@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1161: (2016-03-22 )
MDILQTANERMEQLAALMNKDIEQKIPAGEKVKVGVDLGTSSIVFVVLDENNVPLFGAFEFADAVRDGLVVNYRESVEVVTRLKNRAEKCLGISLTHASGAIPPGTVGNNKKVVANVIESAGMEALYTIDEPTAAAAVLDLQNGAVVDVGGGTTGISVFENGEVIYTADEPTGGTHMTLVLAGYYGVPVEEAEQNKRAQKDSSEHFSVMRPVVEKMAEITRVHLEKSPSEPLYIVGGASAYSQFKDTFESYLKMPVFQPNYPQYVTPLGIAMSSGSENL
Atome Classification :
(20 SA)
--------------------------------------------------------------------.........10.....-..-.20........----30-----------........40........-50---..---------------.----.--..------.----------------..--------60-------.-----........70........80......-..90........100--------------------------.-.-...-----------..------------------------------------------------------------------------------.-------.-----110--.....-.-..120----------.--------------........130......-.140------.------------...------------.....150--.......160.--...--.--.-----.---..170---.-------------------......180.----...---------.------.-------------------.-------------------190..-----------.------------------...--------.200---------------------------------.------------------------------.--------------------------.---------------------------------------..----.-------------------...-----210------.......----220....-.-------..--230.----......240..-.....250-.-.---.---------.--------------------.--------------------.--------------------.260.......270.......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------M
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KIPAG----
E
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-----------
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LGT
S
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I
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D-E----NN---------------
V
----
P
--
L
F
------
G
----------------
A
F
--------
E
--------
F
-----
A
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A
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RD
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Y
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K
N
R
A
-
E
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C
L
G
I
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LTHASG----------------------------A-I-PPG-----------TV------------------------------------------------------------------------------G-------N-----
N
K
---
K
V
V
A
N
-
V
-
I
E
S
------------A--------------GM
E
A
L
Y
TIDEPTA
A
A
A
V
-
L
D--------L------------QN
G
------------
A
V
V
DVGGG--TT
G
I
S
V
F
E--N--G
E
V
--
I
--
Y
-----T---ADEPT---G-------------------G
T
H
M
T
L
V
L
AG----YYG---------V------P-------------------
V
-------------------
E
E
A
E
Q
-----------
N
------------------
K
RA--------QK-----------------------------------D------------------------------
S
--------------------------
S
---------------------------------------
E
H
----
F
-------------------
S
V
M
-----
R
P
V
------
V
E
K
M
A
E
I
----
T
R
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LEK-S-------PS--E
P
L
Y
----
I
VGG
A
S
A
Y
S
Q
F
-
K
D
T
F
E
S
Y
L-K-M---P---------V--------------------F--------------------Q--------------------PNYP
Q
Y
V
T
P
L
G
I
A
MSSGSENL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
89.02
18%
-69
- C1 -
2YCH
3
?
A:
[11-374]
--------------------------------------------------------------------------------------------------
P
----
R
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-----------
E
A
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L
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----
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----
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A
------
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----------------
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--------
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--------
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-----
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----
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----------------------------
A
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-----------
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KMP
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E
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ERYIPFPIE
V
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LTPLSEVQEG
E
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-----
A
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---
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------------
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-
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----
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---------
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------
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-------------------
L
A
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-----------
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------------------
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--------
Y
----------------------------------------------------------------------------------------------
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---------------------------------------
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----
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-------------------
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------
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----
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-
F
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L---
S
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--
E
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Y
----
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R
G
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-
A
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D
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-
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-
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---
N
---------
L
--------------------
E
--------------------
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V
N
PWEA
V
A
V
D
PKRFE
S
E
Q
L
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E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
87.05
26%
-60
- C1 -
2V7Y
2
DNAK_GEOKA
A:
[88-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
S
A
I
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Y
L
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Y
A
-
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I
----------------------------
T
-
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-
P
A
Y
-----------
F
N
------------------------------------------------------------------------------
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-------
A
-----
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---
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-
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-
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DKE
E
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-------
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------------
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--
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--
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--
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--
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---
