@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1012: (2015-12-20 )
MQTLFKEITSKCYVNGNEMKENSSNVLDQYFTKPSVALKCFQKACEVIKKYENPDDFIFLEPSAGDGVFYDLFPKDRRIGIDIEPKRDGFIQCDFLNYKLPVHQKVICLGNPPFGHRGVMALEFINHARNCDFVCFILPMFFESQGKGSIKYRVKGLNLLYSERLEKNAFIDFKNKEVDVHCVFQIWSKKYQNKKSEFSWYKNRHKEPFSEYIKVFTVSLAKNRECGKEWIFNQKASFYISSTFYKSTQIVENFEEVKYQSGIAVVFTSADKVLNAKLKKLFQEIDWTKYASLATNSCYHLGKSHIFQALHDHLDSLKGN
Atome Classification :
(20 SA)
.........10-------........20---.--....--------...-30-........---40........50....----------------....60...---.....70------------------....----------------------------------------------.---------...80.....---------..---------------------.----------------90-----.......------------------------..100.----.-----...----------....110....-------------..----------------------------.----------------------------120......-.----130------..--.......140----.-.----.-------.----..-..150...-....160.....-..170---------.-......180.......190---.........200..------------.....210.......220..-.....230..---..---------...240...--....250.-.......-260....----...270...-------------....280....------------------..-------.290..-.....300....-...310.......320----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
T
L
F
K
E
I
T
S
K
-------
C
Y
VNGNEMKE---
N
--
S
S
N
V
--------
L
D
Q
-YF-TK
P
S
V
A
L
K
---
C
F
Q
K
A
C
E
V
I
K
KYENPD----------------
D
F
I
F
LEPSA---GDG
V
F
Y
D------------------LFPK----------------------------------------------D---------
R
R
I
G
I
D
IEPK---------RD---------------------
G
----------------
F
------
I
Q
C
D
FLN------------------------YKL--P----V-----
H
Q
K
----------
V
I
C
LGNPPFGH-------------R
G
----------------------------
V
----------------------------
M
A
L
E
F
I
N
HA-R----N--------C
D
--
F
V
C
F
I
L
P
M
-
F
----
F
-E----S-------Q----GK-
G
S
I
K
Y
R
VK-G
L
N
L
L
Y
S
E
RLEK-N
A
F
I
D
---------F-KNK
E
V
D
V
H
C
V
F
Q
I
W
S
K
K
-----YQNKK
S
E
F
S
W
Y
K
N
R------------HKE
P
F
S
E
Y
I
K
V
F
T
V
S
LAKN
R
-
E
C
G
K
E
WIFNQ---K
A
---------
S
F
Y
I
S
STFY--K
S
T
Q
I
-
V
E
-
N
F
E
E
V
K
Y-QS
G
I
A
V
V
----FTS
A
D
K
V
L
N
-------------
A
K
L
K
K
L
F
Q
EI
D
------------------
W
T
-------
K
Y
A
S
L
A
-
T
N
S
C
Y
H
L
G
K
S
H
I
-
F
Q
A
L
H
D
H
L
D
S
LKGN------------------
35
HHSearch
76.45
23%
-127
- C4 -
2IH2
5
MTTA_THEAQ
A:
[21-213]
--------------------------------------------------
V
E
-
T
P
P
E
V
V
D
F
---
M
V
S
L
A
E
A
P
-------
R
----------------
G
G
R
V
L
E
P
A
C
---
A
H
G
P
F
L
R
------------------
A
F
R
E
----------------------------------------------
A
HGTA
Y
----
R
F
V
G
V
E
I
D
P
K
---------
A
L
D
L
P
PW
A
---------------
E
----------------
G
------
I
L
A
D
F
L
L
------------------------
W
E
P
-------
G
-----
E
A
F
----------
D
L
I
L
G
N
P
P
Y
G
I
-------------
V
G
EASKYP
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
STWKGKY
N
----------------------------
L
Y
G
A
F
L
E
K
A
-
V
R
L
LK
P
--------
G
G
--
V
L
V
F
V
V
P
A
-
T
----
W
-
L
----
V
L------
E
----
D
F
-
A
L
L
R
E
F
L
A
R
E
G
K
-
T
S
V
Y
Y
L
G
--
E
V
F
P
---------------
Q
K
K
V
S
A
V
V
I
R
F
Q
K
S
-----
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
------------
G
F
T
P
I
L
W
A
E
Y
P
H
W
E
G
E
I
I
R
F
-
E
T
E
E
T
R
K
L
E
I
---
S
G
---------
M
P
L
G
D
L
F
H
I
--
R
F
A
A
R
-
S
P
-
E
F
K
K
H
P
A
-
V
R
K
E
P
G
P
----
G
L
V
P
V
L
T
G
R
-------------
N
L
K
P
G
W
V
D
Y
E
K
------------------
N
H
-------
S
G
L
W
M
P
-
K
E
R
A
K
E
L
R
D
F
Y
A
-
T
P
H
L
V
V
A
H
T
K
G
T
R
V
------------------
58
Fugue
73.28
21%
-54
- C3 -
4FS7
2
?
