@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1788: (2015-12-10 )
MKEILVLGAGYAGLKAVRNLQKQSGDFHITLVDMNDYHYEATELHEVAAGSQPKEKITFPIKDVINTNKVNFMQDEVLKVDAENKTVTVKNNGELHYDYVVVALGFVSETFGIKGAMENALQMTNISQAENIHNHIVNTMKLYRETKDENLLKLLVCGAGFTGIELAGAMVDERPKYAALAGVKPEQIEIICVEAATRILPMFDDELAQYGVNLIKDLGINLMLGSMIKEIKPGEVVYGTSKEDEELKSITAGTIIWTTGVSGSPVMGESGFDQRRGRVMVNSDLRDPKYDNVYVIGDVSAFMDTESGRPFPTTAQIATRMGAHVAKNLLHQIKGEATEDFSYSPQGTVASVGNTHGLGVVGKTKIKKYPASVMKKIIMNKSLVDMGGLKELLAKGRFDLYH
Atome Classification :
(20 SA)
----------.........10........20..--..-....30.-.......40-.--....-...50.------.-------.--.-....60--------......--...--70-.-...-....80........90-------------------.--------------------.--.......100.......110.-.-....-.--.120--.........130....-...140..-----.....150.......160-------------------------.......170.-----......180.......190.......200.-.-......210.......220.......230...-----------------------.----...240..--...--..250.......260-.....-.-.------270--.-..-....280.......290.......300......-.-310........320.......330......-..340----------...--....--..350..-.....360.......370-.......380..---------.....390.......400---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------M
K
E
I
L
V
LGA
G
Y
A
G
L
K
A
V
R
N
L
Q
KQ--SG-
D
F
H
I
T
L
V
-DMNDYHY
E
A
-
T
--
E
L
H
E
-
V
AAGSQ------P-------K--
E
-
K
I
T
F
P
---------
I
K
D
VIN--TNK--VN-F-MQD-
E
V
L
K
VDAEN
K
T
V
T
VK--------------------N--------------------N--
G
E
L
H
Y
D
Y
V
V
V
A
L
G
F
V
S
E
T-FG-I-
K
G
A
M
-
E
--
N
A
----
L
Q
MTN
I
S
Q
A
E
N
I
H
N
H
I
-
V
N
T
M
K
L
Y
R
-----ETK
D
E
N
L
L
K
L
L
VCGAGF
T
-------------------------
G
I
E
L
A
G
A
M
VDE-----RPK
Y
A
ALAGVKP
E
Q
I
E
I
I
C
V
E
A
A
T
R
ILP-M-
F
-
D
D
E
L
A
Q
Y
G
V
N
L
I
K
D
LG
I
N
L
M
L
G
S
M
I
K
EIKPG
E
-----------------------
V
----
V
YGTSK
E
D
--
E
E
L
--
K
SITA
G
T
I
I
W
TTGVS-GSPVM-G-E------SGF--D-QR-R
G
R
V
M
VNSDLRDPKYD
N
V
Y
V
I
G
D
V
S
A
F
MDTESG-R-PF-
P
T
T
A
Q
I
A
T
R
M
G
A
H
V
A
K
N
L
L
-
H
Q
IKGEA-TED------------FSY--SPQG--
T
V
A
SVGN-THGLGVV
G
K
T
K
I
K
KY
P
A
S
-
V
M
K
K
I
IMNKSLV---------
D
M
G
G
L
K
E
L
L
AKGRFDLYH---------------
22
PsiBlast_CBE
90.47
41%
-108
- C1 -
4NWZ
1
?
B:
[6-397]
-------------
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
-
E
A
D
I
T
L
V
-
N
K
N
D
Y
H
Y
I
T
-
T
--
E
L
H
Q
-
P
A
A
G
T
M
------
H
-------
H
--
D
-
Q
A
R
V
G
---------
I
K
E
L
I
D
--
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
--------------------
N
-----------------------
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
-
I
-
E
G
L
R
-
E
--
H
A
----
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
-----
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
-----
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
----
V
I
E
V
D
G
E
E
--
E
E
I
--
K
---
A
A
T
V
V
W
T
G
G
V
R
-
G
N
S
I
V
-
E
-
K
------
S
G
F
--
E
-
T
M
-
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
Y
-
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
-
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
--
H
I
R
G
--
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
-
W
L
K
K
L
I
D
M
R
Y
L
Y
---------
L
I
G
G
L
S
L
V
L
K
K
G
---------------------
1
PsiBlast_PDB
89.99
41%
-109
- C1 -
4NWZ
1
?
