@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1447: (2015-12-08 )
MRYLTAGESHGPSLTAIIEGIPAGLKLSAKDINEDLKRRQGGYGRGNRMKIETDQVIISSGVRHGKTLGSPITLTVTNKDHSKWLDIMSVEDIEERLKQKRRIKHPRPGHADLVGGIKYRFDDLRNALERSSARETTMRVAIGAIAKRILKEIGIEIANHIVVFGGKEITVPDKLTVQQIKVLSSQSQVAIVNPSFEQEIKDYIDSVKKAGDTIGGVIETIVGGVPVGLGSYVHWDRKLDAKIAQAVVSINAFKGVEFGLGFKSGFLKGSQVMDSISWTKDQGYIRQSNNLGGFEGGMTNGEPIIVRGVMKPIPTLYKPLMSVDIDTHEPYRATVERSDPTALPAAGVVMEAVVATVLVTEVLEKFSSDNMYELKEAVKLYRNYVNHF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........-90.....----..---.100....-...110.......120.......130.......140.......150-.......160...----....170...----....------180-.......190.......200.......210.....-------..220.------......230.......240.......250.......260.......270.......280....-...290.......300.......310.......320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
Y
L
TAGESHG
P
S
L
T
A
I
I
E
GIPAG
L
K
L
S
A
K
D
I
N
E
D
L
K
R
RQGGYGRGN
R
M
K
I
ETD
Q
V
I
I
S
SGVRHGKTLGS
P
I
T
L
T
V
TNKDH
S
K
W
L
D
IM
S
-
V
E
D
I
E
E
R
----
L
K
---
Q
K
RRIKHP-RPGH
A
D
L
VG
G
I
K
Y
R
F
D
D
L
R
N
A
L
E
R
SSAR
E
T
T
M
R
V
A
I
G
A
I
A
K
R
I
L
K
E
-
I
G
I
E
I
A
N
H
I
V
V
FG----G
K
E
ITVPD
K
L
----
T
V
Q
Q
------
I
K
V
-LSSQS
Q
V
A
I
VNP
S
F
E
Q
E
I
K
D
Y
I
D
S
V
K
K
AGDT
I
G
G
V
-------
I
E
T
I
VG------GVPVGLGS
Y
V
HWDR
K
L
D
A
K
I
A
Q
A
V
V
S
I
N
AFK
G
V
E
F
GLG
F
K
SGFLK
G
S
Q
V
M
D
S
ISWTKDQ
G
Y
I
R-QSNNLGGFEGGMTNG
E
P
I
I
V
R
G
V
MKP
I
P
T
L
Y
K
P
L
M
SVDIDTHEP
Y
R
A
TVERSDPTAL
P
A
A
G
V
V
M
E
A
V
V
A
T
V
L
V
T
E
V
L
E
K
FSSD
N
M
Y
E
L
K
E
A
V
K
L
Y
R
N
Y
V
NHF
25
HHSearch
96.90
79%
-90
- C7 -
1QXO
9
AROC_STRPN
A:
[1-388]
M
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
Q
K
W
L
D
I
M
S
-
A
E
D
I
E
D
R
----
L
K
---
S
K
R
K
I
T
H
P
-
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
----
G
K
E
I
D
V
P
E
N
L
----
T
V
A
E
------
I
K
Q
-
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
-------
V
E
T
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
S
K
E
D
G
Y
T
R
-
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
D
Y
T
K
N
Y
1
PsiBlast_PDB
95.57
76%
-89
- C7 -
1QXO
9
AROC_STRPN
A:
[2-388]
-
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
K
D
H
Q
K
W
L
D
I
M
S
-
A
E
D
I
E
D
R
----
L
K
---
S
K
R
K
I
T
H
P
-
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
----
G
K
E
I
D
V
P
E
N
L
----
T
V
A
E
------
I
K
Q
-
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
-------
V
E
T
V
V
G
------
G
V
P
V
G
L
G
S
Y
V
Q
W
D
R
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
S
K
E
D
G
Y
T
R
-
R
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
R
D
Y
T
K
N
Y
5
PsiBlast_PDB
80.87
41%
-78
- C7 -
2O12
7
AROC_MYCTU
A:
[2-389]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
-
A
D
P
V
D
P
A
E
L
A
D
V
A
---
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
----
R
A
E
D
------
L
P
A
-
I
D
A
-
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
-
Y
P
G
P
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
4
PsiBlast_PDB
80.85
41%
-77
- C7 -
2O11
7
AROC_MYCTU
A:
[2-389]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
---------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
-
A
D
P
V
D
P
A
E
L
A
D
V
A
---
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
----
R
A
E
D
------
L
P
A
-
I
D
A
-
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
-
Y
P
G
P
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
6
PsiBlast_PDB
80.47
41%
-73
- C7 -
2QHF
17
AROC_MYCTU
A:
[2-389]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
R
M
T
F
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
-
A
D
P
V
D
P
A
E
L
A
D
V
A
---
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
----
R
A
E
D
------
L
P
A
-
I
D
A
-
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
-
Y
P
G
P
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
3
PsiBlast_PDB
79.57
41%
-78
- C7 -
2G85
-
AROC_MYCTU
A:
[2-389]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
------
F
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
-
A
D
P
V
D
P
A
E
L
A
D
V
A
---
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
----
R
A
E
D
------
L
P
A
-
I
D
A
-
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
