@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0201: (2016-03-13 )
MKKIISIAIIVLALVLSGCGVPTKSEVAQKSSKVEVKGERPTIHFLGQASYENDMNIVKDQLENAGFNVKMNIQPDYGSYRTQRQAGNYDIQIDDWMTVFGDPNYAMTALFSSTGSNSLLKDKHVDQLLNKASTQNEADVKQTYKQIEDEVVFDKGYMAPLYGSKKNLVYDNKVLDKNSVGLPNSRALIWQQFDYNNSRERDTRPLVMTQQDGEIPTLDPIRSIAPSVYSINMNMYTRLLLLDENDHLTTKGSLSRDYAVNKDNKAFYFLLRDDDYFAKVVNGQARNTGERVSAEDVKFSLDRARDKKSVPNNNTYNMHKHINDIKILKDEDIDQLRKEKDKDDKSIYDKLIKAYNVKSLTTDGQKVNNKDGIYQIVKITTDQSMPREVNYLTHSSAGILSKKFVNQVNQEYPKGYGDSSTIPANSDGKNALYASGAYIMTQKNAYQATFQRNPGFNETEKGSYGSPKIKNITLKFNGDPNNALSELRNHSIDMLADVNQKHFDLIKSDKNLSIIRKNGRKSVFLMLNIKKGIFKTHPNLRQAVVNAIDQDQFIKFYRGDKFKIASPITPLVDTGNEQRQDLEKVEKAINQ
Atome Classification :
(20 SA)
-.......-----..10...-.....20........30........40........50..--....-..60........70........80........90........100.......110-.......120.......130.......140.......150.......160........170........--180.......190.......200.......210........220--.---.--.---..--..-230--........240..--.--------....250...--..-..260-..-------------.....270--.......280.---......290----.....--...---.300......--------.310.--.-..------.---------..320....--...330.......340.......350.....-..360.......370.......380.-......390------.....-..--..400-.-......410-..-----.....-------420..--.---....430..---.....440..-.-....450.......460.......470......-.480.......490....-.-..500--.---......-.-510....-------...520--........-------------530-----........540..------.....550..-.-....--560--..-..-..---.570.....-----------------.---------..-.580.......590-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MK
K
I
I
S
I
-----
A
I
I
V
L
A
L
-
V
L
SGCGVP
T
K
S
E
V
AQKS
S
K
V
E
V
KGER
P
T
I
H
F
L
GQASYEN--
D
M
N
I
-
V
K
D
Q
L
ENAG
F
N
V
K
M
N
I
QPDYGSYRTQRQAGN
Y
D
I
Q
ID
D
W
M
T
VFGDP
N
Y
A
M
T
A
LFS-STGSNSLL
K
D
K
H
V
D
Q
L
L
N
KASTQ
N
E
A
D
V
K
Q
T
Y
K
Q
I
E
D
E
V
VFDKGYMAPL-YGSKKNLVYD-NKVLDKNS--VGLPNS
R
A
L
I
W
Q
QFDYNNSRERDTR
P
L
V
M
TQQ-DGEIP
T
L
D
P
I
R
--
S
---I--A---P
S
--
V
Y
-
S
-
I
--NM
N
M
Y
T
R
L
L
L
LDE--N--------DHLTTKGSLS--RD-YAVNK-DN-------------
K
A
F
Y
F
L
L
R--DD
D
Y
F
A
K
V
VNG---QARNTGE------RV
S
A
E
--
D
V
K
---
F
S
L
D
RARDKK--------SVPNN--N-T
Y
------
N
---------
M
H
KHIN
D
I
K
--ILKDE
D
I
D
Q
L
R
K
EKDKD
D
K
S
I
Y
D
K
L
I
K
A
YNV-KSLTTDGQKVNNKDG
I
Y
Q
I
V
K
ITTDQ-SMPREV
N
--------
Y
L
THS-S
A
--
G
I
L
S
K
-
K
-
F
V
N
Q
V
N
Q
EY-PK-----GYGDS-------STIPA--N---SDGKN
A
L
YA---S
G
A
Y
I
M
T
QKN-
A
-
Y
Q
A
T
FQRNPGFNETEKGSYGSP
K
I
K
N
I
T
L
K
FNG-DPN
N
A
L
S
E
L
R
NHS
I
D
M
L
A
-D-V
N
Q
-
K
--
H
---
F
D
L
I
KS-D-K
N
L
S
I
I
R-------KNG
R
K
---
S
V
F
L
M
L
NI-------------KK------
G
I
F
KTHP
N
L
R
Q
A
V
------
V
N
AI
D
Q
D
Q
F
I
-
K
-
F
YRG--D
K
F
--
K
I-AS-PI---TP--LVDTG-----------------
N
---------
E
Q
-
R
Q
D
L
E
K
V
E
K
A
INQ--------
16
HHSearch
87.87
21%
-43
- C5 -
1UQW
11
GSIB_ECOLI
A:
[23-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
K
D
V
V
V
A
V
--
G
S
N
F
T
T
L
D
P
Y
D
--
A
---
N
--
D
---
T
L
--
S
Q
-
A
-
V
--
A
K
S
F
Y
Q
G
L
F
G
L
D
K
--
E
--------
M
K
L
K
--
N
V
L
A
--
E
S
-
Y
T
V
S
D
-
D
G
-------------
I
T
Y
T
V
K
L
R
--
E
G
I
K
F
Q
------------
D
G
T
------
D
F
N
A
A
--
A
V
K
---
A
N
L
D
R
A
S
D
P
A
--------
N
H
L
K
R
-----
H
------
N
---------
L
Y
K
N
I
A
K
T
E
--
A
I
D
--------------------------------------------
P
T
-
T
V
K
I
T
L
K
Q
-
P
F
S
A
F
I
N
--------
I
L
A
H
P
-
A
T
--
A
M
I
S
P
-
A
-
A
L
E
K
Y
G
K
----------------------------------
E
I
G
F
Y
P
V
G
---
T
G
P
Y
E
L
D
T
W
N
Q
T
-
D
F
V
K
V
K
K
F
A
G
Y
W
Q
P
-----
G
L
P
K
L
D
S
I
T
W
R
P
V
A
-
D
N
N
T
R
A
A
M
L
Q
T
G
E
A
Q
F
A
F
-
P
-
I
P
Y
-
E
--
Q
---
A
T
L
L
E
K
-
N
-
K
N
I
E
L
M
A
-------
S
P
S
I
M
---
Q
R
Y
I
S
M
N
V
-------------
T
Q
-------
K
P
F
D
N
P
K
V
R
E
A
L
------
N
Y
A
I
N
R
P
A
L
V
-
K
V
A
F
A
G
--
Y
A
T
--
P
A
-
T
G
-
V
V
---
P
P
--
S
I
A
Y
A
Q
S
Y
--------------
K
---------
P
W
-
P
Y
D
P
V
K
A
R
E
L
L
K
E
--------
19
HHSearch
85.25
20%
-38
- C5 -
3TPA
-
?