A:
[6-397]
-------------
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
N
-
E
A
D
I
T
L
V
-
N
K
N
D
Y
H
Y
I
T
-
T
--
E
L
H
Q
-
P
A
A
G
T
M
------
H
-------
H
--
D
-
Q
A
R
V
G
---------
I
K
E
L
I
D
--
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
--------------------
N
-----------------------
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
-
I
-
E
G
L
R
-
E
--
H
A
----
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
-----
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
-----
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
----
V
I
E
V
D
G
E
E
--
E
E
I
--
K
---
A
A
T
V
V
W
T
G
G
V
R
-
G
N
S
I
V
-
E
-
K
------
S
G
F
--
E
-
T
M
-
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
Y
-
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
-
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
--
H
I
R
G
--
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
-
W
L
K
K
L
I
D
M
R
Y
L
Y
---------
L
I
G
G
L
S
L
V
L
K
K
G
---------------------
21
PsiBlast_CBE
89.27
41%
-108
- C1 -
4NWZ
1
?
C:
[6-396]
-------------
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
LN
Y
N
-
E
A
D
I
T
L
V
-
N
K
N
D
Y
H
Y
I
T
-
T
--
E
L
H
Q
-
P
A
A
G
T
M
------
H
-------
H
--
D
-
Q
A
R
V
G
---------
I
K
E
L
I
D
--
E
K
K
--
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
--------------------
N
-----------------------
G
E
L
H
Y
D
Y
L
V
V
G
L
G
S
E
P
E
T
-
F
G
-
I
-
E
G
L
R
-
E
--
H
A
----
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
-----
E
P
E
R
T
D
Y
L
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
-----
M
P
E
L
C
A
E
Y
D
V
D
P
K
L
V
R
I
I
N
V
E
A
A
P
T
V
L
P
-
G
-
F
-
D
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
G
-----------------------
V
----
V
I
E
V
D
G
E
E
--
E
E
I
--
K
---
A
A
T
V
V
W
T
G
G
V
R
-
G
N
S
I
V
-
E
-
K
------
S
G
F
--
E
-
T
M
-
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
L
I
I
N
E
E
N
N
-
R
-
P
Y
-
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
-
A
L
I
R
G
G
S
-
M
T
P
------------
F
K
P
--
H
I
R
G
--
T
V
A
S
L
G
R
-
N
D
A
I
G
I
V
G
G
R
K
V
Y
G
H
A
A
S
-
W
L
K
K
L
I
D
M
R
Y
L
Y
---------
L
I
G
G
L
S
L
V
L
K
K
----------------------
3
PsiBlast_PDB
72.69
24%
-121
- C1 -
4G6H
4
NDI1_YEAST
A:
[45-396]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
N
L
S
--
S
R
K
D
--
K
I
D
L
L
F
E
-
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
-
G
S
E
R
A
I
A
T
I
R
S
G
---------
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
---------------
4
PsiBlast_PDB
72.60
24%
-125
- C1 -
4G73
7
NDI1_YEAST
A:
[45-396]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
N
L
S
--
S
R
K
D
--
K
I
D
L
L
F
E
-
E
N
N
F
K
P
F
K
Y
N
D
L
G
A
L
A
Y
L
-
G
S
E
R
A
I
A
T
I
R
S
G
---------
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
---------------
5
PsiBlast_PDB
71.53
24%
-120
- C1 -
4G74
8
NDI1_YEAST
A:
[45-396]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
D
------------
K
I
D
--
L
L
F
E
--
E
N
N
F
K
P
F
-
K
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
-
T
I
R
S
G
K
R
T
F
Y
T
G
---------
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
---------------
8
PsiBlast_PDB
71.23
24%
-124
- C1 -
4GAV
2
NDI1_YEAST
A:
[14-365]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
I
D
L
--
L
F
E
E
--
N
N
F
K
P
F
K
-
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
-
I
R
S
G
K
R
T
F
Y
T
G
G
---------
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
---------------
2
PsiBlast_PDB
70.85
24%
-124
- C1 -
4G6G
6
NDI1_YEAST
A:
[45-396]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
LYQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
QDL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
I
D
L
--
L
F
E
E
--
N
N
F
K
P
F
K
-
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
-
I
R
S
G
K
R
T
F
Y
T
G
G
---------