-
Y
P
G
P
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
27
HHSearch
79.50
42%
-72
- C7 -
2O11
7
AROC_MYCTU
A:
[2-391]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
---------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
A
D
P
V
D
P
A
E
----
L
A
D
VA
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
-----
R
A
E
------
D
L
P
-
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
Y
P
G
P
-
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
2
PsiBlast_PDB
79.10
41%
-69
- C7 -
1ZTB
-
AROC_MYCTU
A:
[2-389]
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
L
G
Y
G
R
G
A
----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
G
N
T
E
W
P
K
W
E
T
V
M
A
-
A
D
P
V
D
P
A
E
L
A
D
V
A
---
R
N
A
P
L
T
R
P
-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
----
A
S
A
P
Y
E
G
P
P
P
----
R
A
E
D
------
L
P
A
-
I
D
A
-
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
-------
V
E
A
V
A
L
------
G
L
P
V
G
L
G
S
F
T
S
G
D
H
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
E
M
-
Y
P
G
P
D
G
V
V
R
-
S
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
D
S
L
A
E
T
Q
R
N
I
A
A
Y
Q
R
S
V
A
D
R
13
PsiBlast_PDB
77.75
32%
-96
- C7 -
1SQ1
2
AROC_CAMJE
A:
[8-360]
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
---------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
--------
T
F
V
S
N
L
----
K
E
E
E
------
F
D
F
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
-------
V
F
T
K
V
S
------
G
M
L
I
G
L
G
E
-
V
L
Y
D
-
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
---
K
D
G
K
F
L
---
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
---------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
-
A
S
A
N
L
N
N
L
K
N
A
Y
G
---------
28
HHSearch
76.14
33%
-93
- C7 -
1R53
-
AROC_YEAST
A:
[8-371]
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
R
P
------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
K
N
----------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
E
K
F
L
A
Q
N
S
N
V
E
I
V
A
F
V
T
Q
I
G
----
E
I
K
M
N
R
D
S
F
D
P
---
E
F
Q
H
L
L
N
TIT
R
E
K
-
V
D
S
M
G
P
I
R
C
P
D
A
S
V
A
G
L
M
V
K
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
-------
V
T
C
V
V
R
------
N
L
P
T
G
L
G
E
P
--
C
F
D
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
P
F
Y
-------
R
T
-
K
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
-----------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
I
Q
K
A
R
D
F
S
-----------------
12
PsiBlast_PDB
76.10
32%
-93
- C7 -
1R53
-
AROC_YEAST
A:
[8-363]
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
R
P
------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
K
N
----------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
E
K
F
L
A
Q
N
S
N
V
E
I
V
A
F
V
T
Q
I
G
EIKM
N
R
D
S
F
D
P
E
F
Q
H
L
L
N
T
I
T
R
------
E
K
V
--
D
S
M
G
P
I
R
C
P
D
A
S
V
A
G
L
M
V
K
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
-------
V
T
C
V
V
R
------
N
L
P
T
G
L
G
E
P
C
-
F
D
-
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
P
F
Y
--------
R
T
K
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
-----------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
I
Q
K
A
R
D
F
S
-----------------
29
HHSearch
74.45
32%
-95
- C7 -
1SQ1
2
AROC_CAMJE
A:
[8-353]
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
F
---------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
----
T
F
V
S
N
L
K
E
E
-------
E
F
------
D
F
E
-
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
-------
V
F
T
K
V
S
------
G
M
L
I
G
L
G
E
V
--
L
Y
D
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
A
L
K
D
G
-----
K
F
-
L
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
---------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
N
L
N
N
L
K
N
A
Y
G
----------
30
HHSearch
73.97
37%
-67
* C7 *
1UM0
2
AROC_HELPY
A:
[8-357]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
R
---
A
------
R
S
K
D
Y
------------
D
N
I
K
N
L
F
-
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
-
G
G
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
----
G
I
K
A
K
N
Y
D
F
-----------------
N
-
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
