@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3290c: (2016-05-18 )
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
Atome Classification :
(31 SA)
----.........10........20........30.....----...40.---....------------...-50.-.--......60........70........80........90........100.......110--.-...---...-..120.......130.......140---..-.....150-------------.......---.160.......170.......180.......190.......200.-.......--210.....-----..220.....---.---.230..-.....-240........250.......260.......270.......280......--.290--....----..-----.300.----..----..-.-.310........320.........330.......340.......350--........-.360.......370.......380.......390.-...-.--.-----------.-400------.........410....--.--.--.420.......430.......440.......------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
A
A
V
V
K
S
V
ALAGRPT
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
TRS---GG
S
Y
------------
L
V
D
-
A
IT-G--R
R
Y
L
D
M
F
T
F
V
A
S
SALGMNPPALVD
D
R
E
F
H
A
E
L
M
Q
A
A
LNKPSNS
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L---GDP-AL
P
H
L
F
F
VEG
G
A
L
A
V
E
N
A
L
K
A
A
FDW---KS-RHNQAHG--------------ID
P
A
LG
T
---
Q
V
L
H
L
R
G
AFHGRS
G
Y
T
L
SLTNTK
P
T
I
T
ARFPKFDWPRID
A
P
Y-MR-PGLD
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
FET---R---PH
D
I
A
C
-
F
VAEP-I-QGEGGDRHF
R
P
E
F
F
A
A
M
R
E
L
C
D
EF
D
A
L
L
I
F
DEVQTGCGLTG
T
A
W
A
Y
Q
Q--LDVA--
P
D
I
V
----AF-----GKKT
Q
----
V
C
----
G
V
-M-AG-R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
LNSTWGG
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A----E
G
L
F
E
R
A
V
-QH
G
K
Y
L
R
A
R
L
D
E
L
A
ADF
P
A
V
V
LDPRG
R
G
L
M
C
A
FSL-PTT-A--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
QR
A
V
I
V
L
PA--G--A--
D
T
V
R
FRPP
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
SALPVVT------
2
PsiBlast_PDB
99.57
100%
-113
- C2 -
2CJG
1
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
5
PsiBlast_PDB
99.41
100%
-113
- C2 -
2CJD
1
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
1
PsiBlast_PDB
99.24
100%
-113
- C2 -
2CIN
1
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
3
PsiBlast_PDB
98.82
100%
-112
- C2 -
2CJH
2
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
4
PsiBlast_PDB
98.42
100%
-114
- C2 -
2JJG
2
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
7
PsiBlast_PDB
97.96
99%
-113
- C2 -
2JJH
2
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
A
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
6
PsiBlast_PDB
97.88
99%
-113
- C2 -
2JJE
1
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
