@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0224: (2016-03-13 )
LKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEEAVARALQMAEDGAAIIDVGGISTRPGFSEVTPDEELARIIPVIKAVRTKLPDIWISVDSWRAEVAEQAILAGADMINDQWGAKKEPKIAEVAAKYDVPICLMHNRENAQYDNFLEDVKKDLLESIAIAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPGDRMEGTGATTVYGFSKGCTITRVHDVLPIARMVRMTDAITGKLDITNL
Atome Classification :
(61 SA)
.........10..-......20........30-........40...-----.....50........60........70........80-....----.....90........100.......110.......120.......-130.....--..---140------.--------.--------.-------.----------------------------..------..150----.......-----160.......170.......---180..-.-....190......-----.----------------200.......210......---------.220------..------......230......--.240.......------250.......260.......270
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
LKK
W
K
R
D
H
L
G
M
V
M
-
G
I
LNVTPDSFSDGG
K
Y
M
Q
-
V
E
E
A
V
A
R
A
L
Q
MAE-----DG
A
A
I
I
D
VGGISTRPGFSEVT
P
D
E
E
L
A
R
I
I
P
V
I
K
A
V
--
R
TKL----P
D
I
W
I
S
V
D
S
W
R
A
E
V
A
E
Q
A
I
L
AGADMINDQWGAKKEP
K
I
A
E
V
A
A
KY-DV
P
I
C
L
M
H--NR---EN-------A--------
Q
--------
Y
-------
D
----------------------------
N
F
------
L
E
D
V
K
----
K
D
L
L
E
S
I
-----
A
I
A
KAASVPD
E
H
I
I
LDPGFG---FVKT
P
-
A
-
Q
N
L
E
V
L
R
R
I
D
E
I
V
-----
A
----------------
L
G
Y
E
V
LLGTSRK
S
T
I
G
L
V
L
---------GT-T------PG------DRMEGTGA
T
T
V
Y
GFS--KG
C
T
I
T
R
V
H
D
V
------
L
P
I
A
R
M
V
R
M
T
D
AITGKLDITNL
19
PsiBlast_PDB
92.75
59%
-105
- C8 -
3TYD
8
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
26
PsiBlast_CBE
91.52
59%
-106
- C8 -
4NHV
8
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
42
PsiBlast_CBE
91.44
59%
-105
- C8 -
3H2E
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
----
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
36
PsiBlast_CBE
91.11
59%
-108
- C8 -
3TYD
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
37
PsiBlast_CBE
90.49
59%
-103
- C8 -
3TYC
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
12
PsiBlast_PDB
90.34
59%
-97
- C8 -
3H2E
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
46
PsiBlast_CBE
90.16
59%
-104
- C8 -
1TX2
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
25
PsiBlast_CBE
90.15
59%
-93
- C8 -
4NIL
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
17
PsiBlast_PDB
90.10
59%
-101
- C8 -
3TYA
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
6
PsiBlast_PDB
89.90
59%
-100
- C8 -
3H21
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
5
PsiBlast_PDB
89.84
59%
-101
- C8 -
1TX2
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
13
PsiBlast_PDB
89.82
59%
-100
- C8 -
3H2F
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
33
PsiBlast_CBE
89.81
59%
-103
- C8 -
4D8Z
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
11
PsiBlast_PDB
89.79
59%
-105
- C8 -
3H2A
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
51
PsiBlast_CBE
89.70
59%
-99
- C8 -
3V5O
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
N
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
2
PsiBlast_PDB
89.64
59%
-102
- C8 -
1TWW
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
21
PsiBlast_CBE
89.60
59%
-103
- C8 -
4NL1
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
--
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
18
PsiBlast_PDB
89.59
59%
-101
- C8 -
3TYB
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
27
PsiBlast_CBE
89.53
59%
-92
- C8 -
4NHV
8
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
39
PsiBlast_CBE
89.52
59%
-103
- C8 -
3TYA
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
20
PsiBlast_PDB
89.40
59%
-100
- C8 -
3TYE
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
35
PsiBlast_CBE
89.34
59%
-103
- C8 -
4D8A
5
?
