@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0113: (2015-11-28 )
MYSAVIVKPKRNVFAVLDIGTTKIICLIVKVSGNFNYKITGTGYKIAEGINGGLITDIKYASYSISSTIGLAEQVSEETIDQIYVNIAGCGILSFNVHNEIIAANHEISDRDIKRVIFQTFEKYIEENVIIHNIPLRYHLDDMTDIREVSGLYGKRLSADVNVVTASRPALTNIENCITNNSGISMAGCIASAYSAGFACLSEDEKELGTAIVDIGGGCTAIGIFKRSKLIYANSIPIGGVHITRDIAYGLCTSIEHAERIKILYGSTVVTSIDENEYITVQSNENDEQARIPKSELVDIIRPRIEEILELVKEQFRKQKDPINKVVITGGTSRLASMKEIASYIFNKQVRIGCPESYGGLDGEYNKNPVFSAAIGSIKLIVDTFYKNNPDMLGQDGKISKLYHWVKSKVTV
Atome Classification :
(20 SA)
.........10........20-....-.....30........40........50....-..-..60........70........80---........--90.-.......100.---..---.....-110.-......120.-.--..-...130...------....140......------.-150...-.-...160.-......---.----170..------.....180-----------------------...--......190.......200--..-------.....210.......220-...----.--...230----.-----.--.....-----.240......-..250..-------------------.-------------------..-------..260.......270---------....-----.-..280-...------.--..-..290.-....---..300..------.....310......-----.320--....---------.----...330.......340......-.---350.....-..--360--.-------.--....-..370.......380----........390-........400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
S
A
V
I
V
KPKR
N
V
F
A
V
L
DIG--T
T
K
I
-
I
C
L
I
V
K
VSGNF
N
Y
K
I
TGTG
Y
K
IAEGING
G
L
I
-
T
D
-
I
K
Y
A
S
Y
SI
S
S
TI
G
L
A
E
Q
V
S
E
E
T
I
D
---
Q
I
Y
V
N
I
AG--
C
G
I
-
L
S
F
NVHN
E
I
-
I
---AA---NHEI
S
-
D
R
D
I
-
K
R
V
I
F
Q
T
F
E
K
-
Y
--
I
E-EN
V
I
I
HNI
P
------
L
R
Y
HLD
D
M
T
D
I
R
E
------
V
-
S
G
L
YGK-R-LSA
D
-
V
N
-
V
V
TASR---P----
A
L
T
N
I
------
E
N
C
ITN-------------------------NSG--
I
S
M
A
G
C
I
A
S
A
Y
S
AG
F
A
CLS--E
D
-------
E
K
E
L
G
T
A
I
V
DIGGG
C
T
A
I
-
G
I
F
----
K
--
R
S
K
L
I
-----
Y
-----A--NSIPI-----G
G
V
-
H
I
T
R
D
I
-
A
Y
G
L
C
T
S-------------------I-------------------E
H
-------
A
E
R
I
K
I
L
YG
S
T
V
V
T
S---------IDEN-----
E
-
Y
I
T
V
--QSN------E--N
D
-
E
QARI
P
-
K
S
E
L
---
V
D
I
I
R
P
R
------
I
E
E
I
L
E
L
V
K
E
Q
F
R
K
-----QKD---PI
N
K
---------
V
----
V
I
TGG
T
S
R
L
A
S
M
K
E
I
A
S
Y
I
FNK-
Q
---
V
RIGCPES-YG--GL---D-------G--EYNK-NPV
F
S
AAIG
S
I
K
L
I
-----
V
D
T
F
YKNN
P
D
--MLGQDG
K
I
S
K
L
Y
H
W
V
K
SKVTV
21
HHSearch
97.95
27%
-106
- C4 -
3WT0
1
FTSA_STAAW
A:
[20-391]
---------
E
E
H
Y
Y
V
S
I
D
I
G
--
S
S
S
V
-
K
T
I
V
G
E
K
F
H
-
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
K
N
G
L
I
-
D
D
-
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
---
E
V
F
L
K
L
P
I
IG
T
E
V
-
Y
D
E
S
----
N
-
E
---
I
D
F
Y
E
D
T
E
I
N
-
G
S
H
I
-
E
K
V
L
E
G
I
R
E
K
N
D
--
V
Q
-
E
T
E
V
I
N
V
F
P
------
I
R
F
I
V
D
K
E
N
E
V
S
D
------
P
-
K
E
L
I
A
R
H
S
-
L
K
V
E
-
A
G
-
V
I
A
I
Q
K
---
S
----
I
L
I
N
M
------
I
K
C
V
E
--------------------------
A
C
G
--
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
