@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0130: (2016-03-12 )
VKVNKFFKKTTHVLLVAGLTIGLTAPFTGTTAQAAADTVPIQILGINDFHGALETASKDASGSPIGGADYLATNLDNATNSFLQANPGATTDNAIRVQAGDMVGASPAVSGLLQDEPTMKVLQKMNFEVGTLGNHEFDEGLPEYKRILDGVSTNKFGPIVEAYPRVKSDMKIVAANVVNKGTNTVAEGFLPYYVKEIDGVKVGFIGIVTTEIPNLVLANHIKDYDFLDEAETIVKYSAELRGQGVNAIVVLSHVPALSTGNPNTGTKQDVAGEAANMMTKANELDPNNSVDLVLAGHNHQYTNGLVGKTRIVQSYNNGKAFSDVTGELDKTTGDFVSPPDAKITYNTRSVTPNADITAVTEDAKSRIEGVINETIGLANKDVISRDTNPDNKAIDDKESELGNMITDAQRYMANKAGADVDFAMTNNGGIRSDLTTRLANGQNEITWGAAQAVQPFGNILQVVEMTGADILEALNQQYLSNQTYFLQISGLKYTFTDTDDLDHAYKVASVTTEDGTPLKTDQKYKVVINDFLFGGGDGFSAFKKANLVTAIDPDTETFINYIKDQKAAGKVITAQKEGRKVYKSQAEIDKETKDAAIKAIKEATKINKLAEKDKTLTGTTLPGATVSVQKATANARMALAAGPNATADANGKFSVDVTSLNLKKGDQITTTITDPNGYSTTFQATVQAAATTPPDNGNGGTDNGNGNGNNGGTDGNGGTNNGNGSGTNGGTTTTEDPTTTTSNTSTTGTSSNTSLPTTGDTAGLATVFGVILTTTALYVLRKRS
Atome Classification :
(20 SA)
------------------.........10........20........30....----.----...40........50........60-.------.--.-----......70...--.....80........90........100.......110--.--------..-....120.......130......---.140.......150.......160.......170.......180-........190.....-----....----200.......210..-.....220-.....---..230.......240-.......250.--.------------------------..---...260.....-..270......--.280.......290.......300-----------..--..-------------------.--------------...------.310.......320---..------....-...330----------------------....--...-.-.340....---------.---------.-.350--------........360---........370......-.380.......390.......400.......-----410.......420.......430.......440.......450......-.460.......470...---.---------...480-------.-----........-490.......500-----.-----........510..----.-..----..520.......530.......540-.--...--...-550.......560.------......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------V
K
V
N
K
F
F
KKT
T
H
V
L
L
V
AG
L
T
I
GLTAPFTGTTAQAA----A----
D
T
V
P
I
Q
I
L
G
INDF
H
G
A
L
E
TASKDA--S------G--S-----PIG
G
A
D
Y
L
A
TN--LD
N
A
T
N
S
F
LQANPGATTD
N
A
I
R
V
QAGDMVGA
S
P
A
V
S
G
L--L--------QD-E
P
T
M
K
V
L
Q
KMNFEVGTLGN
H
E
F
D
---EG
L
P
E
Y
K
R
I
L
DGVSTNKFG
P
I
V
E
A
Y
P
R
VKSD
M
K
I
V
A
A
N
VVNKG--T
N
T
V
A
E
G
F
L
--
P
Y
Y
V
K
-----EID
G
----
V
K
V
G
F
I
G
I
V
TTEIP
N
-
L
V
L
A
N
HIK-
D
Y
D
F
L
---
D
E
A
E
T
I
V
K
Y
S
A
E
LRG-QG
V
N
A
I
V
V
L
SH--V------------------------PA---LSTGNPNTGT
K
-
Q
D
V
A
G
E
A
A
N
M
M
--
T
KANELDPNN
S
V
D
L
V
L
AGHNHQ-------------YT--NG-------------------L--------------VG
K
------
T
R
I
V
Q
SYNNGKA-----F
S