A:
[8-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
L
V
N
C
I
--
A
T
A
P
M
K
L
S
P
A
I
--
T
---
N
--
D
---
A
N
--
D
F
-
N
A
S
--
S
Q
Q
V
Y
N
R
L
V
E
F
K
A
G-
K
--------
I
E
V
E
--
P
G
L
A
--
E
R
-
W
E
I
S
E
-
D
G
-------------
L
V
Y
T
F
Y
L
R
--
Q
N
V
K
F
H
S
---
N
---
K
T
F
S
P
T
R
------
P
L
N
A
D
--
D
V
V
---
F
S
F
Q
R
Q
A
D
K
N
--------
H
P
Y
H
N
VS
A
G
T
Y
F
Y
F
N
W
M
N
---------
L
P
S
I
L
K
S
V
E
--
K
V
D
--------------------------------------------
D
Y
-
T
V
K
I
T
L
N
K
-
P
N
T
P
F
I
T
--------
T
V
A
M
D
-
F
L
--
S
I
Y
S
K
-
E
-
Y
A
D
Q
L
L
A
Q
-----------
G
K
---------------
P
---
E
T
L
D
Q
Q
P
I
G
---
T
G
P
F
I
F
Q
T
N
Q
T
D
-
H
A
V
R
Y
T
A
N
V
D
Y
W
K
------
G
K
A
D
I
E
R
L
I
F
S
I
T
P
-
D
A
G
T
R
Y
A
K
L
K
A
G
E
C
D
V
I
D
-
F
-
P
N
I
-
S
--
D
---
I
A
Q
M
K
K
-
D
-
P
Q
I
N
L
L
E
-------
R
E
G
L
N
---
L
A
Y
I
G
L
N
T
-------------
T
K
-------
P
E
L
N
N
V
K
V
R
Q
A
L
------
H
H
A
T
D
K
K
A
I
V
-
D
A
V
Y
Q
G
--
G
G
T
--
V
A
-
T
N
-
P
F
---
P
D
--
A
V
L
G
Y
-----------------
N
PHLP-----
Q
Y
-
E
F
N
L
E
K
A
K
A
L
L
A
E
--------
20
HHSearch
83.19
20%
-29
- C5 -
1JET
5
OPPA_SALTY
A:
[10-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
Q
T
L
V
R
N
N
--
G
S
E
V
Q
S
L
D
P
H
K
--
I
---
E
--
G
---
V
P
--
E
S
-
N
-
V
--
S
R
D
L
F
E
G
L
L
I
S
D
V
--
E
--------
G
H
P
S
--
P
G
V
A
--
E
K
-
W
E
N
-
K
-
D
F
-------------
K
V
W
T
F
H
L
R
--
E
N
A
K
W
S
------------
D
G
T
------
P
V
T
A
H
--
D
F
V
---
Y
S
W
Q
R
L
A
D
P
N
--------
T
A
S
P
Y
--
A
-
S
Y
------
L
---------
Q
Y
G
H
I
A
N
I
D
--
D
I
I
A
-------------
G
K
----
K
P
A
T
D
L
G
V
-
K
A
L
D
-----------
D
H
-
T
F
E
V
T
L
S
E
-
P
V
P
Y
F
Y
K
--------
L
L
V
H
P
-
S
V
--
S
P
V
P
K
-
S
-
A
V
E
K
F
G
D
K
--------------------------------
W
T
Q
P
A
N
I
V
T
---
N
G
A
Y
K
L
K
N
W
V
V
N
-
E
R
I
V
L
E
R
N
P
Q
Y
W
D
N
-----
A
K
T
V
I
N
Q
V
T
Y
L
P
I
S
-
S
E
V
T
D
V
N
R
Y
R
S
G
E
I
D
M
T
Y
N
N
-
M
P
I
-
E
--
L
---
F
Q
K
L
K
K
-
E
-
I
P
N
E
V
R
V
-------
D
P
Y
L
C
---
T
Y
Y
Y
E
I
N
N
-------------
Q
K
-------
A
P
F
N
D
V
R
V
R
T
A
L
------
K
L
A
L
D
R
D
I
I
V
-
N
K
V
K
N
Q
--
G
D
L
--
P
A
-
Y
S
-
Y
T
---
P
P
--
Y
T
D
G
A
-----------------
K
L
V
E
P
EWFKW
S
Q
-
Q
K
R
N
E
E
A
K
K
L
L
A
E
--------
24
HHSearch
78.27
18%
-49
- C5 -
3T66
1
?
