-------
F
-------
Q
-
T
V
S
W
H
---
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
----------------------------------------
5
PsiBlast_PDB
74.11
23%
-172
- C3 -
4XT1
15
US28_HCMVA
A:
[25-309]
----------------------
D
E
D
A
T
P
C
V
F
T
D
V
L
----
N
-----
Q
S
K
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
-
T
-
W
-
R
R
R
I
Q
-
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
---------
V
C
T
L
P
L
W
M
Q
Y
----
L
L
D----------------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
-
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
------
I
F
A
-------
V
I
I
-
A
I
P
H
-----------------
F
M
V
V
--
T
K
-----
K
D
-------
N
-----
Q
C
M
T
--------------
D
Y
D
-
Y
L
E
V
S
Y
P
I
I
------
L
N
V
E
L
M
L
G
-------
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
----------------------
I
---
S
R
I
V
A
----------------
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-------
H
--
K
G
R
I
V
R
V
L
I
A
V
V
L
-
V
F
I
I
F
W
L
P
---
Y
H
-
L
T
L
F
V
D
T
L
K
-
L
L
KW
I
S
S
S
C
E
-------
F
-------
E
-
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
-
L
L
A
E
F
R
--------------------------------
44
Fugue
73.88
17%
-126
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
PNFYV
P
-
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
---------
Y
LAE
P
W
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
-
V
Q
H
-
K
K
L
-
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
----
F
----
G
----
P
T
-----
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
------
A
L
A
-------
C
A
A
-
P
P
L
-
V
G
-----
W
-
S
------
R
Y
I
P
E
--
G
M
-----
Q
C
-------
S
C
G
I
DY
Y
T
P
H
--------------
E
-
E
-
T
N
N
E
S
F
V
I
Y
------
M
F
V
V
H
F
I
I
-------
P
L
I
V
---------------------------------
I
---
F
F
C
Y
G
Q
L
VFTVKEAAAS----
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-------
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
-
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--------
D
-------
F
-------
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
---
Y
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
-
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------
6
PsiBlast_PDB
72.56
23%
-167
- C3 -
4XT3
2
US28_HCMVA
A:
[26-309]
-----------------------
E
D
A
T
P
C
V
F
T
D
V
L
----
N
-----
Q
S
K
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
-
T
-
W
-
R
R
R
I
Q
-
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
---------
V
C
T
L
P
L
W
M
Q
Y
----
L
L
D--
H
------------
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
-
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
------
I
F
A
-------
V
I
I
-
A
I
P
H
-----------------
F
M
V
V
--
T
K
-----
K
D
-------
N
-----
Q
C
M
T
--------------
D
Y
D
-
Y
L
E
V
S
Y
P
I
I
------
L
N
V
E
L
M
L
G
-------
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
----------------------
I
---
S
R
I
V
A
----------------
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-------
H
--
K
G
R
I
V
R
V
L
I
A
V
V
L
-
V
F
I
I
F
W
L
P
---
Y
H
-
L
T
L
F
V
D
T
L
K
-
L
L
KW
I
S
S
S
C
E
-------
F
-------
E
-
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
-
L
L
A
E
----------------------------------
33
HHSearch
70.47
18%
-144
- C3 -
2KS9
1
NK1R_HUMAN
A:
[32-323]
----------------------------------------------
I
V
L
W
A
A
-
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-
I
I
-
L
-
A
H
K
R
M
-
R
-
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
----
F
N
-
T
V
V
N
F
T
Y
A
V
H
----
N
EWYY
G
----
L
F
-----
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
-
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
------
V
L
A
-------
L
L
L
-
A
F
P
Q
G
Y
-----
Y
-
S
------
T
T
E
T
M
--
P
------
S
R
-------
V
-----
V
C
M
I
EWPEHPNKIY
E
K
V
Y
H
-
I
-
C
V
