@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTL6: (2017-12-14 )
MFISFEGTEGVGKTTLIRKIHQHFEEQGKQVVLTREPGGTPLAEQIRSMLLAVNHDENMSHDTELLLIYAARAQHLQQVILPALESNKIVLSDRFTDASFAYQCSGRGLSQDKLQLLNQNFVSRMPEVTFWLDAPIELGMNRARERGALDRFEQEKLSFFTKVREGYETLWKAEPERIKRLDATQSPDQVFEQALQYLA
Atome Classification :
(58 SA)
--.........10.......----.20......----.-.30....-....40........50....--....60........70........80........90........100.......110.......120--..--.----....130.......140-.......---150........160.......170.......180.......190.......-------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--
M
F
I
S
FEGTEGV
G
K
T
T
L
I
R
----
K
I
H
Q
H
F
E
EQ----G-
K
Q
V
V
L
T
R-EPGGT
P
L
A
E
Q
I
R
S
M
L
L
AVNH--DENMSHD
T
E
L
L
L
I
Y
A
A
R
A
Q
H
L
Q
Q
V
I
L
P
ALESN
K
I
V
L
SDRFTD
A
S
F
A
Y
Q
CSGRGL
S
Q
D
K
L
Q
L
L
N
Q
N
F
V
--
S
R--M----P
E
V
T
F
W
LDA
P
I
E
L
G
M
N
R
-
A
R
E
RGA
L
---
D
R
-
F
E
Q
E
K
L
S
F
F
T
K
V
R
E
G
Y
E
T
L
WKA
E
P
E
R
I
K
RLDATQ
S
P
D
Q
V
F
E
Q
A
L
Q
YLA-------
100
HHSearch
69.85
48%
-40
- C2 -
-
4EDH
3
KTHY_PSEAE
A:
[7-204]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
D
---
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G-
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
L
--------
101
HHSearch
67.51
48%
-39
- C2 -
-
4EDH
3
KTHY_PSEAE
B:
[7-204]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
D
---
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
E
S
F
V
Q
G-
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
----
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
G
L
P
L
A
E
V
Q
A
G
L
D
R
L
L
--------
27
PsiBlast_CBE
66.83
51%
-37
- C2 -
-
3UXM
1
KTHY_PSEAE
B:
[3-185]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
-----
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
3
PsiBlast_PDB
66.65
51%
-46
- C2 -
-
4GMD
2
KTHY_PSEAE
A:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
------
A
R
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
25
PsiBlast_CBE
66.56
51%
-33
- C2 -
-
3UXM
1
KTHY_PSEAE
D:
[3-185]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
102
HHSearch
66.11
38%
-30
- C2 -
-
4MQB
1
KTHY_STAAM
B:
[6-201]
--
A
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
H
R
L
V
K
-----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
N
-
G
L
--
Y
----
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
-
I
I
K
N
S
R
D
---
Q
N
R
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
T
I
--------
1
PsiBlast_PDB
65.35
51%
-31
- C2 -
-
4EDH
3
KTHY_PSEAE
A:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
29
PsiBlast_CBE
65.13
51%
-42
- C2 -
-
3UWO
1
KTHY_PSEAE
B:
[12-194]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
Q
G
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
-------------
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
2
PsiBlast_PDB
64.95
51%
-43
- C2 -
-
4ESH
1
KTHY_PSEAE
A:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-----
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
24
PsiBlast_CBE
64.61
51%
-39
- C2 -
-
4EDH
3
KTHY_PSEAE
B:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
----
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
5
PsiBlast_PDB
64.58
51%
-40
- C2 -
-
3UWK
1
KTHY_PSEAE
A:
[24-206]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
--
Q
G
DL
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
------
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
6
PsiBlast_PDB
64.56
51%
-47
- C2 -
-
3UWO
1
KTHY_PSEAE
A:
[12-194]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
Q
G
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
------------
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
28
PsiBlast_CBE
64.15
51%
-49
- C2 -
-
3UWK
1
KTHY_PSEAE
B:
[24-206]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
--
Q
G
DL
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
--------------
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
21
PsiBlast_CBE
63.86
51%
-37
- C2 -
-
4GMD
1
KTHY_PSEAE
D:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
-------------
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
23
PsiBlast_CBE
63.85
51%
-36
- C2 -
-
4GMD
3
KTHY_PSEAE
B:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
----------------
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
117
HHSearch
63.72
37%
-39
- C2 -
-
5H56
3
?