S
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
8
PsiBlast_PDB
96.81
99%
-111
- C2 -
2JJF
-
LAT_MYCTU
A:
[15-449]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
-
A
I
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
V
Y
S
V
A
M
A
R
F
V
E
T
F
----
A
-
R
V
L
---
G
D
P
-
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
A
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
T
------
77
HHSearch
94.65
96%
-109
- C2 -
2CJG
1
LAT_MYCTU
A:
[15-448]
------------------
T
T
P
D
R
V
H
E
V
L
G
R
S
M
L
V
D
G
L
D
I
V
----
L
D
L
T
R
S
---
G
G
S
Y
------------
L
V
D
A
I
-
T
-
G
--
R
R
Y
L
D
M
F
T
F
V
A
S
S
A
L
G
M
N
P
P
A
L
V
D
D
R
E
F
H
A
E
L
M
Q
A
A
L
N
K
P
S
N
S
D
-
V
Y
S
V
A
M
A
R
F
V
E
T
----
F
-
A
R
V
---
L
G
D
P
A
L
P
H
L
F
F
V
E
G
G
A
L
A
V
E
N
A
L
K
A
A
F
D
W
---
K
S
-
R
H
N
Q
A
H
G
--------------
I
D
P
A
L
G
T
---
Q
V
L
H
L
R
G
A
F
H
G
R
S
G
Y
T
L
S
L
T
N
T
K
P
T
I
T
A
R
F
P
K
F
D
W
P
R
I
D
A
P
Y
-
M
R
-
P
G
L
D
E
P
A
--
M
A
A
L
E
A
E
A
-----
L
R
Q
A
R
A
A
F
E
T
---
R
---
P
H
D
I
A
C
-
F
V
A
E
P
-
I
-
Q
G
E
G
G
D
R
H
F
R
P
E
F
F
A
A
M
R
E
L
C
D
E
F
D
A
L
L
I
F
D
E
V
Q
T
G
C
G
L
T
G
T
A
W
A
Y
Q
Q
--
L
D
V
A
--
P
D
I
V
----
A
F
-----
G
K
K
T
Q
----
V
C
----
G
V
-
M
-
A
G
-
R
R
V
D
E
V
A
D
N
V
--
F
A
V
P
S
R
L
N
S
T
W
G
G
N
L
T
D
M
V
R
A
R
R
I
L
E
V
I
E
A
----
E
G
L
F
E
R
A
V
-
Q
H
G
K
Y
L
R
A
R
L
D
E
L
A
A
D
F
P
A
V
V
L
D
P
R
G
R
G
L
M
C
A
F
S
L
-
P
T
T
-
A
--
D
-----------
R
-
D
--------
E
L
I
R
Q
L
W
Q
R
A
V
I
V
L
P
A
--
G
--
A
--
D
T
V
R
F
R
P
P
L
T
V
S
T
A
E
I
D
A
A
I
A
A
V
R
S
A
L
P
V
V
-------
89
HHSearch
59.64
27%
-99
- C2 -
4JF1
9
ARGD_SALTY
A:
[37-418]
------------------------------------
A
P
A
D
----
F
I
P
V
K
G
---
K
G
S
R
------------
V
W
D
-
Q
-
Q
-
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
-
S
-
N
V
----
F
T
N
E
P
A
L
R
L
G
R
K
----
L
-
I
D
A
---
T
---
F
A
E
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
-
V
R
H
S
P
--------------------
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
Y
S
D
-
G
F
G
P
K
P
A
D
I
I
H
V
-------
P
F
------------
N
D
-----
L
H
A
V
K
A
V
M
D
---------
D
H
T
C
A
-
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
----
T
S
-----
A
K
A
L
G
----
G
G
F
P
V
-
S
A
-
M
-
L
T
T
Q
E
I
A
S
A
F
-------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
----
P
E
V
L
Q
G
I
H
-
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
-
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-
K
P
K
-
Y
KG
R
-----------
A
-
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
-------
100
Fugue
58.47
29%
-95
- C2 -
4UOX
9
