@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VNC2: (2017-11-13 )
MATPFWYNTALHLLKPFYRWRIKRRAESLELYQQECLERFGPFEAPKNVKAIWFHAVSVGETNAAQPLIEYYLKLGQPVLVTNTTKTGQARAKSLFLKEPYLDLFQAVYLPVDQKPLLKKFFELYQPKLLALVETELWPNLIDQAKLQHVPCLLLNARLSEKSAKGYGKVSGLTAGMLKQLDWVLAQDSATRQRYVELGLDEHKSQVVGNIKFDIHAPEAFIKQAAQLRQQWYLENRQVVTIASTHAPEEQQILEAFAPYLNSDRELVCIVVPRHPERFDEVFEICQNLNLITHRRSMGQSIHASTQVYLADSMGELWLWYALSQVCFVGGSLNEPGGGHNILEPMVLNVPTVVGPRYFNFQTIVDEFIDENAVLIAQDAQQVVDIWLACLAEPEATEQLVAQAHKVLQRNQGSLQKHIGVINRYLAEKS
Atome Classification :
(20 SA)
------------------------....------------..-...10........20........30-------.........40.....-...50.........60------........70....--....80........90..--......100....-..---.110-----------.------------..----------------....-----.120.-.--.-....130.......140-----.-.---....-...150.......160...-..--------------.--.170.......180.......190--......-----.200....-....210.......220..-----.....230....---.-...240....-.-.-.--250..-.......260------.--......270....----..-------------.280..-....-.-290---........300.......310--.--.--.....320--------...-.....-----330.------......340.......350......-.360.......370.---....--..380.......390.......400.......410-...---......420.......430----
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MATP------------
F
W
-
Y
N
T
A
L
H
L
L
K
P
F
Y
R
W
R
I
K
R
R
A
E
S
L
E
--------
L
Y
Q
Q
E
C
L
E
RFGPFEAP-KN
V
K
-
A
I
W
F
H
A
V
SVGE------TNAA
Q
P
L
I
E
Y
Y
L
KL--GQ
P
V
L
V
T
NTTKTG
Q
A
R
A
K
--
S
LFLK
E
P
Y
L
D
L
F
Q
-
A
V
---YLP------------V------------DQ----------------
K
P
L
L
-----
K
K
F
F
E
-L--Y-
Q
P
K
L
L
A
L
V
E
T
E
L
W
P
N
-------
L
-
I
---
D
Q
A
K
-
L
Q
HV
P
C
L
L
LNARLSEKSAK-GY--------------G--
K
V
S
G
L
T
A
G
M
L
K
Q
L
D
W
V
LAQDS
A
T
R
--
Q
R
Y
V
E
L-----G
L
-
D
E
H
K
S
-
Q
V
V
G
N
I
K
F
D
IHA
P
E
A
F
I
K
Q
-----
A
A
Q
L
R
Q
Q
-
W
YLE---N-
R
Q
V
V
T
I
ASTH-A-P-
E
--
E
--
Q
Q
-
I
L
E
A
F
A
P
Y
LN------S--D
R
E
L
V
C
I
VVPRH
P
----
E
R
-------------
F
D
E
V
F
E
-
I
C
Q
N-
L
-
N
L
----
I
T
H
R
R
S
MGQSIHAS
T
Q
V
Y
L
AD--S--M--
G
E
L
W
L
W
Y
---------
A
L
S
-
Q
V
C
FV-----GGSL------NEPGGGHNI
L
E
P
M
VLNVPTVVGPRY-F
N
F
Q
T
I
V
D
E
F
IDEN
A
---
V
L
I
A
--
Q
D
A
Q
Q
V
V
D
I
W
L
A
C
LAE
P
E
A
T
E
Q
L
V
A
Q
A
H
K
V
L
Q
R---NQ
G
---
S
L
Q
K
H
I
G
V
I
N
R
Y
L
AEKS------
1
PsiBlast_PDB
85.14
98%
-197
- C1 -
-
4BFC
2
?
A:
[25-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
I
K
Q
-----
A
A
Q
L
H
Q
Q
-
W
Y
L
E
---
N
-
R
Q
V
V
T
I
A
S
T
H
-
A
-
P
-
E
--
E
--
Q
Q
-
I
L
E
A
L
A
P
Y
L
N
------
S
--
D
R
K
L
V
C
I
V
V
P
R
H
P
----
E
R
-------------
F
D
E
V
F
E
-
I
C
Q
N
-
L
-
N
L
----
I
T
H
R
R
S
M
G
Q
S
I
H
A
S
T
Q
V
Y
L
A
D
--
S
--
M
--
G
E
L
W
L
W
Y
---------
A
L
S
-
Q
V
C
F
V
-----
G
G
S
L
------
N
E
P
G
G
G
H
N
I
L
E
P
M
V
L
N
V
P
T
V
V
G
P
R
Y
-
F
N
F
Q
T
I
V
D
E
F
I
D
E
N
A
---
V
L
I
A
--
Q
D
A
Q
Q
V
V
D
I
W
L
A
C
L
A
E
P
E
A
T
E
Q
L
V
A
Q
A
H
K
V
L
Q
R