B:
[1-189]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
E
------
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
F
A
T
R-
G
V
--
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
N
R
F
---
E
----
N
K
--
E
F
L
E
K
V
R
K
G
F
L
E
L
A
K
E
E
-
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
--------
61
PsiBlast_CBE
63.68
37%
-14
- C2 -
-
5XAI
1
?
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
116
HHSearch
63.53
37%
-32
- C2 -
-
4S35
3
KTHY_AQUAE
A:
[1-189]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
E
------
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
F
A
T
R
-
G
V
--
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
N
R
F
---
E
----
N
K
--
E
F
L
E
K
V
R
K
G
F
L
E
L
A
K
E
E
-
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
--------
7
PsiBlast_PDB
63.43
50%
-38
- C2 -
-
4E5U
1
KTHY_PSEAE
A:
[7-189]
--
L
F
V
T
L
E
G
P
E
----
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
-
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
35
PsiBlast_CBE
63.33
38%
-14
- C2 -
-
4DWJ
1
KTHY_STAAM
D:
[28-220]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
R
D
Q
---
N
R
-
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
---
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
63
PsiBlast_CBE
63.32
37%
-15
- C2 -
-
5H5K
5
?
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
26
PsiBlast_CBE
63.25
51%
-40
- C2 -
-
3UXM
1
KTHY_PSEAE
C:
[3-185]
--
L
F
V
T
L
E
G
P
E
G
A
---
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
----
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
66
PsiBlast_CBE
63.24
37%
-18
- C2 -
-
5H56
3
?
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
52
PsiBlast_CBE
63.18
37%
-15
- C2 -
-
2CCG
1
KTHY_STAAM
A:
[24-218]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
R
D
Q
---
N
R
-
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
T
I
--------
56
PsiBlast_CBE
63.10
37%
-11
- C2 -
-
5XB3
2
?
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
31
PsiBlast_CBE
63.06
38%
-19
- C2 -
-
4EAQ
1
KTHY_STAAM
B:
[28-220]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
----------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
57
PsiBlast_CBE
63.04
37%
-16
- C2 -
-
5XB3
2
?
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
69
PsiBlast_CBE
62.85
37%
-10
- C2 -
-
4S35
3
KTHY_AQUAE
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
60
PsiBlast_CBE
62.83
37%
-15
- C2 -
-
5XAI
1
?
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
59
PsiBlast_CBE
62.82
37%
-12
- C2 -
-
5XB2
2
?
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
67
PsiBlast_CBE
62.81
37%
-15
- C2 -
-
5H56
3
?
A:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
62
PsiBlast_CBE
62.79
37%
-17
- C2 -
-
5H5K
4
?
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
22
PsiBlast_CBE
62.78
51%
-48
- C2 -
-
4GMD
1
KTHY_PSEAE
C:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
G
K
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
------------
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
30
PsiBlast_CBE
62.75
49%
-35
- C2 -
-
4E5U
1
KTHY_PSEAE
B:
[7-189]
--
L
F
V
T
L
E
G
P
E
G
A
--
S
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
D
--
E
P
M
-
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
-
A
A
A
R
G
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
51
PsiBlast_CBE
62.65
37%
-19
- C2 -
-
2CCG
1
KTHY_STAAM
B:
[24-218]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
---------
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
T
I
--------
58
PsiBlast_CBE
62.59
37%
-13
- C2 -
-
5XB2
2
?
