@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0664: (2015-12-17 )
MDFKNKKWLFLAPLAGYTDLPFRSVVKKFGVDVTTSEMVSSHSLVYAFDKTSKMLEKSPLEDHFMAQISGSKESVVKEAVEKINALDHVSGIDFNCGCPAPKVANHGNGSGLLKDLNHLVEILKVIRENTNKKITSVKVRLGFEKKIPKEIAHALNDAPVDYVVVHGRTRSDRYQKDKIDYESIALMKKILKKPVIANGEIDSVKKAFEVLQITQADGLMIGRATLRAPWIFWQIRNNTTELPAVVKKDLVLEHFDKMVEFYGDRGVIMFRKNLHAYAKGEMQASAFRNCVNTLTEIKSMRESIEEFFNQEMLQSEVPLWVELNQKSV
Atome Classification :
(20 SA)
.........10......--------.-----.20-------.......--.-30...-..-..---..---40.....-------------------.---------.-----------.---------------------50.-...---.---.----..60........70-----------------------.-----------------------.----------------------......80........-90......---------.---------.100.......110.......120.......130-...-.....140-----...------.----.----...-150.---......160.......----------------170-----------------.----------------.--...---.-.---..180.......190-..-......200.......210.......220.....-..230...----....240---.----........250.......260-----..-.-....270.......280.......290.......300.......310.......320......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDFKN
K
K
W
L
F
LAPLAGY--------T-----DL
P
-------
F
R
S
V
V
K
K
--F-G-VDV-
T
T
-
S
E
---MV---SSH
S
L
V
Y
-------------------
A
---------F-----------D---------------------
K
T
S
-
K
M
L
---
E
---K----SPL
E
D
H
F
M
A
Q
ISG
S
-----------------------
K
-----------------------
E
----------------------
S
V
V
K
E
A
V
E
K
I
N
A
LDHV-SGIDFNCG---------C---------PAPKVANHGNGS
G
L
L
K
D
L
N
H
L
V
E
I
L
K
V
I
R
ENTN--K
K
I
-
T
S
V
K
V
R
L------GFE------K----K----
I
P
K
-
E
I
A
H
---
A
LNDAPV
D
Y
V
V
VHGRT----------------R-------------------S----------------D--RYQ---K-D---KI
D
Y
E
S
I
A
L
M
K
K
I
L
--KK-PVIANG
E
I
D
S
V
K
K
A
F
E
V
L
QITQAD
G
L
M
I
G
R
A
T
LR-A
P
W
I
F
W
Q
I----RNNTT-----E----
L
P
A
V
V
K
K
D
L
V
L
E
H
F
D
K
M
V
E
F
Y-----GD-R-
G
V
I
M
F
RKNL
H
A
YAKG
E
M
Q
A
S
A
F
R
N
C
V
N
T
L
T
E
I
K
S
M
R
E
S
I
E
E
F
F
N
Q
E
M
L
Q
SEV
P
L
W
V
ELNQKSV
1
PsiBlast_PDB
96.56
32%
-88
- C2 -
1VHN
4
?
A:
[9-307]
----------
L
A
P
M
A
G
Y
--------
T
-----
D
S
A
-------
F
R
T
L
A
F
E
--
W
-
G
-
A
D
F
-
A
F
-
S
E
---
M
V
---
S
A
K
G
F
L
M
-------------------
N
---------
S
-----------
Q
---------------------
K
T
E
-
E
L
L
---
P
---
Q
-----
P
H
E
R
N
V
A
V
Q
I
F
G
S
-----------------------
E
-----------------------
P
----------------------
N
E
L
S
E
A
A
R
I
L
S
--
E
K
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
S
--
G
K
F
--
S
V
K
T
R
L
------
G
W
E
------
K
----
N
----
E
V
E
-
E
I
Y
R
---
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
----------------
V
-------------------
V
----------------
Q
--
S
F
T
-----
G
---
R
A
E
W
K
A
L
S
V
L
E
K
R
I
-----
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
F
L
R
S
G
K
Y
-----
S
----
E
P
S
---
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K-
G
E
-
R
K
A
V
V
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
E
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
----------------
25
HHSearch
93.41
31%
-73
- C2 -
1VHN
4
?
