@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5349: (2016-03-06 )
MSERAPLVIIGTGLAGYNLAREWRKLDGETPLLMITADDGRSYSKPMLSTGFSKNKDADGLAMAEPGAMAEQLNARILTHTRVTGIDPGHQRIWIGEEEVRYRDLVLAWGAEPIRVPVEGDAQDALYPINDLEDYARFRQAAAGKRRVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFHLGPVLASLKKAGEGLEAHLSDGEVIPCDLVVSAVGLRPRTELAFAAGLAVNRGIVVDRSLRTSHANIYALGDCAEVDGLNLLYVMPLMACARALAQTLAGNPSQVAYGPMPVTVKTPACPLVVSPPPRGMDGQWLVEGSGTDLKVLCRDTAGRVIGYALTGAAVNEKLALNKELPGLMA
Atome Classification :
(20 SA)
.........10........20........30........40---..-----......---------50----.----.-.-----.---------....-.60---------.-------.---.----------......70.---------------------.......80........90.....------.-..100.......110....-...----120-.......130.......140--.--......150.......160....-...170--.........180.......190.......200.......210....-.-------------------.-.-220.......-230.......240.....--..250......--.---..260.......270.......280-----..-----.-------.....290.......300.....--.-.310.-........--------------320.......330......-.---------340-----------.----------.--....--------------...350..-.....360...---.-----.-..370-........380..-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSERA
P
L
V
I
I
GTGLA
G
Y
N
L
A
R
E
W
R
K
LDGET
P
L
L
M
I
TADDGR---SY-----SK
P
M
L
S---------T-----G----F-S-----K---------NKDA-DG----------
L
-------
A
---M----------AEP
G
A
M
A
E
Q
---------------------LN
A
R
I
L
T
HTRVTGIDPGH
Q
R
I
W
I
G
------
E
-
E
E
V
R
Y
R
D
L
V
L
AWGA
E
P
I
R
V-PVE----GDA-QDALYPI
N
D
L
E
D
Y
A
R
F
R
Q
AA--A--GK
R
R
V
L
L
L
GAGLIG
C
E
F
A
N
DLSS-G
G
Y
Q
----
L
D
V
VA
P
C
E
Q
V
M
P
G
LL
H
P
A
A
A
K
A
V
Q
A
G
L
E
GL
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A-G-------------------E-
G
-
L
E
AHLSDG
E
V
-
I
P
C
D
L
V
V
S
A
VGLRPR
T
E
L
--
A
F
A--AGLAVN--R---
G
I
V
V
DRSLRTSH
A
N
I
Y
A
LGDCAEV------DG-----L-------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
LAGNP--S-QV--A-YGP
M
P
V
T
V
--------------KTPAC
P
L
V
VSPPPRGMDG
Q
-
W
---------
L
-------------
V
----------E--GSGT--------------
D
L
K
V
L
C
RD-TAG
R
V
I
G
Y
A
LT---G-----A-AVN-
E
-
K
LALNKELPGLMA-------------------
2
PsiBlast_PDB
99.25
100%
-145
- C1 -
2V3B
1
RURE_PSEAE
A:
[4-384]
---
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
---
S
Y
-----
S
K
P
M
L
S
---------
T
-----
G
----
F
-
S
-----
K
---------
N
K
D
A
-
D
G
----------
L
-------
A
---
M
----------
A
E
P
G
A
M
A
E
Q
---------------------
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
------
E
-
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
V
E
----
G
D
A
-
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
-
G
G
Y
Q
----
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-
G
-------------------
E
-
G
-
L
E
A
H
L
S
D
G
E
V
-
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
--
A
F
A
--
A
G
L
A
V
N
--
R
---
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
------
D
G
-----
L
-------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
--
S
-
Q
V
--
A
-
Y
G
P
M
P
V
T
V
--------------
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
-
W
---------
L
-------------
V
----------
E
--
G
S
G
T
--------------
D
L
K
V
L
C
R
D
-
T
A
G
R
V
I
G
Y
A
L
T
---
G
-----
A
-
A
V
N
-
E
-
K
L
A
L
N
K
E
L
P
G
L
M
A
-------------------
1
PsiBlast_PDB
98.79
100%
-140
- C1 -
2V3A
9
RURE_PSEAE
A:
[4-384]
---
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
---
S
Y
-----
S
K
P
M
L
S
