@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0554: (2016-03-16 )
MQKEMLNFDYYNPTHIIFGKNRFNELNEVIPQDKKVLILYGGGSVERFGTLDKVKAALKSREVGEFGGIEANPTYETLIKAIQLVKEENYDFLLAVGGGSVIDGTKFVAAGALFDGEPMDIFGSGIGEKRPITKALPFGTVLTLPATGSEMNSGGVITFVEKKAKLGFGSAYTYPVFSLLDPELTYTLPKRQLANGIMDAYVHVMEQYMTYPVGALLQDRYAESLLQTLIEIGPDVIKEDNHDYNTRATFMWSATNALNGTLSRGVPQDWASHSLGHEITALYGIDHARTLAIVLPSLLNVRRSEKHDKLVQYAERVWGITSGSDEEKIDAAILKTREFFESLGAGTRFSDYGLGEEVVDLLVDQLDRHGLTNISERGDQTLEVSRQIYTNAL
Atome Classification :
(20 SA)
.........10-........20...---....----------.30.--.--.-.....40........50......--..60--....--....70........80........90........100.......110..--..-...120.-......130..-..-...140.....--..150.......160.......170.......180.......190.......200.......210-.---..---......220...---....230......---.240.......250-........260....-.-..270----.......280.......290.......300.......310..----...-..320-..-.--.....330.......340.......350........360....--...370------........380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQKEMLNFDYY-N
P
T
H
I
I
FGK
N
R
F
N
---
E
L
N
E
----------VIPQ--D--
K
-
K
V
L
I
L
YGGGS
V
E
RFG
T
L
D
K
V
K
A
A
--
L
KSR--EVGE--FGGIEANP
T
Y
E
T
L
I
K
A
I
Q
L
V
KEENY
D
F
L
L
A
VGGGSVIDGT
K
F
V
A
AGALF--DG-E
P
M
D
I
F
G-SGIGEKRPITK-AL-PFG
T
V
L
T
LPAT--GSEMNSG
G
V
I
T
F
V
EKKAKLGFGSAY
T
Y
P
V
F
S
LLDPE
L
T
Y
TL
P
K
R
Q
L
A
N
G
I
M
D
A
Y
V
H
V
M
E
Q
Y
MT---Y---
P
V
---
G
A
L
L
Q
D
R
Y
A
E
S
L
---
L
Q
T
L
I
E
IG
P
D
V
IK---EDNHDYN
T
R
A
T
F
M
--
W
SATNALNGTLSRGV-
P
-
Q
D
W
A
S
----HSLGH
E
I
T
A
L
YGIDH
A
R
T
L
A
I
V
L
P
S
L
L
N
V
R
RS
E
K
H
D
K
L
V
Q
Y
A
----
E
R
V
-WGIT--SG-S--D
E
E
K
I
D
A
A
I
L
K
T
R
E
F
F
E
S
LGAGTRFS-DYG
L
G
E
E
V
V
D
L
L
V
D
Q
L
--
D
RHG-L------T
N
I
S
ERGD
Q
T
L
E
V
S
R
Q
I
YTNAL
22
PsiBlast_CBE
99.79
56%
-101
- C5 -
1OJ7
3
YQHD_ECOLI
C:
[24-407]
------
N
F
N
L
H
-
T
P
T
R
I
L
F
G
K
G
A
I
A
---
G
L
R
E
----------
Q
I
P
H
--
D
--
A
-
R
V
L
I
T
Y
G
G
G
S
V
K
K
T
G
V
L
D
Q
V
L
D
A
--
L
K
G
M
--
D
V
L
E
--
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
I
L
Q
-
T
G
G
K
E
---
I
K
S
-
A
I
-
P
M
G
C
V
L
T
L
P
A
T
--
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
---
K
---
P
V
---
D
A
K
I
H
D
R
F
A
E
G
I
---
L
L
T
L
I
E
D
G
P
K
A
L
K
---
E
P
E
-
N
Y
D
V
R
A
N
V
M
--
W
A
A
T
Q
A
L
N
G
L
I
G
A
G
V
-
P
-
Q
D
W
A
T
----
H
M
L
G
H
E
L
T
A
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
----
E
R
V
-
W
N
I
T
--
E
G
-
S
--
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
-
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
K
L
--
E
E
H
G
-
M
------
T
Q
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
-
21
PsiBlast_CBE
98.80
56%
-91
- C5 -
1OJ7
2
YQHD_ECOLI
D:
[24-407]
------
N
F
N
L
H
-
T
P
T
R
I
L
F
G
K
G
A
I
A
---
G
L
R
E
----------
Q
I
P
H
--
D
--
A
-
R
V
L
I
T
Y
G
G
G
S
V
K
K
T
G
V
L
D
Q
V
L
D
A
--
L
K
G
M
--
D
V
L
E
--
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
I
L
Q
-
T
G
G
K
E
---
I
K
S
-
A
I
-
P
M
G
C
V
L
T
L
P
A
T
--
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
---
K
---
P
V
---
D
A
K
I
H
D
R
F
A
E
G
I
---
L
L
T
L