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
---------------
6
PsiBlast_PDB
69.80
24%
-122
- C1 -
4G9K
1
NDI1_YEAST
A:
[14-365]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
I
D
L
--
L
F
E
E
--
N
N
F
K
P
F
K
-
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
-
I
R
S
G
K
R
T
F
Y
T
G
G
---------
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
---------------
7
PsiBlast_PDB
68.13
24%
-119
- C1 -
4GAP
2
NDI1_YEAST
A:
[14-365]
-------------
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
T
K
--
K
---
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
--
K
K
K
G
N
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
--------------------
S
LS
A
V
S
Q
L
YQPENHLGLHQA
E
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
DL
R
K
F
L
P
A
L
A
----
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
--
G
K
I
T
E
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
P
E
Q
N
--
S
-
S
K
-
R
G
-
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
-
N
A
F
A
G
--------
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
------------
I
D
L
--
L
F
E
E
--
N
N
F
K
P
F
K
-
Y
N
D
L
G
A
L
A
Y
L
G
S
E
R
A
I
A
T
-
I
R
S
G
K
R
T
F
Y
T
G
G
---------
G
L
M
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
---------------
49
Fugue
68.05
23%
-97
- C1 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
HSD
K
P
N
V
L
I
L
G
S
G
W
G
A
I
S
F
L
K
H
I
D
----
T
K
-
K
Y
N
V
S
I
I
-
S
P
R
S
Y
F
L
F
T
-
P
--
L
L
P
S
-
A
P
V
G
T
V
------
D
-------
E
--
K
-
S
I
I
E
P
---------
I
V
N
F
A
L
K
K
K
G
N
--
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
SLS
A
V
S
Q
L
YQPENHLGLHQA
E
--------------------
P
--
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
N
T
-
F
G
-
I
-
P
G
V
T
-
D
--
Y
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
LPKG
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
----
H
Q
D
L
R
K
F
L
P
A
L
A
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
L
N
-
M
-
F
-
E
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
Q
-----------------------
L
----
L
A
K
T
K
H
E
D
G
K
I
T
E
--
E
T
I
P
Y
G
T
L
I
W
A
T
G
N
K
-
A
R
P
V
I
-
T
-
D
L
F
K
K
I
-
P
E
Q
--
N
-
S
S
-
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
F
--------
A
-
G
L
-
P
P
T
A
Q
V
A
H
Q
E
A
E
Y
L
A
K
N
F
D
-
K
M
A
Q
I
P
N
-
F
Q
K
I
D
L
L
F
E
E
N
N
F
K
P
F
K
Y
--
N
D
L
G
--
A
L
A
Y
L
G
S
-
E
R
A
I
A
T
I
R
S
G
K
R
T
F
Y
T
G
G
G
L
M
T
F
Y
L
W
R
I
L
Y
L
---------
S
M
I
L
S
A
R
S
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL---
33
HHSearch
63.99
23%
-114
- C1 -
3NTD
2
?
A:
[1-338]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
--
S
E
-
T
A
E
I
I
M
F
-
E
R
G
E
Y
V
S
F
A
-
N
C-
G
L
P
Y
-
H
I
S
G
E
I
------
A
-------
Q
R
-
S
A
L
V
L
Q
T
---------
P
E
S
F
K
A
--
R
F
N
--
V
E
-
V
R
V
K
H
-
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
RLLDG---------------
S
--------------------
E
--
Y
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
-
P
P
-
I
-
P
G
V
D
-
N
P-
L
T
----
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
---------------
N
N
V
E
H
A
T
V
V
G
G
G
F
I
-------------------------
G
L
E
M
M
E
S
L
H
H
L
------------------
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
-
V
-
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
-
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
----
L
T
L
S
N
--
G
-------
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
-
P
E
T
Q
L
A
R
-
D
------
A
G
L
--
A
I
G
E
-
L
G
G
I
K
V
N
A
M
M
Q
T
-
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
-
Q
A
C
L
-
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
-
G
R
E
E
R
Y
Q
-
G
T
Q
------------
G
T
A
--
I
C
K
V
--
F
D
L
A
V
G
A
-
T
G
K
N
E
K
Q
L
K
Q
A
G
I
A
F
E
K
V
-
Y
V
H
T
A
S
H
A
S
Y
Y
P
---------
G
A
E
V
V
S
F
K
L
L
F
D
P
V
K
G
T
I
---------------
32
HHSearch
61.29
24%
-122
- C1 -
1XHC
1
?