---------
T
-----
G
----
F
-
S
-----
K
---------
N
K
D
A
-
D
G
----------
L
-------
A
---
M
----------
A
E
P
G
A
M
A
E
Q
---------------------
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
------
E
-
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
V
E
----
G
D
A
-
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
-
G
G
Y
Q
----
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-
G
-------------------
E
-
G
-
L
E
A
H
L
S
D
G
E
V
-
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
--
A
F
A
--
A
G
L
A
V
N
--
R
---
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
------
D
G
-----
L
-------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
--
S
-
Q
V
--
A
-
Y
G
P
M
P
V
T
V
--------------
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
-
W
---------
L
-------------
V
----------
E
--
G
S
G
T
--------------
D
L
K
V
L
C
R
D
-
T
A
G
R
V
I
G
Y
A
L
T
---
G
-----
A
-
A
V
N
-
E
-
K
L
A
L
N
K
E
L
P
G
L
M
A
-------------------
21
HHSearch
96.50
97%
-137
- C1 -
2V3A
9
RURE_PSEAE
A:
[4-384]
---
R
A
P
L
V
I
I
G
T
G
L
A
G
Y
N
L
A
R
E
W
R
K
L
D
G
E
T
P
L
L
M
I
T
A
D
D
G
R
---
S
Y
-----
S
K
P
M
L
S
---------
T
-----
G
----
F
-
S
-----
K
---------
N
K
D
A
-
D
G
----------
L
-------
A
---
M
----------
A
E
P
G
A
M
A
E
Q
---------------------
L
N
A
R
I
L
T
H
T
R
V
T
G
I
D
P
G
H
Q
R
I
W
I
G
------
E
-
E
E
V
R
Y
R
D
L
V
L
A
W
G
A
E
P
I
R
V
-
P
V
E
----
G
D
A
-
Q
D
A
L
Y
P
I
N
D
L
E
D
Y
A
R
F
R
Q
A
A
--
A
--
G
K
R
R
V
L
L
L
G
A
G
L
I
G
C
E
F
A
N
D
L
S
S
-
G
G
Y
Q
----
L
D
V
V
A
P
C
E
Q
V
M
P
G
L
L
H
P
A
A
A
K
A
V
Q
A
G
L
E
G
L
G
V
R
F
H
L
G
P
V
L
A
S
L
K
K
A
-
G
-------------------
E
-
G
-
L
E
A
H
L
S
D
G
E
V
-
I
P
C
D
L
V
V
S
A
V
G
L
R
P
R
T
E
L
--
A
F
A
--
A
G
L
A
V
N
--
R
---
G
I
V
V
D
R
S
L
R
T
S
H
A
N
I
Y
A
L
G
D
C
A
E
V
------
D
G
-----
L
-------
N
L
L
Y
V
M
P
L
M
A
C
A
R
A
L
A
Q
T
L
A
G
N
P
--
S
-
Q
V
--
A
-
Y
G
P
M
P
V
T
V
--------------
K
T
P
A
C
P
L
V
V
S
P
P
P
R
G
M
D
G
Q
-
W
---------
L
-------------
V
----------
E
--
G
-
S
G
--------------
T
D
L
K
V
L
C
R
D
T
A
G
R
V
I
G
Y
A
L
T
---
G
-----
A
-
A
V
N
-
E
-
K
L
A
L
N
K
E
L
P
G
L
M
A
-------------------
32
HHSearch
64.29
27%
-120
* C1 *
3FG2
2
?
P:
[1-380]
---
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
P
G
R
I
A
L
I
N
D
E
K
H
L
---
P
Y
-----
Q
R
P
P
L
S
---------
K
-----
A
----
Y
L
K
-----
S
---------
G
G
D
P
-
N
S
----------
L
-------
M
--------------
F
R
P
E
K
F
F
Q
D
---------------------
Q
A
I
E
L
I
S
-
D
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
S-----
G
-
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
V
P
----
N
A
S
-
L
P
D
V
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
--
P
--
D
K
K
H
V
V
V
I
G
A
G
F
I
G
L
E
F
A
A
T
A
R
A
-
K
G
L
E
----
V
D
V
V
E
L
A
P
R
V
M
A
R
V
V
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
R
A
T
E
I
A
A
E
-
G
-------------------
D
-
R
V
T
G
V
V
L
S
D
G
N
T
-
L
P
C
D
L
V
V
V
G
V
G
V
I
P
N
V
E
I
--
A
A
A
--
A
G
L
P
T
A
--
A
---
G
I
I
V
D
Q
Q
L
L
T
S
D
P
H
I
S
A
I
G
D
C
A
L
F
------
E
S
-----
V
RFGETM-
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
A
--
K
-
P
Y
--
D
-
G
Y
P
W
F
W
S
D
--------------
Q
G
D
D
-
K
L
Q
I
V
G
L
T
A
G
F
D
Q
V
V
I
---------
R
-------------
G
----------
S
--
V
A
E
R
--------------
S
F
S
A
F
C
Y
--
K
A
G
K
L
I
G
I
E
S
V
---
N
-----
R
-
A
A
D
-
H
-
V
F
G
R
K
I
--------------------------
38
HHSearch
62.42
23%
-114
- C1 -
3ICS
3
?
