@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA2691: (2016-02-10 )
MKQRILIVGAGFAGMWSALSAVRQLDRQGRDDVEVAVLAPQPELRIRPRFYEPDVQRMAAPLGELFAAVGVRFVQGSAQRIDVAGKRVEYRDAEGTLAQLDYDRLVLAAGSGVWRPASVAGIDAAFDVDQLEDALRLEAHLHALRDLPDSPARNTVVVAGGGFTGIETATEMPARLRAILGEKAALRVIVVDRGAAIGASMGADLSGLIAEASAELGVEWCLGRSVAAVDAEGVTLDDGQRIEAKTVVWTVGVRASTLTGQIPGERDAQGRLHVDRNLKVLGLDDVYATGDVARAATDDLGNHALMTCQHAIALGRSAGNNVAADLLGVEPIPYSQVKYVTCLDLGGWGAVFTEGWDRQVRFVREEGKKIKTEINGVWIYPPAADRAVALAAADPLIPVVA
Atome Classification :
(20 SA)
---------.........10........20........30........40.....-..-.-50-----.-...-.-----------------.-------..60--------.-----........70-------------..-.-...-...80........90..-.-....----------------.100.......110......--.120.-.---.----.----....130.......140........150..--------.....160..-------------------------.....170.......180-----.-......190.....-..---200-.-.......210.......220.......230-----------------------.----..----..-.--------.240-........250.-----...-.-..260....-...-.270.......280.......290.-------.....-.300---.-.......310.......320.......330....-....340.....-..350..-...----..360.......----------370.......380.....-..390.......400---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------M
K
Q
R
I
L
I
V
GA
G
F
A
G
M
W
S
A
L
S
A
V
R
Q
L
D
RQGRDD
V
E
V
A
V
LAPQP
E
L
R
I
-RP-R-FY-----E-P
D
V
-
Q
-----------------
R
-------
M
A
A
---------
P
-----
L
G
E
L
F
A
A
V
G
--------------
V
R
-
F
-VQG-SA
Q
R
I
DVAGK
R
V
E
YRDA-E-G
T
L
A----------------QLDY
D
R
L
V
L
AAGSGVWRPAS--VAG-I-D---A----A----F
D
V
D
Q
L
E
D
A
L
R
L
E
A
H
L
-
H
A
L
RDLPDSPAR
N
--------
T
V
V
V
AGGGFT-------------------------G
I
E
T
A
TE
M
P
A
R
L
R
A
I
LGE-----K-
A
A
L
R
V
I
V
VDRGAAI-GA---S-M-G-A
D
L
S
G
L
I
A
E
A
S
A
E
L
G
V
E
W
CLGR
S
V
A
A
VDAE-----------------------G----VT----LD-D--------G
Q
R
--
I
E
A
K
T
V
V
W
T
VG
V
-----
R
A
S
-T-LTGQ-IPGE-RDA-Q
G
R
L
H
VDRN
L
K
V
L
GLDDVYATG
D
V
A
-------
R
A
A
T
D
-DL-G---
N
-
H
A
L
M
T
C
Q
H
A
I
A
LGRSAGN
N
V
A
A
D
LLGVE-PIPYS-
Q
V
K
Y
V
T
C
LDLGG-
W
G
A
V
FTE-G
W
D
----
R
Q
V
R
F
V
R
EEG
K
K
----------
I
K
T
EIN
G
V
W
I
YPPAAD
R
A
-
V
A
L
AAADPLIPVVA----------------
1
PsiBlast_PDB
93.97
25%
-107
- C2 -
4NWZ
1
?