A
---
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
-
A
F
Y
----
E
--
R
G
E
L
V
-----
D
-----
A
--
D
S
I
E
M
-----
A
G
R
-
D
I
T
D
D
I
-
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
-------
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
---------
A
S
D
Q
-----
D
-
I
F
T
V
--
E
Q
V
------
D
--
S
D
-
E
T
V
Q
Y
T
-
Q
K
D
L
---
S
D
F
I
E
A
R
------
V
E
E
I
F
F
E
V
F
D
V
L
Q
D
L
G---
L
T
K
---
V
N
G
G
---------
F
----
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
---
V
R
I
H
T
P
S
Q
---------------------
M
G
I
R
-
K
P
E
F
S
S
A
I
S
T
I
S
S
S
-----
I
A
F
D
E
L
L
D
-------------------------
22
HHSearch
97.35
27%
-105
- C4 -
3WQT
4
FTSA_STAAR
A:
[20-389]
-----------
H
Y
Y
V
S
I
D
I
G
--
S
S
S
V
-
K
T
I
V
G
E
K
F
H
-
N
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
K
N
G
L
I
-
D
D
-
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
---
E
V
F
L
K
L
P
I
IG
T
E
V
-
Y
D
E
S
----
N
-
E
---
I
D
F
YE
D
T
E
I
N
-
G
S
H
I
-
E
K
V
L
E
G
I
R
E
------
Q
-
E
T
E
V
I
N
V
F
P
------
I
R
F
I
V
D
K
E
N
E
V
S
D
------
P
-
K
E
L
I
A
R
H
S
-
L
K
V
E
-
A
G
-
V
I
A
I
Q
K
---
S
----
I
L
I
N
M
------
I
K
C
V
E
--------------------------
A
C
G
--
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
S
I
L
T
A
---
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
-
A
F
Y
----
E
--
R
G
E
L
V
-----
D
-----
A
--
D
S
I
E
M
-----
A
G
R
-
D
I
T
D
D
I
-
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
-------
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
---------
A
S
D
Q
-----
D
-
I
F
T
V
--
E
Q
V
------
D
--
S
D
-
E
T
V
Q
Y
T
-
Q
K
D
L
---
S
D
F
I
E
A
R
------
V
E
E
I
F
F
E
V
F
D
V
L
Q
D
L
G---
L
T
K
---
V
N
G
G
---------
F
----
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
---
V
R
I
H
T
P
S
Q
---------------------
M
G
I
R
-
K
P
E
F
S
S
A
I
S
T
I
S
S
S
-----
I
A
F
D
E
L
L
D
-------------------------
2
PsiBlast_PDB
94.32
29%
-107
- C4 -
3WQT
3
FTSA_STAAR
A:
[20-369]
-----------
H
Y
Y
V
S
I
D
I
G
--
S
S
S
V
-
K
T
I
V
G
E
K
F
H
N
-
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
K
N
G
L
I
-
D
D
-
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
---
E
V
F
L
K
L
P
I
--
I
G
T
-
E
V
Y
D
E
S
N
E
I
D
F
---
Y
E
---
D
T
E
I
N
-
G
S
H
I
-
E
K
V
L
E
G
I
R
E
------
Q
-
E
T
E
V
I
N
V
F
P
------
I
R
F
I
V
D
K
E
N
E
V
S
D
------
P
-
K
E
L
I
A
R
-
H
S
L
K
V
E
-
A
G
-
V
I
A
I
Q
K
---
S
----
I
L
I
N
M
------
I
K
C
V
-
E
-------------------------
A
C
G
--
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
I
L
T
--
A
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
-
A
F
Y
----
E
--
R
G
E
L
V
-----
D
-----
A
--
D
S
I
E
M
-----
A
G
R
-
D
I
T
D
D
I
-
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
-------
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
---------
A
S
D
Q
-----