A:
[2-394]
Y
D
F
V
I
D
E
I
T
Y
N
F
T
KEHGT
V
E
V
S
G
L
R
E
F
L
---
N
--
P
L
V
V
N
I
P
P
V
V
T
Y
K
D
N
-
K
Y
-
D
V
V
S
I
G
Y
A
---
A
F
Q
G
-
C
R
K
V
T
E
I
K
I
P
S
TVREIGEFAFENCSKL
E
I
I
N
I
P
D
S
V
KMI
G
R
C
T
F
S
G
CYALK
S
I
-----------
L
L
P
L
M---------------------------------------------
L
---------
K
S
I
G
V
E
------------------------------------
A
----------------
F
------
K
G
C
D
F
K
E
------------------------
I
T
I
--
P
-----------
E
G
----------
V
T
V
I
G
D
E
A
F
A
---------------
T
----------------------------
C
----------------------------
E
S
L
E
Y
V
S
L
P
-
D
----
S
M-------
E
------
T
L
H
N
G
-
L
----
F
-
S
----
G
-------
C
----
G
K
L
K
S
I
K
L
-
P
R
-
N
L
K
I
I
R
D
Y
C
F
A
E
-
C
I
L
L
E
---------
N
M
E
F
P
N
S
L
Y
Y
L
G
D
F
A
L
S
K
T
-----
G
V
K
N
I
I
I
P
D
S
F
T
E
L
------------
G
K
S
V
F
Y
G
C
T
D
L
E
S
I
S
I
Q
N
N
K
L
R
I
G
G
S
L
F
Y
N
C
SGL
K
K
---------
V
I
Y
G
S
V
I
V
P
--
E
K
T
F
Y
G
C
S
-
S
L
T
E
V
K
L
-
L
D
S
V
K
F
I
GEEA
F
E
S
C
T
S
L
V
S
-------------
I
D
L
P
Y
L
V
E
E
I
G
KRSFRGCTSLS
N
I
N
F
P
LS
L
R
-------
K
I
G
A
N
A
-
F
Q
G
C
I
N
L
K
K
V
E
L
-
P
K
R
L
E
Q
Y
R
Y
D
F
E
D
T
T
K
F
K
W
I
K-----------
34
HHSearch
68.60
15%
-105
- C4 -
2F8L
7
?
A:
[103-308]
------------------------------------
I
Q
--------
V
N
H
-
Q
M
-
T
P
D
S
I
G
F
I
---
V
A
Y
L
L
E
K
V
I
Q
---
K
K
K
----------------
N
V
S
I
L
D
P
A
C
---
G
T
A
N
L
L
T
------------------
T
V
I
N
----------------------------------------------
Q
L
E
LKGDVDV
H
A
S
G
V
D
V
D
D
L
---------
L
I
S
L
A
L
V
G
A
D
L
Q
RQK
M
-------
T
----------------
L
------
L
H
Q
D
G
L
A
------------------------
N
L
L
-------
V
-----
D
P
V
----------
D
V
V
I
S
D
L
P
V
G
Y
-------------
Y
P
----------------------------
D
D
E
N
A
K
T
FELCREEGHSF-----------
A
H
F
L
F
I
E
Q
G
-
M
R
Y
TK
P
--------
G
G
--
Y
L
F
F
L
V
P
D
-
A
----
M
-
F
----
G
T------
S
----
D
F
-
A
K
V
D
K
F
I
K
K
N
G
H
I
E
G
I
I
K
L
P
E
-
T
L
F
K
---------------
S
-
Q
A
R
K
S
I
L
I
L
E
K
A
-----
D
V
D
V
K
P
P
K
E
V
L
L
A
N
------------
L
S
S
L
T
D
P
S
V
T
A
P
I
L
A
E
I
E
N
W
-
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
66.58
16%
-82
- C4 -
3KHK
1
?