A:
[5-309]
------
V
K
V
G
L
A
P
M
A
G
Y
--------
T
-----
D
S
A
-------
F
R
T
L
A
F
E
--
W
-
G
-
A
D
F
-
A
F
-
S
E
---
M
V
---
S
A
K
G
F
L
M
-------------------
N
---------
S
-----------
Q
---------------------
K
-
T
-
E
E
L
---
L
---
P
----
Q
P
H
E
R
N
V
A
V
Q
I
F
G
S
-----------------------
E
-----------------------
P
----------------------
N
E
L
S
E
A
A
R
I
L
-
S
E
-
K
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
S
--
G
K
--
F
S
V
K
T
R
L
------
G
W
E
------
K
----
N
----
E
V
E
-
E
I
Y
R
---
I
L
V
E
E
G
V
D
E
V
F
I
H
T
R
T
----------------
V
-------------------
V
----------------
Q
--
S
F
T
---
G
-----
R
A
E
W
K
A
L
S
V
L
E
K
----
R
I
-
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
----
K
D
F
L
R
SG
K
Y
S
E
----
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
-----
G
E
R
K
-
A
V
V
E
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
I
E
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
----------------
49
Fugue
86.14
28%
-72
- C2 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
----
A
S
M
R
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
N
D
-
Y
D
L
-
C
I
-
T
E
---
F
V
RVV
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
S-----
G
----
E
----
K
K
F
-
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
----
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
GDT
G
L
-
Y
-
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
L
----------------
50
Fugue
80.14
25%
-86
- C2 -
3B0P
1
DUSAL_THET8
A:
[2-318]
L
D
P
R
----
L
S
V
A
P
M
V
D
R
--------
T
-----
D
R
H
-------
F
R
F
L
V
R
Q
--
V
-
S
-
L
G
V
-
R
L
Y
T
E
---
M
T
---
V
D
Q
A
V
L
R
-----------------------------------------
G
---------------------
N
R
E
-
R
L
L
---
A
---
F
----
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
-----------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
--
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
R
--
V
P
V
-
T
-
V
K
M
R
L
------
G
L
E
------
G
KET
Y
R
----
G
L
A
-
Q
S
V
E
---
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
---------------------------------------------------------
S
A
L
---
I
-
P
---
P
L
R
H
D
W
V
H
R
L
K
G
D
F
--
P
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
----
D
R
R
V
F
-----
G
----
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
-----
V
L
-
K
-
G
T
P
P
W
A
V
L
R
H
-----------
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
L
Q
A
L
D
R
A
L
R
L
M
E
E
E
V
G
E
--
26
HHSearch
75.75
22%
-72
- C2 -
3B0P
1
DUSAL_THET8
A:
[2-318]
----
L
D
P
R
L
S
V
A
P
M
V
D
R
--------
T
-----
D
R
H
-------
F
R
F
L
V
R
Q
--
V
-
S
-
L
G
V
R
L
Y
-
T
E
---
M
T
---
V
D
Q
A
V
L
R
-------------------
G
---------
N
-----------
R
---------------------
E
---
R
L
L
---
A
---
F
----
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
-----------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
-
E
A
F
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
R
--
V
P
--
V
T
V
K
M
R
L
------
G
L
E
------
G
----
K
ET
Y
R
G
L
A
-
Q
S
V
E
---
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
----------------
A
-------------------
L
--------------------------I
P
---
P
L
R
H
D
W
V
H
R
L
K
G
D
F
P-
Q
L
-
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
----
D
R
R
V
F
-----
G
LP
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