A:
[9-297]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
------
T
Y
E
V
T
V
I
-
D
K
E
P
V
P
Y
Y
S
K
P
--
M
L
S
H
-
Y
I
A
G
F
I
------
P
-------
R
--
N
-
R
L
F
P
Y
---------
S
L
D
W
Y
R
--
K
R
G
--
I
E
-
I
-
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
-----------------------------------------
K
--
G
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
-
P
Q
-
I
-
K
G
K
--
E
--
Y
L
----
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
------------------
E
N
S
G
E
A
I
I
I
G
G
G
F
I
-------------------------
G
L
E
L
A
G
N
L
A
E
A
------------------
G
Y
H
V
K
L
I
H
R
G
A
M
F
L
--
G
-
L
-
D
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
-
E
E
-----------------------
G
----
V
L
T
-
N
--
S
-------
G
F
I
E
G
K
V
K
I
C
A
I
G
I
V
-
P
N
V
D
L
-
A
R
R
------
S
G
I
--
H
-
T
G
-
R
G
-
I
L
I
D
D
N
F
R
T
-
S
A
K
D
V
Y
A
I
G
D
C
A
E
Y
S
G
-------
I
I
-
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
-
G
E
P
R
R
Y
N
-
F
K
F
------------
R
S
T
--
V
F
K
F
--
G
K
L
Q
I
A
I
-
I
G
N
T
K
G
E
G
K
W
I
E
D
N
T
K
V
F
-
Y
I
G
A
V
V
F
N
D
I
R
K
---------
A
T
K
L
E
----------------------------
42
HHSearch
61.28
23%
-114
- C1 -
3IWA
1
?
A:
[4-329]
-----------
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
--
D
P
-
E
A
H
V
T
M
I
-
D
Q
A
-------------------------------------------------------------------
V
E
A
L
-
V
E
T
-
R
A
H
A
I
D
R
A
A
H
T
V
E
I
E
--------------------
N
LRTG
E
---------------
R
--
R
T
L
K
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
-
P
P
-
V
-
E
G
M
D
L
A
--
G
V
----
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
-
S
A
---------------
G
E
V
S
K
A
V
I
V
G
G
G
F
I
-------------------------
G
L
E
M
A
V
S
L
A
D
M
-----
W
------------
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
-
G
-
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
H
T
G
E
K
V
V
R
L
E
-
G
E
-----------------------
N
GKVA
R
V
I
T
D
--
K
-------
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
-
P
N
T
Q
L
-
A
R
D
------
A
G
L
--
E
L
D
P
-
R
G
A
I
I
V
D
T
R
M
R
T
-
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
T
G
K
P
-
G
F
-
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
-
D
G
D
A
T
F
P
-
G
A
V
------------
G
S
W
--
A
V
K
L
--
F
E
G
S
A
S
G
-
A
G
L
T
V
E
G
A
L
R
E
G
Y
D
A
V
N
V
-
H
V
E
Q
I
M
T
L
Q
L
V
V
---------
D
R
P
T
R
R
V
L
G
I
Q
G
F
S
T
L
G
D
---------------
37
HHSearch
61.13
23%
-118
- C1 -
3ICS
2
?