------
D
VTG-ELDK------------------------TTGD--FVS-P-PD
A
K
I
T
Y
N---------T---------R-SVT---------PNA
D
I
T
A
V
T
E
----
D
A
K
S
R
I
E
G
V
I
N
E
TIGLA-NKDVISRDTNPDNKAID
D
K
E
S
E
L
G
N
M
I
T
D
A
Q
-----
R
Y
M
ANKAGA
D
V
D
F
A
MTNNGG
I
R
S
D
L
T
T
R
LANGQN
E
I
T
W
G
A
A
Q
A
V
Q
P
F
G
N
-
I
L
Q
V
V
EMT
G
A
D
I
L
E
A
L
N
---
Q
---------
Q
Y
LS---------N-----
Q
T
Y
F
L
Q
IS-G
L
K
Y
T
FTDTDD-------L-----DH
A
Y
K
V
A
S
V
TTED----G-TP----LKTD
Q
K
Y
K
V
V
I
N
D
FLFGGGD
G
F
S
A
F
-K--KA
N
--
L
V
T
-
A
IDP
D
T
E
T
F
I
N
Y
I
K
------DQKAAG
K
V
I
T
AQKE
G
R
K
V
Y
K
S
Q
A
EID
K
E
T
K
D
A
A
I
K
A
I
K
E
A
T
K
I
N
K
L
A
EKDKTLTGTTLPG
A
T
V
S
V
Q
KATAN
A
R
M
A
L
AAGPNATADAN
G
K
F
S
V
D
V
T
S
L
NLKKG
D
Q
I
T
T
T
ITDPNGYST
T
F
Q
A
T
V
Q
AAATTPPDNGNGGTDNGNGNGNNGGTDGNGGTNNGNGSGTNGGTTTTEDPTTTTSNTSTTGTSSNTSLPTTGDT
A
G
L
A
T
V
F
G
V
I
L
T
T
T
A
L
Y
V
LRKRS
42
HHSearch
96.50
28%
-52
- C1 -
2Z1A
4
?
A:
[28-534]
----------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
L
--
S
G
E
----
K
--
T
-----
P
V
G
G
V
A
R
R
V
A
L
--
F
D
R
V
W
A
----
R
A
-----
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
-
F
N
Q
--
Y
--------
R
G
-
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
---
L
G
P
G
P
L
A
D
F
L
K
G
-----------------
A
R
F
K
V
V
S
A
N
V
D
A
S
R
--
E
P
R
L
K
G
L
F
A
--
P
Y
A
V
V
-----
V
V
G
G
----
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
-
I
S
N
P
G
--
P
-
T
V
A
F
L
---
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
--
L
------------------------
G
Y
---
G
E
D
----------------
L
K
L
A
--
R
R
------
L
V
G
V
Q
V
I
V
G
G
H
S
H
T
-------------
L
L
--
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
--------------
G
K
D
------
V
L
V
V
Q
A
W
E
W
G
K
V
-----
V
G
------
L
L
E
V
-
T
F
D
A
------------------------
K
G
E
----
L
L
-
A
-
Y
K
G
E
A
L
L
M
---------
T
---------
P
E
A
A
P
---------
E
D
F
F
A
K
E
A
L
L
----
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
--
D
L
V
G
E
R
----
A
V
V
R
R
R
E
S
N
L
G
N
L
I
T
D
G
M
-----
L
W
K
T
R
N
--
A
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
------
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
---
N
---------
G
V
S
Q
WEN------
T
-----
A
G
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
---------------
A
G
S
R
V
V
R
V
E
V
K
T
EKG
Y
-
V
P
----
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
-
K
--
E
A
Q
GY
R
V
D
-
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
------
E
L
----
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.09
28%
-52
- C1 -
2Z1A
4
?
