@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0332: (2016-03-14 )
MWSFKSMFNTPEDPEKDAYEFYGKVQPGITTPTQKTCNFVALDLKSKDRDAIKAMFKKWTVMADRMMDGDTVGKTSNNPLMPPVDTGESIGLGASKLTITFGISKSLMKKIGLSSKIPDAFKDLPHFPNDQLIDDYSDGDIMIQACSNDSQVSFHAVHNLVRPFRDIVKVRWAQSGFISAKGKETPRNLMAFKDGTINPRKSNQLKDYVFIDDGWAKHGTYCVVRRIQIHIETWDRTALEEQEATFGRKRHSGAPLTGGKEFDEIDLKAKDSHGEYIIDKDAHTRLAKEANTSILRRAFNYVDGTDDRTGNFETGLLFIAFQKATKQFIDIQNNLGSNDKLNEYITHRGSASFLVLPGVSKGGYLGETLFD
Atome Classification :
(20 SA)
.........10........20........30-........40....--.-.--..50........60.........70.......--.80........90.-........100......-.110........120.....--------...--130...--....140.......150.......160.......170.....----..-----180.-----.----.....190....--...200--..-----------...-..210----.--------.---.--.....220.......230.....------------..240.-------......250.......260-........------------.270.......280.....---.----.290------.---...-.....300.......-----310.......320-.-..-..-..330...------.-------------.------.-----------------------.340.......350.......360.-.-......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MW
S
F
K
S
MFNTPEDPEK
D
A
Y
E
F
YGKVQPGITT-PTQKT
C
N
F
V
A
L
DLK--S-K--
D
R
D
A
I
K
A
M
F
K
K
W
T
-
V
M
A
D
RMMDGDTVGKTSNN--PLMPPVDTGESI-G-LGA
S
K
L
T
I
T
FGI
S
K
S
L
M
-
K
K-IGLSSKI
P
D
A
F
-
K
DLPH--------FPN--DQLIDD--YSDG
D
I
M
I
Q
ACSNDS
Q
V
S
F
H
A
V
H
N
L
V
R
P
F
R
D
I
V
K
V
R
WAQSG
F
----
I
S-----AKGK-----E----TPRN
L
M
AFKDGT--INPRKS--NQ-----------LK
D
-
Y
V
F
I-----D--------D---G--WAKHG
T
Y
C
V
V
R
R
I
Q
I
H
I
ETWDRT------------
A
L
E
E
Q
E
-------
A
T
FGRKRHSGAPLTGGK---EF
D
E
I
D
L
K
------------AKDSHG
E
Y
I
IDKDA
H
T
R
L
A
---
K
----EA--------
N
---
T
S
I
-
L
R
R
A
F
NYVDGTDDRT-----GNFET
G
L
L
F
I
A
F
Q
-
K
-
A
T
-
K
Q
-
F
I
D
I
Q
NNL------G-------------S------
N
-----------------------
D
K
L
N
E
Y
I
THRGS
A
S
F
L
V
LPGVS-KG-G-YLGETLFD
1
PsiBlast_PDB
93.73
43%
-77
- C6 -
4GRC
2
?
A:
[77-436]
-----------------
A
V
P
F
H
G
A
H
Q
A
G
I
A
T
-
P
V
Q
D
R
L
H
F
A
A
F
D
V
T
--
T
-
E
--
D
R
A
A
F
V
A
L
L
K
E
W
T
-
A
A
A
R
R
L
T
A
G
H
A
V
G
E
G
A
Y
G
GL
P
E
A
P
P
D
D
T
G
E
A
L
-
G
-
L
K
P
S
R
L
T
L
T
I
G
F
G
P
S
L
F
-
T
R
-
F
G
L
A
D
L
R
P
E
A
L
-
A
D
L
P
K
--------
F
P
G
--
D
N
L
D
R
A
--
R
S
G
G
D
L
C
V
Q
A
C
A
D
D
P
Q
V
A
V
H
A
I
R
N
L
A
R
I
G
F
G
K
V
V
V
R
W
S
Q
L
G
F
GKTS
S
T
-----
T
P
D
E
-----
Q
----
T
P
R
N
L
L
G
F
K
D
G
T
R
N
I
A
G
T
E
K
--
D
R
-----------
L
D
R
-
F
V
W
A
AE---
K
--------
D
---
G
TP
W
M
T
G
G
S
Y
L
V
A
R
R
I
R
M
H
I
E
T
W
D
R
A
------------
S
L
Q
E
Q
E
-------
D
V
F
G
R
D
K
G
E
G
A
P
V
G
K
A
K
---
E
R
D
E
P
F
L
K
------------
A
--------
M
K
P
D
A
H
V
R
L
A
HPD
S
----
N
G
--------
G
---
A
T
L
-
L
R
R
G
Y
S
F
T
D
G
T
D
-----------
D
A
G
L
F
F
L
A
Y
Q
-
R
-
D
I
-
R
T
G
F
V
P
V
Q
R
N
L
--------------------
A
------
T
-----------------------
D
A
L
N
E
Y
I
Q
H
V
G
S
A
V
F
A
V
P
P
G
V
R
-
D
A
D
D
-
W
W
G
S
T
L
F
-
3
PsiBlast_PDB
91.35
35%
-69
- C6 -
2Y4D
14
EFEB_ECOLI
A:
[28-401]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
D
H
A
A
R
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
K
L
---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
P----
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
24
PsiBlast_CBE
90.97
34%
-66
- C6 -
4GT2
5
?