--------
T
-
P
P
W
A
V
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
L
Q
A
L
D
R
A
L
R
L
M
E
E
E
V
G
E
---------------
21
PsiBlast_CBE
74.99
31%
-78
- C2 -
4BFA
6
DUSC_ECOLI
B:
[26-268]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
----------------------------
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
L
---------------
3
PsiBlast_PDB
73.85
31%
-76
- C2 -
4BFA
5
DUSC_ECOLI
A:
[26-268]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
L
---------------
2
PsiBlast_PDB
73.14
31%
-81
- C2 -
3W9Z
1
DUSC_ECOLI
A:
[3-245]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
C
----------------------
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
H
V
A
R
-----
I
K
-
Q
-
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
---------------------------
23
PsiBlast_CBE
73.07
31%
-76
- C2 -
4YCO
1
DUSC_ECOLI
B:
[9-251]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
------------------
5
PsiBlast_PDB
72.81
31%
-71
- C2 -
4YCP
2
DUSC_ECOLI
A:
[9-251]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
A
---------
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
L
---------------
22
PsiBlast_CBE
72.76
31%
-76
- C2 -
4YCO
1
DUSC_ECOLI
C:
[9-251]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
----------------
4
PsiBlast_PDB
72.20
31%
-73
- C2 -
4YCO
1
DUSC_ECOLI
A:
[9-251]
--------
V
L
L
A
P
M
E
G
V
--------
L
-----
D
S
L
-------
V
R
E
L
L
T
E
--
V
-
N
D
Y
D
L
-
C
I
-
T
E
FVR
V
V
---
D
Q
L
L
P
V
K
-------------------
V
---------
F
-----------
H
---------------------
R
I
C
-
P
E
L
---
Q
NAS
R
----
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
-----------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
--
W
G
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
----------------
7
PsiBlast_PDB
69.77
27%
-78
- C2 -
3B0P
1
DUSAL_THET8
A:
[6-246]
--------
L
S
V
A
P
M
V
D
R
--------
T
-----
D
R
H
-------
F
R
F
L
V
R
Q
--
V
-
S
-
L
G
V
-
R
L
Y
T
E
---
M
T
---
V
D
Q
A
V
L
R
-------------------
G
-------------------------------------------
N
R
E
-
R
L
L
---
A
---
F
----
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
-----------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
--
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
R
--
V
P
V
-
T
-
V
K
M
R
L
------
G
L
E
G-----
K
----
E
----
T
Y
R
-
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
ALIPPL----------
R
-------------------
H
----------------
D
--
W
V
H
---
R
-
L
---
K
G
D
F
P
Q
L
T
F
------------
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
----
D
R
R
V
F
-----
G
----
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
-----
V
L
-
K
-
G
T
P
P
W
A
V
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
L
Q
A
L
D
R
A
L
R
L
M
E
E
E
V
G
E
-------------
10
PsiBlast_PDB
67.46
28%
-73
- C2 -
3B0V
1
DUSAL_THET8
C:
[27-267]
--------
L
S
V
A
P
M
V
D
R
--------
T
-----
D
R
H
-------
F
R
F
L
V
R
Q
VS
L
-
G
-
V
R
L
-
Y
T
-
E
M
---
T
V
---
D
Q
A
V
L
-------------------------------
R
-----------
G
---------------------
N
R
E
-
R
L
L
---
A
---
F
----
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
-----------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
--
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
R
--
V
P
V
-
