@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0010: (2016-03-11 )
LATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSIKTKFSSAFFSGDLDDMPDFLAGIKALVVDVLNEIGNGECVSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDSKKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKLEIMHFPKKITFVVADTGVPSETRDAVKDVQVLYKENQVEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLETLTVSDSSLEKLIKVARSNGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEWIFTIGEGSYESDSHRTHECGAN
Atome Classification :
(20 SA)
----........--.10........20..-....-----------..---30-........40.------------.---.....--..50----.-----.----------.----.----------.----------------.----..--60---...-----..---------------.--..70----------...---..--------.----.-.--.------------------80........90----.---.......100.......110..--..---------------...120.......130.......140......--..---150-...---..-..--.----.160------------.--...---------------.-------.----...170........-180------------..------------.---..----------------------.-----------.190.---------.------.---------..-------------------------------------------..200------------..---------.-----..---.--..------.210......-------.-----220----..-------....-----...230......-.240.------.......250.....-..260.......270.......280-..---..---.....290.......--300.......310.......320----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----LATGI
G
T
A
--
K
M
I
L
CGE
H
A
V
V
YGEP-AISV-----------P
F
---
T
Q
-
A
V
V
TTNV
E
T
-
S
------------
I
---
K
T
K
FS--SAFF----S-----G----------D----
L
----------
D
----------------
D
----
M
P
--
D
F
---
L
A
G
-----
I
K
---------------
A
--
L
V
V
-----------
D
V
L
---
N
E--------I----G-N--G------------------
E
C
V
S
I
H
V
V
SGVP----I---GRGLG
S
S
A
A
V
A
T
S
I
A
R
G
L
Y
K
Y
F
--
N
Q---------------ELD
S
K
K
L
L
A
I
V
N
A
A
E
K
IAHGNASG
V
-
D
A
I
T
V
V--SE---K---PVW---YE-RD--
R
----
K
L
--------------
E
--
I
M
H---------------F-------P----
K
K
I
T
F
-
V
V
ADTGVP-
S
E
T
------------
R
D
------------
A
---
V
K
----------------------
D
-----------
V
Q
V
L
Y
---------K------E---------NQ-------------------------------------------
V
E
I
--------------
G
K
---------
I
-----
I
H
---
Q
--
L
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------
D
I
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R
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L-------E-----G------DA-------
D
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K
-----I
G
A
A
M
N
K
A
Q
S
Y
L
-
E
T
-LT------VS
D
S
S
L
E
K
L
I
K
V
A
RS-NGADG
A
K
LTGGGRG
G
C
I
I
A
VAK
N
---
Q
E
---
I
A
---
E
Q
I
T
K
A
L
HNAGAA
Q
E
--
W
I
F
T
IGEGSYESDSHRTHECGAN----
40
HHSearch
90.90
34%
-84
- C2 -
2OI2
2
?
A:
[6-290]
-----
G
V
G
Q
A
H
S
--
K
I
I
L
I
G
E
H
A
V
V
Y
G
Y
P
-
A
I
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-----------
P
L
---
L
E
V
E
V
-
T
C
K
V
V
P
A
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------------
S
---
P
W
R
L
Y
------------------------------------------------------------
E
-------------
E
D
T
-----
L
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---------------
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--
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---
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----
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--------
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---
K
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G
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G
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V
F
D
Y
Y
--
Q
A
---------------
D
L
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D
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L
V
N
R
A
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M
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A
H
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---
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----
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--------------
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--
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---------------
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-------
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----
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L
-
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I
A
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G
V
Y
-
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T
------------
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Q
----------------------
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-----------
V
Q
N
K
G
---------
K
------
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---------
A
-------------------------------------------------------------
L
P
---------
F
-----
L
H
---
A
--
L
G
------
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L
T
Q
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-------
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------------
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-------
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A
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-----
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-
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------
V
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S
-
H
G
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I
A
L
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N
---
L
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---
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L
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L
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K
G
A
V
Q
T
--
W
I
E
------------------------
62
Fugue
90.82
26%
-80
- C2 -
1KVK
2
KIME_RAT
A:
[1-394]
MLS
E
V
L
L
V
S
A
P
G
--
K
V
I
L
H
G
E
H
A
V
V
H
G
K
V
-
A
L
A
V
-----------
A
L
---
N
L
-
R
T
F
L
V
L
R
P
Q
-
S
NG
K
V
S
L
N
L
PNVG
I
---
K
Q
V
W
D
--
V
A
T
L
----
Q
-----
L
----------
L
----
D
----------
T
----------------
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----
K
L
--
K
K
---
V
A
G
-----
L
P
R
D
C
V
G
NE
G
L
S
L
L
A
F
L
Y
--
L
Y
L
-----------
A
I
C
---
R
K
--------
Q
----
R
-
T
--
L
------------------
P
S
L
D
I
M
V
W
S
E
L
P
----
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
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A
L
L
T
A
C
--
E
E
VTNPLKDRGS
I
G
S
W
P
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D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
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G
V
-
D
N
S
V
S
T
--
W
G
---
G
---
A
L
R
---
Y
Q
-
Q
G
--
K
----
M
S
--------------
S
--
L
K
R
---------------
L
-------
P
----
A
-
L
Q
I
-
L
L
T
N
T
K
V
P
-
R
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T
------------
K
A
------------
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---
V
A
----------------------
G
-----------
V
R
S
R
L
---------
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------
K
---------
F
P
-------------------------------------------
E
I
M
--------------
A
P
---------
L
-----
L
T
---
S
--
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------
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C
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V
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-------
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-----
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P
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-------
Q
Y
L
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-----
L
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L
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D
M
N
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-
N
A
-
L
G
------
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
G
L
-
H
S
K
L
T
G
A
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G
I
T
L
L
K
P
GLE
R
A
---
K
V
---
E
A
A
K
Q
A
L
T
G
C
G
F
-
D
C
--
W
E
T
S
I
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A
P
G
V
S
M
H
S
A
T
S
I
E
D
P
V
R
Q
A
L
G
61
Fugue
90.61
33%
-85
- C2 -
2OI2
2
?