PAT_ECOLI
A:
[7-459]
SAS
A
L
A
C
S
A
H
A
L
N
L
I
E
K
R
T
L
D
H
E
E
M
K
A
L
N
R
E
V
I
E
Y
F
K
E
H
V
N
P
G
F
L
E
Y
R
K
S
V
TA
G
G
D
Y
G
A
V
E
W
Q
AGSLN
T
L
V
D
-
T
-
Q
-
G
--
Q
E
F
I
D
C
L
G
G
F
G
I
F
N
V
G
H
R
N
P
V
V
V
S
A
V
Q
N
Q
L
A
K
------
Q
P
L
H
S
Q
E
L
L
D
P
L
R
A
M
L
A
K
T
----
L
-
A
A
L
---
T
P
G
-
K
L
K
Y
S
F
F
C
N
S
G
T
E
S
V
E
A
A
L
K
L
A
K
A
Y
---
Q
S
-
P
R
G
K
F
--------------------------
T
F
I
A
T
S
G
A
F
H
G
K
S
L
G
A
L
S
A
T
A
K
S
T
F
R
K
P
F
M
P
------------
L
L
-
P
G
F
R
H
V
P
--
F
G
--
N
I
E
A
-----
M
R
T
A
L
N
E
C
K
K
---
T
---
G
D
D
V
A
A
-
V
I
L
E
P
-
I
-
Q
G
E
G
G
V
I
L
P
P
P
G
Y
L
T
A
V
R
K
L
C
D
E
F
G
A
L
M
I
L
D
E
V
Q
T
G
M
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
--
P
D
I
L
----
C
L
A
KALG
G
G
V
M
P
----
I
G
----
A
T
-
I
-
A
T
-
E
E
V
F
S
V
L
-----
F
D
N
P
F
L
H
T
T
T
F
G
G
N
P
L
A
C
A
A
A
L
A
T
I
N
V
L
L
E
----
Q
N
L
P
A
Q
A
E
-
Q
K
G
D
M
L
L
D
G
F
R
Q
L
A
R
E
Y
P
D
L
V
Q
E
A
R
G
K
G
M
L
M
A
I
E
F
-
V
D
N
-
E
--
I
-----------
G
-
Y
--------
N
F
A
S
E
M
F
R
Q
R
V
L
V
A
G
T
LN
N
--
A
--
K
T
I
R
I
E
P
P
L
T
L
T
I
E
Q
C
E
L
V
I
K
A
A
R
K
A
L
A
A
M
R
V
S
V
E
EA
76
HHSearch
57.76
26%
-86
- C2 -
4Y0H
3
GABT_PIG
A:
[13-462]
--------------
V
P
G
P
R
S
R
E
L
-
M
K
Q
L
N
I
I
Q
N
A
E
A
V
H
F
F
----
C
N
Y
E
E
S
---
R
G
N
Y
------------
L
V
D
-
V
-
D
-
G
--
N
R
M
L
D
L
Y
S
Q
I
S
S
I
P
I
G
Y
S
H
P
A
L
V
K
L
V
Q
Q
P
Q
N
V
-
S
T
F
I
N
R
P
A
L
G
I
L
P
P
E
N
F
V
E
K
L
R
E
S
----
L
-
L
S
V
---
A
P
K
-
G
M
S
Q
L
I
T
M
A
C
G
S
C
S
N
E
N
A
F
K
T
I
F
M
W
---
Y
R
-
S
K
E
R
G
E
S
AFS
K
E
E
L
E
T
C
M
I
NQ
A
P
G
C
P
D
Y
---
S
I
L
S
F
M
G
A
F
H
G
R
T
M
G
C
L
A
T
T
H
S
K
A
I
H
K
I
D
I
P
S
F
D
W
P
I
A
P
F
P
R
-
L
K
-
Y
P
L
E
E
F
V
K
E
N
Q
Q
E
E
A
R
C
-----
L
E
E
V
E
D
L
I
V
K
---
Y
R
K
K
K
K
T
V
A
G
-
I
I
V
E
P
-
I
-
Q
S
E
G
G
D
N
H
A
S
D
D
F
F
R
K
L
R
D
I
S
R
K
H
G
C
A
F
L
V
D
E
V
Q
T
G
G
G
S
T
G
K
F
W
A
H
E
H
--
W
G
L
D
DP
A
D
V
M
----
T
F
-----
S
K
K
M
M
----
T
G
----
G
F
-
F
-
H
K
-
E
E
F
R
P
--------
N
A
P
Y
R
I
F
N
T
W
L
G
D
P
S
K
N
L
L
L
A
E
V
I
N
I
I
K
R
----
E
D
L
L
S
N
A
A
-
H
A
G
K
V
L
L
T
G
L
L
D
L
Q
A
R
Y
P
Q
F
I
S
R
V
R
G
R
G
T
F
C
S
F
D
T
-
P
D
E
-
S
--
I
-----------
R
-
N
--------
K
L
I
S
I
A
R
N
K
G
V
M
L
G
G
C
--
G
--
D
--
K
S
I
R
F
R
P
T
L
V
F
R
D
H
H
A
H
L
F
L
N
I
F
S
D
I
L
A
D
F
-------
92
HHSearch
57.57
24%
-106
- C2 -
3DOD
2
BIOK_BACSU
A:
[25-443]
-------------------------------------
E
N
P
----
L
I
I
E
S
G
---
T
G
I
K
------------
V
K
D
-
I
-
N
-
G
--
K
E
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
I
A
-
H
S
T
--
L
L
--
G
M
T
N
V
P
A
T
Q
L
A
E
T
----
L
