@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0556: (2015-12-02 )
MDENINFETDTTFALIKEAQRRKYKVFAYAPSNLALKLNQPIALAQKVSVDDCNFTSKEDVVINLNEMDIIFIRQDPPFDMRYITTTYILEKTRALVINNPTEMRNCPEKLITSLFPELIPPTLITENISMIRDFYHDYRGIILKPLYSYGGNDVIRIQNENSIQVVVELMITKYKCPVIAQAFCKNVNKDKRILLLDGQPIGVMKRVPRVSGEIRTNLRLGASFEPVEMNDRDNEICNKIGPELKKRGLIFVGIDIVDDFLLEINITSPTGVVYINKLYNTSLEKDLWNTFEEKASSHISQPSL
Atome Classification :
(20 SA)
-------..--.......10........20........30......-.-.-40....-...-..-50--..-----..---.--....-60........70........---80--..--.-......90...---....-.-100........110......-----------..----120-..--.....130.-......140--........-150......-.-160...-....170---.-----.----------.....180.....-.-.-190......---.---.200-.-.--.-...-.210.......--.220..--.--...-----.-230.----.-----..-----.....240.......---250.........----260---.........270-.-.----.....280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MD--ENINFET
D
T
T
F
A
L
I
K
E
A
QRR
K
Y
K
V
F
A
YAPS
N
L
A
L
K
-L-N-Q-P
I
A
L
-
A
Q
K-VS-V---DD-----CN---F--TSKE-
D
V
V
I
N
LNE
M
D
I
I
F
I
RQDPPF---
D
---
M
R
--
Y
-
I
T
T
T
Y
I
L
EK
T
R
---
A
L
V
I-N-N
P
-
T
E
M
R
N
C
P
E
K
-
L
I
T
S
L
F
P
-----------
E
L----I
P
P
-
T
L
--
I
T
E
N
I
S
M
I
R
-
D
F
Y
H
D
Y
R
-
G
--
I
I
L
K
P
L
Y
S-YGGN
D
V
I
R
I-Q-NEN
S
I
Q
-
V
V
V
E
L
M
I
---T-----K----------YKC
P
V
I
A
Q
A
F
C
K
N-V-N-K-D
K
R
I
L
L
L---D---GQP
I
-
G
-
V
--
M
-
K
RV-PRV-S
G
E
I
R
T
N
--
L
RLGAS--F--EPV-----E-M--N----D-----R
D
-----
N
E
I
C
N
KI
G
P
E
L
K
KR
G
---
L
--
I
F
V
G
I
D
I
VD----D-----
F
L
L
E
I
N
ITSPT
G
-
V
-
V
----
Y
I
N
K
L
YNTSL
E
K
D
L
W
N
T
F
E
E
K
A
S
S
HISQPSL
1
PsiBlast_PDB
97.73
35%
-97
- C3 -
1GSA
5
GSHB_ECOLI
A:
[13-312]
------------
N
I
N
I
K
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
---
K
Q
NYEEW
F
S
---
F
--
V
G
E
Q
-
D
--
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
--
F
-
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
G
-
M
G
G
A
S
I
F
R
V
K
E
-
G
D
P
N
L
G
-
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
-
I
K
D
-
G
-
D
K
R
V
L
V
V
---
D
---
G
E
P
V
-
P
Y
C
--
L
-
A
R
I
-
P
Q
--
G
G
E
T
R
G
N
--
L
A
A
G
G
R
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
--------
8
HHSearch
94.94
35%
-96
- C3 -
1GSA
5
GSHB_ECOLI
A:
[18-314]
-----------------
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
K
QN
Y
E
-----
E
W
---
F
--
S
F
V
G
E
Q
-
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
F
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
---
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
G
-
M
G
G
A
S
I
F
R
V
-
K
-
E
G
