@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0462: (2015-12-01 )
MIGSPVILAPMSGVTDYPFRSIVKKLGASLLVSEMIASRAMIMQTRQSMQKAKVDELTAVQLAGCEPDIMAEAAKLNEDMGAKIIDINFGCPVKKVVNGYAGSALMRNEKKAAEIIEAVVKAVNVPVTVKIRTGWNNENRNAPRLAKIAEDLGAKMITVHGRTRAQLYNGQADWKFIRNVKEQVKIPVIVNGDIKSLNDIQNALKESRADGVMIGRGAYGRPWLINQAINFLSGSEVSEPTASEKLSIILEHYDNILEYYGNDAGIKIARKHIGWYSSGFKNSSEFRVRVNNMTDSMEVKENIVSFFSQV
Atome Classification :
(20 SA)
.........10...--------.--------.---------....20...--..-.-..-30....-.....40--.---------------------.--.----------------------.-----------.---------.-.-.-50--..------.....-.-.-----------60....------------------------.-----------------------.----------------------..70........-80........90--------.---------........100.......110.......120.--......130....----.----.--.--140.......150.......160..----------------------.----------------.--..----.-170.----.---------.......180..-.....190.......200.......210.......220........230.......240.-......250.......260.--......-270.........280.......290........300-....-...310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIGS
P
V
I
L
AP-MSG--------V--------T---------DY
P
F
R
S
I
V
K
--
K
L
-
G
-
A
S
-
L
-
L
V
S
E
-
M
I
A
S
R
A
M
--
I
---------------------
M
--
Q
----------------------
T
-----------
R
---------
Q
-
S
-
M
-
Q
---
K
A------KVD
E
L
-
T
-
A
-----------
V
Q
LAGC------------------------
E
-----------------------
P
----------------------
D
I
M
A
E
A
A
KLNED-MG
A
K
I
I
D
I
NFG---------C---------
P
V
K
K
V
V
N
GYAG
S
A
L
MR
N
E
K
K
A
A
E
I
I
E
A
V
V
K
AV--NV
P
V
T
V
K
I
RTGWN----N----E--N--RNA
P
R
L
A
K
I
A
E
D
LGA
K
M
I
T
VHGR
T
R
----------------------
A
----------------
Q
--
L
Y----N-G--Q----
A
---------
D
W
K
F
I
R
N
V
K
E
QV-KI
P
V
I
VNGDI
K
S
L
N
D
I
Q
N
A
L
K
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SRAD
G
V
M
IGRGAYG-RP
W
L
I
N
Q
A
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FLSGSEVSEPT
A
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-
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K
L
S
I
I
L
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H
Y
D
N
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L
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YGND--A
G
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K
I
A
-
R
--
K
H
I
G
W
YSSGFKNS
S
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F
R
V
R
V-NNMT
D
S
M
E
V
K
E
N
-
I
V
S
F
-
F
SQV--
33
HHSearch
95.39
32%
-88
- C1 -
1VHN
4
?
A:
[5-307]
---
V
K
V
G
L
A
P
-
M
A
G
--------
Y
--------
T
---------
D
S
A
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A
F
--
E
W
-
G
-
A
D
-
F
-
A
F
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M
V
S
A
K
G
F
--
L
---------------------
M
--
N
----------------------
S
-----------
Q
---------
K
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T
-
E
-
E
---
L
L
PQ----
P
H
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N
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A
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Q
I
F
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------------------------
E
-----------------------
P
----------------------
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--
K
Y
K
W
I
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L
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C
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A
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N
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E
G
V
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F
I
H
T
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T
V
----------------------
V
----------------
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F
----
T
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--
R
----
A
---------
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W
K
A
L
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L
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K
---
R
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G
D
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T
P
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K
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M
-
F
Y
N
F
-
I
K
E
V
--
1
PsiBlast_PDB
93.38
32%
-88
- C1 -
1VHN
4
?