A:
[34-443]
-
W
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
E
D
E
I
I
M
V
E
R
G
E
Y
I
---
S
F
-----
A
N
C
G
L
P
---------
Y
-----
Y
----
I
-
G
-----
G
---------
V
I
T
E
R
Q
K
----------
L
-------
L
---
V
----------
Q
T
V
E
R
M
S
K
R
---------------------
F
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
NVTTN
E
T
-
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
-
S
I
P
----
G
I
E
E
A
K
A
L
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
D
E
K
--
K
P
R
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
-
R
G
I
E
----
V
T
L
V
E
M
A
N
Q
V
M
P
P
-
I
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
-
G
-----------------------
A
V
V
R
L
K
S
G
S
V
-
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
--
A
K
G
--
A
G
L
A
L
G
VR
G
---
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
------
K
D
-----
F
VTE
T
E
T
-
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D-
S
-
L
Y
KG
T
-
L
G
T
S
V
A
K
V
----------------
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
-
L
N
I
P
Y
E
V
V
H
V
Q
A
N
SHAGY------
Y
----------
P
--
N
A
T
P
--------------
V
L
I
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
---
G
-----
R
-
D
G
V
-
D
K
R
M
D
V
I
A
--------------------------
31
HHSearch
60.20
25%
-121
- C1 -
1XHC
1
?
A:
[9-355]
----
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
-
T
--
Y
E
V
T
V
I
D
K
E
P
V
P
---
Y
Y
-----
S
K
P
M
L
S
---------
H
-----
Y
----
I
-
A
-----
G
---------
F
I
P
R
-
N
R
----------
L
-------
F
--------------
P
Y
S
L
D
W
Y
R
K
---------------------
R
G
I
E
I
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
------
K
-
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
I
K
----
G
K
---
E
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
--
E
--
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
-
A
G
Y
H
----
V
K
L
I
H
R
G
A
M
F
L
G
--
L
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
-
G
-------------------------
V
-
L
T
N
S
G
F
-
I
E
G
K
V
K
I
C
A
I
G
I
V
P
N
V
D
L
--
A
R
R
--
S
G
I
H
T
G
--
R
---
G
I
L
I
D
D
N
F
R
T
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
------
S
G
-----
I
-------
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
E
P
--
R
-
R
Y
--
N
-
F
K
F
R
S
T
V
F
--------------
K
F
G
K
L
Q
I
A
I
I
G
N
T
K
G
E
G
K
W
-
I
----------------------------------------
E
--------------
D
N
T
K
V
F
Y
-------
I
G
A
V
V
F
---
N
-----
D
-
I
R
K
-
A
---------------------------------
22
HHSearch
58.76
21%
-120
- C1 -
3KLJ
1
NROR_CLOAB
A:
[8-359]
--
K
S
T
K
I
L
I
L
G
A
G
P
A
G
F
S
A
A
K
A
A
L
G
K
C
--
D
D
I
T
M
I
N
S
E
K
Y
L
---
P
Y
-----
Y
R
P
R
L
N
---------
E
-----
I
----
I
-
A
-----
K
---------
N
K
S
I
-
D
D
----------
I
-------
L
--------------
I
K
K
N
D
W
Y
E
K
---------------------
N
N
I
K
V
I
T
S
E
F
A
T
S
I
D
P
N
N
K
L
V
T
L
K
S-----
G
-
E
K
I
K
Y
E
K
L
I
I
A
S
G
S
I
A
N
K
I
-
K
V
P
----
H
A
---
D
E
I
F
S
L
Y
S
Y
D
D
A
L
K
I
K
D
E
C
--
K
--
N
K
G
K
A
F
I
I
G
G
G
I
L
G
I
E
L
A
Q
A
I
I
D
-
S
G
T
P
----
A
S
I
G
I
I
L
E
Y
P
L
E
R
Q
L
D
R
D
G
G
L
F
L
K
D
K
L
D
R
L
G
I
K
I
Y
T
N
S
N
F
E
E
M
-----------------------------------
G
D
L
-
I
R
S
S
C
V
I
T
A
V
G
V
K
P
N
L
D
F
--
I
K
D
--
T
E
I
A
S
K
--
R
---
G
I
L
V
N
D
H
M
E
T
S
I
K
D
I
Y
A
C
G
D
V
A
E
F
------
Y
G
-----
K
-------
N
P
G
L
I
N
I
A
N
K
Q
G
E
V
A
G
L
N
A
C
G
E
D
--
A
-
S
Y
--
S
E
I
I
P
S
P
-
I
L
--------------
K
V
S
G
I
S
I
I
S
C
G
D
I
E
N
N
K
P
S
-
K
---------
V
-------------
F
R
---------
S
--
T
Q
E
D
--------------
K
Y
I
V
C
M
L
--
K
E
N
K
I
D
A
A
A
V
I
---
G
-----
D
-
V
S
L
-
G
---------------------------------
25
HHSearch
57.32
23%
-105
- C1 -
3NTD
2
?