--------------------------------
31
HHSearch
68.29
25%
-144
- C1 -
-
2XCI
6
KDTA_AQUAE
A:
[38-362]
--------------------------------------------------------------------------------------------
N
C
K
G
-
A
L
W
V
H
T
A
S
I
G
E
------
F
N
T
F
L
P
I
L
K
E
L
K
R
---
E
H
R
I
L
L
T
Y
F
S
P
R
A
R
E
Y
L
K
---
T
K
S
----
D
F
Y
D
C
-
L
H
---
P
L
P
------------
L
------------
D
N
----------------
P
F
S
V
-----
K
R
F
E
E
-
L
--
S
-
K
P
K
A
L
I
V
V
E
R
E
F
W
P
S
-------
L
-
I
---
I
----
F
T
K
V
P
K
I
L
V
N
A
Y
A
K
G
--------------------------
S
L
I
E
K
I
L
S
K
K
F
D
L
I
I
M
R
T
Q
E
D
V
--
E
K
F
K
T
F
-----
G
A
---
K
R
V
-
F
S
C
G
N
L
K
F
I
C
Q
K
G
K
-------------
G
----
I
K
L
----
K
-
G
E
F
I
V
A
G
S
I
H
-
T
-
G
-
E
--
V
--
E
I
-
I
L
K
A
F
K
E
I
K
K
------
T
--
Y
S
S
L
K
L
I
L
V
P
R
H
I
----
E
N
-------------
A
K
I
F
E
K
-
K
A
R
D
-
F
-
G
F
----
K
T
S
F
F
-----
E
N
L
E
G
D
V
I
L
V
D
--
R
--
F
--
G
I
L
K
E
L
Y
---------
P
V
G
-
K
I
A
I
V
-----
G
G
T
F
------
V
N
-
I
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
G
P
Y
T
-
H
K
V
N
D
L
K
E
F
L
E
K
E
G
A
---
G
F
E
V
--
K
N
E
T
E
L
V
T
K
L
T
E
L
L
S
V
K
K
E
I
-
K
V
E
E
K
S
R
E
I
K
G
C
--------------------------------
32
HHSearch
66.73
25%
-140
- C1 -
-
2XCI
4
KDTA_AQUAE
B:
[38-362]
--------------------------------------------------------------------------------------------
N
C
K
G
-
A
L
W
V
H
T
A
S
I
G
E
------
F
N
T
F
L
P
I
L
K
E
L
K
R
---
E
H
R
I
L
L
T
Y
F
S
P
R
A
R
E
Y
L
K
---
T
K
S
----
D
F
Y
D
C
-
L
H
---
P
L
P
------------
L
------------
D
N
----------------
P
F
S
V
-----
K
R
F
E
E
-
L
--
S
-
K
P
K
A
L
I
V
V
E
R
E
F
W
P
S
-------
L
-
I
---
I
----
F
T
K
V
P
K
I
L
V
N
A
Y
A
K
G
--------------------------
S
L
I
E
K
I
L
S
K
K
F
D
L
I
I
M
R
T
Q
E
D
V
--
E
K
F
K
T
F
-----
G
A
---
K
R
V
-
F
S
C
G
N
L
K
F
I
C
Q
K
G
K
-------------
G
----
I
K
L
----
K
-
G
E
F
I
V
A
G
S
I
H
-
T
-
G
-
E
--
V
--
E
I
-
I
L
K
A
F
K
E
I
K
K
------
T
--
Y
S
S
L
K
L
I
L
V
P
R
H
I
----
E
N
-------------
A
K
I
F
E
K
-
K
A
R
D
-
F
-
G
F
----
K
T
S
F
F
-----
E
N
L
E
G
D
V
I
L
V
D
--
R
--
F
--
G
I
L
K
E
L
Y
---------
P
V
G
-
K
I
A
I
V
-----
G
G
T
F
------
V
N
-
I
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
G
P
Y
T
-
H
K
V
N
D
L
K
E
F
L
E
K
E
G
A
---
G
F
E
V
--
K
N
E
T
E
L
V
T
K
L
T
E
L
L
S
V
K
K
E
I
-
K
V
E
E
K
S
R
E
I
K
G
C
--------------------------------
21
Fugue
63.73
25%
-27
- C1 -
-
2XCI
8
KDTA_AQUAE
A:
[20-373]
------------------------------------------------------------------
R
--------
H
M
Q
F
E
V
L
K
R
F
F
P
K
E
S
L
-
K
N
C
K
G
A
L
W
V
H
T
A
S
I
G
E
------
F
N
T
F
L
P
I
L
K
E
L
K
R
E
---
H
R
I
L
L
T
Y
F
S
P
R
A
R
E
Y
L
K
--
T
K
S
D
F
Y
-----
D
C
-
L
H
---
P
L
P
------------
L
------------
D
N
----------------
P
F
S
V
-----
K
R
F
E
E
-
L
--
S
-
K
P
K
A
L
I
V
V
E
R
E
F
W
P
S
-------
L
-
I
---
I
F
T
K
----
V
P
K
I
L
V
N
A
Y
A
K
G
S
--------------------------
L
I
E
K
I
L
S
K
K
F
D
L