A:
[4-292]
---K
V
G
V
G
Q
A
H
S
--
K
I
I
L
I
G
E
H
A
V
V
Y
G
Y
P
-
A
I
S
L
-----------
P
L
---
L
E
-
V
E
V
T
C
K
V
V
P
-
A
-----------------------------------------------------
E
----------
S
----------------
P
----
W
R
--
L
Y
---
E
E
D
-----
T
L
---------------
S
--
M
A
V
-----------
Y
A
S
---
L
E
--------
Y
----
L
-
N
--
I
--------------------
T
E
A
C
I
R
C
E
I
D
----
E
---
K
R
G
M
G
S
S
A
A
I
S
I
A
A
I
R
A
V
F
D
Y
Y
--
Q
A
---------------
D
L
P
H
D
V
L
E
I
L
V
N
R
A
E
M
I
A
H
M
N
P
S
G
L
-
D
A
K
T
C
L
--
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---
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---
P
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R
---
F
I
-
K
N
--
V
----
G
F
--------------
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--
E
L
E
---------------
M
-------
D
----
L
S
A
Y
L
-
V
I
A
D
T
G
V
Y
-
G
H
T
------------
R
E
------------
A
---
I
Q
----------------------
V
-----------
V
Q
N
K
G
-----------------------------------------------------------------------
K
D
A
--------------
L
P
---------
F
-----
L
H
---
A
--
L
G
------
E
L
T
Q
Q
A
E
I
A
I
-------
S
-----
Q
------
K
--------
D
A
E
G
-----
L
G
Q
I
L
S
Q
A
H
L
H
L
-
K
E
-
I
G
------
V
S
S
L
E
A
D
S
L
V
E
T
A
L
S
-
H
G
A
L
G
A
K
M
S
G
G
G
L
G
G
C
I
I
A
L
V
T
N
---
L
T
---
H
A
---
Q
E
L
A
E
R
L
E
E
K
G
A
V
Q
T
--
W
I
E
S
L
----------------------
1
PsiBlast_PDB
88.46
33%
-76
- C2 -
2OI2
2
?
A:
[6-292]
-------
G
V
G
Q
A
H
S
K
I
I
L
I
G
E
H
A
V
V
Y
G
Y
P
-
A
I
S
L
-----------
P
L
---
L
E
-
V
E
V
T
C
K
V
----------------
V
---
P
A
E
S
P
--
W
R
L
Y
----
E
-----
E
----------
D
----
T
----------
L
----------------
S
----
M
A
--
V
Y
----
A
S
-----
L
E
---------------
Y
--
L
N
I
----------------------------------
T
--
E
------------------
A
C
I
R
C
E
I
D
--------
E
---
K
R
G
M
G
S
S
A
A
I
S
I
A
A
I
R
A
V
F
D
Y
Y
--
Q
A
---------------
D
L
P
H
D
V
L
E
I
L
V
N
R
A
E
M
I
A
H
M
N
P
S
G
L
-
D
A
K
T
C
L
--
S
D
---
Q
---
P
I
R
---
F
I
-
K
N
--
V
----
G
F
--------------
T
--
E
L
E
---------------
M
-------
D
----
L
S
A
Y
L
-
V
I
A
D
T
G
V
Y
-
G
H
T
------------
R
E
------------
A
---
I
Q
----------------------
V
-----------
V
Q
N
K
G
---------
K
------
D
---------
A
L
-------------------------------------------------------------
P
---------
F
-----
L
H
---
A
--
L
G
------
E
L
T
Q
Q
A
E
I
A
I
-------------
S
------
Q
K
-------
D
A
E
G
-----
L
G
Q
I
L
S
Q
A
H
L
H
L
-
K
E
-
I
G
------
V
S
S
L
E
A
D
S
L
V
E
T
A
L
S
-
H
G
A
L
G
A
K
M
S
G
G
G
L
G
G
C
I
I
A
L
V
T
N
---
L
T
---
H
A
---
Q
E
L
A
E
R
L
E
E
K
G
A
V
Q
T
--
W
I
E
S
L
----------------------
2
PsiBlast_PDB
87.69
25%
-92
- C2 -
2HFU
1
?