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---
G
-------------------
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D
Q
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D
----
Y
L
V
---------
N
------
Q
F
K
Q
E
HGIDLSKD
K
M
A
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R
L
K
-------------------
D
A
A
E
K
-----------
A
------------------
K
K
E
--------
L
S
-----------------------------------
G
VTQTQISLPFISANEN
G
P
L
H
L
E
M
T
L
T
----
R
--------------------------
A
---------------------------------------
K
F
----
E
-------------------
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-----
A
H
L
------
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P
----
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-
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GLTPA--
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--
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----
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-
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-
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---
E
---------
P
--------------------
H
--------------------
K
--------------------
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
83.34
24%
-61
- C1 -
3QFU
3
GRP78_YEAST
A:
[134-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
M
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L
G
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M
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-
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K
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H
A
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----------------------------
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-
P
A
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-----------
F
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------------------------------------------------------------------------------
D
-------
A
-----
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---
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-
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-
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------------
A
--------------
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-
Y
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--------
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DKSD
K
E
------
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------------
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--
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--
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EVQ
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---
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-------------------
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E
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D
Y
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R
----
Q
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I
---------
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------
A
-------------------
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
A
E
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-----------
A
------------------
K
R
A
--------
L
S
-----------------------------------
S
------------------------------
Q
M
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E
I
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SFVDG
I
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E
T
L
T
R
----
A
---------------------------------------
K
F
----
E
-------------------
E
L
N
-----
L
D
L
------
F
K
K
T
L
K
P
----
V
E
K
V
L
Q
D
-
S
GLEKK--
D
V
--
D
D
I
V
----
L
V
G
G
S
T
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K
V
-
Q
Q
L
L
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F
-
D
G
K
---
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---------
A
--------------------
S
--------------------
K
--------------------
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I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.21
16%
-68
- C1 -
3WQT
4
FTSA_STAAR
A:
[20-388]
--------------------------------------------------------------------------------------------------------
H
-----------
Y
Y
V
S
I
D
I
G
S
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S
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E
-
K
----
F
H
N
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I
------------
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----
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--
I
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------
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----------------
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--------
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--------
Y
-----
T
S
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N
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A
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-
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L
----------------------------
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-
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-
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YEDTEIN
G
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EQETEVI
N
V
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DKENEVSDPKELIAR
H
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A
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V
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A
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Q----
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---
I
N
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-
C
-
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E
A
------------
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S
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Y
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-
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K
E
--------
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G
A
------------
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V
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I
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A
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Y
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R
D
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A
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N
---------
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------
S
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Y
-------------------
E
T
A
E
K
-----------
V
------------------
K
H
Q
--------
Y
G
-----------------------------------
H
------------------------------
A
FYDSASDQD
I
F
T
V
E
Q
VDSD
E
T
V
Q
Y
T
Q
K
---------------------------------------
D
L
----
S
-------------------
D
F
I
-----
E
A
R
------
V
E
E
I
F
F
E
----
V
F
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V
L
Q
D
-
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GLTK---
V
N
--
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F
I
----
V
T
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G
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A
N
L
L
G
V
-
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L
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M
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-
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-