-
I
D
I
---
S
P
K
-
K
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
---
W
K
-
N
I
G
K
P
--------------------
E
K
Q
---
K
F
I
A
M
K
----------------------------
S
Y
K
A
P
I
P
Y
-
V
Y
R
S
E
S
G
D
----
P
D
E
C
R
D
Q
C
-----
L
R
E
L
A
Q
L
L
E
E
---
H
---
H
E
E
I
A
A
-
L
S
I
E
S
M
V
-
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
--
P
D
L
M
----
A
A
-----
G
K
G
I
T
----
G
G
Y
L
P
I
A
V
-
T
-
F
A
T
E
D
I
Y
K
A
F
Y
D
D
YE
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
----
E
N
I
V
E
Q
V
A
-
E
K
S
K
K
L
H
F
L
L
Q
D
L
H
A
-
L
P
-
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
-
V
R
S
-
K
--
E
TKEPYPADRR
I
G
-
Y
--------
K
V
S
L
K
M
R
E
L
G
M
L
T
R
P
L
--
G
-----
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-------
84
HHSearch
55.39
23%
-100
- C2 -
1Z7D
-
OAT_PLAYO
A:
[25-409]
------------------------------------
D
P
I
P
----
V
V
L
K
R
A
---
K
G
V
F
------------
V
Y
D
-
V
-
N
-
D
--
K
R
Y
Y
D
F
L
S
A
Y
S
S
V
N
Q
G
H
C
H
P
N
I
L
N
A
M
I
N
Q
A
K
N
L
T
I
C
-
S
R
-
A
----
F
F
S
V
P
L
G
I
C
E
R
Y
----
L
-
T
N
L
-----
L
-
G
Y
D
K
V
L
M
M
N
T
G
A
E
A
N
E
T
A
Y
K
L
C
R
K
W
---
G
Y
-
E
V
K
K
I
------------------
P
E
N
M
A
---
K
I
V
V
C
K
N
N
------------------------------
Q
F
S
---
K
-
V
P
------------
Y
D
D
-----
L
E
A
L
E
E
E
L
K
D
--------
P
N
V
C
A
-
F
I
V
E
P
-
I
-
Q
G
E
A
G
V
I
V
P
S
D
N
Y
L
Q
G
V
Y
D
I
C
K
K
Y
N
V
L
F
V
A
D
E
V
Q
T
G
L
G
R
T
G
K
L
L
C
V
H
H
--
Y
N
V
K
--
P
D
V
I
----
L
L
-----
G
K
A
L
S
----
G
G
HYP
I
S
A
-
V
-
L
A
N
D
D
I
M
L
V
I
K
-------
P
G
E
H
G
S
T
Y
G
G
N
P
L
A
A
S
I
C
V
E
A
L
N
V
L
I
N
----
E
K
L
C
E
N
A
E
-
K
L
G
G
P
F
L
E
N
L
K
R
E
L
K
D
S
K
-
I
V
R
D
V
R
G
K
G
L
L
C
A
I
E
F
-
K
N
E
L
V
--
N
-----------
V
-
L
--------
D
I
C
L
K
L
K
E
N
G
L
I
T
R
D
V
--
H
--
D
--
K
T
I
R
L
T
P
P
L
C
I
T
K
E
Q
L
D
E
C
T
E
I
I
V
K
T
V
K
F
F
-------
85
HHSearch
54.09
22%
-97
- C2 -
4WYD
13
BIOA_MYCTU
A:
[54-453]
--------------------------------------
S
P
----
V
V
A
V
A
A
---
H
G
A
W
------------
L
T
L
-
I
-
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
M
N
-
H
V
M
F
----
G
G
L
T
H
E
P
A
A
R
L
A
K
L
----
L
-
V
D
I
---
T
P
A
-
G
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
---
W
R
-
G
R
G
L
--------------------
P
G
K
R
---
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
-
V
---
P
R
--------
D
Y
D
P
A
Y
-----
S
A
A
F
E
A
Q
L
A
Q
---
H
---
A
G
E
L
A
A
-
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
--
A
G
V
S
--
P
D
I
M
----
C
V
-----
G
K
A
L
T
----
G
G
Y
L
S
L
A
A
T
L
-
C
T
-
A
D
V
A
H
T
I
S
A
G
--
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
