@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1834: (2016-03-29 )
VLQTEMKVIQQTEIADKVYELILTGECVAGMSPGQFLMLKPSRSDLLMRRPISICSYDKTAKTCILLYRVEGDGTRDFSKLSEGDTIDVLGPLGKGFDIDTTPAPKTALLIGGGIGVPPMYQLGKELAEKGVQVMFVNGFQSAKDSFYAQEMAEYGTVHIATVDGSLGTQGFVTDITKNFPEEPDVIYSCGPKAMLQAVKASFPETKTYLSLEERMACGIGACYACVCPKADDTNKQFKVCEDGPVFRADEVKL
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------.........10...-----...--------------..20...---...---.---.30-.-.......40-...--.-----------------------------.-----------....50........60---.........70-.-----------------.--.--.-.-....-80....-...-..90......-------...100-------.......110.......120.......130-----.-----..--......140.......150----....------------..--.--160.--..----------.------.------.----...170.--..--..-----.-------.180---.-----...-..-...190......--..200-..-..-.---...210-------------------------------------------........220.......230.......-240.......250..---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------VL
Q
T
E
M
K
V
I
Q
Q
T
E
I
-----
A
D
K
--------------
V
Y
E
L
I
LT---G
E
C
---V---AGM-S-PG
Q
F
L
M
LK--PSR--S-----------------------------
D
-----------
L
L
M
RRPISICSYDKT----A
K
T
C
I
L
L
Y
R
V--E-----------------G--D--G-T-R
D
F
S
-K-LSEG-
D
T
I
-
D
V
L-GPLGKG-------FDIDTT-------PAP
K
T
A
L
L
I
GGGIGV
P
P
M
Y
Q
L
G
K
E
L
A
EK-------G-----
V
Q
--
V
M
F
VNGFQS
A
K
D
S
F
Y
A
Q
E
M
----
A
EYG------------
T
V
--
H
--
I
--
A
--TV----------D------G------S----LGTQ
G
F
V
--
T
D
--
I
T
-----K-------NF-----P-----EEP-
D
V
-
I
Y
SC
G
-
P
K
A
M
L
Q
--
A
V
K
-A-SF-PE-
T
---
K
T
Y
L
S
--------------------------------------------
L
E
E
R
M
A
C
G
I
G
A
C
Y
A
CVCPKADDTNK
Q
F
K
-VCEDGPVFRADEVKL---------
1
PsiBlast_PDB
95.99
45%
-110
- C3 -
1EP1
2
PYRK_LACLM
B:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
M
M
T
V
V
S
Q
R
E
V
-----
A
Y
N
--------------
I
F
E
M
V
L
K
---
G
T
L
---
V
---
D
E
M
-
D
L
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L
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L
A
--
V
P
N
--
G
-----------------------------
A
-----------
M
L
L
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I
S
S
W
D
K
R
----
A
K
T
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T
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D
E
-----------------
T
--
T
--
G
-
T
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Y
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L
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G
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A
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V
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D
V
M
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G
P
L
G
N
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-------
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P
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A
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V
-------
T
S
T
D
K
I
L
I
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G
G
G
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V
P
P
L
Y
E
L
A
K
Q
L
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K
T
-------
G
-----
C
Q
--
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
----
S
N
L
K
N
V
----------
T
L
--
K
--
I
--
A
--
T
D
----------
D
------
G
------
S
----
Y
G
T
K
G
H
V
--
G
M
--
L
M
-----
N
-------
E
I
-----
D
-----
F
E
V
-
D
A
-
L
Y
T
C
G
-
A
P
A
M
L
K
--
A
V
A
-
K
-
K
Y
-
D
Q
L
E
---
R
L
Y
I
S
--------------------------------------------
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
---------
29
HHSearch
95.62
46%
-106
- C3 -
1EP3
2
PYRK_LACLM
B:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
M
M
T
V
V
S
Q
R
E
V
-----
A
Y
N
--------------
I
F
E
M
V
L
K
---
G
T
L
---
V
D--
E
M
D
-
L
-
P
G
Q
F
L
H
L
A
--
V
P
N
--
G
-----------------------------
A
-----------
M
L
L
R
R
P