T
V
L
I
Y
F
L
------
P
L
L
V
I
G
Y
A
-------
Y
T
V
V
---------------------------------
G
---
I
T
L
W
A
----------------
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
-------
A
--
K
R
K
V
V
K
M
M
I
V
V
V
C
-
T
F
A
I
C
W
L
P
---
F
H
I
F
F
L
L
P
Y
I
N
P
-
D
--------
L
-------
Y
-------
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
F
--
R
---
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
47
Fugue
69.86
16%
-123
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
-----
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
APQYYLAE
P
W
-----
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
-
V
Q
H
-
K
K
L
-
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
V
----
F
----
G
----
P
T
-----
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
------
A
L
A
-------
C
A
A
-
P
P
L
-
V
G
-----
W
-
S
------
R
Y
I
P
E
--
G
M
-----
Q
C
-------
S
C
G
I
DY
Y
T
P
H
--------------
E
-
E
-
T
N
N
E
S
F
V
I
Y
------
M
F
V
V
H
F
I
I
-------
P
L
I
V
---------------------------------
I
---
F
F
C
Y
G
Q
L
VFTVKEAAAQQQES
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-------
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
-
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--------
D
-------
F
-------
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
---
Y
N
P
V
I
Y
I
M
M
--------
N
K
-
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-
28
HHSearch
69.34
15%
-133
- C3 -
2Z73
5
OPSD_TODPA
A:
[29-334]
---------------------------
V
P
D
---------
A
-----
V
Y
Y
S
L
G
I
-
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-
L
F
-
T
-
K
T
K
S
L
-
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
----
V
N
G
F
P
L
M
T
I
S
C
F
L
----
K
KWIF
G
----
F
A
-----
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
-
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
------
L
W
S
-------
V
L
W
-
A
I
G
P
I
F
-----
G
-
W
------
G
A
Y
T
L
--
E
G
-----
V
L
-------
C
-----
N
C
S
F
DYISRD
S
T
T
R
S
N
--
I
-
L
-
C
M
F
I
L
G
F
F
G
------
P
I
L
I
I
F
F
C
-------
Y
F
N
I
---------------------------------
V
---
M
S
V
S
N
----------------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
N
-------
A
--
E
M
R
L
A
K
I
S
I
V
I
V
S
-
Q
F
L
L
S
W
S
P
---
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
--------
E
-----------------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
-
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------
34
HHSearch
69.09
16%
-141
- C3 -
3EML
13
ENLYS_BPT4
A:
[20-470]
---------------------------------------------
G
S
S
V
Y
I
T
-
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
-
W
-
L
N
S
N
L
-
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
----
L
A
-
I
P
F
A
I
T
I
S
T
G
----
F
CA--
A
----
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
-
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
------
V
L
S
-------
F
A
I
-
G
L
T
P
M
L
-----
G
-
W
------
N
N
C
G
Q
----------
S
QGCGEGQ
V
-----
A
C
L
F
EDVVP
M
N
Y
M
-----
V
-
Y
-
F
N
F
F
A
C
V
L
V
------
P
L
L
L
M
L
G
V
-------
Y
L
R
I
---------------------------------
F
---
L
A
A
R
R
----------------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
Q
-------
K
--
E
V
H
A
A
K
S
L
A
I
I
V
G
-
L
F
A
L
C
W
L
P
---
L
H
I
I
N
C
F
T
F
F
C
P
-
D
--------
C
-------
S
---------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
--
R
---
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------
37
HHSearch
67.83
24%
-140
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
---------------------------------------
L
-----
N
K
Y
V
V
I
I
-
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-
V
I
-
L
-
Y
S
R
V
G
-
R
-
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
----
T
L
-
P
I
W
A
A
S
K
V
N
G
WI--
F
----
G
----
T
F
-----