A:
[203-448]
------
D
I
L
G
H
-------
V
Y
--
E
Y
F
L
G
Q
F
A
L
A
--
E
G
K
Q
--------
G
G
Q
-
Y
Y
-
T
P
K
S
I
V
T
L
---
I
V
E
M
L
E
P
Y
------------------------
K
G
R
V
Y
D
P
A
M
---
G
S
G
G
F
F
V
------------------
S
S
D
K
F
I
E
K
H
ANVKHYN
A
S
E
Q
K
K
Q
---------------------------
I
---------
S
V
Y
G
Q
E
S
N
P
T
---------
T
W
---------------------
K
L
A
A
M
N
M
V
I
R
G
I
D
F
N
FG
K
------
K
N
A
D
S
F
L
------------------------
D
D
Q
H-
P
----
D
-----
L
R
A
----------
D
F
V
M
T
N
P
P
F
N
M
-------------
K
D
----------------------------
W
WHEKLADDPRW
T
I
N
T
NKRILTPPTGN--
A
N
F
A
W
M
L
H
M
-
L
Y
H
LA
P
--------
T
G
--
S
M
A
L
L
L
A
N
-
G
----
S
-
M
----
S
-------
S
NTN-
N
E
-
G
E
I
R
K
T
L
V
E
Q
D
L
V
E
C
M
V
A
L
P
G
-
Q
L
F
T
---------------
N
T
Q
I
P
A
C
I
W
F
L
T
K
D
-----
K
N
A
K
N
G
K
R
D
R
R
G
Q
V
------------
L
F
I
D
A
R
K
L
G
Y
M
K
D
R
V
L
R
D
F
K
-
D
E
D
I
Q
K
L
A
D
T
---
F
H
---------
N
W
Q
Q
E
W
S
E
E
--
N
N
Q
A
G
-
F
C
-
F
S
A
D
L
A
L
-
I
R
K
N
D
F
V
----
L
T
P
G
R
Y
V
G
--------------------------------------------------------------------------------------------------------
40
HHSearch
66.39
16%
-131
- C4 -
1QAM
2
ERM_BACIU
A:
[10-182]
------------------------------------------------
Q
N
F
I
-
T
S
K
H
N
I
D
K
---
I
M
T
N
I
R
L
N
-------
E
----------------
H
D
N
I
F
E
I
G
S
---
G
K
G
H
F
T
L
------------------
E
L
V
Q
R
C
--------------------------------------------
N
---------
F
V
T
A
I
E
I
D
H
K
---------
L
C
K
T
T
E
N
K
L
V
DHDN
F
--------
Q
----------------
V
------
L
N
K
D
I
L
Q
------------------------
F
K
F
--
P
----
K
-----
N
Q
S
----------
Y
K
I
F
G
N
I
P
Y
N
I
-------------
S
T
----------------------------
D
----------------------------
I
I
R
K
I
V
F
D
S
-
I
-------------
A
D
--
E
I
Y
L
I
V
E
Y
G
F
----
A
-
K
----
R
L
L
-----
N
----
T
K
-
R
S
L
A
L
F
L
M
A
E
V
D
I
S
I
L
S
M
V
P
R
-
E
Y
F
H
P
--------------
K
P
K
V
N
S
S
L
I
R
L
N
R
K
-----
K
S
R
I
S
H
K
D
K
Q
K
Y
N
Y
------------
F
V
M
K
W
V
N
K
E
Y
K
K
I
F
T
K
N
Q
F
N
-
N
S
L
K
H
A
G
I
D
D
---
L
N
---------
N
I
S
F
E
Q
F
L
S
--
L
F
N
S
Y
-
K
L
-
F
N
K
--------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
65.30
17%
-120
- C4 -
3GRU
4
RSMA_METJA
A:
[30-205]
------------------------------------------------
Q
-
C
F
L
I
D
K
N
F
V
N
K
---
A
V
E
S
A
N
L
T
-------
K
----------------
D
D
V
V
L
E
I
G
L
---
G
K
G
I
L
T
E
------------------
E
L
A
K
----------------------------------------------
N
AK-------
K
V
Y
V
I
E
I
D
K
S
---------
L
E
P
Y
A
N
K
L
K
E
L
Y
NN
I
--------
E
----------------
I
------
I
W
G
D
A
L
K
------------------------
V
D
L
--
N
----
K
-----
L
D
F
----------
N
K
V
V
A
N
L
P
Y
Q
I
-------------
S
S
----------------------------
P
----------------------------
I
T
F
K
L
I
K
R
G
---------------
F
D
--
L
A
V
L
M
Y
Q
Y
-
E
----
F
A
K
----
R
M
V
AAAGT
K
----
D
Y
-
G
R
L
S
V
A
V
Q
S
R
A
D
V
E
I
V
A
K
V
P
P
-
S
A
F
Y
--------------
P
K
P
K
V
Y
S
A
I
V
K
I
K
P
N
-----
K
G
K
Y
H
I
E
N
E
N
F
F
D
D
------------
F
L
R
A
I
F
Q
H
R
N
K
S
V
R
K