D
P
N
L
G
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
I
K
-
D
-
G
-
D
K
R
V
L
V
V
---
D
---
G
E
P
V
-
P
Y
C
--
L
-
A
R
I
-
P
Q
--
G
G
E
T
R
G
N
--
L
A
A
G
G
R
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
--------
4
PsiBlast_PDB
94.71
34%
-109
- C3 -
1GLV
-
GSHB_ECOLI
A:
[13-312]
------------
N
I
N
I
K
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
---
K
Q
NYEEW
F
S
---
F
--
V
G
E
Q
-
D
--
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
--
F
-
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
-----
A
S
I
F
R
V
K
E
-
G
D
P
N
L
G
-
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
-
I
K
D
-
G
-
D
K
R
V
L
V
V
---
D
---
G
E
P
-----------
V
-
P
Y
C
----------
L
A
R
G
G
G
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
Q
Q
------
2
PsiBlast_PDB
94.53
35%
-114
- C3 -
1GSH
-
GSHB_ECOLI
A:
[13-312]
------------
N
I
N
I
K
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
---
K
Q
NYEEW
F
S
---
F
--
V
G
E
Q
-
D
--
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
--
F
-
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
-----
A
S
I
F
R
V
K
E
-
G
D
P
N
L
G
-
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
-
I
K
D
-
G
-
D
K
R
V
L
V
V
---
D
---
G
E
P
V
-
P
Y
C
--
L
-
A
---------------------
R
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
Q
Q
------
3
PsiBlast_PDB
94.22
35%
-116
- C3 -
2GLT
-
GSHB_ECOLI
A:
[13-312]
------------
N
I
N
I
K
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
---
K
Q
NYEEW
F
S
---
F
--
V
G
E
Q
-
D
--
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
--
F
-
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
-----
A
S
I
F
R
V
K
E
-
G
D
P
N
L
G
-
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
-
I
K
D
-
G
-
D
K
R
V
L
V
V
---
D
---
G
E
P
V
-
P
Y
C
--
L
-
A
---------------------
R
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
Q
Q
------
28
Fugue
76.13
37%
-104
- C3 -
1GSA
5
?
?:
[123-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
G
-
M
G
G
A
S
I
F
R
V
-
K
E
G
D
P
N
L
G
-
V
I
A
E
T
L
T
---
E
-----
H
----------
G
T
R
Y
C
M
A
Q
N
Y
L
P
A
-
I
-
K
-
D
G
D
K
R
V
L
V
V
---
D
---
G
E
P
V
P
Y
-
C
--
L
-
A
R
I
-
P
Q
--
G
G
E
T
R
G
N
--
L
A
A
G
G
R
--
G
--
E
P
R
-----
P
-
L
--
T
----
E
-----
S
D
-----
W
K
I
A
R
Q
I
G
P
T
L
K
E
K
G
---
L
--
I
F
V
G
L
D
I
I
G
----
D
-----
R
L
T
E
I
N
V
T
S
P
T
C
-
I
-
R
----
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
--------
10
HHSearch
67.80
20%
-88
- C3 -
3VPB
5
ARGX_SULTO
A:
[12-281]
------------------
Q
E
E
K
L
I
A
K
A
L
E
E
N
K
V
Q
Y
D
I
