@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0146: (2015-12-23 )
MKHRRTQSRMSVLRRLAAVLGLGACALAAEAAEPLKIGFVYVGPVGDHGWTYQHELGRRELVEHFGDKVKTSFVENVAEGADAERVIRNLAKDGYGLVFTTSFGYMNPTAKVARQFPKVTFEHATGYKRDRNLGTYLSRSYEGRYVGGFLAAKMTRSHKIGYIASFPIPEVIRDINAIQLALDKYDPQAELKVMWVSTWFDPGKEADAANALIDQGVDVVFQHTDSPAPIQAAERRGVYAVGYASDMQHFGPKTVLTSIVNDWGPHYIRSAQAVMDGTWKSEDFWGGLAESTVVLPLNQEVLPAPVREEAGRLIESIRSGAFHPFTGPIRDQSGKERFAAGVSATKADLASMNYYVEGIKADLPK
Atome Classification :
(20 SA)
------------------.........10........20........30........40-..--......50........60........70--......--..80.....--...90-........100....-.--..110.......120.....-..--130-........140.--------......---150..-.-----..---..160.....-.-.-170.......180.......190.---------......200.......210..-----.....220---.--.-....--.230....-----.-------..240........---250---.-----...-----.....260.......270.......-280.-.......290...-.-...--300.......310.......320.......330.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------MKH
R
R
T
Q
S
R
M
S
V
L
R
R
L
A
A
V
L
G
L
G
A
C
A
L
A
A
EAAE
P
L
K
I
G
F
V
Y
-VG--PVGDHGW
T
Y
Q
H
EL
G
R
R
E
L
V
E
H
F
G
D
K
V
K
T
--
S
F
V
E
N
V
--
A
EGA
D
A
E
R
V
--
I
R
N
L
A
-KDGY
G
L
V
F
T
TSFGYM-N--
P
T
A
K
V
A
R
QFP
K
V
T
F
EHATGY-KR--D-R-
N
L
G
T
Y
L
S
RSYEG--------R
Y
V
G
G
F
---
L
A
A
K
M
-T-----RS---HKI
G
Y
I
ASF
P
-
I
-
P
-
E
V
I
R
D
I
N
A
I
Q
L
A
L
DKYDPQA
E
L
K
V
---------
M
W
V
STWFDPGKEA
D
A
A
N
A
L
I
D-----QGV
D
V
V
F
Q---H--T-DSPA--
P
I
Q
A
A
ERR-----
G
-------
V
Y
A
V-GY
A
S
D
M
Q
H---F-----G-----
P
K
T
-----
V
L
T
S
I
V
N
DWG
P
H
Y
I
R
S
A
Q
A
V
MDGTW-KS-
E
-
D
FWGGLAE
S
T
V
V
L
-P-LNQ--EVLPA
P
V
R
E
E
A
G
R
L
I
E
S
I
RSGAFHPFTGPIRDQSG
K
E
R
F
A
AGVS
A
T
K
A
D
L
A
S
M
N
Y
Y
V
EGIKADLPK
1
PsiBlast_PDB
99.73
54%
-83
- C2 -
3S99
16
PBP_BRUA2
A:
[26-355]
---------------------------------------------------
K
L
K
V
G
F
I
Y
-
I
G
--
P
P
G
D
F
G
W
T
Y
Q
H
D
Q
A
R
K
E
L
V
E
A
L
G
D
K
V
E
T
--
T
F
L
E
N
V
--
A
E
G
A
D
A
E
R
S
--
I
K
R
I
A
-
R
A
G
N
K
L
I
F
T
T
S
F
G
Y
M
-
D
--
P
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
-
K
T
--
A
-
D
-
N
M
S
A
Y
N
A
R
F
Y
E
G
--------
R
Y
V
Q
G
V
---
I
A
A
K
M
-
S
-----
K
K
---
G
I
A
G
Y
I
G
S
V
P
-
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
R
V
K
V
---------
I
W
V
N
S
W
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
-----
Q
G
V
D
I
I
T
Q
---
H
--
T
-
D
S
T
A
--
A
I
Q
V
A
H
D
R
-----
G
-------
I
K
A
F
-
G
Q
A
S
D
M
I
K
---
F
-----
A
-----
P
D
T
-----
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
-
K
S
-
Q
-
N
I
W
W
G
M
K
E
G
L
V
K
M
A
P
-
F
T
N
----
M
P
D
D
V
K
K
L
A
E
E
T
E
A
R
I
K
S
G
E
L
N
P
F
T
G
P
I
K
K
Q
D
G
S
E
W
L
K
A
G
E
K
A
D
D
Q
T
L
L
G
M
N
F
Y
V
A
G
V
D
D
K
L
P
-
39
Fugue
98.93
54%
-79
- C2 -
3S99
16
PBP_BRUA2
A:
[26-355]
---------------------------------------------------
K
L
K
V
G
F