A:
[17-324]
--------
I
G
Y
G
--
K
V
I
L
F
G
E
H
F
V
V
H
G
A
E
-
A
I
----------------------
V
A
G
I
S
E
Y
T
-
E
------------
C
---
R
L
E
I
N
--
P
G
V
P
----
G
-----
L
----------
Q
----
V
----------
D
----------------
D
QRPA
I
P
--
G
Y
---
I
A
Q
K
R
D
E
Q
I
K
---------------
A
H
Q
L
V
L
-----------
D
H
L
---
K
V
--------
D
----
L
-
S
--
G
------------------
D
G
L
K
M
F
I
G
G
P
L
V
----
P
---
S
S
G
I
G
A
S
A
S
D
V
V
A
F
S
R
A
L
S
E
L
Y
--
Q
L
---------------
N
L
T
D
E
E
V
N
L
S
A
F
V
G
E
G
G
Y
H
G
T
P
S
G
A
-
D
N
T
A
A
T
--
Y
G
---
G
---
L
I
L
---
Y
R
-
R
Q
--
N
----
G
K
--------------
S
--
V
F
K
P
I
A
------------
F
-------
Q
----
Q
R
L
Y
L
-
V
V
V
G
T
G
I
N
-
A
S
T
------------
A
K
------------
V
---
V
N
----------------------
D
-----------
V
H
K
M
K
---------
Q
------
Q
---------
Q
P
-------------------------------------------
V
Q
F
--------------
K
R
---------
L
-----
Y
D
---
N
--
Y
T
------
H
I
V
S
Q
A
R
E
A
L
-------
Q
------------
K
G
-------
D
L
Q
R
-----
L
G
Q
L
M
N
A
N
H
D
L
C
-
R
Q
-
I
D
------
V
S
C
R
E
L
E
S
I
V
Q
T
C
R
T
-
Y
G
A
L
G
A
K
L
S
G
T
G
R
G
G
I
A
V
A
L
A
A
S
---
S
D
---
Q
R
---
D
A
I
V
K
G
L
K
A
K
C
P
E
A
K
F
I
W
R
Y
T
V
----------------------
41
HHSearch
87.21
27%
-82
- C2 -
1KVK
2
KIME_RAT
A:
[6-372]
-----
L
L
V
S
A
P
G
--
K
V
I
L
H
G
E
H
A
V
V
H
G
K
V
-
A
L
A
V
-----------
A
L
---
N
L
-
R
T
-
F
L
V
L
R
P
Q
S
------------
N
G--
K
V
S
L
N
L
P
N
V
G
I
----
K
Q
V
---
W
D
V
A
T
L
Q
L
LDT----------------
E
----------------
K
----
L
K
--
K
V
---
A
G
L
-----
P
R
---------------
D
--
C
V
G
NE
G
L
S
L
L
A
F
L
Y
L
Y
L
A
I
C
R
K
--------
Q
----
R
-
T
--
L
------------------
P
S
L
D
I
M
V
W
S
E
L
P
----
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
--
E
E
VTNPLKDRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
V
-
D
N
S
V
S
T
--
W
G
---
G
---
A
L
R
---
Y
Q
-
Q
G
--
K
-----
M
--------------
S
--
S
L
K
---------------
R
-------
L
----
P
A
L
Q
I
-
L
L
T
N
T
K
V
P
-
R
S
T
------------
K
A
------------
L
---
V
A
----------------------
G
-----------
V
R
S
R
L
---------
I
------
K
---------
F
P
-------------------------------------------
E
I
M
--------------
A
P
---------
L
-----
L
T
---
S
--
I
D
------
A
I
S
L
E
C
E
R
V
L
G
E
M
A
A
AP
V
------------
P
E
-------
Q
Y
L
V
-----
L
E
E
L
M
D
M
N
Q
H
H
L
-
N
A
-
L
G
------
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
G
-
L
H
S
K
L
T
G
A
G
G
G
G
C
G
I
T
L
L
K
P
---
G
L
---
E
R
A
K
V
E
A
A
K
Q
A
L
T
G
C
G
F
D
C
---
W
E
T
S
I
----------------------
4
PsiBlast_PDB
86.27
31%
-77
- C2 -
4HAC
1
?