A:
[7-308]
-----
V
G
L
A
P
-
M
A
G
--------
Y
--------
T
---------
D
S
A
F
R
T
L
A
F
--
E
W
-
G
-
A
D
-
F
-
A
F
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M
V
S
A
K
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--
L
---------------------
M
NS
Q
----------------------
K
-----------
T
---------
E
-
E
-
L
-
L
---
P
Q
------
P
H
E
R
N
-
V
-
A
-----------
V
Q
I
F
G
S
------------------------
E
-----------------------
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
E
-
K
-
Y
K
W
I
D
L
N
A
G
---------
C
---------
P
V
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G
A
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A
L
L
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--
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K
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----------
E
--
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--
N
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V
E
E
I
Y
R
I
L
V
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E
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V
D
E
V
F
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H
T
R
T
V
----------------------
V
----------------
Q
--
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----
T
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G
--
R
----
A
---------
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W
K
A
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V
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V
Q
I
L
K
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M
-
F
Y
N
F
-
I
K
E
V
--
56
Fugue
90.31
32%
-84
- C1 -
1VHN
4
?
A:
[5-309]
---
V
K
V
G
L
A
P
M
A
-
G
--------
Y
--------
T
---------
D
S
A
F
R
T
L
A
F
--
E
W
-
G
-
A
D
-
F
-
A
F
S
E
M
V
S
A
K
G
F
L
M
-
N
---------------------
S
--
Q
----------------------
K
-----------
T
---------
E
-
E
-
L
-
L
---
P
Q
------
P
H
E
R
N
-
V
-
A
-----------
V
Q
I
F
G
S
------------------------
E
-----------------------
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
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--
K
Y
K
W
I
D
L
N
A
G
---------
C
---------
P
V
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V
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A
G
G
A
L
L
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L
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--
S
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K
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K
T
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L
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W
E
----
K
----
N
--
E
----
V
E
E
I
Y
R
I
L
V
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V
D
E
V
F
I
H
T
R
T
V
----------------------
V
----------------
Q
--
S
F
----
T
-
G
--
R
----
A
---------
E
W
K
A
L
S
V
L
E
K
R
---
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
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G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
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D
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G
K
Y
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L
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I
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V
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F
Y
N
F
-
I
K
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V
E-
58
Fugue
89.86
28%
-81
- C1 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
-
A
S
M
R
V
L
L
A
P
-
M
E
G
--------
V
--------
L
---------
D
S
L
V
R
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L
T
--
E
V
N
D
-
Y
D
-
L
-
C
I
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F
V
R
V
V
D
Q
--
L
---------------------
L
--
P
----------------------
V
-----------
K
---------
V
-
F
-
H
-
R
---
I
C
--------
P
E
L
-
Q
-
N
ASRTPS
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
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G
S
G
G
G
A
T
L
L
K
D
P
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R
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A
V
PA
H
L
P
V
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L
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----
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----
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--
E
--
K
-
K
F
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A
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A
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A
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E
L
V
V
H
G
R
T
K
----------------------
E
----------------
Q
--
G
Y
----
R
-
A
--
E
----
H
I--------
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
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C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
K
Y
-------
N
E
P
R
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P
W
P
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V
A
L
L
