@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00656_CASP6_: (2014-09-14 )
AFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
Atome Classification :
(28 SA)
.........10........-20........30........40........50........60........70........80.-.-......90........100.......-110........120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......-.260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
AF
Y
K
R
EMF
D
P
A
E
K
Y
K
M
D
H
R-RR
G
I
A
L
I
F
NH
E
R
F
F
W
H
L
TLPERRGTCA
D
R
D
N
L
T
R
R
F
S
DLG
F
E
V
K
CFNDL
K
A
E
E
L
L
L
K
I
H
E
V
ST-V-SHADA
D
C
F
V
C
V
F
L
SHGEG
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
TGLFKGD
K
C
H
SLVGK
P
K
I
F
I
I
QACRGNQHDV
P
V
I
P
L
DVVDNQ
T
E
KLDTNITEVDA
A
S
V
Y
TLPAGA
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
SHRETVNGS
W
Y
I
Q
D
L
C
E
M
L
G
KYGSS
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
FCKD
P
S
AIGKKQV
P
C
F
A
S
M
-
L
T
K
K
L
HFFPKSN
33
PsiBlast_CBE
95.16
99%
-125
- C4 -
4N7M
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
Q
-------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
32
PsiBlast_CBE
94.76
99%
-121
- C4 -
4NBK
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
Q
-------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
31
PsiBlast_CBE
94.56
99%
-121
- C4 -
4NBL
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
--------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
35
PsiBlast_CBE
94.50
99%
-123
- C4 -
4N6G
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
Q
-------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
34
PsiBlast_CBE
94.22
99%
-125
- C4 -
4N7J
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
Q
-------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
4
PsiBlast_PDB
94.03
100%
-123
- C4 -
3OD5
1
CASP6_HUMAN
A:
[8-268]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
L
---------------------
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
25
PsiBlast_CBE
93.84
100%
-123
- C4 -
3S70
1
CASP6_HUMAN
C:
[8-268]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
L
----------------------
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
30
PsiBlast_CBE
93.71
99%
-126
- C4 -
4NBN
1
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
--------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
5
PsiBlast_PDB
93.60
100%
-122
- C4 -
3S70
1
CASP6_HUMAN
A:
[8-269]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
L
---------------------
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
S
-
36
PsiBlast_CBE
93.51
99%
-123
- C4 -
4N5D
2
CASP6_HUMAN
B:
[10-271]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
A
R
G
N
Q
-------------------
T
N
I
T
E
V
D
A
A
S
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
26
PsiBlast_CBE
92.53
100%
-122
- C4 -
3OD5
1
CASP6_HUMAN
B:
[8-268]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
L
---------------------
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
37
PsiBlast_CBE
91.21
94%
-122
- C4 -
4HVA
2
CASP6_HUMAN
B:
[7-254]
------
M
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
L
---------------------
V
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
17
PsiBlast_PDB
91.10
94%
-123
- C4 -
4HVA
2
CASP6_HUMAN
A:
[8-254]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
G
N
Q
H
D
V
P
V
I
P
-----------------------
Y
T
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
43
Fugue
78.25
44%
-114
- C4 -
1CP3
2
CASP3_HUMAN
A:
[35-277]
-----------
N
S
Y
K
M
D
Y
-P
E
M
G
L
C
I
I
I
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
M
R
D
V
S
K
E
D
--
H
S
K
R
S
S
F
V
C
V
L
L
S
H
G
E
E
G
I
I
F
G
T
N
-
G
P
-
V
D
L
K
K
I
T
N
F
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
I
Q
A
C
R
G
T
E
L
D
--------------------
C
G
I
E
H
----
K
I
P
V
D
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
S
W
F
I
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
F
M
H
I
L
T
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
P
C
I
V
S
-M
L
T
K
E
L
Y
F
Y
H
---
61
HHSearch
77.93
39%
-119
* C4 *
4JR2
1
?