A:
[1-427]
---
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
T
A
E
I
I
M
F
E
R
G
E
Y
V
---
S
F
-----
A
N
C
G
L
P
---------
Y
-----
H
----
I
-
S
-----
G
---------
E
I
A
Q
R
S
A
----------
L
-------
V
---
L
----------
Q
T
P
E
S
F
K
A
R
---------------------
F
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
RLLDG
S
E
-
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
-
P
I
P
----
G
V
D
-
N
P
L
T
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
--
Q
MN
N
V
E
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
-
L
G
I
K
----
T
T
L
L
E
L
A
D
Q
V
M
T
P
-
V
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
-
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
-
H
-
L
S
L
T
L
S
N
G
E
L
-
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
--
A
R
D
--
A
G
L
A
I
G
EL
G
---
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
------
Q
D
-----
F
VTG
Q
A
C
-
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
E
--
E
-
R
Y
Q-
G
-
T
Q
G
T
A
I
C
K
--------------
V
F
D
L
-
A
V
G
A
T
G
K
N
E
K
Q
L
K
Q
-
A
G
I
A
F
-----
E
K
V
Y
V
HTASHASY-
Y
----------
P
--
G
A
E
V
--------------
V
S
F
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
---
G
-----
K
-
D
G
I
D
K
-
R
I
D
V
M
A
--------------------------
7
PsiBlast_PDB
57.15
26%
-109
- C1 -
1XHC
1
?
A:
[9-359]
----
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
---
L
S
Q
T
Y
E
V
T
V
I
D
K
E
P
V
P
---
Y
Y
-----
S
K
P
M
L
S
H
Y
I
------
A
-----
G
----
F
I
P
-----
R
---------
N
R
L
--------------
F
-------
P
---
Y
----------
S
L
D
W
Y
R
K
R
G
---------------------
I
E
I
R
L
A
E
E
A
K
L
--
I
D
R
G
R
K
V
V
I
T
E
------
K
-
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
I
K
----
G
---
K
E
Y
L
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
--
E
--
N
S
G
E
A
I
I
I
G
G
G
F
I
G
L
E
L
A
G
N
L
A
E
-
A
G
Y
H
----
V
K
L
I
H
R
G
A
M
F
L
G
--
L
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
-
G
-------------------
V
-
L
-
T
N
S
G
F
I
E
G
K
V
-
K
I
C
-----
A
I
G
I
V
P
N
V
D
L
--
A
R
R
--
S
G
I
H
T
G
--
R
---
G
I
L
I
D
D
N
F
R
T
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
------
S
G
-----
I
-------
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
E
P
--
R
-
R
Y
--
N
-
F
K
F
R
S
T
V
F
--------------
K
F
G
K
L
Q
I
A
I
I
G
N
T
K
G
-
E
G
K
-
W
---------
I
-------------
E
----------
D
--
N
T
------------------
K
V
F
Y
--------
I
G
-
A
V
V
---
F
-----
N
-
D
I
R
-
K
-
A
T
K
L
E
---------------------------
43
Fugue
57.00
23%
-112
- C1 -
1D7Y
1
?
A:
[5-405]
-
A
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
---
P
Y
-----
D
R
P
P
L
S
---------
K
-----
D
----
F
-
M
-----
A
---------
H
G
D
A
-
E
K
----------
I
-------
R
---
L
----------
D
----
C
K
R
A
---------------------
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
------
D
G
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
-
P
T
L
----
Q
G
A
-
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
--
R
--
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
-
A
G
V
H
----
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
-------------------------
D
-
G
V
V
L
L
D
D
G
T
R
-
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
--
A
R
A
--
A
G
L
A
C
D
--
D
---
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
NPLSG
R
F
-----
E
-------
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
--
A
-
P
G
--
Y
-
A
E
L
P
W
Y
W
S
--------------
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
-
V
---------
R
-------------
G
----------
E
--
V
S
L
D
--------------
A
P
K
F
T
L
I
E
-
L
Q
K
G
R
I
V
G
A
T
C
---
V
-----
N
-
N
A
R
-
D
-
F
A
P
L
R
R
L
L
A
V
G
A
K
PD
R
A
A
L
A
DPAT
D
L
R
K
L
A
A
A
27
HHSearch
56.90
24%
-124
- C1 -
3IWA
1
?