A:
[3-343]
----------
K
P
S
I
V
I
L
G
A
G
Y
G
G
I
V
A
A
L
G
L
Q
K
R
L
N
Y
---
N
E
A
D
I
T
L
V
N
K
N
D
Y
H
Y
I
-
T
T
-
E
-
L
H
-----
Q
-
P
A
A
-
G
-----------------
T
-------
M
H
H
---------
D
Q
A
R
VG
I
K
E
L
I
D
E
K
K
--------------
I
K
-
F
-
V
K
D
-
T
V
V
A
I
D
R
E
Q
Q
K
V
T
L
Q
N
G
-
E
----------------------
L
H
Y
D
Y
L
V
V
G
L
G
S
---
E
P
E
T
FG
I
E
G
-
L
R
E
---
H
----
A
----
F
S
I
N
S
I
N
S
V
R
I
I
R
Q
H
I
E
Y
Q
F
A
K
F
A
A
E
P
E
R
T
DYL-----
T
I
V
V
G
G
A
G
F
T
-------------------------
G
I
E
F
V
G
E
L
A
D
R
M
P
E
L
C
A
E
Y
DVD-
P
-
K
L
V
R
I
I
N
V
E
A
A
P
T
V
-
L
P
---
G
-
F
-
D
-
P
A
L
V
N
Y
A
M
D
V
L
G
G
K
G
V
E
F
K
I
G
T
P
I
K
R
C
T
P
E
-----------------------
G
----
V
V
----
I
E
V
D
--------
G
E
E
E
E
I
K
A
A
T
V
V
W
T
G
G
V
-----
R
G
N
-
S
-
I
V
-
E
-
K
S
G
F
-
E
T
M
-
R
G
R
I
K
V
D
P
Y
L
R
A
P
G
H
E
N
I
F
I
V
G
D
C
A
-------
L
I
I
N
E
-
E
N
-
N
---
R
-
P
Y
P
P
T
A
Q
I
A
I
Q
H
G
E
N
V
A
A
N
L
A
A
L
I
R
G
G
S
-
M
T
P
F
K
----------------------------------------------------------------------------------------------------
118
Fugue
85.51
24%
-89
- C2 -
1D7Y
1
?
A:
[5-405]
--------A
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
-----
G
Y
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
-
P
-
L
S
-----
K
-
D
F
M
-
A
-----------------
H
GD-----
A
E
K
---------
I
-----
R
L
D
C
K
R
A
P
E
--------------
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
--
L
Q
G
A
T
-
M
---
P
----
V
----
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
----------
R
P
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
A
R
T
A
---------------
G
V
H
V
S
L
V
E
T
Q
P
R
L
M
S
R
---
A
-
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
-
T
C
P
D
V
Y
A
L
G
D
V
T
-------
R
Q
R
N
P
-
L
S
-
G
---
R
-
F
E
R
I
---
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
T
-
A
P
G
Y
A
-
E
L
P
-
W
Y
W
S
D
Q
G
A
-
L
R
I
Q
V
A
G
-
L
A
S
----
G
D
E
E
I
V
R
G
E
V
S
L
D
A
P
K
F
T
L
I
E
L
Q
K
G
R
I
V
G
A
T
C
V
N
N
A
R
D
F
A
-
P
L
R
R
L
L
A
V
G
A
K
P
D
R
A
A
L
A
DPAT
D
L
R
K
L
A
A
A
93
HHSearch
85.39
20%
-96
- C2 -
3SX6
9
SQRD_ACIF2
A:
[3-420]
---------
G
S
A
H
V
V
I
L
G
A
G
T
G
G
M
P
A
A
Y
E
M
K
E
A
L
G
----
S
G
H
E
V
T
L
I
S
A
N
D
Y
F
Q
F
-
V
P
-
S
-
N
P
-----
W
-
V
G
V
-
G
-----------------
W
KERDD--
I
A
F
---------
P
-----
I
R
H
Y
V
E
R
K
G
--------------
I
H
-
F
-
I
A
Q
-
S
A
E
Q
I
D
A
E
A
Q
N
I
T
L
A
D
------
G
N
----------------
T
V
H
Y
D
Y
L
M
I
A
T
G
P
K
L
A
F
E
-
N
--
V
P
G
-
S
-
D
P--
H
EGP-
V
----
Q
S
I
C
T
V
D
H
A
E
R
A
F
A
E
Y
-
Q
A
L
L
------
R
E
P
--------
G
P
I
V
I
G
A
M
A
G
ASCF
G
P
-------------------
A
Y
E
Y
A
M
I
V
A
S
D
L
K
K
R
-
G
M
-----
R
D
K
I
P
S
F
T
F
I
T
S
E
P
Y
I
-
G
H
LGI
Q
-
G
-
V
-
G
D
S
K
G
I
L
T
K
G
L
K
E
E
G
I
E
A
Y
T
N
C
K
V
T
K
V
E
D
N
-----------------------
K
----
M
Y
V
T
Q
V
D