T
-
V
K
M
R
L
------
G
L
E
G-----
K
----
E
----
T
Y
R
-
G
L
A
Q
SVE
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
ALLALSTKANREIPPL
R
-------------------
H
----------------
D
--
W
V
H
---
R
-
L
---
K
G
D
F
P
Q
L
T
F
------------
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
----
D
R
R
V
F
-----
G
----
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
-----
V
L
-
K
-
G
T
P
P
W
A
V
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
L
Q
A
L
D
R
A
L
R
L
M
E
E
E
----------------
42
HHSearch
65.97
19%
-65
- C2 -
1JUB
6
PYRDA_LACLM
A:
[7-289]
A
N
A
K
F
A
N
P
F
M
N
A
S
G
V
H
C
--------
M
-----
T
I
E
-------
D
L
E
E
L
K
A
--
S
-
Q
-
A
G
A
-
Y
I
-
T
K
---
S
S
---
T
L
E
K
R
E
G
-------------------
N
---------
P
L----------
P
R
Y
V
D
L
EL
G
S
I
N
SMGLPNLG
F
D
Y
Y
L
-
D
Y
V
---
L
---
K
N
Q
K
E
N
A
Q
E
G
P
I
F
F
S
I
A
G
M
-----------------------
S
-----------------------
A
----------------------
A
E
N
I
A
M
L
K
K
I
-
Q
E
S
D
F
S
G
I
T
E
L
N
L
S
---------
C
---------
P
N
V
P
G
E
-----
P
Q
L
A
Y
D
F
E
A
T
E
K
L
L
K
E
V
F
T
F
F
T
--
K
P
--
L
G
V
K
L
P
P
------
Y
F
D
------
L
----
V
----
H
F
D
-
I
M
A
E
---
I
L
N
Q
F
P
L
T
Y
V
N
S
V
N
S
I
----------------
G
N
G
L
F
I
DPEAESVVIKPKDG
F
----------------
G
--
G
I
G
---
G
-
A
YI
K
P
T
A
L
A
N
V
R
A
F
Y
T
R
L
KP
E
I
-
Q
I
I
G
T
G
G
I
E
T
G
Q
D
A
F
E
H
L
L
-
C
G
A
T
M
L
Q
I
G
T
A
L
H
K
E
G
P
A
I
F
D
R
I
----
I
K
E
L
E
-----
E
----
I
M
N
Q
K
G
Y
Q
S
I
A
D
F
H
G
K
L
K
S
L
--------------------------------------------------------------------------
6
PsiBlast_PDB
62.42
38%
-86
- C2 -
4BF9
1
DUSC_ECOLI
A:
[114-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
P
--
A
H
L
P
V
S
V
K
V
R
L
------
G
W
D
------
S
----
G
----
E
K
K
F
E
I
A
D
---
A
V
Q
Q
A
G
A
T
E
L
V
V
H
G
R
T
----------------
K
-------------------
E
----------------
Q
--
G
Y
R
---
A
-
E
---
H
I
D
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
-
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
----
K
Y
N
E
P
-----
R
----
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
-----
T
G
-
L
-
Y
H
V
A
R
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
L
N
N
S
P
D
I
A
R
A
I
Q
A
I
D
I
E
K
L
---------------
8
PsiBlast_PDB
61.14
27%
-56
- C2 -
3B0U
3
DUSAL_THET8
X:
[6-246]
--------
L
S
V
A
P
M
V
D
R
--------
T
-----
D
R
H
-------
F
R
F
L
V
R
Q
--
V
-
S
-
L
G
V
-
R
L
Y
T
E
---
M
T
---
V
D
Q
A
V
L
R
-------------------
G
-------------------------------------------
N
R
E
-
R
L
L
---
A
---
F
----
R
P
E
E
H
P
I
A
L
Q
L
A
G
S
-----------------------
D
-----------------------
P
----------------------
K
S
L
A
E
A
A
R
I
G
E
A
F
G
Y
--
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
R
--
V
P
V
-
T
-
V
K
M
R
L
------
G
L
E
G-----
K
----
E
----
T
Y
R
-
G
L
A
Q
SVE
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
S
ALLALSTKANREIPPL
R
-------------------
H
----------------
D
--
W
V
H
---
R
-
L
---
K
G
D
F
P
Q
L
T
F
------------
V
T
N
G
G
I
R
S
L
E
E
A
--
L
F
H
L
K
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
----
D
R
R
V
F
-----
G
----
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
-----
V
L
-
K
-
G
T
P
P
W
A
V
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
L
Q
A
L
D
R
A
L
R
L
M
E
------------------
30
HHSearch
59.78
18%
-70
- C2 -
3HGJ
2
?
