@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1104: (2015-12-20 )
MTPHINAKIGDFYPQCLLCGDPLRVSYIAKNFLQDAKEITNVRNMLGFSGKYKGKGISLMGHGMGIASCTIYVTELIKTYQVKELLRIGTCGAISPKVGLKDIVMATGASTDSKTNRVRFLNHDLSATPDFELSLRAYQTAKRLGIDLKIGNVFSSDFFYSFETHAFGLMAQYNHLAIEMEAAGLYATAMELNAKALCLCSVSDHLITKEALSPKERIESFDNMITLALEMMS
Atome Classification :
(69 SA)
.........10........20........30.....-...40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTPHINA
K
I
G
D
F
Y
P
Q
C
LLCGD
P
L
R
V
S
Y
I
A
K
N
F
L
Q
D
A
-
K
E
I
T
N
V
R
N
M
LGFSGKYKGK
G
I
S
L
M
GHGM
G
I
A
S
C
T
I
Y
V
T
E
L
I
K
T
Y
Q
V
K
E
L
L
RIGTCGAISPKVG
L
K
D
I
V
M
ATGASTDSKT
N
R
V
R
F
LNHDLSATPD
F
E
L
S
L
R
A
Y
Q
T
A
K
RLG
I
D
L
K
IG
N
V
FSS
D
F
F
Y
S
FE
T
H
A
F
G
L
M
AQY
N
H
L
A
I
E
M
EAA
G
L
Y
A
T
A
M
ELN
A
K
A
L
C
L
CSVSDHL
I
T
K
EAL
S
P
K
E
R
I
E
S
F
D
N
M
I
T
L
A
L
E
MMS
12
PsiBlast_PDB
96.44
54%
-127
- C2 -
1K9S
4
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
66
PsiBlast_CBE
96.03
54%
-131
- C2 -
3OOH
2
DEOD_ECOLI
F:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
87
PsiBlast_CBE
95.73
54%
-126
- C2 -
1K9S
4
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
20
PsiBlast_PDB
95.53
54%
-123
- C2 -
4RJ2
3
?
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
41
PsiBlast_CBE
95.52
54%
-127
- C2 -
4TS3
3
?
F:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
27
PsiBlast_CBE
95.50
54%
-128
- C2 -
1PR4
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
---
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
50
PsiBlast_CBE
95.39
54%
-123
- C2 -
4RJ2
1
?
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
97
PsiBlast_CBE
95.36
53%
-126
- C2 -
1OUM
1
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
77
PsiBlast_CBE
95.34
54%
-126
- C2 -
3ONV
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
71
PsiBlast_CBE
95.33
54%
-129
- C2 -
3OOE
4
DEOD_ECOLI
F:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
88
PsiBlast_CBE
95.30
54%
-128
- C2 -
1K9S
4
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
53
PsiBlast_CBE
95.26
54%
-125
- C2 -
3UT6
3
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
38
PsiBlast_CBE
95.25
54%
-126
- C2 -
1OTY
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
16
PsiBlast_PDB
95.23
54%
-126
- C2 -
3ONV
2
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
46
PsiBlast_CBE
95.21
54%
-126
- C2 -
4TS3
3
?
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
18
PsiBlast_PDB
95.13
54%
-129
- C2 -
3OOH
3
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
17
PsiBlast_PDB
95.08
54%
-125
- C2 -
3OOE
4
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
74
PsiBlast_CBE
95.05
54%
-128
- C2 -
3OOE
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
------------
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
14
PsiBlast_PDB
95.02
54%
-124
- C2 -
1PK9
2
DEOD_ECO57
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
80
PsiBlast_CBE
94.96
54%
-127
- C2 -
1PK9
2
DEOD_ECO57
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
19
PsiBlast_PDB
94.86
54%
-125
- C2 -
3UT6
4
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
7
PsiBlast_PDB
94.77
54%
-125
- C2 -
1PW7
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
6
PsiBlast_PDB
94.67
54%
-129
- C2 -
1PR6
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
---
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
28
PsiBlast_CBE
94.51
54%
-124
- C2 -
1PR4
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
4
PsiBlast_PDB
94.43
54%
-128
- C2 -
1PR4
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
-----
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
52
PsiBlast_CBE
94.36
54%
-125
- C2 -
3UT6
5
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
23
PsiBlast_CBE
94.36
54%
-131
- C2 -
1PR6
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
-----
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
82
PsiBlast_CBE
94.24
54%
-130
- C2 -
1PK7
2
DEOD_ECO57
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
81
PsiBlast_CBE
94.06
54%
-124
- C2 -
1PK9
2
DEOD_ECO57
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
15
PsiBlast_PDB
94.06
54%
-124
- C2 -
1PKE
2
DEOD_ECO57
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
3
PsiBlast_PDB
94.06
54%
-123
- C2 -
1PR2
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
1
PsiBlast_PDB
94.06
54%
-124
- C2 -
1PR0
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
102
PsiBlast_CBE
93.99
53%
-123
- C2 -
4TS9
2
?