I
I
M
R
T
Q
E
D
V
--
E
K
F
K
T
F
-----
G
A
-
K
--
R
V
-
F
S
C
G
N
L
K
F
I
C
Q
K
G
K
G
------------------
I
K
L
---
K
-
G
E
F
I
V
A
G
S
I
H
-
T
-
G
-
E
--
V
--
E
I
-
I
L
K
A
F
K
E
I
K
K
------
T
--
Y
S
S
L
K
L
I
L
V
P
R
H
I
----
E
N
-------------
A
K
I
F
E
K
-
K
A
R
D
-
F
-
G
F
----
K
T
S
F
F
E
-----
N
L
E
G
D
V
I
L
V
D
--
R
--
F
--
G
I
L
K
E
L
Y
---------
P
V
G
-
K
I
A
I
V
-----
G
G
T
F
------
V
-
N
I
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
G
P
Y
T
-
H
K
V
N
D
L
K
E
F
L
E
K
E
G
A
---
G
F
E
V
--
K
N
E
T
E
L
V
T
K
L
T
E
L
L
S
V
K
K
E
I
-
K
V
E
E
K
S
R
E
I
K
G
C
---
Y
L
E
---
K
L
R
E
F
L
R
G
---------------
2
PsiBlast_PDB
51.15
29%
-12
- C1 -
-
2XCI
8
KDTA_AQUAE
A:
[23-309]
-----------------------------------------------------------------------------
Q
F
E
V
L
K
R
F
F
P
K
E
S
L
-
K
N
C
K
G
A
L
W
V
H
T
A
S
I
G
E
------
F
N
T
F
L
P
I
L
K
E
-
L
K
R
--
E
H
R
I
L
L
T
Y
F
S
P
R
A
R
E
Y
L
K
--
T
---
K
S
D
F
Y
D
C
L
H
-
P
-----
L
P
------------
L
------------
D
N
----------------
P
F
S
V
-----
K
R
F
E
E
-
L
--
S
-
K
P
K
A
L
I
V
V
E
R
E
F
W
P
S
-------
L
-
I
---
I
F
T
K
----
V
P
K
I
L
V
N
A
----------
Y
--------------
A
--
K
G
S
L
I
E
K
I
L
S
K
K
F
D
L
I
I
M
R
T
Q
E
D
V
--
E
K
F
K
T
F
-----
G
A
-
K
R
V
F
S
---
C
G
N
L
K
F
I
C
Q
K
G
-----
K
-----
G
I
K
L
K
G
E
-
F
-----------
I
V
A
G
S
I
H
-
T
-
G
-
E
--
V
--
E
I
-
I
L
K
A
F
K
E
I
K
K
------
T
--
Y
S
S
L
K
L
I
L
V
P
R
H
I
----
E
N
--------------
A
K
I
F
E
---
K
K
-
A
-
R
D
----
F
G
F
K
T
S
F
F
E
N
L
E
G
D
--
V
I
L
V
D
--
R
--
F
--
G
I
L
K
E
L
Y
---------
P
V
G
-
K
I
A
I
V
-----
G
G
T
F
------
V
N
I
-
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
G
P
--------------------------------------------------------------------------------------------
3
PsiBlast_PDB
50.75
29%
-13
- C1 -
-
2XCU
6
KDTA_AQUAE
A:
[23-309]
-----------------------------------------------------------------------------
Q
F
E
V
L
K
R
F
F
P
K
E
S
L
-
K
N
C
K
G
A
L
W
V
H
T
A
S
I
G
E
------
F
N
T
F
L
P
I
L
K
E
-
L
K
R
--
E
H
R
I
L
L
T
Y
F
S
P
R
A
R
E
Y
L
K
--
T
---
K
S
D
F
Y
D
C
L
H
-
P
-----
L
P
------------
L
------------
D
N
----------------
P
F
S
V
-----
K
R
F
E
E
-
L
--
S
-
K
P
K
A
L
I
V
V
E
R
E
F
W
P
S
-------
L
-
I
---
I
F
T
K
----
V
P
K
I
L
V
N
A
----------
Y
--------------
A
--
K
G
S
L
I
E
K
I
L
S
K
K
F
D
L
I
I
M
R
T
Q
E
D
V
--
E
K
F
K
T
F
-----
G
A
-
K
R
V
F
S
---
C
G
N
L
K
F
I
C
Q
K
G
-----
K
-----
G
I
K
L
K
G
E
-
F
-----------
I
V
A
G
S
I
H
-
T
-
G
-
E
--
V
--
E
I
-
I
L
K
A
F
K
E
I
K
K
------
T
--
Y
S
S
L
K
L
I
L
V
P
R
H
I
----
E
N
--------------
A
K
I
F
E
---
K
K
-
A
-
R
D
----
F
G
F
K
T
S
F
F
E
N
L
E
G
D
--
V
I
L
V
D
--
R
--
F
--
G
I
L
K
E
L
Y
---------
P
V
G
-
K
I
A
I
V
-----
G
G
T
F
------
V
N
I
-
G
G
H
N
L
L
E
P
T
C
W
G
I
P
V
I
Y
G
P
--------------------------------------------------------------------------------------------
25
Fugue
49.52
13%
-67
- C1 -
-
4XSO
2
?