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S
I
S
S
W
D
K
R
----
A
K
T
C
T
I
L
Y
R
I
--
G
-----------------
D
ET
T
--
G
-
T
-
Y
K
L
S
-
K
-
L
E
S
G
-
A
K
V
-
D
V
M
-
G
P
L
G
N
G
-------
F
P
V
A
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V
-------
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
-------
G
-----
C
Q
--
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
----
S
N
L
K
N
V
----------
T
L
--
K
--
I
--
A
--
T
D
----------
D
------
G
------
S
----
Y
G
T
K
G
H
V
--
G
M
--
L
M
-----
N
-------
E
I
-----
D
-----
F
E
V
-
D
A
-
L
Y
T
C
G
-
A
P
A
M
L
K
--
A
V
A
-
K
-
K
Y
-
D
Q
-
L
E--
R
L
Y
I
S
--------------------------------------------
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
---------
2
PsiBlast_PDB
95.18
45%
-107
- C3 -
1EP2
2
PYRK_LACLM
B:
[3-261]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
M
M
T
V
V
S
Q
R
E
V
-----
A
Y
N
--------------
I
F
E
M
V
L
K
---
G
T
L
---
V
---
D
E
M
-
D
L
P
G
Q
F
L
H
L
A
--
V
P
N
--
G
-----------------------------
A
-----------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
----
A
K
T
C
T
I
L
Y
R
I
G
D
E
-----------------
T
--
T
--
G
-
T
-
Y
K
L
S
-
K
-
L
E
S
G
-
A
K
V
-
D
V
M
-
G
P
L
G
N
G
-------
F
P
V
A
E
V
-------
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
-------
G
-----
C
Q
--
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
----
S
N
L
K
N
V
----------
T
L
--
K
--
I
--
A
--
T
D
----------
D
------
G
------
S
----
Y
G
T
K
G
H
V
--
G
M
--
L
M
-----
N
-------
E
I
-----
D
-----
F
E
V
-
D
A
-
L
Y
T
C
G
-
A
P
A
M
L
K
--
A
V
A
-
K
-
K
Y
-
D
Q
L
E
---
R
L
Y
I
S
--------------------------------------------
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
---------
3
PsiBlast_PDB
95.16
45%
-108
- C3 -
1EP3
2
PYRK_LACLM
B:
[4-262]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
M
M
T
V
V
S
Q
R
E
V
-----
A
Y
N
--------------
I
F
E
M
V
L
K
---
G
T
L
---
V
---
D
E
M
-
D
L
P
G
Q
F
L
H
L
A
--
V
P
N
--
G
-----------------------------
A
-----------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
----
A
K
T
C
T
I
L
Y
R
I
G
D
E
-----------------
T
--
T
--
G
-
T
-
Y
K
L
S
-
K
-
L
E
S
G
-
A
K
V
-
D
V
M
-
G
P
L
G
N
G
-------
F
P
V
A
E
V
-------
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
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L
A
K
Q
L
E
K
T
-------
G
-----
C
Q
--
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
----
S
N
L
K
N
V
----------
T
L
--
K
--
I
--
A
--
T
D
----------
D
------
G
------
S
----
Y
G
T
K
G
H
V
--
G
M
--
L
M
-----
N
-------
E
I
-----
D
-----
F
E
V
-
D
A
-
L
Y
T
C
G
-
A
P
A
M
L
K
--
A
V
A
-
K
-
K
Y
-
D
Q
L
E
---
R
L
Y
I
S
--------------------------------------------
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
---------
52
Fugue
94.76
46%
-107
- C3 -
1EP3
2
PYRK_LACLM
B:
[2-262]
----------------------------------------------------------------------------------------------------------------------------------------------------S
Q
L
Q
E
M
M
T
V
V
S
Q
R
E
V
-----
A
Y
N
--------------
I
F
E
M
V
L
K
---
G
T
L
---
V
---
D
E
M
D
L
-
P
G
Q
F
L
H
L
A
--
V
P
N
--
G
-----------------------------
A
-----------
M
L
L
R
R
P
I
S
I
S
S
W
D
K
R
----
A
K
T
C
T
I
L
Y
R
I
--
G
-----------------
D
--
E
TT
G
-
T
-
Y
K
L
S
-
K
-
L
E
S
G
-
A
K
V
-
D
V
M
-
G
P
L
G
N
G
-------
F
P
V
A
E
V
-------
T
S
T
D
K
I
L
I
I
G
G
G
I
G
V
P
P
L
Y
E
L
A
K
Q
L
E
K
T
-------
G
-----
C
Q
--
M
T
I
L
L
G
F
A
S
E
N
V
K
I
L
E
N
E
F
----
S
N
L
K
N
V
----------
T
L
--
K
--
I
--
A
--
T
D
----------
D
------
G
------
S
----
Y
G
T
K
G
H
V
--
G
M
--
L
M
-----
N
-------
E
I
-----
D
-----
F
E
V
-
D
A
-
L
Y
T
C
G
-
A
P
A
M
L
K
--
A
V
A
-
K
-
K
Y
D
Q
L
-
E
---
R
L
Y
I
S
--------------------------------------------
M
E
S
R
M
A
C
G
I
G
A
C
Y
A
C
V
E
H
D
K
E
D
E
S
H
A
L
K
-
V
C
E
D
G
P
V
F
L
G
K
Q
L
S
L
---------
5
PsiBlast_PDB
80.97
30%
-101
- C3 -
4YRY
3
?
