@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5472: (2016-03-08 )
MRMRFSGISGCLSAAVLALGVGGAPVVQADALGDSLEQAHIRKATFAAPAWEGYTNADGSGLYWDLLKQVYAPYGLDVKFINMPWNRANKLMTAGSMVDGVPGEIPGVEGKLYAQLPIDIEYHGVMHAAKTPFSGRASLTGKRVGWRHSYNLIPAEQRDFTLVECVRPERCTEQVQNGELDFFLDEPDELEKQRSEAHLPADAYPIAQLPPGKESFMTFADSASGRLLREVYDARVRQMAASGELRALYQRWNSEVPGAVQALSAQ
Atome Classification :
(20 SA)
---.........10........20........-30........40.......-------.-50..-----..-..-.-----.60........70----...-------.--....80.-.------------.-.....90......---.--.-.100-........---110----......-.120----...-------.....130-.--...-.---...140.......---..150...--...-------.--160........170.....--..-180....-------...190.-......-200.------..--.----.--.-----.-------------------210---.-...---.----...220..---------.....230.......240...--....250-......-.260....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
R
M
RFS
G
I
S
G
C
L
S
A
A
V
L
A
LGVGGA
P
V
V
Q
A
-
D
ALG
D
S
L
E
Q
A
H
I
R
K
ATFAA-------P-AWEG-----YT-NA-D-----GS
G
L
Y
W
D
L
L
K
Q
V
Y----APY-------G--
L
D
V
K
F
I
N-M------------P-WNRANK-
L
M
TAGS---M--V-DG-V-PGEIPGVE---
G
K
L
----
Y
A
QL
P
I
-
D
I
-
E
----YH
G
-------
V
M
HAAKT--P--FSG-R---ASLT--GKRVGWR---HSYNLIPA--EQR-------
D
--
F
-
T
L
V
E
CV
R
P
E
R
C
T
E
Q
V
QN--G
E
-
L
D
F
FLDE-------
P
D
E
L
E
K
Q
-
R
S
EAHL-PADA------YP--I----A--Q-----L-------------------PP----G-
K
E
S
---
F
----
M
T
FADSAS---------
G
R
L
L
R
E
V
Y
D
A
R
V
R
Q
M
AAS
G
E
L
--
R
A
L
Y
Q
R
W-NSEVP
G
-
A
V
Q
ALSAQ-------
29
HHSearch
83.58
16%
-60
- C8 -
2Y7I
7
?
A:
[3-228]
------------------------------------------
V
S
A
R
T
L
H
F
G
T
S
------
A
-
T
Y
A
P
-----
Y
E
-
F
V
-
D
ADNK-
I
V
G
F
D
I
D
V
A
N
A
V
C
----
K
E
M
-------
Q
--
A
E
C
S
F
T
N
-
Q
------------
S
-
F
D
S
L
I
P
-
S
L
R
F
K
K
FD-
A
V
I
A
-
G
M
-
D
-
M
T
P
--
K
R
E
Q
--
Q
V
S
----
F
S
Q
-
P
Y
-
Y
E
-
G
----
L
S
A
-------
V
V
V
T
R
K
G
--
A
--
Y
H
T
-
F
---
A
D
L
K
--
G
K
K
V
G
L
E
---
N
G
T
T
H
Q
R
Y
--
L
Q
D
KQQ----
A
--
I
-
T
P
V
A
Y
D
S
Y
L
N
A
F
T
D
L
K
N
--
N
R
-
L
E
G
V
F
G
D
-------
V
A
A
I
G
K
W
-
L
K
N
N
P
--
D
Y
A
I
------
M
D
E
R
A
S
D--
P
--
D
-----
Y
-------------------
Y
G
------
K
G
L
---
G
----
I
A
V
R
K
D
N
-----------
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
--
A
Q
M
Q
E
K
W
-
F
T
--------------------
31
HHSearch
82.58
14%
-57
* C8 *
3VV5
1
?
