@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0292: (2015-11-30 )
MKESFKLIATAAAGLEAIVGREIRNLGIDCQVENGRVRFHGDIKTIIETNLWLRAADRIKIIVGEFPARTFEELFQGVYGLDWENYLPLGAKFPIAKAKCVKSKLHNEPSVQAISKKAVAKKLQKVFHRPEGVPLQENGAEFKIEVSILKDKATVMIDTTGSSLFKRGYRAEKGGAPIKENMAAAIIQLSNWFPDKPLIDPTCGSGTFCIEAAMIGMNIAPGFNRDFAFEAWPWVDQSQVQKVRDEAESKANYDIDLDISGFDLDGRMVEIARKNAEEAGLGDVIKLKQMRLQDLKTDKINGVIISNPPYGERLLDDKAVDILYNEMGQTFAPLKTWSKFILTSDEGFEKKYGSQADKKRKLYNGTLKVDLYQYYGERVRRQVK
Atome Classification :
(20 SA)
.........10........20..----...----.-.--.--30.----...------.....40.---------------.......50........60.....---------.---..---------70........80-........90........100.......110.......120.-......130-..--..---....140.......150.......160.-.......170.......180.......190.....--..200.......210.......220...-.-...230.......240.......250---..---...---..260.......270.......280.......290....--.-----.-.300--..---.......310.....---------------.------------.320----..----.....330-.-----......340.......---350-.---........360.--......370..----------.....380..--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
S
F
K
L
I
A
T
A
A
A
G
L
E
A
I
V
G
R
E
I
----
R
NL----G-
I
--
D
--
C
-
Q
----
V
EN------
G
R
V
R
FHGD---------------
I
K
T
I
I
ETN
L
W
L
R
AA
D
R
I
K
I
I
VGEF---------
P
---
A
R
---------
T
F
E
E
L
F
Q
G
V
YGL-DWENYLPLGAKFP
I
A
K
A
K
C
V
K
S
K
LHNEP
S
V
Q
A
I
S
K
K
A
V
A
K
K
L
-
Q
K
V
FHRPE--GV--PL---QENG
A
E
F
K
I
E
V
S
I
LKDK
A
T
V
M
I
DTT
G
-
S
-
S
L
F
K
RGYRAEKGGA
P
I
K
E
N
M
A
A
A
I
I
Q
L
SNWFPDKP--LIDPTCGSG
T
F
C
I
E
A
A
M
IGMNIAPGFNR-D-FAFEAWPWV
D
Q
S
Q
V
Q
K
V
R
D
E
A
ESKAN---
Y
D
---
I
D
L
---
D
I
SGFDLD
G
R
M
V
E
I
A
R
KN
A
E
EAGL
G
D
V
I
K
L
K
Q
M
R
L
Q
DLK--T-----D-KI----
N
G
---
V
I
ISNPPY
G
E
R
LLDD---------------
K
------------
A
V
D
I
----
L
Y
----
N
EMGQTFA-
P
-----
L
K
T
W
S
K
F
I
L
TSDEG
F
E
---
K
---K---YGS
Q
A
D
K
KRKLY--N
G
T
L
K
V
D
L
Y
Q
Y
----------
Y
G
E
R
V
R
R
QVK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
99.45
80%
-98
- C1 -
3LDG
1
?
A:
[1-380]
M
K
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
----
R
N
L
----
G
-
L
--
D
--
C
-
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
---------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
---------
P
---
A
R
---------
T
F
E
E
L
F
Q
G
V
Y
A
L
-
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
V
K
S
K
L
H
N
E
P
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
-
Q
H
Y
F
H
R
P
D
--
S
V
PL
P
E
-----
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
--
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
---
Y
D
---
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
K
--
T
-----
N
-
K
I
----
N
G
---
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
D
---------------
K
------------
A
V
D
I
----
L
Y
----
N
E
M
G
E
T
F
A
-
P
-----
L
K
T
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
---
F
G
R
K
A
D
K
K
R
K
L
Y
--
N
G
S
L
K
V
D
L
Y
Q
F
----------
Y
G
Q
R
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.04
77%
-97
- C1 -
3LDG
1
?