I
Y
-
I
G
--
P
P
G
D
F
G
W
T
Y
Q
H
D
Q
A
R
K
E
L
V
E
A
L
G
D
K
V
E
T
--
T
F
L
E
N
V
--
A
E
G
A
D
A
E
R
S
--
I
K
R
I
A
-
R
A
G
N
K
L
I
F
T
T
S
F
G
Y
M
-
D
--
P
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
-
K
T
--
A
-
D
-
N
M
S
A
Y
N
A
R
F
Y
E
G
--------
R
Y
V
Q
G
V
---
I
A
A
K
M
-
S
-----
K
K
---
G
I
A
G
Y
I
G
S
V
P
-
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
R
V
K
V
---------
I
W
V
N
S
W
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
-----
Q
G
V
D
I
I
T
Q
---
H
--
T
-
D
S
T
A
--
A
I
Q
V
A
H
D
R
-----
G
-------
I
K
A
F
-
G
Q
A
S
D
M
I
K
---
F
-----
A
-----
P
D
T
-----
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
-
K
S
-
Q
-
N
I
W
W
G
M
K
E
G
L
V
K
M
-
A
-
P
F
T
--
N
M
-
P
D
D
V
K
K
L
A
E
E
T
E
A
R
I
K
S
G
E
L
N
P
F
T
G
P
I
K
K
Q
D
G
S
E
W
L
K
A
G
E
K
A
D
D
Q
T
L
L
G
M
N
F
Y
V
A
G
V
D
D
K
L
P
-
17
HHSearch
98.31
53%
-80
- C2 -
3S99
16
PBP_BRUA2
A:
[26-355]
---------------------------------------------------
K
L
K
V
G
F
I
Y
-
I
G
--
P
P
G
D
F
G
W
T
Y
Q
H
D
Q
A
R
K
E
L
V
E
A
L
-
G
-
D
K
V
E
T
T
F
L
E
N
V
--
A
E
G
A
D
A
E
R
S
--
I
K
R
I
A
-
R
A
G
N
K
L
I
F
T
T
S
F
G
Y
M
-
D
--
P
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
-
K
T
--
A
-
D
-
N
M
S
A
Y
N
A
R
F
Y
E
G
--------
R
Y
V
Q
G
V
---
I
A
A
K
M
-
S
-----
K
K
---
G
I
A
G
Y
I
G
S
V
P
-
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
R
V
K
V
---------
I
W
V
N
S
W
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
-----
Q
G
V
D
I
I
T
Q
---
H
--
T
-
D
S
T
A
--
A
I
Q
V
A
H
D
R
-----
G
-------
I
K
A
F
-
G
Q
A
S
D
M
I
K
---
F
-----
A
-----
P
D
T
-----
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
-
K
S
-
Q
-
N
I
W
W
G
M
K
E
G
L
V
K
M
-
A
-
P
F
---
T
N
M
P
D
D
V
K
K
L
A
E
E
T
E
A
R
I
K
S
G
E
L
N
P
F
T
G
P
I
K
K
Q
D
G
S
E
W
L
K
A
G
E
K
A
D
D
Q
T
L
L
G
M
N
F
Y
V
A
G
V
D
D
K
L
P
-
40
Fugue
73.57
22%
-76
- C2 -
2FQX
1
TMPC_TREPA
A:
[3-318]
--------------------------------------------------
G
D
F
V
V
G
M
V
T
D
S
G
--
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
--
A
K
C
--
K
Y
V
T
A
---
S
T
D
A
E
Y
V
P
S
--
L
S
A
F
A
-
D
E
N
M
G
L
V
V
A
C
G
S
F
L
V
-
E
--
A
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
Q
D
--
R
-
D
-
N
V
V
S
A
V
F
G
Q
N
E
G
--------
S
F
L
V
G
V
---
A
A
A
L
K
-
A
-----
K
E
A
GK
S
A
V
G
F
I
V
G
M
E
-
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
Q
V
V
V
---------
E
V
A
N
T
F
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
-----
S
G
V
N
V
I
F
Q
---
V
A
G
G
-
T
G
N
G
--
V
I
K
E
A
R
D
R
-----
R
L
N
GQD--
V
W
V
I
-
G
V
D
R
D
Q
Y
M
---
D
-----
G
-----
V
Y
D
GSKSV
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
-
P
G
G
Q
-
S
I
M
F
G
L
E
D
K
A
V
G
I
-
P
-
E
E
N
--
P
N
L
S
S
A
V
M
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
--------------------------------
V
P
V
R
S
A
R
M
M
N
18
HHSearch
71.86