----
Q
D
W
R
T
R
I
T
-
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
-
L
P
-
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
-
D
R
P
-
V
--
D
-----------
L
-
A
--------
V
A
T
P
A
A
L
D
R
G
V
W
L
R
P
F
-----
R
--
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
-------
86
HHSearch
53.55
28%
-89
- C2 -
4UOX
7
PAT_ECOLI
A:
[64-452]
--------------------------------------
G
A
----
V
E
W
Q
A
G
---
S
L
N
T
------------
L
V
D
-
T
-
Q
-
G
--
Q
E
F
I
D
C
L
G
G
F
G
I
F
N
V
G
H
R
N
P
V
V
V
S
A
V
Q
N
Q
L
A
K
Q
P
-
L
--
H
S
Q
---
E
L
L
D
P
L
R
A
M
L
A
K
T
----
L
-
A
A
L
---
T
P
G
-
K
L
K
Y
S
F
F
C
N
S
G
T
E
S
V
E
A
A
L
K
L
A
K
A
Y
---
Q
S
-
P
R
-----------------------
G
K
F
---
T
F
I
A
T
S
G
A
F
H
G
K
S
L
G
A
L
S
A
T
A
K
S
T
F
R
K
P
F
M
P
L
L
----
P
G
F
R
---
H
-
V
P
F
------------
G
N
-----
I
E
A
M
R
T
A
L
N
E
C
K
K
T
---
G
D
D
V
A
A
-
V
I
L
E
P
-
I
-
Q
G
E
G
G
V
I
L
P
P
P
G
Y
L
T
A
V
R
K
L
C
D
E
F
G
A
L
M
I
L
D
E
V
Q
T
G
M
G
R
T
G
K
M
F
A
C
E
H
--
E
N
V
Q
--
P
D
I
L
----
C
L
-----
A
K
A
L
G
----
G
G
V
M
P
I
G
A
-
T
I
A
T
-
E
E
V
F
S
V
L
F
D
-----
N
P
F
L
H
T
T
T
F
G
G
N
P
L
A
C
A
A
A
L
A
T
I
N
V
L
L
E
----
Q
N
L
P
A
Q
A
E
-
Q
K
G
D
M
L
L
D
G
F
R
Q
L
A
R
E
Y
P
D
L
V
Q
E
A
R
G
K
G
M
L
M
A
I
E
F
-
V
D
N
-
E
--
I
-----------
G
-
Y
--------
N
F
A
S
E
M
F
R
Q
R
V
L
V
A
G
T
--
L
NN
A
--
K
T
I
R
I
E
P
P
L
T
L
T
I
E
Q
C
E
L
V
I
K
A
A
R
K
A
L
A
A
M
-------
14
PsiBlast_PDB
53.36
28%
-91
- C2 -
4ZSW
3
GABT_PIG
A:
[31-440]
----------------------------------
E
A
V
H
F
F
----
C
N
Y
E
E
S
---
R
G
N
Y
------------
L
V
D
--
V
D
-
G
--
N
R
M
L
D
L
Y
S
Q
I
S
S
I
P
I
G
Y
S
H
P
A
L
V
K
L
V
Q
-
Q
P
Q
N
V
S
T
F
I
N
R
P
A
---
L
G
I
L
P
P
E
N
F
V
E
K
L
----
R
-
E
S
L
LSV
A
P
K
-
G
M
S
Q
L
I
T
M
A
C
G
S
C
S
N
E
N
A
F
K
T
I
F
M
W
Y
R
S
K
E
-
R
G
E
S
A
F
S
K
E
E
L
E
T
C
M
------
I
N
Q
A
P
G
C
PD
Y
S
I
L
S
F
M
G
A
F
H
G
R
T
M
G
C
L
A
T
T
H
S
K
A
I
H
K
I
D
I
P
S
F
D
W
P
I
A
P
F
P
R
-
L
K
-
Y
P
L
E
E
F
V
--
K
E
N
Q
Q
E
E
A
R
C
L
E
E
V
E
D
L
I
V
K
Y
R
K
---
K
---
K
K
T
V
A
G
-
I
I
V
E
P
-
I
-
Q
S
E
G
G
D
N
H
A
S
D
D
F
F
R
K
L
R
D
I
S
R
K
H
G
C
A
F
L
V
D
E
V
Q
T
G
G
G
S
T
G
K
F
W
A
H
E
H
WG
L
D
D
P
--
A
D
V
M
----
T
F
-----
S
K
K
M
M
----
T
G
----
G
F
-
F
-----
H
K
E
E
F
R
P
N
A
-----
P
Y
R
I
F
N
T
W
L
G
D
P
S
K
N
L
L
L
A
E
V
I
N
I
I
K
R
----
E
D
L
L
S
N
A
A
-
H
A
G
K
V
L
L
T
G
L
L
D
L
Q
A
R
Y
P
Q
F
I
S
R
V
R
G
R
G
T
F
C
S
F
D
T
-
P
D
E
-
S
--
I
-----------
R
-
N
--------
K
L
I
S
I
A
R
N
K
G
V
M
L
G
G
C
--
G
--
D
--
K
S
I
R
F
R
P
T
L
----------------------------
93
HHSearch
52.94
22%
-93
- C2 -
4A6R
2
?
