@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu00460: (2016-06-01 )
MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELTELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGGSSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHISTPPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLESVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQVYAVRMIGEQNALD
Atome Classification :
(32 SA)
........---.10-..----.----.....20........30.....---...40..--......-50......---.-.60--.-.-.-......70....------....80-----.........90........100.......110.......120....----...130---------...---------..---------..-----140....-...150.-.----.....160.-----...-...170.......180..------..--------...190.------....----...200.......210---...--.--..-.-.220--.......----------.230.......240.......250.......260.......270.......280.......--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
I
L
EKAP---
A
K
I
-
N
L
----
S
----
L
D
V
TRKRPDG
Y
H
E
V
E
M
I
M
T
T
ID---LA
D
R
I
E
L
--
T
E
LAED-
E
V
R
VSSHN---R-FV---P-D-D-
Q
R
N
L
A
Y
Q
A
A
K
L
I
------
K
D
R
YN------VKKG
V
S
I
M
I
T
K
VIPVAAGLAGGSS
D
A
A
A
T
L
R
G
L
N
R
L
WNLNL
S
A
E
T
L
----
A
E
L
G
A
E
---------IGS---------D
V
---------
S
F
-----
C
V
YG
G
T
A
-LATGRGE-
K
----
I
K
HISTPP
H
-----
C
W
V
-
I
L
AKPTIGV
S
T
A
E
V
Y
R
A
L
------KL--------DGIEH-P------
D
V
Q
G
----
M
I
E
A
I
E
E
K
S
F
Q
K
M
C
S
----
R
L
G
--
N
--
V
L
-
E
-
S
V
T
---LDMHP
E
V
----------
A
M
I
K
N
Q
M
K
R
FGA
D
A
V
L
MSGSG
P
T
V
F
G
L
V
Q
Y
E
S
K
V
Q
R
I
Y
N
G
L
R
G
F
C
D
Q
V
Y
A
V
R
MIGEQNALD--------------
5
PsiBlast_PDB
95.37
35%
-84
- C1 -
3PYE
1
ISPE_MYCTU
A:
[9-280]
-----
R
V
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
V
D
E
V
T
V
R
N
A
D
V
L
S
L
-
E
L
-
V
G
E
G
A
---
D
-
Q
L
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
----
R
M
L
A
A
R
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
E
----
L
A
T
V
L
S
R
N
T
-----
F
H
W
-
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
E
L
D
-----
R
L
--------
R
E
V
G
D
-
P
------
P
R
L
G
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
----
L
L
G
--
N
--
E
M
-
Q
-
A
A
A
---
V
S
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
G
A
L
A
G
I
V
S
G
S
G
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
--------------------------------
7
PsiBlast_PDB
95.09
35%
-83
- C1 -
3PYG
1
ISPE_MYCTU
A:
[9-280]
-----
R
V
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
V
D
E
V
T
V
R
N
A
D
V
L
S
L
-
E
L
-
V
G
E
G
A
---
D
-
Q
L
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
----
R
M
L
A
A
R
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
E
----
L
A
T
V
L
S
R
N
T
-----
F
H
W
-
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
E
L
D
-----
R
L
--------
R
E
V
G
D
-
P
------
P
R
L
G
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
----
L
L
G
--
N
--
E
M
-
Q
-
A
A
A
---
V
S
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
G
A
L
A
G
I
V
S
G
S
G
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
--------------------------------
6
PsiBlast_PDB
94.92
35%
-83
- C1 -
3PYF
1
ISPE_MYCTU
A:
[9-280]
-----
R
V
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
V
D
E
V
T
V
R
N
A
D
V
L
S
L
-
E
L
-
V
G
E
G
A
---
D
-
Q
L
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
----
R
M
L
A
A
R
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
E
----
L
A
T
V
L
S
R
N
T
-----
F
H
W
-
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
E
L
D
-----
R
L
--------
R
E
V
G
D
-
P
------