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---
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V
--------------------
R
--------------------
I
H
T
P
SQMG-------------
I
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
81.54
18%
-59
- C1 -
3D2F
3
?
A:
[117-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
A
A
M
F
I
D
K
V
K
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-
K
Q
D
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C
I
----------------------------
A
-
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-
P
P
W
-----------
Y
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------------------------------------------------------------------------------
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---
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N
I
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-
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--------
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KTDLPEGEEK
P
R
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----
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F
A
---------
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YKIDIREN
P
K
A
Y
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-----------
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K
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--------
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-----------------------------------
A
N
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A
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SVMND
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------
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KLSAE--
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--
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L
N
Q
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E
A
I
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K
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A
A
F
I
C
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
80.94
21%
-63
- C1 -
3I33
3
HSP72_HUMAN
A:
[141-400]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
T
K
M
K
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I
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------------------------------------------------------------------------------
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--------
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DKKGCAGGE---
K
N
V
------------
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--
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HKKDIGPN
K
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R
R
L
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T
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E
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-----------
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R
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ST
Q
A
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SLYEG
V
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--------
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---------------------------------------
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-----
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K
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-
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KLDKG--
Q
I
--
Q
E
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L
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G
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S
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P
K
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-
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G
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---
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S
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A
V
A
Y
G
A
A
V
Q
A
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
77.79
16%
-69
* C1 *
3WT0
1
FTSA_STAAW
A:
[20-390]
--------------------------------------------------------------------------------------------------
E
----
E
H
-----------
Y
Y
V
S
I
D
I
G
S
S
S
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K
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I
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G
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----
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H
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------------
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----
V
--
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Q
--------
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Y
-----
T
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A
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K
A
-
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----------------------------
K
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D
T
E
I
N
G
S
H
I
E
K
V
L
E
G
I
R
E
K
NDVQETEVI
N
V
F
P
I
R
F
I
V
DKENEVSDPKELIAR
H
S
L
K
V
E
A
G
V
I
A
I
Q
K
-------
S
-----
I
L
---
I
N
M
I
K
-
C
-
V
E
A
------------
C
--------------
G
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
-
L
T
--------
A
T
E
K
E
--------
L
G
A
------------
C
V
I
D
I
G
E
D
--
V
T
Q
V
A
F
Y
E
--
R
--
G
E
L
--
V
--
D
-----
A
---
D
S
I
E
M
---
A
-------------------
G
R
D
I
T
D
D
I
A
Q
----
G
L
N
---------
T
------
S
-------------------
Y
-------------------
E
T
A
E
K
-----------
V
------------------
K
H
Q
--------
Y
G
-----------------------------------
H
AFYDSASDQ
D
I
F
T
V
E
Q
VDSD
E
T
V
Q
Y
T
----
Q
--------------------------
K
---------------------------------------
D
L
----
S
-------------------
D
F
I
-----
E
A
R
------
V
E
E
I
F
F
E
----
V
F
D
V
L
Q
D
-
L
GLTK---
V
N
--
G
G
F
I
----
V
T
G
G
S
A
N
L
L
G
V
-
K
E
L
L
S
D
M
V
-
S
-
E
---
K
---------
V
--------------------
R
--------------------
I
H
T
P
SQMG-------------
I
R
K
P
E
F
S
S
A
I
S
T
I
S
S
S
I
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
75.37
15%
-62
- C1 -
1HUX
2
HGDC_ACIFV
A:
[2-260]
-------------------------------------------------------------------------------------------------------
S
I
-----------
Y
T
L
G
I
D
V
G
S
T
A
S
K
C
I
I
L
K
-
D
----
G
K
---------------
E
----
I
--
V
A
------
K
----------------
S
L
--------
V
--------
A
-----
V
G
---
T
G
T
S
G
P
A
R
S
I
S
E
V
L
E
N
A
H
M
K
K
-
E
D
M
A
F
T
L
A
T
----------------------------------------------------------------------------------------------------------------------------------
G
-------
Y
-----
G
R
---
N
S
L
E
G
-
I
-
A
D
------------------------------
K
Q
M
S
E
L
S
C
H
A
M
G
A
S
F
-
I
W
--------
P
------------
N
V
H
------------
T
V
I
D
I
G
G
Q
--
D
V
K
V
I
H
V
E
--
N
--
G
T
M
--
T
--
N
-----
F
---
Q
M
N
D
K
CAA
G
-------------------
T
G
R
F
L
D
V
M
A
N
----
I
L
E
---------
V
------
K
-------------------
V
-------------------
S
D
L
A
E
-----------
L
G
A
K
ST
K
R
V
A
ISSTC
T
---
V
F
A
--------
E
S
-----------------------------------
E
------------------------------
V
--------------------------
I
---------------------------------------
S
Q
----
L
S
K
GTD
K
I
------------
D
I
I
-----
A
G
I
------
H
R
S
V
A
S
R
----
V
I
G
L
A
N
R
V
G
-------
I
V
--
K
D
V
V
----
M
T
G
G
V
A
Q
N
Y
G
V
-
R
G
A
L
E
E
G
L
-
G
-
V
---
E
---------
I
--------------------
K
--------------------
T
--------------------
S
P
L
A
Q
Y
N
G
A
L
G
A
A
L
Y
A
Y
K
K
A
A
K----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
74.59
13%
-59
- C1 -
2YCH
3
?