D
-
I
F
T
V
--
E
Q
V
------
D
--
S
D
-
E
T
V
Q
Y
T
-
Q
K
D
L
---
S
D
F
I
E
A
R
------
V
E
E
I
F
F
E
V
F
D
V
L
-------
Q
D
L
---
G
L
T
K
---------
V
NG
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
---
V
R
I
H
T
P
S
Q
-
M
G
--
I
R
---
K
-------
P
--
E
F
S
S
-
A
I
S
T
I
S
S
S
I
A
F
D
E
L
-----
L
D
-------------------------------
1
PsiBlast_PDB
93.73
29%
-105
- C4 -
3WT0
1
FTSA_STAAW
A:
[20-371]
---------
E
E
H
Y
Y
V
S
I
D
I
G
--
S
S
S
V
-
K
T
I
V
G
E
K
F
H
N
-
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
K
N
G
L
I
-
D
D
-
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
---
E
V
F
L
K
L
P
I
--
I
G
T
-
E
V
Y
D
E
S
N
E
I
D
F
---
Y
E
---
D
T
E
I
N
-
G
S
H
I
-
E
K
V
L
E
G
I
R
E
K
-
N
D-
V
Q
-
E
T
E
V
I
N
V
F
P
------
I
R
F
I
V
D
K
E
N
E
V
S
D
------
P
-
K
E
L
I
A
R
-
H
S
L
K
V
E
-
A
G
-
V
I
A
I
Q
K
---
S
----
I
L
I
N
M
------
I
K
C
V
-
E
-------------------------
A
C
G
--
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
I
L
T
--
A
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
-
A
F
Y
----
E
--
R
G
E
L
V
-----
D
-----
A
--
D
S
I
E
M
-----
A
G
R
-
D
I
T
D
D
I
-
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
-------
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
---------
A
S
D
Q
-----
D
-
I
F
T
V
--
E
Q
V
------
D
--
S
D
-
E
T
V
Q
Y
T
-
Q
K
D
L
---
S
D
F
I
E
A
R
------
V
E
E
I
F
---
F
E
V
F
D
V
-----
L
Q
D
L
--
G
L
T
K
---------
V
NG
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
---
V
R
I
H
T
P
S
Q
-
M
G
--
I
R
---
K
-------
P
--
E
F
S
S
-
A
I
S
T
I
S
S
S
I
A
F
D
E
L
-----
L
D
-------------------------------
3
PsiBlast_PDB
93.68
29%
-107
- C4 -
3WQU
1
FTSA_STAAR
A:
[20-369]
-----------
H
Y
Y
V
S
I
D
I
G
--
S
S
S
V
-
K
T
I
V
G
E
K
F
H
N
-
G
I
N
V
I
G
T
G
Q
T
Y
T
S
G
I
K
N
G
L
I
-
D
D
-
F
D
I
A
R
Q
A
I
K
D
T
I
K
K
A
S
I
A
S
G
V
D
I
K
---
E
V
F
L
K
L
P
I
--
I
G
T
-
E
V
Y
D
E
S
N
E
I
D
F
---
Y
E
---
D
T
E
I
N
-
G
S
H
I
-
E
K
V
L
E
G
I
R
E
------
Q
-
E
T
E
V
I
N
V
F
P
------
I
R
F
I
V
D
K
E
N
E
V
S
D
------
P
-
K
E
L
I
A
R
-
H
S
L
K
V
E
-
A
G
-
V
I
A
I
Q
K
---
S
----
I
L
I
N
M
------
I
K
C
V
-
E
-------------------------
A
C
G
--
V
D
V
L
D
V
Y
S
D
A
Y
N
Y
G
-
S
I
L
T
--
A
T
-------
E
K
E
L
G
A
C
V
I
D
I
G
E
D
V
T
Q
V
-
A
F
Y
----
E
--
R
G
E
L
V
-----
D
-----
A
--
D
S
I
E
M
-----
A
G
R
-
D
I
T
D
D
I
-
A
Q
G
L
N
T
S
-------------------
Y
-------------------
E
T
-------
A
E
K
V
K
H
Q
Y
G
H
A
F
Y
D
S
---------
A
S
D
Q
-----
D
-
I
F
T
V
--
E
Q
V
------
D
--
S
D
-
E
T
V
Q
Y
T
-
Q
K
D
L
---
S
D
F
I
E
A
R
------
V
E
E
I
F
F
E
V
F
D
V
L
-------
Q
D
L
---
G
L
T
K
---------
V
NG
G
F
I
V
T
G
G
S
A
N
L
L
G
V
K
E
L
L
S
D
M
V
S
E
-
K
---
V
R
I
H
T
P
S
Q
-
M
G
--
I
R
---
K
-------
P
--
E
F
S
S
-
A
I
S
T
I
S
S
S
I
A
F
D
E
L
-----
L
D
-------------------------------
42
Fugue
85.68
20%
-98
- C4 -
1E4F
-
?