I
N
V
A
Q
E
P
L
P
-
F
-------------------------------------------
N
K
A
L
G
R
Y
D
V
A
I
I
R
P
V
S
M
Y
--------
R
--
A
-
L
Y
S
S
A
V
L
E
A
A
G
---
V
H
T
I
-
N
-
S
S
-
D
V
I
N
V
C
G
D
K
-
I
L
T
Y
S
K
L
Y
R
E
G-------
I
P
----
I
P
D
-
S
I
--
I
A
L
S
A
E
A
A
L
-
K
A
Y
E
Q
R
G
F
P
--
L
I
D
K
P
P
I
G
-
S
W
G
R
L
V
S
L
I
-
R
-
D
V
F
E
G
K
-
T
I
I
E
H
R
E
L
MG
N
-----
S
----------
A
L
K
A
H
I
V
Q
E
Y
I
Q
Y
-
K
-
G
-
R
-
D
I
R
C
I
A
I
---
G
---
E
E
L
L
-
G
-
C
--
Y
-
A
R
N
-
I
P
--
P
N
E
W
R
A
N
--
V
A
L
G
G
T
--
P
--
S
N
I
-----
E
-
V
--
D
----
E
-----
K
L
-----
K
E
T
V
V
K
A
V
S
I
V
---
H
---
G
--
E
F
V
S
I
D
I
L
E
----
H
PNKGY
V
V
N
E
L
N
D
V
-
P
-
E
-
F
-
K
----
G
F
M
V
A
T
N
I
N
V
A
Q
K
L
V
E
Y
I
K
E
N
Y
S
--------
9
HHSearch
64.06
15%
-89
- C3 -
3VPD
3
LYSX_THET8
A:
[10-280]
-----------------
R
P
D
E
R
M
L
F
E
R
A
E
A
L
G
L
P
Y
K
K
V
Y
V
P
A
L
P
M
V
-
L
-
G
-
E
-------------------------
R
-------------
P
E
A
L
E
G
V
T
V
A
L
E
R
C
V
S
Q
S
--------
R
--
G
-
L
A
A
A
R
Y
L
T
A
L
G
---
I
P
V
V
-
N
-
R
P
-
E
V
I
E
A
C
G
D
K
-
W
A
T
S
V
A
L
A
K
A
G-------
L
P
----
Q
P
K
-
T
A
--
L
A
T
D
R
E
E
A
L
-
R
L
M
E
A
F
G
Y
P
--
V
V
L
K
P
V
I
G
-
S
W
G
R
L
L
A
K
V
-
T
-
D
R
A
A
A
E
-
A
L
L
E
H
K
E
---
V
LGG--
F
----------
Q
H
Q
L
F
Y
I
Q
E
Y
V
E
K
-
P
-
G
-
R
-
D
I
R
V
F
V
V
---
G
---
E
R
A
I
-
A
-
A
--
I
-
Y
R
R
-
S
----
A
H
W
I
T
N
--
T
A
R
G
G
Q
--
A
--
E
N
C
-----
P
-
L
--
T
----
E
-----
E
I
-----
A
R
L
S
V
G
A
A
E
A
V
---
G
---
G
--
G
V
V
A
V
D
L
F
E
----
S
ER
G
L
-
L
V
N
E
V
N
H
T
M
-
E
--
F
-
K
----
N
S
V
H
T
T
G
V
D
I
P
G
E
I
L
R
Y
A
W
E
V
A
R
G
-------
31
Fugue
63.43
14%
-77
- C3 -
4IWX
7
RIMK_ECOLI
A:
[19-312]
S
H
M
K
I
A
I
L
S
--
R
D
G
T
L
Y
S
C
K
R
L
R
E
A
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
-
P
-
A
-
A
-
S
----------------
S
-----
I
H
---
Y
--
K
G
R
K
------
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
---
T
---
F
Y
--
G
-
T
A
A
L
R
Q
F
E
M
L
G
---
S
Y
P
L
-
N
-
E
S
-
V
A
I
A
R
A
R
D
K
-
L
R
S
M
Q
L
L
-----------
A
R
Q
GID
L
P
V
-
T
G
--
I
A
H
S
P
D
D
T
S
-
D
L
I
D
M
V
G
-
G
A
P
L
V
V
K
L
V
E
G
-
T
Q
G
I
G
V
V
L
A
-
E
-
T
R
Q
A
A
E
-
S
V
I
D
A
F
R
---
G
----------------
L
N
A
H
I
L
V
Q
E
Y
I
K
E
-
A
-
Q
G
C
-
D
I
R
C
L
V
V
---
G
---
D
E
V
V
-
A
-
A
--
I
-
E
R
R
-
A
K
--
E
G
D
F
R
S
N
--
L
H
R
G
G
A
--
A
--
S
V
A
-----
S
-
I
--
T
----
P
-----
Q
E
-----
R
E
I
A
I
K
A
A
R
T
M
---
A
---
L
--
D
V
A
G
V
D
I
L
R
A
NRG
P
-----
L
V
M
E
V
N
--
A
S
P
G
-
L
-
E
----
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
R
H
A
T
T
-------
29
Fugue
51.98
36%
-108
- C3 -
1GSA
1
?