A:
[4-429]
----
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
D
P
E
A
H
V
T
M
I
D
Q
A
---------------------------------------------------------------------------------------------------------------------------------
V
E
A
L
V
E
T
R
A
H
A
I
D
R
A
A
H
T
V
E
I
E
NLRTG
E
R
-
R
T
L
K
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
P
-
P
V
E
----
G
M
D
-
L
A
G
V
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
SA
G
--
E
V
S
K
A
V
I
V
G
G
G
F
I
G
L
E
M
A
V
S
L
A
D
M
W
G
I
D
----
T
T
V
V
E
L
A
D
Q
I
M
P
G
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
H
T
G
E
K
V
V
R
L
E
G
E
-
N
-------------------
G
-
K
-
V
A
R
V
I
T
D
K
R
T
-
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
--
A
R
D
--
A
G
L
E
L
D
PR
G
---
A
I
I
V
D
T
R
M
R
T
S
D
P
D
I
F
A
G
G
D
C
V
T
I
------
P
N
-----
L
VTG
K
P
G
-
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
G
D
--
A
-
T
F
--
P
-
G
A
V
G
S
W
A
V
--------------
K
L
F
E
G
S
A
S
G
A
G
L
T
V
E
G
A
L
R
-
E
GYD
A
V
----
N
V
H
V
E
Q-------------------------
I
--------------
M
T
L
Q
L
V
V
D
R
P
T
R
R
V
L
G
I
Q
G
F
S
TL
G
-----
D
-
A
L
T
-
A
-
R
I
N
A
V
A
T
-------------------------
30
HHSearch
56.76
24%
-116
- C1 -
2GQW
7
?
A:
[6-372]
--
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
---
P
Y
-----
D
R
P
P
L
S
---------
K
-----
D
----
F
-
M
-----
A
---------
H
G
D
A
-
E
K
----------
I
-------
R
-----------------
L
D
C
K
R
A
---------------------
P
E
V
E
W
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D-----
G
-
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
L
Q
----
G
A
T
--
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
--
R
--
P
Q
S
R
L
L
I
V
G
G
G
V
I
G
L
E
L
A
A
T
A
R
T
-
A
G
V
H
----
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
--------------------------
V
V
L
L
D
D
G
T
R
-
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
--
A
R
A
--
A
G
L
A
C
D
--
D
---
G
I
F
V
D
A
Y
G
R
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
------
R
N
-----
P
LSGRFE-
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
A-
P
-
G
Y
--
A
-
E
L
P
W
Y
W
S
---------------
D
Q
G
A
L
R
I
Q
V
A
G
L
A
S
G
D
E
E
I
-
V
---------
R
-------------
G
----------
E
VS
L
D
A
P
--------------
K
F
T
L
I
E
-
L
-
Q
K
G
R
I
V
G
A
T
C
V
---
N
-----
N
-
A
R
------------------------------------
26
HHSearch
56.54
22%
-119
- C1 -
3OC4
2
?
A:
[3-401]
----
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
S
R
K
K
Y
P
Q
A
E
I
S
L
I
D
K
Q
A
T
V
---
G
Y
-----
L
S
G
------------------------------------------------------------------
R
---
Y
----------
I
T
-
E
E
E
L
R
R
---------------------
Q
K
I
Q
L
L
L
N
R
E
V
V
A
M
D
V
E
N
Q
L
I
A
W
T
R
KE
E
--
Q
-
Q
W
Y
S
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
-
Q
I
R
----
G
S
Q
-
T
E
K
L
L
K
Y
K
F
L
S
----
A
V
P
L
L
--
E
--
N
S
Q
T
V
A
V
I
G
A
G
P
I
G
M
E
A
I
D
F
L
V
K
-
M
K
K
T
----
V
H
V
F
E
S
L
E
N
L
L
P
K
Y
F
D
K
E
M
V
A
E
V
Q
K
S
L
E
K
Q
A
V
I
F
H
F
E
E
T
V
L
G
I
E
E
T
-
A
-------------------
N
-
G
-
I
V
L
-
E
T
S
E
Q
E
-
I
S
C
D
S
G
I
F
A
L
N
L
H
P
Q
L
A
Y
--
L
D
K
---
K
I
Q
R
N
LD
Q
---
T
I
A
V
D
A
Y
L
Q
T
S
V
P
N
V
F
A
I
G
D
C
I
S
V
------
M
N
-----
E
PVA
E
T
F
-
Y
A
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
L
E
E
K
T
--
H
-
R
F
I-
G
-
S
L
R
T
M
G
T
K
--------------
V
G
D
Y
-
Y
L
A
S
T
G
L
T
E
T
E
G
L
F
-
F
PQT
L
A
S
I
--
I
-------------
V
R
Q
P
A
PPL---
Q
--
H
G
T
E
--------------
I
L
G
K
L
I
Y
D
K
V
T
Q
R
V
L
G
A
Q
L
C
---
S
-----
K
N
N
C
L
-
E
-
K
I
N
T
L
A
--------------------------
41
HHSearch
56.53
24%
-114
- C1 -
3LXD
1
?