G:
[102-464]
--------------------
F
H
G
K
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
--
A
G
A
--
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
-----------
D
T
D
V
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
-
G
R
-
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
----
N
R
-----
S
P
G
A
-----
T
AHPM
T
A
R
N
L
M
G
Q
V
D
G
T
--
R
N
P
K
P
G
--
E
A
-----------
D
F
D
R
R
I
F
V
-----
P
--------
E
P--
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
GAT
E
S
T
E
M
D
L
E
------------
K
T
D
G
S
G
E
L
V
V
P
I
N
A
H
A
R
I
T
---
R
PDQ-
N
G
--------
G
---
A
A
M
-
V
R
R
P
F
S
Y
H
D
G
F
D
A
-
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
-
A
D
P
L
-
R
G
-
F
V
P
V
Q
R
K
L
------
D
-------------
R
------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
L
F
A
V
P
G
G
A
A
-
E
G
-
E
-
Y
V
G
Q
R
L
L
E
6
PsiBlast_PDB
90.87
36%
-72
- C6 -
3O72
2
EFEB_ECO57
A:
[21-386]
--------------------
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
D
H
A
A
R
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
K
L
---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
G
I
A
-
L
D
S
H
I
R
L
A
---
N
PRTA
E
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
L
G
S
A
L
L
-
23
PsiBlast_CBE
90.59
35%
-69
- C6 -
2Y4D
13
EFEB_ECOLI
B:
[28-401]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
DHAAR
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
KL---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
P----
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
26
PsiBlast_CBE
90.49
34%
-67
- C6 -
4GT2
5
?
A:
[102-464]
--------------------
F
H
G
K
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
--
A
G
A
--
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
-----------
D
T
D
V
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
-
G
R
-
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
----
N
R
-----
S
P
G
A
-----
T
A
H
P
M
T
A
R
N
L
M
G
Q
V
D
G
T
--
R
N
P
K
P
G
--
E
A
-----------
D
F
D
R
R
I
F
V
-----
P
--------
E
EGP
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
GAT
E
S
T
E
M
D
L
E
------------
K
T
D
G
S
G
E
L
V
V
P
I
N
A
H
A
R
I
T
---
R
PDQ-
N
G
--------
G
---
A
A
M
-
V
R
R
P
F
S
Y
H
D
G
F
D
A
-
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
-
A
D
P
L
-
R
G
-
F
V
P
V
Q
R
K
L
------
D
-------------
R
------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
L
F
A
V
P
G
G
A
A
-
E
G
-
E
-
Y
V
G
Q
R
L
L
E
2
PsiBlast_PDB
90.44
35%
-70
- C6 -
2Y4F
10
EFEB_ECOLI
A:
[17-390]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
D
H
A
A
R
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
K
L
---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
PRT
A
E
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
21
PsiBlast_CBE
90.10
35%
-68
- C6 -
2Y4F
6
EFEB_ECOLI
B:
[17-390]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
DHAAR
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
KL---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
PRTA
E
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
22
PsiBlast_CBE
89.84
35%
-70
- C6 -
2Y4E
3
EFEB_ECOLI
B:
[28-401]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
DHAAR
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
KL---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
PRTA
E
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
5
PsiBlast_PDB
89.81
34%
-65
- C6 -
4GT2
6
?