E
-
K
--------
G
E
T
--
I
K
E
M
V
L
P
V
K
F
G
M
M
I
P
A
F
K
G
V
-
P
-
A
V
A
G
V
E
G
L
--
C
N
P
-
G
G
F
V
L
V
D
E
H
Q
R
S
K
K
Y
A
N
I
F
A
A
G
I
A
I
-------
A
I
P
P
V
-
E
T
-
T
PV
P
T
-
G
A
P
K
T
G
Y
M
I
E
S
M
V
S
A
A
V
H
N
I
K
A
D
L
E
G
R
K
-
G
E
Q
T
M
G
T
W
N
A
V
A
F
A
D
M
G
D
-
R
G
A
A
F
I
A
L
P
Q
L
KPRK
V
D
V
F
A
Y
G
R
W
V
H
L
----------
A
K
V
A
F
E
K
Y
F
I
R
K
M
K
M
G
V
S
E
P
F
Y
E
K
V
L
F
K
---------------------
120
Fugue
83.82
17%
-104
- C2 -
4G9K
1
NDI1_YEAST
A:
[1-471]
M
K
V
I
D
P
Q
HS
D
K
P
N
V
L
I
L
G
S
G
----
W
G
A
I
S
F
L
K
H
I
D
T
---
K
K
Y
N
V
S
I
I
S
P
R
S
Y
F
L
F
-
T
P
-
L
-
L
P
S
A
P
V
G
T
-
V
D
E
-
K
-----------------
S
-------
I
I
E
---------
P
-----
I
V
N
F
A
L
K
K
K
G
N
------------
V
T
-
Y
-
Y
E
A
-
E
A
T
S
I
N
P
D
R
N
T
V
T
I
K
S
L
-
S
-
A
V
S
Q
L
YQPENHLGLHQA
E
P
A
E
I
K
Y
D
Y
L
I
S
A
V
G
A
E
P
-
N
T
F
G
--
I
P
G
-
V
-
T
---
D
Y---
G
----
H
F
L
K
E
I
P
N
S
L
E
I
R
R
T
F
-
A
A
N
L
E
K
A
N
L
L
P
K
G
D
P
E
R
R
R
L
L
S
I
V
V
V
G
G
G
P
T
-------------------------
G
V
E
A
A
G
E
L
Q
D
Y
V
H
Q
D
L
R
K
FL
P
A
L
A
-
E
E
V
Q
I
H
L
V
E
A
L
P
I
V
-
L
N
---
M
-
F
-
E
-
K
K
L
S
S
Y
A
Q
S
H
L
E
N
T
S
I
K
V
H
L
R
T
A
V
A
K
V
E
E
K
-----------------------
Q
----
L
L
----
A
K
-
T
K
H
EDG
K
I
T
E
E
T
--
I
P
Y
G
T
L
I
W
A
T
G
N
K
A
R
P
-
V
I
T
-
D
-
L
F
K
K
-
I
P
E
Q
-
N
S
S
-
K
R
G
L
A
V
N
D
F
L
Q
V
K
G
S
N
N
I
F
A
I
G
D
N
A
FAGLPPT
A
Q
V
A
H
-
Q
E
-
A
---
E
-
Y
L
A
K
N
F
D
K
M
A
Q
I
P
N
F
Q
K
I
D
L
L
F
E
E
N
N
F
K
-
P
F
K
Y
N
-
D
L
G
A
L
A
Y
L
---
G
-
S
E
R
A
I
A
T
-
I
R
S
----
G
K
R
T
F
Y
T
G
G
G
L
M
----------
T
F
Y
L
W
R
I
L
Y
L
S
M
I
L
S
A
R
S
-
R
L
K
V
F
F
D
W
I
K
L
A
F
F
K
R
D
F
F
KGL--------
107
HHSearch
82.08
23%
-101
- C2 -
1M6I
1
AIFM1_HUMAN
A:
[10-372]
---------
S
H
V
P
F
L
L
I
G
G
G
T
A
A
F
A
A
A
R
S
I
R
A
R
D
P
-----
G
A
R
V
L
I
V
S
E
D
P
E
L
P
Y
M
R
P
-
P
-
L
S
-----
K
-
E
L
W
F
S
PNVTKTLRFKQWNG
K
E
R
S
-------
I
Y
F
QPPSFYVSA
Q
-----
D
L
P
H
I
E
N
G
G
--------------
V
A
-
V
-
L
T
G
K
K
V
V
Q
L
D
V
R
D
N
M
V
K
L
N
D
------
G
S
----------------
Q
I
T
Y
E
K
C
L
I
A
T
G
G
T
P
R
S
L
S
A
--
I
D
R
-
A
-
G
A
--
E
V
K
S
R
T
----
T
L
F
R
K
I
G
D
F
R
S
L
E
K
I
S
----------
R
E
V
K
--------
S
I
T
I
I
G
G
G
F
L
-------------------------
G
S
E
L
A
C
A
L
G
R
K
A
R
A
-----------
L
G
T
E
V
I
Q
L
F
P
E
K
G
N
-
M
G
K--
I
-
L
-
P
-
E
Y
L
S
N
W
T
M
E
K
V
R
R
E
G
V
K
V
M
P
N
A
I
V
Q
S
V
G
V
S
SG
K
L
-------------------
L
----
I
K
----
L
K
-
D
--------
G
R
K
--
V
E
T
D
H
I
V
A
A
V
G
L
-----
E
P
N
-
V
E
L
A
K
T
-
G
G
L
E
-
I
D
S
D
F
G
G
F
R
V
N
A
E
L
Q
A
--
R
S
N
I
W
V
A
G
D
A
A
-------
C
F
Y
D
I
-
K
L
-
G
---
R
-
R
R
V
E
H
H
D
H
A
V
V
S
G
R
L
A
G
E
N
M
T
G
A
---------------------------------------------------------------------------------------------------------------
102
HHSearch
80.26
24%
-113
- C2 -
1XHC
1
?