I
E
D
G
P
K
A
L
K
---
E
P
E
-
N
Y
D
V
R
A
N
V
M
--
W
A
A
T
Q
A
L
N
G
L
I
G
A
G
V
-
P
-
Q
D
W
A
T
----
H
M
L
G
H
E
L
T
A
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
----
E
R
V
-
W
N
I
T
--
E
G
-
S
--
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
-
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
K
L
--
E
E
H
G
-
M
------
T
Q
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
-
1
PsiBlast_PDB
98.60
56%
-91
- C5 -
1OJ7
2
YQHD_ECOLI
A:
[24-407]
------
N
F
N
L
H
-
T
P
T
R
I
L
F
G
K
G
A
I
A
---
G
L
R
E
----------
Q
I
P
H
--
D
--
A
-
R
V
L
I
T
Y
G
G
G
S
V
K
K
T
G
V
L
D
Q
V
L
D
A
--
L
K
G
M
--
D
V
L
E
--
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
I
L
Q
-
T
G
G
K
E
---
I
K
S
-
A
I
-
P
M
G
C
V
L
T
L
P
A
T
--
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
---
K
---
P
V
---
D
A
K
I
H
D
R
F
A
E
G
I
---
L
L
T
L
I
E
D
G
P
K
A
L
K
---
E
P
E
-
N
Y
D
V
R
A
N
V
M
--
W
A
A
T
Q
A
L
N
G
L
I
G
A
G
V
-
P
-
Q
D
W
A
T
----
H
M
L
G
H
E
L
T
A
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
----
E
R
V
-
W
N
I
T
--
E
G
-
S
--
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
-
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
K
L
--
E
E
H
G
-
M
------
T
Q
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
-
23
PsiBlast_CBE
98.46
56%
-89
- C5 -
1OJ7
2
YQHD_ECOLI
B:
[24-407]
------
N
F
N
L
H
-
T
P
T
R
I
L
F
G
K
G
A
I
A
---
G
L
R
E
----------
Q
I
P
H
--
D
--
A
-
R
V
L
I
T
Y
G
G
G
S
V
K
K
T
G
V
L
D
Q
V
L
D
A
--
L
K
G
M
--
D
V
L
E
--
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
I
L
Q
-
T
G
G
K
E
---
I
K
S
-
A
I
-
P
M
G
C
V
L
T
L
P
A
T
--
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
---
K
---
P
V
---
D
A
K
I
H
D
R
F
A
E
G
I
---
L
L
T
L
I
E
D
G
P
K
A
L
K
---
E
P
E
-
N
Y
D
V
R
A
N
V
M
--
W
A
A
T
Q
A
L
N
G
L
I
G
A
G
V
-
P
-
Q
D
W
A
T
----
H
M
L
G
H
E
L
T
A
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
----
E
R
V
-
W
N
I
T
--
E
G
-
S
--
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
-
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
K
L
--
E
E
H
G
-
M
------
T
Q
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
-
51
Fugue
96.52
54%
-83
- C5 -
1OJ7
2
YQHD_ECOLI
A:
[19-408]
-
K
A
G
L
N
N
F
N
L
H
-
T
P
T
R
I
L
F
G
K
G
A
I
A
---
G
L
R
E
----------
Q
I
P
H
--
D
--
A
-
R
V
L
I
T
Y
G
G
G
S
V
K
K
T
G
V
L
D
Q
V
L
D
A
--
L
K
G
M
--
D
V
L
E
--
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
--
P
E
-
N
I
D
P
-
W
H
-
I
L
Q
T
G
G
K
E
I
K
S
-
A
I
-
P
M
G
C
V
L
T
L
P
A
T
--
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
---
K
---
P
V
---
D
A
K
I
H
D
R
F
A
E
G
I
---
L
L
T
L
I
E
D
G
P
K
A
L
K
----
E
P
E
N
Y
D
V
R
A
N
V
M
--
W
A
A
T
Q
A
L
N
G
L
I
G
A
G
V
-
P
-
Q
D
W
A
T
----
H
M
L
G
H
E
L
T
A
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
----
E
R
V
-
W
N
I
T
--
E
G
-
S
--
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
-
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
K
L
--
E
E
H
G
-
M
------
T
Q
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
R
32
HHSearch
87.24
36%
-79
- C5 -
1VLJ
2
?