A:
[31-257]
----------------------------------------
E
I
K
R
S
G
E
I
R
I
G
T
E
------
G
-
A
F
P
P
-----
F
N
-
Y
F
-
D
ERN
Q
-
L
T
G
F
E
V
D
L
G
N
A
I
A
----
E
R
L
-------
G
--
L
K
P
R
W
I
A
-
Q
------------
S
-
F
D
T
L
L
I
-
Q
L
N
Q
G
R
FDF
V
--
I
A
S
H
-
G
-
I
T
E
--
E
R
A
R
--
A
V
D
----
F
T
N
-
P
H
-
Y
C
-
T
----
G
G
V
-------
I
V
S
R
K
G
G
-----
P
R
T
-
A
---
K
D
L
Q
--
G
K
V
V
G
V
Q
---
V
G
T
T
Y
M
E
A
--
A
Q
K
IP-----
G
--
I
K
E
V
R
T
Y
Q
R
D
P
D
A
L
Q
D
L
L
A
--
G
R
-
I
D
T
W
I
T
D
-------
R
F
V
A
K
E
A
-
I
K
E
R
K
--
L
E
N
T
------
L
Q
--
V
G
---
E
--
L
-----
V
-------------------
F
Q
------
E
R
V
---
A
----
M
A
V
A
K
G
N
-----------
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
--
A
R
I
S
Q
K
W
-
F
G
E
D
V
-----------------
36
Fugue
79.97
15%
-59
- C8 -
1HSL
6
HISJ_ECOLI
A:
[1-238]
--------------
A
I
P
Q
K
I
R
I
G
T
D
P
----------------------
T
Y
A
P
-------
F
-
E
S
K
N
------
A
-
Q
G
-
E
-----
L
V
G
F
D
I
D
L
A
K
E
L
C
----
K
R
I
-------
N
--
T
Q
C
T
F
V
E
-
N
------------
P
-
L
D
A
L
I
P
-
S
L
K
A
K
K
---
I
----
D
A
-
I
-
M
S
S
L
S
I
T
E
---
K
R
Q
Q
E
I
A
F
T
D
K
L
Y
-
A
A
-
D
----
S
R
L
-------
V
V
A
K
N
S
---
D
--
I
Q
P
T
V
---
A
S
L
K
--
G
K
R
V
G
V
L
Q
GT
T
Q
E
T
F
G
N
E
HW
A
P
K
-------
G
--
I
-
E
I
V
S
Y
Q
G
Q
D
N
I
Y
S
D
L
T
A
--
G
R
-
I
D
A
A
F
Q
D
-------
E
V
A
A
S
E
G
-
F
L
K
Q
P
V
-
G
K
D
Y
------
K
F
--
G
----
G
--
P
-----
A
-------------------
V
K
----
D
-
E
K
L
FGV
G
----
T
G
M
G
L
R
K
E
---------
D
N
E
L
R
E
A
L
N
K
A
F
A
E
M
R
A
D
G
T
Y
--
E
K
L
A
K
K
Y
F
D
F
D
V
Y
G
-
G
--------------
24
HHSearch
76.77
15%
-56
- C8 -
2PVU
3
?
A:
[38-265]
-----------------------------------------
G
A
T
K
K
K
V
V
V
G
T
D------
A
-
A
F
A
P
-----
F
E
-
Y
M
-
Q
KGK--
I
V
G
F
D
V
D
L
L
D
A
V
M
----
K
A
A
-------
G
--
L
D
Y
E
L
K
N
-
I
------------
G
-
W
D
P
L
F
A
-
S
L
Q
S
K
E
VD-
M
G
I
S
-
G
I
-
T
-
I
T
D
--
E
R
K
Q
--
S
Y
D
----
F
S
D
-
P
Y
-
F
E
-
A
----
T
Q
V
-------
I
L
V
K
Q
G
S
--
P
--
V
K
N
-
A
---
L
D
L
K
--
G
K
T
I
G
V
Q
---
N
A
T
T
G
Q
E
A
--
A
E
K
L
FGK---
G
--
P
-
H
I
K
K
F
E
T
T
V
V
A
I
M
E
L
L
N
--
G
G
-
V
D
A
V
I
T
D
-------
N
A
V
A
N
E
Y
-
V
K
N
N
P
---
N
K
K
------
L
Q
--
V
I
E
D
-
P
K-
N
-----
F
-------------------
A
S
------
E
Y
Y
---
G
----
M
I
F
P
K
N
------------
S
E
L
K
A
K
V
D
E
A
L
K
N
V
I
N
S
G
K
Y
--
T
E
I
Y
K
K
W
-
F
G
K
E
P
-----------------
35
HHSearch
74.60
17%
-64
- C8 -
3MPK