A:
[9-301]
-----------
S
K
V
V
I
V
G
N
G
P
G
G
F
E
L
A
K
Q
L
S
Q
--------
T
Y
E
V
T
V
I
D
K
E
P
V
P
Y
Y
S
K
P
-
M
-
L
S
-----
H
-
Y
I
A
-
G
-----------------
F
IP
R
N
R
--
L
F
P
---------
Y
-----
S
L
D
W
Y
R
K
R
G
--------------
I
E
-
I
-
R
L
A
E
E
A
K
L
I
D
R
G
R
K
V
V
I
T
E
-------
K
G
----------------
E
V
P
Y
D
T
L
V
L
A
T
G
A
R
A
R
E
P
-
Q
--
I
K
G
-
K
-
E
---
Y
----
L
----
L
T
L
R
T
I
F
D
A
D
R
I
K
E
S
I
-
E
---------
N
S
G
--------
E
A
I
I
I
G
G
G
F
I
-------------------------
G
L
E
L
A
G
N
L
A
E
A
G
---------------
Y
H
V
K
L
I
H
R
G
A
M
F
-
L
----
G
-
L
-
D
-
E
E
L
S
N
M
I
K
D
M
L
E
E
T
G
V
K
F
F
L
N
S
E
L
L
E
A
N
E
E
-----------------------
G
----
V
L
-----
T
-
N
--------
S
G
F
--
I
E
G
K
V
K
I
C
A
I
G
I
-----
V
P
N
V
D
-
L
A
R
R
-
S
G
I
H
-
T
G
--
R
G
-
I
L
I
D
D
N
F
R
T
-
S
A
K
D
V
Y
A
I
G
D
C
A
-------
E
Y
S
G
-----------
I
I
A
G
T
A
K
A
A
M
E
Q
A
R
V
L
A
D
I
L
K
G
----------------------------------------------------------------------------------------------------------------
94
HHSearch
80.25
18%
-107
- C2 -
3H8L
7
SQRD_ACIAM
A:
[2-357]
-----------
T
K
V
L
V
L
G
G
R
F
G
A
L
T
A
A
Y
T
L
K
R
L
V
G
----
S
K
A
D
V
K
V
I
N
K
S
R
F
S
Y
F
-
R
P
-
A
-
L
P
-----
H
-
V
A
I
-
G
-----------------
V
R
D
V
D
E
--
L
K
V
---------
D
-----
L
S
E
A
L
P
E
K
G
--------------
I
Q
-
F
-
Q
E
G
-
T
V
E
K
I
D
A
K
S
S
M
V
Y
Y
T
K
P
-
D
-
G
S
M
A
----------------
E
E
E
Y
D
Y
V
I
V
G
I
G
A
H
L
A
T
E
-
L
--
V
K
G
-
W
-
D
K--
Y
----
G
----
Y
S
V
C
E
P
E
F
A
T
K
L
R
E
K
L
-
E
S
F
-------
Q
G
G
--------
N
I
A
I
-
G
S
G
P
F
YQGHNPKPKVPENF
V
P
N
A
DSACE
G
P
V
F
E
M
S
L
M
L
H
G
Y
F
K
K
-
K
G
M
-----
L
-
D
K
V
H
V
T
V
F
S
P
G
E
-
Y
-
L
S
---
D
-
L
-
S
-
P
N
S
R
K
A
V
A
S
I
Y
N
Q
L
G
I
K
L
V
H
N
F
K
I
K
E
I
R
E
H
-----------------------
E
----
I
V
----
D
E
-
K
--------
G
N
T
--
I
P
A
D
I
T
I
L
L
P
P
Y
-----
T
G
N
-
P
-
A
L
K
N
-
S
T
P
D
L
V
D
D
-
G
G
F
I
P
T
D
L
N
M
V
S
I
K
Y
D
N
V
Y
A
V
G
D
A
N
-------
S
M
T
V
-------------
P
K
L
G
Y
L
A
V
M
T
G
R
I
A
A
Q
H
L
A
N
R
L
G
V
P
T
K
V
D
K
Y
Y
--
P
T
I
V
C
V
A
D
N
P
Y
E--------------------------------------------------------------------------------------
108
HHSearch
79.60
23%
-108
- C2 -
3FG2
2
?