B:
[29-305]
--------------
K
I
Y
L
F
G
E
H
A
V
V
Y
G
E
T
-
A
I
A
C
-----------
A
V
EL
R
T
R
-
V
R
A
E
L
N
D
S
I
-
T
------------
I
---
Q
S
Q
I
G
--
R
T
G
L
---------------------
D
----
F
----------
E
----------------
K
----
H
P
--
Y
------------
V
S
---------------
A
--
V
I
E
-----------
K
M
R
---
K
S
--------
I
----
P
I
N
--
G
--------------------
V
F
L
T
V
D
S
D
I
P
----
V
---
G
S
G
L
G
S
S
A
A
V
T
I
A
S
I
G
A
L
N
E
L
F
--
G
F
---------------
G
L
S
L
Q
E
I
A
K
L
G
H
E
I
E
I
K
V
Q
G
A
A
S
P
T
-
D
T
Y
V
S
T
--
F
G
---
G
---
V
V
T
---
I
P
-
E
R
--
R
----
K
L
--------------
K
--
T
------------------------------
P
D
C
G
I
-
V
I
G
D
T
G
V
F
-
S
S
T
------------
K
E
------------
L
---
V
A
----------------------
N
-----------
V
R
Q
L
R
---------
E
------
S
---------
Y
P
-------------------------------------------
D
L
I
--------------
E
P
---------
L
-----
M
T
---
S
--
I
G
------
K
I
S
R
-
I
G
E
Q
L
-------
V
-----
L
------
S
G
-------
D
Y
A
S
-----
I
G
R
L
M
N
V
N
Q
G
L
L
-
D
A
-
L
G
------
V
N
I
L
E
L
S
Q
L
I
Y
S
A
R
A
-
A
G
A
F
G
A
K
I
T
G
A
G
G
G
G
C
M
V
A
L
T
A
P
---
E
K
----
C
---
N
Q
V
A
E
A
V
A
G
A
G
---------------------------------
44
HHSearch
81.89
22%
-66
- C2 -
1PIE
2
GAL1_LACLA
A:
[49-392]
-----
E
Y
F
F
S
P
G
--
R
I
N
L
I
G
E
H
T
D
Y
N
G
G
Y
-
V
F
P
A
-----------
S
I
---
T
I
-
G
T
-
T
G
L
A
R
L
R
E
------------
D
K--
K
V
K
L
Y
--
S
E
N
F
----
P
-----
K
LG
V
I
E
F
----
D
----
L
----------
D
EVEKK-----------
D
----
G
E
--
L
W
---
S
N
Y
-----
V
K
---------------
G
--
M
I
V
-----------
M
L
K
---
G
A
--------
G
----
Y
E
I
--
D
------------------
K
G
F
E
L
L
I
K
G
E
I
P
----
T
---
A
S
G
L
S
S
S
A
S
L
E
L
L
V
G
V
V
L
D
D
L
F
--
N
L
---------------
N
V
P
R
L
E
L
V
Q
L
G
Q
K
T
E
N
D
Y
I
G
V
N
S
G
I
L
D
Q
F
A
I
G
--
F
G
---
E
---
V
K
K
AIE
L
D
-
C
N
--
T
L---
K
Y
--------------
E
--
M
V
P
---------------
V
-------
E
L---
R
D
Y
D
I
-
V
I
M
N
T
N
K
P
-
R
A
L
TE
S
K
Y
N
E
R
F
A
E
T
R
E
------------
A
---
L
K
----------------------
R
-----------
M
Q
T
R
L
---------
D
IQSLGE
L
---------
S
N
-------------------------------------------
E
E
F
--------------
D
A
N
TDLIGD
E
T
L
-----
I
K
---
R
--
A
R
H
A
V
Y
E
N
N
R
T
K
I
A
Q
K
A
F
-------
V
------------
A
G
-------
N
L
T
K
-----
F
G
E
L
L
N
A
S
H
A
S
L
-
K
D
D
Y
E
------
V
T
G
L
E
L
D
T
L
A
E
T
A
Q
K
Q
A
G
V
L
G
A
R
M
T
G
A
G
F
G
G
C
A
I
A
L
V
A
H
---
D
N
----
V
---
S
A
F
R
K
A
V
G
Q
-----------------------------------
6
PsiBlast_PDB
80.68
28%
-93
- C2 -
1VIS
1
MVK_METJA
A:
[9-288]
-----------
S
--
K
V
I
L
F
G
E
H
A
V
V
Y
G
Y
R
-
A
I
S
M
-----------
A
I
---
D
----
L
T
S
T
I
E
I
-
K
------------
E
---
T
Q
E
D
E
--
I
I
L
N
----
L
-----
N
----------
D
----
L
----------
N
K
S
L
G
L
N
LNEIKNINPN
N
----
F
G
--
D
F
K
Y
C
L
C
A
-----
I
K
---------------
N
---
T
L
-----------
D
Y
L
---
N
---------
I
----
E
-
P
--
K
------------------
T
G
F
K
I
N
I
S
S
K
I
P
----
I
---
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
--
N
K
---------------
E
L
K
D
D
E
I
A
K
L
G
Y
M
V
E
K
E
I
Q
G
K
A
S
I
T
-
D
T
S
T
I
T
--
Y
K
---
G
---
I
L
E
---
I
K
-
N
N
--
K
F
R
K
I
K
G
--------------
E
--
F
E
E
---------------
F
-------
L
----
K
N
C
K
F
L
I
V
Y
A
E
K
R
K
-
K
K
T
------------
A
E
------------
L
---
V
N
----------------------
E
-----------
V
A
K
I
-----------------
E
---------
N
K
-------------------------------------------
D
E
I
--------------
F
K
---------
E
-----
I
D
---
K
--
V
I
------
D
E
A
L
K
I
K
N
K
E
-------
D
------------------------------
F
G
K
L
M
T
K
N
H
E
L
L
-
K
K
-
L
N
------
I
S
T
P
K
L
D
R
I
V
D
I
G
N
R
-
F
G
F
-
G
A
K
L
T
G
A
G
G
G
G
C
V
I
I
L
V
-----------------------------------------------------------
5
PsiBlast_PDB
80.63
28%
-92
- C2 -
1KKH
2
MVK_METJA
A:
[12-291]