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Y
T
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K
L
--
57
Fugue
86.92
26%
-87
- C1 -
3B0P
1
DUSAL_THET8
A:
[2-318]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
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S
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--
L
---------------------
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--
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----------------------
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-----------
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-
L
---
A
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------
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Q
L
A
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------------------------
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----------------------
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L
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A
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-------------------------------------------
A
L
----
I
-
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--
P
----
L
---------
R
H
D
W
V
H
R
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G
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A
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R
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----
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V
GE
34
HHSearch
86.58
26%
-90
* C1 *
3B0P
1
DUSAL_THET8
A:
[2-315]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
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---------------------
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--
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----------------------
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-----------
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L
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A
---
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------
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Q
L
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------------------------
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A
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----------------------
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----------------------------IP
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----
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---------
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H
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P
W
A
V
-
L
--
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
E
G
R
S
L
Q
A
L
D
R
A
-
L
R
L
M
-
E
E
E
V
--
2
PsiBlast_PDB
82.63
27%
-69
- C1 -
4BFA
6
DUSC_ECOLI
A:
[26-330]
-----
V
L
L
A
P
-
M
E
G
--------
V
--------
L
---------
D
S
L
V
R
E
L
L
T
--
E
V
-
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
--
P
----------------------
V
-----------
K
V
F
H
R
I
C
PEL
Q
-
N
-
A
-
S
---
R
T
------
P
S
G
T
L
-
V
-
R
-----------
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
--
K
K
F
-
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
----------------------
E
----------------
Q
--
G
Y
----
R
-
A
--
E
----
H
I--------
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
-------
N
L
S
R
V
V
K
Y
N
E
P
R
M
P
-
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
--
G
L
Y
H
V
A
-
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
-
D
I
E
K
--
6
PsiBlast_PDB
81.18
26%
-66
- C1 -
4YCP
3
DUSC_ECOLI
A:
[9-313]
-----
V
L
L
A
P
-
M
E
G
--------
V
--------
L
---------
D
S
L
V
R
E
L
L
T
--
E
V
-
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
--
P
----------------------
V
-----------
K
V
F
H
R
I
C
PEL
Q
-
N
-
A
-
S
---
R
T
------
P
S
G
T
L
-
V
-
R
-----------
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
W
G
V
D
L
N
C
G
---------
A
---------
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
--
K
K
F
-
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
----------------------
E
----------------
Q
--
G
Y
----
R
-
A
--
E
----
H
I--------
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
-------
N
L
S
R
V
V
K
Y
N
E
P
R
M
P
-
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
--
G
L
Y
H
V
A
-
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
-
D
I
E
K
--
5
PsiBlast_PDB
80.94
26%
-68
- C1 -
4YCO
1
DUSC_ECOLI
A:
[9-313]
-----
V
L
L
A
P
-
M
E
G
--------
V
--------
L
---------
D
S
L
V
R
E
L
L
T
--
E
V
-
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
--
P
----------------------
V
-----------
K
V
F
H
R
I
C
PEL
Q
-
N
-
A
-
S
---
R
T
------
P
S
G
T
L
-
V
-
R
-----------
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
--
K
K
F
-
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
----------------------
E
----------------
Q
--
G
Y
----
R
-
A
--
E
----
H
I--------
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
-------
N
L
S
R