4
A:
[26-251]
---------------------------------------
Q
W
M
A
D
H
P
V
V
K
V
A
V
L
------
N
-
L
F
A
P
-----
F
T
-
L
F
-
R
TDE
Q
-
F
G
G
I
S
A
A
V
L
Q
L
L
Q
----
L
R
T
-------
G
--
L
D
F
E
I
I
G
-
V
------------
D
T
V
E
E
L
I
A
-
K
L
R
S
G
E
ADM
A
--
G
-
A
L
-
F
-
V
N
S
--
A
R
E
S--
F
L
S
----
F
S
R
-
P
Y
-
V
R
-
N
----
G
M
V
-------
I
V
T
R
Q
D
P
--
D
A-
P
V
D
-
A
---
D
H
L
D
--
G
R
T
V
A
L
V
---
R
N
S
A
A
I
P
L
--
L
Q
R
R
Y
P----
Q
--
A
-
K
V
V
T
A
D
N
P
S
E
A
M
L
M
V
A
N
--
G
Q
-
A
D
A
V
V
Q
T
-------
Q
I
S
A
S
Y
Y
-
V
N
R
Y
F
---
A
G
K
------
L
R
--
I
A---
S
AL
D
-----
L
-------------------
P
P
------
A
E
I
---
A
----
L
A
T
T
R
G
Q
-----------
T
E
L
M
S
I
L
N
K
A
L
Y
S
I
S
N
-
D
E
L
--
A
S
I
I
S
R
W
-
R
---------------------
23
HHSearch
73.19
14%
-45
- C8 -
2Q88
3
?
A:
[6-244]
--------------------------------------
L
E
E
L
K
E
Q
G
F
A
R
I
A
I
-------
A
-
N
E
P
P
-----
F
T
-
A
V
-
G
ADG
K
-
V
S
G
A
A
P
D
V
A
R
E
I
F
----
K
R
L
-------
G
--
V
A
D
V
V
A
S
I
S
------------
E
-
Y
G
A
M
I
P
-
G
L
Q
A
G
R
HD-
A
IT
A
-
G
L
-
F
-
M
K
P
--
E
R
C
A
--
A
V
A
----
Y
S
Q
-
P
I
-
L
C
-
D
----
A
E
A
-------
F
A
L
K
K
G
N
--
P
LG
L
K
S
-
Y
K
D
I
A
D
N
P
--
D
A
K
I
G
A
P
---
G
G
G
T
E
E
K
L
--
A
L
E
A
GVP---
R
--
D
-
R
V
I
V
V
P
D
G
Q
S
G
L
K
M
L
Q
D
--
G
R
-
I
D
V
Y
S
L
P
-------
V
L
S
I
N
D
L
-
V
S
K
A
N
---
D
P
N
------
V
E
--
V
L
---
A
--
P
-----
V
-------------------
E
G
A
---
P
V
Y
C
D
---
G
----
A
A
F
R
K
G
D
-----------
E
A
L
R
D
A
F
D
V
E
L
A
K
L
K
E
S
G
E
F
--
A
K
I
I
E
P
Y
-
G
F
S
A
K
A
----------------
28
HHSearch
72.94
13%
-44
- C8 -
2VHA
2
?
A:
[10-252]
--------------------------------------
L
D
K
I
A
K
N
G
V
I
V
V
G
H
R
------
E
-
S
S
V
P
-----
F
S
-
Y
Y
-
D
NQQK-
V
V
G
Y
S
Q
D
Y
S
N
A
I
V
----
E
A
V
K
K
K
L
NKP
D
--
L
Q
V
K
L
I
P
-
I
------------
T
-
S
Q
N
R
I
P
-
L
L
Q
N
G
T
FD
F
E
--
C
G
S
T
-
T
-
N
N
V
--
E
R
Q
K
--
Q
A
A
----
F
S
D
-
T
I
-
F
V
-
V
----
G
T
R
-------
L
L
T
K
K
G
G
--
D
--
I
K
D
-
F
---
A
D
L
K
--
G
K
A
V
V
V
T
---
S
G
T
T
S
E
V
L
--
L
N
K
L
N
E
E
Q
KM
N
--
M
-
R
I
I
S
A
K
D
H
G
D
S
F
R
T
L
E
S
--
G
R
-
A
V
A
F
M
M
D
-------
D
A
L
L
A
G
E
-
R
A
K
A
K
--
K
P
D
N
------
W
D
--
I
V
G
--
K
--
P
-----
Q
-------------------
S
Q
------
E
A
Y
---
G
----
C
M
L
R
K
D
D
-----------
P
Q
F
K
K
L
M
D
D
T
I
A
Q
V
Q
T
S
G
E
A
--
E
K
W
F
D
K
W
-
F
K
N
P
I
P
----------------
32
HHSearch
71.50
14%
-63
- C8 -
2PYY
1
?