A
L
I
D
S
-
S
K
E
L
N
Y
N
K
D
E
---
M
K
---------
K
I
L
E
D
F
L
N
T
--
N
S
E
I
K
-
N
L
-
I
N
E
K
V
F
K
-
L
S
V
K
D
I
V
----
N
L
S
N
E
F
Y
R
F
-------------
L
Q
N
R
--------------------------------------------------------------------------------------
53
Fugue
61.86
15%
-64
* C5 *
2AGK
5
HIS4_YEAST
A:
[1-260]
-----
T
K
F
I
G
C
-------
I
D
L
H
N
G
E
V
K
Q
---
Q
--
H
P
--------------------------------
S
S
Y
Y
A
K
L
Y
K
D
R
D
------------------------
V
---
Q
G
C
H
V
I
K
------------------
L
G
P
N
----------------------------------------------
N
---------
D
D
A
A
R
E
A
L
Q
E
---------
S
P
---------------------
Q
----------------
F
------
L
-------------------------------------------------------------
Q
V
G
G
---
G
I
-------------
N
D
----------------------------
T
----------------------------
N
C
L
E
W
L
K
W
A
-
S
----
K
--------------
V
I
V
T
S
W
-
L
----
F
-
T
----
K
-------
E
----
G
H
-
F
Q
L
K
R
L
E
R
-
L
T
E
L
C
G
K
D
R
----------------------------
I
V
V
D
L
S
C
R
K
-----
T
Q
D
--
G
R
W
I
V
A
M
N
K
------------
W
Q
T
L
T
D
L
E
L
N
A
D
T
F
R
E
L
R
K
Y
-
T
-------------
N
---------
E
F
L
I
H
A
G
G
I
--
D
E
L
L
V
-
S
K
-
L
F
E
W
T
K
D
-
Y
D
D
L
K
I
V
----
Y
A
G
--
G
A
K
S
-------------
V
D
D
L
K
L
V
D
E
L
S
------------------
H
G
-------
K
V
D
L
T
F
-
G
S
S
L
D
I
F
G
G
N
L
V
K
F
E
D
C
C
R
W
N
E
K
Q
G
--------------------
39
HHSearch
60.68
16%
-86
- C4 -
2H1R
-
?
A:
[2-179]
--------------------------------------------------
H
L
L
K
N
P
G
I
L
D
K
---
I
I
Y
A
A
K
I
K
-------
S
----------------
S
D
I
V
L
E
I
G
C
---
G
T
G
N
L
T
V
------------------
K
L
L
P
----------------------------------------------
L
A
K-------
K
V
I
T
I
D
I
D
S
R
---------
M
I
S
E
V
K
K
R
C
L
Y
E
GYNNL------
E
----------------
V
----------
A
I
K
------------------------
T
V
F
-------------
P
K
F
----------
D
V
C
T
A
N
I
P
Y
K
I
-------------
S
S
----------------------------
P
----------------------------
L
I
F
K
L
I
S
H
R
P
L
F---
K
--------
C
A
----
V
L
M
F
Q
K
-
E
F
A
E
R
M
-
L
----
A
NVGD---
S
----
N
Y
-
S
R
L
T
I
N
V
K
L
F
C
K
V
T
K
V
C
N
V
N
R
-
S
S
F
N
--------------
P
P
P
K
V
D
S
V
I
V
K
L
I
P
K
-----
E
S
S
F
L
T
N
F
D
E
W
D
N
L
------------
L
R
I
C
F
S
R
K
R
K
T
L
H
A
I
F
K
R
N
A
-
V
L
N
M
L
E
H
N
Y
K
---
N
W
---------
C
T
L
N
K
Q
V
P
V
--
N
F
P
F
K
-
K
Y
-
C
L
D
V
L
E
H
-
L
D
M
C
E
K
R
----
S
I
N
L
D
E
N
D
F
-------------
L
K
L
L
L
E
F
N
K
K
G
------------------
I
H
-------
F
F
--------------------------------------------------
28
HHSearch
59.02
17%
-82
* C4 *
3UFB
-
?
A:
[176-416]
------
H
T
L
S
R
-------
L
Y
--
E
T
M
L
R
E
---
M
R
D
A
A
G
D
--------
S
G
E
-
F
Y
-
T
P
R
P
V
V
R
F
---
M
V
E
V
M
D
P
Q
-------
L
----------------
G
E
S
V
L
D
P
A
C
---
G
T
G
G
F
L
V
------------------
E
A
F
E
H
L
E
R
Q
CKT
V
E
D
R
E
V
L
Q
E
-----------------------------
S
---------
S
I
F
G
G
E
A
K
S
L
---------
P
Y
L
L
V
Q
M
N
L
L
L
H
GLEYP------
R
----------------
I
------
D
P
E
N
S
L
R
------------------------
F
P
L
--
R
EMGD
K
-----
D
R
V
----------
D
V
I
L