V
V
K
Y
N
E
P
R
M
P
-
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
--
G
L
Y
H
V
A
-
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
-
D
I
E
K
--
3
PsiBlast_PDB
79.08
31%
-109
- C1 -
3B0P
1
DUSAL_THET8
A:
[2-238]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
H
F
R
F
L
V
R
--
Q
V
-
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
--
G
----------------------
N
-----------
R
---------
E
-
R
-
L
-
L
---
A
F
------
R
P
E
E
H
-
P
I
A
-----------
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
----------------------
L
------------------------------------IPPLR
H
---
D
W
--
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
-
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
--
A
V
L
R
H
M
-
L
--
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
-
S
L
Q
A
L
D
R
A
L
R
L
M
-
E
E
E
V
-
G
E
----
7
PsiBlast_PDB
78.29
26%
-68
- C1 -
4BF9
1
DUSC_ECOLI
A:
[26-330]
-----
V
L
L
A
P
-
M
E
G
--------
V
--------
L
---------
D
S
L
V
R
E
L
L
T
--
E
V
-
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
--
P
----------------------
V
-----------
K
V
F
H
R
I
C
PEL
Q
-
N
-
A
-
S
---
R
T
------
P
S
G
T
L
-
V
-
R
-----------
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
-
L
G
S
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
L
P
V
S
V
K
V
R
L
G
W
D
----
S
----
G
--
E
--
K
K
F
-
E
I
A
D
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
K
----------------------
E
----------------
Q
--
G
Y
----
R
-
A
--
E
----
H
I--------
D
W
Q
A
I
G
D
I
R
Q
R
L
-
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
-------
N
L
S
R
V
V
K
Y
N
E
P
R
M
P
-
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
--
G
L
Y
H
V
A
-
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
V
L
N
N
S
P
D
I
A
R
A
-
I
Q
A
I
-
D
I
E
K
--
22
PsiBlast_CBE
77.95
31%
-107
- C1 -
3B0P
1
DUSAL_THET8
B:
[2-238]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
H
F
R
F
L
V
R
--
Q
V
-
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
--
G
----------------------
N
-----------
R
---------
E
-
R
-
L
-
L
---
A
F
------
R
P
E
E
H
-
P
I
A
-----------
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
TY
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
----------------------
L
------------------------------------IPPLRH---
D
W
--
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
-
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
--
A
V
L
R
H
M
-
L
--
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
-
S
L
Q
A
L
D
R
A
L
R
L
M
-
E
E
E
V
-
G
E
E
---
21
PsiBlast_CBE
77.41
31%
-108
- C1 -
3B0U
2
DUSAL_THET8
Y:
[2-238]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
H
F
R
F
L
V
R
--
Q
V
-
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
--
G
----------------------
N
-----------
R
---------
E
-
R
-
L
-
L
---
A
F
------
R
P
E
E
H
-
P
I
A
-----------
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
TY
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
----------------------
L
----------------
L
--
A
L
----
S
-
T
--
K
----
A
NREIPPLRH
D
W
--
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
-
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
--
A
V
L
R
H
M
-
L
--
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
-
S
L
Q
A
L
D
R
A
L
R
L
M
-
E
----------
8
PsiBlast_PDB
73.95
30%
-100
- C1 -
3B0V
1
DUSAL_THET8
C:
[29-259]
-------
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
H
F
R
F
L
V
R
--
Q
V
-
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
--
G
----------------------
N
-----------
R
---------
E
-
R
-
L
-
L
---
A
F
------
R
P
E
E
H
-
P
I
A
-----------
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
TY
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
----------------------
L
----------------
L
--
A
L
----
S
-
T
--
K
----
A
NREIPPLRH
D
W
--
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
-
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
--
A
V
L
R
H
M
-
L
--
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
-
S
L
Q
A
L
D
R
A
L
R
L
M
-
E
E
E
--------
4
PsiBlast_PDB
72.04
31%
-81
- C1 -
3B0U
3
DUSAL_THET8
X:
[2-238]
-
L
D
P
R
L
S
V
A
P
-
M
V
D
--------
R
--------
T
---------
D
R
H
F
R
F
L
V
R
--
Q
V
-
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
--
G
----------------------
N
-----------
R
---------
E
-
R
-
L
-
L
---
A
F
------
R
P
E
E
H
-
P
I
A
-----------
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
-
F
G
Y
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
V
P
V
T
V
K
M
R
L
G
L
E
----
G
----
K
--
E
TY
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
A
----------------------
L
----------------
L
--
A
L
----
S
-
T
--
K
----
A
NREIPPLRH
D
W
--
V
H
R
L
K
G
D
F
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
R
V
F
G
L
P
R
R
P
S
R
L
E
-
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
--
A
V
L
R
H
M
-
L
--
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
-
S
L
Q
A
L
D
R
A
L
R
L
M
-
E
----------
38
HHSearch
68.50
18%
-82
- C1 -
3HGJ
2
?