A:
[7-383]
-
A
E
R
A
D
V
V
I
V
G
A
G
H
G
G
A
Q
A
A
I
A
L
R
Q
N
G
F
E
G
R
V
L
V
I
G
R
E
P
E
I
---
P
Y
-----
E
R
P
P
L
S
K--------
E
-----
Y
----
L
-
A
-----
R
---------
E
K
T
F
-
E
R
----------
I
-------
C
--------------
I
R
P
A
Q
F
W
E
D
---------------------
K
A
V
E
M
K
L
G
A
E
V
V
S
L
D
P
A
A
H
T
V
K
L
G
D-----
G
-
S
A
I
E
Y
G
K
L
I
W
A
T
G
G
D
P
R
R
L
-
S
C
V
----
G
A
D
-
L
A
G
V
H
A
V
R
T
K
E
D
A
D
R
L
M
A
E
L
--
D
A
-
G
A
K
N
A
V
V
I
G
G
G
Y
I
G
L
E
A
A
A
V
L
T
K
-
F
G
V
N
----
V
T
L
L
E
A
L
P
R
V
L
A
R
V
A
G
E
A
L
S
E
F
Y
Q
A
E
H
R
A
H
G
V
D
L
R
T
G
A
A
M
D
C
I
E
G
D
-
G
-------------------
T
K
V
-
T
G
V
R
M
Q
D
G
S
V
-
I
P
A
D
I
V
I
V
G
I
G
I
V
P
C
V
G
A
--
L
I
S
--
A
G
A
S
G
G
--
N
---
G
V
D
V
D
E
F
C
R
T
S
L
T
D
V
Y
A
I
G
D
C
A
A
H
------
A
N
-----
D
FADG
A
V
I
R
L
E
S
V
Q
N
A
N
D
M
A
T
A
A
A
K
D
I
C
G
A
P
--
V
-
P
Y
--
K
-
A
T
P
W
F
W
S
---------------
N
Q
Y
D
L
K
L
Q
T
V
G
L
S
T
G
H
D
N
A
V
L
---------
R
-------------
G
----------
D
--
P
A
T
R
--------------
S
F
S
V
V
Y
-
L
-
K
G
G
K
V
V
A
L
D
C
V
---
N
-----
M
-
V
K
------------------------------------
24
HHSearch
55.13
22%
-110
- C1 -
3EF6
10
TODA_PSEP1
A:
[3-371]
----
T
H
V
A
I
I
G
N
G
V
G
G
F
T
T
A
Q
A
L
R
A
E
G
F
E
G
R
I
S
L
I
G
D
E
P
H
L
---
P
Y
-----
D
R
P
S
L
S
---------
K
-----
A
----
V
-
L
-----
D
---------
G
S
L
E
-
R
P
----------
P
-------
I
--------------
L
A
E
A
D
W
Y
G
E
---------------------
A
R
I
D
M
L
T
G
P
E
V
T
A
L
D
V
Q
T
R
T
I
S
L
D
D-----
G
-
T
T
L
S
A
D
A
I
V
I
A
T
G
S
R
A
R
T
M
-
A
L
P
----
G
S
Q
-
L
P
G
V
V
T
L
R
T
Y
G
D
V
Q
V
L
R
D
S
W
--
T
--
S
A
T
R
L
L
I
V
G
G
G
L
I
G
C
E
V
A
T
T
A
R
K
-
L
G
L
S
----
V
T
I
L
E
A
G
D
E
L
L
V
R
V
L
G
R
R
I
G
A
W
L
R
G
L
L
T
E
L
G
V
Q
V
E
L
G
T
G
V
V
G
F
S
G
E
-
G
-------------------
Q
-
L
-
E
Q
V
M
A
S
D
G
R
S
-
F
V
A
D
S
A
L
I
C
V
G
A
E
P
A
D
Q
L
--
A
R
Q
--
A
G
L
A
C
D
--
R
---
G
V
I
V
D
H
C
G
A
T
L
A
K
G
V
F
A
V
G
D
V
A
S
W
------
P
L
-----
R
A
G
G
R
R
--
S
L
E
T
Y
M
N
A
Q
R
Q
A
A
A
V
A
A
A
I
L
G
K
N
--
V
-
S
A
--
P
-
Q
L
P
V
S
W
T
---------------
E
I
A
G
H
R
M
Q
M
A
G
D
I
E
G
P
G
D
F
-
V
-----------------------
S
----------
R
--
G
M
P
G
--------------
S
G
A
A
L
L
F
R
L
Q
E
R
R
I
Q
A
V
V
A
V
---
D
-----
A
-
P
R
------------------------------------
44
Fugue
54.92
19%
-110
- C1 -
1M6I
1
AIFM1_HUMAN
A:
[8-488]
A
P
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
G
A
R
V
L
I
V
S
E
D
P
E
L
---
P
Y
-----
M
R
P
P
L
S
---------
K
-----
E
----
L
-
W
-----
F
---------
S
P
N
V
-
T
K
----------
T
-------
L
---
R
----------
F
K
Q
W
N
G
K
E
R
S
IYFQPPSFYVSAQDLPHIEN
G
G
V
A
V
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
------
D
G
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
-
S
A
I
D
R
AG
A
E
V
-
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
--
R
--
E
V
K
S
I
T
I
I
G
G
G
F
L
G
S
E
L
A
C
A
L
G
R
-
K
A
R
A
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