A:
[36-353]
----------
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
--
S
E
-
E
D
E
I
I
M
V
-
E
R
G
E
Y
I
S
F
A
-
N
C-
G
L
P
Y
-
Y
I
G
G
V
I
------
T
-------
E
RQ
K
-
L
L
V
Q
T
---------
V
E
R
M
S
K
--
R
F
N
--
L
D
-
I
R
V
L
S
-
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
--------------------
N
VTTN
E
---------------
T
--
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
-
P
S
-
I
-
P
G
I
E
-
E
AK
A
L
----
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
-
D
E
---------------
K
K
P
R
H
A
T
V
I
G
G
G
F
I
-------------------------
G
V
E
M
V
E
N
L
R
E
R
------------------
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
-
I
-
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
-
E
N
-----------------------
G
A
V
--
V
R
L
K
S
--
G
-------
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
-
P
E
S
S
L
-
A
K
G
------
A
G
L
--
A
L
G
V
-
R
G
T
I
K
V
N
E
K
F
Q
T
-
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
-
T
E
T
M
-
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
-
G
H
T
D
S
L
Y
-
K
G
T
------------
L
G
T
--
S
V
A
K
--
V
F
D
L
T
V
A
-
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
-
V
H
V
Q
A
N
S
H
A
G
Y
Y
---------
P
N
A
T
P
V
L
I
K
L
I
F
N
K
D
S
G
K
---------------
26
HHSearch
57.83
20%
-106
- C1 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
--
V
G
S
K
A
D
V
K
V
I
-
N
K
S
R
F
S
Y
F
R
-
P
--
A
L
P
H
-
V
A
I
G
V
R
------
D
-------
V
--
D
-
E
L
K
V
D
---------
L
S
E
A
L
P
--
E
K
G
--
I
Q
-
F
-
Q
E
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
T
K
P------------------
D
--------------------
G
S
M
A
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
-
E
L
-
V
-
K
G
W
D
-
K
--
Y
G
----
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
-
E
S
F
---------------
Q
G
G
N
I
A
I
-
G
S
G
P
F
YQGHNPKPKVPENF
V
P
N
A
DSACE
G
P
V
F
E
M
S
L
M
L
H
G
Y
-----
F
K
K
K
----
G
M
L
D
-
K
V
H
V
T
V
F
S
P
G
E
-
Y
L
S
-
D
-
L
-
S
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
K
E
I
R
-
E
H
-----------------------
E
----
I
V
D
E
K
--
G
-------
N
T
I
P
A
D
I
T
I
L
L
P
P
Y
T
-
G
N
P
A
L
-
K
-
N
------
S
T
P
DL
V
-
D
D
-
G
G
F
I
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
S
M
T
V
----------
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
-
N
R
L
G
V
P
T
K
V
D
K
------------
Y
Y
P
---
T
I
V
--
C
V
A
D
N
P
Y
E-------------------------------------------------------------------------
30
HHSearch
57.72
22%
-122
- C1 -
2GQW
5
?
A:
[7-308]
----------
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
--
G
Y
-
Q
G
L
I
T
V
V
-
G
D
E
A
E
R
P
Y
D
R
P
--
P
L
S
K
-
D
F
M
A
H
G
------
D
-------
A
--
E
-
K
I
R
L
D
------------
C
K
R
--
A
P
E
--
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
--------------------
D
--------------------
G
--
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
-
L
-
Q
G
A
T
-
M
--
P
V
----
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
------------------
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
A
R
T
A
------------------
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
-
R
A
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
-
D
G
-----------------------
V
----
V
L
L
D
D
--
G
-------
T
R
I
A
A
D
M
V
V
V
G
I
G
V
L
-
A
N
D
A
L
-
A
-
R
A
-----
A
G
L
--
A
--
C
-
D
D
G
I
F
V
D
A
Y
G
R
T
-
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
-
R
F
E
R
-
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
-
D
P
T
A
P
G
Y
-
A
E
L
------------
P
W
Y
--
W
S
D
Q
--
G
A
L
R
I
Q
V
-
A
G
L
A
S
G
D
E
E
I
V
R
G
E
V
S
L
D
-
A
P
K
F
T
L
I
E
L
Q
K
G
---------
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
P
L
R
---------------
51
Fugue
57.43
22%
-95
- C1 -
1D7Y
1
?
A:
[5-405]
--------AL
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
--
G
Y
-
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
-
P
--
P
L
S
K
-
D
F
M
A
H
G
------
D
-------
A
--
E
-
K
I
R
L
D
---------
C
K
R
A
P
E
--
V
E
W
--
L
L
----
G
V
-
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
--------------------
D
--------------------
G
--
R
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
-
L
P
-
T
L
Q
G
A
T
-
M
--
P
V
----
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
------------------
R
P
Q
S
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
A
R
T
A
-----
G
-------------
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
A
-
A
-
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
V
-----------------------
V
----
L
L
D
D
G
T
----------
R
I
A
A
D
M
V
V
V
G
I
G
V
L
A
N
D
A
L
A
-
R
-
A
------
A
G
L
--
A
-
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
-
T
T
C
P
D
V
Y
A
L
G
D
V
T
R
Q
R
N
P
L
S
G
-
R
-
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
A
P
G
Y
A
-
E
L
P
------------
W
Y
W
--
S
D
Q
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AL
R
I
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V
A
G
L
-
A
S
G
D
E
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R
G
E
V
S
L
D
A
P
K
-
F
T
L
I
E
L
Q
K
G
R
I
V
G
A
T
C
V
NN
A
R
D
F
A
P
L
R
R
L
L
A
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G
A
K
P
D
R
A
A
L
A
DPAT
D
L
R
K
L
A
A
A
36
HHSearch
56.17
19%
-108
* C1 *
3FG2
2
?