A:
[3-249]
---------
A
T
Y
Q
Y
N
M
N
F
E
-
K
L
G
K
C
I
I
I
N
N
K
N
F
D
K
V
T
G
M
G
V
R
N
G
T
D
K
D
A
E
A
L
F
K
C
F
R
S
L
G
F
D
V
I
V
Y
N
D
C
S
C
A
K
M
Q
D
L
L
K
K
A
S
E
-
E
-
D
H
T
N
A
A
C
F
A
C
I
L
L
S
H
G
E
E
N
V
I
Y
G
K
D
G
-
V
-
T
P
I
K
D
L
T
A
H
F
R
G
D
R
C
K
T
L
L
E
K
P
K
L
F
F
I
Q
A
C
R
G
---------------------------------
K
I
P
V
E
A
D
F
L
F
A
Y
S
T
V
P
G
Y
Y
S
W
R
S
P
G
R
G
S
W
F
V
Q
A
L
C
S
I
L
E
E
H
G
K
D
L
E
I
M
Q
I
L
T
R
V
N
D
R
V
A
R
H
F
E
S
Q
S
D
D
P
H
F
H
E
K
K
Q
I
P
C
V
V
S
M
-
L
T
K
E
L
Y
F
S
----
20
PsiBlast_PDB
76.11
41%
-112
- C4 -
4EHH
1
?
A:
[37-276]
-------------
Y
K
M
D
Y
P
-
E
M
G
L
C
I
I
I
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
M
R
D
V
S
K
-
E
-
D
H
S
K
R
S
S
F
V
C
V
L
L
S
H
G
E
A
G
I
I
F
G
T
N
G
-
P
-
V
D
L
K
K
I
T
N
F
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
I
Q
A
C
R
G
T
E
L
D
C
G
I
E
T
-----------------------
H
K
I
P
V
E
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
S
W
F
I
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
F
M
H
I
L
T
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
P
C
I
V
S
M
-
L
T
K
E
L
Y
F
Y
----
57
HHSearch
73.81
38%
-113
- C4 -
1F1J
2
CASP7_HUMAN
A:
[60-304]
-----------
Y
Q
Y
N
M
N
F
E
-
K
L
G
K
C
I
I
I
N
N
K
N
F
D
K
V
T
G
M
G
V
R
N
G
T
D
K
D
A
E
A
L
F
K
C
F
R
S
L
G
F
D
V
I
V
Y
N
D
C
S
C
A
K
M
Q
D
L
L
K
K
A
S
E
-
E
-
D
H
T
N
A
A
C
F
A
C
I
L
L
S
H
G
E
E
N
V
I
Y
G
K
D
G
-
V
-
T
P
I
K
D
L
T
A
H
F
R
G
D
R
S
K
T
L
L
E
K
P
K
L
F
F
I
Q
A
C
R
G
T
E
L
D
D
G
I
Q
-------------------------
K
I
P
V
E
A
D
F
L
F
A
Y
S
T
V
P
G
Y
Y
S
W
R
S
P
G
R
G
S
W
F
V
Q
A
L
C
S
I
L
E
E
H
G
K
D
L
E
I
M
Q
I
L
T
R
V
N
D
R
V
A
R
H
F
E
S
Q
S
D
D
P
H
F
H
E
K
K
Q
I
P
C
V
V
S
M
-
L
T
K
E
L
Y
F
S
----
54
HHSearch
69.30
43%
-110
- C4 -
2J32
2
CASP3_HUMAN
A:
[6-249]
----------
D
N
S
Y
K
M
D
Y
P
-
E
M
G
L
C
I
I
I
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
M
R
D
V
S
K
-
E
-
D
H
S
K
R
S
S
F
V
C
V
L
L
S
H
G
E
E
G
I
I
F
G
T
N
G
-
P
-
V
D
L
K
K
I
T
N
F
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
I
Q
A
C
R
G
T
E
L
D
C
G
I
A
T
-----------------------
H
K
I
P
V
E
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
S
W
F
I
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
F
M
H
I
L
T
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
P
C
I
V
S
M
-
L
T
K
E
L
Y
F
Y
H
---
52
HHSearch
69.30
42%
-109
- C4 -
4EHD
1
CASP3_HUMAN
A:
[29-277]
-----
S
G
I
S
L
D
N
S
Y
K
M
D
Y
P
-
E
M
G
L
C
I
I
I
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
M
R
D
V
S
K
-
E
-
D
H
S
K
R
S
S
F
V
C
V
L
L
S
H
G
E
E
G
I
I
F
G
T
N
G
-
P
-
V
D
L
K
K
I
T
N
F
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
I
Q
A
C
R
G
T
E
L
D
C
G
I
E
T
-----------------------
H
K
I
P
V
E
A
D
F
L
Y
A
C
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
S
W
F
I
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
F
M
H
I
L
T
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
P
C
I
V
S
M
-
L
T
K
E
L
Y
F
Y
H
---
39
PsiBlast_CBE
55.58
100%
-121
- C4 -
3QNW
1
?