A:
[4-223]
----------------------------------------------
P
L
L
V
A
T
-------
R
-
V
I
P
P
-----
F
V
-
L
S
-
N
-----
L
S
G
F
S
I
D
L
W
R
S
I
A
----
T
Q
I
-------
G
--
I
E
S
K
L
I
E
-
Y
------------
S
S
V
P
E
L
I
S
-
A
I
K
D
N
K
VN-
L
G
I
A
-
A
I
-
S
-
I
T
A
--
E
R
E
Q
--
N
F
D
----
F
S
L
-
P
I
-
F
A
-
S
----
G
L
Q
-------
I
M
V
R
N
--G-
D
--
I
R
S
-
I
---
D
D
L
P
--
G
K
V
V
A
T
T
---
A
G
S
T
A
A
T
Y
--
L
R
E
H
------
H
--
I
-
S
V
L
E
V
P
K
I
E
E
A
Y
K
A
L
Q
T
--
K
K
-
A
D
A
V
V
F
D
-------
A
P
V
L
L
F
Y
-
A
A
N
E
G
---
K
G
K
------
V
E
--
I
V
G
--
S
--
I
-----
L
-------------------
R
E
------
E
S
Y
---
G
----
I
I
L
P
N
N
------------
S
P
Y
R
K
P
I
N
Q
A
L
L
N
L
K
E
N
G
T
Y
--
Q
S
L
Y
D
K
W
-
F
D
P
-------------------
33
HHSearch
71.29
15%
-75
- C8 -
3TQL
2
?
A:
[2-227]
---------------------------------------------
D
T
I
K
F
A
T
E------
A
-
T
Y
P
P
-----
Y
V
-
Y
M
-
G
G
Q
---
V
E
G
F
G
A
D
I
V
K
A
V
C
----
K
Q
M
-------
Q
--
A
V
C
T
I
S
N
-
Q
------------
P
-
W
D
S
L
I
P
-
S
L
K
L
G
K
FD
A
L
F
-
G
-
G
M
-
N
-
I
T
T
--
A
R
Q
K
--
E
V
D
----
F
T
D
-
P
Y
-
Y
T
-
N
----
S
V
S
-------
F
I
A
D
K
N
T
--
P
L-
T
L
S
-
K
---
Q
G
L
K
--
G
K
I
I
G
V
Q
---
G
G
T
T
F
D
S
Y
--
L
Q
D
S
FGN---
S
--
I
-
T
I
Q
R
Y
P
S
E
E
D
A
L
M
D
L
T
S
--
G
R
-
V
D
A
V
V
G
D
-------
T
P
L
I
K
Q
W
-
L
K
Q
N
G
---
R
R
E
------
Y
V
--
L
I
G
--
K
--
P
-----
V
-------------------
N
D
PNYF
G
-
K
G
V
---
G
----
I
A
V
K
K
G
N
-----------
Q
A
L
L
L
K
L
N
K
A
L
A
A
I
K
A
N
G
V
Y
--
A
A
I
V
Q
K
Y
-
F
---------------------
17
HHSearch
71.12
14%
-54
- C8 -
3H7M
1
?