A:
[28-527]
----------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
L
--
S
------
G
E
K
T
-----
P
V
G
G
V
A
R
R
V
A
L
--
F
D
R
V
W
---------
A
R
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
RG
L
--------
A
D
-
R
Y
F
M
---
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
---
L
G
P
G
P
L
A
D
F
L
K
G
-----------------
A
R
F
K
V
V
S
A
N
V
D
A
S
R
--
E
P
R
L
K
G
L
F
A
--
P
Y
A
V
V
-----
V
V
G
G
----
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
-
I
--
S
N
P
G
P
-
T
V
A
F
L
---
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
--
L
------------------------
G
Y
G
E
D
L
K
L
A
R
R
L
V
G
V
Q
-
V
I
V
G
G
H
S
H
T
L
L
G
S
F
P
H
K
E
L
S
P
A
G
P
Y
P
T
V
V
--
K
N
P
E
-------------
G
K
--
D
V
-------------------
L
--------------
V
-----------
V
Q
A
W
E
W
G
K
V
-----
V
G
L
L
E
V
T
F
D
A
K
G
-
E
L
L
A
------------------------
Y
K
G
E
A
L
L
M
T
-
P
-
E
A
A
P
E
D
F
F
---------
A
---------
K
-
E
A
--------------
L
L
A
Y
A
Q
----
P
V
M
A
L
M
Q
Q
V
I
A
E
----
A
-
K
V
D
L
V
G
-----
E
R
A
V
V
R
R
R
E
S
N
L
G
N
L
I
T
D
G
M
-----
L
W
K
T
R
N
A
G
T
Q
I
--
A
L
Q
N
G
G
G
I
R
A
S
I
P
------
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
---------
Q
W
E
N
---------
T
-----
A
G
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
-------
A
-----
G
S
R
V
V
R
V
E
V
K
T
E
K
----
G
Y
V
P
----
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
-
K
--
E
A
Q
GY
R
V
D
-
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
------
E
L
----
K
V
V
E
A
G
L
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.80
25%
-53
- C1 -
4H1S
4
5NTD_HUMAN
A:
[4-520]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VNASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NG
V
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
PL
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
KVRGVD
V
V
V
G
G
HSN
T
F
---
L
Y
T
G
N
P
--
P
S
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
N
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
N
Y
--
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
T
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
-
N
N
G
T
--
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
----
D
-------
L
SRKPG
D
R
V
V
K
L
D
V
L
C
T
K
C
----
R
-
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.94
24%
-52
- C1 -
4H2I
5
5NTD_HUMAN
A:
[4-520]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VDASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NG
V
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
PL
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
K
VRGVDVVVGGHSN
T
F
---
L
Y
T
G
N
P
P
S
--
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
D
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
---
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
----
D
-------
L
SRKPG
D
R
V
V
K
L
D
V
L
C
T
K
C
----
R
-
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.80
24%
-53
- C1 -
4H1Y
6
5NTD_HUMAN
P:
[23-542]
---------------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VDASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NGV
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
S
A
S
G
PL
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
GFEMDKLIAQKVRGVDVVVGGHSN
T
F
---
L
Y
T
G
N
P
P
S
--
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
D
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
INNNL
R
H
A
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
---
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
SVH------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
PGDRVVK
L
-----
D
V
L
C
T
S
C
R
V
P
S
Y
D
-------
P
----
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.74
24%
-52
- C1 -
4H2B
5
5NTD_HUMAN
A:
[27-543]
------------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VDASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NG
V
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
S
A
S
G
P
L
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
K
VRGVD
V
V
V
G
GHSN
T
F
---
L
Y
T
G
N
P
P
S
--
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
D
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
---
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
PGDRVV
K
L
-----
D
V
L
C
T
S
C
R
V
P
S
Y
D
-------
P
----
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.64
24%
-54
- C1 -
4H2G
5
5NTD_HUMAN
A:
[23-542]
---------------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VDASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NG
V
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
KVRGVDVVVGGHSN
T
F
---
L
Y
T
G
N
P
P
S
--
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
D
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
---
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
PGDRVV
K
L
-----
D
V
L
C
T
A