A:
[2-380]
-
K
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
----
R
N
L
----
G
-
L
--
D
--
C
-
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
---------------
I
E
T
I
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
---------
P
---
A
R
---------
T
F
E
E
L
F
Q
G
V
Y
A
L
-
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
V
K
S
K
L
H
N
E
P
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
-
Q
H
Y
F
H
R
P
D
--
S
V
--
P
L
---
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
--
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
-
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
---
Y
D
---
I
Q
L
---
D
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
K
--
T
-----
N
-
K
I
----
N
G
---
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
D
---------------
K
------------
A
V
D
I
----
L
Y
----
N
E
M
G
E
T
F
A
-
P
-----
L
K
T
W
S
Q
F
I
L
T
N
D
T
D
F
E
---
Q
---
K
---
F
G
R
K
A
D
K
K
R
K
L
Y
--
N
G
S
L
K
V
D
L
Y
Q
F
----------
Y
G
Q
R
V
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.17
54%
-95
- C1 -
3K0B
2
?
A:
[13-384]
--
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
----
A
R
L
----
G
-
Y
--
D
--
P
-
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
---------------
L
S
A
I
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
F
---------
K
---
A
T
---------
T
F
D
E
L
F
E
K
T
K
A
L
-
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
-
G
K
S
V
K
S
T
L
Y
S
V
P
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
-
S
E
K
Y
R
R
S
G
--
R
----
L
---
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
--
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
A
N
---
Y
D
---
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
Q
--
T
-----
E
-
D
E
----
Y
G
---
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
E
---------------
E
------------
A
V
R
Q
----
L
Y
----
R
E
M
G
I
V
Y
K
-
R
-----
M
P
T
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
---
Y
G
K
K
A
T
K
K
R
K
L
Y
------
R
T
D
L
Y
Q
Y
----------
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
89.63
55%
-94
- C1 -
3K0B
2
?
A:
[12-384]
-
M
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
----
A
R
L
----
G
-
Y
--
D
--
P
-
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
---------------
L
S
A
I
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
F
---------
K
---
A
T
---------
T
F
D
E
L
F
E
K
T
K
A
L
-
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
G
-
K
S
V
K
S
T
L
Y
S
V
P
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
-
S
E
K
Y
R
R
S
G
--
R
L
--
M
E
-----
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
--
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
-
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
A
N
---
Y
D
---
Q
P
L
---
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
Q
--
T
-----
E
-
D
E
----
Y
G
---
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
E
---------------
E
------------
A
V
R
Q
----
L
Y
----
R
E
M
G
I
V
Y
K
-
R
-----
M
P
T
W
S
V
Y
V
L
T
S
Y
E
L
F
E
---
E
---
V
---
Y
G
K
K
A
T
K
K
R
K
L
Y
------
R
T
D
L
Y
Q
Y
----------
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.91
44%
-83
- C1 -
3LDU
12
?
A:
[5-383]
--
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
----
T
N
L
----
G
-
Y
--
E
--
I
I
K
----
T
E
D
------
G
R
I
T
Y
K
T
D
---------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
---------
E
---
A
K
---------
S
F
D
E
L
F
E
N
T
K
R
I
-
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
K
A
S
S
I
K
S
K
L
Y
S
T
P
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
-
K
K
S
Y
L
--
E
--
D
G
--
L
L
---
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
--
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
K
I
D
---
N
E
---
S
K
F
---
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
K
--
S
-----
E
-
D
E
----
F
G
---
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
K
---------------
D
------------
S
V
K
Q
----
L
Y
----
K
E
L
G
Y
A
F
R
-
K
-----
L
K
N
W
S
Y
Y
L
I
T
S
Y
E
D
F
E
---
Y
---
E
---
F
G
Q
K
A
D
K
K
R
K
L
Y
--
N
G
M
L
K
T
N
F
F
Q
Y
----------
P
G
P
K
P
P
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
83.71
44%
-85
- C1 -
3LDU
12
?