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
68
PsiBlast_CBE
62.54
37%
-13
- C2 -
-
4S35
3
KTHY_AQUAE
B:
[1-190]
--
M
L
I
A
F
E
G
I
D
G
S
G
K
T
T
Q
A
K
----
K
L
Y
E
Y
L
K
Q
K
----
G
-
Y
F
V
S
L
Y
R
-
E
P
G
G
T
K
V
G
E
V
L
R
E
I
L
L
T
------
E
E
L
D
E
R
T
E
L
L
L
F
E
A
S
R
S
K
L
I
E
E
K
I
I
P
D
L
K
R
D
K
V
V
I
L
D
R
F
V
L
S
T
I
A
Y
Q
G
Y
G
K
G
L
D
V
E
F
I
K
N
L
N
E
-
F
A
--
T
R
GV
K
----
P
D
I
T
L
L
L
D
I
P
V
D
I
A
L
R
R
-
L
K
E
K
------
N
R
-
F
E
N
K
E
--
F
L
E
K
V
R
K
G
F
L
E
L
A
K
-
E
E
E
N
V
V
V
I
D
A
S
G
E
E
E
E
V
F
K
E
I
L
R
A
L
S
-------
8
PsiBlast_PDB
62.47
41%
24
- C2 -
-
4TMK
1
KTHY_ECOLI
A:
[5-198]
---
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
A
R
N
----
V
V
V
E
T
L
E
Q
L
----
G
I
R
D
M
V
F
T
R
-
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
I
K
S
VG
D
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
G
I
D
Q
H
M
L
A
T
L
R
D
A
V
L
--
G
D
--
F
R---
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
-
A
R
A
R
G
E
L
---
D
R
-
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
-
A
A
Q
D
K
S
I
H
T
I
D
A
T
Q
P
L
E
A
V
M
D
--------------
12
PsiBlast_PDB
62.31
38%
-20
- C2 -
-
2CCJ
2
KTHY_STAAM
A:
[4-196]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
------
N
R
-
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
----
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
112
HHSearch
62.05
38%
-30
* C2 *
-
3HJN
2
KTHY_THEMA
A:
[1-189]
--
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
Q
I
Q
----
L
L
A
Q
Y
L
E
K
R
----
G
-
K
K
V
I
L
K
R
-
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
E
E
------
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
-
L
L
V
T
E
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
N
L
G
K
E
I
V
E
E
L
N
D
F
A
T
D
-
G
L
--
I
----
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
-
K
---
N
R
F
---
E
----
K
R
--
E
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
H
R
D
V
V
R
E
V
--------
48
PsiBlast_CBE
62.03
38%
-16
- C2 -
-
4HLC
1
KTHY_STAAR
B:
[4-196]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
45
PsiBlast_CBE
61.77
38%
-17
- C2 -
-
4QGA
1
KTHY_STAAR
B:
[4-196]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
S
----------
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
75
PsiBlast_CBE
61.61
39%
7
- C2 -
-
3V9P
4
KTHY_BURTA
A:
[27-225]
---
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
W
F
C
D
R
L
Q
E
R
L
G
P
A
----
G
-
R
H
V
V
V
T
R
-
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
------
N
Q
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
--
G
G
--
F
Q---
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
----
R
G
A
V
RMP----
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
K
Q
L
E
G
V
L
A
-------
50
PsiBlast_CBE
61.45
38%
-15
- C2 -
-
2CCJ
4
KTHY_STAAM
B:
[4-196]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
G
N
-----
D
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
-------
N
R
-
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
----
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
11
PsiBlast_PDB
61.26
38%
-16
- C2 -
-
4EAQ
1
KTHY_STAAM
A:
[28-220]
---
F
I
T
F
E
G
P
E
G
S
G
K
T
T
V
I
N
----
E
V
Y
-
H
R
L
V
K
----
D
-
Y
D
V
I
M
T
R
-
E
P
G
G
V
P
T
G
E
E
I
R
K
I
V
L
E
--------
M
D
I
R
T
E
A
M
L
F
A
A
S
R
R
E
H
L
V
L
K
V
I
P
A
L
K
E
G
K
V
V
L
C