T:
[7-390]
----------
T
V
F
Y
T
S
I
D
I
G
--
S
R
Y
I
-
K
G
L
V
L
G
K
R
D
Q
-
E
W
E
A
L
A
F
S
S
V
K
S
R
G
L
D
E
G
E
I
-
K
D
-
A
I
A
F
K
E
S
V
N
T
L
L
K
E
L
E
E
Q
L
Q
K
S
L
R
SDF
V
I
S
F
S
S
V
S
--
F
E
R
-
E
D
T
V
I
E
R
D
F
-
G
---
E
E
---
K
R
S
I
T
-
L
D
I
L
-
S
E
M
Q
S
E
A
L
E
K
-
L
--
K
E
N
G
K
T
P
L
H
I
F
S
------
K
R
Y
L
L
D
D
E
R
I
V
F
N
------
P
-
L
D
M
K
A
S
-
K
-
I
A
I
E
-
Y
T
-
S
I
V
V
P
L
---
K
----
V
Y
E
M
F
------
Y
N
F
L
Q
D
-------------------------
T
-
V
--
K
S
P
F
Q
L
K
S
S
L
V
S
T
A
E
G
V
L
T
--
T
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
-
I
A
Y
----
K
--
N
G
V
P
I
-----
K
-----
I
--
S
Y
V
P
V
-----
G
M
K
-
H
V
I
K
D
V
-
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
-------
S
E
R
L
I
I
T
H
G
N
-
A
V
Y
N
---------
D
L
K
E
-----
E
-
E
I
Q
Y
--
R
G
L
------
D
--
G
N
-
T
I
K
T
T
T
-
A
K
K
L
---
S
V
I
I
H
A
R
------
L
R
E
I
M
S
K
S
K
K
F
F
R
E
-----
V
E
A
KIG
I
P
G
G
---------
V
----
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
---
V
R
T
G
C
Y
A
N
-
S
D
RP
S
I
---
I
-------
N
AD
E
V
A
N
-
D
P
S
F
A
A
A
F
G
N
V
F
A
---------------------------------------
23
HHSearch
75.51
15%
-108
- C4 -
2YCH
3
?
A:
[11-375]
---------
P
R
V
E
A
L
G
L
E
I
G
--
A
S
A
L
-
K
L
V
E
V
S
G
N
P
-
P
A
L
K
A
L
A
S
R
P
T
P
P
G
L
L
M
E
G
M
V
-
A
E
-
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
----
R
T
R
K
R
---
Y
V
V
T
A
L
S
N
--
L
A
V
-
I
L
R
P
----
I
-
Q
---
V
P
-----
K
M
P
-
L
K
E
M
-
E
E
A
V
R
W
E
A
E
R
Y
I
PF
P
I
--
E
V
V
L
D
F
A
P
------
L
T
P
L
S
E
V
Q
E
-------------------
G
-
E
Q
V
Q
-
V
M
-
V
A
A
A
R
Q
---
E
----
A
V
A
G
V
------
L
E
A
L
R
--------------------------
G
A
G
--
L
V
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
A
E
-------
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
-
V
L
L
----
R
--
G
D
K
P
L
-----
A
-----
V
--
R
V
L
T
L
-----
S
G
K
-
D
F
T
E
A
I
-
A
R
S
F
N
L
D
-------------------
L
-------------------
L
A
-------
A
E
E
V
K
R
T
Y
--------------------------------------------------------
G
R
I
---
Y
D
A
I
R
P
V
------
L
V
E
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
Q
L------
S
P
E
V
---------
G
----
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
-
N
---
L
E
P
V
N
P
W
E
A
V
A
V
-
D
P
KRF
E
S
E
-----
Q
--
L
Q
E
I
-
G
P
E
F
A
V
A
L
G
L
A
L
R
G
-----
V
E
P
------------------------------
7
PsiBlast_PDB
67.58
26%
-94
- C4 -
1E4G
1
?
T:
[189-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
V
S
T
A
E
G
V
L
T
--
T
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
-
I
A
Y
----
K
--
N
G
V
P
I
-----
K
-----
I
--
S
Y
V
P
V
-----
G
M
K
-
H
V
I
K
D
V
-
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
-------
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
---------
L
K
E
E
-----
E
--
I
Q
Y
--
R
G
L
------
D
--
G
N
-
T
I
K
T
T
T
-
A
K
K
L
---
S
V
I
I
H
A
R
------
L
R
E
I
M
S
K
S
K
K
F
F
R
E
-----
V
E
A
---
K
---GIPGG----
V
----
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
---
V
R
T
G
C
----
Y
A
--
N
S
---
D
RPSIINA
D
--
E
V
A
N
-
D
P
S
F
A
A
A
F
G
N
V
F
A
V
-----
S
--------------------------------
6
PsiBlast_PDB
67.41
26%
-87
- C4 -
4A2B
1
?