T
N
P
P
F
G
G
-------------
E
E
----------------------------
E
K
G
I
L
G
N
F
PEDMQTAE-------------
T
A
M
L
F
L
Q
L
I
-
M
R
K
L-
K
RPGHGSDN
G
G
--
R
A
A
V
V
V
P
N
-
G
----
T
-
L
FS--
D
-------
G
----
I
S
-
A
R
I
K
E
E
L
L
K
N
F
N
L
H
T
I
V
R
L
P
E
-
G
V
F
A
P
--------------
Y
T
D
I
A
G
N
L
L
F
F
D
R
S
-----
G
P
T
D
D
I
W
Y
Y
Q
I
T
V
P
------------
E
G
R
K
K
Y
T
K
T
K
P
M
E
S
H
E
F
D
E
C
-
L
N
W
W
S
N
R
I
V
N
---
Q
N
---------
A
W
K
E
S
A
S
E
I
--
I
K
Y
S
E
-
S
G
-
Q
L
I
D
V
N
L
-
D
R
K
N
P
N
S
----
L
E
V
L
E
H
----------------------------------------------------------------------------------------------------------
37
HHSearch
58.79
12%
-111
- C4 -
1QYR
-
RSMA_ECOLI
A:
[18-200]
------------------------------------------------
N
-
F
L
-
N
D
Q
F
V
I
D
S
---
I
V
S
A
I
N
P
Q
-------
K
----------------
G
Q
A
M
V
E
I
G
P
---
G
L
A
A
L
T
E
------------------
P
V
G
E
----------------------------------------------
R
L
D-------
Q
L
T
V
I
E
L
D
R
D
---------
L
A
A
R
L
Q
T
H
P
F
L
G
P
K
L--------
T
----------------
I
------
Y
Q
Q
D
A
M
T
------------------------
F
N
F
--
G
----
E
L
A
E
K
M
G
Q
P
----------
L
R
V
F
G
N
L
P
Y
N
I
-------------
S
T
----------------------------
P
--------------------------------
L
M
F
H
L
-
F
S
Y
TD
A
--------
I
A
--
D
M
H
F
M
L
Q
K
-
E
----
V
-
V
N
R
L
V
A
-------
G
PNSK
A
Y
-
G
R
L
S
V
M
A
Q
Y
Y
C
N
V
I
P
V
L
E
V
P
P
-
S
A
F
T
P
--------------
P
P
K
V
D
S
A
V
V
R
L
V
P
H
-----
A
T
M
P
H
P
V
K
D
V
R
V
L
S
------------
R
I
T
T
E
A
F
N
Q
R
R
K
T
I
R
N
S
L
G
N
-
L
F
S
V
E
V
L
T
G
M
---
G
I
---------
D
P
A
M
R
A
E
N
I
--
S
V
A
Q
Y
-
C
Q
-
M
A
N
Y
L
A
E
-
N
A
-------------------------------------------------------------------------------------------------------------------------
32
HHSearch
58.18
14%
-87
- C4 -
3S1S
12
?
A:
[273-519]
------
I
L
T
G
D
-------
E
L
--
A
E
L
I
H
D
I
A
T
R
--
G
R
G
H
--------
E
G
V
-
V
P
-
T
D
I
E
L
G
K
V
L
S
I
I
S
Q
H
I
L
G
R
P
----
L
T
E
----------------
D
E
V
I
S
D
P
A
A
---
G
S
G
N
L
L
A
------------------
T
V
S
A
G
FNNVMP---------------------------------------
R
---------
Q
I
W
A
N
D
I
E
T
L
---------
F
L
E
L
L
S
I
R
L
G
L
L
FPQLVSSN
N
A
P
T
----------------
I
------
T
G
E
D
V
C
S
------------------------
L
N
P
--
E
D---
F
-----
A
N
V
----------
S
V
V
V
M
N
P
P
Y
V
S
-------------
G
V
----------------------------
T
D
P
A
I
K
R
K
F
A
H
K
I
I
Q
L
TGNRPQTLFGQIG
V
E
A
L
F
L
E
L
V
-
T
E
L
V
Q
D
--------
G
T
--
V
I
S
A
I
M
P
K
-
Q
----
Y
-
L
----
T
-------
A
QG
N
-
E
S
-
K
A
F
R
E
F
L
V
G
N
F
G
L
E
H
I
F
L
Y
P
R
E
G
L
F
E
---------------
E
V
I
K
D
T
V
V
F
V
G
R
K
G
-----
S
S
V
E
E
I
E
V
L
D
S
F
T
P
------------
L
E
Q
V
D
L
H
N
L
K
R
A
L
S
N
S
S
N
E
Q
-
I
I
Q
P
M
G
M
E
L
R
---
K
E
---------
K
R
E
E
L
E
N
R
V
--
T
V
G
W
R
-
H
I
-
T
S
N
G
R
V
A
-
E
E
W
I
T
N
N
----
L
E
S
H
C
I
R
L
V
-------------
A
S
D
Y
D
L
R
R
G
R
V
------------------
G
N
-------
K
G
A
S
D
L
-
L
F
I
N
S
K
K
K
L
W
D
L
-
L
D
E
S
V
P
R
D
W
L
Y
P
A
L
------------------
48
HHSearch
56.70
19%
-107
- C4 -
3K0B
-
?