A:
[15-336]
-
L
K
N
R
L
A
M
S
P
-
M
C
Q
YSATLEGE
V
--------
T
---------
D
W
H
L
L
H
Y
P
T
R
A
L
G
-
G
-
V
G
-
L
-
I
L
V
E
-
A
T
A
V
E
P
L
--
G
---------------------
R
--
I
----------------------
S
PYDLGIWSEDH
L
---------
P
-
G
-
L
-
K
---
E
L
A
R
R
I
R
-
E
A
G
A
V
-
P
-
G
-----------
I
Q
L
A
H
A
------------------------
G
RKAGTARPWEGGKPLGWRVVGPS
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
-
A
G
F
Q
V
I
E
L
H
M
A
---------
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
PR
E
L
P
L
F
V
R
V
S
A
T
D
W
GEGG
W
----
S
--
L
--
E
D
T
L
A
F
A
R
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
V
----------------------
V
----------------
L
--
R
V
RIPL
A
-
P
--
G
----
F
---------
Q
V
P
F
A
D
A
V
R
K
R
V
-
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
-
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
P
E
V
P
P
Q
Y
Q
-
R
G
F
--------------------------------------------------------------------------
36
HHSearch
65.06
18%
-79
- C1 -
3GR7
3
NAMA_GEOKA
A:
[16-326]
-
L
K
N
R
I
V
M
S
P
-
M
C
M
--------
Y
--------
S
CDTKDGAVR
T
W
H
K
I
H
Y
P
A
R
A
V
G
-
Q
-
V
G
-
L
-
I
I
V
E
-
A
T
G
V
T
P
Q
--
G
---------------------
R
--
I
SERDLGIWSDD-----------
H
-----------
I
---------
A
-
G
-
L
-
R
---
E
L
V
G
L
V
K
-
E
H
G
A
A
-
I
-
G
-----------
I
Q
L
A
H
A
GRKSQVP
G
E
I
I
A
PSAVPFDDSSP-
T
-----------------------
P
KEMT
K
A
D
I
E
E
T
V
----------
Q
A
F
Q
N
G
A
R
R
A
K
E
-
A
G
F
D
V
I
E
I
H
A
A
HGY
L
I
N
E
F
L
S
---------
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
W
--
D
G
P
L
F
V
R
I
S
A
S
D
Y
----
H
PDGL
T
--
A
--
K
D
Y
V
P
Y
A
K
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
I
----------------------
V
----------------
P
A
R
M
N
----
V
Y
P
--
G
----
Y
---------
Q
V
P
F
A
E
L
I
R
R
E
A
-
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
-
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
E
-
R
G
W
R
F
------------------------------------------------------------------------
53
HHSearch
63.01
21%
-81
- C1 -
1EP3
2
PYRDB_LACLM
A:
[16-287]
-
L
K
N
P
I
I
P
A
S
-
G
C
F
--------
G
--------
F
---------
G
E
E
Y
A
K
Y
Y
D
--
L
N
-
K
-
L
G
-
S
-
I
M
V
K
-
A
T
T
L
H
P
R
--
F
GNPTPR
V
A
E
T
AS
G
M
L
N
AIGLQ
N
--
P
----------------------
G
-----------
L
---------
E
V
I
-
M
T
E
---
K
L
P
W
L
N
E
N
F
P
E
L
P
-
I
-
I
-----------
A
N
V
A
G
S
------------------------
E
-----------------------
E
----------------------
A
D
Y
V
A
V
C
A
K
I
G
D
A
A
N
V
K
A
I
E
L
N
I
S
---------
C
---------
P
N
V
K
----
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