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
V
K
K
V
K
I
-----
A
E
D
--------------
V
F
D
F
W
I
H
---
S
P
S
---
V
---
S
K
E
-
A
R
P
G
Q
F
V
V
I
R
--
L
H
E
--
K
-----------------------------
G
-------------
E
R
I
P
L
T
V
A
D
T
K
P
E
----
E
G
L
F
R
M
V
V
K
V
--
V
-----------------
G
--
K
--
T
-
T
-
H
E
L
S
-
L
-
K
K
E
G
-
D
T
I
L
D
V
V
-
G
P
L
G
N
P
-------
S
E
I
E
N
Y
----------
G
N
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
-------
G
-----
N
N
--
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
----
K
E
I
S
------------
D
V
--
L
--
L
--
V
--
T
D
----------
D
------
G
------
S
----
A
G
M
K
G
V
V
--
T
D
A
-
M
D
-----
K
-------
L
F
-----
R
-----
E
R
K
F
D
I
-
C
W
A
V
G
-
P
T
I
M
M
K
F
C
T
L
K
-
A
-
R
E
-
F
G
-
V
---
P
I
W
V
S
--------------------------------------------
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
----
V
S
G
Q
I
K
F
A
C
V
D
G
P
E
F
R
G
E
E
V
-----------
4
PsiBlast_PDB
78.41
30%
-100
- C3 -
4YLF
2
?
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
V
K
K
V
K
I
-----
A
E
D
--------------
V
F
D
F
W
I
H
---
S
P
S
---
V
---
S
K
E
-
A
R
P
G
Q
F
V
V
I
R
--
L
H
E
--
K
-----------------------------
G
-------------
E
R
I
P
L
T
V
A
D
T
K
P
E
----
E
G
L
F
R
M
V
V
K
V
--
V
-----------------
G
--
K
--
T
-
T
-
H
E
L
S
-
L
-
K
K
E
G
-
D
T
I
L
D
V
V
-
G
P
L
G
N
P
-------
S
E
I
E
N
Y
----------
G
N
V
L
L
V
G
G
G
V
G
I
A
T
L
Y
P
I
A
K
A
L
K
E
A
-------
G
-----
N
N
--
I
T
T
V
L
G
A
R
T
K
D
Y
L
I
M
V
D
E
F
----
K
E
I
S
------------
D
V
--
L
--
L
--
V
--
T
D
----------
D
------
G
------
S
----
A
G
M
K
G
V
V
--
T
D
A
-
M
D
-----
K
-------
L
F
-----
R
-----
E
R
K
F
D
I
-
C
W
A
V
G
-
P
T
I
M
M
K
F
C
T
L
K
-
A
-
R
E
-
F
G
-
V
---
P
I
W
V
S
--------------------------------------------
L
N
P
I
M
V
D
G
T
G
M
C
G
A
C
R
V
T
----
V
S
G
Q
I
K
F
A
C
V
D
G
P
E
F
R
G
E
E
V
-----------
35
HHSearch
75.10
26%
-97
* C3 *
2R6H
4
?
A:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
W
E
C
E
V
L
S
N
K
N
V
-----
S
T
F
--------------
I
K
E
F
V
V
K
---
L
P
E
G
E
-
T
---
M
N
F
-
K
-
S
G
S
Y
A
Q
I
K
--
I
P
K
--
Y
N
I
R
YAD
Y
D
I
Q
DRFR
G
D
W
D
K
M
DAWS
L
T
C
K
N
E
-----------
E
E
T
V
R
A
Y
S
M
A
N
Y
P
A
E
----
G
N
I
I
T
L
N
V
R
I
--
A
TPPFDRAANKWKAGIKP
G
--
I
--
S
-
S
-
S
Y
I
F
-
S
-
L
K
P
G
-
D
K
V
-
M
M
S
-
G
P
Y
G
D
--------
F
H
I
Q
D
T
---------
D
A
E
M
L
Y
I
G
G
G
A
G
M
A
P
L
R
A
Q
I
L
H
L
F
R
T
LKT----
G
-----
R
K
--
V
S
Y
W
Y
G
A
R
S
K
N
E
I
F
Y
E
E
D
F
----
R
E
I
E
R
E
F
P--------
N
F
K
F
H
--
I
--
A
L
-
S
D
PQPE------
D
------
N
------
W
----
T
G
Y
V
G
F
I
--
H
Q
V
-
I
Y
-----
D
-------
N
Y
-----
L
KDHDA
P
E
D
-
I
E
-
Y
Y
M
C
G
-
P
G
P
M
A
N
--
A
V
K
-
G
-
M
L
-
E
N
-
L
GVP
R
N
M
L
F
--------------------------------------------
F
D
D
F
-------------------------------------------------
41
HHSearch
72.61
23%
-101
- C3 -
3W5H
5
NB5R3_PIG
A:
[13-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
P
L
R
L
I
D
K
E
V
V
-----
N
H
D
--------------
T
R
R
F
R
F
A
---
L
P
S
PEH
I
---
L
G
L
-
P
-
V
G
Q
H
I
Y
L
S
--
A
R
I
--
D
-----------------------------
G
-----------
N
L
V
I
R
P
Y
T
P
V
S
S
D
D
D
----
K
G
F
V
D
L
V
I
K
V
--
Y
FKDTHPKFPAG------
G
--
K
--
M
-
S
-
Q
Y
L
E
-
S
-
M
K
I
G
-
D
T
I
-
E
F
R
-
G
P
N
G
L
L
VYQGKG
K
F
A
I
R
P
D
KKSS
P
V
I
K
T
V
K
S
V
G
M
I
A
G
G
T
G
I
T
P
M
L
Q
V
I
R
A
I
M
K
D
P
DD----
H
-----
T
V
--
C
H
L
L
F
A
N
Q
T
E
K
D
I
L
L
R
P
E
L
----
E
E
L
R
N
E
HSA-------
R
F
--
K
L
W
Y
--
T
--
V
D
----------
R
APE---
A
------
W
----
D
Y
S
Q
G
F
V
--
N
E
E
-
M
I
-----
R
-------
D
H
-----
L
PPP--
E
E
E
-
P
L
-
V
L
M
C
G
-
P
P
P
M
I
Q
--
Y
A
C
L
P
-
N
L
-
E
R
-
V
---------------------------------------------------------------------------------------------------------
56
Fugue
71.07
20%
-94
- C3 -
1GVH
5
HMP_ECOLI
A:
[1-396]
MLD
A
Q
T
I
A
T
V
K
A
T
I
P
L
L
V
E
T
G
P
K
L
T
A
H
F
Y
D
R
M
F
T
H
N
PELKEIFNMSNQRNG
D
Q
R
E
A
L
F
N
A
I
A
A
Y
A
S
N
IENLPAL
L
P
A
V
E
K
I
A
Q
K
H
T
S
F
QIK
P
E
Q
Y
N
I
V
G
E
H
L
L
A
T
L
D
E
M
FSPG
Q
E
V
L
D
A
W
G
K
A
Y
G
V
L
A
N
V
F
I
N
R
E
A
E
I
Y
N
E
N
A
S
KAGGW
E
G
T
R
D
F
R
I
V
A
K
T
P
R
-----
S
A
L
--------------
I
T
S
F
E
L
E
P
VD
G
G
A
---
V
---
A
E
Y
-
R
-
P
G
Q
Y
L
G
V
W
L
K
P
E
G
--
F
-----------------------------
P
-----------
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
----
K
G
Y
R
I
A
V
K
R
E
--
E
G----------------
G
--
Q
--
V
-
S
-
N
W
L
H
-
N
H
A
N
V
G
-
D
V
V
-
K
L
V
-
A
P
A
G
D
--------
F
F
M
A
V
A
-------
D
-
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
A
K
A
-------
G
-----
H
T
A
Q
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
----
K
E
L
G
Q
S
LP--------
R
F
--
T
--
A
--
H
--
T
W
Y
RQPS
E
A
D
R
A
K
------
G
------
Q
----
F
D
S
E
G
L
M
DL
S
K
--
L
E
-----
G
-------
A
F
-----
S
-----
D
P
T
-
M
Q
-
F
Y
L
C
G
-
P
V
G
F
M
Q
--
F
T
A
-
K
-
Q
L
-
V
D
-
L
---
G
V
------------------------------------------------------------------------------------
K
Q
E
N
I
H
Y
E
C
FGPHKVL
40
HHSearch
67.52
21%
-105
- C3 -
2EIX
8
?