D
R
Y
I
D
S
S
L
A
Y
Q
G
Y
A
R
G
I
G
V
E
E
V
R
A
L
N
E
F
A
I
--
N
G
--
L
Y---
P
D
L
T
I
Y
L
N
V
S
A
E
V
G
R
E
R
I
I
K
N
--------
R
-
L
D
Q
E
D
L
K
F
H
E
K
V
I
E
G
Y
Q
E
I
I
H
N
E
S
Q
R
F
K
S
V
N
A
D
Q
P
L
E
N
V
V
E
D
T
Y
Q
----------
105
HHSearch
61.22
41%
14
- C2 -
-
3V9P
4
KTHY_BURTA
A:
[26-224]
--
K
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
----
W
F
C
D
R
L
Q
E
R
L
G
P
A
G
-
R
H
V
V
V
T
R
-
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
N
Q
------
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
G-
G
F
--
Q
----
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
-
R
G
A
V
R
M
P
-------
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
K
Q
L
E
G
V
L
--------
4
PsiBlast_PDB
60.78
51%
-39
- C2 -
-
3UXM
1
KTHY_PSEAE
A:
[3-185]
--
L
F
V
T
L
E
G
P
E
G
----
T
N
R
D
----
Y
L
A
E
R
L
R
E
R
----
G
-
I
E
V
Q
L
T
R
-
E
P
G
G
T
P
L
A
E
R
I
R
E
L
L
L
A
P
S
---
D
E
P
M
A
A
D
T
E
L
L
L
M
F
A
A
R
A
Q
H
L
A
G
V
I
R
P
A
L
A
R
G
A
V
V
L
C
D
R
F
T
D
A
T
Y
A
Y
Q
G
G
G
R
G
L
P
E
A
R
I
A
A
L
-
E
S
F
V
QG
D
L
--
R
----
P
D
L
T
L
V
F
D
L
P
V
E
I
G
L
A
R
------
R
L
---
D
R
-
F
E
Q
E
D
R
R
F
F
E
A
V
R
Q
T
Y
L
Q
R
A
A
Q
A
P
E
R
Y
Q
V
L
D
A
-----------------------
9
PsiBlast_PDB
60.66
41%
21
- C2 -
-
5TMP
1
KTHY_ECOLI
A:
[5-198]
---
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
A
R
N
----
V
V
V
E
T
L
E
Q
L
----
G
I
R
D
M
V
F
T
R
-
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
I
K
S
VG
D
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
G
I
D
Q
H
M
L
A
T
L
R
D
A
V
L
--
G
D
--
F
R---
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
-
A
R
A
R
G
E
L
---
D
R
-
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
-
A
A
Q
D
K
S
I
H
T
I
D
A
T
Q
P
L
E
A
V
M
D
--------------
114
HHSearch
60.49
39%
27
- C2 -
-
3N2I
1
KTHY_VIBCH
B:
[28-226]
--
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
A
I
Q
----
V
V
V
E
T
L
Q
Q
N
----
G
-
I
D
H
I
T
R
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
E
H
P
--
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G-
D
F
--
K
----
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
-
A
R
G
R
G
E
L
---
D
R
-
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
T
A
D
I
R
R
A
L
--------
106
HHSearch
60.20
41%
17
- C2 -
-
3V9P
3
KTHY_BURTA
B:
[26-224]
--
K
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
----
W
F
C
D
R
L
Q
E
R
L
G
PA
G
-
R
H
V
V
V
T
R
-
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
N
Q
------
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
G-
G
F
--
Q
----
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
-
R
G
A
V
R
M
P
---
D
K
-
F
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
K
Q
L
E
G
V
L
--------
90
Fugue
59.89
40%
29
- C2 -
-
4TMK
1
KTHY_ECOLI
A:
[2-211]
R
S
K
Y
I
V
I
E
G
L
E
G
A
G
K
T
T
A
R
N
----
V
V
V
E
T
L
E
Q
L
----
G
I
R
D
M
V
F
T
R
-
E
P
G
G
T
Q
L
A
E
K
L
R
S
L
L
L
D
I
K
S
VG
D
E
V
I
T
D
K
A
E
V
L
M
F
Y
A
A
R
V
Q
L
V
E
T
V
I
K
P
A
L
A
N
G
T
W
V
I
G
D
R
H
D
L
S
T
Q
A
Y
Q
G
G
G
R
G
---
I
D
Q
H
M
L
A
T
L
R
D
--
A
V
--
L
GDFR
P
D
L
T
L
Y
L
D
V
T
P
E
V
G
L
K
R
-
A
R
A
R
G
E
L
---
D
R
-
I
E
Q
E
S
F
D
F
F
N
R
T
R
A
R
Y
L
E
L
A
A
Q
D
-
K
S
I
H
T
I
D
A
T
-
Q
P
L
E
A
V
M
D
A
I
R
T
T
V
T
H
W
V
K
E
L
54
PsiBlast_CBE
59.73
40%
28
- C2 -
-
3N2I
1
KTHY_VIBCH
A:
[29-218]
---
F
I
V
I
E
G
L
E
G
A
G
K
S
T
A
I
Q