P
R
L
G
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
----
L
L
G
--
N
--
E
M
-
Q
-
A
A
A
---
V
S
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
G
A
L
A
G
I
V
S
G
S
G
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
--------------------------------
4
PsiBlast_PDB
93.89
35%
-82
- C1 -
3PYD
1
ISPE_MYCTU
A:
[9-280]
-----
R
V
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
R
R
E
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
V
D
E
V
T
V
R
N
A
D
V
L
S
L
-
E
L
-
V
G
E
G
A
---
D
-
Q
L
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
----
R
M
L
A
A
R
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
E
----
L
A
T
V
L
S
R
N
T
-----
F
H
W
-
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
E
L
D
-----
R
L
--------
R
E
V
G
D
-
P
------
P
R
L
G
E
P
G
P
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
P
----
L
L
G
--
N
--
E
M
-
Q
-
A
A
A
---
V
S
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
G
A
L
A
G
I
V
S
G
S
G
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
--------------------------------
38
HHSearch
93.54
33%
-88
- C1 -
3PYF
1
ISPE_MYCTU
A:
[5-282]
-
S
V
T
V
R
V
P
---
G
K
V
-
N
L
Y
L
A
V
G
----
D
R
R
E
----
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
V
D
E
V
T
V
--
R
N
A
D
V
L
-
S
L
E
L
V
G
E
G
A--
D
-
Q
L
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
M
------
A
E
H
V
G
------
R
A
P
D
V
S
I
M
I
D
K
S
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
S
L
W
E
L
N
V
P
R
R
D
L
----
R
M
L
A
A
R
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
E
----
L
A
T
V
L
S
R
N
T
-----
F
H
W
-
V
L
A
F
A
D
S
G
L
L
T
S
A
V
Y
N
E
L
------
D
R
--------
L
R
E
V
G
-
D
P
P
R
L
G
-
E
P
G
P
----
V
L
A
A
L
A
A
G
D
P
D
Q
L
A
-----
P
L
L
--
G
--
N
E
M
Q
-
A
A
A
---
V
S
L
D
P
A
L
----------
A
R
A
L
R
A
G
V
E
A
G
A
L
A
G
I
V
S
G
S
G
P
T
C
A
F
L
C
T
S
A
S
S
A
I
D
V
G
A
Q
L
S
G
A
G
------------------------------
8
PsiBlast_PDB
89.57
37%
-85
- C1 -
1UEK
-
ISPE_THET8
A:
[5-242]
------
A
P
---
A
K
V
-
N
L
----
G
----
L
S
V
R
F
R
R
E
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
---
L
A
D
R
L
V
V
--
E
P
--------
V
S
S
G
L
---
H
-
F
Q
G
--
P
-
Y
-
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
E
V
D
L
F
A
L
----
A
R
---
T
---------
L
G
A
---------
D
V
---------
P
F
-----
F
L
L
G
R
G
A
-
E
A
R
G
V
G
E
-
R
----
L
K
P
L
A
L
P
P
V
-----
P
A
V
-
V
F
-
F
P
G
L
R
V
P
T
P
L
V
Y
R
A
V
------
R
P
--------
E
D
F
-
G
-
P
------
D
L
P
------
V
E
A
I
L
E
A
L
A
R
G
E
E
P
----
P
Y
W
--
N
--
S
L
-
E
-
G
P
A
---
F
R
L
F
P
E
L
----------
K
E
V
R
G
R
M
R
A
L
G
L
R
G
V
L
M
S
G
S
G
S
A
F
F
G
L
A
E
----------------------------------------------
61
Fugue
89.07
34%
-81
- C1 -
1UEK
-
ISPE_THET8
A:
[1-268]
--
M
E
R
L
A
P
---
A
K
V
-
N
L
----
G
----
L
S
V
R
F
R
R
E
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
---
L
A
D
R
L
V
V
--
E
P
V
S
S
G
-
L
H
F
Q
G
-------------
P
-
Y
-
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
E
V
---
D
L
----
F
A
L
A
R
T
---------
L
G
A
---------
D
V
---------
P
F
-----
F
L
L
G
R
G
A
-
E
A
R
G
V
G
E
-
R
----
L
K
P
L
A
L
P
P
------
V
P
A
-
V
V
F
F
P
G
L
R
V
P
T
P
L
V
Y
R
A
V
------
R
-----------
P
E
D
-
F
------
G
P
D
L
----
P
V
E
A
I
L
E
A
L
A
R
G
E
E
P
----
P
Y
W
--
N
--
S
L
-
E
-
G
P
A
---
F
R
L
F
P
E
L
----------
K
E
V
R
G
R
M
R
A
L
G
L
R
G
V
L
M
S
G
S
G
S
A
F
F
G
L
A
E
G
P
D
H
A
R
R
A
A
E
A
L
R
A
W
G
R
A
W
A
G
T
L
G
G
G
--------------------
3
PsiBlast_PDB
86.82
35%
-73
- C1 -
4EMD
2
?