22%
-73
- C2 -
2FQX
1
TMPC_TREPA
A:
[3-314]
--------------------------------------------------
G
D
F
V
V
G
M
V
T
D
S
G
--
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
-
N
-
A
K
C
--
K
Y
V
T
A
S
--
T
D
-
A
E
Y
V
P
S
--
L
S
A
F
A
-
D
E
N
M
G
L
V
V
A
C
G
S
F
L
V
-
E
--
A
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
-
V
Q
D-
R
-
D
-
N
V
V
S
A
V
F
G
Q
N
E
G
--------
S
F
L
V
G
V
---
A
A
A
L
K
-
A
-----
K
E
A
GK
S
A
V
G
F
I
V
G
M
E
-
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
Q
V
V
V
---------
E
V
A
N
T
F
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
-----
S
G
V
N
V
I
F
Q
---
V
--
A
-
G
G
T
G
N
G
V
I
K
E
A
R
D
R
R
L
N
GQ
D
-------
V
W
V
I
-
G
V
D
R
D
Q
Y
M
---
D
GVYDG
S
-----
K
S
V
-----
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
-
P
G
-
G
Q
S
I
M
F
G
L
E
D
K
A
V
G
I
-
P
E
E
N
---
P
N
L
S
S
A
V
M
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
P
V
R
S
A
R
M
M
N
--------------------------------
2
PsiBlast_PDB
66.84
24%
-79
- C2 -
4P98
20
?
A:
[48-308]
---------------------------------------------------------------------------------------
D
G
A
D
V
--
Q
I
R
Q
G
L
--
A
D
P
T
Q
A
E
P
V
--
I
R
Q
F
A
-
A
R
G
F
D
L
V
V
G
H
G
I
D
V
S
-
E
--
P
I
L
R
V
A
T
E
F
P
D
V
H
F
-
S
A
S
G
------
D
-
A
-
T
L
A
E
R
L
P
P
N
V
D
G
W
T
Y
D
F
G
Q
L
G
Y
L
D
G
F
---
V
A
G
S
L
-
R
-----
G
V
---
E
K
V
G
A
V
G
G
P
Q
-
L
-
P
-
F
V
L
A
T
H
K
G
I
R
A
G
L
K
A
A
N
P
R
A
S
Y
E
E
---------
T
Y
T
G
R
F
Y
D
L
Q
K
E
Q
E
A
A
R
G
L
L
D
-----
K
G
A
Q
L
L
V
A
---
T
--
D
-
D
G
R
G
--
L
G
Q
A
A
V
A
G
-----
D
-------
V
P
T
I
-
G
V
S
A
A
A
G
A
---
D
-----
I
-----
K
A
V
-----
N
I
T
T
A
-
L
D
L
L
P
T
Y
Q
S
Y
L
E
Q
I
R
A
G
T
F
-
G
R
-
R
-
F
D
V
L
A
L
G
N
R
G
I
V
L
T
P
-
I
T
A
V
G
D
V
V
P
D
D
L
Q
A
R
V
D
A
L
S
E
R
L
A
S
G
E
L
R
L
P
N
F
F
E
------------------------------------
6
PsiBlast_PDB
65.07
24%
-69
- C2 -
2FQY
1
TMPC_TREPA
A:
[43-304]
---------------------------------------------------------------------------------------------------
V
--
T
A
S
T
D
A
E
Y
V
P
S
L
S
A
F
A
-
D
E
N
M
G
L
V
V
A
C
G
S
F
L
V
-
E
--
A
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
-
V
Q
--
D
-
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
--------
S
F
L
V
G
V
A
A
A
L
K
A
K
E
-
A
-----
G
K
---
S
A
V
G
F
I
V
G
M
E
-
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
Q
V
V
V
---------
E
V
A
N
T
F
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
-----
S
G
V
N
V
I
F
Q
VA
G
G
--
T
-
G
N
G
V
--
I
K
E
A
R
D
R
R
L
N
GQ-
D
-------
V
W
V
I
-
G
V
D
R
D
Q
Y
M
---
D
-----
G
VYDGS
K
S
V
-----
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
-
Q
-
S
I
M
F
G
L
E
D
K
A
V
G
I
-
P
-
E
E
N
--
P
N
L
S
S
A
V
M
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
P
V
R
S
A
R
M
M
N
--------------------------------
5
PsiBlast_PDB
64.83
24%
-64
- C2 -
2FQX
1