?:
[1-122]
M
I
K
L
G
I
V
M
D
PI
A
N
I
N
I
K
K
D
S
S
F
A
M
L
L
E
A
Q
R
R
G
Y
E
L
H
Y
M
E
M
G
D
L
Y
L
I
-
N
-
G
-
E
-
A
R
A
H
-
T
R
T
-
L
N
-
V
---
K
Q
-----
N
Y
EEW
F
--
S
F
V
G
-
E
Q
D
L
P
L
A
D
L
D
V
I
L
M
R
K
D
P
P
F
---
D
---
T
E
--
F
-
I
Y
A
T
Y
I
L
E
R
A
E
E
K
G
T
L
I
V
-
N
-
K
P
-
Q
S
L
R
D
C
N
E
K
-
L
F
T
A
W
F
S
-----------
D
L
----
T
P
E
-
T
L
--
V
T
R
N
K
A
Q
L
K
-
A
F
W
E
K
H
S
-
D
--
I
I
L
K
P
L
D
G
-
M
G
G
A
S
I
F
R
V
-
K
-
E
G
D
P
N
L
-
G
V
I
A
E
T
L
---
T
-----
E
----------
H
G
T
R
Y
C
M
A
Q
N
Y
L
P
-
A
-
I
-
K
-
D
G
D
K
R
V
L
---
V
---
V
D
G
E
-
P
-
V
--
P
-
Y
C
L
-
A
R
I
-
P
Q
G
G
E
T
R
--
G
N
L
A
A
G
--
G
--
R
G
E
-----
P
-
R
--
P
----
L
-----
T
E
-----
S
D
W
K
I
A
R
Q
I
G
P
T
L
K
E
---
K
--
G
L
I
F
V
G
L
D
I
----
I
-----
G
D
R
L
T
E
I
N
V
T
S
P
-
T
-
C
----
I
R
E
I
E
A
E
F
P
V
S
I
T
G
M
L
M
D
A
I
E
A
R
L
Q
------
15
HHSearch
51.42
16%
-79
- C3 -
1PK8
3
SYN1_RAT
A:
[177-418]
---------------------------------------------------------------------------------------------
R
S
L
K
P
D
F
V
L
I
R
Q
H
A
F
S
---
M
ARN
G
D
--
Y
-
R
S
L
V
I
G
L
Q
Y
A
G
---
I
P
S
V
-
N
-
S
L
-
H
S
V
Y
N
F
C
D
K
-
P
W
V
F
A
Q
M
V
R
L
H
K
K
LGTEE
F
P
----
L
I
D
-
Q
T
--
F
Y
P
N
H
---
K
-
E
M
L
S
S
T
T
Y
P
--
V
V
V
K
M
G
H
A
-
H
S
G
M
G
K
V
K
V
-
D
-
N
Q
H
D
F
Q
-
D
I
A
S
V
V
A
---
L
----------------
T
K
T
Y
A
T
A
E
P
F
I
D
A
-
K
---
Y
-
D
V
R
V
Q
K
I
---
G
---
Q
N
Y
K
-
A
-
Y
--
M
--
R
T
-
S
V
--
S
G
N
W
K
T
N
--
T
G
S
-
A
M
--
L
--
E
Q
I
-----
A
-
M
--
S
----
D
-----
R
Y
-----
K
L
W
V
D
T
C
S
E
I
F
---
G
G--
L
--
D
I
C
A
V
E
A
L
H
----
G
KDG
R
D
H
I
I
E
V
V
G
S
S
M
P
L
-
I
-
G
----
D
H
Q
D
E
D
K
Q
L
I
V
E
L
V
V
N
K
M
T
Q
A
----------
21
HHSearch
50.45
13%
-94
- C3 -
3R5X
2
DDL_BACAN
