@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA4505: (2016-02-28 )
MSLLDIKNLSVRFGDTTAVPVVDGLDLSVDKGEVLAIVGESGSGKSVTMMALMGLIDAPGWVSADHLRFDGHDMLTLKGRQRRRIVGKDMAMVFQDPMTALNPSYTVGYQIEEVLRLHLGLRGKALRQRALELLERVEIPAAASRLDAYPHQLSGGMSQRVAIAMAIAAEPKLLIADEPTTALDVTIQAQIMELLLNLQRDQDMALILITHDLAVVAETAQRVCVMYAGEAVEIGGVPALFDRPTHPYTEALIKAIPEHCAGEARLATLPGIVPGRYDRPRGCLLSPRCPYAQEHCRQERPALETHERGAVRCFYPLNLLNEVA
Atome Classification :
(44 SA)
.........10...-.-.-...20.-.......30........40........50.......-.--60........70.......----.80--------.......---..90....---....100.......110.--.----.....120..--....--.130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250...-----....260.......270------------........280.......290.......300.......310.......320..--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
L
L
DIK
N
L
S
V
R
FG-D-
T
-
T
A
V
P
V
V-DGLDLSVDKG
E
V
L
A
I
V
GESGSG
K
S
V
T
M
M
A
L
M
G
L
IDA-P--GWVSA
D
H
LRFDGH
D
M
L
T
LK----GR---------
Q
R
R
R
I
VG---
K
D
M
A
M
V
F
Q---D
P
M
T
ALNPSYTV
G
Y
Q
I
E
E
--
V
----
L
R
L
H
LGL
R
G
K
--
A
L
R
Q
--
R
A
L
E
L
L
E
RVEIP
A
A
A
S
R
LDAY
P
H
Q
LSGGMS
Q
R
V
A
I
A
M
A
IAAE
P
K
L
L
I
ADEPT
T
A
L
D
V
T
I
Q
A
Q
I
M
E
L
L
L
N
LQRDQ
D
M
A
L
I
L
I
TH
D
L
A
V
V
A
E
T
A
Q
R
V
C
V
M
YAG
E
A
V
EIGGV
P
A
LFDRPTH
P
Y
T
E
A
L
I
K
A
-----
I
P
E
HCAGEA
R
L
ATLPG-------------IVPGRYDRPRGCLLSPRCP
Y
A
Q
E
H
C
R
QERPALETHERG
A
V
R
C
F
Y
P
L
N
L
L
N
EVA--------------
1
PsiBlast_PDB
84.95
39%
-119
- C1 -
4FWI
3
?
B:
[16-303]
----------
V
R
E
G
-
T
-
I
-
K
A
A
----
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
-
N
--
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
----
E
E
---------
E
L
R
K
I
R
W
---
K
E
I
A
L
V
P
Q
---
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
--
T
----
V
E
A
H
-
G
V
R
W
S
HS
E
L
I
E
--
K
A
S
E
K
L
R
M
V
R
L
N
P
E
A
V
-
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
-----
I
M
----------
P
I
P
G
-------------
D
P
P
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
-------------------------------------
13
PsiBlast_PDB
81.87
31%
-139
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
38
PsiBlast_CBE
81.60
31%
-131
- C1 -
3TUI
1
METN_ECOLI
G:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.39
36%
-135
- C1 -
4U02
1
?
A:
[4-243]
--
I
I
R
I
R
N
L
H
K
W
F
G
------
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
D
G
---
L
S
V
K
----
D
D
---------
R
A
L
R
E
I
R
---
R
E
V
G
M
V
F
Q
---
Q
--
F
N
L
F
P
H
M
T
V
---
L
E
N
--
V
T
LAP
M
R
V
R
R
W
P
R
E
K
--
A
-
E
K
--
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
V
L
H
---------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.10
36%
-135
- C1 -
4U00
3
?