A:
[12-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
H
I
H
F
L
F
--
N
V
S
T
N
S
L
D
P
H
V
--
D
---
M
--
T
-------
Y
I
-
P
-
V
--
R
A
G
I
T
E
T
L
V
R
V
D
E
--
E
N-------
V
T
I
A
--
P
W
L
A
--
E
S
-
W
D
S
-
T
-
D
G
-------------
Q
H
W
T
I
K
L
R
--
E
D
V
T
F
Q
------------
N
G
K
------
E
M
D
A
E
--
A
V
K
---
A
S
L
E
R
A
L
D
E
S
--------
V
A
I
--------------
E
---------
N
A
L
K
I
D
E
I
E
--
A
-
D
--------------------------------------------
G
Y
-
T
L
H
I
T
T
K
E
-
P
F
P
E
F
I
S
--------
E
L
V
N
P
-
N
V
--
S
I
I
D
V
-
T
-
E
---------------------------------------
E
D
F
T
N
H
P
V
G
---
T
G
P
F
A
L
E
S
F
T
P
G
-
S
K
L
E
L
V
R
Y
D
E
Y
W
D
------
G
A
S
K
L
D
S
V
T
F
S
F
N
E
-
D
A
S
A
R
S
L
A
L
E
S
G
Q
A
D
I
V
Y
-
R
-
P
E
V
-
E
--
S
---
I
E
T
L
Q
A
-
N
-
E
G
I
M
V
E
A
-------
T
E
T
F
R
---
T
H
N
L
T
M
N
L
-------------
D
R
-------
D
S
L
K
D
V
N
V
R
R
A
V
------
D
V
L
L
D
R
Q
E
I
V
-
D
T
I
M
L
G
--
Y
A
E
--
V
A
-
D
G
-
P
F
---
I
P
--
T
L
P
F
A
PSY--------------
E
---------
K
K
-
E
T
G
T
D
I
A
I
Q
Y
L
E
E
--------
22
HHSearch
77.73
20%
-40
- C5 -
1DPE
3
DPPA_ECOLI
A:
[1-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
V
Y
C
S
--
E
G
S
P
E
G
F
N
P
Q
L
--
F
---
I
--
S
---
G
T
--
T
Y
D
A
-
S
--
S
V
P
L
Y
N
R
L
V
E
F
K
I
G-
T
--------
T
E
V
I
--
P
G
L
A
--
E
K
-
W
E
V
S
E
-
D
G
-------------
K
T
Y
T
F
H
L
R
--
K
G
V
K
W
H
------------
D
N
K
EFKPTR
E
L
N
A
D
--
D
V
V
---
F
S
F
D
R
Q
K
N
A
Q
--------
N
P
Y
H
K
--
V
-
S
G
------
G
SY
E
Y
F
E
G
M
G
L
P
E
L
I
S
----------------------------------
E
V
-
K
K
V
D
-----------
D
N
-
T
V
Q
F
V
L
T
R
-
P
E
A
P
F
L
A
--------
D
L
A
M
D
-
F
A
--
S
I
L
S
K
-
E
-
Y
A
D
A
M
M
K
-----------
A
G
T
---------------
P
---
E
K
L
D
L
N
P
I
G
---
T
G
P
F
Q
L
Q
Q
Y
Q
K
D
-
S
R
I
R
Y
K
A
F
D
G
Y
W
G
------
T
K
P
Q
I
D
T
L
V
F
S
I
T
P
-
D
A
S
V
R
Y
A
K
L
Q
K
N
E
C
Q
V
M
P
-
Y
-
P
N
P
-
A
--
D
---
I
A
R
M
K
Q
-
D
-
K
S
I
N
L
M
E
-------
M
P
G
L
N
---
V
G
Y
L
S
Y
N
V
-------------
Q
K
-------
K
P
L
D
D
V
K
V
R
Q
A
L
------
T
Y
A
V
N
K
D
A
I
I
-
K
A
V
Y
Q
G
--
A
G
V
--
S
A
-
K
N
-
L
I
---
P
P
--
T
M
W
G
Y
-----------------
N
DDVQ-----
D
Y
-
T
Y
D
P
E
K
A
K
A
L
L
K
E
--------
21
HHSearch
73.30
19%
-49
- C5 -
3RQT
6
?
A:
[21-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
L
N
I
S
L
--
P
L
K
T
K
S
I
A
P
Y
E
--
T
--------------
D
V
-
P
-
V
--
K
I
G
A
A
E
S
L
F
K
T
N
D
--
Q
--------
G
K
I
E
--
K
A
L
V
--
K
S
-
Y
H
Q
P
--
N
D
-------------
T
T
L
D
I
E
L
K
--
D
N
I
K
F
Q
------------
N
G
Q
------
K
L
T
A
E
--
K
V
K
---
S
S
L
E
N
S
M
K
K
S
--------
D
L
V
K
-----------------------
Y
S
L
P
I
S
S
I
T
--
A
K
---------------------------------------------
G
-
Q
K
L
T
I
K
T
N
S
-
A
Y
P
E
L
V
S
--------
E
L
A
N
P
-
F
M
--
A
I
Y
D
T
-
D
-
A
K
S
--------------------------------------
D
V
N
Q
T
P
V
G
---
T
G
P
Y
Q
I
K
D
Y
K
Q
S
-
R
K
I
S
L
S
N
F
K
D
Y
W
Q
------
G
K
P
K
L
D
H
I
T
V
T
Y
Q
E
-
D
G
N
N
R
V
R
N
L
E
S
Q
K
D
D
L
I
T
-
D
-
V
P
V
-
N
--
K
---
V
Q
D
I
E
N
-
N
-
Q
N
L
K
V
S
K
-------
E
S
G
F
R
---
T
S
L
L
M
Y
N
H
-------------
T
N
-------
K
K
M
-
T
K
S
V
R
E
A
L
------
D
H
I
I
D
R
Q
G
I
A
-
D
H
I
Y
Q
G
--
Y
A
K
--
P
A
-
T
S
-
P
F
---
N
D
--
K
I
P
Y
I
-----------------
K
EPK------
L
T
-
K
Q
N
I
E
Q
A
K
M
L
L
A
K
--------
17
HHSearch
73.23
19%
-38
- C5 -
1XOC
12
APPA_BACSU
A:
[19-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
G
G
D
L
V
V
G
S
--
I
G
E
P
T
L
F
N
S
L
Y
--
S
---
T
--
D
---
D
A
--
S
T
-
D
-
I
--
E
N
M
L
Y
S
F
L
T
K
T
D
E
--
K
--------
L
N
V
K
--
L
S
L
A
--
E
S
-
I
K
E
L
D
-
G
G
-------------
L
A
Y
D
V
K
I
K
--
K
G
V
K
F
H
------------
D
G
K
------
E
L
T
A
D
--
D
V
V
---
F
T
Y
S
V
P
L
S
K
D
--------
Y
K
G
E
R
-----
G
------
S
---------
T
Y
E
M
L
K
S
V
E
--
K
K
G
--------------------------------------------
D
Y
-
E
V
L
F
K
L
K
Y
-
K
D
G
N
F
Y
N
--------
N
A
L
D
--
S
T
--
A
I
L
P
K
-
H
-
I
L
G
N
V
P
I
A
D
---------
L
-------------
E
E
--
N
---
E
F
N
R
K
K
P
I
G
---
S
G
P
F
K
F
K
E
W
K
Q
G
-
Q
Y
I
K
L
E
A
N
D
D
Y
F
E
------
G
R
P
Y
L
D
T
V
T
Y
K
V
I
P
-
D
A
N
A
A
E
A
Q
L
Q
A
G
D
I
N
F
F
N
---
V
P
A
-
T
--
D
---
Y
K
T
A
E
K
-
F
-
N
N
L
K
I
V
T
-------
D
L
A
L
S
---
Y
V
Y
I
G
W
N
E
-------------
K
N
-------
E
L
F
K
D
K
K
V
R
Q
A
L
------
T
T
A
L
D
R
E
S
I
V
-
S
Q
V
L
D
G
--
D
G
E
--
V
A
-
Y
I
-
P
E
---
S
P
--
L
S
W
N
Y
-----------------
P
KDIDVP---
K
F
-
E
Y
N
E
K
K
A
K
Q
M
L
A
E
--------
30
HHSearch
71.86
17%
-50
- C5 -
2O7I
1
?