P:
[1-336]
----------
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
--
K
Y
-
P
G
R
I
A
L
I
-
N
D
E
K
H
L
P
Y
Q
-
R
PP
L
S
K
A
-
Y
L
K
S
G
G
------
D
-------
P
--
N
-
S
L
M
F
R
---------
P
E
K
F
F
Q
--
D
Q
A
--
I
E
-
L
-
I
S
D
-
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
--------------------
S
--------------------
G
--
T
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
-
L
D
-
V
-
P
N
A
S
L
P
--
D
V
----
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
------------------
P
D
K
K
H
V
V
V
I
G
A
G
F
I
-------------------------
G
L
E
F
A
A
T
A
R
A
K
------------------
G
L
E
V
D
V
V
E
L
A
P
R
V
M
A
-
R
V
V
-
T
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
R
A
T
E
I
A
-
A
E
GDRVT------------------
G
----
V
V
L
S
D
--
G
-------
N
T
L
P
C
D
L
V
V
V
G
V
G
V
I
-
P
N
V
E
I
A
A
-
A
------
A
G
L
--
P
-
T
--
A
A
G
I
I
V
D
Q
Q
L
L
T
-
S
D
P
H
I
S
A
I
G
D
C
A
L
F
E
S
V
R
F
G
-
E
T
M
R
-
V
E
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V
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A
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Q
A
R
C
V
A
A
R
L
T
-
G
D
A
K
P
Y
D
-
G
Y
P
------------
W
F
W
SD
Q
G
D
D
--
K
L
Q
I
V
G
L
-
T
A
G
F
D
Q
V
V
I
R
G
S
V
A
E
R
S
F
-
S
A
F
C
Y
K
A
G
K
L
I
G
---------
I
E
S
V
N
R
A
A
D
H
V
F
G
R
K
I
L
P
---------------
40
HHSearch
56.10
17%
-118
- C1 -
1M6I
1
AIFM1_HUMAN
A:
[11-352]
----------
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
--
D
P
-
G
A
R
V
L
I
V
-
S
E
D
P
E
L
P
Y
M
R
P
--
P
L
S
K
E
L
W
F
S
-
P
NVTKTL
R
FKQWNG
K
E
--
R
-
S
I
Y
F
Q
PPSFYVSAQ
D
L
P
H
I
E
--
N
G
G
--
V
A
-
V
-
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
--------------------
D
--------------------
G
--
S
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
-
L
S
A
I
-
D
R
A
G
-
A
--
E
V
K
S
R
T
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
------------------
R
E
V
K
S
I
T
I
I
G
G
G
F
L
-------------------------
G
S
E
L
A
C
A
L
G
R
K
-----
A
R
A
L
---------
G
T
E
V
I
Q
L
F
P
E
K
G
N
M
G
K
I
-
L
-
P
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
-
V
S
SG---------------------
K
L
L
--
I
K
L
K
D
--
G
-------
R
K
V
E
T
D
H
I
V
A
A
V
G
L
E
-
P
N
V
E
L
-
A
-
K
T-----
G
G
L
--
E
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
--
R
S
N
I
W
V
A
G
D
A
A
C
F
Y
D
I
K
L
G
-
R
-
R
R
-
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
-
G
A
A
K
P
Y
W
-
H
Q
S
------------
M
F
W
--
S
D
L
G
--
P
D
V
G
Y
E
A
-
I
G
L
V
D
S
S
L
P
T
V
G
V
F
A
K
A
T
-
A
Q
D
N
P
K
S
A
T
E
Q
S
---------
G
T
G
I
R
S
E
S
E
T
E
S
E
A
S
Y
G
K
---------------