A:
[11-336]
G
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
Y
SATLEGEV
T
-----
D
W
H
L
L
H
----
Y
P
T
R
A
L
---
G
-
G
-
V
G
L
-
I
L
-
V
E
---
A
T
---
A
V
E
P
L
G
R
-------------------
I
---------
S
PYDLGIWSEDH
L
---------------------
P
G
L
-
K
E
L
---
A
---
R
R
I
--
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
-----------------------
G
RKAGTARPWEGGKPLGWRVVGPS
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
-
L
R
A
G
F
-
Q
V
I
E
L
H
M
A
---------
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
P
RE
L
P
--
L
F
V
R
V
S
A
TDWGEG
G
W
S
------
L
----
E
----
D
T
L
-
A
F
A
R
---
R
L
K
E
L
G
V
D
L
L
D
C
S
S
G
G
----------------
V
-------------------
V
----------------
L
--
R
V
R
IPL
A
-
P
---
G
F
Q
V
P
F
A
D
A
V
R
K
R
V
--
G
L
-
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
-
D
P
Y
F
P
L
R
A
----
A
K
A
L
G
-----
V
----
A
P
E
V
P
P
Q
Y
Q
R
G
F
----------------------------------------------------------------------------------
28
HHSearch
59.23
16%
-65
- C2 -
3GR7
3
NAMA_GEOKA
A:
[12-325]
R
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
--------
S
CDTKD
G
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
V
---
G
-
Q
-
V
G
L
-
I
I
-
V
E
---
A
T
---
G
V
T
P
Q
G
R
-------------------
I
SERDLGIWS
D
DH---------
I
---------------------
A
G
L
-
R
E
L
---
V
---
G
L
V
--
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
GRKSQVP
G
E
I
I
A
PSAVPFDDSSP
T
-----------------------
P
KEMT
K
A
D
I
E
E
T
V
----------
Q
A
F
Q
N
G
A
R
R
A
-
K
E
A
G
F
-
D
V
I
E
I
H
A
A
HGY
L
I
N
E
F
L
S
---------
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
W
D
--
G
P
--
L
F
V
R
I
S
A
------
S
D
Y
HPDGLT
A
----
K
----
D
Y
V
-
P
Y
A
K
---
R
M
K
E
Q
G
V
D
L
V
D
V
S
S
G
A
----------------
I
-------------------
V
----------------
P
A
R
M
N
V
---
Y
-
P
---
G
Y
Q
V
P
F
A
E
L
I
R
R
E
A
--
D
I
-
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
-
N
P
Y
W
P
Y
A
A
----
A
R
E
L
G
-----
A
----
K
I
S
A
P
V
Q
Y
E
R
G
W
R
F
--------------------------------------------------------------------------------
46
HHSearch
55.98
16%
-64
- C2 -
1EP3
2
PYRDB_LACLM
A:
[12-287]
P
G
L
D
L
K
N
P
I
I
P
A
S
G
C
F
G
--------
F
-----
G
E
E
-------
Y
A
K
Y
Y
D
L
--
N
-
K
-
L
G
S
-
I
M
-
V
K
---
A
T
---
T
L
H
P
R
F
G
NPTPR
V
A
E
T
AS
G
M
L
N
AIGL
Q
---------
N
PG
L
--------
E
---------------------
V
I
M
T
E
K
L
P
W
L
N
---
E
----
N
F
P
E
L
P
I
I
A
N
V
A
G
S
-----------------------
E
-----------------------
E
----------------------
A
D
Y
V
A
V
C
A
K
I
G
D
A
A
N
V
-
K
A
I
E
L
N
I
S
---------
C
---------
P
N
V
K
----
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
K
--
V
P
--
L
Y
V
K
L
S
P
------
N
V
T
----------------
D
I
V
-
P
I
A
K
---
A
V
E
A
A
G
A
D
G
L
T
M
I
N
T
L
----------------
M
-------------------
G
V
R
F
D
LKTRQPILANI
T
G
--
G
L
S
---
G
-
P
AI
K
P
V
A
L
K
L
I
H
Q
V
A
Q
D
V
--
D
I
-
P
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
-
A
G
A
S
A
V
A
V
G
T
A
N
F
A
-
D
P
F
V
C
P
K
I
----
I
D
K
L
P
-----
E
----
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
-----
K
-------------------------------------------------------------------