A:
[6-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
E
D
T
V
Y
I
G
G
A
L
W
G
P
A
T
T
W
N
L
Y
A
--
P
---
Q
--
S
-------
T
W
-
G
-
T
--
D
Q
F
M
Y
L
P
A
F
Q
Y
D
L
--
G
R-------
D
A
W
I
--
P
V
I
A
--
E
R
-
Y
E
F
V
--
D
D
-------------
K
T
L
R
I
Y
I
R
--
P
E
A
R
W
S
------------
D
G
V
------
P
I
T
A
D
--
D
F
V
---
Y
A
L
E
L
T
K
E
L
G
--------
I
G
P
-
G
-----
G
------
G
---------
W
D
T
Y
I
E
Y
V
K
--
A
V
D
--------------------------------------------
T
K
-
V
V
E
F
K
A
K
E
-
E
N
L
N
Y
F
Q
--------
F
L
S
Y
S
L
G
A
--
Q
P
M
P
K
-
H
-
V
Y
E
R
I
R
A
Q
M
-
N
-------
I
K
----------
D
W
----
I
---
N
D
K
P
E
E
Q
V
V
---
S
G
P
Y
K
L
Y
Y
Y
D
-
P
-
N
I
V
V
Y
Q
R
V
D
D
W
W
G
K
D
I
--
F
G
L
P
R
P
K
Y
L
A
H
V
I
Y
K
-
D
N
P
S
A
S
L
A
F
E
R
G
D
I
D
W
N
G
-
L
-
F
I
P
-
S
--
V
---
W
E
L
W
E
K
---
K
G
L
P
V
G
T
WYKKEPY
F
I
P
D
G
---
V
G
F
V
Y
V
N
N
-------------
T
K
-------
P
G
L
S
D
P
A
V
R
K
A
I
------
A
Y
A
I
P
Y
N
E
M
L
-
K
K
A
Y
F
G
--
Y
G
S
--
Q
A
-
H
P
S
M
V
---
I
D
--
L
F
E
P
Y
KQYID
Y
E
L
A
K
K
T
FGTED
G
---------
R
I
-
P
F
D
L
D
M
A
N
K
I
L
D
E
--------
31
HHSearch
67.67
16%
-30
- C5 -
2D5W
1
?
A:
[3-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
D
N
S
L
V
I
G
A
--
S
Q
E
P
R
V
L
A
G
D
F
LR
V
---
I
SN
Q
---
A
I
--
K
S
-
E
-
I
--
E
Q
Y
L
F
A
P
F
I
G
F
N
A
--
D
--------
S
Q
N
F
--
P
V
L
A
--
T
E
-
V
P
T
L
E
-
N
G
R
L
R
V
T
D
IGGG
K
K
R
L
E
M
D
I
T
I
R
--
P
D
A
K
W
S
------------
D
G
R
------
P
I
T
T
E
--
D
V
A
---
F
Y
F
E
V
G
K
A
K
G
--------
M
P
V
L
N
-----
P
----------------
D
F
W
E
R
V
N
V
R
--
I
K
D
--------------------------------------------
A
R
-
N
F
T
L
I
F
E
P
-
A
Y
Y
-
Y
D
T
--------
Y
G
P
---
I
N
--
T
Y
A
P
K
-
H
-
I
M
G
P
E
W
E
R
V
K
A
A
A
R
G
LD
P
D
K
D
A
E
K
L
N
E
L
Y
R
N
F
F
L
K
F
A
T
P
Q
A
L
N
R
G
A
M
V
Y
---
S
G
P
F
K
L
K
R
W
V
P
G
-
N
S
I
E
M
E
R
N
P
N
F
P
I
K
P
E
G
-
G
E
S
K
Y
V
Q
K
V
V
Y
R
F
I
Q
-
N
T
N
S
L
L
V
A
V
I
G
G
S
I
D
A
T
S
-
S
-
V
S
L
-
T
F
D
Q
G
R
S
P
Q
L
V
R
R
A
P
-
G
R
F
D
I
W
F
-------
V
P
G
A
I
---
W
E
H
I
D
I
N
K
-------------
F
E
NC
Q
V
V
K
D
L
G
L
N
D
K
R
T
R
Q
A
I
------
L
H
A
L
N
R
E
G
L
V
-
K
A
F
F
D
G
--
L
Q
P
--
V
A
-
H
T
-
W
I
---
A
P
--
V
N
P
L
F
-----------------
N
PN
V
K
-----
K
Y
-
E
F
D
L
K
K
A
E
A
L
L
A
E
--------
41
Fugue
67.30
20%
15
* C3 *
3LM3
3
?