-----------
S
--
K
V
I
L
F
G
E
H
A
V
V
Y
G
Y
R
-
A
I
S
M
-----------
A
I
---
D
----
L
T
S
T
I
E
I
-
K
------------
E
---
T
Q
E
D
E
--
I
I
L
N
----
L
-----
N
----------
D
----
L
----------
N
K
S
L
G
L
N
LNEIKNINPN
N
----
F
G
--
D
F
K
Y
C
L
C
A
-----
I
K
---------------
N
---
T
L
-----------
D
Y
L
---
N
---------
I
----
E
-
P
--
K
------------------
T
G
F
K
I
N
I
S
S
K
I
P
----
I
---
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
--
N
K
---------------
E
L
K
D
D
E
I
A
K
L
G
Y
M
V
E
K
E
I
Q
G
K
A
S
I
T
-
D
T
S
T
I
T
--
Y
K
---
G
---
I
L
E
---
I
K
-
N
N
--
K
F
R
K
I
K
G
--------------
E
--
F
E
E
---------------
F
-------
L
----
K
N
C
K
F
L
I
V
Y
A
E
K
R
K
-
K
K
T
------------
A
E
------------
L
---
V
N
----------------------
E
-----------
V
A
K
I
-----------------
E
---------
N
K
-------------------------------------------
D
E
I
--------------
F
K
---------
E
-----
I
D
---
K
--
V
I
------
D
E
A
L
K
I
K
N
K
E
-------
D
------------------------------
F
G
K
L
M
T
K
N
H
E
L
L
-
K
K
-
L
N
------
I
S
T
P
K
L
D
R
I
V
D
I
G
N
R
-
F
G
F
-
G
A
K
L
T
G
A
G
G
G
G
C
V
I
I
L
V
-----------------------------------------------------------
12
PsiBlast_PDB
79.15
24%
-75
- C2 -
2R42
2
KIME_RAT
A:
[13-332]
--------------
K
V
I
L
H
G
E
H
A
V
V
H
G
K
V
-
A
L
A
V
A
L
NL
R
T
F
L
V
L
R
P
Q
---
S
N
-
G
K
V
S
L
N
L
P
N
V
G
------------
I
---
K
Q
V
W
D
--
V
A
T
L
Q
L
LD
T
-----
G
----------
F
---------------------------------------QL
E
K
---
L
K
K
-----
V
A
---------------
G
--
L
P
R
-----------
D
C
V
---
G
N
--------
E
----
G
-
L
--
S
L
L
A
F
L
Y
L
Y
L
A
I
C
R
KQR
T
L
P
S
L
D
I
M
V
W
S
E
L
P
----
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
--
E
E
VTNPLKDRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
V
-
D
N
S
V
S
T
--
W
G
---
G
---
A
L
R
---
Y
Q
-
Q
G
--
K
----
M
S
--------------
S
--
L
K
R
---------------
L
-------
P
-----
A
L
Q
I
-
L
L
T
N
T
K
V
P
-
R
S
T
------------
K
A
------------
L
---
V
A
----------------------
G
-----------
V
R
S
R
L
---------
I
------
K
---------
F
P
-------------------------------------------
E
I
M
--------------
A
P
---------
L
-----
L
T
---
S
--
I
D
------
A
I
S
L
E
C
E
R
V
L
G
------
E
-----
M
------
A
A
-------
A
P
V
P
E
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
-
N
A
-
L
G
------
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
G
L
H
-
S
K
L
T
-----------------------------------------------------------------------
47
HHSearch
78.94
24%
-75
- C2 -
1KKH
2
MVK_METJA
A:
[6-310]
-----
M
I
I
E
T
P
S
--
K
V
I
L
F
G
E
H
A
V
V
Y
G
Y
R
-
A
I
S
M
-----------
A
I
---
D
L
-
T
S
-
T
I
E
I
K
E
T
Q
------------
E
D--
E
I
I
L
N
--
L
N
D
L
----
N
-----
K
----------
S
L
G
L
N
L
NEIKNIN---
P
----------------
N
----
N
F
--
G
D
---
F
K
Y
-----
C
L
---------------
C
--
A
I
K
-----------
N
T
L
---
D
Y
--------
L
----
N
-
I
EP
K
------------------
T
G
F
K
I
N
I
S
S
K
I
P
----
I
---
S
C
G
L
G
S
S
A
S
I
T
I
G
T
I
K
A
V
S
G
F
Y
--
N
K
---------------
E
L
K
D
D
E
I
A
K
L
G
Y
M
V
E
K
E
I
Q
G
K
A
S
I
T
-
D
T
S
T
I
T
--
Y
K
---
G
---
I
L
E
---
I
K
-
N
N
--
K
F
R
--
K
I
--------------
K
G
E
F
E
E
---------------
F
-------
L
----
K
N
C
K
F
-
L
I
V
Y
A
E
K
R
K
K
K
T
------------
A
E
------------
L
---
V
N
----------------------
E
-----------
V
A
K
I
E
---------
N
------
K
-----------------------------------------------------------------------
D
E
---------
I
-----
F
K
---
E
--
I
---------
D
K
V
I
D
E
A
L
-------
K
------------
I
K
-------
N
K
E
D
-----
F
G
K
L
M
T
K
N
H
E
L
L
-
K
K
-
L
N
------
I
S
T
P
K
L
D
R
I
V
D
I
G
N
R
-
F
G
-
F
G
A
K
L
T
G
A
G
G
G
G
C
V
I
I
L
V
N
E
---
E
K
----
E
---
K
E
L
L
K
E
L
N
K
E
D
V
R
I
------------------------------
43
HHSearch
77.95
21%
-71
- C2 -
3K17
1
?