A:
[5-383]
--
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
----
T
N
L
----
G
-
Y
--
E
I-
I
-
K
----
T
E
D
------
G
R
I
T
Y
K
T
D
---------------
E
F
G
I
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
---------
E
---
A
K
---------
S
F
D
E
L
F
E
N
T
K
R
I
-
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
K
A
S
S
I
K
S
K
L
Y
S
T
P
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
-
K
K
S
Y
L
E
D
G
--
L
L
--
K
E
-----
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
--
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
-
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
K
I
D
---
N
E
---
S
K
F
---
K
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
K
--
S
-----
E
-
D
E
----
F
G
---
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
K
---------------
D
------------
S
V
K
Q
----
L
Y
----
K
E
L
G
Y
A
F
R
-
K
-----
L
K
N
W
S
Y
Y
L
I
T
S
Y
E
D
F
E
---
Y
---
E
---
F
G
Q
K
A
D
K
K
R
K
L
Y
--
N
G
M
L
K
T
N
F
F
Q
Y
----------
P
G
P
K
P
P
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
76.58
32%
-70
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
--
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
----
E
N
L
----
G
A
V
--
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
---------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
---------
K
---
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
A
I
-
N
W
T
E
M
F
N
P
G
A
T
F
A
V
-
H
F
S
G
L
N
D
T
I
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
-
T
R
K
N
L
P
R
P
--
N
V
-------
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
--
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
---
K
G
---
L
A
E
YS
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
--
N
-----
P
-
L
P
----
K
G
P
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
E
---------------
P
------------
A
L
I
A
----
L
H
----
S
L
L
G
R
I
M
K
-
N
Q----
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
--
N
G
P
L
D
C
V
Q
K
N
Y
H
V
A
E
SMVA
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
GIECYRLYDADLPEYN
V
A
V
D
R
Y
AD
W
V
V
V
Q
E
Y
AH
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIAPNK
L
V
L
K
T
REE
K
G
E
F
L
E
V
T
E
YN
A
H
L
W
V
N
LTDYLDTGLFLDH
R
I
A
R
R
M
L
G
Q
M
SKGKD
F
L
N
L
FSYTG
S
A
T
V
H
A
G
L
G
GAR
S
T
T
T
V
D
MS
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
GLTGRA
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
ANEQFD
L
I
F
I
D
P
P
TFSAFDVQRD
H
L
A
L
M
K
D
L
K
R
L
LRAG
G
T
I
M
F
S
N
NKRGFRMD
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
27
HHSearch
76.46
32%
-66
- C1 -
3V97
3
RLMKL_ECOLI
A:
[1-383]
--
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
----
E
N
L
----
G
-
A
--
V
E-
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
---------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
---------
K
---
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
A
I
-
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
F
-
S
G
L
N
D
T
I
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
-
T
R
K
N
L
P
R
P
--
N
V
--
D
R
-----
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
--
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
-
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
---
K
G
L
A
E
Y
S
S
---
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
--
N
PLP--
K
-
G
P
----
Y
G
---
T
V
L
S
N
P
P
Y
G
E
---
S
E
---------------
P
------------
A
L
I
A
----
L
H
----
S
L
L
G
R
I
M
K
N
Q
-----
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
--
N
G
P
L
D
C
V
Q
K
N
Y
----------
H
V
A
E
S
M
V
A
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_CBE
71.38
31%
-71
- C1 -
3V97
3
RLMKL_ECOLI
B:
[26-379]
----------------------------------
A
-
V
--
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
---------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
---------
K
---
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
A
I
-
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
--------
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
-
R
---
P
R
P
N
-------
V
---
D
R
D
A
P
D
I
R
V
N
V
W
------
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
---
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
--
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
---
Y
S
S
---