A:
[13-448]
E
P
L
T
I
E
G
N
-----
R
F
V
T
L
C
I
M
I
R
T
-----
T
P
W
E
V
S
R
D
----------
V
K
L
H
P
R
D
E
V
D
W
H
T
--------------------------
L
E
G
V
R
A
L
R
E
A
F
A
T
-----------
N
N
P
N
G
R
L
T
W
G
F
T
M
N
A
-----
L
E
D
G
------
R
K
N
Y
R
E
I
R
D
Y
V
V
E
C
Q
K
K
Y
G
D
E
V
T
Y
F
P
G
Y
F
-
P
A
M
Y
L
P
R
E
R
V
N
R
E
M
S
E
A
I
E
I
I
S
K
M
V
G
N
-------------------
G
Y
R
P
-----------------
Q
--
S
---
I
M-
G
---
G
F
--
L
S
-
A
-
D
--
N
L
----
R
Y
L
A
E
K
E
--
N
--------
I
H
V
A
H
A
V
I
W
S
--
Q
H
-
N
G
G
G
A
-
D
G
-------------
S
P
S
Y
P
F
Y
P
--
S
T
E
H
F
C
K
P
A
Q
G
----
K
S
D
F
I
D
------
C
V
N
L
D
--
G
W
T
M--
D
F
I
C
A
R
R
S
G
Q
--------
T
G
H
G
I
--
D
-
G
Y
------
N
---------
S
R
R
G
V
G
P
I
E
--
T
Y
K
G
W
G
L
D
L
G
H
R
E
-----------------
V
M
H
T
E
A
I
H
F
D
K
G
L
E
L
N
G
F
G
W
V
A
N
I
W
E
A
Q
M
V
H
E
F
G
K
D
--------
L
I
C
D
A
----------
M
K
M
W
V
T
G
T
K
E
R
W
-
P
D
-----
T
---------------------------
H
F
V
T
---
F
G
E
F
G
E
L
W
R
K
-
Q
-
Y
K
S
N
D
D
W
N
Y
R
F
V
E
R
G
S
G
L
G
D
S
Y
N
--
N
L
E
I
K
W
F
-
M
N
K
E
F
R
L
A
L
L
R
D
W
H
T
K
----
N
-
S
P
A
-
Y
--
V
---
I
D
F
T
R
Y
-
D
--------------------------
L
Q
A
H
E
-------------
P
A
------
D
P
S
P
E
K
P
A
K
D
W
S
L
------
I
N
K
I
N
Q
------------------
K
A
-
L
R
-
P
Q
---
D
K
--
P
V
L
I
D
-----------------
K
---------
L
E
-
K
E
D
Q
D
L
I
R
K
Y
Y
P
E
LL------
44
Fugue
64.52
18%
20
- C4 -
4P0G
9
MLTF_PSEAE
A:
[7-435]
---------------------------
A
P
T
A
L
E
R
V
Q
K
E
G
V
L
R
V
I
T
R
N
S
P
A
T
Y
F
Q
D
R
N
G
E
T
G
F
E
Y
E
L
-
A
K
R
F
A
E
R
L
G
V
E
L
K
I
E
T
A
D
N
L
D
D
L
Y
A
Q
L
S
R
E
-------------
G
G
P
A
L
A
A
A
G
L
T
P
-
G
R
E
D
D
A
S
V
R
Y
S
H
------------------
T
Y
L
D
V
T
P
Q
I
I
Y
R
N
G
Q
Q
R
P
---
T
R
P
E
D
L
V
G
K
-
R
I
M
V
L
K
G
S
-----
S
H
A
E
Q
L
A
E
L
K
K
Q
Y
---------
P
E
L
K
Y
E
E
-
S
D
A
V
E
V
V
D
L
L
R
--
M
---
V
--
D
---
V
G
--
D
I
-
D
-----------
L
T
L
V
D
S
--
N
--------
E
L
A
M
N
Q
V
Y
F
P
NV
R
V
-
A
F
D
F
G
-
E
A
-------------
R
G
L
A
W
A
L
P
G
G
D
D
D
S
L
M
N
E
V
N
A
F
L
D
Q
A
K
K
E
G
L
------
L
Q
R
L
K
--
D
R
Y
---
Y
G
-----
H
V
D
--------
V
L
G
Y
V
--
G
-
A
Y
------
T
---------
F
A
Q
H
L
Q
Q
R
L
--
P
R
Y
E
S
H
F
K
Q
S
G
K
Q
L
D
T
D
----
W
R
L
L
A
A
I
G
Y
Q
-
E
S
L
W
Q
P
G
A
--
T
S
K
T
G
V
R
G
L
M
M
L
T
N
R
T
-
A
Q
A
M
G
V
S
-----------------------------------------------------------
N
--
R
---
L
D
P
K
Q
S
I
Q
G
---
G
S
K
Y
F
V
Q
I
R
S
-
E
-
L
P
E
S
I
K
----------------------------
E
P
D
R
S
W
F
A
L
A
A
Y
N
I
G
------------------------
G
-
A
H
L
E
D
A
R
-------
K
M
A
E
K
---
E
-------------------------------
G
L
N
P
N
K
W
L
D
V
------
K
K
M
L
P
R
L
A
Q
K
-
Q
-
W
Y
A
K
--
T
R
Y
--
G
Y
-
A
R
--------------
G
-----------------
G
---------
E
T
-
V
H
F
V
Q
N
V
R
R
Y
Y
D
I
L
T
W
V
T
Q
P
Q
28
HHSearch
64.11
16%
-43
- C5 -
3RY3
-
?