A:
[182-352]
------------------------------------------------
S
-
A
P
-
I
K
E
T
M
A
A
A
---
L
V
L
L
T
S
W
H
-------
P
----------------
D
R
P
F
Y
D
P
V
C
---
G
S
G
T
I
P
I
------------------
E
A
A
L
I
G
Q
NIAPGFNREFVSETWDWMP
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
ANYDQP----
L
---------
N
I
I
G
G
D
I
D
A
R
---------
L
I
E
I
A
K
Q
N
A
V
E
A
GLGDL
I
-----
T
----------------
F
------
R
Q
L
Q
V
A
D
------------------------
F
Q
T
-------
E
-----
D
E
Y
----------
G
V
V
V
A
N
P
P
Y
G
E
-------------
R
L
----------------------------
E
D
E
E
A
V
R
Q
---------------------
L
Y
R
E
M
G
I
V
Y
-
K
R
M
--
P
--------
T
W
--
S
V
Y
V
L
T
S
Y
-
E
----
L
-
F
----
E
-------
E
----
V
Y
-
G
K
K
A
T
K
K
R
-
K
L
Y
R
T
D
L
Y
Q
Y
W
G
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
56.17
21%
-91
- C4 -
3TMA
-
?
A:
[188-319]
------------------------------------------------------
T
P
V
L
A
Q
A
---
L
L
R
L
A
D
A
R
-------
P
----------------
G
M
R
V
L
D
P
F
T
---
G
S
G
T
I
A
L
------------------
E
A
A
S
T
LGPT-----------------------------------------
S
---------
P
V
Y
A
G
D
L
D
E
K
---------
R
L
G
L
A
R
E
A
A
L
A
S
GLSW
I
------
R
----------------
F
------
L
R
A
D
A
R
H
------------------------
L
P
R
--
F
----
F
-----
P
E
V
----------
D
R
I
L
A
N
P
P
H
G
L
--------------------------------------------K
E
G
L
F
H
----------------------
L
Y
W
D
F
L
R
G
A
-
L
A
L
LP
P
--------
G
G
--
R
V
A
L
L
T
L
R
-
P
----
A
-
L
----
L
-------
K
----
R
A
-
L
P
P
G
F
A
L
R
-
H
A
R
V
V
E
Q
G
G
V
Y
P
-
R
V
F
V
L
---------
E
-
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
54.06
13%
-94
- C4 -
3TQS
-
RSMA_COXBU
A:
[12-193]
------------------------------------------------
Q
H
F
L
-
H
D
S
F
V
L
Q
K
---
I
V
S
A
I
H
P
Q
-------
K
----------------
T
D
T
L
V
E
I
G
P
---
G
R
G
A
L
T
D
------------------
Y
L
L
T
----------------------------------------------
E
CD-------
N
L
A
L
V
E
I
D
R
D
---------
L
V
A
F
L
Q
K
K
Y
N
QQKN
I
--------
T
----------------
I
------
Y
Q
N
D
A
L
Q
------------------------
F
D
F
--
S
SVK-
T
-----
D
K
P
----------
L
R
V
V
G
N
L
P
Y
N
I
-------------
S
T
----------------------------
P
----------------------------
L
L
F
H
L
F
S
Q
I
-
H
----
C
--------
I
E
--
D
M
H
F
M
L
Q
K
-
E
----
V
-
V
R
R
I
T
A
EVGS---
H
----
D
Y
-
G
R
L
S
V
M
A
Q
Y
F
C
D
N
T
Y
L
F
T
V
S
P
-
Q
A
F
T
P
--------------
P
P
R
V
E
S
A
I
I
R
L
I
P
R
-----
H
N
F
T
P
V
A
K
N
L
D
Q
L
S
------------
H
V
V
K
E
A
F
S
Y
R
R
K
T
V
G
N
A
L
K
K
-
L
I
N
P
S
Q
W
P
L
L
---
E
I
---------
N
P
Q
L
R
P
Q
E
L
--
T
V
E
D
F
-
V
K
-
I
S
N
I
L
N
-----------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.51
14%
-100
- C4 -
1YUB
-
ERM_STREE
A:
[4-181]
-----------------------------------
N
I
K
--------
Y
S
Q
N
F
L
-
T
S
E
K
V
L
N
Q
---
I
I
K
Q
L
N
L
K
-------
E
----------------
T
D
T
V
Y
E
I
G
T
---
G
K
G
H
L
T
T
------------------
K
L
A
K
IS--------------------------------------------
K
---------
Q
V
T
S
I
E
L
D
S
H
---------
L
F
NLSSEKLKLN
T
R
V
--------
T
----------------
L
------
I
H
Q
D
I
L
Q
------------------------
F
Q
F
--
P
----
N
-----
K
Q
R
----------
Y
K
I