A:
[189-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
V
S
T
A
E
G
V
L
T
--
T
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
-
I
A
Y
----
K
--
N
G
V
P
I
-----
K
-----
I
--
S
Y
V
P
V
-----
G
M
K
-
H
V
I
K
D
V
-
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
-------
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
---------
L
K
E
E
-----
E
--
I
Q
Y
--
R
G
L
------
D
--
G
N
-
T
I
K
T
T
T
-
A
K
K
L
---
S
V
I
I
H
A
R
------
L
R
E
I
M
S
K
S
K
K
F
F
R
E
-----
V
E
A
---
K
I
V
E
E
GEIGIPG
G
V
----
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
---
V
R
T
G
C
----
Y
A
--
N
S
---
D
RPSIINA
D
--
E
V
A
N
-
D
P
S
F
A
A
A
F
G
N
V
F
A
V
-----
S
--------------------------------
4
PsiBlast_PDB
66.79
26%
-87
- C4 -
1E4F
-
?
T:
[189-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
V
S
T
A
E
G
V
L
T
--
T
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
-
I
A
Y
----
K
--
N
G
V
P
I
-----
K
-----
I
--
S
Y
V
P
V
-----
G
M
K
-
H
V
I
K
D
V
-
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
-------
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
---------
L
K
E
E
-----
E
--
I
Q
Y
--
R
G
L
------
D
--
G
N
-
T
I
K
T
T
T
-
A
K
K
L
---
S
V
I
I
H
A
R
------
L
R
E
I
M
S
K
S
K
K
F
F
R
E
-----
V
E
A
---
K
---IGIPGG---
V
----
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
---
V
R
T
G
C
----
Y
A
--
N
S
---
D
RPSIINA
D
--
E
V
A
N
-
D
P
S
F
A
A
A
F
G
N
V
F
A
---------------------------------------
5
PsiBlast_PDB
66.75
26%
-88
- C4 -
4A2A
2
?
A:
[189-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
L
V
S
T
A
E
G
V
L
T
--
T
P
-------
E
K
D
R
G
V
V
V
V
N
L
G
Y
N
F
T
G
L
-
I
A
Y
----
K
--
N
G
V
P
I
-----
K
-----
I
--
S
Y
V
P
V
-----
G
M
K
-
H
V
I
K
D
V
-
S
A
V
L
D
T
S
-------------------
F
-------------------
E
E
-------
S
E
R
L
I
I
T
H
G
N
A
V
Y
N
D
---------
L
K
E
E
-----
E
--
I
Q
Y
--
R
G
L
------
D
--
G
N
-
T
I
K
T
T
T
-
A
K
K
L
---
S
V
I
I
H
A
R
------
L
R
E
I
M
S
K
S
K
K
F
F
R
E
-----
V
E
A
---
K
---IPG
G
-----
V
----
V
L
T
G
G
G
A
K
I
P
R
I
N
E
L
A
T
E
V
F
K
S
-
P
---
V
R
T
G
C
----
Y
A
--
N
S
---
D
RPSIINA
D
--
E
V
A
N
-
D
P
S
F
A
A
A
F
G
N
V
F
A
---------------------------------------
44
Fugue
66.54
13%
-82
- C4 -
2YCH
3
?
A:
[11-375]
---------
P
R
V
E
A
L
G
L
E
I
G
--
A
S
A
L
-
K
L
V
E
V
S
---
G
N
P
P
A
L
K
A
L
A
S
R
P
---
T
P
P
G
L
L
M
E
G
M
V
A
E
P
A
A
L
A
Q
E
I
K
E
L
L
L
E
A
R
T
R
K
---------
R
Y
V
V
--
T
A
L
-
S
N
L
A
V
I
L
R
P
-
I
---
Q
V
---
P
---
K
M
P
L
K
E
M
E
E
A
V
R
W
E
A
E
R
-
Y
--
I
P
------
F
P
I
E
------
V
V
L
D
F
A
P
L
T
P
L
S
E
------------
V
Q
-
E
-
G
E
Q
V
-
Q
V
M
V
A
A
A
R
Q
---
E
----
A
V
A
G
V
------
L
E
A
L
R
G
A
------------------------