A:
[21-272]
-----
R
A
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
L
R
D
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
A
D
D
V
T
V
--
R
D
A
D
V
L
-
S
I
D
V
V
G
Q
G
---
E
G
T
V
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
----
H
H
L
A
A
Q
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
Q
----
L
A
T
V
L
A
R
N
V
-----
F
H
W
-
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
E
I
------
D
R
L
R
E
N
G---
D
P
P
R
L
-
A
------
E
A
D
E
----
L
L
G
A
L
A
A
G
D
A
R
R
L
A
P
----
L
L
G
--
N
--
E
L
-
Q
-
A
A
A
---
V
S
L
N
P
E
L
----------
R
R
T
L
R
A
G
E
S
A
G
A
L
A
G
I
V
S
G
S
G
P
T
----------------------------------------------------
1
PsiBlast_PDB
86.47
35%
-72
- C1 -
4DXL
3
?
A:
[21-272]
-----
R
A
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
L
R
D
D
G
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
A
D
D
V
T
V
--
R
D
A
D
V
L
-
S
I
D
V
V
G
Q
G
---
E
G
T
V
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
----
H
H
L
A
A
Q
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
Q
----
L
A
T
V
L
A
R
N
V
-----
F
H
W
-
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
E
I
------
D
R
L
R
E
N
G---
D
P
P
R
L
-
A
------
E
A
D
E
----
L
L
G
A
L
A
A
G
D
A
R
R
L
A
P
----
L
L
G
--
N
--
E
L
-
Q
-
A
A
A
---
V
S
L
N
P
E
L
----------
R
R
T
L
R
A
G
E
S
A
G
A
L
A
G
I
V
S
G
S
G
P
T
----------------------------------------------------
65
Fugue
86.31
24%
-93
- C1 -
1H74
2
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
C
T
S
A
N
L
-
G
V
----
G
----
F
D
V
------------
F
G
L
C
L
K
E
---
P
Y
D
V
I
E
V
--
E
A
I
D
D
K
-
E
I
I
I
E
V
D
D
---
K
-
N
I
---
P
T
D
-
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
----
V
D
Y
A
S
Y
---------
G
E
L
A
S
SGAKHA
D
N
V
---------
A
P
-----
A
I
F
G
G
F
T
-
M
V
T
N
Y
E
P
L
E
----
V
L
H
I
P
I
D
F
K
-----
L
D
I
-
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
I
L
PKAVG
L
K
D
--------
L
V
N
N
V
-
G
------
K
A
C
G
----
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
----
Y
M
M
--
S
DK
V
I
-
E
-
P
V
R
---
G
K
L
I
P
N
Y
----------
F
K
I
K
E
E
V
K
D
K
-
V
Y
G
I
T
I
S
G
S
G
P
S
I
I
A
F
P
K
-
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
R
T
E
V
G
K
G
V
E
V
V
---------------
2
PsiBlast_PDB
86.09
35%
-74
- C1 -
4ED4
1
?