A:
[7-359]
-----
L
Q
V
K
I
P
G
--
K
L
Y
V
A
G
E
Y
A
V
V
E
S
G
H
T
A
I
L
T
-----------
A
V
---
N
R
-
Y
I
-
T
L
T
L
E
D
S
E
------------
R
----
N
E
L
W
--
I
P
H
Y
----
E
-----
N
----------
P
V
S
--
W
P
I--------
G
G
E
L
K
------------
P
----
D
G
--
E
H
---
W
T
F
-----
T
A
---------------
E
--
A
I
N
-----------
I
A
T
---
T
F
--------
L
K
S
E
-
G
-
I
E
-
L
------------------
T
P
V
K
M
V
I
E
T
E
L
I
DQSG
A
---
K
Y
G
L
G
S
S
A
A
A
T
V
A
V
I
N
A
L
M
T
K
F
--
Y
P
---------------
E
I
S
M
L
K
K
F
K
L
A
A
L
S
H
L
V
V
Q
G
N
G
S
C
G
-
D
I
A
S
C
M
--
Y
G
---
G
---
W
I
A
---
Y
T
T
F
D
Q
-
E
----
W
V
K
H
R
L
AYKS
L
E
W
F
M
K
E
--
P
W
P
---------------
M
L
Q
I
E
T
L
E
E
----
P
V
P
T
F
-
S
V
G
W
T
G
T
P
-
V
S
T
------------
G
K
------------
L
---
V
S
----------------------
Q
-----------
I
H
A
F
K
---------
Q
------
E
---------
D
S
-------------------------------------------
K
N
Y
--------------
Q
H
---------
F
-----
L
T
---
R
--
N
N
------
E
I
M
K
Q
I
I
Q
A
F
-------
H
------------
T
K
-------
D
E
E
L
-----
L
Y
S
S
I
K
E
N
R
R
I
L
-
Q
E
-
L
G
T
K
A
GVN
I
E
T
S
L
L
K
E
L
A
D
S
A
E
N
-
M
G
-
G
A
G
K
S
S
G
S
G
G
G
D
C
G
I
A
F
S
K
T
---
K
E
---
L
A
---
E
K
L
V
N
E
W
E
K
L
G
I
K
H
L
--
P
F
H
T
G
R
V
Q
I
T
E
G
---------------
48
HHSearch
77.27
22%
-81
- C2 -
2CZ9
3
GAL1_PYRHO
A:
[2-328]
-----
I
K
V
K
S
P
G
--
R
V
N
L
I
G
E
H
T
D
Y
T
Y
G
Y
-
V
M
P
M
-----------
A
I
---
N
L
-
Y
T
-
K
I
E
A
E
K
H
G
------------
E
----
V
I
L
Y
--
S
E
H
F
----
G
-----
E
E
R
K
F
------
S
----
L
----------
N
DLR-------------
K
----
E
N
--
S
W
---
I
D
Y
-----
V
K
---------------
G
--
I
F
W
-----------
V
L
K
---
E
S
--------
D
----
Y
-
E
--
V
------------------
G
G
I
K
G
R
V
S
G
N
L
P
----
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
--
N
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
--
F
G
REG
N
---
V
I
F
---
L
D
-
T
H
--
T
L---
D
Y
--------------
E
--
Y
I
P
---------------
F
-------
P
----
K
D
V
S
I
-
L
V
F
Y
T
G
V
R
-----------------
S
S
-----------
E
---
Y
A
----------------------
E
R
K
H
I
A
E
E
S
L
K
I
L
G
K
G
S
SKEVREGEL
S
------
K
---------
L
P
-------------------------------------------
P
L
H
--------------
R
K
---------
F
-----
F
G
Y
I
V
R
--
E
N
------
A
R
V
L
E
V
R
D
A
L
-------
K
------------
E
G
-------
N
V
E
E
-----
V
G
K
I
L
T
T
A
H
W
D
L
-
A
K
N
Y
E
------
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
-
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
K
---
E
----
D
A
---
E
T
I
G
E
E
I
L
R
E
----------------------------------
11
PsiBlast_PDB
76.69
24%
-77
- C2 -
1KVK
2
KIME_RAT
A:
[13-332]
--------------
K
V
I
L
H
G
E
H
A
V
V
H
G
K
V
-
A
L
A
V
A
L
NL
R
T
F
L
V
L
R
P
Q
---
S
N
-
G
K
V
S
L
N
L
P
N
V
G
------------
I
---
K
Q
V
W
D
--
V
A
T
L
Q
L
LD
T
----------------------------------------------------------
E
K
---
L
K
K
-----
V
A
---------------
G
--
L
P
R
-----------
D
C
V
---
G
N
--------
E
----
G
-
L
--
S
L
L
A
F
L
Y
L
Y
L
A
I
CRKQR
T
L
P
S
L
D
I
M
V
W
S
E
L
P
----
P
---
G
A
G
L
G
S
S
A
A
Y
S
V
C
V
A
A
A
L
L
T
A
C
--
E
E
VTNPLKDRGS
I
G
S
W
P
E
E
D
L
K
S
I
N
K
W
A
Y
E
G
E
R
V
I
H
G
N
P
S
G
V
-
D
N
S
V
S
T
--
W
G
---
G
---
A
L
R
---
Y
Q
-
Q
G
--
K
----
M
S
--------------
S
--
L
K
R
---------------
