@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA1427: (2016-03-25 )
MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
Atome Classification :
(61 SA)
.........10..-......20........30........40........50........60........70........80........90........100.......110.......120.......130..-.....-140........150.......160.......170.......180.......190.......200.......210.......220......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIGIIGA
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
SE
I
S
V
A
H
V
K
F
Y
T
G
ILKD
R
E
V
V
I
TQSGIG
K
V
N
A
A
I
S
T
T
L
L
I
NKFKP
D
V
I
I
NTGSAGALDESLNVG
D
V
L
ISDD
V
K
YHDADATAFGYEYGQIPQMPVAFQSSK
P
L
I
E
K
V
S
Q
V
V
Q
Q
-
Q
Q
L
T
A-KV-
G
L
I
V
SG
D
S
F
I
G
S
V
E
Q
R
Q
K
I
K
K
AFPN
A
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
QFNV
P
F
V
V
V
R
A
V
S
D
LANG
E
A
E
M
S
F
E
A
F
L
E
K
AAVSS
S
Q
T
V
E
A
L
V
SQL
2
PsiBlast_PDB
97.54
100%
-112
- C1 -
4GMH
3
MTNN_STAAM
A:
[3-230]
M
I
G
I
I
G
A
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
Q
-
Q
Q
L
T
A
-
K
V
-
G
L
I
V
S
G
D
S
F
I
G
S
V
E
Q
R
Q
K
I
K
K
A
F
P
N
A
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
81
HHSearch
97.03
100%
-107
- C1 -
3BL6
1
MTNN_STAAM
A:
[3-230]
M
I
G
I
I
G
A
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
Q
-
Q
Q
L
T
A
-
K
V
-
G
L
I
V
S
G
D
S
F
I
G
S
V
E
Q
R
Q
K
I
K
K
A
F
P
N
A
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
1
PsiBlast_PDB
97.03
100%
-107
- C1 -
3BL6
1
MTNN_STAAM
A:
[3-230]
M
I
G
I
I
G
A
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
Q
-
Q
Q
L
T
A
-
K
V
-
G
L
I
V
S
G
D
S
F
I
G
S
V
E
Q
R
Q
K
I
K
K
A
F
P
N
A
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
5
PsiBlast_PDB
82.48
52%
-97
- C1 -
4G89
3
MTNN_KLEP7
A:
[8-234]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
T
I
G
G
S
E
I
Y
T
G
Q
L
H
G
V
D
V
A
L
L
K
S
G
I
G
K
V
A
A
A
M
G
A
T
L
L
L
E
R
C
Q
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
E
K
L
V
A
A
A
E
S
C
I
K
A
-
L
D
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
E
E
F
L
A
V
A
A
R
Q
S
T
L
M
V
E
N
L
V
Q
N
L
14
PsiBlast_PDB
81.45
54%
-99
- C1 -
4YML
1
?
A:
[3-229]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
7
PsiBlast_PDB
81.30
53%
-102
- C1 -
4F1W
11
?
A:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
13
PsiBlast_PDB
81.16
54%
-98
- C1 -
4WKC
2
?
A:
[3-229]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
37
PsiBlast_CBE
81.06
54%
-103
- C1 -
1JYS
1
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
41
PsiBlast_CBE
80.99
54%
-99
- C1 -
1Z5O
2
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
39
PsiBlast_CBE
80.80
54%
-99
- C1 -
1Z5N
2
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
Q
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
23
PsiBlast_CBE
80.55
52%
-100
- C1 -
4G89
1
MTNN_KLEP7
B:
[8-234]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
T
I
G
G
S
E
I
Y
T
G
Q
L
H
G
V
D
V
A
L
L
K
S
G
I
G
K
V
A
A
A
M
G
A
T
L
L
L
E
R
C
Q
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
E
K
L
V
A
A
A
E
S
C
I
K
A
-
L
D
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
E
E
F
L
A
V
A
A
R
Q
S
T
L
M
V
E
N
L
V
Q
N
L
20
PsiBlast_PDB
80.46
54%
-107
- C1 -
1Z5P
4
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
11
PsiBlast_PDB
80.42
53%
-98
- C1 -
4F3K
3
?
A:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
26
PsiBlast_CBE
80.33
53%
-99
- C1 -
4F3C
4
?
B:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
16
PsiBlast_PDB
80.31
54%
-99
- C1 -
1NC3
1
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
19
PsiBlast_PDB
80.24
54%
-98
- C1 -
1Y6R
2
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
18
PsiBlast_PDB
80.20
54%
-96
- C1 -
1Y6Q
3
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
40
PsiBlast_CBE
80.19
54%
-100
- C1 -
1Z5O
2
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
17
PsiBlast_PDB
80.16
54%
-99
- C1 -
1NC1
1
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
10
PsiBlast_PDB
80.13
53%
-98
- C1 -
4F3C
4
?
A:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
33
PsiBlast_CBE
79.99
54%
-99
- C1 -
1Y6R
2
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
27
PsiBlast_CBE
79.88
53%
-98
- C1 -
4F2W
7
?
B:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
29
PsiBlast_CBE
79.80
53%
-98
- C1 -
4F1W
8
?
B:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
28
PsiBlast_CBE
79.73
53%
-98
- C1 -
4F2P
4
?
B:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
31
PsiBlast_CBE
79.68
54%
-99
- C1 -
3DF9
2
MTNN_ECO57
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
34
PsiBlast_CBE
79.46
54%
-98
- C1 -
1Y6Q
3
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
36
PsiBlast_CBE
79.36
54%
-97
- C1 -
1NC1
1
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
32
PsiBlast_CBE
79.33
54%
-99
- C1 -
3DF9
2
MTNN_ECO57
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
38
PsiBlast_CBE
79.21
54%
-99
- C1 -
1Z5N
3
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
Q
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
35
PsiBlast_CBE
79.18
54%
-97
- C1 -
1NC3
1
MTNN_ECOLI
B:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
15
PsiBlast_PDB
79.04
54%
-103
- C1 -
1JYS
1
MTNN_ECOLI
A:
[13-239]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
22
PsiBlast_CBE
79.00
53%
-93
- C1 -
3DP9
3
MTNN_VIBCH
C:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
V
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
25
PsiBlast_CBE
78.82
53%
-97
- C1 -
4F3K
4
?
B:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
9
PsiBlast_PDB
78.79
53%
-96
- C1 -
4F2W
5
?
A:
[19-245]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
D
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
30
PsiBlast_CBE
78.72
54%
-99
- C1 -
3O4V
7
MTNN_ECOLI
B:
[5-231]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
82
HHSearch
78.59
46%
-95
* C1 *
3EEI
2
?
A:
[5-233]
T
V
A
V
I
G
A
M
E
Q
E
I
E
-
L
L
R
E
M
M
E
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
A
A
R
T
F
E
G
A
A
V
-
E
Q
-
G
L
I
V
S
G
D
R
F
V
H
S
S
E
G
V
A
E
I
R
K
H
F
P
E
V
K
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
M
V
A
E
I
V
K
S
L
12
PsiBlast_PDB
78.57
54%
-98
- C1 -
3O4V
5
MTNN_ECOLI
A:
[5-231]
-
I
G
I
I
G
A
M
E
E
E
V
T
-
L
L
R
D
K
I
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
E
-
L
N
L
N
A
-
V
R
-
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
6
PsiBlast_PDB
78.45
53%
-93
- C1 -
4WKB
2
?
A:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
V
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
3
PsiBlast_PDB
77.89
54%
-91
- C1 -
4X24
3
?
A:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
P
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
I
C
T
A
E
G
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
24
PsiBlast_CBE
77.77
53%
-88
- C1 -
4WKB
2
?
B:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
V
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
21
PsiBlast_CBE
77.62
54%
-91
- C1 -
4X24
2
?
B:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
P
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
I
C
T
A
E
G
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
45
PsiBlast_CBE
77.51
46%
-95
- C1 -
3EEI
2
?
B:
[6-233]
-
V
A
V
I
G
A
M
E
Q
E
I
E
-
L
L
R
E
M
M
E
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
A
A
R
T
-
F
E
G
A
A
V
E
Q
-
G
L
I
V
S
G
D
R
F
V
H
S
S
E
G
V
A
E
I
R
K
H
F
P
E
V
K
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
M
V
A
E
I
V
K
S
L
4
PsiBlast_PDB
77.33
53%
-91
- C1 -
3DP9
2
MTNN_VIBCH
A:
[3-230]
-
I
G
I
I
G
A
M
Q
Q
E
V
A
-
I
L
K
D
L
I
E
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
Q
-
L
P
N
T
H
-
A
V
R
G
L
I
C
T
G
D
A
F
V
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
46
PsiBlast_CBE
76.92
46%
-93
- C1 -
3EEI
2
?
A:
[6-233]
-
V
A
V
I
G
A
M
E
Q
E
I
E
-
L
L
R
E
M
M
E
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
A
A
R
T
-
F
E
G
A
A
V
E
Q
-
G
L
I
V
S
G
D
R
F
V
H
S
S
E
G
V
A
E
I
R
K
H
F
P
E
V
K
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
M
V
A
E
I
V
K
S
L
53
PsiBlast_CBE
74.65
43%
-94
- C1 -
3MMS
3
?