A:
[21-272]
-----
R
A
P
---
G
K
V
-
N
L
----
Y
----
L
A
V
G
D
L
----
Y
H
E
L
T
T
V
F
H
A
V
S
---
L
A
D
D
V
T
V
--
R
D
A
D
V
L
-
S
I
D
V
V
G
Q
G
---
E
G
T
V
---
P
-
T
-
D
-
E
R
N
L
A
W
Q
A
A
E
L
F
------
A
D
H
V
G
------
R
A
P
D
V
S
I
F
I
N
K
D
I
P
V
A
G
G
M
A
G
G
S
A
D
A
A
A
V
L
V
A
M
N
E
L
W
H
A
G
V
P
R
R
D
L
----
H
H
L
A
A
Q
---------
L
G
S
---------
D
V
---------
P
F
-----
A
L
H
G
G
T
A
-
L
G
T
G
R
G
E
-
Q
----
L
A
T
V
L
A
R
N
V
-----
F
H
W
-
V
F
A
F
A
D
G
G
L
A
T
P
Q
V
F
K
E
I
------
D
R
L
R
E
N
G---
D
P
P
R
L
-
A
------
E
A
D
E
----
L
L
G
A
L
A
A
G
D
A
R
R
L
A
P
----
L
L
G
--
N
--
E
L
-
Q
-
A
A
A
---
V
S
L
N
P
E
L
----------
R
R
T
L
R
A
G
E
S
A
G
A
L
A
G
I
V
S
G
S
G
P
T
----------------------------------------------------
64
Fugue
85.41
24%
-90
- C1 -
1FWK
1
KHSE_METJA
A:
[1-296]
M
K
V
R
V
K
A
P
---
C
T
S
A
N
L
----
G
----
V
--------
G
F
D
V
F
G
L
C
L
K
E
P
Y
-----
D
V
I
E
V
--
E
A
I
D
D
K
-
E
I
I
I
E
V
D
D
---
K
-
N
I
---
P
T
D
-
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
----
V
D
Y
A
S
Y
---------
G
E
L
---------
A
S
SGAKHA
D
N
V
A
P
-----
A
I
F
G
G
F
T
-
M
V
T
N
Y
E
P
L
E
----
V
L
H
I
P
I
D
F
K
-----
L
D
I
-
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
I
L
PKAVG
L
K
D
--------
L
V
N
N
V
-
G
------
K
A
C
G
----
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
----
Y
M
M
--
S
DK
V
I
-
E
-
P
V
R
---
G
K
L
I
P
N
Y
----------
F
K
I
K
E
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
P
S
I
I
A
F
P
K
-
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
R
T
E
V
G
K
G
V
E
V
V
---------------
63
Fugue
85.05
24%
-91
- C1 -
1H72
3
KHSE_METJA
C:
[1-296]
M
K
V
R
V
K
A
P
CTS
A
N
L
-
G
V
----
G
----
F
D
V
------------
F
G
L
C
L
K
E
---
P
Y
D
V
I
E
V
--
E
A
I
D
D
K
-
E
I
I
I
E
V
D
D
---
K
-
N
I
---
P
T
D
-
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
----
V
D
Y
A
S
Y
---------
G
E
L
---------
A
S
SGAKHADNV
A
P
-----
A
I
F
G
G
F
T
-
M
V
T
N
Y
E
P
L
E
----
V
L
H
I
P
I
D
F
K
-----
L
D
I
-
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
I
L
PKAVGL
K
D
--------
L
V
N
N
V
-
G
------
K
A
C
G
----
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
----
Y
M
M
--
S
DK
V
I
-
E
-
P
V
R
---
G
K
L
I
P
N
Y
----------
F
K
I
K
E
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
P
S
I
I
A
F
P
K
-
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
R
T
E
V
G
K
G
V
E
V
V
---------------
39
HHSearch
85.00
33%
-89
- C1 -
1UEK
-
ISPE_THET8
A:
[1-257]
--
M
E
R
L
A
P
---
A
K
V