--
K
V
P
L
Y
V
K
L
S
P
N
V
T
----------------
D
I
V
P
I
A
K
A
V
E
A
A
G
A
D
G
L
T
M
I
N
T
L
M
----------------------
G
V
R
F
D
LKTRQPILANI
T
G
--
G
L
----
S
-
G
--
P
AI
K
P
V
---------
A
L
K
L
I
H
Q
V
A
Q
D
V
-
D
I
P
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
-
A
G
A
S
A
V
A
V
G
T
A
N
F
A
-
D
P
F
V
C
P
K
I
I
D
K
L
P
E
L
M
D
Q
Y
R
I
E
S
-
L
E
S
L
I
Q
E
V
K
E
G
K
K
----------------------------------------------------------------
55
HHSearch
62.75
17%
-92
- C1 -
1GTE
2
DPYD_PIG
A:
[542-835]
-
F
I
N
P
F
G
L
A
S
-
A
A
P
--------
T
--------
T
---------
S
S
S
M
I
R
R
A
F
--
E
A
-
G
-
W
G
-
F
-
A
L
T
K
-
T
F
S
L
D
K
D
I
V
T
---------------------
N
--
V
S
PR
I
V
R
G
TTSGPMYGPGQS
S
F
L
N
IELISEKT---
A
---------
A
-
Y
-
W
C
Q
S
V
T
E
L
K
A
D
---
F
P
D
N
I
-
V
-
I
-----------
A
S
I
M
C
S
Y-----------------------
N
-----------------------
K
----------------------
N
D
W
M
E
L
S
R
K
A
E
A
-
S
G
A
D
A
L
E
L
N
L
S
---------
C
---------
P
H
G
M
G
------
L
A
C
G
Q
D
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
I
P
F
F
A
K
L
T
P
N
V
T
----------------
D
I
V
S
I
A
R
A
A
K
E
G
G
A
D
G
V
T
A
T
N
T
V
S
G
L
MGLKADGTPWPAVGAGKRT
T
Y
----------------
G
--
G
V
----
S
-
G
--
T
----
A
I
R
P
I
-----
A
L
R
A
V
T
T
I
A
R
A
L
P
G
F
P
I
L
A
T
G
G
I
D
S
A
E
S
G
L
Q
F
L
H
-
S
G
A
S
V
L
Q
V
C
S
A
V
Q
N
Q
D
F
T
V
I
Q
D
Y
C
T
G
L
K
A
L
L
Y
L
K
S
I
E
E
-
L
Q
G
W
D
G
Q
S
P
G
T
E
S
H
Q
K
G
K
P
V
--
P
R
I
A
E
L
-
M
--
G
K
K
L
P
N
F
G
P
Y
L
E
Q
R
K
K
I
I
A
E
-
E
K
M
R
L
K
E
Q
N
E
R
K
-
P
F
I
P
-
K
K
P
I
--
37
HHSearch
62.75
19%
-78
- C1 -
3KRU
2
?
A:
[15-325]
-
I
K
N
R
I
M
M
S
P
-
M
C
M
--------
Y
SASTDGMP
N
---------
D
W
H
I
V
H
Y
A
T
R
A
I
G
-
G
-
V
G
-
L
-
I
M
Q
E
-
A
T
A
V
E
S
R
--
G
---------------------
R
--
I
----------------------
T
DHDLGIWN
D
E
Q
V
---------
K
-
E
-
L
-
K
---
K
I
V
D
I
C
K
-
A
N
G
A
V
-
M
-
G
-----------
I
Q
L
A
H
A
GRKCNISYEDVVGPSPIKAGDRYK
L
-----------------------
P
RELS
V
E
E
I
K
S
I
V
----------
K
A
F
G
E
A
A
K
R
A
N
L
-
A
G
Y
D
V
V
E
I
H
A
A
HGY
L
I
H
E
F
L
S
---------
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
PE
N
K
P
I
F
V
R
V
S
A
D
D
Y
----
M
EGGI
N
--
I
--
D
M
M
V
E
Y
I
N
M
I
K
-
D
K
V
D
L
I
D
V
S
S
G
G
L
----------------------
L
----------------
N
VD
I
N
----
L
-
Y
P-
G
----
Y
---------
Q
V
K
Y
A
E
T
I
K
K
R
C
-
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
-
N
P
Y
W
V
L
H
T
Y
T
S
K
E
D
W
P
K
Q
Y
E
R
A
F
-
K
----------------------------------------------------------------------------