A:
[24-298]
--------------------
G
N
E
M
I
A
N
L
D
K
N
K
Y
E
I
V
P
I
T
L
N
E
K
M
D
--------------------------------
L
-------------
I
E
K
A
K
D
I
D
F
A
L
L
A
L
H
G
K
Y
---
G
---
E
---
D
-
G
T
V
Q
G
T
L
E
S
L
G
---
I
P
Y
S
-
G
-
S
N
M
L
S
S
G
I
C
M
D
K
-
N
I
S
K
K
I
L
R
Y
E
G-------
I
E
----
T
P
D
-
W
I
--
E
L
T
K
M
E
D
L
N
F
D
E
L
D
K
L
G
F
P
--
L
V
V
K
P
N
S
-----
V
G
V
K
I
V
-
Y
-
D
K
D
E
L
I
-
S
M
L
E
T
V
F
---
E
----------------
W
D
S
E
V
V
I
E
K
Y
I
K
G
-
E
-----
E
I
T
C
S
I
F
---
D
---
G
K
Q
L
-
P
-
I
--
I
S
I
R
H
-
A
---
A
E
F
F
D
Y
N
A
K
Y
D
D
A
S
T
--
I
E
-
E
V
I
-----
E
-
L
--
P
A
E
L
K
E
-----
R
V
-----
N
K
A
S
L
A
C
Y
K
A
L
---
K
C--
S
--
V
Y
A
R
V
D
M
M
V
----
K
DG
I
P
-
Y
V
M
E
V
N
T
L
P
G
M
T
-
Q
-
A
S
L
L
P
K
S
A
D
A
A
G
I
H
Y
S
K
L
L
-
D
M
I
I
E
T
S
L
R
V
R
K
E
E
G
-
11
HHSearch
50.06
15%
-78
- C3 -
2P0A
12
SYN3_HUMAN
A:
[33-324]
----------------------
K
Y
F
H
G
K
K
V
N
G
E
I
E
I
R
V
E
Q
A
E
F
S
E
L
N
L
-
A
-
A
-
Y
V
T
G
-
G
C
M
-
V
D
-
M
----
Q
----------------------
R
S
F
K
P
D
F
I
L
V
R
Q
H
A
Y
S
MAL
G
---
E
D
--
Y
-
R
S
L
V
I
G
L
Q
Y
G
G
---
L
P
A
V
-
N
-
S
L
-
Y
S
V
Y
N
F
C
S
K
P
W
V
F
S
Q
L
I
K
I
F
H
S
LGPEK-
F
P
----
L
V
E
-
Q
T
--
F
F
P
N
H
K
P
----
M
V
T
A
P
H
F
P
--
V
V
V
K
L
G
H
A
-
H
A
G
M
G
K
I
K
V
-
E
-
N
Q
L
D
F
Q
-
D
I
T
S
V
V
A
---
M
----------------
A
K
T
Y
A
T
T
E
A
F
I
D
S
---
K
-
Y
-
D
I
R
I
Q
K
I
---
G
---
S
N
Y
K
-
A
-
Y
--
M
--
R
T
-
S
I
--
S
G
N
W
K
A
N
--
T
G
S
-
A
M
--
L
--
E
Q
V
-----
A
-
M
--
T
----
E
-----
R
Y
-----
R
L
W
V
D
S
C
S
E
M
F
---
G
G--
L
--
D
I
C
A
V
K
A
V
H
----
S
KDG
R
D
Y
I
I
E
V
M
D
S
S
M
P
L
-
I
-
G
----
E
H
V
E
E
D
R
Q
L
M
A
D
L
V
V
S
K
M
S
Q
L
P
---------
27
HHSearch
49.04
14%
-80
* C3 *
3ORQ
3
?