-
N
L
----
G
LSVR
F
R
R
E
----
D
G
Y
H
E
L
H
T
L
F
A
P
F
S
---
L
A
D
R
L
V
V
--
E
P
V
S
S
G
--
L
H
F
Q
---------
G
---
P
-
Y
-
G
-
R
E
N
L
A
Y
R
A
A
S
L
Y
------
L
E
A
A
G
------
Q
P
G
G
V
R
I
L
L
E
K
R
I
P
E
G
A
G
L
G
G
G
S
S
D
A
A
Q
V
L
L
A
L
Q
A
L
Y
P
A
---
E
V
D
L
----
F
A
L
A
R
T
---------
L
G
A
---------
D
V
---------
P
F
-----
F
L
L
G
R
G
A
-
E
A
R
G
V
G
E
-
R
----
L
K
P
L
A
L
-
P
P
-----
V
P
A
-
V
V
F
F
P
G
L
R
V
P
T
P
L
V
Y
R
A
V
------
R
P
--------
E
D
F
G
P
D
L
------
P
V
E
A
----
I
L
E
A
L
A
R
G
E
E
P
P
Y
W
-----
N
S
L
--------
E
-
G
P
A
---
F
R
L
F
P
E
L
----------
K
E
V
R
G
R
M
R
A
L
G
L
R
G
V
L
M
S
G
S
G
S
A
F
F
G
L
A
E
G
P
D
H
A
R
R
A
A
E
A
L
R
A
W
-------------------------------
41
HHSearch
84.96
27%
-85
- C1 -
2WW4
2
ISPE_ECOLI
A:
[1-272]
M
R
T
Q
W
P
S
P
---
A
K
L
-
N
L
----
F
L
Y
I
T
G
Q
R
A
----
D
G
Y
H
T
L
Q
T
L
F
Q
F
L
D
---
Y
G
D
T
I
S
I
--
E
L
R
D
D
G
-
D
I
R
L
L
T
P
V
---
E
-
G
V
-----
E
-
H
-
E
D
N
L
I
V
R
A
A
R
L
L
------
M
K
T
A
A
D
S
GRLP
T
G
S
G
A
N
I
S
I
D
K
R
L
P
M
G
G
G
L
G
G
G
S
S
N
A
A
T
V
L
V
A
L
N
H
L
W
Q
C
G
L
S
M
D
E
L
----
A
E
M
G
L
T
---------
L
G
A
---------
D
V
---------
P
V
-----
F
V
R
G
H
A
A
-
F
A
E
G
V
G
E
-
I
----
L
T
P
V
D
P
-
P
E
-----
K
W
Y
-
L
V
A
H
P
G
V
S
I
P
T
P
V
I
F
K
D
P
------
E
L
--------
P
R
N
T
P
K
R
------
S
I
E
T
----
L
L
K
C
E
F
S
N
D
C
E
V
I
A
-----
R
-------------------
K
R
F
R
E
V
----------
D
A
V
L
S
W
L
L
E
-
Y
-
A
P
S
R
L
T
G
T
G
A
C
V
F
A
E
F
D
T
E
S
E
A
R
Q
V
L
E
Q
A
P
E
W
L
-
N
G
F
V
A
K
G
----------------------
43
HHSearch
83.37
23%
-92
* C1 *
1H72
3
KHSE_METJA
C:
[1-287]
M
K
V
R
V
K
A
P
---
C
T
S
-
A
N
----
L
----
G
V
G
F
D
----------
V
F
G
L
C
L
K
E--
P
Y
D
V
I
E
V
--
E
A
I
D
D
K
-
E
I
I
I
E
V
D
D
---
K
-
N
I
---
P
T
D
-
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
----
V
D
Y
A
S
Y
GELASSGAK
H
A
D
---------
N
V
---------
A
P
-----
A
I
F
G
G
F
T
-
M
V
T
N
Y
E
P
L
E
----
V
L
H
I
P
I
D
F
K
-----
L
D
I
-
L
I
A
I
P
N
I
S
I
N
T
K
E
A
R
E
I
L
------
P
K
--------
A
V
G
L
K
-
D
LVNNVG
K
A
C
G
----
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
-----
R
Y
M
--
M
--
S
D
-
K
-
V
I
E
PVR
G
K
L
I
P
N
Y
----------
F
K
I
K
E
E
V
K
D
-
K
V
Y
G
I
T
I
S
G
S
G
P
S
I
I
A
F
P
K
E
E
F
I
-
D
E
V
E
N
I
L
R
D
Y
Y
E
N
T
I
R
T
------------------------
17
PsiBlast_PDB
82.66
27%
-80
- C1 -
4RPF
1
KHSE_YERPN
A:
[7-285]
------
A
P
---
A
S
I
G
N
V
----
S
----
V
--------
G
F
D
V
L
G
A
A
V
S
P
I
D
GTL
L
G
D
C
V
S
V
--
T
A
-
A
E
----
R
F
S
L
H