A:
[12-406]
---
H
M
E
N
F
V
F
H
-
N
P
T
K
I
V
F
G
R
G
T
I
P
---
K
I
G
E
----------
E
I
K
N
A
-
G
--
I
R
K
V
L
F
L
Y
G
G
G
S
I
K
K
N
G
V
Y
D
Q
V
V
D
S
L
K
K
H
G
I
--
E
W
V
E
--
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
A
F
I
-
G
K
---
Y
-
Q
I
E
K
-
A
L
-
P
I
F
D
V
L
T
I
S
A
T
--
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
---
G
---
S
----
S
P
E
I
S
N
E
I
A
E
G
T
---
I
R
T
I
M
K
M
T
E
R
L
I
E
---
K
P
D
-
D
Y
E
A
R
A
N
L
A
--
W
S
A
T
I
A
L
N
G
T
M
A
V
G
R
R
G
-
G
E
W
A
C
----
H
R
I
E
H
S
L
S
A
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
----
K
K
I
-
F
G
F
E
--
G
E
----
G
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
-
D
A
G
I
P
E
E
D
I
D
K
I
V
D
N
V
--
M
L
L
V
E
K
NLKPKG
A
S
L
G
R
I
M
V
L
E
R
E
D
V
R
E
I
L
K
L
A
A
2
PsiBlast_PDB
86.47
38%
-90
- C5 -
1VLJ
2
?
A:
[13-372]
----
M
E
N
F
V
F
H
-
N
P
T
K
I
V
F
G
R
G
T
I
P
---
K
I
G
E
----------
E
I
K
N
--
A
GI
R
-
K
V
L
F
L
Y
G
G
G
S
I
K
K
N
G
V
Y
D
Q
V
V
D
S
--
L
K
K
H
G
I
E
W
V
E
--
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
A
F
----
I
G
-
K
Y
Q
I
E
K
-
A
L
-
P
I
F
D
V
L
T
I
S
A
T
--
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
---
G
---
S
----
S
P
E
I
S
N
E
I
A
E
G
T
---
I
R
T
I
M
K
M
T
E
R
L
I
----
E
K
P
D
D
Y
E
A
R
A
N
L
A
--
W
S
A
T
I
A
L
N
G
T
M
A
V
G
R
-
R
G
G
E
W
A
C
----
H
R
I
E
H
S
L
S
A
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
----
K
K
I
-
F
G
F
---
E
G
-
E
--
G
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
-
D
A
G
I
P
E
E
D
I
D
K
I
V
D
N
V
------------------------------------
24
PsiBlast_CBE
85.90
38%
-91
- C5 -
1VLJ
2
?
B:
[13-372]
----
M
E
N
F
V
F
H
-
N
P
T
K
I
V
F
G
R
G
T
I
P
---
K
I
G
E
----------
E
I
K
N
--
A
GI
R
-
K
V
L
F
L
Y
G
G
G
S
I
K
K
N
G
V
Y
D
Q
V
V
D
S
--
L
K
K
H
G
I
E
W
V
E
--
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
A
F
----
I
G
-
K
Y
Q
I
E
K
-
A
L
-
P
I
F
D
V
L
T
I
S
A
T
--
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
---
G
---
S
----
S
P
E
I
S
N
E
I
A
E
G
T
---
I
R
T
I
M
K
M
T
E
R
L
I
----
E
K
P
D
D
Y
E
A
R
A
N
L
A
--
W
S
A
T
I
A
L
N
G
T
M
A
V
G
R
-
R
G
G
E
W
A
C
----
H
R
I
E
H
S
L
S
A
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
----
K
K
I
-
F
G
F
---
E
G
-
E
--
G
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
-
D
A
G
I
P
E
E
D
I
D
K
I
V
D
N
V
------------------------------------
28
HHSearch
72.19
22%
-67
- C5 -
3OX4
2
ADH2_ZYMMO
A:
[2-383]
-----
A
S
S
T
F
Y
-
I
P
F
V
N
E
M
G
E
G
S
L
E
---
K
A
I
K
----------
D
L
N
G
S-
G
--
F
K
N
A
L
I
V
S
D
A
F
M
-
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
--
N
S
A
V
--
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
Y
E
G
-
I
D
---
K
-
S
K
K
P
-
A
L
-
P
L
M
S
I
N
T
T
A
G
T
--
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
---
T
---
A
----
A
T
P
I
T
D
A
C
A
L
K
A
---
A
S
M
I
A
K
N
L
K
T
A
C
D
---
N
G
K
-
D
M
P
A
R
E
A
M
A
--
Y
A
Q
F
L
A
G
M
A
F
N
---
N
-
A
-
S
L
G
Y
V
----
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
----
V
A
M
-
G
L
D
I
--
A
N
-
L
G-
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
-
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
--
L
K
D
A
--------
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
33
HHSearch
72.11
25%
-86
- C5 -
1O2D
3
?