A:
[4-243]
--
I
I
R
I
R
N
L
H
K
W
F
G
------
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
D
G
---
L
S
V
K
----
D
D
---------
R
A
L
R
E
I
R
---
R
E
V
G
M
V
F
Q
---
Q
--
F
N
L
F
P
H
M
T
V
---
L
E
N
--
V
T
L
A
P
M
R
V
R
R
W
P
R
E
K
--
A
-
E
K
--
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
V
L
H
---------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.98
31%
-132
- C1 -
3TUI
1
METN_ECOLI
C:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
35
PsiBlast_CBE
78.96
31%
-134
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.81
36%
-137
- C1 -
4U02
1
?
C:
[4-243]
--
I
I
R
I
R
N
L
H
K
W
F
G
------
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
D
G
---
L
S
V
K
----
D
D
---------
R
A
L
R
E
I
R
---
R
E
V
G
M
V
F
Q
---
Q
--
F
N
L
F
P
H
M
T
V
---
L
E
N
--
V
TLAP
M
R
V
R
R
W
P
R
E
K
--
A
-
E
K
--
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
V
L
H
---------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.73
33%
-131
- C1 -
3C41
3
?
K:
[1-241]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
-----
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
36
PsiBlast_CBE
78.35
31%
-136
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.34
36%
-137
- C1 -
4U02
1
?
B:
[4-243]
--
I
I
R
I
R
N
L
H
K
W
F
G
------
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
D
G
---
L
S
V
K
----
D
D
---------
R
A
L
R
E
I
R
---
R
E
V
G
M
V
F
Q
---
Q
--
F
N
L
F
P
H
M
T
V
---
L
E
N
--
V
TLAP
M
R
V
R
R
W
P
R
E
K
--
A
-
E
K
--
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
V
L
H
---------------------------------------------------------------------------------------------
39
PsiBlast_CBE
78.21
31%
-129
- C1 -
3TUI
1
METN_ECOLI
D:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
85
HHSearch
78.14
30%
-129
* C1 *
3TUI
1
METN_ECOLI
C:
[23-266]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
-
G
T
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-------
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----
E
S
---------
E
L
T
K
-
A
R
---
R
Q
I
G
M
I
F
Q
---
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
-
T
P
K
D
--
E
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
G
---
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-----------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.46
31%
-134
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-274]
--
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
G
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
ESEL
T
K
---------
A
R
R
Q
I
--------
G
M
I
F
Q
---
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
N
T
P
K
D
E
---
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
---
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLD
I
P
E
---------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.88
36%
-132
- C1 -
4U02
1
?
D:
[4-243]
--
I
I
R
I
R
N
L
H
K
W
F
G
------
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
-------
F
Q
E
G
E
V
V
V
D
G
---
L
S
V
K
----
D
D
---------
R
A
L
R
E
I
R
---
R
E
V
G
M
V
F
Q
---
Q
--
F
N
L
F
P
H
M
T
V
---
L
E
N
--
V
TLAP
M
R
V
R
R
W
P
R
E
K
--
A
-
E
K
--
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
---
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
-----
V
L
H
---------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.85
33%
-131
- C1 -
3C4J
4
?
B:
[22-262]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
---
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
104
Fugue
76.72
26%
-120
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
-
T
-
R
T
I
Q
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
-
T
L
I
R
C
V
N
L
L
E
R
-
P
-----
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
----
E
S
---------
E
L
T
K
A
R
R
---
Q
-
I
G
M
I
F
Q
---
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
--
P
----
L
E
L
D
-
N
T
P
K
D
--
E
V
K
R
--
R
V
T
E
L
L
S
L
V
G
L
G
---
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-----
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
EPFTDCVPMLRLE
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
AIAWLQEHHVKVEV
99
HHSearch
76.59
30%
-131
- C1 -
1B0U
4
HISP_SALTY
A:
[5-255]
-
N
K
L
H
V
I
D
L
H
K
R
Y
G
-
G
-----
H
E
V
L
-
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-------
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
----
D
K
DGQLKVAD
K
N
Q
L
R
L
L
R
---
T
R
L
T
M
V
F
Q
---
H
F
N
--
L
W
S
H
M
T
V
L
E
N
V
M
E
--
A
----
P
I
Q
V
L
G
L
S
K
H
--
D
A
R
E
--
R
A
L
K
Y
L
A
K
V
G
I
D
E
--
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
-----------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.39
33%
-127
- C1 -
3C4J
3
?