A:
[33-342]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
L
A
I
--
G
D
E
--
G
F
D
P
M
L
--
G
---
W
--
S
---
H
G
--
S
-------
Y
L
L
L
H
S
P
L
L
K
Q
N
E
--
D
--------
F
S
W
D
--
S
L
L
L
--
S
Q
-
Y
Q
P
S
D
-
D
G
-------------
K
T
W
L
L
T
L
K
--
P
D
L
K
F
S
------------
D
G
S
------
P
L
T
A
K
--
D
V
A
---
F
T
Y
N
N
A
A
A
S
G
--------
G
K
---------------
V
---------
D
M
G
N
F
L
S
A
E
--
V
I
D
--------------------------------------------
P
L
-
N
V
R
I
H
L
K
A
-
P
Q
S
T
F
V
N
--------
V
L
G
S
---
L
--
G
I
V
S
A
-
D
-
K
Y
N
A
K
------------------------------------
T
Y
A
Q
K
P
I
G
---
A
G
P
Y
R
L
V
S
F
Q
P
G
-
Q
Q
M
I
V
E
A
N
P
Y
Y
A
G
------
N
K
N
D
F
D
K
L
I
F
V
F
L
D
-
E
-
D
S
A
F
A
A
A
Q
S
G
Q
L
G
V
V
R
---
I
P
P
-
S
--
M
---
A
V
G
S
---
V
-
N
N
M
K
L
W
V
-------
R
P
S
V
E
---
N
R
G
I
V
F
P
T
T
P
A
GKKDAHGYPI
G
N
-------
D
V
T
A
D
V
A
I
R
R
A
I
------
N
Y
A
I
N
R
Q
L
L
A
-
D
Q
I
M
E
G
--
H
A
I
--
P
A
-
Y
T
-
G
V
---
Q
G
--
L
P
W
N
N
PDS--------------
A
---------
I
K
-
D
G
D
I
D
K
A
K
Q
I
L
E
Q
--------
29
HHSearch
62.22
13%
-35
- C5 -
1ZU0
1
?
A:
[12-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
V
R
N
F
N
P
Y
L
--
A
---
T
--
N
-------
L
R
-
T
-
T
--
T
D
F
I
Y
E
P
L
V
V
F
N
E
--
M
KG------
N
T
P
V
--
F
R
L
A
--
E
S
-
Y
K
M
A
D
-
D
L
-------------
M
S
V
T
F
D
I
R
--
K
G
V
K
W
S
------------
D
G
E
------
A
F
T
A
D
--
D
V
V
---
Y
S
F
G
L
L
K
A
K
P
--------
E
L
D
Q
------
R
------
G
---------
I
N
K
W
V
T
S
V
E
--
K
V
D
--------------------------------------------
E
Y
-
K
V
R
F
R
L
S
E
-
A
N
S
N
V
P
Y
--------
E
I
S
L
---
I
--
P
I
V
A
E
-
H
-
V
W
K
D
V
K
D
P
----------------------------
T
---
T
F
T
N
E
N
P
V
G
---
T
G
P
F
T
V
I
D
T
F
T
P
-
Q
L
Y
I
Q
C
R
N
P
N
Y
W
D
A
-----
A
N
L
E
V
D
C
L
R
V
P
Q
I
A
-
N
N
D
Q
L
L
G
K
I
V
N
S
E
L
D
W
T
S
-
S
-
F
V
P
-
D
--
I
---
D
R
T
Y
A
A
-
A
-
N
P
N
H
H
Y
W
-------
Y
P
A
A
G
---
T
Q
A
F
M
V
N
F
-------------
K
N
PD
P
A
K
-
K
E
A
L
D
N
V
D
F
R
R
A
F
------
S
M
A
L
D
R
Q
T
I
I
-
D
I
A
F
Y
G
--
S
G
T
--
V
N
-
D
F
-
A
S
---
G
L
GY
A
F
E
A
W
SD
E
A
T
H
K
K
Y
K-------
G
---------
F
N
-
T
Y
D
V
E
G
S
K
K
L
L
A
K
--------
40
Fugue
61.33
15%
8
* C4 *
4Z2T
1
?
A:
[11-591]
-
A
E
T
D
V
L
I
V
G
AG
P
A
G
A
M
S
A
T
-
L
L
A
S
L
G
I
R
S
L
M
I
N
R
W
R
S
T
S
-----
P
G
P
R
S
H
I
I
N
Q
R
T
M
E
I
--
L
R
D
I
G
L
E
E
S
A
K
S
L
A
V
P
K
E
Y
M
G
E
H
V
Y
A
T
S
L
A
G
E
E
F
G
----
R
I
P
A
W
A
S
--
H
P
Q
A
H
A
E
H
E
L
A
S
-
P
S
R
Y
C
D
L
P
Q
L
Y
F
E
P
M
V
V
S
E
A
A
L
R
G
-
A
D
V
R
F
-
L
T
E
Y
L
G
H
V
E
D
Q
D
G
V
T
A
R
L
-
L
D
H
V
S
G
--
A
E
-
Y
E
V
R
A
K
Y
I
--
I
G
A
D
G
A
H
S
L
V
A
Q
N
A
G
L
P
F
E
G
Q
M
G
G
S
I
N
I
E
F
S
A
-
D
--------
L
S
--
S
---
L
--
C
---
E
H
--
R
K
-
G
-
D
--
M
Y
Y
M
F
V
A
A
L
R
M
I
R
PW
N
--------
K
W
I
C
V
W
G
E
I
T
--
K
E
-----
E
-
A
K
-------------
K
I
I
H
E
I
I
G
--
T
D
E
I
P
V
E
V
G
P
I
---
S
T
W
T
I
N
Q
------
Q
Y
A
V
R
--
N
T
S
GR
V
F
C
M
G
D
A
V
H
R
H
T
PMGGL
G
L
N
T
S
V
Q
--
D
-
A
Y
------
N
---------
L
A
W
K
L
A
L
V