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
---
T
-----
N
-
P
L
PKGP
Y
G
---
T
V
L
S
N
P
P
Y
-----
S
E
---------------
P
------------
A
L
I
A
----
L
H
----
S
L
L
G
R
I
M
K
N
Q
-----
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
--
N
G
P
L
D
C
V
Q
K
N
Y
----------
H
V
A
E
S
E
D
Y
T
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_CBE
71.16
31%
-74
- C1 -
3V8V
2
RLMKL_ECOLI
B:
[25-378]
----------------------------------
A
-
V
--
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
---------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
--------------
Y
---------
S
D
L
D
L
Y
L
G
V
Q
A
I
-
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
--------
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
-
R
---
P
R
P
N
-------
V
---
D
R
D
A
P
D
I
R
V
N
V
W
-------
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
----
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
--
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
---
Y
S
S
---
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
---
T
-----
N
-
P
L
PK
G
P
Y
G
---
T
V
L
S
N
P
P
Y
-----
S
E
---------------
P
------------
A
L
I
A
----
L
H
----
S
L
L
G
R
I
M
K
N
Q
-----
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
--
N
G
P
L
D
C
V
Q
K
N
Y
----------
H
V
A
E
S
E
D
Y
T
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.94
31%
-59
- C1 -
3V97
3
RLMKL_ECOLI
A:
[26-379]
----------------------------------
A
-
V
--
E
--
C
-
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
---------------
T
R
L
V
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
---------
K
---
V
Y
---------
S
D
L
D
L
Y
L
G
V
Q
A
I
-
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
F
S
G
L
N
D
T
I
R
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
-
R
K
N
L
P
R
P
N
-------
V
---
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
--
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
-
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
---
Y
S
S
---
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
---
T
-----
N
-
P
L
PKGP
Y
G
---
T
V
L
S
N
P
P
Y
G
E
---
S
E
---------------
P
------------
A
L
I
A
----
L
H
----
S
L
L
G
R
I
M
K
N
Q
-----
F
G
G
W
N
L
S
L
F
S
A
S
P
D
L
L
---
S
---
C
---
L
Q
L
R
A
D
K
Q
Y
K
A
K
--
N
G
P
L
D
C
V
Q
K
N
Y
----------
H
V
A
E
S
M
V
A
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
68.33
26%
-73
- C1 -
3TM4
1
?
A:
[1-370]
----
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
----
S
L
L
L
K
K
L
G
-
I
--
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
--
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
FNGIEKDE
S
---
E
E
---------
A
L
K
R
I
K
D
F
V
S
S
L
-
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
-
R
S
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
-
S
----
R
F
G
--
T
P
--
L
V
---
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
--
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
G
-------------------------------------------------
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q-
Y
-----
V
-
D
S
----
V
D
---
F
A
I
S
N
L
P
Y
G
S
M
--
I
P
---------------
D
------------
L
Y
M
K
----
F
F
----
N
E
L
A
K
V
---------
L
E
K
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
A
I
A
E
---
N
G
F
E
I
I
H
H
R
V
I
G
--
H
G
G
L
M
V
H
L
Y
V
V
----------
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.26
25%
-62
- C1 -
3TM4
1
?
A:
[1-362]
----
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
--
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
---------
N
---
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
F
R
K
G
D
H
N
I
T
S
I
D
---
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
--
P
L
V
N
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
--
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
------
I
E
K
Y
R
K
H
--------------------------
L
I
G
-----
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
QY
V
-----
D
-
S
V
----
D
----
F
A
I
S
N
L
P
Y
G
---------------------
S
------------
M
I
P
D
----
L
Y
M
K
F
F
N
E
L
A
K
V
---------
L
E
K
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
A
I
A
E
---
N
G
F
E
I
I
H
H
R
V
I
G
--
H
G
G
L
M
V
H
L
Y
V
V
----------
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
63.59
26%
-69
- C1 -
3TM4
1
?