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
-
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
------
G
L
S
-------
M
N
L
-
S
L
P
F
F
L
-----
F
-
R
------
Q
A
Y
H
P
--
N
N
-----
S
S
-------
P
-----
V
C
Y
E
VLGNDTAKWRMVL-
R
-
I
-
L
P
H
T
F
G
F
I
V
------
P
L
F
V
M
L
F
C
-------
Y
G
F
T
---------------------------------
L
---
R
T
L
F
K
----------------
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
-------
Q
--
K
H
R
A
M
R
V
I
F
A
V
V
L
-
I
F
L
L
C
W
L
P
---
Y
N
L
V
L
L
A
D
T
L
M
R
-
T
--------
Q
-------
V
IQE
S
C
E
R
R
-
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
-
N
F
--
R
---
H
G
F
L
K
I
L
A
M
H
G
---------------------------
26
HHSearch
67.27
20%
-136
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-495]
---------------------------
N
A
N
---------
F
-----
N
K
I
F
L
P
T
-
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
-
V
M
-
G
-
Y
Q
K
K
L
-
R
-
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
----
T
--
L
P
F
W
A
V
D
A
V
A
----
N
WYF-
G
----
N
F
-----
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
-
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
------
I
P
A
-------
L
L
L
-
T
I
P
D
F
I
-----
F
-
A
------
N
V
S
E
A
--
D
------
D
R
-------
Y
-----
I
C
D
R
F
Y
PN
D
L
W
V
V
V
F
---
Q
-
F
-
Q
H
I
M
V
G
L
I
L
------
P
G
I
V
I
L
S
C
-------
Y
C
I
I
---------------------------------
I
---
S
K
L
S
H
----------------
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-------
Q
--
K
R
K
A
L
K
T
T
V
I
L
I
L
-
A
F
F
A
C
W
L
P
---
Y
Y
I
G
I
S
I
D
S
F
I
L
-
L
--------
E
I
I
K
Q
G
C
E
F
-------
E
-
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
-
K
F
--
K
---
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------
25
HHSearch
66.14
17%
-142
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------------
V
V
F
I
V
L
-
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-
S
I
-
K
-
V
N
R
H
L
-
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
----
F
S
-
M
N
L
Y
T
L
Y
T
V
I
GYWP
L
----
G
----
P
V
-----
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
-
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
------
V
L
S
-------
F
I
L
-
W
A
P
A
I
L
-----
F
-
W
------
Q
F
I
V
G
VR
T
V
-----
E
D
-------
G
-----
E
C
Y
I
QFFSN
A
A
V
------
T
-
F
-
G
T
A
I
A
A
F
Y
L
------
P
V
I
I
M
T
V
L
-------
Y
W
H
I
---------------------------------
S
---
R
A
S
K
S
----------------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
S
-------
R
--
E
K
K
V
T
R
T
I
L
A
I
L
L
-
A
F
I
I
T
W
A
P
---
Y
N
V
M
V
L
I
N
T
F
C
A
-
P
--------------------------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
--
K
---
K
T
F
K
H
L
L
M
------------------------------
36
HHSearch
65.90
17%
-145
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------
Y
A
L
-
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
-
A
V
-
L
-
K
E
R
A
L
-
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
----
L
V
-
M
P
W
V
V
Y
L
E
V
T
----
G
----
G
----
V
W
NFS
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
-
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
------
V
L
A
-------
F
A
V
-
S
C
P
L
L
F
-----
G
-
F
------
N
T
T
G
----------
D
P
-------
T
-----
V
C
S
I
SN
P
D
F
---------
V
-
I
-
Y
S
S
V
V
S
F
Y
L
------
P
F
G
V
T
V
L
V
-------
Y
A
R
I
---------------------------------
Y
---
V
V
L
K
Q
----------------
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGV
P
L
-------
R
--
E
K
K
A
T
Q
M
V
A
I
V
L
G
-
A
F
I
V
C
W
L
P
---
F
F
L
T
H
V
L
N
T
H
C
Q
-
T
--------
C
-----------------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
-
E
F
--
R
---
K
A
F
L
K
I
L
S
C
-----------------------------
29
HHSearch
65.66
16%
-147
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------------
V
V
G
M
G
I
-