----
V
V
V
E
T
L
Q
Q
N
----
G
I
D
H
I
T
R
T
R
-
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
E
H
P
--
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
--
G
D
--
F
K---
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
-
A
R
G
--
E
L
---
D
R
-
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
----------------
53
PsiBlast_CBE
59.55
40%
29
- C2 -
-
3N2I
1
KTHY_VIBCH
B:
[29-218]
---
F
I
V
I
E
G
L
E
G
A
G
K
S
T
A
I
Q
----
V
V
V
E
T
L
Q
Q
N
----
G
I
D
H
I
T
R
T
R
-
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
E
H
P
--
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
--
G
D
--
F
K---
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
-
A
R
G
R
G
E
L
---
D
R
-
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
----------------
74
PsiBlast_CBE
59.53
39%
14
- C2 -
-
3V9P
3
KTHY_BURTA
B:
[27-225]
---
F
I
T
F
E
G
I
D
---
K
T
T
H
L
Q
W
F
C
D
R
L
Q
E
R
L
G
P
A
----
G
-
R
H
V
V
V
T
R
-
E
P
G
G
T
R
L
G
E
T
L
R
E
I
L
L
------
N
Q
P
M
D
L
E
T
E
A
L
L
M
F
A
G
R
R
E
H
L
A
L
V
I
E
P
A
L
A
R
G
D
W
V
V
S
D
R
F
T
D
A
T
F
A
Y
Q
G
G
G
R
G
L
P
R
D
K
L
E
A
L
E
R
W
V
Q
--
G
G
--
F
Q---
P
D
L
T
V
L
F
D
V
P
P
Q
I
A
S
A
R
----
R
G
A
V
RMP
D
K
-
F
E
S
E
S
D
A
F
F
A
R
T
R
A
E
Y
L
R
R
A
Q
E
A
P
H
R
F
V
I
V
D
S
S
E
P
I
A
Q
I
R
K
Q
L
E
G
V
L
A
-------
113
HHSearch
59.24
39%
22
- C2 -
-
3LV8
2
KTHY_VIBCH
A:
[28-226]
--
K
F
I
V
I
E
G
L
E
G
A
G
K
S
T
A
I
Q
----
V
V
V
E
T
L
Q
Q
N
----
G
-
I
D
H
I
T
R
T
R
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
E
H
P
--
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
G-
D
F
--
K
----
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
------
E
L
---
D
R
-
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
T
A
D
I
R
R
A
L
--------
77
PsiBlast_CBE
58.55
40%
-11
- C2 -
-
3HJN
2
KTHY_THEMA
A:
[1-181]
--
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
Q
I
Q
----
L
L
A
Q
Y
L
E
K
R
----
G
-
K
K
V
I
L
K
R
-
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
------
E
E
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
L
L
V
T
E
-
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
N
L
G
K
E
I
V
E
E
L
N
-
D
F
A
--
T
D
GL
I
----
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
----
K
------
N
R
-
F
--
E
K
R
E
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
----------------
55
PsiBlast_CBE
57.94
40%
25
- C2 -
-
3LV8
2
KTHY_VIBCH
A:
[29-218]
---
F
I
V
I
E
G
L
E
G
A
G
K
S
T
A
I
Q
----
V
V
V
E
T
L
Q
Q
N
----
G
I
D
H
I
T
R
T
R
-
E
P
G
G
T
L
L
A
E
K
L
R
A
L
V
K
E
E
H
P
--
G
E
E
L
Q
D
I
T
E
L
L
L
V
Y
A
A
R
V
Q
L
V
E
N
V
I
K
P
A
L
A
R
G
E
W
V
V
G
D
R
H
D
M
S
S
Q
A
Y
Q
G
G
G
R
Q
I
A
P
S
T
M
Q
S
L
K
Q
T
A
L
--
G
D
--
F
K---
P
D
L
T
L
Y
L
D
I
D
P
K
L
G
L
E
R
------
E
L
---
D
R
-
I
E
K
M
D
I
S
F
F
E
R
A
R
E
R
Y
L
E
L
A
N
S
D
-
D
S
V
V
M
I
D
A
A
Q
S
I
E
Q
V
----------------
76
PsiBlast_CBE
56.01
40%
-14
- C2 -
-
3HJN
2
KTHY_THEMA
B:
[1-181]
--
M
F
I
T
F
E
G
I
D
G
S
G
K
S
T
Q
I
Q
----
L
L
A
Q
Y
L
E
K
R
----
G
-
K
K
V
I
L
K
R
-
E
P
G
G
T
E
T
G
E
K
I
R
K
I
L
L
------
E
E
E
V
T
P
K
A
E
L
F
L
F
L
A
S
R
N
L
L
V
T
E
-
I
K
Q
Y
L
S
E
G
Y
A
V
L
L
D
R
Y
T
D
S
S
V
A
Y
Q
G
F
G
R
N
L
G
K
E
I
V
E
E
L
N
-
D
F
A
--
T
D
GL
I
----
P
D
L
T
F
Y
I
D
V
D
V
E
T
A
L
K
R
-----------
N
R
-
F
--
E
K
R
E
F
L
E
R
V
R
E
G
Y
L
V
L
A
R
E
H
P
E
R
I
V
V
L
D
G
K
R
S
I
E
E
I
----------------