A:
[1-365]
----
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
----
S
L
L
L
K
K
L
G
-
I
--
S
F
Q
I
-
E
E
KPL
G
I
E
------
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
--
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
---------
K
---
F
N
GIEKDE
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
-
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
-
F
R
K
G
D
H
N
I
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
-
S
R
F
-
G
-
T
P
--
L
V
--
N
L
-----
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
-
D
S
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
-
D
G
G
S
--
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
----------------------------------------------
S
G
---
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
--
Q
-----
Y
V
D
S
----
V
D
---
F
A
I
S
N
L
P
Y
G
---------------------
S
------------
M
I
P
D
L
Y
M
K
F
F
----
N
E
L
A
K
V
L
E
--------
K
R
G
V
F
I
T
-
T
E
K
K
A
I
E
E
A
I
A
---
E
---
N
G
F
E
I
I
H
H
R
V
I
G
--
H
G
G
L
M
V
H
L
Y
V
V
----------
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.65
25%
-64
- C1 -
3TLJ
2
?
A:
[1-362]
----
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
--
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
---------
N
---
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
F
R
K
G
D
H
N
I
T
S
I
D
---
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
--
P
L
V
N
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
--
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
------
I
E
K
Y
R
K
H
--------------------------
L
I
G
-----
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
QY
V
-----
D
-
S
V
----
D
----
F
A
I
S
N
L
P
Y
G
---------------------
S
------------
M
I
P
D
----
L
Y
M
K
F
F
N
E
L
A
K
V
---------
L
E
K
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
A
I
A
E
---
N
G
F
E
I
I
H
H
R
V
I
G
--
H
G
G
L
M
V
H
L
Y
V
V
----------
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.51
25%
-64
- C1 -
3TM5
1
?
A:
[1-362]
----
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
----
G
-
I
--
S
--
F
-
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
F
---------
N
---
G
I
---------
E
K
D
E
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
S
F
R
K
G
D
H
N
I
T
S
I
D
---
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
G
T
--
P
L
V
N
L
D
H
P
A
V
I
F
R
A
E
--
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
-
L
D
G
G
S
--
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
----------
R
-
R
-
Y
S
G
E
I
I
G
------
I
E
K
Y
R
K
H
--------------------------
L
I
G
-----
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
QY
V
-----
D
-
S
V
----
D
----
F
A
I
S
N
L
P
Y
G
L
K
I
G
-
K
---------------
S
------------
M
I
P
D
----
L
Y
M
K
F
F
N
E
L
A
K
V
---------
L
E
K
R
G
V
F
I
T
T
E
K
K
A
I
E
---
E
A
I
A
E
---
N
G
F
E
I
I
H
H
R
V
I
G
--
H
G
G
L
M
V
H
L
Y
V
V
----------
K
L
E
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
53.41
21%
-56
* C1 *
3TMA
1
?