A:
[3-229]
-
I
G
I
I
A
A
M
P
E
E
L
A
-
Y
L
V
Q
H
L
D
N
A
Q
E
Q
V
V
L
G
N
T
Y
H
T
G
T
I
V
S
H
E
V
V
L
V
E
S
G
I
G
K
V
M
S
A
M
S
V
A
I
L
A
V
H
F
Q
V
D
A
L
I
N
T
G
S
A
G
A
V
A
E
G
I
A
V
G
D
V
V
I
A
D
K
L
A
Y
H
D
V
D
V
T
A
F
G
Y
A
Y
G
Q
M
A
Q
Q
P
L
Y
F
E
S
D
K
T
F
V
A
Q
I
Q
E
S
L
-----
Q
N
W
-
H
L
-
G
L
I
A
T
G
D
S
F
V
A
G
N
D
K
I
E
A
I
K
S
H
F
P
E
V
L
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
A
L
N
L
P
V
L
V
I
R
A
M
S
D
N
A
N
H
E
A
N
I
F
F
D
E
F
I
I
E
A
G
R
R
S
A
Q
V
L
L
A
F
L
K
A
L
43
PsiBlast_CBE
74.24
48%
-89
- C1 -
4QEZ
2
MTNN_BACAN
B:
[3-223]
-
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
-----
Q
V
-
V
K
-
G
M
I
A
T
G
D
S
F
M
S
D
P
N
R
V
A
A
I
R
D
K
F
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
-------
54
PsiBlast_CBE
73.74
41%
-95
- C1 -
4G41
1
?
B:
[8-234]
-
I
G
I
I
A
A
M
E
E
E
L
S
-
L
L
L
A
N
L
L
D
A
Q
E
H
Q
V
L
S
K
T
Y
Y
T
G
R
F
G
K
H
E
L
I
L
V
Q
S
G
V
G
K
V
M
S
A
M
T
V
A
I
L
V
E
H
F
K
A
Q
A
I
I
N
T
G
S
A
G
A
V
A
S
H
L
A
I
G
D
V
V
V
A
D
R
L
V
Y
H
D
V
D
A
T
A
F
G
Y
A
Y
G
Q
M
A
G
Q
P
L
Y
Y
D
C
D
P
Q
F
V
A
I
F
K
Q
V
L
K
H
-
E
K
T
N
G
-
Q
V
-
G
L
I
A
T
G
D
S
F
V
A
G
Q
D
K
I
D
Q
I
K
T
A
F
S
N
V
L
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
A
G
K
P
F
I
V
V
R
A
M
S
D
T
A
A
H
D
A
N
I
T
F
D
Q
F
I
I
E
A
G
K
R
S
A
Q
I
L
M
T
F
L
E
N
L
44
PsiBlast_CBE
73.19
48%
-88
- C1 -
4QEZ
2
MTNN_BACAN
A:
[3-223]
-
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
------
V
-
V
K
-
G
M
I
A
T
G
D
S
F
M
S
D
P
N
R
V
A
A
I
R
D
K
F
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
-------
42
PsiBlast_CBE
72.44
48%
-90
- C1 -
4QEZ
2
MTNN_BACAN
C:
[3-223]
-
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
-----
Q
V
-
V
K
-
G
M
I
A
T
G
D
S
F
M
S
D
P
N
R
V
A
A
I
R
D
K
F
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
F
I
-------
58
PsiBlast_CBE
70.90
36%
-93
- C1 -
4BMZ
2
MQMTN_HELPY
B:
[25-251]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
V
A
N
E
-
Q
H
I
V
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
F
L
K
S
M
V
D
E
L
56
PsiBlast_CBE
70.79
36%
-92
- C1 -
4BMX
2
MQMTN_HELPY
B:
[25-251]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
V
A
N
E
-
Q
H
I
V
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
F
L
K
S
M
V
D
E
L
69
PsiBlast_CBE
70.75
35%
-95
- C1 -
4OY3
2
MQMTN_HELPJ
A:
[5-231]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
59
PsiBlast_CBE
70.65
36%
-93
- C1 -
4BMZ
2
MQMTN_HELPY
A:
[25-251]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
V
A
N
E
-
Q
H
I
V
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
F
L
K
S
M
V
D
E
L
67
PsiBlast_CBE
70.55
35%
-94
- C1 -
4FFS
2
MQMTN_HELPJ
A:
[13-239]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
62
PsiBlast_CBE
70.42
35%
-92
- C1 -
3NM5
2
MQMTN_HELPJ
B:
[4-230]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
61
PsiBlast_CBE
70.29
35%
-93
- C1 -
3NM6
6
MQMTN_HELPJ
B:
[4-230]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
68
PsiBlast_CBE
69.70
35%
-95
- C1 -
4P54
2
MQMTN_HELPJ
A:
[5-231]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
63
PsiBlast_CBE
69.54
35%
-92
- C1 -
3NM5
2
MQMTN_HELPJ
A:
[4-230]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
66
PsiBlast_CBE
69.46
35%
-93
- C1 -
4OJT
2
MQMTN_HELPJ
A:
[5-231]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
65
PsiBlast_CBE
69.25
35%
-93
- C1 -
3NM4
4
MQMTN_HELPJ
A:
[4-230]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
64
PsiBlast_CBE
68.10
35%
-100
- C1 -
3NM4
4
MQMTN_HELPJ
B:
[4-230]
-
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
E
-
Q
H
I
A
L
-
K
E
-
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
-------
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L