TMPC_TREPA
A:
[43-304]
---------------------------------------------------------------------------------------------------
V
--
T
A
S
T
D
A
E
Y
V
P
S
L
S
A
F
A
-
D
E
N
M
G
L
V
V
A
C
G
S
F
L
V
-
E
--
A
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
-
V
Q
--
D
-
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
--------
S
F
L
V
G
V
A
A
A
L
K
A
K
E
-
A
-----
G
K
---
S
A
V
G
F
I
V
G
M
E
-
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
Q
V
V
V
---------
E
V
A
N
T
F
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
-----
S
G
V
N
V
I
F
Q
VA
G
G
--
T
-
G
N
G
V
--
I
K
E
A
R
D
R
R
L
N
GQ-
D
-------
V
W
V
I
-
G
V
D
R
D
Q
Y
M
---
D
-----
G
VYDGS
K
S
V
-----
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
-
Q
-
S
I
M
F
G
L
E
D
K
A
V
G
I
-
P
-
E
E
N
--
P
N
L
S
S
A
V
M
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
P
V
R
S
A
R
M
M
N
--------------------------------
4
PsiBlast_PDB
64.66
24%
-65
- C2 -
2FQW
1
TMPC_TREPA
A:
[43-304]
---------------------------------------------------------------------------------------------------
V
--
T
A
S
T
D
A
E
Y
V
P
S
L
S
A
F
A
-
D
E
N
M
G
L
V
V
A
C
G
S
F
L
V
-
E
--
A
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
-
V
Q
--
D
-
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
--------
S
F
L
V
G
V
A
A
A
L
K
A
K
E
-
A
-----
G
K
---
S
A
V
G
F
I
V
G
M
E
-
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
Q
V
V
V
---------
E
V
A
N
T
F
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
-----
S
G
V
N
V
I
F
Q
VA
G
G
--
T
-
G
N
G
V
--
I
K
E
A
R
D
R
R
L
N
GQ-
D
-------
V
W
V
I
-
G
V
D
R
D
Q
Y
M
---
D
-----
G
VYDGS
K
S
V
-----
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
-
Q
-
S
I
M
F
G
L
E
D
K
A
V
G
I
-
P
-
E
E
N
--
P
N
L
S
S
A
V
M
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
P
V
R
S
A
R
M
M
N
--------------------------------
44
Fugue
57.85
20%
-60
- C2 -
4B46
1
CETZ1_HALVD
A:
[1-367]
MKLA
M
I
G
F
G
Q
A
G
G
K
V
V
D
K
F
V
E
Y
D
R
E
R
N
A
G
I
V
R
A
A
V
A
V
N
S
A
K
A
D
L
L
G
L
K
N
I
P
K
D
Q
R
V
L
I
G
-
Q
S
--
R
V
K
G
H
G
V
G
A
D
N
E
L
G
A
-
E
I
A
E
E
D
I
D
E
V
Q
G
--
A
I
D
S
I
P
--
V
H
E
V
D
----------------
A
F
L
V
V
S
G
L
G
---------------------
G
G
T
G
S
-
G
G
--
A
-
P
-
V
L
A
K
H
L
K
R
I
Y
T
E
--------
P
V
Y
G
L
G
---
I
L
P
G
S
-
D
-----
E
G
---
G
I
Y
T
L
N
A
A
R
S
-
F
-
Q
-
T
F
V
R
E
V
D
N
L
-
L
V
F
D
--------
N
D
---------
A
W
R
K
T
G
E
S
V
Q
G
G
Y
D
E
I
N
E
E
I
V
-----
N
R
F
G
V
L
F
G
---
S
--
V
V
D
S
S
E
--
I
I
N
T
L
A
G
G
-----
G
-------
V
S
T
V
-
G
Y
A
S
E
G
V
T
---
A
-----
H
-----
T
T
N
-----
R
I
T
S
L
V
R
K
A
A
L
G
R
L
---------
T
L
-
P
C
-
E
-
I
--
E
G
A
E
R
A
L
L
V
L
-
A
-
G
P
P
--
E
H
L
N
R
K
G
I
E
R
G
R
K
W
I
E
E
-
Q
T
G
S
M
-
E
V
R
G
G
D
Y
P
I
P
G
A
E
K
V
A
G
V
I
L
L
S
G
V
T
N
V
P
R
I
K
E
L
Q
Q
V
A
I
E
A
Q
D
34
HHSearch
54.66
12%
-65
* C2 *
3BRS
-
?