G
L
V
--
P
V
V
L
D
V
K
P
F
A
G
L
Y
P
L
E
A
R
L
--
A
E
-------
E
P
D
R
V
F
L
V
L
D
I
G
A
E
S
T
S
L
-
V
L
L
----
R
--
G
D
K
P
L
-----
A
-----
V
--
R
V
L
T
L
-----
S
G
K
-
D
F
T
E
A
I
-
A
R
S
F
N
L
D
-------------------
L
-------------------
L
A
-------
A
E
E
V
K
R
T
Y
G
----------------------------------------------------
R
-
I
Y
D
A
---
I
R
P
V
L
V
E
------
L
T
Q
E
L
R
R
S
L
E
F
F
R
I
-----
Q
-
L
---
S
P
E
V
---------
G
----
Y
L
L
G
G
G
S
K
L
R
G
L
A
S
L
L
T
D
T
L
G
V
-
N
---
L
E
P
V
N
P
W
E
-
A
V
--
A
V
---
D
-------
P
--
K
R
F
E
-
S
E
Q
L
Q
E
I
G
P
E
F
A
V
A
-----
L
G
L
A
L
R
G
V
E
P
-----------------------
31
HHSearch
58.87
21%
-83
- C4 -
3I33
3
HSP72_HUMAN
A:
[160-401]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
-
V
I
T
V
P
A
---
Y
FN
D
S
Q
R
Q
A
T
------
K
D
A
G
T
--------------------------
I
T
G
--
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
KGCA---
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
-
S
I
L
----
T
I
E
D
G
I
F
E
-----
V
K
S
T
--
A
--
G
D
T
H
L
-----
G
G
E
-
D
F
D
N
R
M
-
V
S
H
L
A
E
E
F
K
R
K
HKKDIGPN
K
R
A
V
R
R
L
R
-------------------
T
A
-------
C
E
R
A
K
R
T
L
S
S
S
T
Q
--------------------
A
-
S
I
E
I
--
D
S
L
------
Y
EG
V
D
-
F
Y
T
S
I
T
-
R
A
R
F
---
E
E
L
N
A
D
L
------
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
KL--
D
K
G
---
Q
I
Q
E
---------
I
----
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
---
L
N
--
K
--------------------------
S
I
-
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
A
I
L
I
-----------------------------
45
Fugue
57.03
15%
-72
- C4 -
1T6C
11
?
A:
[10-315]
---------
P
I
M
R
V
A
S
I
D
I
G
--
S
Y
S
V
-
R
L
T
I
A
Q
I
K
D
G
K
L
S
I
I
L
E
R
G
R
I
T
--
S
L
G
T
K
V
K
-
E
T
-
G
R
L
Q
E
D
R
I
E
E
T
I
Q
V
L
K
E
Y
K
K
L
I
D
E
-------------------
F
K
V
E
R
V
K
-
A
---
V
A
---
T
E
A
I
R
-
R
A
K
N
-
A
E
E
F
L
E
R
V
K
R
-
E
--
V
---------------------------------------------------------------------------------------------------------------
G
L
V
--
V
E
V
I
T
P
E
Q
E
G
R
Y
A
Y
L
A
V
A
Y
--
S
L
-------
K
P
E
G
E
V
C
V
V
D
Q
G
G
G
S
T
E
Y
-
V
F
G
----
K
--
G
Y
K
V
R
-----
E
-----
V
--
I
S
L
P
I
-----
G
I
V
-
N
L
T
E
T
F
-
F
K
Q
D
P
P
T
-------------------
E
-------------------
E
E
-------
V
K
R
F
F
E
F
L
E
K
E
L
S
K
V
---------
K
K
P
V
-----
D
-
T
I
V
G
--
L
G
--------------------------------
G
T
------
I
T
T
L
A
A
L
E
Y
N
V
Y
P
Y
-----
D
P
Q
---
K
V
H
G
---------
K
----
V
L
T
-----
Y
G
Q
I
K
K
W
F
D
T
F
K
E
I
-
P
---
S
E
E
R
S
K
R
F
-
R
Q
--
V
---------------
E
D
R
R
-
A
K
V
I
L
A
G
I
G
I
F
L
K
T
-----
L
E
I
F
E
K
D
C
L
I
--
V
S
D
W
G
L
R
E
G
V
L
V
S
E
V
L
K
E
N
H
S
30
HHSearch
56.05
22%
-72
- C4 -
3D2F
3
?