A:
[34-449]
--------------------------------------------
R
V
M
T
R
G
---
E
G
V
Y
------------
L
W
D
-
S
-
E
-
G
--
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
-
F
Y
N
T
F
F
---
K
T
T
H
P
A
V
V
E
L
S
S
L
----
L
-
A
E
V
---
T
P
A
-
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
---
W
D
-
V
Q
G
K
P
--------------------
E
K
K
---
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
--
D
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
-
H
G
K
D
M
T
---
P
D
E
F
G
V
V
A
-----
A
R
W
L
E
E
K
I
L
E
I
--
G
---
A
D
K
V
A
A
-
F
V
G
E
P
-
I
-
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
--
F
G
F
Q
--
P
D
L
F
----
T
A
-----
A
K
G
L
S
----
S
G
Y
L
P
I
G
A
-
V
F
V
G
-
K
R
V
A
E
G
L
I
A
----
G
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
----
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
-
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
-
V
K
N
-
K
--
A
KR
E
L
F
P
DFG
E
I
G
-
T
--------
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--
G
-----
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
-------
31
PsiBlast_CBE
52.89
31%
-87
- C2 -
1SZK
16
GABT_ECOLI
D:
[38-410]
--------------------------------------------------------------------------
V
E
-
G
--
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
L
H
P
K
V
V
-------
A
A
V
E
A
Q
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
EIMN
Q
-
K
V
P
---
G
D
F
-
A
K
K
T
L
L
-
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
A
---
T
K
-
R
--------------------------
S
---
G
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
G
K
V
N
P
Y
S
A
G
M
G
L
M
P
G
H
V
Y
R
A
L
Y
-------
P
C
P
L
--
H
G
I
S
E
D
D
A
-----
I
A
S
I
H
R
I
F
K
N
DA-
A
---
P
E
D
I
A
A
-
I
V
I
E
P
-
V
-
Q
G
S
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
--
M
G
V
A
--
P
D
L
T
----
T
F
-----
A
K
S
I
A
GGFP
L
A
----
G
V
---
T
G
-
R
A
--
E
V
M
D
A
V
----
A
P
G
G
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
----
E
N
L
L
Q
K
A
N
-
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
-
D
V
R
G
L
G
A
M
I
A
I
E
L
-
F
E
D
-
G
--
D
-----------
H
-
N
KPDAKLTA
E
I
V
A
R
A
R
D
K
G
L
I
L
L
S
C
--
G
--
P
YY
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
---------------------
11
PsiBlast_PDB
52.82
28%
-89
- C2 -
1OHY
5
GABT_PIG
A:
[41-450]
----------------------------------
E
A
V
H
F
F
----
C
N
Y
E
E
S
---
R
G
N
Y
------------
L
V
D
--
V
D
-
G
--
N
R
M
L
D
L
Y
S
Q
I
S
S
I
P
I
G
Y
S
H
P
A
L
V
K
L
V
Q
-
Q
P
Q
N
V
S
T
F
I
N
R
P
A
---
L
G
I
L
P
P
E
N
F
V
E
K
L
----
R
-
E
S
L
LSV
A
P
K
-
G
M
S
Q
L
I
T
M
A
C
G
S
C
S
N
E
N
A
F
K
T
I
F
M
W
Y
R
S
K
E
-
R
G
Q
S
A
F
S
K
E
E
L
E
T
C
M
------
I
N
Q
A
P
G
C
PD
Y
S
I
L
S
F
M
G
A
F
H
G
R
T
M
G
C
L
A
T
T
H
S
K
A
I
H
K
I
D
I
P
S
F
D
W
P
I
A
P
F
P
R
-
L
K
-
Y
P
L
E
E
F
V
--
K
E
N
Q
Q
E
E
A
R
C
L
E
E
V
E
D
L
I
V
K
Y
R
K
---
K
---
K
K
T
V
A
G
-
I
I
V
E
P
-
I
-
Q
S
E
G
G
D
N
H
A
S
D
D
F
F
R
K
L
R
D
I
S
R
K
H
G
C
A
F
L
V
D
E
V
Q
T