A:
[7-384]
------------------------
M
K
I
L
------------
F
L
-
D
Q
S
G
--------------
K
P
G
G
A
E
--------
L
C
L
I
D
I
A
K
P
Y
-----
R
-
D
R
A
L
-
V
G
L
F
---------------
A
D
G
A
F
K
T
L
L
E
Q
H
--
H
I
P
V
E
V
F
T
N
Q
P
S
L
G
Q
--------------------------
L
------------
A
------------
P
L
----------------
V
A
K
V
-----
V
Q
T
A
H
------
E
Y
D
L
I
Y
A
N
T
Q
K
A
L
V
V
-------
G
-
A
---
I
A
S
F
-
I
A
R
R
P
L
V
Y
H
L
H
D
I
L
S
P
E
H
F
-
S
Q
--------------
T
--
N
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
S
Q
A
S
Q
--
T
A
F
I
Q
A
-----
G
G
-
R
A
E
L
T
-
K
V
I
Y
N
G
-
F
D
I
N
L
Y
K
T
S
P
S
D
-----
I
S
K
L
R
Q
Q
-
L
G
V
A
---
N
-
N
F
V
V
G
H
F
S
R
L
-
S
-
P
-
W
KG
Q
--
H
I
-
L
I
D
A
L
A
Q
C
P
P
------
Q
--
V
T
A
I
L
V
G
D
A
L
F
G
E
----
Q
D
-------------
Y
V
K
E
L
H
Q
Q
I
T
R
-
L
-
G
L
----
E
N
R
V
K
F
L
G
F
R
A
D
I
P
Q
L
M
A
A
C
D
------------------------------
L
V
A
-----
H
T
S
T
------
A
P
E
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
A
A
K
------
A
G
G
A
M
E
L
V
E
H
G
V
N
G
F
L
T
T
P
--
G
E
S
Q
E
L
A
N
I
I
N
T
C
I
E
D
T
Q
K
T
A
T
I
A
S
N
A
Q
A
I
A
S
Q
---
R
F
----
D
V
V
T
I
N
Q
Q
I
A
E
T
L
S
S
L
-------
29
Fugue
43.45
20%
-4
- C1 -
-
4RAP
-
TIBC_ECOH1
A:
[10-391]
------------------------
I
T
P
P
DTPT
Q
A
G
P
EN
I
F
Y
D
-
F
N
D
G
A
R
V
L
L
P
E
G
K
W
H
V
R
L
L
D
A
D
S
E
--------
N
I
L
F
C
C
D
V
D
K
G
W
V
T
S
S
K
K
Y
F
V
-
R
F
R
I
Q
V
F
R
Q
G
A
------
T
----
P
L
L
D
E
T
L
K
L
K-
D
R
P
V
L
I
S
F
P
T
G
T
----
L
G
--
D
L
L
G
W
F
P
Y
A
E
R
F
Q
-
S
L
---
H
------------------------------------------------------
K
C
R
L
E
-
C
--
T
M
S
Q
D
I
I
D
L
L
A
P
Q
-
Y
P
Q
-------
I
-
Q
F
S
T
P
D
K
P
-
R
T
V
A
P
Y
A
T
Y
R
V
G
L
Y
F
G
G
D
T
-
N
N
--------------
Q
--
P
V
D
F
R
K
V
G
F
H
R
S
A
G
Y
I
L
G
V
D
P
--
R
--
E
A
P
V
R
L
-----
D
L
-
S
A
P
R
V
----------
I
A
A
P
Y
V
C
I
A
T
-----
Q
S
T
C
Q
A
K
Y
W
N
N
G
---
T
-
G
W
S
E
V
I
A
H
L
K
-
S
-
L
-
G
--
Y
--
R
V
M
C
I
D
R
D
A
H
Y
-----------
G
Q
G
F
V
W
N
H
I
P
W
G
A
----
E
D
-------------
F
T
G
K
L
P
-
L
Q
E
R
-
V
-
N
L
----
L
R
H
-----------
A
S
F
F
I
G
L
--
P
--
S
--
G
L
S
W
L
A
W
---------
A
T
R
I
P
V
V
L
I
-----
S
G
F
---------------
S
L
P
N
S
E
F
Y
T
P
----
W
R
V
-
F
N
S
H
G
C
Y
G
C
W
D
D
T
S
L
---
N
F
D
H
--
H
D
F
-----
L
W
C
P
R
H
K
N
T
D
R
Q
F
E
C
T
R
L
I
---------------
T
G
A
Q
V
N
G
V
I
N
K
L
H
R
S
L
T
------
34
HHSearch
41.47
13%
-21
* C1 *
-
4XSO
2
?
B:
[89-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
Q
T
A
--
H
-
E
Y
D
L
I
Y
A
N
T
Q
K
A
L
V
V
-------
G
-
A
---
I
A
S
F
-
I
A
R
R
P
L
V
Y
H
L
H
D
I
L
S
P
E
H
F
-
S
Q
--------------
T
--
N
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
S
Q
A
S
Q
--
T
A
F
I
Q
A
-----
G
G
-
R
A
E
L
T
-
K
V
I
Y
N
G
F
D
I
N
L
Y
K
T
S
P
S
-
D
-----
I
S
K
L
R
Q
Q
-
L
G
V
A
N--
N
-
F
V
V
G
H
F
S
R
L
S
-
P
-
W
K
G
--
Q
--
H
I
-
L
I
D
A
L
A
Q
C
P
-----------
P
Q
V
T
A
I
L
V
G
D
A
L
FGEQ
D
Y
-------------
V
K
E
L
H
Q
-
Q
I
T
R
-
L
-
G
L
----
E
-------------
N
R
V
K
F
L
G
--
F
--
R
--
A
D
I
P
Q
L
M
---------
A
A
C
-
D
L
V
A
H
-----
T
S
T
A
------
P
E
-
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
-
A
A
K
A
-
G
G
A
M
E
L
V
E
H
-
G
V
N
G
F
---
L
T
T
P
--
G
E
S
Q
E
L
A
N
I
I
N
T
C
I
E
D
T
Q
K
T
A
T
I
A
S
N
A
Q
A
I
A
S
Q
---
R
F
D
VVT
I
N
Q
Q
I
A
E
T
L
S
S
L
-----------
40
HHSearch
41.30
15%
-25
- C1 -
-
4N9W
2
PIMA_MYCS2
A:
[18-368]
--------------------------------------------------------------------------------------------------------
P
G
G
V
------
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