A:
[13-369]
------
V
W
E
F
Y
-
M
P
T
D
V
F
F
G
E
K
I
L
E
---
K
R
G
N
----------
I
I
D
L
L-
G
--
K
-
R
A
L
V
V
T
G
K
S
S
S
K
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
--
S
Y
E
I
--
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
--
K
D
L
S
V
E
D
L
Y
D
-
R
E
-----
K
V
K
H
-
W
L
-
P
V
V
E
I
P
T
T
A
G
T
--
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
-
N
K
R
G
C
--
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
---
R
---
K
----
S
T
P
P
S
D
A
L
A
I
E
A
---
M
K
I
I
H
R
N
L
P
K
A
I
E
---
G
---
N
R
E
A
R
K
K
M
F
--
V
A
S
C
L
A
G
M
V
I
A
---
Q
-
T
-
G
T
T
L
A
----
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
M
E
V
M
K
E
E
I
P
E
K
V
D
T
V
N
----
H
I
F
--
G
-------------------
G
S
L
L
K
F
L
K
E
L
G
L
Y
E
K
V
----
A
V
S
S
E
E
L
E
K
W
V
E
K
G
--
S
R
A
K
--------
H
L
K
N
T
P
G
T
F
T
P
E
K
I
R
N
I
Y
R
E
A
L
29
HHSearch
71.64
22%
-72
- C5 -
3BFJ
1
DHAT_KLEPN
A:
[4-387]
-----
R
M
F
D
Y
L
-
V
P
N
V
N
F
F
G
P
N
A
I
S
---
V
V
G
E
----------
R
C
Q
L
L
-
G
G-
K
-
K
A
L
L
V
T
D
K
G
L
R
-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
--
E
V
A
I
--
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
--
E
G
-
D
L
Y
Q
Y
A
G
-
I
E
---
T
-
L
T
N
P
-
L
P
-
P
I
V
A
V
N
T
T
A
G
T
--
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
---
K
---
D
----
A
N
P
V
T
D
A
A
A
M
Q
A
---
I
R
L
I
A
R
N
L
R
Q
A
V
A
---
L
G
S
-
N
L
Q
A
R
E
Y
M
A
--
Y
A
S
L
L
A
G
M
A
F
N
---
N
-
A
-
N
L
G
Y
V
----
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
----
E
L
M
-
G
E
N
I
--
T
G
-
L
S-
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
-
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
--
L
K
D
G
--------
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
30
HHSearch
69.78
20%
-67
- C5 -
1RRM
4
FUCO_ECOLI
A:
[2-383]
-----
M
A
N
R
M
I
-
L
N
E
T
A
W
F
G
R
G
A
V
G
---
A
L
T
D
----------
E
V
K
R
R
-
G
--
Y
Q
K
A
L
I
V
T
D
K
T
L
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
--
A
W
A
I
--
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
--
P
E
-
F
-
A
D
V
R
S
-
L
E
-
G
L
S
P
T
N
K
P
-
S
V
-
P
I
L
A
I
P
T
T
A
G
T
--
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
---
R
---
G
----
A
W
A
L
T
D
A
L
H
I
K
A
---
I
E
I
I
A
G
A
L
R
G
S
V
A
---
G
---
D
K
D
A
G
E
E
M
A
--
L
G
Q
Y
V
A
G
M
G
F
S
---
N
-
V
-
G
L
G
L
V
----
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
----
R
V
M
--
G
V
K
--
V
E
-
G
MS
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
-
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
--
L
D
D
V
--------
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
34
HHSearch
68.78
22%
-80
- C5 -
3W5S
7
?