A:
[11-375]
--------------------------------------------PRVE
A
L
G
L
E
IGAS
A
L
K
L
V
E
V
S
G
NP
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
M
E
G
M
V
A
E
P
A
A
L
A
Q
E
I
----
K
E
-----------
L
L
L
E
A
R
T
R
K
R
Y
V
V
T
A
L
S
N
-
L
A
V
I
L
R
P
---------------
I
----
Q
--
V
P
------
K
M---------------
P
L
--------
K
--------
E
M
----
E
E
A
V
R
W
E
A
E
R
Y
I
P
F
P
I
E
V
V
L
D
F
A
P
L
T
-
P
L
S
E
--
V
Q
E
G
E
Q
V
----------------------------
Q
-
V
M
V
A
A
-----------
A
R
------------------------------------------------------------------------------
Q
-------
E
-----
A
V
---
A
G
V
L
E
-
A
-
L
R
G
------------
A
--------------
G
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
-
L
E
--------
A
------------
R
L
A
E
E
P
D
R
V
F
-----
L
V
L
D
I
G
A
E
--
S
T
S
L
V
L
L
R
--
G
--
D
K
P
--
L
--
A
-----
V
---
R
V
L
T
L
---
S
-------------------
G
K
D
F
T
E
A
I
A
R
----
S
F
N
---------
L
------
D
-------------------
L
-------------------
L
A
A
E
E
-----------
V
------------------
K
R
T
--------
Y
G
-----------------------------------
R
------------------------------
I
--------------------------
Y
---------------------------------------
D
A
----
I
R
------------------
P
V
L
-----
V
E
L
------
T
Q
E
L
R
R
S
----
L
E
F
F
R
I
Q
-
L
-------
S
P
--
E
V
G
Y
----
L
L
G
G
G
S
K
L
R
G
L
-
A
S
L
L
T
D
T
L
-
G
-
V
---
N
---------
L
--------------------
E
P
V
N
PWEA
V
A
V
D
PKRFE
S
E
Q
L
Q
--------------------
E
I
G
P
E
F
A
V
A
L
G
L
A
L
R
G
V
E
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
73.74
14%
-71
- C1 -
1HUX
2
HGDC_ACIFV
A:
[2-257]
-------------------------------------------------------------------------------------------------------
S
I
-----------
Y
T
L
G
I
D
V
G
S
T
A
S
K
C
I
I
L
K
-
D
----
G
K
---------------
E
----
I
--
V
A
------
K
----------------
S
L
--------
V
--------
A
-----
V
-
G
T
G
T
------
S
G
P
A
R
S
I
S
E
V
L
E
N
A
-
H
M
K
-
K
E
D
M
A
F
T
L
A
----------------------------
T
-
G
-
Y
G
R
-----------
N
S
---------------------------------------------------------------------------------------------------------
L
E
----------------------------
G
I
-
A
D
K
Q
M
S
E
L
S
C
H
A
M
G
-
A
S
--------
F
I
WP---------
N
V
H
------------
T
V
I
D
I
G
G
Q
--
D
V
K
V
I
H
V
E
--
N
--
G
T
M
--
T
--
N
-----
F
Q
M
N
D
K
C
A
A
---
G
-------------------
T
G
R
F
L
D
V
M
A
N
----
I
L
E
---------
V
------
K
-------------------
V
-------------------
S
D
L
A
E
-----------
L
G
A
K
S--------------
T
K
R
--------
V
A
ISSTC
T
V
F
A
E
S
E
V
I
S
Q
L
S
-----------------
K
------------------------------
G
--------------------------
T
---------------------------------------
D
K
----
I
-------------------
D
I
I
-----
A
G
I
------
H
R
S
V
A
S
R
----
V
I
G
L
A
N
R
-
V
G------
I
V
--
K
D
V
V
----
M
T
G
G
V
A
Q
N
Y
G
V
-
R
G
A
L
E
E
G
L
-
G
-
V
---
E
---------
I
--------------------
K
--------------------
T
--------------------
S
P
L
A
Q
Y
N
G
A
L
G
A
A
L
Y
A
Y
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
70.41
18%
-51
- C1 -
1K8K
-
ARP3_BOVIN
A:
[3-388]
--------------------------------------------------------------------------------------------------
G
----
R
L
-----------
P
A
C
V
V
D
C
G
T
G
Y
T
K
L
G
Y
A
G
-
N
----
T
E
---------------
P
Q
F
I
I
P
--
S
C
------
I
A
I
K
EVMKGVDDLDFFI
G
D
EAIEKPT
Y
A
--------
T
-----
K
W
P
I
R
H
G
I
V
E
D
W
D
L
M
E
R
F
M
E
Q
V
I
F
K
Y
-
L
R
-
A
E
P
E
D
H
Y
F
L
L
----------------------------
T
-
E
-
P
P
L
-----------
N
T
------------------------------------------------------------------------------
P
-------
E
-----
N
R
---
E
Y
T
A
E
-
I
M
F
E
S
------------