A:
[22-303]
------------------
Q
L
G
K
M
M
A
Q
S
A
Q
K
M
G
Y
K
V
V
V
L
D
P
S
E
D
C
P
C
-
R
-
Y
---
V
A
H
E
-
F
I
Q
-
A
K
-
Y
D--
D
E
-----
K
A
---
L
--
N
------
Q
-
L
G
Q
K
C
D
V
I
T
Y
E
F
E
N
I
S
-----------
A
-
Q
Q
L
K
L
L
C
E
K
Y
N
---
I
P
---
Q
-
G
Y
-
Q
A
I
Q
L
L
Q
D
R
-
L
T
E
K
E
T
L
K
S
A
G-------
T
K
----
V
V
P
-
F
I
--
S
V
K
E
S
T
D
I
D
-
K
A
I
E
T
L
G
Y
P
--
F
I
V
K
T
R
F
G
G
Y
D
G
K
G
Q
V
L
I
-
N
-
N
E
K
D
L
Q
-
E
G
F
K
L
I
---------------------
E
T
S
E
C
V
A
E
K
Y
L
N
I
K
K
-----
E
V
S
L
T
V
T
---
R
G
N
N
N
Q
I
T
-
F
-
F
P
-
L
-
Q
E
N
-
E
------
H
R
N
Q
--
I
L
-
F
K
T
--
I
--
V
P
A
-----
R
-
I
DK
T
----
A
-----
E
A
-----
K
E
Q
V
N
K
I
I
Q
S
I
---
H
F--
I
--
G
T
F
T
V
E
F
F
I
----
D
SNN
Q
L
Y
V
N
E
I
A
P
R
P
H
N
S
-
G
-
H
----
Y
S
I
E
A
C
D
Y
S
Q
F
D
T
H
I
L
A
V
T
G
Q
S
L
P
N
S
I
E
L
L
K
19
HHSearch
48.70
13%
-77
- C3 -
3VOT
7
?
A:
[15-321]
------------------
K
H
L
P
F
I
F
E
E
A
E
R
L
G
L
K
V
T
F
F
Y
N
S
A
E
D
F
P
-
G
-
N
L
P
-
A
V
E
R
-
C
V
P
-
L
P
L
F
ED-
E
E
-----
A
A
---
M
--
D
V
V
R
-
Q
-
T
F
V
E
F
P
F
D
G
V
M
T
L
F
E
P
A
L
-------------
P
F
T
A
K
A
A
E
A
L
N
---
L
P
G
--
L
-
P
F
-
T
T
M
E
N
C
R
N
K
-
N
K
T
R
S
I
L
Q
Q
N
G-------
L
N
----
T
P
V
-
F
H
--
E
F
H
T
L
A
D
L
E
-
N
--
R
K
L
S
Y
P
--
L
V
V
K
P
V
N
------
G
V
V
R
V
-
D
-
D
R
K
E
L
E
-
E
A
V
R
K
V
E
---
A
-----
V
N
Q
RD
L
N
R
F
V
H
G
K
T
G
I
V
A
E
Q
F
I
D
G
-
P
-
E
-
F
-
A
I
E
T
L
S
I
---
Q
---
G
N
V
H
-
V
-
L
S
-
I
-
G
Y
K
G
N
S
--
K
G
P
F
-----
F
E
E
G
V
Y
--
I
--
A
P
A
-----
Q
-
L
--
K
E
E
T
R
L
-----
A
I
-----
V
K
E
V
T
G
A
V
S
A
L
---
G
---
I
HQ
G
P
A
H
T
E
L
R
L
----
D
KDG
T
P
Y
V
I
E
V
G
A
R
I
G
G
S
-
G
-
V
S
H
Y
-
I
V
K
E
S
T
G
I
N
F
M
Q
L
V
L
Q
N
A
L
K
P
L
E
S
S
E
F
E
G
E
I
22
HHSearch
47.95
12%
-74
- C3 -
1ULZ
-
?