A:
[11-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
K
F
M
L
R
E
K
Q
I
I
-----
N
H
N
--------------
T
R
L
F
R
F
N
---
L
H
H
---
P
EDV
V
G
L
-
P
-
I
G
Q
H
M
S
V
K
--
A
T
V
--
D
-----------------------------
G
-----------
K
E
I
Y
R
P
Y
T
P
V
S
S
D
D
E
----
K
G
Y
F
D
L
I
I
K
V
--
Y
EK---------------
G
--
Q
--
M
-
S
-
Q
Y
I
D
-
H
-
L
N
P
G
-
D
F
L
-
Q
V
R
-
G
P
K
G
Q
--------
F
D
Y
K
P
N
--------
M
V
K
E
M
G
M
I
A
G
G
T
G
I
T
P
M
L
Q
V
A
R
A
I
I
K
N
PKE----
K
-----
T
I
--
I
N
L
I
F
A
N
V
N
E
D
D
I
L
L
R
T
E
L
----
D
D
M
A
K
K
Y
S--------
N
F
K
V
Y
--
Y
--
V
L
-
N
N
P---------
P
A-----
G
------
W
----
T
G
G
V
G
F
V
--
S
A
D
-
M
I
-----
K
-------
Q
H
-----
F
SPP--
S
S
D
-
I
K
-
V
M
M
C
G
-
P
P
M
M
N
K
--
A
M
Q
-
G
-
H
L
-
E
T
-
L
---------------------------------------------------------------------------------------------------------
38
HHSearch
67.29
22%
-105
- C3 -
2CND
1
A:
[12-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
H
C
R
L
V
A
K
K
E
L
-----
S
R
D
--------------
V
R
L
F
R
F
S
---
L
P
S
PDQ
V
---
L
G
L
-
P
-
I
G
K
H
I
F
V
C
--
A
T
I
--
E
-----------------------------
G
-----------
K
L
C
M
R
A
Y
T
P
T
S
M
V
D
E
----
I
G
H
F
D
L
L
V
K
V
--
Y
FKNEHPKFPNG------
G
--
L
--
M
-
T
-
Q
Y
L
D
-
S
-
L
P
V
G
-
S
Y
I
-
D
V
K
-
G
P
L
G
H
V
EYTGRG
S
F
V
I
N
G
K
Q
------
R
N
A
R
R
L
A
M
I
C
G
G
S
G
I
T
P
M
Y
Q
I
I
Q
A
V
L
R
D
QPED---
H
-----
T
E
--
M
H
L
V
Y
A
N
R
T
E
D
D
I
L
L
R
D
E
L
----
D
R
W
A
A
E
YPD-------
R
L
--
K
V
W
Y
--
V
--
I
D
----------
Q
VKRPEE
G
------
W
----
K
Y
S
V
G
F
V
--
T
E
A
-
V
L
-----
R
-------
E
H
-----
V
PEG--
G
D
D
-
T
L
-
A
L
A
C
G
-
P
P
P
M
I
Q
--
F
A
I
-
S
P
N
L
-
E
K
-
M
---------------------------------------------------------------------------------------------------------
30
HHSearch
66.61
20%
-101
- C3 -
2PIA
2
PDR_BURCE
A:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
R
L
K
I
A
S
K
E
K
I
-----
A
R
D
--------------
I
W
S
F
E
L
T
---
D
P
Q
---
G
AP
L
P
P
F
-
E
-
A
G
A
N
L
T
V
A
--
V
P
---------------------------------------------
N
G
S
R
R
T
Y
S
L
C
N
D
S
Q
E
----
R
N
R
Y
V
I
A
V
K
R
--
D
SN---------------
G
--
R
--
G
G
S
I
S
F
I
D
-
D
-
T
S
E
G
-
D
A
V
-
E
V
S
-
L
P
R
N
E
--------
F
P
L
D
K
R
---------
A
K
S
F
I
L
V
A
G
G
I
G
I
T
P
M
L
S
M
A