--
G
H
E
V
S
V
L
A
P
A
S
P
H
V
K
L
P
D
---
Y
V
V
-----
S
G
G
K
-
A
V
---
P
I
P
YNGSVAR
L
R
F
G
-
P
------------
A
T
----------------
H
R
K
V
-----
K
K
W
I
A
-
E
--
G
-
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
-------
S
-
M
---
L
A
L
Q
-
A
A
E
G
P
I
V
A
T
F
H
T
S
T
T
K
S
L
T
-
L
S
-----------------
V
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
------------------------
A
-
V
E
I
P
N
G
V
D
V
A
S
F
A
D
A
P
L
-----------
L
D
G
-
Y
P
R
E
---
G
-
R
T
V
L
F
L
G
R
Y
D
E
P
-
R
K
G
--
M
--
A
V
-
L
L
A
A
L
P
K
L
V
A
------
R
--
F
P
D
V
E
I
L
I
V
G
R
G
D
----
E
---------------
D
E
L
R
E
-
Q
A
G
D
-
L
-------
A
-------------
G
H
L
R
F
L
G
--
Q
VD
D
--
A
T
K
A
S
A
M
---------
R
S
A
-
D
V
Y
C
A
-----
P
H
L
G
------
G
E
-
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
-
A
S
D
L
-
D
A
F
R
R
V
L
A
D
-
G
D
A
G
R
---
L
V
P
V
--
D
D
A
D
G
M
A
A
A
L
I
G
I
L
E
D
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
H
----
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
----------
26
Fugue
39.15
10%
-42
- C1 -
-
3OKP
1
PIMB_CORGL
A:
[4-381]
--------------------------------------------------------------
S
R
K
T
L
--------
V
V
T
N
D
F
P
P
R
I
G
--------------------
G
I
------
Q
S
Y
L
R
D
F
I
A
T
Q
D
P
E
--
S
I
V
V
F
A
S
T
Q
N
A
E
E
A
H
A
Y
D
--
K
T
L
D
Y
E
V
I
R
W
P
R
S
-
V
M
---
L
P
T
------------
P
------------
T
T
----------------
A
H
A
M
-----
A
E
I
I
R
-
E
--
R
-
E
I
D
N
V
W
F
G
A
A
A
P
L
A
L
-------
M
-
A
---
G
T
A
K
-
Q
A
G
A
S
K
V
I
A
S
T
H
G
H
E
V
G
W
S
-
M
L
--------------
P
--
G
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
S
Q
Y
T
L
--
R
R
F
K
S
A
F----
G
S
-
H
P
T
F
E
-
H
L
P
S
G
V
D
V
K
R
F
T
P
A
T
P
E
D
K
-----
S
A
T
R
K
K
L
-
G
F
T
D
---
T
-
T
P
V
I
A
C
N
S
R
L
-
V
-
P
-
R
--
K
G
Q
D
S
-
L
I
K
A
M
P
Q
V
I
A
------
A
--
R
P
D
A
Q
L
L
I
V
G
S
G
R
----
Y
----------------------------------
E
S
T
L
R
R
L
A
T
D
V
S
Q
N
V
K
F
L
G
R
L
--
E
--
Y
--
Q
D
M
I
N
T
L
---------
A
A
A
-
D
I
F
A
M
P
A
R
T
R
G
G
G
L
------
D
V
E
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
A
G
T
------
S
G
G
A
P
E
T
V
T
P
A
T
---
G
L
V
V
EG
S
D
V
D
K
L
S
E
L
L
I
E
L
L
D
D
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
E
A
---
E
W
S
---
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
------
56
HHSearch
38.71
14%
-2
- C1 -
-
1V4V
2
?
A:
[8-367]
--------------------------------------------------------------------------------------------------
V
V
L
A
F
G
T
R
P
E
------
A
T
K
M
A
P
V
Y
L
A
L
R
G
I
P-
G
L
K
P
L
V
L
L
T
G
Q
H
R
E
Q
L
R
Q
---
A
L
S
-
L
---
F
G
I
Q
-
E
D
R--
N
L
D
VMQERQA
L
P
D
L
A
A
------------
R
I
----------------
L
P
Q
A
-----
A
R
A
L
K
-
E
--
M
-
G
A
D
Y
V
L
V
H
G
D
T
L
T
T
F
A
------
V
-
A
---
W
A
A
F
-
L
E
G
I
P
V
G
H
V
E
A
G
L
R
S
G
N
L
K
-
E
P
--------------
F
--
P
E
E
A
N
R
R
L
T
D
V
L
T
D
L
D
F
A
P
T
P
L
A
K
--
A
N
L
L
K
E
-----
G
K
-
R
E
E
G
I
-
L
V
T
G
Q
T
G
V
D
A
V
L
L
A
A
K
L
----------
G
R
L
P
-
E
G
L
P
EG-
P
-
Y
V
T
V
T
M
H
R
R
E
-
N
-
W
P
L
--
L
--
S
D
-
L
A
Q
A
L
K
R
V
A
E
------
A
--
F
P
H
L
T
F
V
Y
P
V
H
L
N
----
P
V
V
------------
R
E
A
V
F
P
-
V
L
K
----------------------
G
V
R
N
F
V
L
L
D
--
P
LE
Y
--
G
S
M
A
A
L
M
---------
R
A
S
-
L
L
L
V
T
-----
D
S
-----------
G
--
G
L
Q
E
E
G
A
A
L
G
V
P
V
V
V
L
R
N
V
-
T
E
R
P
E
G
L
K
A
--
G
I
L
K
---
L
A
G
---
T
D
P
E
G
V
Y
R
V
V
K
G
L
L
E
N
P
E
E
L
S
R
M
R
K
A
K
N
P
Y
G
D
-----
G
K
---
A
G
L
M
V
A
R
G
V
A
W
R
L
G
L
--------
35
HHSearch
37.50
13%
-23
- C1 -
-
4XSU
3
?