A:
[7-232]
-----------------------------------------
R
D
R
H
R
T
I
V
V
G
G
D
------
R
-
D
Y
P
P
-----
Y
E
-
F
I
-
D
QNGK-
P
A
G
Y
N
V
E
L
T
R
A
I
A
----
E
V
M
-------
G
--
M
T
V
E
F
R
L
-
G
------------
A
-
W
S
E
M
F
S
-
A
L
K
S
G
R
VDV
L
--
Q
-
G
I
-
S
-
W
S
E
--
K
R
A
R
--
Q
I
D
----
F
T
P
-
P
H
-
T
I
-
V
----
Y
H
A
-------
I
F
A
R
R
D
S
--
P
P-
A
A
G
-
L
---
E
D
L
R
--
G
R
K
V
A
L
H
---
R
D
G
I
M
H
E
Y
--
L
A
E
R
GY----
G
--
K
-
D
L
V
L
T
P
T
P
A
D
A
L
R
L
L
A
A
--
G
G
-
C
D
Y
A
V
V
A
-------
M
V
P
G
M
Y
I
-
I
R
E
N
R
---
L
T
N
------
L
V
--
P
VA--
R
--
S
-----
I
-------------------
A
A
------
Q
R
Y
---
G
----
Y
A
V
R
Q
G
D
-----------
A
E
L
L
A
R
F
S
E
G
L
A
I
L
R
K
T
G
Q
Y
--
E
A
I
R
A
K
W
-
L
G
V
L
------------------
18
HHSearch
70.81
14%
-49
- C8 -
2V25
3
PEB1A_CAMJE
A:
[29-258]
------------------------------------
G
K
L
E
S
I
K
S
K
G
Q
L
I
V
G
V
K
------
N
-
D
V
P
H
-----
Y
A
-
L
L
-
D
QATGE
I
K
G
F
E
V
D
V
A
K
L
L
A
----
K
S
I
L------
G
DD
K
K
I
K
L
V
A
-
V
------------
N
-
A
K
T
R
G
P
-
L
L
D
N
G
S
VDA
V
--
I
A
T
F
-
T
-
I
T
P
--
E
R
K
R
--
I
Y
N
----
F
S
E
-
P
Y
-
Y
Q
-
D
----
A
I
G
-------
L
L
V
L
K
E
K
--
K
--
Y
K
S
-
L
---
A
D
M
K
--
G
A
N
I
G
V
A
---
Q
A
A
T
T
K
K
A
--
I
G
E
A
A
K
K
I
--
G
I
D
V
-
K
F
S
E
F
P
D
Y
P
S
I
K
A
A
L
D
A
--
K
R
-
V
D
A
F
S
V
D
-------
K
S
I
L
L
G
Y
-
V
D
D
K
S
-----
E
------
I
L
--
P
----
D
--
S
-----
F
-------------------
E
P
------
Q
S
Y
---
G
----
I
V
T
K
K
D
D
-----------
P
A
F
A
K
Y
V
D
D
F
V
K
E
H
K
N
--
E
I
--
D
A
L
A
K
K
W
-
G
---------------------
16
HHSearch
70.02
13%
-49
- C8 -
2YJP
10
?
A:
[49-282]
---------------------------------------
A
A
I
K
E
K
G
V
I
R
I
G
V
F
------
G
-
D
K
P
P
-----
F
G
-
Y
V
-
D
ANG
K
-
N
Q
G
F
D
V
E
I
A
K
D
L
A
----
K
D
L
LGS----
P
--
D
K
V
E
F
V
L
-
T
------------
E
-
A
A
N
R
V
E
-
Y
V
R
S
G
K
VDL
I
--
L
A
N
F
-
T
-
Q
T
P
--
E
R
A
E
--
A
V
D
----
F
A
D
-
P
Y
-
M
K
-
V
----
A
L
G
-------
V
V
S
P
K
N
K
--
P
--
I
T
D
-
M
---
A
Q
L
K
--
D
Q
T
L
L
V
N
---
K
G
T
T
A
D
A
F
--
F
T