R
Q
L
R
A
E
G------
L
-----
R
S
--
F
R
L
Y
Y
L
T
R
D
P
E
G
T
A
F
F
D
E
L
----
T
S
D
E
WRS---------
D
V
--
K
--
I
--
H
--
H
D
----------
H
------
G
------
D
------
P
T
K
A
F
--
D
F
W
S
V
F
-----
E
-------
K
------
S
-----
K
P
A
-
Q
H
-
V
Y
C
C
G
-
P
Q
A
L
M
D
--
T
V
R
-
D
-
M
T
-
G
H
-
W
P--
S
G
T
V
H
F
E
S
FGATNTNAR
E
N
T
P
F
T
V
R
L
SRSG
T
S
F
E
I
P
ANRS
I
L
E
V
L
R
D
A
N
V
R
V
P
S
S
C
E
S
G
T
C
G
S
C
K
T
A
L
C
S
G
-------------------------------
39
HHSearch
61.66
20%
-84
- C3 -
2QDX
2
?
A:
[3-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
T
E
R
V
L
S
V
H
H
W
-----
N
D
T
--------------
L
F
S
F
K
T
T
---
R
N
P
---
G
---
L
R
F
-
K
-
T
G
Q
F
V
M
I
G
--
L
E
V
--
D
-----------------------------
G
-----------
R
P
L
M
R
A
Y
S
I
A
S
P
N
Y
E
-----
E
H
L
E
F
F
S
I
K
V
P
D
-----------------
G
--
P
--
L
-
T
-
S
R
L
Q
-
H
-
L
K
E
G
-
D
E
L
-
M
V
S
R
K
P
T
G
T
--------
L
V
H
D
D
L
-------
L
P
G
K
H
L
Y
L
L
S
T
G
T
G
M
A
P
F
L
S
V
I
Q
D
P
E
T
Y
E
R
-----
Y
-----
E
K
--
V
I
L
V
H
G
V
R
W
V
S
E
L
A
Y
A
D
F
I
----
T
K
V
L
PEHEYF
G
D
Q
V
K
E
K
L
--
I
--
Y
Y
P
L
--
V
T
----------
R
------
E
------
P
----
F
R
N
Q
G
R
Q
--
T
D
L
-
M
R
S
G
K
L
F
E
-------
D
I
GLPPM
N
-----
P
Q
D
-
D
R
-
A
M
I
C
G
-
S
P
S
M
L
E
--
E
T
S
-
A
-
V
L
-
D
S
-
F
---------------------------------------------------------------------------------------------------------
49
HHSearch
61.48
18%
-93
- C3 -
2B5O
6
FENR_SYNP2
A:
[122-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
L
G
K
C
I
E
N
Y
E
L
VDEGG
S
G
T
--------------
V
R
H
V
T
F
D
---
I
S
E
G--
D
---
L
R
Y
-
L
-
E
G
Q
S
I
G
I
I
--
P
P
G
--
E
DKNG-------------------------
K
-----------
P
H
K
L
R
L
Y
S
I
A
S
T
R
H
G
DMED
N
K
T
V
S
L
C
V
R
Q
--
L
E
Y
Q
D
PESG
E
T
V
Y
-----
G
--
V
--
C
-
S
-
T
Y
L
C
-
N
-
L
P
V
G
T
D
D
V
-
K
I
T
-
G
P
V
G
K
E
-------
M
L
L
P
D
D
--------
E
D
A
T
V
V
M
L
A
T
G
T
G
I
A
P
F
R
A
F
L
W
R
M
F
K
E
QHEDYKF
K
-----
G
K
--
A
W
L
I
F
G
V
P
Y
T
A
N
I
L
Y
K
D
D
F
----
E
K
M
A
A
E
N
PD-------
N
F
R
L
T
--
Y
A
-
I
--
S
R
E---------
Q
K-----
T
ADGG--
K
----
V
Y
V
Q
S
R
V
--
S
E
--
Y
A
-----
D
-------
E
L
F
E
M
--
I
Q
----
K
P
N
-
T
H
-
V
Y
M
C
G
-
L
K
G
M
Q
P
--
P
I
D
-
E
-
T
F
-
T
A
-----------------------------------------------------------------------------------------------------------