V
G
N
I
P
Y
H
L
-------------
S
T
----------------------------
Q
----------------------------
I
I
K
K
V
V
F
E
S
------
R
--------
A
S
--
D
I
Y
L
I
V
E
E
-
G
----
F
-
Y
----
K
R
T
L
----
D
----
I
H
-
R
T
L
G
L
L
L
H
T
Q
V
S
I
Q
Q
L
L
K
L
P
A
-
E
C
F
H
--------------
P
K
P
K
V
N
S
V
L
I
K
L
T
R
H
-----
T
T
D
V
P
D
K
Y
W
K
L
Y
T
Y
------------
F
V
S
K
W
V
N
R
E
Y
R
Q
L
F
T
K
N
Q
F
H
-
Q
A
M
K
H
A
K
V
N
N
---
L
S
---------
T
I
T
Y
E
Q
V
L
S
--
I
F
N
S
Y
-
L
L
-
F
N
G
R
K
------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
52.46
16%
-86
- C4 -
3V97
3
RLMKL_ECOLI
A:
[169-350]
----------------------------------------------
A
G
I
-
A
P
-
I
K
E
T
L
A
A
A
---
I
V
M
R
S
G
W
Q
-------
P
----------------
G
T
P
L
L
D
P
M
C
---
G
S
G
T
L
L
I
------------------
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGWAQHD
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
YS
S
---------
H
F
Y
G
S
D
S
D
A
R
---------
V
I
Q
R
A
R
T
N
A
R
L
A
GIGEL
I
-----
T
----------------
F
------
E
V
K
D
V
A
Q
------------------------
L
T
N
PL
P
----
K
-----
G
P
Y
----------
G
T
V
L
S
N
P
P
Y
G
E
--------------------------------------------SE
P
A
L
I
A
---------------------
L
H
S
L
L
-
G
R
I
-
M
K
N
QF
G
--------
G
W
--
N
L
S
L
F
S
A
S
-
P
----
D
-
L
----
L
-------
S
----
C
L
-
Q
L
R
A
D
K
Q
Y
-
K
A
K
N
G
P
L
D
C
V
Q
K
-
N
Y
H
V
A
---------
E
-
S
M
V
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
-----
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
------------
L
Y
D
A
D
L
P
E
Y
N
V
A
V
D
R
Y
A
D
W
V
-
V
V
Q
E
Y
A
H
K
A
R
---
Q
R
---------
L
F
D
I
I
A
A
T
I
--
S
V
L
G
I
-
A
P
-
N
K
L
V
L
K
T
-
R
E
E
K
G
E
F
----
L
E
V
T
E
Y
N
A
H
-------------
L
W
V
N
L
T
D
Y
L
D
T
------------------
G
L
-------
F
L
D
H
R
I
-
A
R
R
M
L
G
Q
M
S
K
G
K
-
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
------------------
59
Fugue
52.25
17%
-31
- C1 -
1ZR6
7
?
A:
[3-481]
-
E
A
E
F
N
S
I
N
A
C
-------
L
A
A
A
D
V
E
F
H
E
---
E
--
D
S
E
G
--------
W
D
M
-
D
G
-
T
A
F
N
L
R
V
D
---
Y
D
P
A
A
I
A
I
P
R
S
T
E
D
I
A
----------------
A
A
V
Q
C
G
L
D
A
---
G
V
Q
I
S
A
K
G
GGHSYGSYGFGGEDGHL
M
L
E
L
----------------------------------------------
D
---------
R
M
Y
R
V
S
V
D
D
N
N
V
A
T
I
Q
GGA
R
L
---------------------
G
----------------
Y
------
T
A
L
E
L
L
D
Q
GN
R
A
L
S
H
G
TCPAVG
V
G
G
H
V
L
G
G
G
Y
G
F
--
A
----
T
-----
H
T
H
GLTLDWLI
G
A
T
V
V
L
A
D
A
S
I
V
H
V
S
ETEN
A
D
L
F
W
A
L
R
G
GGGGFAI---------------------
V
----------------------------
S
E
F
E
F
N
T
F
E
-
A
----
P
--------
E
I
--
I
T
T
Y
Q
V
T
T
T
W
----
N
-
R
----
K
-------
Q
----
H
V
-
A
G
L
K
A
L
Q
D
-
W
A
Q
N
T
M
P
R
E
L
S
M
-
R
L
E
I
N
AN
A
L
N
W
E
G
N
F
-
F
G
N
A
K
D
L
K
K
I
L
Q
P
I
M
K
K
A
GGKS
T
I
S
K
L
V
E
T
D
W
Y
G
Q
I
N
T
Y
LYGADLNIT
Y
N
Y
D
V
H
E
Y
F
Y
A
N
S
L
T
A
P
R
L
S
-
D
E
A
I
Q
A
F
V
D
Y
---
K
F
DNSSVRPG
R
G
W
W
I
Q
W
D
F
H
GG
K
N
S
A
L
-
A
A
V
S
N
D
E
T
A
Y
A
H
R
D
Q
L
W
L
----
W
Q
F
Y
D
S
I
Y
D
YENNTSPYPESG
F
E
F
M
Q
G
F
V
A
T
I
E
------------------
D
T
LPEDR
K
G
K
Y
F
N
Y
A
D
T
T
L
T
K
E
E
A
Q
K
L
Y
-
W
R
G
N
L
E
K
L
Q
A
I
K
A
K
Y
DPEDVFGNVVSVEPIAY
41