P:
[1-310]
----------
N
D
T
V
L
I
A
G
A
G
H
A
G
F
Q
V
A
V
S
L
R
Q
A
K
Y
-----
P
G
R
I
A
L
I
N
D
E
K
H
L
P
Y
-
Q
R
-
P
P
L
S
-----
K
A
Y
L
K
-
S
GGDPN------------
S
-------
L
M
F
---------
R
-----
P
E
K
F
F
Q
D
Q
A
--------------
I
E
-
L
-
I
S
D
-
R
M
V
S
I
D
R
E
G
R
K
L
L
L
A
S
------
G
T
----------------
A
I
E
Y
G
H
L
V
L
A
T
G
A
R
N
R
M
L
-
D
--
V
P
N
-
A
-
S
LP-
D
----
V
----
L
Y
L
R
T
L
D
E
S
E
V
L
R
Q
R
M
----------
P
D
K
K
--------
H
V
V
V
I
G
A
G
F
I
-------------------------
G
L
E
F
A
A
T
A
R
A
K
G
---------------
L
E
V
D
V
V
E
L
A
P
R
V
-
M
A
---
R
V
V
-
T
-
P
E
I
S
S
Y
F
H
D
R
H
S
G
A
G
I
R
M
H
Y
G
V
R
A
T
E
I
A
A
E
GDRVT------------------
G
----
V
V
----
L
S
-
D
--------
G
N
T
--
L
P
C
D
L
V
V
V
G
V
G
V
-----
I
P
N
V
E
-
I
A
A
A
-
A
G
L
P
-
T
---
A
A
G
I
I
V
D
Q
Q
L
L
T
-
S
D
P
H
I
S
A
I
G
D
C
A
-------
L
F
E
S
V
-
R
F
-
G
---
E
T
M
R
V
E
S
V
Q
N
A
T
D
Q
A
R
C
V
A
A
R
L
T
G
D
---------------------------------------------------------------------------------------------------------------
104
HHSearch
77.54
22%
-98
- C2 -
3CGB
2
?
A:
[37-353]
-----------
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
I
V
R
N
D
E
-----
N
A
N
V
V
T
L
E
K
G
E
I
Y
S
Y
A
Q
C
-
G
-
L
P
-----
Y
-
V
I
S
-
G
-----------------
A
IASTEKL
I
A
R
---------
N
-----
V
K
T
F
R
D
K
Y
G
--------------
I
D
-
A
K
V
R
H
-
E
V
T
K
V
D
T
E
K
K
I
V
Y
A
E
H
T
K
T
-
K
D
V
F
----------------
E
F
S
Y
D
R
L
L
I
A
T
G
V
R
P
V
M
P
-
E
--
W
E
G
-
R
-
D
LQ-
G
----
V
----
H
L
L
K
T
I
P
D
A
E
R
I
L
K
T
L
-
E
T
-------
N
K
V
E
--------
D
V
T
I
I
G
G
G
A
I
-------------------------
G
L
E
M
A
E
T
F
V
E
L
G
---------------
K
K
V
R
M
I
E
R
N
D
H
I
-
G
T
---
I
-
Y
-
D
-
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
H
I
E
I
L
T
N
E
N
V
K
A
F
K
G
N
-----------------------
E
RVE-
A
V
----
E
T
-
D
--------
K
G
T
--
Y
K
A
D
L
V
L
V
S
V
G
V
-----
K
P
N
T
D
-
F
L
E
G
-
T
N
I
R
-
T
N
H
-
K
G
A
I
E
V
N
A
Y
M
Q
T
-
N
V
Q
D
V
Y
A
A
G
D
C
A
-------
T
H
Y
H
V
-
I
K
E
I
---
H
-
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
K
---------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.11
28%
-99
- C2 -
4H4X
9
?
A:
[6-276]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
-
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
----
I
T
V
V
G
D
E
A
E
----
R
P
---
Y
D
-----
R
-
P
-----------------------------------------
P
-----
L
S
K
D
F
M
A
H
G
DAEKIRLDCKRAPE
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
---
P
R
A
--
L
P
T
-
L
-
Q
---
G
----
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
P
---------
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
---------
A
R
-----
T
-
A
G
V
H
V
S
L
V
A
R
G
P
R
L
-
M
S
R--
A
-
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
T
-
C
P
D
V
Y
A
L
G
D
V
T
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
77.06
21%
-100
- C2 -
3NTD
2
?