A:
[89-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
V
Q
T
A
--
H
-
E
Y
D
L
I
Y
A
N
T
Q
K
A
L
V
V
-------
G
-
A
---
I
A
S
F
-
I
A
R
R
P
L
V
Y
H
L
H
D
I
L
S
P
E
H
F
-
S
Q
--------------
T
--
N
L
R
V
A
V
N
L
A
N
R
F
A
S
L
V
I
A
N
S
Q
A
S
Q
--
T
A
F
I
Q
A
-----
G
G
-
R
A
E
L
T
-
K
V
I
Y
N
G
F
D
I
N
L
Y
K
T
S
P
S
-
D
-----
I
S
K
L
R
Q
Q
-
L
G
V
A
N--
N
-
F
V
V
G
H
F
S
R
L
S
-
P
-
W
K
G
--
Q
--
H
I
-
L
I
D
A
L
A
Q
C
P
-----------
P
Q
V
T
A
I
L
V
G
D
A
L
FGE
Q
D
Y
-------------
V
K
E
L
H
Q
-
Q
I
T
R
-
L
-
G
L
----
E
-------------
N
R
V
K
F
L
G
--
F
--
R
--
A
D
I
P
Q
L
M
---------
A
A
C
-
D
L
V
A
H
-----
T
S
T
A
------
P
E
-
P
F
G
R
V
I
V
E
A
M
L
C
G
K
P
V
V
-
A
A
K
A
-
G
G
A
M
E
L
V
E
H
-
G
V
N
G
F
---
L
T
T
P
--
G
E
S
Q
E
L
A
N
I
I
N
T
C
I
E
D
T
Q
K
T
A
T
I
A
S
N
A
Q
A
I
A
S
Q
---
R
F
D
V
V
T
I
N
Q
Q
I
A
E
T
L
S
S
L
-----------
52
HHSearch
36.76
9%
-0
- C1 -
-
4HWG
-
?
A:
[9-376]
----------------------------------------------------------------------------------------------
M
L
-
K
V
M
T
I
V
G
T
R
P
E
------
L
I
K
L
C
C
V
I
S
E
F
D
K
H
T-
K
H
I
L
V
H
T
G
Q
N
Y
A
Y
-
E
L
N
Q
--
V
F
F
D
-----
M
G
I
R
-
K
P
---
D
Y
F
------------
L
EVAADNT
A
K
S
I
G
L
V
----------------
I
E
K
V
-----
D
E
V
L
E
-
K
--
E
-
K
P
D
A
V
L
F
Y
G
D
T
N
S
C
L
-------
S
-
A
---
I
A
A
K
-
R
R
K
I
P
I
F
H
M
E
A
G
N
R
C
F
D
Q
R
-
V
P
------------------
E
E
I
N
R
K
I
I
D
H
I
S
D
V
N
I
T
L
T
E
H
A
R
--
R
Y
L
I
A
E
-----
G
L
-
P
A
E
L
T
-
F
K
S
G
S
H
M
P
E
V
L
D
R
F
M
P
K
I
L
-----
K
S
D
I
L
D
K
-
L
S
L
T
P--
K
Q
Y
F
L
I
S
S
H
R
E
---K
N
-
N
--
L
--
K
E
-
L
L
N
S
L
Q
M
L
I
K
------
E
--
Y
-
N
F
L
I
I
F
S
T
H
P
R
----
T
K
--------------
K
R
L
E
--
D
L
E
G
-
F
K
E
L
----
G
-------------
D
K
I
R
F
L
P
--
A
FS
F
--
T
D
Y
V
K
L
Q
---------
M
N
A
-
F
C
I
L
S
-----
D
S
-------------
G
T
I
T
E
E
A
S
I
L
N
L
P
A
L
-
N
I
R
E
A
H
E
R
P
E
G
M
D
A
--
G
T
L
I
---
M
S
G
F
---
K
A
E
R
V
L
Q
A
V
K
T
I
T
E
E
H
D
N
N
K
R
T
Q
G
L
V
P
D
Y
N
E
A
----
G
L
---
V
S
K
K
I
L
R
I
V
L
S
Y
V
D
Y
--------
22
Fugue
36.26
12%
-39
- C1 -
-
2GEK
1
PIMA_MYCS2
A:
[21-393]
---------------------------------------------------------------
M
R
I
G
--------
M
V
C
P
Y
S
F
D
V
P
G
--------------------
G
V
------
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
--
G
H
E
V
S
V
L
A
P
A
S
P
H
V
K
L
P
D
--
Y
V
V
S
G
G
K
--------
A
---
V
F
G
------------
P
------------
A
T
----------------
H
R
K
V
-----
K
K
W
I
A
-
E
--
G
-
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
-------
S
-
M
---
L
A
L
Q
-
A
A
E
G
P
-
I
V
A
T
F
H
T
S
T
T
K
S
L
-
T
L
--------------
S
--
V
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
--
R
W
Q
M
E
A
-----
L
G
-
S
---------
D
A
V
E
I
P
N
G
V
D
V
A
S
F
A
-----
D
A
P
L
L
D
G
-
Y
P
R
E
---
G
-
R
T
V
L
F
L
G
R
Y
D
-
E
-
P
-
R
--
K
G
M
A
V
-
L
L
A
A
L
P
K
L
V
A
------
R
--
F
P
D
V
E
I
L
I
V
G
R
G
D
-----------------------------------------
E
D
E
L
R
E
Q
A
G
D
L
A
G
H
L
R
F
L
G
QV
D
--
D
--
A
T
K
A
S
A
M
---------
R
S
A
-
D
V
Y
C
A
-----
P
H
L
G
------
G
E
S
F
G
-
I
V
L
V
E
A
M
A
A
G
T
A
V
V
A
S
D
------
L
D
A
F
R
R
V
L
A
D
G
D
A
G
R
L
V
P
V
--
D
D
A
D
G
M
A
A
A
L
I
G
I
L
E
D
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
H
R
Y--
D
W
S
---
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
G
A
G
I
K
V
Q
V
S
55
HHSearch
35.28
12%
19
- C1 -
-
3OT5
-
?