B:
[102-464]
--------------------
F
H
G
K
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
--
A
G
A
--
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
-----------
D
T
D
V
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
-
G
R
-
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
----
N
R
-----
S
P
G
A
-----
T
A
H
P
M
T
A
R
N
L
M
G
Q
V
D
G
T
--
R
N
P
K
P
G
--
E
A
-----------
D
F
D
R
R
I
F
V
-----
P
--------
E
P--
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
GAT
E
S
T
E
M
D
L
E
------------
K
T
D
G
S
G
E
L
V
V
P
I
N
A
H
A
R
I
T
---
R
PDQ-
N
G
--------
G
---
A
A
M
-
V
R
R
P
F
S
Y
H
D
G
F
D
A
-
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
-
A
D
P
L
-
R
G
-
F
V
P
V
Q
R
K
L
------
D
-------------
R
------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
L
F
A
V
P
G
G
A
A
-
E
G
-
E
-
Y
V
G
Q
R
L
L
E
4
PsiBlast_PDB
88.93
35%
-66
- C6 -
2Y4E
5
EFEB_ECOLI
A:
[28-401]
------------
D
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
---
P
R
L
P
P
L
D
S
G
I
L
G
-
G
Y
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
R
-
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
D
H
A
A
R
S
K
G
K
-----
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
--
N
D
K
L
---------
M
Q
K
-
V
V
W
V
TADQQ
E
--------
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
-------------
A
S
D
P
E
G
K
-
V
I
A
L
D
S
H
I
R
L
A
---
N
PRTA
E
S
--------
E
---
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
-
S
-----
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
D
L
E
-
K
G
-
F
L
T
V
Q
K
R
L
--------------------
N
------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
-
D
A
-
N
D
Y
F
G
S
A
L
L
-
25
PsiBlast_CBE
88.87
34%
-65
- C6 -
4GT2
5
?
E:
[102-464]
--------------------
F
H
G
K
H
Q
P
G
I
T
T
-
P
M
Q
A
R
G
H
L
V
A
F
D
L
A
--
A
G
A
--
G
R
K
E
A
A
A
L
L
R
R
W
S
-
D
T
A
R
R
L
M
A
G
E
P
A
G
S
R
-----------
D
T
D
V
A
R
-
D
-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
-
G
R
-
T
G
L
E
E
Q
R
P
V
A
L
-
D
P
L
P
D
--------
F
S
S
--
D
H
L
D
K
N
--
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
----
N
R
-----
S
P
G
A
-----
T
AHPM
T
A
R
N
L
M
G
Q
V
D
G
T
--
R
N
P
K
P
G
--
E
A
-----------
D
F
D
R
R
I
F
V
-----
P
--------
E
EP-
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
------------
S
L
K
A
Q
E
-------
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
GAT
E
S
T
E
M
D
L
E
------------
K
T
D
G
S
G
E
L
V
V
P
I
N
A
H
A
R
I
T
---
R
PDQ-
N
G
--------
G
---
A
A
M
-
V
R
R
P
F
S
Y
H
D
G
F
D
A
-
D
-----
G
V
P
D
A
G
L
L
F
V
C
W
Q
-
A
D
P
L
-
R
G
-
F
V
P
V
Q
R
K
L
------
D
-------------
R
------
G
-----------------------
D
A
L
S
Q
F
I
R
H
E
A
S
G
L
F
A
V
P
G
G
A
A
-
E
G
-
E
-
Y
V
G
Q
R
L
L
E
28
HHSearch
88.19
35%
-65
- C6 -
3O72
2
EFEB_ECO57
A:
[13-387]
------------
V
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
-
P
Q
Q
A
A
M
M
L
V
A
F
D
V
L
--
A
-
S
--
D
K
A
D
L
E
R
L
F
R
L
L
T
-
Q
R
F
A
F
L
T
Q
G
G
A
A
P
E
T
P
N
P
---
R
L
P
P
L
D
S
G
I
L
G
G
Y
-
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
-
D
E
R
F
G
L
A
P
Q
M
P
K
K
L
-
Q
K
M
T
R
--------
F
P
N
--
D
S
L
D
A
A
--
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
----
I
S
-----
D
H
A
A
R
S
K
GK
E
----
T
P
I
N
L
L
G
F
K
D
G
T
--
A
N
P
D
S
Q
N
D
K
L
-----------
M
Q
K
-
V
V
W
V
-----
T
ADQQE---
P
---
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
------------
P
L
K
E
Q
Q
-------
T
I
F
G
R
D
K
Q
T
G
A
P
L
G
M
Q
H
---
E
H
D
V
P
D
Y
A
------------
S
-
D
P
E
G
K
-
G
I
A
L
D
S
H
I
R
L
A
---
N
----
P
R
TAESE---
S
---
S
L
M
-
L
R
R
G
Y
S
Y
S
L
G
V
T
N
S
------
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
-
H
-
D
L
E
K
G
-
F
L
T
V
Q
K
R
L
------
N
--------------------
G
-----------------------
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
A
N
-
D
-
Y
L
G
S
A
L
L
R
27
PsiBlast_CBE
73.38
37%
-61
- C6 -
4GS1
4
?