K
SHP----
E
--
V
-
K
L
L
K
F
D
Q
N
T
E
T
F
D
A
L
K
D
--
G
R
-
G
V
A
L
A
H
D
-------
N
A
L
L
W
A
W
-
A
K
E
N
P
--
N
-
F
E
------
V
A
--
I
----
G
--
N
-----
L
G
------------------
P
A
------
E
F
I
---
A
----
P
A
V
Q
K
G
N
-----------
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
--
K
A
A
Y
E
K
T
-
L
L
P
V
Y
G
-
E
K
-------------
27
HHSearch
68.45
10%
-55
- C8 -
3KBR
10
PHEC_PSEAE
A:
[8-236]
--------------------------------------
L
D
R
I
L
E
S
G
V
L
R
V
A
T
T------
G
-
D
Y
K
P
-----
F
S
-
Y
R
-
T
EEG
G
-
Y
A
G
F
D
V
D
M
A
Q
R
L
A
----
E
S
L
-------
G
--
A
K
L
V
V
V
P
-
T
------------
S
-
W
P
N
L
M
R
-
D
F
A
D
D
R
FD
I
A
M
-
S
-
G
I
-
S
-
I
N
L
--
E
R
Q
R
--
Q
A
Y
----
F
S
I
-
P
Y
-
L
R
-
D
----
G
K
T
-------
P
I
T
L
C
S
E
EA
R
--
F
Q
T
-
L
---
E
Q
I
D
QP
G
V
T
A
I
V
N
---
P
G
G
T
N
E
K
F
--
A
R
A
N
LK----
K
--
A
-
R
I
L
V
H
P
D
N
V
T
I
F
Q
Q
I
V
D
--
G
K
-
A
D
L
M
M
T
D
-------
A
I
E
A
R
L
Q
-
S
R
L
H
P
--
E
L
C
A
------
V
H
--
P
----
Q
--
P
-----
F
-------------------
D
F
------
A
E
K
---
A
----
Y
L
L
P
R
D
------------
E
A
F
K
R
Y
V
D
Q
W
L
H
I
A
E
Q
S
G
L
L
--
R
Q
R
M
E
H
W
-
L
---------------------
45
Fugue
68.22
18%
-34
- C5 -
4CIJ
-
?
A:
[3-269]
-------
M
S
G
L
K
P
C
V
D
W
L
Q
V
T
F
K
T
G
Q
D
S
V
K
K
C
V
E
K
L
E
K
V
F
E
I
L
G
L
N
E
A
E
F
L
P
-------
L
-
K
N
G
K
-----
Y
G
-
Y
K
-
Q
-----
G
V
A
F
Q
G
N
P
V
L
A
V
Y
Y
DGA
D
D
M
-------
G
--
I
H
V
E
M
-
T
-
G
------------
Q
-
G
C
R
L
F
E
-
L
H
T
S
I
N
---
W
--
Y
-
E
L
-
F
-
Y
R
L
V
Y
E
Y
E
---
V
N
I
----
T
-
R
L
D
V
-
A
V
-
D
D
FKG
Y
F
K
-------
I
N
T
L
V
K
K
--
L
--
K
D
D
-
E
-----
V
T
--
S
R
F
K
K
A
R
---
H
I
E
N
I
V
I
E
--
G
G
E
-------
T
--
I
-
G
H
T
L
Y
F
G
A
P
S
S
D
I
Q
V
R
F
--
Y
E
-
K
N
V
Q
M
G
M
-------
D
I
D
V
W
-
N
-
R
T
E
I
Q
L
R
D
D
R
A
------
H
V
--
V
----
A
--
Q
-----
I
-------------------
I
A
----
D
-
D
V
---------
L
P
L
G
E
I
V
A
---------
G
-
L
L
R
N
Y
I
Q
F
R
T
R
K
A
T
D
K
N
K
K
--
R
W
P
L
A
R
F
-
W
L
N
F
L
G
-
D
V
Q
P
L
R
I
A
KQM----
20
HHSearch
67.41
12%
-52
- C8 -
2YLN
10
?