L
K
G
T
A
A
P
T
L
L
D
S
Y
D
A
E
R
S
P
V
A
K
Q
I
V
E
R
A
F
K
S
L
S
T
-
F
P
P
V
F
E
A
L
S
L
P
P
A
P
--------
T
E
S
E
-
M
A
E
A
L
V
R
--------
L
K
D
A
S
-
E
E
--
G
A
K
R
R
-
A
-
A
L
R
K
A
M
D
A
T
-
I
I
-----
G
L
G
G
G
-------
H
G
V
E
L
--
N
---
Q
R
-----
Y
V
---
S
R
A
--
V
F
P
D
G
-
T
-
P
D
P
G
F
V
R
D
Q
E
F
F
Y
Q
A
S
T
R
P
G
A
-
H
L
P
H
V
W
L
T
E
N
Q
-
R
R
I
S
T
L
D
L
C
G
K
G
R
F
T
L
L
T
-
G
-
L
S
G
-
A
--
A
---
W
K
H
E
A
E
-
Q
-
V
S
Q
S
L
-----------
G
I
E
---
L
K
V
C
V
I
G
P
-------------
G
Q
------
E
F
V
D
T
Y
G
E
Y
A
K
I
S
EIGES
G
A
L
L
V
R
P
D
M
F
I
-
A
-
F
R
A
K
--
D
A
---------------------------------------------------
S
-
R
E
G
L
E
Q
L
N
V
A
V
K
S
I
L
GR----
25
HHSearch
60.42
14%
-40
- C5 -
2GRV
-
LPQW_MYCS2
A:
[25-414]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
Q
I
I
M
A
I
--
D
S
I
G
P
G
F
N
P
H
L
--
L
---
S
--
D
---
Q
S
P
V
N
A
-
A
-
I
--
A
S
L
V
L
P
S
S
F
R
P
V
P
--
D
PTSPTG
S
R
W
E
L
D
--
T
T
L
L
--
E
S
-
A
E
V
T
Q
E
N
P
-------------
F
T
V
T
Y
K
I
R
--
P
E
A
Q
W
T
------------
D
N
A
------
P
I
A
A
D
--
D
Y
W
---
Y
L
W
R
Q
M
V
S
Q
P
--------
G
V
V
D
------
P
------
A
---------
G
Y
D
L
I
T
G
V
Q
--
S
V
E
-------------------------------------------
G
G
K
-
Q
A
V
V
T
F
S
Q
-
P
Y
P
A
W
R
E
--------
L
F
N
-------
D
I
L
P
A
-
H
-
I
V
K
D
I
P
G
G
----------
F
G
A
-------------------
G
L
A
R
A
M
P
V
T
---
G
G
Q
F
R
V
E
T
I
D
P
Q
R
D
E
I
L
L
A
R
N
D
R
F
W
S
------
V
P
A
K
P
D
L
V
L
F
R
R
G
G
-
A
P
A
A
L
A
D
S
I
R
N
G
D
T
Q
V
A
Q
-
V
H
G
G
A
-
A
--
T
---
F
A
Q
L
S
A
-
I
-
P
D
V
R
T
A
R
-------
I
V
T
P
R
---
V
M
Q
L
T
L
R
A
-------------
Q
Q
-------
P
K
L
A
D
P
Q
V
R
K
A
I
------
L
G
L
I
D
V
D
L
L
A
-
S
V
G
A
G
D
--
D
N
T
VT
L
A
Q
A
Q
-
V
R
---
S
P
--
S
D
P
G
Y
-----------------
V
PTA------
P
P
-
A
M
T
R
D
D
A
L
E
L
L
R
D
--------
26
HHSearch
56.77
15%
-19
* C5 *
3DRF
1
?
A:
[32-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
N
L
K
V
A
Y
--
Q
S
D
S
P
M
K
A
Q
W
L
--
S
GLS
N
--
D
---
A
T
--
F
A
-
T
-
M
S
G
P
G
G
G
Q
D
G
L
F
F
T
D
S
--
G
--------
F
K
F
I
--
K
G
G
A
--
A
D
-
V
A
L
D
K
-
E
S
-------------
K
T
A
T
I
T
L
R
--
K
D
L
K
W
S
------------
D
G
S
------
E
V
T
A
K
--
D
Y
E
---
F
T
Y
E
T
I
A
N
P
A
--------
Y
G
S
D
R
--
W
--
T
------
D
---------
S
L
A
N
I
V
G
L
S
--
D
Y
H
T
G
------------------
K
A
K
T
I
S
G
I
-
T
F
P
D
G
--------
E
N
G
K
-
V
I
K
V
Q
F
K
E
-
M
K
P
G
M
T
Q
SGNGYFLE
T
V
A
P
Y
-
Q
Y
LK
D
V
A
P
K
-
D
-
L
A
S
S
------------------------------------
P
K
T
T
T
K
P
L
V
---
T
G
P
F
K
P
E
N
V
V
A
G
-
E
S
I
K
Y
V
P
N
P
Y
Y
W
G
------
E
K
P
K
L
N
S
I
T
Y
E
V
V
S
-
T
A
-
K
S
V
A
A
L
S
S
S
K
Y
D
I
I
N
-
G
-
M
V
S
-
S
--
Q
---
Y
K
Q
V
K
N
-
L
-
K
G
Y
K
V
L
G
-------
Q
Q
A
M
Y
---
I
S
L
M
Y
Y
N
L
GHYDAKNSINVQ
D
R
K
-------
T
P
L
Q
D
Q
N
V
R
Q
A
I
------
G
Y
A
R
N
V
A
E
V
D
-
N
K
F
S
N
G
--
L
S
T
--
P
A
-
N
S
-
L
I
---
P
P
--
I
F
K
Q
F
-----------------
T
SSSVK----
G
Y
E
K
Q
D
L
D
K
A
N
K
L
L
D
E
--------
27
HHSearch
56.41
13%
-17
- C5 -
2WOL
3
?