A:
[5-258]
---------------------------------------------------
Q
Y
Y
M
I
C
I
P
-
K
V
--
L
D
D
S
S
D
F
W
S
V
L
V
E
G
A
Q
M
A
A
K
E
Y
-
E
-
I
K
L
--
E
F
M
A
P
E
KE
E
D
Y
L
V
Q
N
E
L
--
I
E
E
A
I
-
K
R
K
P
D
V
I
L
L
A
A
A
D
Y
E
-
K
TY
D
A
A
K
E
I
K
D
-
A
G
I
K
L
I
V
I
D
S
G
-
M
K
Q-
D
-
I
-
A
D
I
T
V
A
T
D
N
I
Q
A
--------
G
I
R
I
G
A
---
V
T
K
N
L
-
V
R
----
K
S
---
G
K
I
G
V
I
S
F
V
K
-
N
S
K
-
T
A
M
D
R
E
E
G
L
K
I
G
L
S
D
D
S
N
K
I
--
E
A
---------
I
Y
Y
C
D
S
-
N
Y
D
K
A
Y
D
G
T
V
E
L
L
T
K
Y
---
P
D
I
S
V
M
V
G
---
L
--
N
-
Q
Y
S
A
T
G
A
A
R
A
I
K
D
M
-----
S
LEAK---
V
K
L
V
-
C
I
D
S
S
M
E
Q
---------------
E
G
I
-----
F
E
A
M
V
V
Q
K
P
F
N
I
G
Y
L
G
V
E
K
A
L
K
L
L
K
-
K
E
-
Y
-
V
P
K
Q
L
D
S
G
C
A
L
I
T
-
K
-
D
----------------------------------------------------------------------
27
HHSearch
52.97
12%
-66
- C2 -
1QPZ
1
PURR_ECOLI
A:
[56-305]
-------------------------------------------------
N
H
T
K
S
I
G
L
L
A
-
T
S
--
S
--
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
-
G
-
Y
T
L
--
I
L
G
N
A
W
--
N
N
L
E
K
Q
R
A
Y
--
L
S
M
M
A
-
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
-
E
--
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
-
E
A
--
K
A
D
-
F
T
D
A
V
I
D
N
A
F
E
G
--------
G
Y
M
A
G
R
---
Y
L
I
E
R
-
G
------
H
---
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
---------
I
V
Q
G
D
F
-
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
QP---
H
R
P
T
A
V
F
C
---
G
--
G
-
D
I
M
A
M
G
A
L
C
A
A
D
E
M
-----
G
LRVPQD-
V
S
L
I
-
G
Y
D
N
V
R
N
A
---
R
-----
Y
-----
F
T
P
-----
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
-
N
K
-
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
-
E
-
R
R
S
--
V
A
D
G
P
F
R
D
Y
R
--------------------------------------------------------
31
HHSearch
51.39
12%
-61
- C2 -
3BIL
-
?