F
--------------
N
V
P
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
-
S
W
TSRQVGER
T
------------
L
T
G
------------
T
V
I
D
S
G
D
G
--
V
T
H
V
I
P
V
A
--
E
--
G
Y
V
--
I
--
G
-----
S
C
I
-
K
H
I
P
I
---
A
-------------------
G
R
D
I
T
Y
F
I
Q
Q
----
L
L
R
D
REVGIPPE
Q
------
S
-------------------
L
-------------------
E
T
A
K
A
-----------
V
------------------
K
E
R
--------
Y
S
-----------------------------------
Y
------------------------------
V
--------------------------
C
PD
L
V
K
E
F
N
K
Y
D
T
DGSKW
I
K
Q
Y
T
G
I
N
AISK
K
E
F
S
I
D
V
G
YE
R
F
LGP-
E
-------------------
I
F
F
-----
H
P
E
FANPDF
T
Q
P
I
S
E
V
----
V
D
E
V
I
Q
N
-
C
PIDV
R
R
P
L
Y
--
K
N
I
V
----
L
S
G
G
S
T
M
F
R
D
F
-
G
R
R
L
Q
R
D
L
-
K
-
R
---
T
---------
V
D
A
R
L
K
L
S
E
E
L
SKPK
P
I
D
V
Q
V
I
--------------------
T
--------------------
H
H
M
Q
R
Y
A
V
W
F
G
G
S
M
L
A
S
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
68.54
16%
-44
- C1 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
T
P
F
G
L
DLGNN
N
S
V
L
A
V
A
R
NR
G
I
D
I
V
V
N
EVSNRSTPS
V
V
G
F
G
PK
N
R
Y
L
G
E
T
G
K
N
K
Q
TSNIKNTVANLKR
I
I
G
L
D
Y
H
H
P
D
F
E
Q
E
S
K
-
H
F
-
T
S
K
L
V
E
--
L
D
D
----
K
K
-----------
T
G
A
E
V
R
F
A
G
E
K
H
V
F
S
----------------------------------------------------------------------------------------------
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
-
K
Q
D
T
K
A
N
I
T
D
V
C
I
----------------------------
A
-
V
-
P
P
W
-----------
Y
T
------------------------------------------------------------------------------
E
-------
E
-----
Q
R
---
Y
N
I
A
D
-
A
-
A
R
I
------------
A
--------------
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
-
Y
G
--------
I
------------
F
K
T
DLPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
--
K
--
G
Q
L
--
K
--
V
-----
L
---
G
T
A
C
D
KHF
G
-------------------
G
R
D
F
D
L
A
I
T
E
----
H
F
A
---------
D
------
E
-------------------
F
-------------------
K
T
K
-------------
Y
------------------
K
I
D
--------
I
R
-----------------------------------
E
------------------------------
N
--------------------------
P
---------------------------------------
K
A
----
Y
-------------------
N
R
I
-----
L
T
A
------
A
E
K
L
K
K
V
L
S
A
N
T
N
A
P
F
S
V
-
E
-------
S
-----------
V
M
N
D
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
-----------------------------------------------------------
K
--------------------
P
L
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
EEVD
F
V
E
I
I
G
GTTRI
P
T
L
K
Q
S
I
S
E
A
F
G
K
P
L
S
TTLNQDE
A
I
A
K
G
A
A
F
I
C
A
IHSR
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
DKQVEDED
H
M
E
V
FPAGSSFP
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
TDITQLPPNTPEQI
A
N
W
E
I
TD
S
V
P
V
K
L
K
L
R
CDPSG
L
H
T
I
E
E
A
Y
T
I
E
DK
T
V
K
K
D
D
L
T
I
V
A
H
T
FGLD
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
EEYAPFAS
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
DEGFDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
58
Fugue
65.85
13%
-84
- C1 -
1Z05
8
?
A:
[34-429]
-----------------------------------D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
KGPIS
R
I
D
L
S
K
E
S
ELA
P
A
S
I
T
K
I
T
R
E
L
I
D
A
H
L
-
I
H
-
E
T
T
V
Q
E
A
I
S
R
G
----
R
P
A
V
G
L
QTNNLG
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
----
G
E
---------------
V
----
L
--
I
D
------
T
----------------
K
I
--------
D
--------
I
-----
H
E
I
D
Q
D
D
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
T
Y
A
A
Q
L
D
R
V
T
S
I
A
I
T
L
P
G
L
----------------------------
V
N
S
-
E
Q
G
-----------
I
V