C:
[8-140]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
-----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.17
100%
-119
- C4 -
3QNW
1
?
A:
[8-141]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
R
----------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
54.86
100%
-120
- C4 -
3QNW
1
?
G:
[8-140]
-------
F
D
P
A
E
K
Y
K
M
D
H
R
-
R
R
G
I
A
L
I
F
N
H
E
R
F
F
W
H
L
T
L
P
E
R
R
G
T
C
A
D
R
D
N
L
T
R
R
F
S
D
L
G
F
E
V
K
C
F
N
D
L
K
A
E
E
L
L
L
K
I
H
E
V
S
T
-
V
-
S
H
A
D
A
D
C
F
V
C
V
F
L
S
H
G
E
G
N
H
I
Y
A
Y
D
A
-
K
-
I
E
I
Q
T
L
T
G
L
F
K
G
D
K
C
H
S
L
V
G
K
P
K
I
F
I
I
Q
A
C
-----------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
53.32
39%
-124
- C4 -
2DKO
1
CASP3_HUMAN
A:
[3-145]
-------
I
S
L
D
N
S
Y
K
M
D
Y
P
-
E
M
G
L
C
I
I
I
N
N
K
N
F
H
K
S
T
G
M
T
S
R
S
G
T
D
V
D
A
A
N
L
R
E
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
T
R
E
E
I
V
E
L
M
R
D
V
S
K
-
E
-
D
H
S
K
R
S
S
F
V
C
V
L
L
S
H
G
E
E
G
I
I
F
G
T
N
G
-
P
-
V
D
L
K
K
I
T
N
F
F
R
G
D
R
C
R
S
L
T
G
K
P
K
L
F
I
I
Q
A
C
R
G
T
E
L
D
C
G
I
E
-------------------------------------------------------------------------------------------------------------------------
68
HHSearch
48.51
34%
-114
- C4 -
1PYO
1
CASP2_HUMAN
A:
[23-166]
----------
Q
L
A
Y
R
L
Q
S
R
-
P
R
G
L
A
L
V
L
S
N
V
H
F
T
G
E
K
E
L
E
F
R
S
G
G
D
V
D
H
S
T
L
V
T
L
F
K
L
L
G
Y
D
V
H
V
L
C
D
Q
T
A
Q
E
M
Q
E
K
L
Q
N
F
A
Q
-
L
P
A
H
R
V
T
D
S
C
I
V
A
L
L
S
H
G
V
E
G
A
I
Y
G
V
D
G
-
K
L
L
Q
L
Q
E
V
F
Q
L
F
D
N
A
N
C
P
S
L
Q
N
K
P
K
M
F
F
I
Q
A
C
R
G
D
E
T
D
R
G
V
D
Q
Q
-----------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
41.72
100%
-106
- C4 -
3QNW
1
?
D:
[7-98]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
42
PsiBlast_CBE
41.40
100%
-105
- C4 -
3QNW
1
?
B:
[7-99]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
F
C
K
D
P
S
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
S
-
40
PsiBlast_CBE
39.22
100%
-103
- C4 -
3QNW
1
?
H:
[9-98]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
D
F
L
M
C
Y
S
V
A
E
G
Y
Y
S
H
R
E
T
V
N
G
S
W
Y
I
Q
D
L
C
E
M
L
G
K
Y
G
S
S
L
E
F
T
E
L
L
T
L
V
N
R
K
V
S
Q
R
R
V
D
------
A
I
G
K
K
Q
V
P
C
F
A
S
M
-
L
T
K
K
L
H
F
F
P
K
--
70
HHSearch
31.77
48%
-71
- C4 -
2XZD
1
?
B:
[9-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
H
K
I
P
V
E
A
D
F
L
Y
A
Y
S
T
A
P
G
Y
Y
S
W
R
N
S
K
D
G
S
W
F
I
Q
S
L
C
A
M
L
K
Q
Y
A
D
K
L
E
F
M
H
I
L
T
R
V
N
R
K
V
A
T
E
F
E
S
F
S
F
D
A
T
F
H
A
K
K
Q
I
P
C
I
V
S
M
-
L
T
K
E
L
Y
F
Y
H
---