33
HHSearch
61.44
17%
-93
- C3 -
1FDR
1
FENR_ECOLI
A:
[3-228]
------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
V
T
G
K
V
T
K
V
Q
N
W
-----
T
D
A
--------------
L
F
S
L
T
V
H
---
A
P
----
V
---
L
P
F
-
T
-
A
G
Q
F
T
K
L
G
--
L
E
I
---------------------------------------------
R
V
Q
R
A
Y
S
Y
V
N
S
P
D
N
-----
P
D
L
E
F
Y
L
V
T
--
V
PD---------------
G
--
K
--
L
-
S
-
P
R
L
A
-
A
-
L
K
P
G
-
D
E
V
-
Q
V
V
-
S
E
A
A
G
F
-------
F
V
L
D
E
V
-------
P
H
C
E
T
L
W
M
L
A
T
G
T
A
I
G
P
Y
L
S
I
L
R
L
G
K
D
L
DR-----
F
-----
K
N
--
L
V
L
V
H
A
A
R
Y
A
A
D
L
S
Y
L
P
L
M
----
Q
E
L
E
K
R
Y
E
G-------
K
L
--
R
I
Q
T
--
V
V
S
R
E
----------
T
------
A
------
A
----
G
S
L
T
G
R
I
--
P
A
--
L
I
E
----
S
-------
G
E
L
E
S
T
-
I
G
L
P
M
N
K
E
T
-
S
H
-
V
M
L
C
G
-
N
P
Q
M
V
R
--
D
T
Q
-
Q
-
L
L
-
K
E
-
T
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.35
25%
-130
- C3 -
2EIX
7
?
A:
[37-230]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
---
V
---
V
G
L
-
P
-
I
G
Q
H
M
S
V
K
--
A
T
V
--
D
-----------------------------
G
-----------
K
E
I
Y
R
P
Y
T
P
V
S
S
D
D
E
----
K
G
Y
F
D
L
I
I
K
V
Y
E
K
-----------------
G
--
Q
--
M
-
S
-
Q
Y
I
D
-
H
-
L
N
P
G
-
D
F
L
-
Q
V
R
-
G
P
K
G
Q
--------
F
D
Y
K
P
N
-------
M
V
-
K
E
M
G
M
I
A
G
G
T
G
I
T
P
M
L
Q
V
A
R
A
I
I
K
N
-------
P
KEK
T
I
I
N
--
L
I
F
A
N
--
V
N
E
D
D
I
L
L
R
T
E
L
D
D
M
A
K
K
Y
S
------------
N
F
--
K
--
V
--
Y
--
Y
V
L
NNPP-----
A
------
G
------
W
----
T
G
G
V
G
F
V
--
S
A
D
M
I
K
-----
Q
-------
H
F
S----
P
-----
P
S
S
-
D
I
K
V
M
M
C
G
-
P
P
M
M
N
K
--
A
M
Q
-
G
-
H
L
--------------------------------------------------------------------------------------------------------------
43
HHSearch
60.90
18%
-78
- C3 -
1GVH
4
HMP_ECOLI
A:
[153-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
R
I
V
A
K
T
P
R
-----
S
A
L
--------------
I
T
S
F
E
L
E
---
P
V
D
---
G
G
A
V
A
E
Y
-
R
-
P
G
Q
Y
L
G
V
W
--
L
K
P
--
E
-----------------------------
G
FP---------
H
Q
E
I
R
Q
Y
S
L
T
R
K
P
D
G
-----
K
G
Y
R
I
A
V
K
R
--
E
EG---------------
G
--
Q
--
V
-
S
-
N
W
L
H
-
N
H
A
N
V
G
-
D
V
V
-
K
L
V
-
A
P
A
G
D
--------
F
F
M
A
V
A
--------
D
D
T
P
V
T
L
I
S
A
G
V
G
Q
T
P
M
L
A
M
L
D
T
L
A
K
A
GH-----
T
-----