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
A
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
36
PsiBlast_CBE
93.98
54%
-125
- C2 -
1OU4
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
89
PsiBlast_CBE
93.94
53%
-128
- C2 -
1OVG
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
24
PsiBlast_CBE
93.90
54%
-125
- C2 -
1PR6
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
----
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
93
PsiBlast_CBE
93.82
53%
-123
- C2 -
1OV6
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
29
PsiBlast_CBE
93.82
54%
-122
- C2 -
1PR2
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
39
PsiBlast_CBE
93.79
54%
-131
- C2 -
1A69
4
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
----
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
95
PsiBlast_CBE
93.69
53%
-127
- C2 -
1OUM
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
22
PsiBlast_CBE
93.61
54%
-126
- C2 -
1PW7
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
21
PsiBlast_CBE
93.58
54%
-126
- C2 -
1PW7
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
91
PsiBlast_CBE
93.56
53%
-121
- C2 -
1OVG
2
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
13
PsiBlast_PDB
93.56
54%
-125
- C2 -
1PK7
2
DEOD_ECO57
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
30
PsiBlast_CBE
93.49
54%
-123
- C2 -
1PR2
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
92
PsiBlast_CBE
93.43
53%
-127
- C2 -
1OV6
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
90
PsiBlast_CBE
93.43
53%
-124
- C2 -
1OVG
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
35
PsiBlast_CBE
93.33
54%
-129
- C2 -
1OU4
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
32
PsiBlast_CBE
93.33
54%
-123
- C2 -
1PR1
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
11
PsiBlast_PDB
93.33
54%
-125
- C2 -
1OU4
2
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
40
PsiBlast_CBE
93.31
54%
-125
- C2 -
1A69
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
34
PsiBlast_CBE
93.19
54%
-123
- C2 -
1PR0
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
78
PsiBlast_CBE
92.97
54%
-130
- C2 -
1PKE
2
DEOD_ECO57
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
-----
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
79
PsiBlast_CBE
92.96
54%
-125
- C2 -
1PKE
2
DEOD_ECO57
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
37
PsiBlast_CBE
92.94
54%
-123
- C2 -
1OTY
2
DEOD_ECOLI
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
103
PsiBlast_CBE
92.81
53%
-127
- C2 -
4TS9
4
?
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
A
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
10
PsiBlast_PDB
92.62
54%
-122
- C2 -
1OTY
2
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
83
PsiBlast_CBE
92.42
54%
-124
- C2 -
1PK7
2
DEOD_ECO57
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
5
PsiBlast_PDB
92.42
54%
-125
- C2 -
1PR5
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
------
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
96
PsiBlast_CBE
92.38
53%
-123
- C2 -
1OUM
2
DEOD_ECOLI
B:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
33
PsiBlast_CBE
92.28
54%
-123
- C2 -
1PR0
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
101
PsiBlast_CBE
92.21
53%
-123
- C2 -
4TS9
4
?
C:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
A
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
94
PsiBlast_CBE
92.06
53%
-123
- C2 -
1OV6
2
DEOD_ECOLI
A:
[2-230]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
V
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
31
PsiBlast_CBE
91.69
54%
-122
- C2 -
1PR1
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
26
PsiBlast_CBE
91.61
54%
-127
- C2 -
1PR5
2
DEOD_ECO57
B:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
----
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
2
PsiBlast_PDB
91.55
54%
-126
- C2 -
1PR1
2
DEOD_ECO57
A:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
-----------
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
109
HHSearch
90.34
47%
-122
- C2 -
1Z34
1
?