B:
[97-394]
-------------------------------------------------------------------------------------------------
S
A
-
G
-
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
-
E
A
-
M
D
A
A
D
R
R
P
D
A
L
-
A
D
L
P
E
--------
F
A
T
--
D
D
L
R
P
R
--
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
RR--
T
A
-----
A
A
A
Q
-----
D
PDA-
T
P
R
N
L
M
G
Q
I
D
G
T
--
A
N
P
A
Q
D
--
H
P
-----------
L
F
T
-
R
T
V
T
APPA-
D
--------
D
PAH
A
--
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
------------
D
V
P
D
R
E
-------
R
V
I
G
R
H
L
D
T
G
A
P
L
G
G
E
K
---
E
T
D
P
V
V
L
T
------------
A
R
D
A
D
G
R
L
V
I
P
E
D
A
H
V
R
L
A
---
N
----
P
E
--------
N
NLG
A
R
M
-
V
R
R
G
Y
N
Y
D
E
G
W
R
D
-
D
-----
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
-
P
A
-
T
G
-
F
V
P
V
Q
R
S
L
V-----
E
-------------
Q
------
G
-----------------------
D
A
L
N
R
Y
T
R
H
E
G
S
A
L
F
A
V
-
P
A
A
T
-
A
D
-
R
-
Y
P
G
Q
D
L
V
E
7
PsiBlast_PDB
72.95
37%
-59
- C6 -
4GS1
4
?
A:
[97-394]
-------------------------------------------------------------------------------------------------
S
A
-
G
-
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
-
E
A
-
M
D
A
A
D
R
R
P
D
A
L
-
A
D
L
P
E
--------
F
A
T
--
D
D
L
R
P
R
--
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
R
R--
T
A
-----
A
A
A
Q
-----
D
PD
A
-
T
P
R
N
L
M
G
Q
I
D
G
T
--
A
N
P
A
Q
D
--
H
P
-----------
L
F
T
-
R
T
V
T
APPA-
D
--------
D
PAH
A
--
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
------------
D
V
P
D
R
E
-------
R
V
I
G
R
H
L
D
T
G
A
P
L
G
G
E
K
---
E
T
D
P
V
V
L
T
------------
A
R
D
A
D
G
R
L
V
I
P
E
D
A
H
V
R
L
A
---
N
----
P
E
--------
N
NLG
A
R
M
-
V
R
R
G
Y
N
Y
D
E
G
W
R
D
-
D
-----
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
-
P
A
-
T
G
-
F
V
P
V
Q
R
S
L
V
-----
E
-------------
Q
------
G
-----------------------
D
A
L
N
R
Y
T
R
H
E
G
S
A
L
F
A
V
-
P
A
A
T
-
A
D
-
R
-
Y
P
G
Q
D
L
V
E
30
HHSearch
64.49
19%
-63
* C6 *
3QNS
8
?
A:
[10-316]
---------------------
R
L
A
P
Q
A
V
-
L
T
-
P
P
S
A
A
S
L
F
L
V
L
V
A
G
--
D
-
S
D
D
D
R
A
T
V
C
D
V
I
S
G
I
D
-
G
P
L
K
A
V
G
F
R
E
L
--------------------------
A
G
S
L
S
C
V
V
G
V
G
A
Q
F
W
-
D
R
-
V
S
-
A
S
S
K
P
A
H
L
-
H
P
F
V
P
--------
L
S
G
--
P
V
H
S
A
P
--
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
----
R
Y
-----
F
D
-------------
S
R
D
L
L
G
F
V
D
G
T
--
E
N
P
T
D
D
--
D
------------
A
A
D
-
S
A
L
I
-----
G
DE------
D
---
P
--
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
------------
S
T
E
E
Q
E
-------
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
--------------------------
D
------
A
Q
P
S
N
S
H
V
T
L
N
---
T
----
I
V
D
DDG
V
---
E
---
H
D
I
-
L
R
D
N
M
A
F
G
S
L
G
E
----------
A
E
Y
G
T
Y
F
I
G
Y
A
-
K
-
D
P
-
A
V
-
T
E
L
M
L
R
R
M
------
F
-------------
L
GEPPGN
Y
-----------------------
D
R
V
L
D
F
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
V
-
L
E
-
S
-
L
-------
29
HHSearch
63.69
17%
-65
- C6 -
2IIZ
5
?