C
A
V
P
S
Y
D
-------
P
----
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.59
24%
-50
- C1 -
4H2F
4
5NTD_HUMAN
A:
[23-542]
---------------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
--
S
------
K
--
C
VDASR
C
M
G
G
V
A
R
L
F
T
K
--
V
Q
Q
I
R
----
R
A
E
P
-----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
--
Y
--------
K
G
-
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
NG
V
E
G
L
I
E
--------------
P
L
L
K
-----
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
PL
A
S
Q
I
S
G
L
Y
L
--
P
Y
K
V
L
-----
P
V
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
---
F
L
S
N
P
G
T
-
N
L
V
F
E
---
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
--
S
G
F
E
M
D
K
L
I
A
Q
KVRGVDVVVGGHSN
T
F
---
L
Y
T
G
N
P
P
S
--
K
-
E
V
P
A
G
K
Y
P
F
I
V
--
T
S
D
D
G
-----------------------------------------------------------------------
R
K
------
V
P
V
V
Q
A
Y
A
F
G
K
Y
-----
L
G
------
Y
L
K
I
-
E
F
D
E
------------------------
R
-
G
N
--
V
I
S
-
S
-
H
G
N
P
I
L
L
D
---------
S
-----------
S
I
P
---------
E
D
P
S
I
K
A
D
I
N
----
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
----
K
T
I
V
Y
L
D
G
S
--
S
Q
S
C
R
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
E
M
F
W
N
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
---
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
---
H
S
V
H------
R
Y
G
Q
---------
S
-----
T
G
E
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
PGDRVV
K
L
-----
D
V
L
C
T
A
C
A
V
P
S
Y
D
-------
P
----
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
-
K
--
D
E
L
--
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
------
K
M
----
K
V
I
Y
P
A
V
E
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
83.60
24%
-42
* C1 *
3IVE
5
?
A:
[4-500]
---------------------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
IA
D
G-----
K
--
R
-----
D
I
G
G
W
A
N
I
T
T
L
--
V
K
Q
E
K
A
----
K
N
-----
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
-
S
S
L
--
T
--------
K
G
-
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
---
H
G
W
D
N
T
L
L
Q
L
S
Q
-----------------
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
--
S
S
K
-
S
F
W
D
K
--
P
Y
T
I
I
-----
E
K
D
G
----
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
-
G
I
E
A
R
---
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
H
--
E
------------------------
G
V
---
P
A
R
Q
S
S
M
---
D
V
R
R
A
L
D
K
D
I
Q
T
A
--------
S
Q
V
K
G
L
D
I
L
I
T
G
H
A
H
V
-------------
G
T
--
P
E
-------------------
P
I
K
------------
V
G
N
------
T
L
I
L
S
T
D
S
G
G
I
D
-----
V
G
------
K
L
V
L
-
D
Y
K
E
------------------------
K
P
H
N
--
F
T
V
---
K
N
F
E
L
K
T
I
---------
Y
A--------
D
-
E
W
K
---------
P
D
Q
Q
T
K
Q
V
I
D
----
G
W
N
K
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
--
E
L
K
R
--------
A
Y
G
E
S
A
S
L
G
N
L
A
A
D
A
L
-----
L
A
A
A
G
---
K
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
------
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
---
H
---------
G
A
S
L
---------------
S
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
---------------
V
G
Q
R
V
I
T
L
T
L
N
----
G
-
K
P
----
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
-
T
--
E
G
K
A
R
N
I
T
-
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
------
A
G
----
N
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
79.52
20%
-34
- C1 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
---------------------------------------------------------
H
----
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
L
E
P
H
E
T
R
I
--
N
LNG
Q
Q
T
K
--
V
-----
D
I
G
G
F
S
A
V
N
A
K
--
L
N
K
L
R
K
K
---------
Y
K
N
P
L
V
L
H
A
G
D
A
I
T
G
T
L
Y
F
T
-
L
--
F
--------
G
G
-
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
D
---
A
G
N
E
G
L
L
K
L
L
E
P
L
-----------------
K
I
P
V
L
S
A
N
V
I
P
D
K
--
S
S
I
L
Y
N
K
W
K
--
P
Y
D
I
F
-----
T
V
D
G
----
E
K
I
A
I
I
G
L
D
T
V
N
K
T
V
-
N
S
-
S
S
P
G
K
-
D
V
K
F
Y
---
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
Q
-
Q
G
I
N
K
I
I
L
L
S
H
--
A
G
S
E
---------------------
K
N
---
I
E
I
A
Q
K
V
N
D
I
D
-
V
I
V
T
G
D
S
H
Y
L
Y
--
G
N
D
E
L
R
S
L
K
L
P
---
V
I
Y
E
Y
P
L
E
-------------
F
K
--
N
P
-------------------
N
--------------
G
E
P
------
V
F
V
M
E
G
W
A
Y
S
A
V
-----
V
G
------
D
L
G
V
-
K
F
S
P
EG
I
A
S
I
TRKIP
H
V
L
M
S
SH
K
L
Q
V
K
N
S
E
G
K
--
W
A
E
-
L
-
T
G
D
E
R
K
K
A
---------
L
---------
D
-
T
L
K
S
MKSISLD
D
H
D
A
K
T
D
K
L
I
A
----
K
Y
K
S
E
K
D
R
L
A
Q
E
I
V
G
V
I
-
T
G
S
A
M
P
-
G
G
S
A
N
R
I
P
N
K
A
G
S
N
P
E
G
S
I
A
T
R
F
I
-----
A
E
T
M
Y
N
E
L
K
T
V
D
L
T
I
Q
N
A
G
G
V
R
A
D
I
L
------
P
G
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
-
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
---
D
---------
A
M
Q
F