G
G
G
S
T
G
K
F
W
A
H
E
H
WG
L
D
D
P
--
A
D
V
M
----
T
F
-----
S
K
K
M
M
----
T
G
----
G
F
-
F
-----
H
K
E
E
F
R
P
N
A
-----
P
Y
R
I
F
N
T
W
L
G
D
P
S
K
N
L
L
L
A
E
V
I
N
I
I
K
R
----
E
D
L
L
S
N
A
A
-
H
A
G
K
V
L
L
T
G
L
L
D
L
Q
A
R
Y
P
Q
F
I
S
R
V
R
G
R
G
T
F
C
S
F
D
T
-
P
D
E
-
S
--
I
-----------
R
-
N
--------
K
L
I
S
I
A
R
N
K
G
V
M
L
G
G
C
--
G
--
D
--
K
S
I
R
F
R
P
T
L
----------------------------
57
PsiBlast_CBE
44.47
31%
-84
- C2 -
4JEY
13
ARGD_SALTY
B:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
H
V
G
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
50
PsiBlast_CBE
43.75
31%
-84
- C2 -
4JEW
11
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
58
PsiBlast_CBE
43.63
31%
-84
- C2 -
4JEY
13
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
----
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
59
PsiBlast_CBE
43.61
31%
-84
- C2 -
4JEZ
13
ARGD_SALTY
B:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
56
PsiBlast_CBE
43.52
31%
-84
- C2 -
4JF1
9
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
-------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
53
PsiBlast_CBE
43.37
31%
-83
- C2 -
2PB0
5
ARGD_SALTY
B:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
H
V
G
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
52
PsiBlast_CBE
43.19
31%
-86
- C2 -
2PB2
6
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
----
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
49
PsiBlast_CBE
42.83
31%
-84
- C2 -
4JEW
13
ARGD_SALTY
B:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
H
V
G
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
60
PsiBlast_CBE
42.81
31%
-85
- C2 -
4JEZ
13
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
R
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
54
PsiBlast_CBE
42.74
31%
-85
- C2 -
2PB0
5
ARGD_SALTY
A:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------
55
PsiBlast_CBE
41.87
31%
-82
- C2 -
4JF1
9
ARGD_SALTY
B:
[56-404]
-----------------------------------------------------------------------------
G
--
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
----
A
E
R
V
L
-------------
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
---
A
C
V
R
H
S
---------------------
P
F
K
T
---
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
-
G
G
Q
P
K
Y
S
D
G
F
G
P
K
P
A
D
I
I
H
V
P
F
-------------------
N
D
-----
L
H
A
V
K
A
V
M
D
----------
D
H
T
C
A
V
V
V
E
P
-
I
-
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
--
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
-----
G
G
G
F
P
----
V
S
----
A
M
-
L
-
T
----
T
Q
E
I
A
-
S
A
--
F
H
V
G
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
-
Q
F
V
Q
H
L
Q
A
-
I
D
E
Q
F
D
I
F
S
----
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
-
K
--
G
-----------
R
A
R
--------
D
F
L
Y
A
G
A
E
A
G
V
M
V
L
N
A
--
G
--
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
---------------------