B:
[25-393]
--------------------------------------------------------------------------------------------
M
A
K
I
-
K
V
M
S
I
F
G
T
R
P
E
------
A
I
K
M
A
P
L
V
L
A
L
E
K
E
PE
T
F
E
S
T
V
V
I
T
A
Q
H
R
E
M
L
-
D
--
Q
V
L
E
-
I
---
F
D
I
K
P
D
I
D
L
D
I
M
K
GQT
L
A
E
I
T
----
S
------------
R
V
----------------
M
N
G
I
-----
N
E
V
I
A
-
A
--
E
-
N
P
D
I
V
L
V
H
G
D
T
T
T
S
F
-------
A
A
G
---
L
A
T
F
-
Y
Q
Q
K
M
L
G
H
V
E
A
G
L
R
T
W
N
K
Y
S
P
F
-----------------
P
E
E
M
N
R
Q
L
T
G
V
M
A
D
I
H
F
S
P
T
K
Q
A
K
--
E
N
L
L
A
E
-----
G
K
-
D
P
A
T
I
-
F
V
T
G
N
T
A
I
D
A
L
K
T
T
V
Q
K
D
Y
-----
H
H
P
I
L
E
---
N
L
G
D--
N
R
L
I
L
M
T
A
H
R
R
E
-
N
L
G
E
P
--
M
--
Q
G
-
M
F
E
A
V
R
E
I
V
E
------
S
--
R
E
D
T
E
L
V
Y
P
M
H
L
N
----
P
A
----------------
V
R
E
-
K
A
M
A
I
L
-
G
G
-----------------
H
E
R
I
H
L
I
E
--
P
--
L
D
A
I
D
F
H
N
F
L
---------
R
K
S
-
Y
L
V
F
T
-----
D
S
-------------
G
G
V
Q
E
E
A
P
G
M
G
V
P
V
L
V
L
R
D
T
-
T
E
R
P
E
G
I
E
A
-
G
T
L
K
-----
L
I
G
--
T
N
K
E
N
L
I
K
E
A
L
D
L
L
D
N
K
E
S
H
D
K
M
A
Q
A
A
N
P
Y
G
D
-----
G
F
---
A
A
N
R
I
L
A
A
I
K
S
H
F
E
---------
30
Fugue
34.08
15%
16
- C1 -
-
4X7P
-
?
A:
[1-493]
M
K
K
I
F
M
M
V
HELDVNKG
G
M
T
S
S
M
F
N
R
S
K
E
------------
F
Y
D
A
D
I
P
A
D
I
V
T
F
D
Y
K
G
N
Y
D
E
I
I
K
A
L
K
K
Q
GKMDRR
T
K
M
Y
N
V
F
E
Y
F
K
Q
I
S
N
N
-
K
H
F
K
-
S
N
K
L
L
Y
K
H
I
S
E
R
L
KN
T
I
E
I
E
E
S
K
G
I
S
R
Y
F
D
I
--
T
T
G
T
Y
I
A
Y
I
R
K
S
K
S
E
K
V
I
--
D
F
F
K
D
N
K
R
I
E
R
F
S
-
F
I
---
D
N
K
------------
V
------------
H
M
----------------
K
E
T
F
N
VDNK
V
C
Y
Q
V
-
F
--
Y
-
D
E
K
G
Y
P
Y
I
S
R
N
I
N
A
N
NGAV
G
K
T
Y
-
V
---
L
V
N
K
-
K
E
F
K
N
N
L
A
L
C
V
Y
Y
L
E
K
L
I
K
-
D
---------------
S
--
K
D
S
I
M
I
C
D
G
P
G
S
F
P
K
M
F
N
T
N
H
K
N
A
--
Q
K
Y
G
V
I
-----
H
V
-
N
H
H
E
N
F
D
D
T
G
A
F
K
---
K
S
E
K
Y
I
I
E
N
-----
A
N
K
I
N
G
V
-
I
V
L
T
---
E
-
A
Q
R
L
D
I
L
N
Q
F
-
D
-
V
-
E
--
N
--
I
F
-
T
I
S
N
F
V
K
I
H
N
APKHFQ
T
--
E
K
I
V
G
H
I
S
R
M
V
P
T
----
K
R
-------------
I
D
L
L
I
E
-
V
A
E
L
-
V
-
V
K
K
DNA
V
K
F
H
I
Y
G
E
G
S
V
K
D
K
I
A
K
M
I
E
D
--
K
--
N
--
L
E
R
N
V
F
L
KGYTTT
P
Q
K
C
L
E
-
D
F
K
L
V
-----
V
S
T
S
------
Q
Y
E
G
Q
G
L
S
M
I
E
A
M
I
S
K
R
P
V
V
A
F
D
I
K
-
Y
G
----
P
S
D
F
I
E
D
N
K
NGY
L
I
E
N
--
H
N
I
N
D
M
A
D
K
I
L
Q
L
V
N
N
D
V
L
A
A
E
F
G
S
K
A
R
E
N
I
I
E
K
Y
S
T
E
S
---
I
L
E
K
W
L
N
L
F
N
S
------------
39
HHSearch
33.29
15%
-
- C1 -
-
4NC9
-
PIMA_MYCS2
A:
[14-364]
--------------------------------------------------------------------------------------------------------
P
G
G
V
------
Q
S
H
V
L
Q
L
A
E
V
L
R
D
A
--
G
H
E
V
S
V
L
A
P
A
S
P
H
V
K
L
P
D
---
Y
V
V
-----
S
G
G
K
-
A
V
------A
R
L
R
F
G
------
P
------------
A
T
----------------
H
R
K
V
-----
K
K
W
I
A
-
E
--
G
-
D
F
D
V
L
H
I
H
E
P
N
A
P
S
L
-------
S
-
M
---
L
A
L
Q
-
A
A
E
G
P
I
V
A
T
F
H
T
S
T
T
K
S
L
T
-
L
S
-----------------
V
F
Q
G
I
L
R
P
Y
H
E
K
I
I
G
R
I
A
V
S
D
L
A
R
--
R
W
Q
M
E
A
-----
L
---
G
S
D
A
-
V
E
I
P
N
G
V
D
V
A
S
F
A
D
A
P
L
-----------
L
D
G
-
Y
P
R
E
---
G
-
R
T
V
L
F
L
G
R
Y
D
E
P
-
R
K
G
--
M
--
A
V
-
L
L
A
A
L
P
K
L
V
A
------
R
--
F
P
D
V
E
I
L
I
V
G
R
G
D
----
E
---------------
D
E
L
R
E
-
Q
A
G
D
-
L
-------
A
-------------
G
H
L
R
F
L
G
--
Q
VD
D
--
A
T
K
A
S
A
M
---------
R
S
A
-
D
V
Y
C
A
-----
P
H
L
G
------
G
E
-
S
F
G
I
V
L
V
E
A
M
A
A
G
T
A
V
V
-
A
S
D
L
-
D
A
F
R
R
V
L
A
D
-
G
D
A
G
R
---
L
V
P
V
--
D
D
A
D
G
M
A
A
A
L
I
G
I
L
E
D
D
Q
L
R
A
G
Y
V
A
R
A
S
E
R
V
H
----
R
Y
D
W
S
V
V
S
A
Q
I
M
R
V
Y
E
T
V
S
----------
51
HHSearch
32.67
12%
34
- C1 -
-
2R60
-
?