A:
[8-308]
----------------------
P
R
E
Q
L
G
V
C
A
-
E
G
N
L
H
S
V
Y
L
M
F
N
A
N
--
D
-
N
--
V
E
S
Q
L
R
P
C
I
A
N
V
A
-
Q
Y
I
Y
E
L
T
D
Q
Y
S
--------------------------
D
S
A
F
N
G
F
V
A
I
G
A
N
Y
W
-
D
S
-
L
-
Y
P
E
S
R
P
E
M
L
-
K
P
F
P
A
--------
M
Q
E
--
G
N
R
E
A
P
--
A
I
E
Y
D
L
F
V
H
L
R
C
D
R
Y
D
I
L
H
L
V
A
N
E
I
S
Q
M
F
E
D
L
V
E
L
V
E
E
E
R
G
F
----
R
F
-----
M
D
-------------
S
R
D
L
T
G
F
V
D
G
T
--
E
N
P
K
G
R
--
H
------------
R
Q
E
-
V
A
L
V
-----
G
SE------
D
---
P
--
E
F
K
G
G
S
Y
I
H
V
Q
K
Y
A
H
N
L
S
K
W
H
R
L
------------
P
L
K
K
Q
E
-------
D
I
I
G
R
T
K
Q
D
N
I
E
Y
E
S
--------------------------
E
------
D
K
P
L
T
S
H
I
K
R
V
---
N
----
L
K
DENG
K
---
S
---
I
E
I
-
L
R
Q
S
M
P
Y
G
S
L
K
------------
E
Q
G
L
M
F
I
S
T
C
-
R
-
T
P
-
D
H
-
F
E
K
M
L
H
S
M
------
V
-------------
F
GDGAGN
H
-----------------------
D
H
L
M
H
F
T
S
A
L
T
G
S
S
F
F
A
P
S
L
D
F
-
L
M
-----------
31
HHSearch
63.45
17%
-63
- C6 -
2GVK
12
?
A:
[13-313]
-----------------------
I
P
Q
D
V
-
A
G
-
K
Q
G
E
N
V
I
F
I
V
Y
N
L
T
--
D
-
S
PD
T
V
D
K
V
K
D
V
C
A
N
F
S
-
A
M
I
R
S
M
R
N
R
F
P
--------------------------
D
M
Q
F
S
C
T
M
G
F
G
A
D
A
W
-
T
R
-
L
F
P
D
K
G
K
P
K
E
L
-
S
T
F
S
E
--------
I
K
G
--
E
K
Y
T
A
V
--
S
T
P
G
D
L
L
F
H
I
R
A
K
Q
M
G
L
C
F
E
F
A
S
I
L
D
E
K
L
K
G
A
V
V
S
V
D
E
T
H
G
F
----
R
Y
-----
M
D
-------------
G
K
A
I
I
G
F
V
D
G
T
--
E
N
P
A
V
D
--
E
N
-----------
P
Y
H
-
F
A
V
I
-----
G
EE------
D
---
A
--
D
F
A
G
G
S
Y
V
F
V
Q
K
Y
I
H
D
M
V
A
W
N
A
L
------------
P
V
E
Q
Q
E
-------
K
V
I
G
R
H
K
F
N
D
V
E
L
S
D
E
--------------------------------
E
K
P
G
N
A
H
N
A
V
T
---
N
----
I
G
D-------
D
---
L
K
I
-
V
R
A
N
M
P
F
A
N
T
S
K
----------
G
E
Y
G
T
Y
F
I
G
Y
A
-
S
-
T
F
-
S
T
-
T
R
R
M
L
E
N
M
------
F
-------------
I
GSPAGN
T
-----------------------
D
R
L
L
D
F
S
T
A
I
T
G
T
L
F
F
V
P
S
Y
D
L
-
L
G
-----------
42
Fugue
62.75
18%
-60
- C6 -
3QNS
8
?