N
E
G
-
R
-
F
V
SKL
P
-
D
-
D
P
K
Q
N
I
V
Y
Q
C
W
E
R
F
------
C
Q
E
M
G
------
K
E
I
P
V
A
M
V
L
E
K
N
M
P
I
G
S
G
L
G
S
S
A
C
S
V
V
A
G
L
M
A
M
N
E
F
C
G
Q
P
L
D
K
V
T
L
L
G
M
M
G
E
L
E
G
R
---------
V
S
G
---------
S
I
---------
H
F
D
N
V
A
P
C
Y
L
G
G
M
Q
-
L
I
L
E
Q
E
G
-
Y
----
I
S
Q
D
V
P
G
F
S
-----
D
W
L
W
V
M
A
Y
P
G
I
K
V
S
T
A
E
A
R
A
I
L
PAQYR-
R
Q
--------
D
C
I
T
H
-
G
R
-----
N
L
A
G
----
F
I
H
A
C
H
T
Q
Q
P
D
L
A
A
K
----
M
M
K
--
D
--
V
I
A
E
-
P
Y
R
---
T
Q
L
L
P
G
F
----------
A
A
A
R
Q
A
A
Q
D
I
G
A
L
A
C
G
I
S
G
S
G
P
T
L
F
A
V
C
N
D
Q
A
T
A
Q
R
M
A
G
W
L
Q
---------------------------------
15
PsiBlast_PDB
82.13
30%
-77
- C1 -
2WW4
2
ISPE_ECOLI
A:
[1-257]
M
R
T
Q
W
P
S
P
---
A
K
L
-
N
L
----
F
----
L
Y
I
T
G
Q
R
A
D
G
Y
H
T
L
Q
T
L
F
Q
F
L
D
---
Y
G
D
T
I
S
I
---
E
L
R
D
D
G
D
I
R
L
L
T
P
V
---
E
-
G
V
-----
E
-
H
-
E
D
N
L
I
V
R
A
A
R
L
L
M
K
T
A
A
D
S
G
R
L
P
------
T
G
S
G
A
N
I
S
I
D
K
R
L
P
M
G
G
G
L
G
G
G
S
S
N
A
A
T
V
L
V
A
L
N
H
L
W
Q
C
G
L
S
M
D
E
L
----
A
E
M
G
L
T
---------
L
G
A
---------
D
V
---------
P
V
-----
F
V
R
G
H
A
A
-
F
A
E
G
V
G
E
-
I
----
L
T
P
V
D
-
P
P
E
-----
K
W
Y
-
L
V
A
H
P
G
V
S
I
P
T
P
V
I
F
K
D
P
------
E
L
-----------
P
R
-
N
------
T
P
K
R
----
S
I
E
T
L
L
K
C
E
F
S
N
D
C
----------------
E
-
V
I
A
---
R
K
R
F
R
E
V
----------
D
A
V
L
S
W
L
L
E
Y
A
P
S
R
--
L
T
G
T
G
A
C
V
F
A
E
F
D
T
E
S
E
A
R
Q
V
--------------------------------------
45
HHSearch
81.45
22%
-85
- C1 -
4RPF
1
KHSE_YERPN
A:
[1-288]
S
M
V
K
I
Y
A
P
---
A
S
I
-
G
N
----
V
----
S
V
G
F
D
--
V
-----
L
G
A
A
V
S
P
I
D
GTL
L
G
D
C
V
S
V
--
T
A
A
E
R
---
F
S
L
H
N
E
G
RFV
S
-
K
L
---
P
-
D
D
P
-
K
Q
N
I
V
Y
Q
C
W
E
R
F
------
C
Q
E
M
G
------
K
E
I
P
V
A
M
V
L
E
K
N
M
P
I
G
S
G
L
G
S
S
A
C
S
V
V
A
G
L
M
A
M
N
E
F
C
G
Q
P
L
D
K
V
T
L
----
L
G
M
M
G
E
---------
L
E
G
R
V
SGSIHF
D
N
V
---------
A
P
-----
C
Y
L
G
G
M
Q
L
I
L
E
Q
E
G
Y
-
I
----
S
Q
D
V
P
G
F
S
D
-----
W
L
W
-
V
M
A
Y
P
G
I
K
V
S
T
A
E
A
R
A
I
L
------
P
A
--------
Q
Y
R
R
Q
-
D
C
I
T
H
G
R
N
L
A
G
----
F
I
H
A
C
H
T
Q
Q
P
D
L
A
A
-----
K
M
M
--
K
--
D
V
-
I
A
E
P
Y
R--
T
Q
L
L
P
G
F
----------
A
A
A
R
Q
A
A
Q
D
I
G
A
L
A
C
G
I
S
G
S
G
P
T
L
F
A
V
C
N
D
Q
A
T
A
Q
R
M
A
G
W
L
Q
N
H
Y
------------------------------
66
Fugue
80.65
24%
-88
- C1 -
1H72
3
KHSE_METJA
C:
[1-296]
M
K
V
R
V
K
A
P
---
C
T
S
A
N
L
----
G
----
V
G
F
D
--------
V
F
G
L
C
L
K
--
E
---
P
Y
D
V
I
E
V
--
E
A
I
D
D
K
-
E
I
I
I
E
V
D
D
---
K
-
N
I
---
P
T
D
-
P