A:
[152-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
Q
R
Y
N
I
------
A
D
A
A
R
--------------------------
I
A
G
--
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
--
F
K
TDLPEGE
E
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
-
S
I
M
----
A
F
K
K
G
Q
L
K
V
L
G
--
T
-----
A
--
C
D
K
H
F
-----
G
G
R
-
D
F
D
L
A
I
-
T
E
H
F
A
D
E
F
K
T
K
YKIDIREN
P
K
A
Y
N
R
I
L
-------------------
T
A
-------
A
E
K
L
K
K
V
L
S
A
N
T
N
--------------------
A
-
P
F
S
V
--
E
S
V
MN----
D
--
V
D
-
V
S
S
Q
L
S
-
R
E
E
L
---
E
E
L
V
K
P
L
------
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
KL--
S
A
E
---
E
V
D
F
---------
V
----
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
K
-
P
---
L
S
T
----------------------------
T
L
-
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
-----
A
I
H
S
P
T
L
R
V
R
--
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
Q
V
E
47
Fugue
53.38
13%
-68
- C4 -
2CGL
3
RHAB_ECOLI
A:
[2-480]
---------
T
F
R
N
C
V
A
V
D
L
G
AS
S
G
R
V
M
L
A
R
Y
E
R
E
C
R
S
L
T
L
R
E
I
H
R
F
N
N
G
L
H
S
Q
N
G
Y
V
T
-
W
D
-
V
D
S
L
E
S
A
I
R
L
G
L
N
K
V
C
A
-
A
G
I
A
I
D
---
S
I
G
I
D
T
W
G
--
V
D
F
-
V
L
L
D
Q
Q
G
Q
R
-
V
GLP
V
A
---
Y
R
D
S
R
-
T
N
G
L
M
A
Q
A
Q
Q
Q
L
G
K
R
-
D
--
I
Y
-
Q
R
S
G
I
Q
F
L
P
FN
T
L
Y
Q
L
R
A
L
T
E
Q
Q
P
E
L
I
P
HIA
H
A
L
L
M
P
D
Y
F
S
Y
-
R
-
L
T
G
K
M
N
W
E
Y
T
N
A
T
T
---
T
----
Q
L
V
N
I
NSDDWD
E
S
L
L
A
W
S
GANKAWFGRPTHPGNVI
G
H
W
I
C
PQ
G
N
E
--
I
P
V
V
A
V
A
S
H
D
T
A
S
A
V
I
A
S
P
--
L
N
-----------
G
S
R
A
A
Y
L
S
S
G
T
W
S
L
M
G
F
E
S
QTP
F
--
T
N
D
T
A
-----
L
-----
A
--
A
N
I
T
N
EGGAE
G
R
Y
-
R
V
L
K
N
I
M
G
L
W
L
L
Q
R
-------------------
V
-------------------
L
Q
E
R
QIND
L
P
A
L
I
A
A
T
Q
A
L
P
A
C
R
F
IINPNDDRF
I
N
P
D
-----
E
M
C
S
E
I
--
Q
A
A
------
C
--
R
E
M
A
Q
P
I
P
E
S
D
A
E
L
---
A
R
C
I
F
D
S
------
L
A
L
L
Y
A
D
V
L
H
E
L
A
Q
-----
L
R
G
E--
D
F
S
Q
---------
L
----
H
I
V
G
G
G
C
Q
N
T
L
L
N
Q
L
C
A
D
A
C
G
I
-
R
---
V
I
A
G
P
V
E
A
-
S
T
--
L
G
---
N
-------
I
--
G
I
Q
L
M
T
L
D
E
L
N
N
V
D
D
F
R
Q
V
-----
V
S
T
T
A
N
L
T
T
F
--
T
P
N
P
D
S
E
I
A
H
Y
V
A
L
I
H
S
----
36
HHSearch
51.83
17%
-68
- C4 -
3DWL
1
ARP3_SCHPO
A:
[135-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
---
E
----
N
R
E
N
T
------
A
E
I
M
F
E
-------------------------
S
F
N
--
C
A
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
W
T
--
S
S
KVT----
D
R
S
L
T
G
T
V
V
D
S
G
D
G
V
T
H
I
-
I
P
V
----
A
--
E
G
Y
V
I
-----
G
-----
S
SI
K
T
M
P
L
-----
A
G
R
-
D
V
T
Y
F
V
-
Q
S
L
L
R
---------------------
L
-------------------
K
T
-------
A
E
R
I
K
E
E
C
C
Y
V
C
P
D
I
---------
V
K
E
F
S
R
F
DR---
L
K
Y
AS-----------------
I
D
V
G
-
F
E
R
F
LAP
E
I
F
F
N
P
E
IASSDF
L
T
P
L
P
E
L
V
D
N
V
V
Q
S
SPIDV
R
K
G
---
L
Y
K
N
---------
I
----
V
L
S
G
G
S
T
L
F
K
N
F
G
N
R
L
Q
R
D
L
K
R
-
I
---
V
D
E
R
---
G
-
V
D
V
-
N
V
--------------
I
S
H
K
-
R
Q
R
N
A
V
W
F
G
G
S
L
L
A
-----
Q
T
P
E
F
G
S
Y
C
H
--
T
K
A
D
Y
E
E
Y
G
A
S
I
A
R
R
Y
Q
I
---
48