------------------------------------------------------------------------------
L
QMPHYNV
K
-----
N
L
---
A
L
G
P
E
-
I
-
Y
K
A
------------
T
--------------
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
-
K
L
--------
F
GHSQDV------
D
N
S
------------
V
L
I
S
I
H
H
G
---
L
G
A
G
I
V
L
--
D
--
G
R
V
--
L
--
Q
-----
G
---
R
H
G
N
I
---
G
ELGHIQIDPQGKRCHCGNY
G
C
L
E
T
V
A
S
S
Q
----
A
I
R
---------
D
------
Q
-------------------
V
-------------------
T
A
R
I
Q
-----------
A
G
E
P
S
CLATVEEIS
I
E
D
I
C
A
A
A
--------
A
D
-----------------------------------
G
------------------------------
D
--------------------------
P
---------------------------------------
L
A
----
V
-------------------
D
V
I
-----
Q
Q
L
------
G
R
Y
L
G
A
A
----
I
A
I
V
I
N
L
-
F
-------
N
P
--
E
K
I
L
----
I
G
G
---
V
I
N
Q
A
-
K
S
I
L
Y
P
S
I
-
E
-
Q
---
C
---------
I
--------------------
R
--------------------
E
--------------------
Q
S
L
P
V
Y
H
Q
D
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
Y
D
G
L
L
L
M
K
V
V
E
G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
61.87
20%
-53
- C1 -
2FSJ
1
ACTH_THEAC
A:
[122-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
G
S
----------------------------
G
-
T
-
P
L
G
-----------
T
F
------------------------------------------------------------------------------
D
-------
L
-----
E
V
---
K
A
A
K
E
-
A
-
L
E
N
------------
K
V
L
T
V
T
G
PEG
E
V
R
Q
F
N
I
T
R
L
I
M
R
P
Q
G
V
G
A
A
L
Y
-
L
L
--------
N
Q
GI
I
E
Q
Q
P----
G
Y
G
------------
V
V
I
D
V
G
S
R
--
T
T
D
V
L
T
I
N
--
L
MD
M
E
P
VV
E
--
L
-----
S
---
F
S
L
Q
I
---
G
-------------------
V
G
D
A
I
S
A
L
S
R
----
K
I
A
---------
K
------
E
-------------------
T
GFVVP
F
-------------
D
L
A
Q
E
-----------
A
------------------
L
S
H
P
V
M
F
RQKQ
V
G
-----------------------------------
G
------------------------------
P
--------------------------
E
---------------------------------------
V
S
----
G
-------------------
P
I
L
-----
E
D
L
------
A
N
R
I
I
E
N
----
I
R
L
N
L
R
G
-
E
VD-----
R
V
--
T
S
L
I
----
P
V
G
G
G
S
N
L
--
I
-
G
D
R
F
E
E
I
A
-
P
-
G
T--
L
---------
V
--------------------
K
--------------------
I
K-------------------
P
E
D
L
Q
F
A
N
A
L
G
Y
R
D
A
A
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
61.85
19%
-45
- C1 -
3DWL
1
ARP3_SCHPO
A:
[92-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
I
R
H
G
Q
I
E
N
W
D
H
M
E
R
F
W
Q
Q
S
L
F
K
Y
-
L
R
-
C
E
P
E
D
H
Y
F
L
L
----------------------------
T
-
E
-
P
P
L
-----------
N
P
------------------------------------------------------------------------------
P
-------
E
-----
N
R
---
E
N
T
A
E
I
M
-
F
E
S
------------
F
--------------
N
C
A
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
-
S
W
T
SSKVTDR
S
------------
L
T
G
------------
T
V
V
D
S
G
D
G
--
V
T
H
I
I
P
V
A
--
E
--
G
Y
V
--
I
--
G
-----
S
SI-
K
T
M
P
L
---
A
-------------------
G
R
D
V
T
Y
F
V
Q
S
----
L
L
R
------------------------------------
L
-------------------
K
T
A
E
R
-----------
I
------------------
K
E
E
--------
C
C
-----------------------------------
Y
------------------------------
V
C
PD
I
V
K
E
F
S
R
F
DRLKYASIDVG----
F
---------------------------------------
E
R
FLAP
E
-------------------
I
F
F
-----
N
P
E
IASSDF
L
T
P
L
P
E
L
----
V
D
N
V
V
Q
S
-
S
PIDV
R
K
G
L
Y
--
K
N
I
V
----
L
S
G
G
S
T
L
F
K
N
F
-
G
N
R
L
Q
R
D
L
-
K
-
R
---
I
V
D
E
RG
V
D
V
N
V
--------------------
I
--------------------
S
--------------------
H
K
R
Q
R
N
A
V
W
F
G
G
S
L
L
A
Q
T
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
61.62
20%
-14