A:
[1-338]
----------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
A
R
R
L
S
E
-----
T
A
E
I
I
M
F
E
R
G
E
Y
V
S
F
-
A
N
C
G
-
L
P
-----
Y
-
H
I
S
-
G
-----------------
E
IAQ
R
S
A
L
V
L
Q
---------
T
-----
P
E
S
F
K
A
R
F
N
--------------
V
E
-
V
R
V
K
H
-
E
V
V
A
I
D
R
A
A
K
L
V
T
V
R
R
L
L
D
-
G
S
E
Y
----------------
Q
E
S
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
-
P
--
I
P
G
-
V
-
D
NP-
L
----
T
----
H
S
L
R
N
I
P
D
M
D
R
I
L
Q
T
I
-
Q
M
-------
N
N
V
E
--------
H
A
T
V
V
G
G
G
F
I
-------------------------
G
L
E
M
M
E
S
L
H
H
L
G
---------------
I
K
T
T
L
L
E
L
A
D
Q
V
-
M
T
---
P
-
V
-
D
-
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
G
V
D
L
R
L
G
T
A
L
S
E
V
S
Y
Q
V
QT
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
----
L
T
----
L
S
-
N
--------
G
E
L
--
L
E
T
D
L
L
I
M
A
I
G
V
-----
R
P
E
T
Q
-
L
A
R
D
-
A
G
L
A
-
I
G
E
-
L
G
G
I
K
V
N
A
M
M
Q
T
-
S
D
P
A
I
Y
A
V
G
D
A
V
-------
E
E
Q
D
F
-
V
T
-
G
Q
--
A
-
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
---------------------------------------------------------------------------------------------------------------
110
HHSearch
76.76
25%
-95
- C2 -
3IWA
1
?
A:
[4-348]
-----------
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
F
K
R
L
D
P
-----
E
A
H
V
T
M
I
D
Q
A
-------------------------------------------------------------------------------------------
V
E
A
L
-
V
E
T
-
R
A
H
A
I
D
R
A
A
H
T
V
E
I
E
N
L
R
T
-
G
E
R
R
----------------
T
L
K
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
P
-
P
--
V
E
G
-
M
-
D
LA-
G
----
V
----
T
P
V
T
N
L
D
E
A
E
F
V
Q
H
A
I
-
S
A
-------
G
E
V
S
--------
K
A
V
I
V
G
G
G
F
I
-------------------------
G
L
E
M
A
V
S
L
A
D
M
W
G
--------------
I
D
T
T
V
V
E
L
A
D
Q
I
-
M
P
---
G
-
F
T
S
-
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
D
V
V
V
H
T
G
E
K
V
V
R
L
E
G
E
-----------------------
N
GKVA
R
V
----
I
T
-
D
--------
K
R
T
--
L
D
A
D
L
V
I
L
A
A
G
V
-----
S
P
N
T
Q
-
L
A
R
D
-
A
G
L
E
-
L
D
P
-
R
G
A
I
I
V
D
T
R
M
R
T
-
S
D
P
D
I
F
A
G
G
D
C
V
-------
T
I
P
N
L
-
V
T
-
G
K
--
P
-
G
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
G
---------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.52
28%
-98
- C2 -
4H4Y
9
?