---------
A
L
VDGS
T
G
A
F
P
Y
G
A
-
G
I
R
Y
E
A
N
E
T
P
N
-------
A
-----
E
G
K
-
R
L
V
S
V
E
V
L
N
KTQ
Q
W
-
E
P
----
I
D
D
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
D
G
Y
K
T
F
-
G
--
K
L
F
---------------------------------------------------------------------------------------------------------------------------
N
D
P
K
Y
E
G
V
D
T
Y
L
P
----
D
A
E
S
F
I
K
F
M
K
K
H
P
H
F
E
A
Y
T
S
S
N
------------------------------------------------------------------------------
V
K
F
N
A
S
T
13
PsiBlast_PDB
79.01
21%
-53
- C1 -
2USH
7
USHA_ECOLI
A:
[26-531]
----------------------------------------------------------YEQD
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
G
E
--
Y
------
G
---------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
-
S
D
L
--
Q
--------
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
------
Q
E
K
W
-----------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
L
--
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
------
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
S
N
A
P
-
G
D
V
--
E
M
A
R
A
L
---------
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
PVCMAAENKKQV
D
Y
V
--
P
G
-------------------
T
--------------
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
------
F
R
N
G
-
E
M
K
M
------------------------
V
N
Y
Q
--
L
I
P
-
V
N
L
K
K
K
V
---S
E
R
V
L
Y---
T
---------
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
-
E
G
D
---
R
D
K
------
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
--------
M
D
R
T
G
A
D
--
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
------
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
---------
Q
M
K
P
---------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
-------------------
K
I
K
------------
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
--
K
P
G
--
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
78.56
20%
-56
- C1 -
1HP1
7
USHA_ECOLI
A:
[3-500]
----------------------------------------------------
Q
----
D
----
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
---------------
Y
-----
G
E
Y
G
L
A
A
Q
K
T
L
--
V
D
G
I
R
K
E
V
A
A
E
G
-----
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
-
S
D
L
--
Q
--------
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
Q
E
K
W
-----------------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
--
L
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
-
D
I
E
F
R
---
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
------
S
N
A
P
G
D
V
E
M
A
--
R
A
L
----
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
-------------
P
V
--
C
M
AAENKKQVDYVPG
T
P
C
K
P
D
Q
--------------
Q
N
G
------
I
W
I
V
Q
A
H
E
W
G
K
Y
-----
V
G
------
R
A
D
F
-
E
F
R
N
------------------------
G
E
M
K
---
M
----
V
N
Y
Q
L
I
P
V
---------
N
LKKKRVLYT
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
----
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
--
R
L
E
G
D
----
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
-----
M
D
R
-----
T
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
------
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
---
A
---------
V
A
Q
M
KP-------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
--------------------
D
G
K
L
N
D
L
K
I
K
----
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
-
D
--
N
K
P
G-
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
------
K
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.69
21%
-50
- C1 -
1USH
7
USHA_ECOLI
A:
[26-531]
----------------------------------------------------------YEQD
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
G
E
--
Y
------
G
---------------
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
-
S
D
L
--
Q
--------
D
A
-
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
------
Q
E
K
W
-----------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
L
--
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
S
N
A
P
-
G
D
V
--
E
M
A
R
A
L
---------
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
--------------
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
------
F
R
N
G
-
E
M
K
M
------------------------
V
N
Y
Q
--
L
I
P
-
V
N
L
K
K
-----RVLY-----
T
---------
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
-
E
G
D
---
R
D
K
------
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
--------
M
D
R
T
G
A
D
--
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
------
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
---------
Q
M
K
P
---------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
L
-------
N
-----
D
L
K
I
K
------------
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
--
K
P
G
--
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.28
26%
-39
- C1 -
3IVD
4
?