A:
[41-293]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
-------
48
PsiBlast_CBE
89.32
59%
-102
- C8 -
1TWZ
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
30
PsiBlast_CBE
89.23
59%
-102
- C8 -
4DAI
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
34
PsiBlast_CBE
89.16
59%
-100
- C8 -
4D8Z
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
14
PsiBlast_PDB
89.16
59%
-98
- C8 -
3H2M
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
4
PsiBlast_PDB
89.11
59%
-100
- C8 -
1TX0
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
29
PsiBlast_CBE
89.10
59%
-104
- C8 -
4DAI
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
44
PsiBlast_CBE
89.00
59%
-104
- C8 -
3H2A
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
32
PsiBlast_CBE
88.94
59%
-100
- C8 -
4D9P
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
41
PsiBlast_CBE
88.88
59%
-103
- C8 -
3H2M
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
31
PsiBlast_CBE
88.77
59%
-104
- C8 -
4D9P
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
8
PsiBlast_PDB
88.72
59%
-94
- C8 -
3H23
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
15
PsiBlast_PDB
88.67
59%
-104
- C8 -
3H2N
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
47
PsiBlast_CBE
88.44
59%
-102
- C8 -
1TX0
6
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
28
PsiBlast_CBE
88.40
59%
-102
- C8 -
4DB7
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
45
PsiBlast_CBE
88.22
59%
-104
- C8 -
3H24
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
7
PsiBlast_PDB
88.19
59%
-103
- C8 -
3H22
5
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
38
PsiBlast_CBE
88.10
59%
-102
- C8 -
3TYB
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
40
PsiBlast_CBE
88.04
59%
-103
- C8 -
3H2N
5
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
43
PsiBlast_CBE
87.76
59%
-105
- C8 -
3H2C
7
?
B:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
-------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
9
PsiBlast_PDB
87.76
59%
-98
- C8 -
3H24
6
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
10
PsiBlast_PDB
87.25
59%
-98
- C8 -
3H26
4
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
58
PsiBlast_CBE
86.65
42%
-102
- C8 -
1AJ2
2
DHPS_ECOLI
A:
[17-271]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
--
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
-
I
R
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
--
M
Q
---
G
N
PKTMQ
E
A
P
--------
K
--------
Y
-------
D
----------------------------
D
V
------
F
A
E
V
N
----
R
Y
F
I
E
Q
I
-----
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
S
-
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---------
N
V
-
G
------
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
--
Q
G
A
H
I
I
R
V
H
D
V
------
K
E
T
V
E
A
M
R
V
V
E
A
----------
59
PsiBlast_CBE
85.23
42%
-97
- C8 -
1AJ0
3
DHPS_ECOLI
A:
[17-271]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
--
A
Q
R
F
-----
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
-
I
R
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
--
M
Q
---
G
N
PKTM
Q
E
A
P
--------
K
--------
Y
-------
D
----------------------------
D
V
------
F
A
E
V
N
----
R
Y
F
I
E
Q
I
-----
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
S
-
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---------
N
V
-
G
------
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
--
Q
G
A
H
I
I
R
V
H
D
V
------
K
E
T
V
E
A
M
R
V
V
E
A
----------
16
PsiBlast_PDB
84.64
59%
-100
- C8 -
3H2O
3
?
A:
[41-294]
----------
L
I
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
V
K
L
----
P
---
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
--
N
R
---
D
N
-------
M
--------
N
--------
Y
-------
R
----------------------------
N
L
------
M
A
D
M
I
----
A
D
L
Y
D
S
I
-----
K
I
A
K
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
T
P
-
E
-
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
---------
D
L
-
P
------
V
E
------
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
--
K
G
C
E
F
V
R
V
H
D
V
------
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
K
------
78
HHSearch
84.39
41%
-96
- C8 -
1AJ0
3
DHPS_ECOLI
A:
[9-278]
--
S
L
D
L
S
-
H
P
H
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
--
A
Q
R
-----
F
E
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
E
-
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
--
M
Q
---
G
N
-------
P
--------
K
TM
Q
E
A
P
K
-
Y
-------
D
----------------------------
D
V
------
F
A
E
V
N
----
R
Y
F
I
E
Q
I
-----
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
S
-
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
---------
N
V
-
G
------
P
S
------
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
--
Q
G
A
H
I
I
R
V
H
D
V
------
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
---
60
PsiBlast_CBE
81.16
42%
-92
- C8 -
3TZF
3
?