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-
A
I
-
A
-
K
F
E
R
L
-
Q
-
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
----
A
V
-
V
P
F
G
A
A
H
I
L
M
---------
K
----
M
W
TFG
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
------
I
V
S
-------
G
L
T
-
S
F
L
P
I
Q
-----
M
H
W
------
Y
R
A
T
H
--
Q
E
A
I
N
C
Y
A
E
-------
E
-----
T
C
C
D
FFTN
Q
A
Y
-------
A
-
I
-
A
S
S
I
V
S
F
Y
V
------
P
L
V
I
M
V
F
V
-------
Y
S
R
V
---------------------------------
F
---
Q
E
A
K
R
----------------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
L
-------
K
--
E
H
K
A
L
K
T
L
G
I
I
M
G
-
T
F
T
L
C
W
L
P
---
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
--------------------------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
-
D
F
--
R
---
I
A
F
Q
E
L
L
C
L
-----------------------------
30
HHSearch
64.25
18%
-142
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------------
P
L
V
V
-
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
V
-
R
-
S
E
R
K
L
-
H
-
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
----
V
V
-
M
P
M
N
I
L
Y
L
L
M
---------
S
----
K
W
SLG
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
-
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
------
F
L
S
-------
F
L
W
-
V
I
P
I
L
G
-----
W
-
N
------
H
-------
R
-----
R
E
-------
D
-----
K
C
E
T
DFYDV
T
W
F
------
K
-
V
-
M
T
A
I
I
N
F
Y
L
------
P
T
L
L
M
L
W
F
-------
Y
A
K
I
---------------------------------
Y
---
K
A
V
R
Q
----------------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
N
-------
R
--
E
R
K
A
A
K
Q
L
G
F
I
M
A
-
A
F
I
L
C
W
I
P
---
Y
F
I
F
F
M
V
I
A
F
C
K
-
N
--------------------------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
-
N
F
--
K
---
K
T
F
K
R
I
L
H
I
-----------------------------
35
HHSearch
63.34
14%
-135
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-326]
---------------------------------------------
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
-
V
-
Q
H
K
K
L
-
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
T
T
T
L
Y
T
S
L
H
---------
G
----
Y
F
VFG
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
------
V
M
A
-------
L
A
C
-
A
A
P
P
L
V
-----
G
-
W
------
S
R
Y
I
P
--
E
G
-----
M
Q
-------
C
-----
S
C
G
I
DYYTPHEETN
N
E
S
F
V
-
I
-
Y
M
F
V
V
H
F
I
I
------
P
L
I
V
I
F
F
C
-------
Y
G
Q
L
---------------------------------
V
---
F
T
V
K
E
----------------
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-------
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
-
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
I
F
T
H
Q
-
G
--------
S
-----------------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
--
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----
31
HHSearch
58.90
18%
-136
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[58-495]
---------------------------
D
K
E
---------
N
-----
S
I
K
L
T
S
V
-
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
-
T
I
-
W
-
K
T
K
K
F
-
H
-
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
----
A
Y
-
T
A
N
L
L
L
S
G
A
T
----
T
YKL-
T
----
P
A
-----
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
------------
N
N
F
R
L
F
L
L
I
S
A
C
W
------
V
I
S
-------
L
I
L
-
G
G
L
P
I
M
-----
G
-
W
------
N
C
I
S
----------
A
L
-------
S
-----
S
C
S
T
VLPLYH
K
H
------
Y
-
I
-
L
F
C
T
T
V
F
T
L
------
L
L
L
S
I
V
I
L
-------
Y
C
R
I
---------------------------------
Y
---
S
L
V
R
T
----------------
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
--
S
S
-------
E
--
N
V
A
L
L
K
T
V
I
I
V
L
S
-
V
F
I
A
C
W
A
P
---
L
F
I
L
L
L
L
D
V
G
C
K
-
V
--------
K
-------
T
---------
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
-
E
M
--
R
---
R
A
F
I
R
I
M
G
R
P
L
---------------------------