A:
[8-318]
V
A
R
L
A
P
Q
--------------------
A
V
L
T
-
P
P
S
A
A
S
L
F
L
V
L
V
A
G
DS
D
-
D
--
D
R
A
T
V
C
D
V
I
S
G
I
D
-
G
P
L
K
A
V
G
F
R
E
L
A
G
S
--------------------------
L
S
C
V
V
G
V
G
A
Q
F
W
-
D
R
-
V
-
S
A
S
S
K
P
A
H
L
-
H
P
F
V
P
--------
L
S
G
--
P
V
H
S
A
P
--
S
T
P
G
D
L
L
F
H
I
K
A
A
R
K
D
L
C
F
E
L
G
R
Q
I
V
S
A
L
G
S
A
A
T
V
V
D
E
V
H
G
F
----
R
Y
-----
F
D
S
-------------
R
D
L
L
G
F
V
D
G
T
--
E
N
P
T
D
D
--
D
A
-----------
A
D
S
A
L
I
G
D
-----
E
--------
D
---
P
--
D
F
R
G
G
S
Y
V
I
V
Q
K
Y
L
H
D
M
S
A
W
N
T
L
------------
S
T
E
E
Q
E
-------
R
V
I
G
R
T
K
L
E
N
V
E
L
D
D
D
A
----------
Q
------------
P
S
N
S
H
V
T
L
N
T
I
V
D
D
D
G
V
--------------------
E
---
H
D
I
-
L
R
D
N
M
A
F
-----
G
S
L
-----
G
E
A
E
Y
G
T
Y
F
I
G
Y
A
-
K
-
D
P
-
A
V
-
T
E
L
M
L
R
R
M
F
LGEPP
G
-------------
N
------
Y
-----------------------
D
R
V
L
D
F
-
S
T
A
A
T
G
T
L
F
F
V
P
S
R
D
-
V
L
-
E
-
S
L
G
D
----
32
HHSearch
57.55
17%
-47
- C6 -
3VXJ
5
?
A:
[5-439]
------------------
I
L
P
L
N
N
I
Q
G
D
I
L
V
G
M
K
K
Q
K
E
R
F
V
F
F
Q
V
N
--
D
-
A
----
T
S
F
K
T
A
L
K
T
Y
V
P
E
R
I
T
S
A
A
I
L
I
S
--------------------
D
-
P
-
S
Q
Q
P
L
A
F
V
N
L
G
F
S
N
T
G
L
-
Q
A
-
L
G
I
---
T
D
D
L
G
D
A
Q
F
P
D
GQFADAAN
L
G
D
DL
S
Q
W
V
A
P
FT
G
T
T
I
H
G
V
F
L
I
G
S
D
Q
D
D
F
L
D
Q
F
T
D
D
I
S
S
T
F
G
S
S
I
T
Q
V
Q
A
L
S
G
S
----
A
R
-----
P
G
D
------
Q
----
A
G
H
E
H
F
G
F
L
D
G
I
--
S
Q
P
S
V
T
--
G
W
E
T
T
V
F
PG
Q
A
V
V
P
P
G
-
I
I
L
T
-----
G
RDGDTGTR
P
---
S
--
W
A
L
D
G
S
F
M
A
F
R
H
F
Q
Q
K
V
P
E
F
N
A
Y
T
L
A
N
AIPANSAG
N
L
T
Q
Q
E
G
A
E
F
L
G
A
R
M
F
G
R
W
K
-
S
G
A
P
I
D
L
A
P
---
T
A
D
D
P
A
L
G
A
DPQRNNNFDYS
D
T
L
T
D
E
T
-
R
C
P
F
G
A
H
V
R
K
T
---
N
----
P
R
QDLGGPVD
T
---
F
H
A
-
M
R
S
S
I
P
Y
G
P
E
T
S
D
A
E
L
A
S
GV
T
A
Q
D
R
G
L
L
F
V
E
Y
Q
-
S
-
I
I
G
N
G
-
F
R
F
Q
Q
I
N
W
------
A
NNANFPFSKPITP
G
------
I
EPIIGQTTPRTVGGLDPLNQNET
F
T
V
P
L
F
V
I
P
K
G
G
E
Y
F
F
L
P
S
I
S
A
-
L
T
-
A
-
T
-------