A:
[30-384]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
G
G
T
L
R
L
V
S
--
S
A
D
V
D
S
L
D
P
A
R
--
T
---
Y
--
Y
---
V
W
--
V
W
-
L
-
L
--
Q
R
L
L
N
R
T
L
M
A
Y
P
T
--
D
PGPAG---
L
V
P
A
--
P
D
L
A
--
E
G
P
G
E
V
S
D
-
G
G
-------------
R
T
W
T
Y
R
L
R
--
R
G
L
R
Y
D
------------
D
G
T
------
P
I
T
S
D
--
D
V
R
---
H
A
V
Q
R
V
F
A
Q
D
--------
V
L
P
G
G
--
P
--
T
------
Y
---------
L
I
P
L
L
D
D
P
E
--
R
P
Y
P
G
P
---------------
Y
R
T
D
E
P
L
R
S
V
-
L
T
P
D
-----------
E
H
-
T
I
V
F
R
L
T
R
-
P
F
S
D
F
D
H
--------
L
M
A
Q
P
-
C
A
--
A
P
V
P
R
-
R
-
S
D
T
G
A
------------------------------------
D
Y
G
R
D
P
R
S
---
S
G
P
Y
R
V
A
R
H
E
P
D
-
T
L
L
H
L
E
R
N
P
H
W
D
R
A
T
D
P
-
I
R
P
A
L
P
D
R
V
E
L
T
I
G
L
-
D
V
D
V
L
D
A
R
L
I
A
G
E
F
D
I
N
L
-
E
-
G
R
G
L
Q
--
H
---
A
A
Q
R
R
A
-
T
A
D
E
V
L
R
S
H
-------
T
D
N
P
R
TS
F
L
H
F
V
A
M
Q
P
-------------
H
I
-------
P
P
F
D
N
V
H
V
R
R
A
V
------
Q
Y
A
A
D
K
I
L
L
Q
-
D
A
R
G
G
P
VN
G
G
D
--
L
T
-
T
A
-
L
F
---
P
P
--
T
L
P
A
H
-----------------
Q
DLDLYPTGP
D
L
-
R
G
D
L
D
A
A
R
A
E
L
A
A
--------
48
Fugue
55.71
20%
5
- C3 -
4PG7
9
?
A:
[20-446]
-
H
M
K
K
L
N
I
-----
A
L
L
----------
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
R
Q
Q
I
Q
D
T
L
-----------------------------------------------
N
K
D
I
V
I
K
H
I
L
-----------------------
V
R
D
K
---------
S
K
K
R
P
L
N
I
S
Q
-
Y
H
L
T
E
D
----------------------
V
-
N
E
I
L
N
D
D
S
--
L
D
------------------------
I
I
V
E
V
M
-
G
G
I
E
P
T
V
D
W
L
R
--
T
---
A
--
L
K
N
K
K
H
--
V
I
-
T
-
A
--
N
K
D
L
L
A
V
H
L
K
L
L
E
--
D
--------
L
A
E
E
N
G
V
A
L
K
--
F
E
-
A
S
V
A
G
-
G
P
-------------
N
---------
N
I
S
K
F
M
G
I
L
N
G
---
T
S
N
F
I
L
S
------
K
M
T
K
E
QT
T
F
E
---
E
A
L
D
E
A
K
R
L
G
--------
F
A
E
A
D
--
P
-
T
D
------
D
---------
V
--------------------------
E
G
V
D
A
A
R
K
V
V
I
T
S
Y
L
-
S
F
N
Q
V
I
K
L
N
D
V
K
R
R
G
I
--------------
S
G
V
T
--------
L
T
D
I
N
-
V
A
--
D
Q
L
G
Y
-
K
-
I
K
L
I
G
K
G
I
Y
-
E
N
-----
G
K
V
N
A
-------
S
V
E
P
T
--
L
---
I
D
K
K
H
Q
L
A
A
VED
E
Y
N
A
I
Y
V
I
G
D
-
A
-
V
G
D
T
M
F
Y
G
K
G
A
G
S
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
L
F
F
E
S
-
T
L
P
P
H
F
E
L
K
T
D
K
T
R
E
M
---------------------
E
-
K
-
S
N
F
F
V
V
V
-------
N
H
V
K
G
---
S
I
E
N
F
E
N
E
-------------
L
K
------
A
I
L
P
F
H
R
S
L
R
V
A
N
------
Y
D
---
N
Q
S
Y
A
-
A
-
V
I
V
G
--------
L
-
E
S
-
S
P
---
E
E
--
L
I
T
K
H
-----------------
G
---------
Y
E
-
V
D
K
V
Y
P
V
E
G
V
-----------
7
PsiBlast_PDB
53.18
24%
-11
- C2 -
4XKR
9
?
A:
[178-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
P
K
L
D
H
I
T
V
T
Y
Q
E
-
D
G
N
N
R
V
R
N
L
E
S
Q
K
D
D
L
I
T
-
D
-
V
P
V
-
N
--
K
---
V
Q
D
I
E
N
-
N
-
Q
N
L
K
V
S
K
-------
E
S
G
F
R
---
T
S
L
L
M
Y
N
H
-------------
T
N
------
K
--
K
M
T
K
S
V
R
E
A
L
------
D
H
I
I
D
R
Q
G
I
A
D
H
-
I
Y
Q
G
--
Y
A
K
--
P
A
-
T
S
-
P
F
NDK
I
P
--
Y
I
K
E
P
-----------------
K
---------
L
T
-
K
Q
N
I
E
Q
A
K
-------------
5
PsiBlast_PDB
52.21
24%
-15
- C2 -
4XKP
6
?
A:
[178-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
P
K
L
D
H
I
T
V
T
Y
Q
E
-
D
G
N
N
R
V
R
N
L
E
S
Q
K
D
D
L
I
T
-
D
-
V
P
V
-
N
--
K
---
V
Q
D
I
E
N
-
N
-
Q
N
L
K
V
S
K
-------
E
S
G
F
R
---
T
S
L
L
M
Y
N
H
-------------
T
N
------
K
--
K
M
T
K
S
V
R
E
A
L
------
D
H
I
I
D
R
Q
G
I
A
D
H
-
I
Y
Q
G
--
Y
A
K
--
P
A
-
T
S
-
P
F
NDK
I
P
--
Y
I
K
E
P
-----------------
K
---------
L
T
-
K
Q
N
I
E
Q
A
K
-------------