A:
[6-276]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
-
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
----
I
T
V
V
G
D
E
A
E
----
R
P
---
Y
D
-----
R
-
P
-----------------------------------------
P
-----
L
S
K
D
F
M
A
H
G
DAEKIRLDCKRAPE
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
---
P
R
A
--
L
P
T
-
L
-
Q
---
G
----
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
P
---------
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
---------
A
R
-----
T
-
A
G
V
H
V
S
L
V
A
R
G
P
R
L
-
M
S
R--
A
-
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
T
-
C
P
D
V
Y
A
L
G
D
V
T
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
105
HHSearch
76.09
20%
-94
- C2 -
1NHP
3
NAPE_ENTFA
A:
[1-316]
-----------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
L
L
N
L
H
P
-----
D
A
E
I
Q
W
Y
E
K
G
D
F
I
S
F
-
L
S
-
A
G
M
Q
-----
L
-
Y
L
E
-
G
-----------------
K
VKDVNS-
V
R
Y
---------
M
-----
T
G
E
K
M
E
S
R
G
--------------
V
N
-
V
-
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
V
K
D
L
V
S
-
G
E
E
R
----------------
V
E
N
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
-
D
--
I
P
G
-
K
-
D
LD-
N
----
I
----
Y
L
M
R
G
R
Q
W
A
I
K
L
K
Q
K
T
-
V
D
-------
P
E
V
N
--------
N
V
V
V
I
G
S
G
Y
I
-------------------------
G
I
E
A
A
E
A
F
A
K
A
G
---------------
K
K
V
T
V
I
D
I
L
D
R
P
-
L
G
V--
Y
-
L
-
D
-
K
E
F
T
D
V
L
T
E
E
M
E
A
N
N
I
T
I
A
T
G
E
T
V
E
R
Y
E
G
D
-----------------------
G
RVQ-
K
V
----
V
T
-
D
--------
K
N
A
--
Y
D
A
D
L
V
V
V
A
V
G
V
-----
R
P
N
-
T
A
W
L
K
--
G
T
L
E
-
L
H
P
-
N
G
L
I
K
T
D
E
Y
M
R
T
-
S
E
P
D
V
F
A
V
G
D
A
T
-------
L
I
K
Y
N
P
A
D
-
T
---
E
-
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
---------------------------------------------------------------------------------------------------------------
97
HHSearch
75.97
26%
-104
* C2 *
2GQW
5
?
A:
[6-308]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
S
F
V
A
E
L
R
Q
A
G
Y
-----
Q
G
L
I
T
V
V
G
D
E
A
E
R
P
Y
D
R
P
-
P
-
L
S
-----
K
-
D
F
M
-
A
-----------------
H
G------
D
A
E
---------
K
I----
R
L
D
C
K
R
A
P
E
--------------
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
------
G
R
----------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
P
R
A
L
P
T
--
L
Q
G
-
A
-
T
M
--
P
----
V
----
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
---------
P
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
A
R
T
A
G
---------------
V
H
V
S
L
V
E
T
Q
P
R
L
-
M
S
---
R
A
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
A
L
A
R
A
-
A
G
L
A
-
C
---
D
D
G
I
F
V
D
A
Y
G
R
T
-
T
C
P
D
V
Y
A
L
G
D
V
T
-------
R
Q
R
N
P
-
L
S
-
G
---
R
F
E
R
I
E
T
W
S
N
A
Q
N
Q
G
I
A
V
A
R
H
L
V
D
P
---------------------------------------------------------------------------------------------------------------
111
HHSearch
75.82
26%
-99
- C2 -
3LXD
1
?
A:
[9-321]
----------
R
A
D
V
V
I
V
G
A
G
H
G
G
A
Q
A
A
I
A
L
R
Q
N
G
F
-----
E
G
R
V
L
V
I
G
R
E
P
E
I
P
Y
-
E
R
P
P
L
S
K
-----
E
-
Y
L
A
-
R
-----------------
E
KTFER--
I
C
I
---------
R
-----
P
A
Q
F
W
E
D
K
A
--------------
V
E
-
M
-
K
L
G
A
E
V
V
S
L
D
P
A
A
H
T
V
K
L
G
D
------
G
S
----------------
A
I
E
Y
G
K
L
I
W
A
T
G
G
D
P
R
R
L
-
S
--
C
V
G
-
A
-
D
L
A
-
G
----
V
----
H
A
V
R
T
K
E
D
A
D
R
L
M
A
E
L
-
D
--------
A
G
A
K
--------
N
A
V
V
I
G
G
G
Y
I
-------------------------
G
L
E
A
A
A
V
L
T
K
F
G
---------------
V
N
V
T
L
L
E
A
L
P
R
V
-
L
A
---
R
-
V
A
G
-
E
A
L
S
E
F
Y
Q
A
E
H
R
A
H
G
V
D
L
R
T
G
A
A
M
D
C
I
E
G
D
GTKVT------------------
G
----
V
R
----
M
Q
-
D
--------
G
S
V
--
I
P
A
D
I
V
I
V
G
I
G
I
-----
V
P
C
-
V
G
A
L
I
S
-
A
G
A
S
---
G
-
G
N
G
V
D
V
D
E
F
C
R
T
-
S
L
T
D
V
Y
A
I
G
D
C
A
-------
A
H
A
N
D
F
A
D
-
G
A
--
V
-
I
R
L
E
S
V
Q
N
A
N
D
M
A
T
A
A
A
K
D
I
C
G
A
---------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.60
28%
-100
- C2 -
4H50
8
?