A:
[52-280]
----------------------------------------
R
I
N
N
K
G
T
V
T
V
G
T
E------
G
-
T
Y
A
P
-----
F
T
-
Y
H
-
D
KDG
K
-
L
T
G
Y
D
V
E
V
T
R
A
V
A
----
E
K
L
-------
G
--
V
K
V
E
F
K
E
-
T
------------
Q
-
W
D
S
M
M
A
-
G
L
K
A
G
R
FDV
V
--
A
-
N
Q
V
G
L
T
S
P
--
E
R
Q
A
--
T
F
D
----
K
S
E
-
P
Y
-
S
W
-
S
----
G
A
V
-------
L
V
A
H
N
D
S
--
N
--
I
K
S
-
I
---
A
D
I
K
--
G
V
K
T
A
Q
S
---
L
T
S
N
Y
G
E
K
--
A
K
A
A
------
G
--
A
-
Q
L
V
P
V
D
G
L
A
Q
S
L
T
L
I
E
Q
--
K
R
-
A
D
A
T
L
N
D
-------
E
L
A
V
L
D
Y
-
L
K
K
N
P
---
N
A
G
------
V
K
--
I
VWSA
P
--
A
-----
D
-------------------
E
K
------
V
G
S
---
G
----
L
I
V
N
K
G
N
-----------
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
--
K
K
L
G
E
Q
F
-
F
G
K
D
I
-----------------
26
HHSearch
64.78
11%
-56
- C8 -
1LST
1
ARGT_SALTY
A:
[2-234]
-------------------------------------------
L
P
Q
T
V
R
I
G
T
D
------
T
-
T
Y
A
P
-----
F
S
-
S
K
-
D
AKGE-
F
I
G
F
D
I
D
L
G
N
E
M
C
----
K
R
M
-------
Q
--
V
K
C
T
W
V
A
-
S
------------
D
-
F
D
A
L
I
P
-
S
L
K
A
K
K
IDA
I
I-
S
-
S
L
-
S
-
I
T
D
--
K
R
Q
Q
--
E
I
A
----
F
S
D
-
K
L
-
Y
A
-
A
----
D
S
R
-------
L
I
A
A
K
G
S
--
P
I-
Q
P
T
-
L
---
E
S
L
K
--
G
K
H
V
G
V
L
---
Q
G
S
T
Q
E
A
Y
--
A
N
D
N
WRTK--
G
--
V
-
D
V
V
A
Y
A
N
Q
D
L
I
Y
S
D
L
T
A
--
G
R
-
L
D
A
A
L
Q
D
-------
E
V
A
A
S
E
G
F
L
K
Q
P
A
---
G
K
E
------
Y
A
--
F
AG--
P
--
S
VKDKK
Y
-------------------
F
G
------
D
G
T
---
G
----
V
G
L
R
K
D
D
-----------
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
--
D
K
M
A
K
K
Y
-
F
D
F
N
------------------
41
Fugue
63.77
13%
-45
* C5 *
1TRK
2
TKT1_YEAST
A:
[3-337]
------
Q
F
T
D
I
D
K
L
A
V
S
T
I
R
I
L
A
V
D
T
V
S
K
A
N
S
-
G
H
P
G
A
P
L
G
M
A
P
A
A
H
V
L
W
S
Q
M
R
M
N
PTN
P
-
D
W
I
N
R
D
R
F
V
L
S
-
N
G
-
H
-----
A
V
A
L
L
Y
S
M
L
H
L
------
T
G
Y
-------
D
--
L
S
I
E
D
L
K
-
Q
FRQLGSRTPGHP
E
-
F
E
L
P
G
V
-
E
V
T
T
G
P
---
L
--
G
-
Q
G
-
I
-
S
N
A
V
G
M
A
M
---
A
Q
A
----
N
L
A
A
T
Y
-
N
K
-
P
----
G
F
T
L
S
D
N
Y
T
Y
V
F
L
G
D
G
C
--
L
--
Q
E
G
-
I
---
S
S
E
A
--
S
S
L
A
G
H
L
---
K
L
G
N
L
I
A
I
--
Y
D
D
-------
N
--
K
-
I
T
I
D
G
A
T
S
I
S
F
D
E
D
V
A
K
R
Y
E
A
-
Y
G
W
E
V
L
Y
V
ENGNED
L
A
G
I
A
K
A
-
I
A
Q
A
K
L
-
S
K
D
K
------
P
T
--
L
----
I
--
K
-----
M
T
T
T
I
GYGSLHAGSHSVHGA
P
L
----
K
-
A
D
D
---
V
----
K
Q
L
K
S
K
F
G
FNPDKSFVV
P
Q
E
V
Y
D
H
Y
Q
K
T
I
L
K
P
G
V
E
A
N
N
K
W
N
K
L
F
S
E
Y
-
Q
K
K
F
P
E
-
L
G
A
E
L
A
R
R
L
S
GQ---
22
HHSearch
63.06
13%
-54
- C8 -
1WDN
1
GLNH_ECOLI
A:
[4-224]
----------------------------------------------
K
L
V
V
A
T
-------
D
T
A
F
V
P
-----
F
E
-
F
K
-
Q
GDL--
Y
V
G
F
D
V
D
L
W
A
A
I
A
----
K
E
L
-------
K
--
L
D
Y
E
L
K
P
-
M
------------
D
-
F
S
G
I
I
P
-
A
L
Q
T
K
N
VD-
L
AL
A
-
G
I
-
T
-
I
T
D
--
E
R
K
K--
A
I
D
----
F
S
D
-
G
Y
-
Y
K
-
S
----
G
L
L
-------
V
M
V
K
A
N
N
--
N
D-
V
K
S
-
V
---
K
D
L
D
--
G
K
V
V
A
V
K
---
S
G
T
G
S
V
D
Y
--
A
K
A
N
IK----
T
--
K
-
D
L
R
Q
F
P
N
I
D
N
A
Y
M
E
L
G
T
--
N
R
-
A
D
A
V
L
H
D
-------
T
P
N
I
L
Y
F
-
I
K
T
A
G
---
N
G
Q
------
F
K
--
A
V
G
--
D
--
S
-----
L
-------------------
E
A
------
Q
Q
Y
---
G
----
I
A
F
P
K
G
S
-----------
D
E
L
R
D
K
V
N
G
A
L
K
T
L
R
E
N
G
T
Y
--
N
E
I
Y
K
K
W
-
F
G
T
E
------------------
25
HHSearch
62.25
9%
-66
- C8 -
1II5
1
?