A:
[11-320]
-----------------
G
E
I
A
V
R
I
I
R
A
C
K
E
L
G
I
P
T
V
A
I
Y
N
E
V
E
S
T
A
-
R
H
V
-
K
-
L
A
D
E
-
A
Y
M
-
I
G
-
T
D
P
-
L
D
-----
T
Y
---
L
N
K
Q
R
I
I
-
N
-
L
A
L
E
V
G
A
D
A
I
H
P
G
Y
G
F
L
A
---
E
-------
N
-
A
E
F
A
K
M
C
E
E
A
G
---
I
T
F
I
-
G
P
H
W
-
K
V
I
E
L
M
G
D
K
-
A
R
S
K
E
V
M
K
K
A
G-------
V
P
----
V
V
P
-
G
S
DG
V
L
K
S
L
E
E
A
K
-
A
L
A
R
E
I
G
Y
P
--
V
L
L
K
A
T
A
G
-
G
G
G
R
G
I
R
I
C
-
R
-
N
E
E
E
L
V
-
K
N
Y
E
Q
A
S
---
R
E
A
E
K
A
F
----------
G
R
G
D
L
L
L
E
K
F
I
E
N
-
P
---
K
-
H
I
E
Y
Q
V
L
G
D
K
H
---
G
N
V
I
-
H
-
L
--
G
-
E
R
D
-
C
S
--
I
Q
R
R
N
Q
K
--
L
V
E
I
A
P
--
S
LI
L
T
P
-----
E
-
K
--
R
----
E
-----
Y
Y
-----
G
N
I
V
T
K
A
A
K
E
I
---
G
Y--
Y
--
N
A
G
T
M
E
F
I
A
----
D
QEG
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
-
H
-
P
----
V
S
E
M
V
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
E
P
L
T
I
K
Q
E
D
V
K
18
HHSearch
46.24
11%
-74
- C3 -
2YRX
2
?
A:
[34-338]
--------------------
H
A
I
A
W
K
A
A
Q
S
P
L
V
G
K
L
Y
V
A
P
G
N
P
G
I
A
-
D
V
A
-
E
L
V
H
I
D
-
E
L
D
--------
I
E
-----
A
L
---
V
--
Q
------
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
-----------
A
-
S
G
I
V
D
R
F
M
A
E
G
---
L
R
I
F
G
P
-
S
Q
-
R
A
A
L
I
E
G
S
K
-
A
F
A
K
E
L
M
K
K
Y
G-------
I
P
----
T
A
D
-
H
A
--
A
F
T
S
Y
E
E
A
K
-
A
Y
I
E
Q
K
G
A
P
--
I
V
I
K
A
D
-----
G
K
G
V
T
V
A
-
Q
-
T
V
E
E
A
L
-
A
A
A
K
A
A
L
---
V
DGQFG
T
----------
A
G
S
Q
V
V
I
E
E
Y
L
E
G
-
E
-
E
-
F
-
S
F
M
A
F
V
N
---
G
---
E
K
V
Y
-
P
-
L
A-
I
-
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
--
T
G
G
M
G
A
--
Y
--
S
P
V
-----
P
Q
I
--
S
----
D
E
M
M
D
A
A
L
-----
E
A
I
L
R
P
A
A
K
A
L
A
A
E
G
RPF
L
--
G
V
L
Y
A
G
L
M
A
----
T
ANGP-
K
V
I
E
F
N
A
R
F
G
D
P
-
E
A
Q
----
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
D
G
K
E
L
E
L
E
W
T
D
E
A
26
HHSearch
46.04
13%
-64
- C3 -
1A9X
-
CARB_ECOLI
A:
[580-873]
------------------
Y
C
C
V
H
A
S
L
A
L
R
E
D
G
Y
E
T
I
M
V
N
C
N
P
E
T
V
S
-
T
-
D
-
Y
D
T
S
D
R
-
L
Y
F
-
E
------
P
V
-----
T
L
---
E
--
D
V
L
E
---
I
V
R
I
E
K
P
K
G
V
I
V
Q
Y
G
G
Q
T
---
P
---------
L
K
L
A
R
A
L
E
A
A
G
---
V
P
V
I
G
T
-
S
P
-
D
A
I
D
R
A
E
D
R
-
E
R
F
Q
H
A
V
E
R
L
K-------
L
K
----
Q
P
A
-
N
A
--
T
V
T
A
I
E
M
A
V
-
E
K
A
K
E
I
G
Y
P
--
L
V
V
R
A
--------
A
M
E
I
V
-
Y
-
D
E
A
D
L
R
-
R
Y
F
Q
T
A
V
-------------------------
L
L
D
H
F
L
D
D
A
V
-
E
-
V
-
D
V
D
A
I
C
D
---
G
---
E
M
V
L
-
I
-
G
G
I
M
-
E
H
I
-
E
Q
---
A
----
G
--
V
H
S
G
D
S
A
C
S
--
L
P
A
YTLS
Q
E
-
I
--
Q
----
D
-----
V
M
-----
R
Q
Q
V
Q
K
L
A
F
E
L
---
Q
V--
R
--
G
L
M
N
V
Q
F
A
V
----
K
NN
E
V
-
Y
L
I
E
V
N
P
R
A
A
R
T
-
V
-
P
----
F
V
S
K
A
T
G
V
P
L
A
K
V
A
A
R
V
M
A
G
K
S
L
A
E
Q
G
V
T
K
E
12
HHSearch
45.74
12%
-75
- C3 -
2IP4
1
?