HHSearch
51.63
13%
-77
- C4 -
3FUT
-
RSMA_THET8
A:
[18-202]
--------------------------
G
L
---
F
--
A
D
K
R
--------
F
G
Q
N
F
L
-
V
S
E
A
H
L
R
R
---
I
V
E
A
A
R
P
--------
F
----------------
T
G
P
V
F
E
V
G
P
---
G
L
G
A
L
T
R
------------------
A
L
L
E
----------------------------------------------
A
G
A
-------
E
V
T
A
I
E
K
D
L
R
---------
L
R
P
V
L
E
E
T
L
SGLP
V
---------
R
----------------
L
------
V
F
Q
D
A
L
L
------------------------
Y
P
W
--
E
----
E
V----
P
Q
G
----------
S
L
L
V
A
N
L
P
Y
H
I
-------------
A
T
----------------------------
P
--------------------------------
L
V
T
R
L
-
L
K
---
T
--------
G
R
FA
R
L
V
F
L
V
Q
K
-
E
----
V
-
A
E
R
M
T
A
-------
R
PKTP
A
Y
-
G
V
L
T
L
R
V
A
H
H
A
V
A
E
R
L
F
D
L
P
P
-
G
A
F
F
P
--------------
P
P
K
V
W
S
S
L
V
R
L
T
P
T
-----
G
A
L
D
D
P
G
L
F
R
L
V
E
A
------------
A
F
G
K
R
R
K
T
L
L
N
A
L
A
A
A
G
Y
P
K
-
A
R
V
E
E
A
L
R
A
L
---
G
L
---------
P
P
R
V
R
A
E
E
L
--
D
L
E
A
F
-
R
R
-
L
R
E
G
L
E
-----------------------------------------------------------------------------------------------------------------------------
49
HHSearch
48.85
20%
-73
- C4 -
3LDU
7
?
A:
[181-314]
-------------------------------------------------------
E
T
L
A
A
G
---
L
I
Y
L
T
P
W
-------
K
A
----------------
G
R
V
L
V
D
P
M
C
---
G
S
G
T
I
L
I
------------------
E
A
A
M
I
G
I
NMAPGLNREFISEKWRTLD
K
K
I
W
W
D
V
R
K
D
A
F
N
K
IDNE
S
K
----
F
---------
K
I
Y
G
Y
D
I
D
E
E
---------
S
I
D
I
A
R
E
N
A
E
I
A
GVDEY
I
-----
E
----------------
F
------
N
V
G
D
A
T
Q
------------------------
F
K
S
--
E
----------
D
E
F
----------
G
F
I
I
T
N
P
P
Y
G
E
-------------
R
L
----------------------------
E
----------------------------
D
K
D
S
V
K
Q
L
Y
-
K
----
E
--------
L
G
--
Y
A
F
R
K
L
K
N
-
W
----
S
-
Y
----
Y
-------
L
----
I
T
-
S
Y
E
D
F
E
Y
E
-
F
G
Q
K
A
D
K
K
R
K
L
Y
-
N
G
M
L
K
---------
T
-
N
F
F
Q
Y
P
G
P
K
P
P
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.92
32%
-92
- C4 -
2ADM
1
MTTA_THEAQ
A:
[36-109]
----------------------------------------------------------------------------
E
A
P
R
----------------
G
G
R
V
L
E
P
A
C
---
A
H
G
P
F
L
R
------------------
A
F
R
E
----------------------------------------------
A
HGTG
Y
----
R
F
V
G
V
E
I
D
P
K
---------
A
L
---------------------
D
----------------
L
PPW
A
E
G
I
L
A
D
F
L
L
------------------------
W
E
---
P
----
G
-----
E
A
F
----------
D
L
I
L
G
N
P
P
Y
G
I
-------------
V
G
----------------------------
V
----------------------------
F
K
A
V
K
D
L
Y
K
-
K
----
A
--------
F
S
--
T
W
K
G
K
Y
N
L
-
Y
----
G
-
A
----
F
-------
L
----
E
K
-
A
V
R
L
L
K
P
G
-
G
V
L
V
F
V
V
P
A
T
W
L
-
V
L
E
D
F
---------
A
-
L
L
R
E
F
L
A
R
E
G
K
T
S
V
Y
Y
L
-----
G
E
V
F
P
Q
K
K
V
S
A
V
V
I
------------
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
-
F
T
P
I
L
W
A
E
Y
P
---
H
W
---------
E
G
E
I
I
R
F
E
T
--
E
E
T
R
K
-
L
E
-
I
S
G
M
P
L
G
-
D
L
F
H
I
R
F
----
A
A
R
S
P
E
F
K
K
-------------
H
P
A
V
R
K
E
P
G
P
G
------------------
L
V
-------
P
V
L
T
G
R
-
N
L
K
P
G
W
V
D
Y
E
K
N
-
H
S
G
L
W
M
P
K
E
R
A
K
E
L
------------------