L
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
-
S
-------------------
G
-
K
-
L
L
I
K
L
K
D
G
R
K
-
V
E
T
D
H
I
V
A
A
V
G
L
E
P
N
V
E
L
--
A
K
T
--
G
G
L
E
I
D
--
S
DFG
G
F
R
V
N
A
E
L
Q
A
R
-
S
N
I
W
V
A
G
D
A
A
C
F
------
Y
D
IKL
G
R
R
-------
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
A
--
K
-
P
Y
--
W
-
H
Q
S
M
F
W
S
D
LGPD
V
G
Y
E
A
I
G
LVD
S
S
L
P
T
V
G
V
F
A
K
A
T
A
Q
D
N
P
K
-
S
---------
A
-------------
T
----------
E
--
Q
S
G
T
GI
R
S
E
S
E
TESEASY
G
K
G
V
I
F
Y
L
-
R
D
K
V
V
V
G
I
V
L
W
---
N
IFNR
M
P
-
I
A
R
-
K
-
I
I
K
D
G
E
Q
H
E
D
L
N
E
V
A
K
L
F--------------
36
HHSearch
54.44
20%
-106
- C1 -
1ONF
1
GSHR_PLAFK
A:
[2-467]
---
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
A
A
A
R
R
A
A
R
H
N
--
A
K
V
A
L
V
E
K
S
R
L
G
GTC
V
N
VGC
V
P
K
K
I
M
F
N
---------
A
A
S
V
H
D
I
----
L
-
E
N
SRHY
G
FD
T
K
F
----
S
F
N
L
-
P
L
----------
L
V
E
R
R
D
K
Y
I
Q
R
L
N
----------
N
I
Y
R
Q
N
L
S
K
---------------------
D
K
V
D
L
Y
E
G
T
-
A
S
F
L
---------------------
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
-
P
V
K
----
G
I
E
---
N
T
I
S
S
D
E
F
F
N
---
I
------
K
--
E
S
K
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
K
R
-
L
G
I
D
----
S
Y
I
F
A
R
G
N
R
I
L
R
K
-
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
K
K
V
-
S
D------------------
K
-
N
-
L
S
I
H
L
S
D
G
R
I
Y
E
H
F
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
--
L
K
L
EK
L
N
V
E
T
N
N-
N
---
Y
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
C
C
M
V
------
K
-------F
Y
-----
N
V
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
F
L
K
K
--
T
R
K
T
--
N
-
Y
K
L
I
P
T
V
I
--------------
F
S
H
P
-
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
-
I
YGKEN
V
---
K
I
Y
E
S
K
F
T
N
LFFSV
Y
DIE-------
P
E-
L
K
E
K
--------------
T
Y
L
K
L
V
C
V
G
K
D
E
L
I
K
G
L
H
I
I
---
G
-----
L
-
N
A
D
-
E
-
I
V
Q
G
F
A
V
-------------------------
37
HHSearch
53.29
19%
-109
- C1 -
1GES
1
GSHR_ECOLI
A:
[3-421]
--
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
A
S
I
N
R
A
A
M
Y
G
--
Q
K
C
A
L
I
E
A
K
E
L
G
GTC
V
N
VG
C
V
P
K
K
V
M
W
H
---------
A
A
Q
I
R
E
A
----
I
-
H
MYG--
P
DYGFDTTIN
K
F
N
W
-
E
T
L
I
A
S
R
T
A
Y
I
D
R
-------
I
---
H
----------
T
S
Y
E
N
V
L
G
K
---------------------
N
N
V
D
V
I
K
G
F
-
A
R
F
V
D
A
--
K
T
L
E
V
N
------
G
-
E
T
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
-
D
I
P
----
G
V
E
---
Y
G
I
D
S
D
G
F
F
A
L
---
P
-----
A
--
L
P
E
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
N
G
-
L
G
A
K
----
T
H
L
F
E
M
F
D
A
P
L
P
S
-
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
V
K
N
T
D
-------------------
G
-
S
-
L
T
L
E
L
E
D
G
R
S
-
E
T
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
IN
L
E
A
--
A
G
V
K
T
N
EK
G
---
Y
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
N
T
G
A
----------------------