A
Q
--
V
N
W
F
H
A
A
E
N
G
D
V
H
A
F
A
D
E
V
----
K
E
L
G
Q
S
LP--------
R
F
T
A
H
T
-
W
--
Y
--
R
Q
P---------
S
------
E
A
D
R
A
K
G
Q
----
F
D
S
E
G
L
M
--
D
L
S-
K
L
-----
E
-------
G
A
-----
F
S----
D
P
T
-
M
Q
-
F
Y
L
C
G
-
P
V
G
F
M
Q
--
F
T
A
-
K
-
Q
L
-
V
D
-
L
GVK
Q
E
N
I
H
--------------------------------------------
Y
E
C
F
G
P
-----------------------------------------------
44
HHSearch
60.76
20%
-98
- C3 -
1CQX
2
HMP_CUPNH
A:
[155-398]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
F
V
I
R
E
K
R
P
E
-----
S
D
V
--------------
I
T
S
F
I
L
E
---
P
A
D
G
G
P
V
---
V
N
F
-
E
-
P
G
Q
Y
T
S
V
A
--
I
D
V
PA
L
-----------------------------
G
-----------
L
Q
Q
I
R
Q
Y
S
L
S
D
M
P
N
-----
G
R
T
Y
R
I
S
V
K
R
--
E
GGGPQPP----------
G
--
Y
--
V
-
S
-
N
L
L
H
D
H
-
V
N
V
G
-
D
Q
V
-
K
L
A
-
A
P
Y
G
S
--------
F
H
I
D
V
D
--------
A
K
T
P
I
V
L
I
S
G
G
V
G
L
T
P
M
V
S
M
L
K
V
A
L
Q
A
P------
P
-----
R
Q
--
V
V
F
V
H
G
A
R
N
S
A
V
H
A
M
R
D
R
L
----
R
E
A
A
K
T
YE--------
N
L
D
L
F
--
V
--
F
Y
-
D
Q
----------
P
LPE---
D
------
V
QGRD
Y
D
Y
P
G
L
V
--
D
V
K-
Q
I
-----
E
-------
K
S
-----
I
L----
L
P
D
-
A
D
-
Y
Y
I
C
G
-
P
I
P
F
M
R
--
M
Q
H
-
D
-
A
L
-
K
N
-
L
GIH
E
A
R
I
H
--------------------------------------------
Y
E
V
F
G
P
-----------------------------------------------
46
HHSearch
60.65
19%
-97
- C3 -
2RC5
3
?
A:
[21-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
A
K
V
I
S
N
V
L
L
-----
T
P
E
TGTGKRPKKE
G
E
A
L
V
H
R
I
V
L
A
---
I
D
H
S--
A
---
Y
P
Y
-
V
-
I
G
Q
S
G
G
V
I
--
P
P
G
--
E
-----------------------------
D
P
E
K
K
A
K
GLADV
G
Y
T
V
R
L
Y
S
I
A
S
P
S
Y
S
FGMK
E
D
N
I
E
F
I
I
K
R
--
D
NIYNGNIQ
F
K
-------
G
--
V
--
C
-
S
-
N
Y
M
C
-
D
-
L
K
P
G
-
D
E
V
-
T
M
T
-
G
P
S
G
K
K
-------
F
L
L
P
N
T
-------
D
F
S
G
D
I
M
F
L
A
T
G
T
G
I
A
P
F
I
G
M
S
E
E
L
L
E
H
-------
K
LIKFT
G
N
--
I
T
L
V
Y
G
A
P
Y
S
D
E
L
V
M
M
D
Y
L
----
K
G
L
E
S
K
H
K--------
N
F
K
L
I
--
T
--
A
I
-
S
R
E---------
E
KN----
S
------
F
----
D
G
G
R
M
Y
I
--
S
H
--
R
V
-----
R
E
Q
A
E
A
V
K
K
I
-----
L
-----
N
G
G
-
G
R
-
F
Y
I
C
G
G
P
K
G
M
E
K
--
G
V
I
-
E
-
E
I
-
Q
K
-
I
S
--
G
N
T
G
T
--------------------------------------------
Y
E
E
F
K
H
H
L
---------------------------------------------