A:
[32-461]
--------------------------------------------------------------------------------------------------------
F
G
G
Q
------
L
V
Y
V
K
E
V
S
L
A
L
A
E
M
--
G
V
Q
V
D
I
I
T
R
R
I
K
D
E
N
W
P
E
FS
G
E
I
D
Y
Y
Q
E
T
N
K
V
R
-
I
V
---
R
I
P
------------
F
------------
G
G
DKFLPKEELWPY
L
H
E
Y
V
N
K
I
-----
I
N
F
Y
R
-
E
E
G
K
-
F
P
Q
V
V
T
T
H
Y
G
D
G
G
L
A
-------
G
-
V
---
L
L
K
N
-
I
K
G
L
P
F
T
F
T
G
H
S
L
G
A
Q
K
M
E
-
K
L
NVNTSNF
K
E
M
D
E
R
F
K
F
H
R
R
I
I
A
E
R
L
T
M
S
Y
A
D
K
I
I
V
S
T
S
Q
E
R
F
G
Q
Y
S
H
D
L
YRGAV
N
V
E
D
D
D
K
F
-
S
V
I
P
P
G
V
N
T
R
V
F
D
G
E
Y
G
D
K
I
K
A
K
I
T
K
Y
L
E
R
D
-
L
G
S
E
RME
L
-
P
A
I
I
A
S
S
R
L
D
-
Q
-
K
K
N
--
H
--
Y
G
-
L
V
E
A
Y
V
Q
N
K
E
------
L
Q
D
K
A
N
L
V
L
T
L
R
G
I
E
N
----
P
F
EDYSRAG
Q
E
E
K
E
I
L
G
K
I
I
E
-
L
I
D
N
-
N
-
D
C
-----------------
R
G
K
V
S
M
F
P
--
L
NS
Q
--
Q
E
L
A
G
C
Y
A
Y
L
A
-----
S
K
G
-
S
V
F
A
L
-----
T
S
F
Y
------
E
--
P
F
G
L
A
P
V
E
A
M
A
S
G
L
P
A
V
-
V
T
R
N
-
G
G
P
A
E
I
L
D
G
-
G
K
Y
G
V
---
L
V
D
P
--
E
D
P
E
D
I
A
R
G
L
L
K
A
F
E
S
E
E
T
W
S
A
Y
Q
E
K
G
K
Q
R
V
E
E
---
R
Y
T
W
Q
E
T
A
R
G
Y
L
E
V
I
Q
E
I
A
D
---------
41
HHSearch
32.66
8%
-17
- C1 -
-
3OKP
1
PIMB_CORGL
A:
[77-381]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
-----
A
E
I
I
R
-
E
--
R
-
E
I
D
N
V
W
F
G
A
A
A
P
L
A
L
-------
M
-
A
---
G
T
A
K
Q
A
G
A
S
K
V
I
A
S
T
H
G
H
E
V
G
W
S
M
-
L
P
-----------------
G
S
R
Q
S
L
R
K
I
G
T
E
V
D
V
L
T
Y
I
S
Q
Y
T
L
--
R
R
F
K
S
A
-----
F
G
-
S
H
P
T
F
-
E
H
L
P
S
G
V
D
V
K
R
F
T
P
A
T
P
E
D
-----
K
S
A
T
R
K
K
-
L
G
F
T
DT-
T
-
P
V
I
A
C
N
S
R
L
V
-
P
-
R
K
G
--
Q
--
D
S
-
L
I
K
A
M
P
Q
V
I
A
------
A
--
R
P
D
A
Q
L
L
I
V
G
S
G
R
----
Y
E
--------------
S
T
L
R
R
-
L
A
T
D
----
V
----
S
-------------
Q
N
V
K
F
L
G
--
R
--
L
E
Y
Q
D
M
I
N
T
L
---------
A
A
A
-
D
I
F
A
M
-----
P
A
R
T
R
GGGLD
V
E
-
G
L
G
I
V
Y
L
E
A
Q
A
C
G
V
P
V
I
-
A
G
T
S
-
G
G
A
P
E
T
V
T
P
--
A
T
G
L
---
V
V
E
G
--
S
D
V
D
K
L
S
E
L
L
I
E
L
L
D
D
P
I
R
R
A
A
M
G
A
A
G
R
A
H
V
E
A
---
E
W
S
W
E
I
M
G
E
R
L
T
N
I
L
Q
S
E
P
R
---------