- C1 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--------------------KIIGIDLGTTNSCVAIMDGTTPRVLENAEGDRTTPSIIAYTQDGETLV
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
-
F
A
-
I
K
R
L
I
G
R
R
F
Q
D
----
E
E
-----------
V
Q
R
D
V
S
I
M
----
P
F
K
I
I
A
-
A
----
D
N
---------------
G
----
D
--
A
W
------
V
----------------
E
V
-----------------------
K
G
----
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
-
E
D
Y
L
G
E
P
V
T
E
A
V
I
----------------------------
T
-
V
-
P
A
Y
-----------
F
N
------------------------------------------------------------------------------
D
-------
A
-----
Q
R
---
Q
A
T
K
D
-
A
-
G
R
I
------------
A
--------------
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
-
Y
G
--------
L
DKTGN-------
R
T
I
------------
A
V
Y
D
L
G
G
G
--
T
F
D
I
S
I
I
E
--
I
--
D
E
K
--
T
--
F
-----
E
---
V
L
A
-------------------------
T
N
G
D
T
H
L
G
G
E
----
D
F
D
---------
S
------
R
-------------------
L
-------------------
I
N
Y
L
V
------------------------------
E
E
F
--------
K
K
-----------------------------------
D
------------------------------
Q
--------------------------
G
---------------------------------------
I
D
----
L
-------------------
R
N
D
-----
P
L
A
------
M
Q
R
L
K
E
A
----
A
E
K
A
K
I
E
-
L
-------
S
S
--------------------------------------------------------------------------------------------------------------
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
NIKVTRAKLESLVEDLVNRSIELLKVALQDAGLSVSDIDDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAIGAAVQGGVLT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
60.60
14%
-70
- C1 -
2D0O
2
DDRFA_KLEOK
A:
[303-605]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
I
G
G
M
L
E
H
V
R
Q
T
M
-
A
E
L
T
N
K
P
S
S
E
I
F
I
Q
D
L
L
A
V
D
T
S
V
P
V
S
V
TGGLAG
E
F
S
L
E
Q
A
V
G
-
I
-
A
S
M
-----------
V
K
------------------------------------------------------------------------------
S
-------
D
-----
R
L
Q
M
A
M
I
A
R
E
-
I
-
E
Q
K
------------
L
--------------
N
I
D
V
Q
I
G
G
A
E
A
E
A
A
I
L
G
-
A
L
--------
T
TPGTT-------
R
P
L
------------
A
I
L
D
L
G
A
G
--
S
T
D
A
S
I
I
N
--
P
--
K
G
D
--
I
--
I
-----
A
---
T
H
L
A
G
---
A
-------------------
G
D
M
V
T
M
I
I
A
R
----
E
L
G
---------
L
------
E
D------------------
R
-------------------
Y
L
A
E
E
I
K
K
Y
P
L
A
K
VES
L
------------------
F
H
L
--------
R
H
EDG
S
V
Q
F
F
STPLPPAVFARV
C
V
V
K
AD
E
L
V
P
L
PGDL
A
------------------------------
L
--------------------------
E
---------------------------------------
K
V
----
R
-------------------
A
I
R
R
S
A
K
E
R
V
F
------
V
T
N
A
L
R
A
----
L
R
Q
V
S
P
T
-
G
NIR----
D
I
--
P
F
V
V
----
L
V
G
G
S
S
L
D
F
E
V
-
P
Q
L
V
T
D
A
L
-
A
H
Y
---
R
LV
A
G
R
G
N--
I
--------------------
R
--------------------
G
--------------------
S
E
G
P
R
N
A
V
A
T
G
L
I
L
S
W
H
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
60.35
22%
-4
- C1 -
1JCE
-
?
A:
[4-327]
--------------------------------------------------------------------------------------------------------------------
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
-
K
----
G
I
V
V
N
E
P
S
V
I
A
I
DSTTG
E
----
I
--
L
K
------
V
----------------
G
L
--------
E
A
K
N
M
IGKT
P
AT
I
K
A
I
R
P
M
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
M
N
L
F
K
P
R
V
V
I
----------------------------
G
-
V
-
P
I
G
-----------
I
T
------------------------------------------------------------------------------
D
-------
V
-----
E
R
---
R
A
I
L
D
-
A
-
G
L
E
------------
A
--------------
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
-
S
N
LNVEE---
P