-------
A
L
I
R
A
R
S
IKTNQ
K
L
P
I
G
L
G
Q
G
--
L
Y
A
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
L
M
D
Q
K
-----
G
F
-
L
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
N
--------
7
PsiBlast_PDB
73.13
35%
-67
- C7 -
1UM0
2
AROC_HELPY
A:
[8-357]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
---------------
R
A
R
----
S
K
---
D
Y
D
N
I
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
----
G
--
I
K
A
K
N
Y
D
----
F
N
H
A
------
L
K
------
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
-
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
---
L
M
D
Q
K
G
F
L
---
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
N
--------
8
PsiBlast_PDB
72.75
35%
-65
- C7 -
1UMF
-
AROC_HELPY
A:
[8-357]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
---------------
R
A
R
----
S
K
---
D
Y
D
N
I
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
----
G
--
I
K
A
K
N
Y
D
----
F
N
H
A
------
L
K
------
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
-
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
---
L
M
D
Q
K
G
F
L
---
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
N
--------
24
PsiBlast_CBE
72.60
36%
-90
- C7 -
4O90
2
?
B:
[10-345]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
----------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
----
N
E
---
V
A
E
K
L
----
D
W
N
E
------
V
P
N
-
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
----
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
-------
L
E
I
L
A
E
------
K
V
P
V
G
W
G
E
P
V
-
F
D
R
-
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
---
S
H
G
F
L
---
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
-------------------
11
PsiBlast_PDB
72.55
36%
-85
- C7 -
4OB9
-
?
A:
[10-345]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
-
K
---------------------------------------------------
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
----
N
E
---
V
A
E
K
L
----
D
W
N
E
------
V
P
N
-
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
----
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
-------
L
E
I
L
A
E
------
K
V
P
V
G
W
G
E
P
V
-
F
D
R
-
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
---
S
H
G
F
L
---
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
--------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
-------
10
PsiBlast_PDB
72.36
36%
-87
- C7 -
4O90
1
?
A:
[10-345]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
----------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
----
N
E
---
V
A
E
K
L
----
D
W
N
E
------
V
P
N
-
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
----
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
-------
L
E
I
L
A
E
------
K
V
P
V
G
W
G
E
P
V
-
F
D
R
-
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
---
S
H
G
F
L
---
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
-------------------
22
PsiBlast_CBE
72.17
35%
-64
- C7 -
1UM0
2
AROC_HELPY
C:
[8-357]
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
H
N
Q
---------------
R
A
R
----
S
K
---
D
Y
D
N
I
K
N
L
F
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
----
G
--
I
K
A
K
N
Y
D
----
F
N
H
A
------
L
K
------
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
ALIRARS
I
K
T
-
N
Q
------
K
L
P
I
G
L
G
Q
G
L
Y
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
---
L
M
D
Q
K
G
F
L
---
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
K
I
E
Y
L
K
T
I
Y
N
E
N
--------
9
PsiBlast_PDB
71.88
36%
-82
- C7 -
4LJ2
-
?
A:
[10-345]
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
R
N
T
D
Q
-
K
S
K
---------------------------------------------
R
D
Y
R
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
----
N
E
---
V
A
E
K
L
----
D
W
N
E
------
V
P
N
-
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
----
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
-------
L
E
I
L
A
E
------
K
V
P
V
G
W
G
E
P
V
-
F
D
R
-
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
E
L
T
---
S
H
G
F
L
---
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
S
I
T
-----------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
N
A
D
V
V
P
P
F
A
P
I
E
P
-------