A:
[2-233]
-
T
P
H
N
S
A
Q
V
G
D
F
A
E
T
V
L
M
C
G
D
P
L
R
A
K
L
I
A
E
T
Y
L
E
N
P
-
K
L
V
N
N
V
R
G
I
Q
G
Y
T
G
T
Y
K
G
K
P
I
S
V
M
G
H
G
M
G
L
P
S
I
C
I
Y
A
E
E
L
Y
S
T
Y
K
V
K
T
I
I
R
V
G
T
C
G
A
I
D
M
D
I
H
T
R
D
I
V
I
F
T
S
A
G
T
N
S
K
I
N
R
I
R
F
M
D
H
D
Y
P
A
T
A
S
F
D
V
V
C
A
L
V
D
A
A
K
E
L
N
I
P
A
K
V
G
K
G
F
S
T
D
L
F
Y
N
P
Q
T
E
L
A
Q
L
M
N
K
F
H
F
L
A
V
E
M
E
S
A
G
L
F
P
I
A
D
L
Y
G
A
R
A
G
C
I
C
T
V
S
D
H
I
L
H
H
E
E
-----
R
Q
N
S
F
Q
N
M
M
K
I
A
L
E
A
A
I
25
PsiBlast_CBE
89.04
54%
-120
- C2 -
1PR5
2
DEOD_ECO57
C:
[3-231]
-
T
P
H
I
N
A
E
M
G
D
F
A
D
V
V
L
M
P
G
D
P
L
R
A
K
Y
I
A
E
T
F
L
E
D
A
-
R
E
V
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
R
K
I
S
V
M
G
H
G
M
G
I
P
S
C
S
I
Y
T
K
E
L
I
T
D
F
G
V
K
K
I
I
R
V
G
S
C
G
A
V
L
P
H
V
K
L
R
D
V
V
I
G
M
G
A
C
T
D
S
K
V
N
R
I
R
F
K
D
H
D
F
A
A
I
A
D
F
D
M
V
R
N
A
V
D
A
A
K
A
L
G
I
D
A
R
V
G
N
L
F
S
A
D
L
F
Y
S
P
D
G
E
M
F
D
V
M
E
K
Y
G
I
L
G
V
E
M
E
A
A
G
I
Y
G
V
A
A
E
F
G
A
K
A
L
T
I
C
T
V
S
D
H
I
R
T
H
E
Q
T
T
A
A
E
R
Q
T
T
F
N
D
M
I
K
I
A
L
E
S
V
L
110
HHSearch
84.40
42%
-116
- C2 -
3UAW
5
DEOD_BACCE
A:
[2-233]
-
S
V
H
I
E
A
K
Q
G
E
I
A
E
S
I
L
L
P
G
D
P
L
R
A
K
Y
I
A
E
-
T
F
L
E
D
V
T
C
Y
N
N
V
R
G
M
L
G
F
T
G
T
Y
K
G
K
R
V
S
V
Q
G
T
G
M
G
V
P
S
I
S
I
Y
V
N
E
L
I
Q
S
Y
G
V
K
N
L
I
R
V
G
T
C
G
A
I
Q
K
D
V
K
V
R
D
V
I
I
A
M
T
A
C
T
D
S
N
M
N
R
L
T
F
P
G
F
D
F
A
P
A
A
N
F
D
L
L
K
K
A
Y
D
A
G
T
E
K
G
L
H
V
R
V
G
N
V
L
T
A
D
V
F
Y
R
E
S
M
D
M
V
K
K
L
G
D
Y
G
V
L
A
V
E
M
E
T
T
A
L
Y
T
L
A
A
K
Y
G
V
N
A
L
S
V
L
T
V
S
D
H
I
F
T
G
E
E
T
T
S
E
E
R
Q
T
T
F
N
E
M
I
E
I
A
L
D
A
A
I