B:
[20-262]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
--
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
--
M
Q
G
QP
K
N
-------
M
--------
Q
HSPY----
Y
-------
D
----------------------------
D
L
------
M
T
D
I
N
----
R
F
F
Q
H
H
I
-----
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
A
-
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---------
N
V
-
P
------
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
--
Q
G
A
Q
I
I
R
V
H
D
V
----------------------------
75
HHSearch
81.10
41%
-101
- C8 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
--------
P
V
Q
V
M
-
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
--
A
A
------
Q
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--
W
R
---
A
V
-------
S
--------
A
DTPHVPVR
Y
-------
G
----------------------------
N
V
------
V
A
E
V
R
----
A
D
L
L
A
S
V
-----
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
A
-
Q
-
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---------
A
G
-
P
DGVMRP
T
D
------
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
--
H
G
A
W
G
V
R
V
H
D
V
------
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
-----
63
PsiBlast_CBE
80.97
42%
-95
- C8 -
3TYZ
4
?
A:
[20-262]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
--
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
--
M
Q
G
QP
K
N
-------
M
--------
Q
H
S
P
Y
----
Y
-------
D
----------------------------
D
L
------
M
T
D
I
N
----
R
F
F
Q
H
H
I
-----
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
A
-
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---------
N
V
-
P
------
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
--
Q
G
A
Q
I
I
R
V
H
D
V
----------------------------
66
PsiBlast_CBE
80.94
40%
-101
- C8 -
1EYE
2
DHPS1_MYCTU
A:
[8-272]
-----------
V
M
-
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
--
A
A
Q
------
G
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
--
W
R
---
A
V
-------
S
ADTPHVPV
R
--------
Y
-------
G
----------------------------
N
V
------
V
A
E
V
R
----
A
D
L
L
A
S
V
-----
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
T
A
-
Q
-
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
---------
A
G
-
P
------
D
G
VMRPTD
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
--
H
G
A
W
G
V
R
V
H
D
V
------
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
-------
73
HHSearch
80.60
37%
-99
- C8 -
2Y5S
13
?
A:
[16-290]
-
F
E
L
T
F
E
-
R
P
L
V
M
-
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
--
R
P
------
L
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
Q
-
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
--
M
L
---
G
E
-------
P
--------
Q
TM
Q
V
G
E
PD
Y
-------
G
----------------------------
D
V
------
V
T
D
V
R
----
D
F
L
A
A
R
A
-----
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
D
-
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---------
G
G
K
P
------
P
L
------
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
--
R
G
A
A
I
V
R
V
H
D
V
------
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
------
62
PsiBlast_CBE
80.05
42%
-95
- C8 -
3TYZ
4
?
B:
[20-262]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
--
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
--
M
Q
GQP
K
N
-------
M
--------
Q
HSPY----
Y
-------
D
----------------------------
D
L
------
M
T
D
I
N
----
R
F
F
Q
H
H
I
-----
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
A
-
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---------
N
V
-
P
------
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
--
Q
G
A
Q
I
I
R
V
H
D
V
----------------------------
61
PsiBlast_CBE
79.62
42%
-94
- C8 -
3TZF
2
?
A:
[20-262]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
--
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
--
M
Q
G
QP
K
N
-------
M
--------
Q
H
S
P
Y
----
Y
-------
D
----------------------------
D
L
------
M
T
D
I
N
----
R
F
F
Q
H
H
I
-----
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
A
-
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---------
N
V
-
P
------
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
--
Q
G
A
Q
I
I
R
V
H
D
V
----------------------------
79
HHSearch
78.92
36%
-86
- C8 -
3TR9
4
?