L
-------
P
-----
A
L
Q
I
-
L
L
T
N
T
K
V
P
-
R
S
T
------------
K
A
------------
L
---
V
A
----------------------
G
-----------
V
R
S
R
L
---------
I
------
K
---------
F
P
-------------------------------------------
E
I
M
--------------
A
P
---------
L
-----
L
T
---
S
--
I
D
------
A
I
S
L
E
C
E
R
V
L
G
------
E
-----
M
------
A
A
-------
A
P
V
P
E
Q
Y
L
V
L
E
E
L
M
D
M
N
Q
H
H
L
-
N
A
-
L
G
------
V
G
H
A
S
L
D
Q
L
C
Q
V
T
A
A
-
H
G
L
H
-
S
K
L
T
-----------------------------------------------------------------------
8
PsiBlast_PDB
74.32
27%
-78
- C2 -
2CZ9
3
GAL1_PYRHO
A:
[69-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
---
V
K
G
-----
I
F
---------------
W
--
V
L
K
-----------
E
S
D
---
Y
E
--------
V
----
G
-
G
-----------------------
I
K
G
R
V
S
G
N
L
P
----
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
--
N
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
FG
R
E
---
G
---
N
V
I
---
F
L
-
D
T
--
H
----
T
L
D
Y
------------
E
--
Y
I
P
---------------
F
-------
P
----
K
D
V
S
I
-
L
V
F
Y
T
G
V
R
-----------------
S
S
E
Y
A
E
R
K
H
I
---
A
---
E
E
----------------------
S
-----------
L
K
I
L
G
---------
K
------
G
---------
S
S
-------------------------------------------
K
E
V
RE------------
G
E
---------
L
SKLP
P
L
H
---
R
K
F
F
G
------
Y
I
V
R
E
N
A
R
V
L
-------
E
V
R
D
A
L
K
------
E
G
-------
N
V
E
E
-----
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
------
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
-
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
K
---
E
D
A
E
T
I
G
---
E
E
I
L
R
---------------------------------------
50
HHSearch
74.29
23%
-74
- C2 -
3V2U
4
GAL3_YEAST
C:
[40-486]
-----
F
I
A
R
S
P
G
--
R
V
N
L
I
G
E
H
I
D
Y
C
D
F
S
-
V
L
P
L
-----------
A
I
---
D
V
-
D
M
-
L
C
A
V
K
I
L
D
------------
E
K
N
P
S
I
T
L
T
--
N
A
D
P
----
K
F
A
Q
R
K
F
----------
D
----
L
PLDG
S
Y
M
A
I
D
P
----------------
S
----
V
S
--
E
W
---
S
N
Y
-----
F
K
---------------
C
--
G
L
H
-----------
V
A
H
---
S
Y
L
K
K
I
APER
F
NN--
T
-
P
--
L
------------------
V
G
A
Q
I
F
C
Q
S
D
I
P
----
T
---
G
G
G
L
S
S
A
F
T
C
A
A
A
L
A
T
-
I
R
A
N
M
GK
N
F
---------------
D
I
S
K
K
D
L
T
R
I
T
A
V
A
E
H
Y
V
G
V
N
N
G
G
M
-
D
Q
A
T
S
V
--
Y
G
---
E
EDH
A
L
Y
---
V
E
-
F
R
P
K
L
----
K
A
--------------
T
--
P
F
K
---------------
F
-------
P
QLKN
H
E
I
S
F
-
V
I
A
N
T
L
V
K
-
S
N
K
------------
F
E
TAPTN
Y
N
L
R
V
I
E
V
T
V
A
A
N
A
L
A
T
R
Y
S
V
A
L
P
S
H
KDNSNSERG
N
-----------
L
R
D
F
M
---------
D
------
A
Y
Y
A
R
YENQA
Q
P
WNGD
I
G
T
G
I
E
R
L
L
K
M
L
Q
L
V
E
E
S
FSRKKSGFT
V
H
E
A
S
T
A
L
NCS
R
E
E
F
T
R
D
YLTT
F
P
V
R
F
QV
L
K
---------
L
-----
Y
Q
---
R
--
A
K
H
V
Y
S
E
S
L
R
V
L
K
A
L
K
M
M
-------
T
------------
S
A
T
F
H
T
D
E
D
F
F
T
D
-----
F
G
R
L
M
N
E
S
Q
A
S
C
-
D
K
L
Y
E
------
C
S
C
I
E
T
N
Q
I
C
S
I
A
L
A
-
N
G
S
F
G
S
R
L
T
G
A
G
W
G
G
C
T
I
H
L
V
P
S
---
G
A
NG-
N
V
---
E
Q
V
R
K
A
L
I
------------------------------------
9
PsiBlast_PDB
74.28
27%
-76
- C2 -
2DEI
2
GAL1_PYRHO
A:
[69-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
---
V
K
G
-----
I
F
---------------
W
--
V
L
K
-----------
E
S
D
---
Y
E
--------
V
----
G
-
G
-----------------------