A:
[59-501]
---------------------------------------------------------------------------------------------------------------------------------------------
A
G
D
Y
F
-
T
G
P
Y
I
S
S
L
--
T
--------
K
G
-
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
---
H
G
---
W
D
N
T
L
L
Q
L
S
Q
A
K
F
-
P
I
V
Q
G
-------------
N
I
F
Y
Q
N
--
S
---
S
K
S
F
W
DK
P
Y
T
I
I
-----
E
K
D
G
----
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
-
D
T
V
S
A
A
T
R
V
G
I
E
A
R
---
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
G
-
K
-
V
D
L
T
V
A
L
I
H
EG
V
------------------------
P
A
---
R
Q
S
S
M
G
G
T
-----
D
V
R
R
A
L
D
K
D
I
--
Q
T
A
S
Q
V
---
K
G
L
D
I
L
I
T
G
H
A
H
------------------------------------------------------
V
G
T
------
P
E
P
I
K
V
G
N
T
L
I
L
-----
S
T
------
D
S
G
G
I
D
V
G
K
------------------------
L
V
L
D
--
Y
K
E
-
K
-
P
H
N
F
T
V
K
N
---------
F
---------
E
-
L
K
T
---------
I
Y
A
D
E
W
K
P
D
Q
----
Q
T
K
Q
V
I
D
G
-
W
N
K
K
L
D
E
V
-
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
A
Y
G
E
S
A
S
-
L
G
N
L
A
A
D
A
--------
L
L
A
A
A
G
K
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
A
------
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
-
L
R
S
L
M
---
E
---------
H
G
A
S
---------
L
-----
S
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
-------
V
-----
G
Q
--
R
V
I
T
L
T
L
-
N
----
G
-
K
P
----
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
-
T
EG
K
A
R
--
N
I
T
-
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
GNTIT
D
E
Q
L
N
G
M
R
V
K
D
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
71.74
18%
-44
- C1 -
2WDC
18
?
A:
[77-554]
----------------------------------------------------
E
----
R
----
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
----------------
G
-----
P
I
G
G
M
G
A
L
T
A
L
--
I
R
D
Q
K
A
R
V
E
A
E
G
-----
G
K
A
L
V
L
D
G
G
D
T
W
T
N
S
G
L
-
S
L
L
--
T
--------
R
G
-
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
---
L
G
R
E
R
V
E
E
L
L
G
L
-----------------
F
R
G
E
F
L
S
Y
N
I
V
D
D
L
--
F
G
D
P
--
L
F
P
--
A
Y
R
I
H
-----
R
V
G
P
----
Y
A
L
A
V
V
G
A
S
Y
P
Y
V
K
V
-
S
H
P
E
S
F
T
E
-
G
L
S
F
A
---
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
--
N
------------------------
G
M
---
Q
L
D
----------------
A
A
L
A
--
E
------
R
I
R
G
I
D
L
I
L
S
G
H
T
H
D
-------------
L
T
--
P
R
P
W
-----------------
R
--------------
V
G
K
------
T
W
I
V
A
G
S
A
A
G
K
A
-----
L
M
------
R
V
D
L
-
K
L
W
K
------------------------
G
G
-----
I
A
-
N
-
L
R
V
R
V
L
P
V
---------
L
A--------
E
-
H
L
P
---------
K
A
E
D
V
E
A
F
L
K
----
A
Q
L
A
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
--
L
L
Y
K
--------
R
D
T
L
Y
S
T
W
D
Q
L
V
G
E
A
V
-----
K
A
I
Y
------
P
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
L
---
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
---
D
---------
I
A
S
N
V
F
TSDPFYQ
Q
-----
G
G
D
V
S
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
P
---------------
T
G
E
R
V
R
E
V
E
V
G
----
G
-
R
P
----
L
D
P
N
R
R
Y
L
A
A
A
Y
G
G
R
L
Q
------
R
V
-
G
--
E
A
K
--
P
G
Y
-
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
------
S
V
----
G
R
V
R
V
R
P
E
P
N
V
K
V
I
G
R
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
71.06
17%
-34
- C1 -
2WDC
18
?