A:
[6-276]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
-
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
----
I
T
V
V
G
D
E
A
E
----
R
P
---
Y
D
-----
R
-
P
-----------------------------------------
P
-----
L
S
K
D
F
M
A
H
G
DAEKIRLDCKRAPE
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
---
P
R
A
--
L
P
T
-
L
-
Q
---
G
----
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
P
---------
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
---------
A
R
-----
T
-
A
G
V
H
V
S
L
V
Q
R
G
P
R
L
-
M
S
R--
A
-
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
T
-
C
P
D
V
Y
A
L
G
D
V
T
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
75.35
18%
-107
- C2 -
3ICS
2
?
A:
[36-353]
----------
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
L
R
R
L
S
E
-----
E
D
E
I
I
M
V
E
R
G
E
Y
I
S
F
-
A
N
C
G
-
L
P
-----
Y
-
Y
I
G
-
G
-----------------
V
ITERQKL
L
V
Q
---------
T
-----
V
E
R
M
S
K
R
F
N
--------------
L
D
-
I
R
V
L
S
-
E
V
V
K
I
N
K
E
E
K
T
I
T
I
K
N
V
-
T
T
N
E
T
Y
----------------
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
-
S
--
I
P
G
-
I
-
E
EAK
A
----
L
----
F
T
L
R
N
V
P
D
T
D
R
I
K
A
Y
I
-
D
E
-------
K
K
P
R
--------
H
A
T
V
I
G
G
G
F
I
-------------------------
G
V
E
M
V
E
N
L
R
E
R
G
---------------
I
E
V
T
L
V
E
M
A
N
Q
V
-
M
P
---
P
-
I
-
D
-
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
D
V
E
L
V
F
E
D
G
V
D
A
L
E
E
N
GA---------------------
V
----
V
R
----
L
K
-
S
--------
G
S
V
--
I
Q
T
D
M
L
I
L
A
I
G
V
-----
Q
P
E
-
S
S
L
A
K
G
-
A
G
L
A
-
L
G
V
-
R
G
T
I
K
V
N
E
K
F
Q
T
-
S
D
P
H
I
Y
A
I
G
D
A
I
-------
E
V
K
D
F
-
V
T
-
E
T
--
E
-
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
---------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.25
27%
-97
- C2 -
4H4U
9
?
A:
[6-276]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
-
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
----
I
T
V
V
G
D
E
A
E
----
R
P
---
Y
D
-----
R
-
P
-----------------------------------------
P
-----
L
S
K
D
F
M
A
H
G
DAEK
I
R
L
D
CKRAPE
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
---
P
R
A
--
L
P
T
-
L
-
Q
---
G
----
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
P
---------
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
---------
A
R
-----
T
-
A
G
V
H
V
S
L
V
E
R
Q
P
R
L
-
M
S
---
R
-
A
-
A
P
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
T
-
C
P
D
V
Y
A
L
G
D
V
T
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.24
28%
-98
- C2 -
4H4W
5
?
A:
[6-276]
---------
L
K
A
P
V
V
V
L
G
A
G
L
A
S
V
-
S
F
V
A
E
L
R
Q
A
G
Y
Q
G
L
----
I
T
V
V
G
D
E
A
E
----
R
P
---
Y
D
-----
R
-
P
-----------------------------------------
P
-----
L
S
K
D
F
M
A
H
G
DAEKIRLDCKRAPE
V
E
-
W
-
L
L
G
V
T
A
Q
S
F
D
P
Q
A
H
T
V
A
L
S
D
G
-
R
---------------------
T
L
P
Y
G
T
L
V
L
A
T
G
A
A
---
P
R
A
--
L
P
T
-
L
-
Q
---
G
----
A
T
M
P
V
H
T
L
R
T
L
E
D
A
R
R
I
Q
A
G
L
-
R
P
---------
Q
S
--------
R
L
L
I
V
G
G
G
V
I
-------------------------
G
L
E
L
A
A
T
---------
A
R
-----
T
-
A
G
V
H
V
S
L
V
C
R
G
P
R
L
-
M
S
R--
A
-
A
-
P
-
A
T
L
A
D
F
V
A
R
Y
H
A
A
Q
G
V
D
L
R
F
E
R
S
V
T
G
S
V
D
G
-----------------------
V
----
V
L
----
L
D
-
D
--------
G
T
R
--
I
A
A
D
M
V
V
V
G
I
G
V
-----
L
A
N
-
D
-
A
L
A
R
-
A
A
G
L
-
A
C
D
-
D
G
-
I
F
V
D
A
Y
G
R
T
T
-
C
P
D
V
Y
A
L
G
D
V
T
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------