A:
[67-308]
-----------------------------------------------------
T
I
G
V
I
V
-
P
S
--
L
--
I
N
H
Y
F
A
A
M
V
T
E
I
Q
S
T
A
S
K
A
-
G
-
L
A
T
--
I
I
T
N
S
N
--
E
D
A
T
T
M
S
G
S
--
L
E
F
L
T
-
S
H
G
V
D
G
I
I
C
V
P
N
E
E
C
-
A
--
N
Q
L
E
D
L
Q
K
-
Q
-
M
P
V
V
L
V
D
R
E
-
L
P
--
G
D--
T
I
P
T
A
T
S
N
P
Q
P
G
--------
I
A
A
A
V
E
---
L
L
A
H
N
-------
N
A
---
L
P
I
G
Y
L
S
G
P
M
D
T
-
S
-
T
G
R
E
R
L
E
D
F
K
A
A
C
A
N
S
K
I
G
E
Q
--
L
---------
V
F
L
G
G
Y
-
E
Q
S
V
G
F
E
G
A
T
K
L
L
D
-----
Q
G
A
K
T
L
F
A
---
G
--
D
-
S
M
M
T
I
G
V
I
E
A
C
H
K
A
-----
G
LVIGKD-
V
S
V
I
-
G
F
D
T
H
P
L
F
---
A
-----
L
-----
Q
P
H
-----
P
L
T
V
I
D
Q
N
V
E
Q
L
A
Q
R
A
V
S
I
L
T
E
L
T
T
-
I
P
-
T
-
A
L
I
H
R
E
S
I
I
N
S
----------------------------------------------------------------------------
29
HHSearch
51.09
11%
-57
- C2 -
3DBI
2
ASCG_ECOLI
A:
[60-309]
--------------------------------------------------
S
T
Q
T
L
G
L
V
V
-
T
N
--
T
L
Y
H
G
I
Y
F
S
E
L
L
F
H
A
A
R
M
A
E
E
K
-
G
-
R
Q
L
--
L
L
A
D
G
K
--
H
S
A
E
E
E
R
Q
A
--
I
Q
Y
L
L
-
D
L
R
C
D
A
I
M
I
Y
P
R
F
L
S
V
D
--
E
I
D
D
I
I
D
A
-
H
S
Q
P
I
M
V
L
N
R
R
-
L
R
--
K
-
N
-
S
S
H
S
V
W
C
D
H
K
Q
T
--------
S
F
N
A
V
A
---
E
L
I
N
A
-------
G
H
---
Q
E
I
A
F
L
T
G
S
M
D
S
-
P
-
T
S
I
E
R
L
A
G
Y
K
D
A
L
A
Q
H
G
I
A
L
N
E
K
L
---------
I
A
N
G
K
W
-
T
P
A
S
G
A
E
G
V
E
M
L
L
E
R
G---
A
K
F
S
A
L
V
A
---
S
--
N
-
D
D
M
A
I
G
A
M
K
A
L
H
E
R
-----
G
VAVPEQ-
V
S
V
I
-
G
F
D
D
I
A
I
A
---
P
-----
Y
-----
T
V
P
-----
A
L
S
S
V
K
I
P
V
T
E
M
I
Q
E
I
I
G
R
L
I
F
M
L
D
-
G
G
-
D
-
F
S
P
P
K
T
F
S
G
K
L
I
R
-
R
-
D
S
L
--
I
A
P
S
--------------------------------------------------------------
21
HHSearch
51.09
11%
-56
- C2 -
2O20
3
?