-
D
K
N
V
A
G
I
V
A
K
K
M
------
I
D
D
F
N
------
I
G
K
G
V
K
I
T
I
K
K
G
V
K
A
G
S
G
L
G
S
S
A
A
S
S
A
G
T
A
Y
A
I
N
E
L
F
K
L
N
L
D
K
L
K
L
----
V
D
Y
A
S
Y
---------
G
E
L
---------
A
S
SGAKHADNV
A
P
-----
A
I
F
G
G
F
T
-
M
V
T
N
Y
----EPLE
V
L
H
I
P
I
--
D
FKLDI
L
I
A
-
I
P
N
---
I
S
I
N
T
K
E
A
R
E
I
--------
L
PKAVGLKD
L
V
N
N
V
-
G
------
K
A
C
G
----
M
V
Y
A
L
Y
N
K
D
K
S
L
F
G
R
----
Y
M
M
SD
K
--
V
I
-
E
-
P
V
R
---
G
K
-----LIPNYFKIKE
E
V
K
D
K
------
V
Y
G
I
T
I
S
G
S
G
P
S
I
I
A
F
P
K
-
E
E
F
I
D
E
V
E
N
I
L
R
D
Y
Y
E
---------------NTIRTEVGKGVEVV
14
PsiBlast_PDB
79.88
31%
-80
- C1 -
2VF3
6
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
12
PsiBlast_PDB
79.26
31%
-80
- C1 -
2V34
7
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
23
PsiBlast_CBE
79.17
31%
-78
- C1 -
2V34
6
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
26
PsiBlast_CBE
78.83
31%
-80
- C1 -
2V2Q
8
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
22
PsiBlast_CBE
78.74
31%
-79
- C1 -
2V8P
5
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
21
PsiBlast_CBE
78.59
31%
-79
- C1 -
2VF3
6
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
9
PsiBlast_PDB
78.36
31%
-80
- C1 -
2V2Q
8
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
13
PsiBlast_PDB
78.02
31%
-77
- C1 -
2V8P
5
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
24
PsiBlast_CBE
77.99
31%
-79
- C1 -
2V2Z
5
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
11
PsiBlast_PDB
77.93
31%
-80
- C1 -
2V2Z
5
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
10
PsiBlast_PDB
77.49
31%
-79
- C1 -
2V2V
9
ISPE_AQUAE
A:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------
25
PsiBlast_CBE
77.19
31%
-78
- C1 -
2V2V
9
ISPE_AQUAE
B:
[9-246]
------
S
P
---
A
K
I
-
N
L
----
G
----
L
W
V
L
G
R
L
P
S
G
Y
H
E
I
L
T
L
Y
Q
E
I
P
---
F
Y
D
E
I
Y
I
--
R
E
G
V
----
L
R
V
E
T
-
N
---
I
-
G
I
---
P
-
Q
-
E
-
E
-
N
L
V
Y
K
G
L
R
E
F
------
E
R
I
T
G
------
I
E
I
N
Y
S
I
F
I
Q
K
N
I
P
P
G
A
G
L
G
G
G
S
S
N
L
A
V
V
L
K
K
V
N
E
L
L
G
S
P
L
S
E
E
E
L
----
R
E
L
V
G
S
---------
I
S
A
---------
D
A
---------
P
F
-----
F
L
L
G
K
S
A
-
I
G
R
G
K
G
E
-
V
----
L
E
P
V
E
T
E
I
S
-----
G
K
I
-
T
L
V
I
P
Q
V
S
S
S
T
G
R
V
Y
S
S
L
------
R
E
--------
E
H
F
V
T
-
P
------
E
Y
A
-----------
E
E
K
I
Q
R
I
I
S
GEVE
E
I
E
--
N
--
V
L
-
G
-
D
I
A
---
R
E
L
Y
P
E
I
----------
N
E
V
Y
R
F
V
E
Y
L
G
F
K
P
-
F
V
S
G
S
G
S
T
V
Y
--------------------------------------------------