A:
[21-365]
----
M
Q
P
F
V
Y
T
T
A
P
A
R
I
V
F
G
T
G
S
S
V
---
G
V
A
E
----------
E
I
R
R
L
-
G
--
L
S
R
A
L
V
L
S
T
P
H
Q
K
---
G
D
A
E
A
L
A
A
R
--
L
G
P
L
--
A
A
G
V
--
F
S
D
A
A
M
H
T
P
V
E
V
T
K
R
A
V
E
A
Y
R
A
A
G
A
D
C
V
V
S
L
G
G
G
S
T
T
G
L
G
K
A
I
A
L
R
T
---------------------------
D
A
-
P
Q
I
V
I
P
T
T
Y
-
A
--
G
S
E
V
T
P
I
L
G
Q
T
E
N
--
G
V
K
T
T
L
R
G
P
E
I
L
P
E
V
V
I
Y
D
A
E
L
T
L
G
L
P
V
G
I
S
M
T
S
G
L
N
A
M
A
H
A
A
E
A
L
Y
A
---
R
---
D
----
R
N
P
I
A
S
M
M
A
V
E
G
---
L
R
A
M
I
E
A
L
P
G
V
R
M
---
E
P
Q
-
D
T
K
A
R
E
T
A
L
--
Y
G
A
W
L
C
G
T
V
L
G
---
A
-
V
-
G
M
S
L
H
----
H
K
L
C
H
T
L
G
G
S
L
D
L
P
H
A
E
T
H
A
V
L
L
P
Y
T
I
A
Y
V
E
Q
A
V
P
D
Q
L
A
P
L
A
----
A
L
V
-
G
-
G
R
---------------
A
G
T
G
L
Y
D
F
A
A
R
L
G
A
P
A
S
L
A
-
A
L
G
V
G
G
E
D
L
D
A
M
A
E
L
A
--
T
A
N
----------
P
Y
W
C
P
R
P
V
E
K
T
A
I
R
A
L
L
Q
R
A
F
8
PsiBlast_PDB
68.58
22%
-55
- C5 -
4FR2
1
?
A:
[17-376]
-------
Y
D
F
L
-
M
P
S
V
N
F
F
G
P
G
V
I
S
---
K
I
G
E
R
A
K
M
L
GM
K
K
P
V
I
V
T
--
D
--
K
-
F
L
E
N
L
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
-------
S
G
V
--
D
Y
V
V
--
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
--
G
A
G
I
I
M
T-
N
G
-
D
D
I
T
K
L
A
-
G
I
E
T
L
K
N
P
L
P
-----
P
L
I
A
V
N
T
T
A
G
T
--
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
---
V
---
D
H
---
N
P
I
T
D
S
Q
C
I
Q
A
I
-----
K
L
I
E
S
S
L
R
E
A
V
---
A
N
G
H
N
L
Q
A
R
---------
T
K
M
V
E
A
E
M
L
A
G
M
-
A
-
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
----
R
I
M
-
G
E
N
T
--
D
G
L
S
--
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
-
D
I
G
A
K
P
E
D
F
D
L
M
A
E
N
A
--
L
K
D
G
------------------------------
3
PsiBlast_PDB
68.53
26%
-66
- C5 -
3OWO
1
ADH2_ZYMMO
A:
[42-372]
---------------------------------------------------------------
M
N
K
S
G
V
V
K
Q
V
A
D
L
--
L
K
A
Q
--
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
Y
E
G
-
I
D
-
K
S
K
K
P
----
A
L
-
P
L
M
S
I
N
T
T
A
G
T
--
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
TAA
T
---
P
I
---
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
---
R
E
A
M
A
Y
---
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
----------------
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
----
V
A
M
G
L
D
I
A
--
N
L
-
G
--
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
-
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
-
L
------
T
N
-
P
R
Q
G
D
Q
-------------
4
PsiBlast_PDB
68.11
26%
-65
- C5 -
3OX4
2
ADH2_ZYMMO
A:
[42-372]
---------------------------------------------------------------
M
N
K
S
G
V
V
K
Q
V
A
D
L
--
L
K
A
Q
--
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
Y
E
G
-
I
D
-
K
S
K
K
P
----
A
L
-
P
L
M
S
I
N
T
T
A
G
T
--
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
TAA
T
---
P
I
---
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
---
R
E
A
M
A
Y
---
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
----------------
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
----
V
A
M
G
L
D
I
A
--
N
L
-
G
--
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
-
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
-
L
------
T
N
-
P
R
Q
G
D
Q
-------------
9
PsiBlast_PDB
67.41
22%
-69
- C5 -
2BI4
2
FUCO_ECOLI
A:
[62-391]