A:
[62-307]
--------------------------------------------------
R
T
T
T
V
G
V
I
L
-
P
T
--
I
--
T
S
T
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
-
K
-
Y
N
M
--
I
L
A
N
S
D
--
N
D
V
E
K
E
E
K
V
--
L
E
T
F
L
-
S
K
Q
V
D
G
I
V
Y
M
G
S
S
L
D
-
E
--
K
I
R
T
S
L
K
N
-
S
R
T
P
V
V
L
V
G
T
I
-
D
G
--
D
-
K
-
E
I
P
S
V
N
I
D
Y
H
L
A
--------
A
Y
Q
S
T
K
---
K
L
I
D
S
-------
G
N
---
K
K
I
A
Y
I
M
G
S
L
K
D
-
V
-
E
N
T
E
R
M
V
G
Y
Q
E
A
L
L
E
A
N
I
E
F
D
E
N
L
---------
V
F
E
G
N
Y
-
S
Y
E
Q
G
K
A
L
A
E
R
L
L
E
-----
R
G
A
T
S
A
V
V
---
S
--
H
-
D
T
V
A
V
G
L
L
S
A
M
M
D
K
-----
G
VKVPED-
F
E
I
I
-
S
G
A
N
S
P
I
T
---
Q
-----
Y
-----
T
Y
P
-----
T
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
-
K
E
-
D
-
V
E
Q
N
Q
L
V
L
D
H
E
I
F
-
S
-
R
R
S
--
T
K
----------------------------------------------------------------
33
HHSearch
51.05
9%
-61
- C2 -
2FEP
2
CCPA_BACSU
A:
[16-263]
---------------------------------------------------
T
T
T
V
G
V
I
I
-
P
D
---
I
-
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
-
K
-
Y
N
I
--
I
L
S
N
S
D
--
Q
N
M
E
K
E
L
H
L
--
L
N
T
M
L
-
G
K
Q
V
D
G
I
V
F
M
G
G
N
I
T
-
D
--
E
H
V
A
E
F
K
R
-
S
P
V
P
I
V
L
A
A
S
V
-
E
E
--
Q
-
E
-
E
T
P
S
V
A
I
D
Y
E
Q
A
--------
I
Y
D
A
V
K
---
L
L
V
D
K
-
G
------
H
---
T
D
I
A
F
V
S
G
P
M
-
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
N
L
P
F
N
E
Q
F
---------
V
A
E
G
D
Y
-
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
LD---
K
K
P
T
A
I
L
S
---
A
--
T
-
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
-----
G
LSIPED-
L
D
I
I
-
G
F
D
N
T
R
L
S
---
L
-----
M
-----
V
R
P
-----
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
-
K
E
-
P
-
V
E
E
H
I
V
E
L
P
H
R
I
E
-
L
-
R
K
S
--
T
K
----------------------------------------------------------------
20
HHSearch
50.92
8%
-63
- C2 -
3EGC
-
?
A:
[66-312]
--------------------------------------------------
R
S
N
V
V
G
L
I
V
-
S
D
--
I
--
E
N
V
F
F
A
E
V
A
S
G
V
E
S
E
A
R
H
K
-
G
-
Y
S
V
--
L
L
A
N
T
A
--
E
D
I
V
R
E
R
E
A
--
V
G
Q
F
F
-
E
R
R
V
D
G
L
I
L
A
P
S
E
G
E
-
H
--
D
Y
L
R
T
E
L
P
-
K
T
F
P
I
V
A
V
N
R
E
-
L
R
--
I
-
P
-
G
C
G
A
V
L
S
E
N
V
R
G
--------
A
R
T
A
V
E
---
Y
L
I
A
R
-------
G
H
---
T
R
I
G
A
I
V
G
S
A
-
G
L
M
-
T
S
R
E
R
L
K
G
F
R
A
A
M
S
A
A
G
L
P
V
R
Q
E
W
---------
I
A
A
-------
N
G
R
D
G
A
I
K
V
L
T
G----
D
R
P
T
A
L
L
T
---
S
--
S
-
H
R
I
T
E
G
A
M
Q
A
L
N
V
L
-----
G
LRYGPD-
V
E
I
V
-
S
F
D
N
L
P
W
M
---
A
-----
F
-----
L
D
P
-----
P
L
P
V
V
E
Q
P
T
R
R
I
G
Q
E
A
M
R
M
L
I
H
M
I
E
-
G
T
-
G
-
N
A
T
E
M
R
L
Q
T
R
F
V
T
-
H
------------------------------------------------------------------------
37
HHSearch
50.63
13%
-61
- C2 -
3UUG
1