A:
[22-262]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
---
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.94
33%
-125
- C1 -
2Q0H
4
?
A:
[23-262]
-
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
---
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P
---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.27
33%
-128
- C1 -
2OLK
2
?
B:
[22-262]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
---
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.49
33%
-127
- C1 -
2OLK
1
?
D:
[22-262]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
------
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
I
I
D
G
I
N
L
K
A
K
D
T
N
L
N
K
----
V
R
---------
E
----------
E
V
G
M
V
F
Q
---
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
--
A
P---
M
K
V
R
K
W
P
R
E
K
--
A
-
E
A
--
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
---
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
-----
V
-----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.58
31%
-128
- C1 -
1VCI
1
?
A:
[10-253]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
-
N
-
F
-
T
A
V
----
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
-
E
E
-
P
-----
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
L
P
----
P
K
---------
D
R
---------
N
I
S
M
V
F
Q
-----------
H
M
T
V
Y
E
N
I
A
F
--
P
----
L
--
K
K
F
P
K
D
E
--
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
------
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
------
P
E
---------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.38
34%
-118
- C1 -
1L2T
4
Y796_METJA
A:
[23-222]
---------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
-
T
M
L
N
I
I
G
C
L
D
K
-
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
----
K
I
---------
R
R
D
K
I
--------
G
F
V
F
Q
-----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PL
I
----
F
K
Y
R
G
A
M
S
G
E
--
E
R
R
K
--
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
--
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
56.43
34%
-118
- C1 -
1L2T
4
Y796_METJA
B:
[23-222]
---------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
-
T
M
L
N
I
I
G
C
L
D
K
-
P
TE
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
----
K
I
---------
R
R
D
K
I
--------
G
F
V
F
Q
-----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PL
I
----
F
K
Y
R
G
A
M
S
G
E
--
E
R
R
K
--
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
--
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
56.35
34%
-125
- C1 -
3TIF
6
Y796_METJA
B:
[23-222]
---------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
-
T
M
L
N
I
I
G
C
L
D
K
-
P
TE
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
----
K
I
---------
R
R
D
K
I
--------
G
F
V
F
Q
-----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PL
I
----
F
K
Y
R
G
A
M
S
G
E
--
E
R
R
K
--
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
--
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.94
34%
-120
- C1 -
3TIF
7
Y796_METJA
A:
[23-222]
---------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
-
T
M
L
N
I
I
G
C
L
D
K
-
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
----
K
I
---------
R
R
D
K
I
--------
G
F
V
F
Q
-----
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PL
I
----
F
K
Y
R
G
A
M
S
G
E
--
E
R
R
K
--
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
--
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
55.17
31%
-106
- C1 -
2FGK
2
D:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
54.03
31%
-108
- C1 -
2FGJ
2
D:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
53.94
31%
-107
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
53.42
31%
-107
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[1-233]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
53.21
31%
-106
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
53.08
31%
-108
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
52.96
31%
-105
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
51.80
31%
-104
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[1-233]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
51.48
31%
-107
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
51.45
31%
-103
- C1 -
2FFA
2
A:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
51.14
31%
-108
- C1 -
1XEF
3
D:
[1-233]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.66
31%
-105
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[1-233]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
50.21
31%
-106
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
SII
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
48.95
31%
-105
- C1 -
2PMK
1
A:
[3-235]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
48.84
31%
-101
- C1 -
2FFB
1
A:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
48.21
31%
-103
- C1 -
3B5J
1
A:
[3-235]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
48.03
31%
-105
- C1 -
2FF7
1
A:
[7-239]
----
D
I
T
F
R
N
I
R
F
R
-
Y
-
K
-
P
D
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
-
T
L
T
K
L
I
Q
R
F
Y
I
-
P
-----
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
----
P
N
---------
W
L
R
R
Q
V
G
VVL
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
P
----
G
M
S
V
E
K
--
V
----
I
---
Y
A
A
K
L
A
--
G
A
H
D
--
F
I
S
E
L
R
E
-----
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
-
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-----------------------------------------------------------------------------------------------------------