------------
S
G
N
------------
M
V
V
D
I
G
G
G
--
T
T
E
V
A
V
I
S
--
L
--
G
S
I
--
V
--
T
-----
W
---
E
S
I
R
I
---
A
-------------------
G
D
E
M
D
E
A
I
V
Q
----
Y
V
R
---------
E
T
YR
V
A
I
G
-------------------
E
-------------------
R
T
A
E
R
-----------
V
------------------
K
I
E
--------
I
G
-----------------------------------
N
VFPS
K
E
N
D
E
L
E
T
T
V
S
G
I
DLSTG
L
P
R
K
L
T
L
K
G
--------------------------
G
---------------------------------------
E
V
----
R
-------------------
E
A
L
-----
R
S
V
------
V
V
A
I
V
E
S
----
V
R
T
T
L
E
K
-
T
P
P
E
L
V
S
-
D
I
I
E
R
G
I
F
----
L
T
G
G
G
S
L
L
R
G
L
-
D
T
L
L
Q
K
E
T
-
G
-
I
---
S
---------
V
--------------------
I
--------------------
R
--------------------
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
56.12
15%
-54
- C1 -
2ZGY
2
PARM_ECOLX
A:
[95-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
I
V
C
----------------------------
T
-
L
-
P
L
T
-----------
E
Y
------------------------------------------------------------------------------
Y
-------
D
RNNQP
N
T
---
E
N
I
E
R
-
K
-
K
A
N
F
R
K
K
I
T
L
N
G
G
D
T
F
--------------
T
I
K
D
V
K
V
M
P
E
S
I
P
A
G
Y
E
-
V
L
--------
Q
E
LDEL-------
D
S
L
------------
L
I
I
D
L
G
G
T
--
T
L
D
I
S
Q
V
M
--
G
--
K
L
S
--
G
--
I
S
K
I
--
Y
---
G
D
S
S
L
---
G
-------------------
V
S
L
V
T
S
A
V
K
D
----
A
L
S
---------
L
ARTKG-
S
-------------------
S
-------------------
Y
L
A
D
D
-----------
I
------------------
I
I
H
--------
R
K
D
N
N
Y
L
K
Q
R
INDEN----------------------
K
------------------------------
I
--------------------------
S
---------------------------------------
I
V
----
T
-------------------
E
A
M
-----
N
E
A
------
L
R
K
L
E
Q
R
----
V
L
N
T
L
N
E
-
F
S------
G
Y
--
T
H
V
M
----
V
I
G
G
G
A
E
L
--
I
-
C
D
A
V
K
K
H
T
-
Q
-
I
RDE
R
---------
F
--------------------
F
--------------------
K
--------------------
T
N
N
S
Q
Y
D
L
V
N
G
M
Y
L
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
55.85
14%
-46
- C1 -
4I6M
6
ARP9_YEAST
B:
[3-439]
-----------------------------------------------------------------------------
P
F
R
Q
D
S
I
-
L
I
-
I
Y
P
R
S
Q
T
T
L
V
Q
F
G
LN
E
E
-----------
T
F
T
V
P
E
L
E
I
P
T
Q
I
Y
R
T
T
R
-
Q
----
D
G
---------------
S
----
Y
--
T
Y
H
STNKD
N
----------------
K
A
--------
E
--------
L
-----
I
K
P
I
Q
N
G
E
I
I
D
I
S
A
F
T
Q
F
L
R
L
I
F
V
S
I
-
L
S
D
R
A
N
K
N
Q
D
A
F
E
----------------------------
A
-
E
-
L
S
N
I
P
L
L
L
I
T
H
HSW
S
Q
------------------------------------------------------------------------------
S
-------
D
-----
L
E
---
I
I
T
Q
Y
-
V
-
F
E
S
------------
L
--------------
E
I
N
N
L
I
Q
L
P
A
S
L
A
A
T
Y
S
M
I
S
--------
L
------------
Q
N
C
------------
C
I
I
D
V
G
T
H
H
-
T
D
I
I
P
I
V
D
--
Y
--
A
Q
L
--
D
--
H
-----
L
---
V
S
S
I
P
M--
G
-------------------
G
Q
S
I
N
D
S
L
K
K
L
L
PQ
W
D
D
---------
D
------
Q
-------------------
I
-------------------
E
S
L
K
K
-----------
S
PI
F
E
V
L
------------
S
K
N
--------
S
D
-----------------------------------
L
------------------------------
E
--------------------------
F
---------------------------------------
N
T
----
F
W
D
EKG
N
E
I
K
V
G
KQRFQGC
N
N
L
I
-----
K
N
I
------
S
N
R
V
G
L
T
----
L
D
N
I
D
D
I
-
N
-------
K
A
--
K
A
V
W
E
N
I
I
I
V
G
G
T
T
S
I
S
G
F
-
K
E
A
L
L
G
Q
L
-
L
-
K
---
D
---------
H
LIIEP
E
E
E
K
S
K
R
E
E
E
A
KS--
F
--------------------
V
--------------------
P
T
I
E
Y
V
Q
C
P
T
V
I
K
L
A
K
Y
P
D
Y
F
P
E
W
K
K
S
GYSEI
I
F
L
G
A
Q
I
V
S
K
Q
I
F
T
H
PKDTFYIT
R
E
K
Y
N
M
KGPAALWDVQF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------