A:
[22-293]
--
R
I
V
F
S
-
E
P
A
V
M
-
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
--
L
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
A
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
--
K
K
R
-----
F
P
Q
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
I
N
D
Q
R
A
L
Q
L
-
D
D
A
L
T
T
V
S
A
L
-
K
T
P
V
C
L
M
H
--
F
P
---
S
E
-------
T
--------
R
KPGSTT--
H
-------
F
----------------------------
Y
F
------
L
Q
S
V
K
----
K
E
L
Q
E
S
I
-----
Q
R
C
K
K
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GN
Y
G
K
N
V
-
S
-
E
N
F
Y
L
L
N
K
L
P
E
F
V
-----
A
----------------
M
G
L
P
V
L
S
G
W
S
R
K
S
M
I
G
D
V
L
---------
N
Q
-
P
------
P
E
------
N
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
--
H
G
A
S
I
I
R
T
H
D
V
------
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
S
V
D
-----
65
PsiBlast_CBE
77.00
42%
-109
- C8 -
2DZB
1
?
B:
[31-272]
-----------
L
L
-
G
V
L
N
L
T
P
D
-----------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
--
L
S
L
------
G
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
D
E
-
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
P-----
A
H
-------
A
--------
R
--------
Y
-------
R
----------------------------
D
V
------
V
A
E
V
K
----
A
F
L
E
A
Q
A
-----
R
R
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
---
F
G
K
L
L
-
E
-
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
---------
G
V
-
E
D-----
P
A
------
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
--
K
G
V
R
L
L
R
V
H
D
V
----------------------------
68
PsiBlast_CBE
75.33
37%
-94
- C8 -
2Y5S
13
?
A:
[24-274]
----------
L
V
M
-
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
--
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
-
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
--
M
L
---
G
E
-------
P
--------
Q
TM
Q
V
G
E
PD
Y
-------
G
----------------------------
D
V
------
V
T
D
V
R
----
D
F
L
A
A
R
A
-----
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
-
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---------
G
G
-
K
------
P
P
L-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
--
R
G
A
A
I
V
R
V
H
D
V
----------------------------
74
HHSearch
74.87
35%
-89
- C8 -
2BMB
1
FOL1_YEAST
A:
[222-544]
------
V
S
P
T
Y
I
M
-
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
--
R
E
S
T
ELPQ
D
K
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
--
T
R
---
G
D
-------
I
--------
S
--------
T
MNRLAHY
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
------
I
R
N
V
G
----
Q
E
I
G
E
R
Y
-----
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
---
F
A
K
T
W
-
K
-
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
---------
K
D
-
V
D-----
A
K
------
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
--
F
G
S
D
M
V
R
V
H
D
V
------
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
L
-----
67
PsiBlast_CBE
74.47
37%
-92
- C8 -
2Y5S
9
?
B:
[24-274]
----------
L
V
M
-
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
--
R
P
L
------
N
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
-
F
R
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
--
M
L
---
G
E
-------
P
--------
Q
TM
Q
V
G
E
PD
Y
-------
G
----------------------------
D
V
------
V
T
D
V
R
----
D
F
L
A
A
R
A
-----
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
-
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
---------
G
G
-
K
------
P
P
L-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
--
R
G
A
A
I
V
R
V
H
D
V
----------------------------
64
PsiBlast_CBE
74.26
42%
-92
- C8 -
3TYU
1
?
A:
[20-262]
-----------
V
M
-
G
I
L
N
V
T
P
D
S
------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
--
A
Q
R
F
-----
D
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
-
I
R
S
L
Q
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
--
M
Q
G-----------
M
--------
Q
HSPY----
Y
-------
D
----------------------------
D
L
------
M
T
D
I
N
----
R
F
F
Q
H
H
I
-----
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
N
L
-
A
-
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
---------
N
V
-
P
------
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
--
Q
G
A
Q
I
I
R
V
H
D
V
----------------------------
69
PsiBlast_CBE
72.49
35%
-101
- C8 -
2VEG
2
DHPS_STRR6
A:
[7-303]
-------
H
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
--
R
-
K
E
----
S
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
--
N
P
---
V
M
-------
A
--------
R
P
QHPSSLI
F
-------
P
----------------------------
H
F
GFAFTE
L
A
D
F
E
T
LP
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
---
F
G
L
T
K
-
K
-
E
N
L
L
L
L
R
D
L
D
K
L
H
-----
Q
----------------
K
G
Y
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
GFEVNP
E
T
-
E
------
L
G
------
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
-----------