A:
[21-562]
YDLPPYGDATLLYFSDLH
G
Q
A
F
P
H
Y
F
M
E
P
P
N
L
I
A
P
K
P
L
M
G
R
P
G
Y
L
T
G
E
A
I
L
R
Y
Y
GVE
R
----
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
G
P
---------------------
I
G
G
M
G
A
L
T
A
L
--
I
R
D
Q
K
A
R
V
E
A
E
G
G
-----
K
A
L
V
L
D
G
G
D
T
W
T
N
S
-
G
L
S
L
L
--
T
--------
R
G
-
E
A
V
V
R
W
Q
N
L
V
G
V
D
-
H
M
V
S
H
W
E
W
T
---
L
G
R
E
R
V
E
E
L
L
G
L
F
-----------------
R
G
E
F
L
S
Y
N
I
V
D
D
L
--
F
G
D
--
P
L
F
P
--
A
Y
R
I
H
-----
R
V
G
P
----
Y
A
L
A
V
V
G
A
S
Y
P
Y
V
K
V
-
S
H
P
E
S
F
T
E
-
G
L
S
F
A
---
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
---------------------------------------------------
N
G
M
Q
--
L
D
A
A
L
A
E
R
I
R
G
I
D
L
I
L
S
G
H
T
H
D
-------------
L
T
P
R
P
W
-------------------
R
--------------
V
G
K
------
T
W
I
V
A
G
S
A
A
G
K
A
-----
L
M
------
R
V
D
L
-
K
L
W
K
--------------------------
G
G
--
I
A
N
-
L
-
R
V
R
V
L
P
V
L
---------
A
---------
E
-
H
L
P
---------
K
A
E
D
V
E
A
F
L
K
----
A
Q
L
A
P
H
Q
D
H
L
F
T
P
L
A
V
S
-
E
T
L
L
Y
K
R
D
T
L
---------
Y
S
T
W
D
Q
L
V
G
E
A
V
-----
K
A
I
----
Y
P
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
L
P
G
-----
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
---
D
I
A
S
N
V
F
TSD
P
F
Y
Q
---------
Q
-----
G
G
D
V
S
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
P
-------
T
-----
G
E
R
V
R
E
V
E
V
---
G
----
G
-
R
P
----
L
D
P
N
R
R
Y
L
A
A
A
Y
-----
G
G
R
L
Q
R
V
G
-
E
--
A
K
P
--------------------------------------------------------------------------------------------------------------
G
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
R
P
E
P
--------
N
V
K
V
I
G
R
N
Y
R
L
P
E
V
T
G
--------------------------------------------------------------------------------------
47
HHSearch
69.78
24%
-50
- C1 -
3JYF
12
?