A:
[19-352]
---
H
M
W
L
E
A
T
T
H
P
G
L
E
D
L
L
L
E
E
L
----
S
A
L
----
Y
P
G
E
G
A
E-
V
-
D
----
A
R
K
------
G
R
V
R
I
P
R
A
---------------
W
V
--
G
E
E
A
L
G
L
R
L
A
H
H
L
V
L
F
R
A
R
L
---------
L
LSR
E
D
---------
P
L
G
A
L
E
R
A
A
L
A
L
-
P
W
P
E
L
E
G
-
A
G
S
F
R
V
E
A
-
R
R
E
G
E
H
P
F
T
S
P
E
V
E
R
R
V
G
E
A
L
H
R
A
Y
-----
G
--
V
--
P
V
--
D
L
-----
K
R
P
A
V
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
F
P
K
-
A
A
L
R
G
S
L
T
P
V
L
A
Q
A
L
L
R
L
A
D
A
R
P
G
M
R
--
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
---------------------------------------------
P
T
S
---
P
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
L
S
-
W
I
R
F
L
R
A
D
A
R
H
L
P
--
R
-----
F
F
P
E
----
V
D
---
R
I
L
A
N
P
P
H
G
L
----
K
---------------
E
------------
G
L
F
H
L
Y
W
D
F
L
----
R
G
A
L
A
L
L
P
--------
P
G
G
R
V
A
L
L
T
L
R
P
A
L
L
---
K
---
R
A
LP
P
G
F
A
L
R
H
A
R
V
V
E
--
Q
G
G
V
Y
P
R
V
F
V
L
----------
E
K
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
44.17
24%
-62
- C1 -
1NV8
2
PRMC_THEMA
A:
[104-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
P
E
T
E
E
L
V
E
L
A
L
E
L
I
R
K
Y
G
I
K
T
--
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-----------------------------------------------
D
A
---
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
G
V
S
D
R
F
F
V
R
K
G
E
F
L
E
P
F
--
K
EK---
F
-
A
S
----
I
E
---
M
I
L
S
N
P
P
Y
V
K
S
S
A
H
L
PKDVLFEPPEALFGG
E
------------
D
G
L
D
----
F
Y
----
R
E
F
F
G
R
Y
D
--------
T
S
G
K
I
V
L
M
E
I
G
E
D
Q
V
---
E
---
E
---
L
K
K
I
V
S
D
T
V
F
L
K
--
D
S
A
G
K
Y
R
F
L
L
L
----------
N
R
R
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
43.24
13%
-68
- C1 -
3UFB
-
?
A:
[197-367]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
D
P
Q
L
G
E
S
--
V
L
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
C
K
T
----------------
V
E
D
R
-----------
E
---
V
L
---
Q
E
S
---
S
I
F
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
N
L
L
L
H
G
L
E
Y
-
P
R
I
D
P
E
N
S
L
R
F
P
--
L
REMGD
K
-
D
R
----
V
D
---
V
I
L
T
N
P
P
F
G
G
E
E
E
K
G
---------------
I
L
G
N
F
PEDMQTAE
T
A
M
L
----
F
L
----
Q
L
I
M
R
K
L
K
-
R
PGHGS
D
N
G
G
R
A
A
V
V
V
P
N
G
T
L
F
---
S
---
D
---
G
I
S
A
R
I
K
E
E
L
L
K
--
N
F
N
L
H
T
I
V
R
L
P
----------
E
G
V
F
A
P
Y
T
D
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
40.61
18%
-33
- C1 -
1T43
1
PRMC_ECOLI
A:
[2-275]
--
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
-------------------------------------------------------------------------------------
E
S
---------
P
---
R
R
---------
D
A
E
I
L
L
E
H
V
T
G
R
-
G
R
T
F
I
L
A
--------------------
F
G
E
T
Q
L
T
D
E
Q
C
Q
Q
L
D
-
A
L
L
T
R
R
R
D
--
G
E
--
P
--------------
I
A
H
L
T
G
V
R
E
-----------
F
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
P
D
T
E
C
L
V
E
Q
A
L
A
R
L
P
E
Q
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C
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I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
----------------------------------------------
C
---
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
A
I
K
N
I
H
I
L
Q
S
D
W
F
S
A
L
A
--
G
-----
Q
-
Q
F
----
A
----
M
I
V
S
N
P
P
Y
--------------------------------------
I
----
D
E
----
Q
D
P
H
L
Q
Q
G
-
D
-----
V
R
F
E
P
L
T
A
L
V
A
A
D
S
G
M
---
A
---
D
---
I
V
H
I
I
E
Q
S
R
N
A
L
VS
G
G
F
L
L
L
E
H
G
W
Q
----------
Q
G
E
A
V
R
Q
A
F
I
L
A
GY
H
D
V
E
T
C
R
D
Y
GDNER
V
T
L
G
R
Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------