CHVE_AGRFC
A:
[2-276]
--------------------------------------------------
D
K
G
S
V
G
I
A
M
-
P
T
--
K
--
S
S
A
R
W
I
D
D
G
N
N
I
V
K
Q
L
Q
E
A
-
G
-
Y
K
T
--
D
L
Q
Y
A
D
--
D
D
I
P
N
Q
L
S
Q
--
I
E
N
M
V
-
T
K
G
V
K
V
L
V
I
A
S
I
D
G
T
-
T
L
S
D
V
L
K
Q
A
G
E
-
Q
G
I
K
V
I
A
Y
D
R
L
-
I
R
NS
G
-
D
-
V
S
Y
Y
A
T
F
D
N
F
Q
V
--------
G
V
L
Q
A
T
---
S
I
T
D
K
L
G
LKDGK
G
P
---
F
N
I
E
L
F
G
G
S
P
D
D
-
N
-
N
A
F
F
F
Y
D
G
A
M
S
V
L
K
P
Y
I
D
S
G
K
L
V
V
KSGQMGMDK
V
G
T
L
R
W
-
D
P
A
T
A
Q
A
R
M
D
N
L
L
S
A
YYTD
A
K
V
D
A
V
L
S
---
P
--
Y
-
D
G
L
S
I
G
I
I
S
S
L
K
G
V
-----
G
YGTKD
Q
P
L
P
V
V
S
G
Q
D
A
E
V
P
S
V
K
S
I
-----
I
-----
A
G
E
-----
Q
Y
S
T
I
F
K
D
T
R
E
L
A
K
V
T
V
N
M
V
N
A
V
M
E
-
G
K
-
E
-
P
E
V
N
D
T
K
T
Y
E
N
G
V
-
K
-
V
V
P
--
S
Y
L
L
K
P
V
A
V
T
K
E
N
Y
K
Q
V
L
V
D
G
G
Y
Y
K
E
D
Q
L
K
------------------------------------
32
HHSearch
50.40
12%
-74
- C2 -
1DBQ
1
PURR_ECOLI
A:
[8-254]
----------------------------------------------------
K
S
I
G
L
L
A
-
T
S
--
S
--
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
-
G
-
Y
T
L
--
I
L
G
N
A
W
--
N
N
L
E
K
Q
R
A
Y
--
L
S
M
M
A
-
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
-
E
--
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
-
E
A
--
K
A
D
-
F
T
D
A
V
I
D
N
A
F
E
G
--------
G
Y
M
A
G
R
---
Y
L
I
E
R
-
G
------
H
---
R
E
I
G
V
I
P
G
P
--------
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
P
E
S
W
---------
I
V
Q
G
D
F
-
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
QP---
H
R
P
T
A
V
F
C
---
G
--
G
-
D
I
M
A
M
G
A
L
C
A
A
D
E
M
-----
G
LRVPQD-
V
S
L
I
-
G
Y
D
N
V
R
N
A
---
R
-----
Y
-----
F
T
P
-----
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
-
N
K
-
R
-
E
E
P
Q
S
I
E
V
H
P
R
L
I
-
E
-
R
R
S
--
V
A
D
G
P
F
R
D
Y
R
R
-------------------------------------------------------
24
HHSearch
49.86
12%
-60
- C2 -
3BBL
4
?
A:
[3-255]
--------------------------------------------------
L
S
F
M
I
G
Y
S
W
-
T
Q
TE
P
G
Q
V
N
H
I
L
D
Q
F
L
S
S
M
V
R
E
A
G
A
V
-
N
-
Y
F
V
--
L
P
F
P
F
S
--
E
D
-
R
S
Q
I
D
I
--
Y
R
D
L
I
R
S
G
N
V
D
G
F
V
L
S
S
I
N
Y
N
-
D
--
P
R
V
Q
F
L
L
K
-
Q
K
F
P
F
V
A
F
G
R
S
-
N
P
--
D
-
W
-
D
F
A
W
V
D
I
D
G
T
A
G
--------
T
R
Q
A
V
E
---
Y
L
I
G
R
-
G
------
H
---
R
R
I
A
I
L
A
W
P
E
D
S
-
R
-
V
G
N
D
R
L
Q
G
Y
L
E
A
M
Q
T
A
Q
L
P
I
E
T
G
Y
---------
I
L
R
G
E
G
-
T
F
E
V
G
R
A
M
T
L
H
L
L
D
LSPE-
R
R
P
T
A
I
M
T
---
L
--
N
-
D
T
M
A
I
G
A
M
A
A
A
R
E
R
-----
G
LTIGTD-
L
A
I
I
-
G
F
D
D
A
P
M
V
---
Q
-----
Y
-----
L
F
P
-----
P
L
S
S
V
R
Q
P
I
A
E
A
G
R
K
C
I
E
L
L
V
A
I
V
E
-
G
R
-
E
-
P
E
Q
K
H
I
L
L
Q
P
S
L
I
-
I
-
R
A
S
--
E
G
H
H
--------------------------------------------------------------