A:
[4-338]
---------------------------------------------------------
A
----
A
T
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
K
--
D
------
A
A-
T
-----
E
K
F
G
L
V
R
T
A
S
L
--
I
E
Q
A
R
A
----
E
V
-----
K
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
-
D
Y
--
M
A
A
K
GLKEG
D
V
-
H
P
V
Y
K
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
N
---
Y
G
L
D
F
L
H
K
A
L
A
G
-----------------
A
K
F
P
Y
V
N
A
N
I
I
D
A
K
--
T
G
K
P
--
M
F
T
--
P
Y
L
I
Q
D
T
R
V
V
D
S
D
G
Q
I
H
T
L
R
I
G
Y
I
G
F
V
P
P
Q
I
M
T
-
W
D
K
A
N
L
N
G
-
K
V
T
V
N
---
D
I
T
E
T
A
R
K
Y
I
P
E
M
R
A
-
K
G
A
D
V
V
V
V
V
A
H
--
S
------------------------
G
L
---
S
A
D
P
Y
Q
A
-------
M
A
E
N
S
V
Y
Y
L
--------
S
Q
V
P
G
V
D
A
I
M
F
G
H
A
H
A
-------------
V
F
--
P
G
-------------------
K
DFANIKGADIAKGT
L
N
G
------
V
P
A
V
M
P
G
M
W
G
D
H
-----
L
G
------
V
V
D
L
-
V
L
N
N
------------------------
D
S
G
K
--
W
Q
V
T
Q
-
S
K
A
E
A
R
P
I
---------
Y
DAVAKK---
S
-
L
A
A
---------
E
D
G
K
L
V
S
V
L
K
----
A
D
H
D
A
T
R
E
F
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.57
21%
-55
- C1 -
1HPU
3
USHA_ECOLI
A:
[69-506]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
------
Q
E
K
W
-----------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
L
--
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
S
N
A
P
-
G
D
V
--
E
M
A
R
A
L
---------
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
--------------
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
------
F
R
N
G
-
E
M
K
M
------------------------
V
N
Y
Q
--
L
I
P
-
V
N
L
K
K
K
V
T
W
E
DG
K
S
E
R
V
L
Y
T
---------
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
PFQN
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
-
E
G
D
---
R
D
K
------
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
--------
M
D
R
T
G
A
D
--
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
------
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
---------
Q
M
K
P
---------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
L
-------
N
-----
D
L
K
I
K
------------
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
--
K
P
G
--
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.01
21%
-58
- C1 -
1OI8
4
USHA_ECOLI
A:
[69-506]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
------
Q
E
K
W
-----------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
L
--
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
S
N
A
P
-
G
D
V
--
E
M
A
R
A
L
---------
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
--------------
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
------
F
R
N
G
-
E
M
K
M
------------------------
V
N
Y
Q
--
L
I
P
-
V
N
L
K
K
K
V
T
W
E
DG
K
S
E
R
V
L
Y
T
---------
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
-
E
G
D
---
R
D
K
------
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
--------
M
D
R
T
G
A
D
--
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
------
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
---------
Q
M
K
P
---------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
L
-------
N
-----
D
L
K
I
K
------------
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
--
K
P
G
--
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.01
21%
-58
- C1 -
1OID
1
USHA_ECOLI
A:
[69-506]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
---
N
P
L
T
V
L
R
Q
------
Q
E
K
W
-----------
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
--
T
G
E
R
L
--
F
K
--
P
W
A
L
F
-----
K
R
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
-
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
---
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
--
M
------------------------
G
H
---
Y
D
N
G
E
H
G
C
N
A
P
-
G
D
V
--
E
M
A
R
A
L
---------
P
A
G
S
L
A
M
I
V
G
G
H
S
Q
D
PVCMAAENKKQVD
Y
V
--
P
G
-------------------
T
--------------
P
C
K
P
D
Q
Q
NG
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
------
F
R
N
G
-
E
M
K
M
------------------------
V
N
Y
Q
--
L
I
P
-
V
N
L
K
K
K
V
T
W
E
DG
K
S
E
R
V
L
Y
T
---------
P
-
E
I
A
---------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
-
E
G
D
---
R
D
K
------
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
--------
M
D
R
T
G
A
D
--
F
A
V
M
S
G
G
G
I
R
D
S
I
E
A
------
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
-
A
---------
Q
M
K
P
---------
D
-----
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
D
G
K
L
-------
N
-----
D
L
K
I
K
------------
G
-
E
P
----
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
--
K
C
G
--
Y
V
N
-
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------