Fugue
49.70
21%
-31
* C2 *
3WL8
2
OPH_PSESP
A:
[23-358]
-----------------------
V
K
W
-
E
C
--------------
P
A
G
Y
E
V
K
E
G
L
N
V
-----
D
-
F
P
H
K
G
M
K
R
A
F
I
V
Y
P
A
K
N
V
S
G
P
--
A
---
P
V
W
V
P
M
T
G
--
S
V
E
S
T
N
D
N
L
T
V
A
R
-
S
---
G
A
---
N
S
I
L
A
-
D
H
G
Y
-------------------
T
V
I
A
---
P
------
V
R
A
C
A
N
Q
D
P
N
I
R
G
------
E
-
R
C
N
G
P
G
-
S
-
N
G
W
N
-
W
N
-
P
W
F
E
G
R
AAD
P
----
S
G
E
H
W
------
K
N
D
E
G
P
-------------------------
D
S
S
F
F
V
A
M
V
Q
C
V
G
T
K
Y
K
---------
L
D
-------
A
R
R
L
F
L
G
G
I
A
S
G
G
T
M
T
N
R
-
A
L
L
----
F
--
R
S
N
F
------
W
-----
A
--
G
G
L
P
I
-----
S
G
E
W
Y
V
T
S
D
----------------------------------------------------------------
D
G
T
P
L
--
S
---------
F
D
D
A
-----
R
-
A
A
V
A
--
A
A
P
------
T
--
K
I
-
H
Q
G
R
V
G
-
P
Y
P
L
---
P
A
K
V
G
P
L
------
I
V
M
T
V
W
G
G
E
K
D
L
W
N
-----
C
T
R
---
P
D
G
S
---------
R
----
F
L
C
A
D
---
Y
R
P
S
T
Q
A
G
S
N
F
F
S
A
-
Q
PD
V
V
H
V
A
C
S
S
T
-
H
G
--
H
M
---
W
-------
P
--
Q
L
N
T
-
Q
E
F
N
R
W
A
L
D
T
L
A
S
H
PKGSD
P
R
S
F
K
L
T
Q
P
P
EG
Y
T
C
H
V
G
P
F
T
G
L
Y
A
S
A
W
S
----
29
HHSearch
49.48
17%
-70
- C4 -
3QFU
3
GRP78_YEAST
A:
[167-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
Q
R
Q
A
T
------
K
D
A
G
T
--------------------------
I
A
G
--
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
--
D
K
S------
D
K
E
H
Q
I
I
V
Y
D
L
G
G
G
T
F
D
V
-
S
L
L
----
S
--
I
E
N
G
V
-----
F
EVQ
A
T
S
--
G
D
T
H
L
-----
G
G
E
-
D
F
D
Y
K
I
-
V
R
Q
L
I
K
A
-------------------
F
K
K
K
HGIDVSDN
N
K
A
L
A
K
L
K
R
E
-------
A
E
K
A
K
R
A
L
S
S
Q
M
S
--------------------
T
-
R
I
E
I
--
D
S
F
VD----
G
--
I
D
-
L
S
E
T
L
T
-
R
A
K
F
---
E
E
L
N
L
D
L
------
F
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
GL--
E
K
K
---
D
V
D
D
---------
I
----
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K
K
---
A
S
----------------------------
K
G
I
-
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
-----
G
V
L
S
-----------------------------
28
HHSearch
49.19
17%
-60
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[122-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
A
----
Q
R
Q
A
T
------
K
D
A
G
R
--------------------------
I
A
G
--
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
--
D
K
-------
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
-
S
I
L
----
E
--
L
G
D
G
V
F
E
V
K
A
T
-----
A
--
G
D
N
H
L
-----
G
G
D
-
D
F
D
Q
V
I
-
I
D
Y
L
V
N
Q
-------------------
F
K
Q
E
HGIDLSKD
K
M
A
L
Q
R
L
K
D
A
-------
A
E
K
A
K
K
E
L
S
G
V
T
Q
--------------------
T
-
Q
I
S
L
--
P
F
I
SANEN
G
P
--
L
H
-
L
E
M
T
L
T
-
R
A
K
F
---
E
E
L
S
A
H
L
------
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
GL--
T
P
A
---
D
I
D
K
---------
V
----
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
-
E
---
P
H
K
----------------------------
G
V
-
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
-----
G
V
I
A
G
E
V
K
D
V
--
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K