A:
[17-312]
------------------------
W
K
A
A
Q
S
P
R
V
K
R
L
Y
A
A
P
G
N
A
G
M
E
-
A
-----
L
A
E
L
-
V
P
W
N
G
D
-----
V
E
-----
A
L
---
A
--
D
------
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
-----------
V
-
E
G
I
A
D
A
F
Q
A
R
G
---
L
L
L
F
G
P
-
T
Q
-
K
A
A
M
I
E
G
S
K
-
A
F
A
K
G
L
M
E
RYG-------
I
P
----
T
A
R
-
Y
R
--
V
F
R
E
P
L
E
A
L
-
A
Y
L
E
E
V
G
V
P
--
V
V
V
K
D
S
G
L
-
A
A
G
K
G
V
T
V
A
-
F
-
D
L
H
Q
A
K
-
Q
A
V
A
N
I
L
---
N
R----
A
----------
E
G
G
E
V
V
V
E
E
Y
L
E
G
-
E
-
E
-
A
-
T
V
L
A
L
T
D
---
G
---
E
T
I
L
-
P
-
L
L-
P
-
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
--
T
G
G
M
G
A
--
V
--
A
P
Y
-----
P
-
M
--
D
----
E
-----
A
T
L
R
R
V
E
E
E
I
L
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
--
G
V
V
Y
A
G
L
M
L
----
T
REGP-
K
V
L
E
F
N
A
R
F
G
D
P
-
E
-
A
Q
---
A
L
L
P
L
L
E
N
D
L
V
E
L
A
L
R
V
A
E
G
R
L
A
G
T
R
L
S
W
K
E
14
HHSearch
45.37
13%
-71
- C3 -
1I7N
-
SYN2_RAT
A:
[131-420]
------------------------
F
R
G
K
K
I
L
G
D
Y
D
I
K
V
E
Q
A
E
F
S
E
L
-
N
-
L
-
V
-
A
H
A
D
G
T
Y
A
-
V
D
-
M
---
Q
------
V
----
L
--
R
N
G
T
-
K
-
V
V
R
S
F
R
P
D
F
V
L
I
R
Q
H
A
F
G
---
M
AEN
E
D
--
F
-
R
H
L
V
I
G
M
Q
Y
A
G
---
L
P
S
I
-
N
-
S
L
-
E
S
I
Y
N
F
C
D
K
-
P
W
V
F
A
Q
M
V
A
I
F
K
T
LGGEK
F
P
----
L
I
E
Q
T
Y
--
Y
P
N
H
R
-----
E
M
L
T
L
P
T
F
P
--
V
V
V
K
I
G
H
A
-
H
S
G
M
G
K
V
K
V
-
E
-
N
H
Y
D
F
Q
-
D
I
A
S
V
V
A
---
L
----------------
T
Q
T
Y
A
T
A
E
P
F
I
D
A
---
K
-
Y
-
D
I
R
V
Q
K
I
---
G
---
N
N
Y
K
-
A
-
Y
--
M
-
R
T
S
-
I
---
S
G
N
W
K
T
N
--
T
G
S
-
A
M
--
L
--
E
Q
I
-----
A
-
M
--
S
----
D
-----
R
Y
-----
K
L
W
V
D
A
C
S
E
M
F
---
G
G--
L
--
D
I
C
A
V
K
A
V
H
----
G
KDG
K
D
Y
I
F
E
V
M
D
C
-
S
M
P
L
I
-
G
----
E
H
Q
V
E
D
R
Q
L
I
T
D
L
V
I
S
K
M
N
Q
L
L
S
--------