A:
[2-226]
-------------------------------------------
S
A
M
A
L
K
V
G
V
-------
V
-
G
N
P
P
-----
F
V
-
F
Y
-
G
A----
F
T
G
I
S
L
D
V
W
R
A
V
A
----
E
S
Q
-------
K
--
W
N
S
E
Y
V
R
-
Q
------------
N
S
I
S
A
G
I
T
-
A
V
A
E
G
E
LD
I
L
--
I
G
P
I
-
S
-
V
T
P
--
E
R
A
A
IE
G
I
T
----
F
T
Q
-
P
Y
-
F
S
-
S
----
G
I
G
-------
L
L
I
P
G
T
A
--
T
PL
F
R
S
-
V
---
G
D
L
K
--
N
K
E
V
A
V
V
---
R
D
T
T
A
V
D
W
--
A
N
F
Y
------
Q
--
A
-
D
V
R
E
T
N
N
L
T
A
A
I
T
L
L
Q
K
--
K
Q
-
V
E
A
V
M
F
D
-------
R
P
A
L
I
Y
Y
-
T
R
Q
N
P
---
N
L
N
------
L
E
--
V
T
E--
I
--
R
-----
V
-------------------
S
L
------
E
P
Y
---
G
----
F
V
L
K
E
N
------------
S
P
L
Q
K
T
I
N
V
E
M
L
N
L
L
Y
S
R
V
I
--
A
E
F
T
E
R
W
-
L
G
--------------------
43
Fugue
61.04
19%
-56
- C4 -
4L4W
-
?
A:
[1-267]
GHM
G
P
N
A
V
E
L
T
T
D
Q
A
W
C
L
A
D
V
L
G
A
G
S
Y
P
W
V
L
A
---
I
T
P
P
Y
S
D
H
S
Q
R
S
A
F
L
A
A
-------
Q
-
S
A
E
L
-----
T
R
M
G
V
V
N
-----
S
A
G
A
V
D
P
R
V
A
Q
W
I
----
T
T
V
-------
C
--
R
A
T
Q
W
L
D
-
L
------------
R
-
F
V
L
L
R
G
M
V
A
R
R
S
--------------
E
E
T
V
V
A
L
R
---
N
A
Q
----
L
V
T
F
T
A
M
D
I
G
H
----
Q
H
A
-------
L
V
P
V
L
T
A
--
G
--
L
S
G
-
R
---
K
---------------------
P
A
--
R
F
D
-------
D
--
F
-
A
L
P
-
A
A
A
G
A
R
A
D
E
Q
I
R
N
--
G
A
P
L
A
E
V
L
E
F
-------
L
G
V
P
P
S
A
-
R
P
L
V
E
S
-
V
F
D
G
R
R
T
Y
V
E
I
V
--
A
----
G
--
E
-----
H
-------------------
R
D
----
G
-
H
R
V
---
T
T
E
V
G
V
S
I
I
D
T
P
H
---------
G
R
I
L
V
H
P
T
K
A
F
------
D
G
E
W
--
I
S
T
F
T
P
G
-
S
A
D
A
I
A
M
A
V
E
R
L
T
A
S
LPSGSWF