----------------------------------------------------------------------
D
K
M
D
A
A
--
G
L
A
W
--
A
I
----
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
---
I
I
--
S
N
-
N
P
E
F
A
D
V
-
R
S
L
E
G
L
S
P
T
N
K
P
S
V
-
P
I
L
A
I
P
T
T
A
G
T
--
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
---
R
---
G
A
---
W
A
L
-----
T
D
A
L
---
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
--
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
-------
V
----
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
-----
R
V
-
M
G
V
K
VE
G
M
-
S
--
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
-
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
--
L
D
D
V
-
C
------
T
G
G
N
P
R
-
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
7
PsiBlast_PDB
67.35
26%
-73
- C5 -
3BFJ
1
DHAT_KLEPN
A:
[6-353]
-------
F
D
Y
L
-
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
----------
L
L
G
G
--
K
--
K
-
A
L
L
V
T
D
K
G
L
R
--
K
D
G
A
V
D
K
T
L
H
Y
--
L
R
E
A
G
I
E
V
A
I
--
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
--
E
G
----
D
L
Y
Q
Y
A
G
I
---
E
T
L
T
N
-
P
L
P
P
I
V
A
V
N
T
T
A
G
T
--
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
---
K
DAN
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
---
L
R
Q
A
V
A
L
G
S
N
L
Q
A
---
R
E
Y
M
A
Y
A
S
L
L
A
G
M
---
A
F
N
N
A
N
L
G
Y
V
----------------
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
-
T
G
L
S
--
T
L
-
D
--
A
A
E
K
A
I
A
A
I
-------------
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
--
D
---------------------------------
10
PsiBlast_PDB
67.29
22%
-69
- C5 -
2BL4
2
FUCO_ECOLI
A:
[62-391]
----------------------------------------------------------------------
D
K
M
D
A
A
--
G
L
A
W
--
A
I
----
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
---
I
I
--
S
N
-
N
P
E
F
A
D
V
-
R
S
L
E
G
L
S
P
T
N
K
P
S
V
-
P
I
L
A
I
P
T
T
A
G
T
--
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
---
R
---
G
A
---
W
A
L
-----
T
D
A
L
---
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
--
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
-------
V
----
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
-----
R
V
-
M
G
V
K
VE
G
M
-
S
--
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
-
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
--
L
D
D
V
-
C
------
T
G
G
N
P
R
-
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
-
12
PsiBlast_PDB
66.96
23%
-92
- C5 -
3JZD
6
?
A:
[17-326]
----------------
V
V
F
G
A
G
S
S
S
---
Q
V
A
A
----------
E
V
E
R
L
G
A
--
K
-
R
A
L
V
L
C
---
T
P
N
Q
Q
A
E
A
E
R
I
A
D
L
--
L
G
P
L
--
S
A
G
V
--
Y
A
G
A
V
M
H
V
P
I
E
S
A
R
D
A
T
A
R
A
R
E
A
G
A
D
C
A
V
A
V
G
G
G
S
T
T
G
L
G
K
A
I
A
---
L
E
--
T
G
-
M
P
-------------------------
I
V
A
I
P
T
T
YA
G
S
E
V
T
P
--
V
Y
G
L
T
E
A
G
T
K
R
T
G
R
D
P
R
V
L
P
R
T
V
I
Y
D
P
A
L
T
V
G
L
P
R
G
L
S
V
T
S
A
L
N
A
I
A
H
A
A
E
G
L
Y
A
---
R
DAN
P
V
---
M
S
L
----
M
A
E
E
G
---
I
R
A
L
A
A
G
I
P
A
V
F
N
----
D
P
A
D
L
D
A
R
S
Q
C
L
--
Y
G
A
W
--
L
C
G
T
V
L
G
G
V
-
G
-
M
A
L
-
H
----
H
K
L
C
H
T
L
G
G
S
F
N
L
P
H
A
E
T
H
T
I
V
L
P
H
A
L
A
Y
N
A
A
----
A
V
P
E
A
M
----
A
R
I
-
R
R
A
T
---
G
-
A
--
G
E
Q
S
A
A
A
T
L
F
---
D
L
A
Q
R
H
G
A
P
V
A
L
R
-
D
I
G
M
R
E
E
D
L
D
R
A
A
D
--------------------------------------