V
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
F
N
N
K
PD
E
-
H
L
--
D
-
Y
S
N
I
P
T
V
V
--------------
F
S
H
P
-
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
-
Q
YGDDQ
V
---
K
V
Y
K
S
S
F
T
AMYTAV
T
----------
T
--
H
R
Q
P
--------------
C
R
M
K
L
V
C
V
G
S
E
E
K
I
V
G
I
H
G
I
---
G
-----
F
-
G
M
D
-
E
-
M
L
Q
G
F
A
V
-------------------------
23
HHSearch
53.03
18%
-109
- C1 -
1NHP
3
NAPE_ENTFA
A:
[1-405]
----
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
P
D
A
E
I
Q
W
Y
E
K
G
D
F
I
---
S
F
-----
L
S
A
G
M
Q
---------
L
-----
Y
----
L
-
E
-----
G
---------
K
V
K
D
-
V
N
----------
S
-------
V
---
R
----------
Y
M
T
G
E
K
M
E
S
---------------------
R
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
DLVSG
E
E
-
R
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
-
D
I
P
----
G
K
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
V
D
P
--
E
V
N
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
----
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
-
G
---------------------
R
-
V
Q
K
V
V
T
D
K
N
A
-
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
--
L
K
G
---
T
L
E
L
H
PN
G
---
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
------
K
Y
-----
N
PAD
T
E
V
-
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
--
K
-
P
F
P-
G
-
V
Q
G
S
S
G
L
A
--------------
V
F
D
Y
-
K
F
A
S
T
G
I
N
E
V
M
A
Q
K
-
L
G
K
E
T
K
A
V
--
T
-------------
V
V
E
DYLMDFN-
P
--
D
K
Q
K
--------------
A
W
F
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
-----
K
A
D
L
T
-
A
-
N
I
N
A
I
S
--------------------------
35
HHSearch
51.94
18%
-111
- C1 -
3O0H
3
?
A:
[24-440]
-
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
V
R
A
A
R
L
A
G
A
L
G
--
K
R
V
A
I
A
E
E
Y
R
I
G
GTC
V
I
RG
C
V
P
K
K
L
Y
F
Y
A
S
Q
Y
A
Q
E
F
S
K
-----
S
I
G
F
G
W
-
K
YAD--
P
---------
I
F
N
W
-
E
K
----------
L
-------
V
---
A
A
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
L
Q
N
---------------------
S
N
V
H
I
Y
E
-
S
R
A
V
F
V
D
E
H
T
L
E
L
S
V
T
------
G
-
E
R
I
S
A
E
K
I
L
I
A
T
G
A
K
I
V
S
N
--
I
K
----
G
S
D
---
L
C
L
T
S
N
E
I
F
D
L
E
--------
K
--
L
P
K
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
F
H
G
-
L
G
V
K
----
T
T
L
L
H
R
G
D
L
I
L
R
N
-
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
Q
S
T
-
E
-------------------
N
-
C
-
Y
N
V
V
L
T
N
G
Q
T
-
I
C
A
D
R
V
M
L
A
T
G
R
V
P
N
T
T
G
LG
L
E
R
--
A
G
V
K
V
N
EF
G
---
A
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
V
T
G
H
----------------------
I
Q
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
F
E
-----T
T
P
--
D
-
Y
D
L
I
T
T
A
V
--------------
F
S
Q
P
-
E
I
G
T
V
G
L
S
E
E
D
A
L
H
-
R
Y
K
R
V
-----
E
I
Y
R
----------
T
V
F
R
P
M
R
N
V
L
S
G
--
S
P
E
K
--------------
M
F
M
K
L
V
V
D
G
E
S
R
I
V
V
G
A
H
V
L
---
G
-----
E
-
N
A
G
-
E
-
I
A
Q
L
I
G
--------------------------