I
K
G
R
V
S
G
N
L
P
----
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
--
N
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
FG
R
E
---
G
---
N
V
I
---
F
L
-
D
T
--
H
----
T
L
D
Y
------------
E
--
Y
I
P
---------------
F
-------
P
----
K
D
V
S
I
-
L
V
F
Y
T
G
V
R
-
R
E
L
------------
A
S
S
E
Y
A
E
R
K
H
I
---
A
---
E
E
----------------------
S
-----------
L
K
I
L
G
---------
K
------
G
---------
S
S
-------------------------------------------
K
E
V
RE------------
G
E
---------
L
SKLP
P
L
H
---
R
K
F
F
G
------
Y
I
V
R
E
N
A
R
V
L
-------
E
V
R
D
A
L
K
------
E
G
-------
N
V
E
E
-----
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
------
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
-
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
K
---
E
D
A
E
T
I
G
---
E
E
I
L
R
---------------------------------------
10
PsiBlast_PDB
74.12
27%
-82
- C2 -
2DEJ
2
GAL1_PYRHO
A:
[69-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
---
V
K
G
-----
I
F
---------------
W
--
V
L
K
-----------
E
S
D
---
Y
E
--------
V
----
G
-
G
-----------------------
I
K
G
R
V
S
G
N
L
P
----
L
---
G
A
G
L
S
S
S
A
S
F
E
V
G
I
L
E
T
L
D
K
L
Y
--
N
L
---------------
K
L
D
S
L
S
K
V
L
L
A
K
K
A
E
N
E
F
V
G
V
P
C
G
I
L
D
Q
F
A
V
V
F
G
R
E
---
G
---
N
V
I
---
F
L
-
D
T
--
H
----
T
L
D
Y
------------
E
--
Y
I
P
---------------
F
-------
P
----
K
D
V
S
I
-
L
V
F
Y
T
G
V
R
-----------------
S
S
E
Y
A
E
R
K
H
I
---
A
---
E
E
----------------------
S
-----------
L
K
I
L
G
---------
K
------
G
---------
S
S
-------------------------------------------
K
E
V
RE------------
G
E
---------
L
SKLP
P
L
H
---
R
K
F
F
G
------
Y
I
V
R
E
N
A
R
V
L
-------
E
V
R
D
A
L
K
------
E
G
-------
N
V
E
E
-----
V
G
K
I
L
T
T
A
H
W
D
L
A
K
N
-
Y
E
------
V
S
C
K
E
L
D
F
F
V
E
R
A
L
K
-
L
G
A
Y
G
A
R
L
T
G
A
G
F
G
G
S
A
I
A
L
V
D
K
---
E
D
A
E
T
I
G
---
E
E
I
L
R
---------------------------------------
42
HHSearch
71.91
19%
-88
- C2 -
3GON
3
?
A:
[2-327]
-----
I
A
V
K
T
C
G
--
K
L
Y
W
A
G
E
Y
A
I
L
E
P
G
Q
L
A
L
I
K
-----------
D
I
---
P
I
-
Y
M
-
R
A
E
I
A
F
S
D
------------
S
---
Y
-
R
I
Y
--
S
D
M
F
----
D
-----
F
----------
A
----
V
----------
D
L---------------
R
----
P
N
--
P
D
---
Y
S
L
-----
I
Q
---------------
E
--
T
I
A
-----------
L
M
G
---
D
F
--------
L
A
V
R
G
Q
-
N
--
L
------------------
R
P
F
S
L
A
I
Y
G
K
M
E
----
R
EGK
K
F
G
L
G
S
S
G
S
V
V
V
L
V
V
K
A
L
L
A
L
Y
--
N
L
---------------
S
V
D
Q
N
L
L
F
K
L
T
S
A
V
L
L
K
R
G
D
N
G
S
M
G
-
D
L
A
C
I
A
--
A
E
---
D
---
L
V
L
---
Y
Q
-
S
F
D
R
Q
----
K
V
A
A
W
L
E
E
--------
E
--
N
L
A
T
V
L
E
RDWG
F
S
I
S
Q
V
K
P
-------
T
----
L
E
C
D
F
-
L
V
G
W
T
K
E
V
-
A
V
S
------------
S
H
------------
M
---
V
Q
----------------------
Q
-----------
I
K
Q
N
I
---------
N
------
Q
------------------------------------------------------------------------
N
---------
F
-----
L
T
---
S
--
S
K
------
E
T
V
V
S
L
V
E
A
L
-------
E
------------
Q
G
-------
K
S
E
K
-----
I
I
E
Q
V
E
V
A
S
K
L
L
-
E
G
-
L
S
TD----
I
Y
T
P
L
L
R
Q
L
K
E
A
S
Q
D
-
L
Q
A
-
V
A
K
S
S
G
A
G
G
G
D
C
G
I
A
L
S
F
D
---
A
Q
---
S
T
---
K
T
L
K
N
R
W
A
D
L
G
I
E
L
L
--
Y
Q
E
------------------------