@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0113: (2016-03-12 )
MNREMLYLNRSDIEQAGGNHSQVYVDALTEALTAHAHNDFVQPLKPYLRQDPENGHIADRIIAMPSHIGGEHAISGIKWIGSKHDNPSKRNMERASGVIILNDPETNYPIAVMEASLISSMRTAAVSVIAAKHLAKKGFKDLTIIGCGLIGDKQLQSMLEQFDHIKRVFVYDQFSEACARFVDRWQQQRPEINFIATENAKEAVSNGEVVITCTVTDQPYIEYDWLQKGAFISNISIMDVHKEVFIKADKVVVDDWSQCNREKKTINQLVLEGKFSKEALHAELGQLVTGDIPGREDDDEIILLNPMGMAIEDISSAYFIYQQAQQQNIGTTLNLY
Atome Classification :
(20 SA)
.........10.-.....-----..20...--.....30.---.......40--.........50........60...-.....70........80........90.....-...100.......110.......120.......-130.......140-.......150.......160.......170...--....180.......190.......200.......210.....--..220-......-...230....-----..-------.---------.240-.----.......250.......260.......270..-----------.....280.......290.......300.......310.......320......-.330....-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNR
E
M
L
Y
L
N
R
S
D
-
I
E
Q
AG-----GNH
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
HAHN
D
F
---
V
Q
P
L
K
P
Y
L
RQDPENGH
I
A
D
R
I
I
AM-PSHIG
G
E
H
A
I
S
G
I
K
WIGSKHDNPSKRNMERAS-
G
V
I
I
L
NDPETNY
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
KGFK
D
L
-
T
I
I
G
CGLIG
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
K
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
QRP
E
I
N
F
I
ATE
N
A
K
E
AVSNG
E
V
V
I
T
C
TVTD--QP
Y
---
I
E
Y
D
W
L-QKGA-FISN
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
KAD
K
V
V
VD
D
W
S
Q
C
N
R
E
K
K
T
I
N
Q
L
V
LEGK-----------F
S
K
E
A
L
H
A
E
L
G
Q
L
V
TGDIPGREDDD
E
I
I
L
LNPMG
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
QQN-IGTTLNLY-----------------
2
PsiBlast_PDB
97.39
99%
-111
- C2 -
4MP8
2
?
A:
[6-339]
--
R
E
M
L
Y
L
N
R
S
D
-
I
E
Q
A
G
-----
G
N
H
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
H
A
H
N
D
F
---
V
Q
P
L
K
P
Y
L
R
Q
D
P
E
N
G
H
I
A
D
R
I
I
A
M
-
P
S
H
I
G
G
E
H
A
I
S
G
I
K
W
I
G
S
K
H
D
N
P
S
K
R
N
M
E
R
A
S
-
G
V
I
I
L
N
D
P
E
T
N
Y
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
K
G
F
K
D
L
-
T
I
I
G
C
G
L
I
G
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
E
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
Q
R
P
E
I
N
F
I
A
T
E
N
A
K
E
A
V
S
N
G
E
V
V
I
T
C
T
V
T
D
--
Q
P
Y
---
I
E
Y
D
W
L
-
Q
K
G
A
-
F
I
S
N
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
K
A
D
K
V
V
V
D
D
W
S
Q
C
N
R
E
K
K
T
I
N
Q
L
V
L
E
G
K
-----------
F
S
K
E
A
L
H
A
E
L
G
Q
L
V
T
G
D
I
P
G
R
E
D
D
D
E
I
I
L
L
N
P
M
G
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
Q
Q
N
-
I
G
T
T
L
N
L
Y
-----------------
3
PsiBlast_PDB
96.93
99%
-117
- C2 -
4MPD
2
?
A:
[6-339]
--
R
E
M
L
Y
L
N
R
S
D
-
I
E
Q
A
G
-----
G
N
H
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
H
A
H
N
D
F
---
V
Q
P
L
K
P
Y
L
R
Q
-------
A
D
R
I
I
A
M
-
P
S
H
I
-----
I
S
G
I
K
W
I
G
S
K
H
D
N
P
S
K
R
N
M
E
R
A
S
-
G
V
I
I
L
N
D
P
E
T
N
Y
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
K
G
F
K
D
L
-
T
I
I
G
C
G
L
I
G
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
E
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
Q
R
P
E
I
N
F
I
A
T
E
N
A
K
E
A
V
S
N
G
E
V
V
I
T
C
T
V
T
D
--
Q
P
Y
---
I
E
Y
D
W
L
-
Q
K
G
A
-
F
I
S
N
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
K
A
D
K
V
V
V
D
D
W
S
Q
C
N
----
T
I
N
Q
L
V
L
E
G
K
-----------
F
S
K
E
A
L
H
A
E
L
G
Q
L
V
T
G
D
I
P
G
R
E
D
D
D
E
I
I
L
L
N
P
M
G
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
Q
Q
N
-
I
G
T
T
L
N
L
Y
-----------------
1
PsiBlast_PDB
96.84
99%
-110
- C2 -
4MP6
2
?
A:
[6-339]
--
R
E
M
L
Y
L
N
R
S
D
-
I
E
Q
A
G
-----
G
N
H
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
H
A
H
N
D
F
---
V
Q
P
L
K
P
Y
L
R
Q
D
P
E
N
G
H
I
A
D
R
I
I
A
M
-
P
S
H
I
G
G
E
H
A
I
S
G
I
K
W
I
G
S
K
H
D
N
P
S
K
R
N
M
E
R
A
S
-
G
V
I
I
L
N
D
P
E
T
N
Y
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
K
G
F
K
D
L
-
T
I
I
G
C
G
L
I
G
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
E
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
Q
R
P
E
I
N
F
I
A
T
E
N
A
K
E
A
V
S
N
G
E
V
V
I
T
C
T
V
T
D
--
Q
P
Y
---
I
E
Y
D
W
L
-
Q
K
G
A
-
F
I
S
N
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
K
A
D
K
V
V
V
D
D
W
S
Q
C
N
R
E
K
K
T
I
N
Q
L
V
L
E
G
K
-----------
F
S
K
E
A
L
H
A
E
L
G
Q
L
V
T
G
D
I
P
G
R
E
D
D
D
E
I
I
L
L
N
P
M
G
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
Q
Q
N
-
I
G
T
T
L
N
L
Y
-----------------
5
PsiBlast_PDB
96.55
97%
-111
- C2 -
4MP3
3
?
A:
[5-339]
-
N
R
E
M
L
Y
L
N
R
S
D
-
I
E
Q
A
G
-----
G
N
H
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
H
A
H
N
D
F
---
V
Q
P
L
K
P
Y
L
R
Q
-----
H
I
A
D
R
I
I
A
M
-
P
S
H
I
G
G
E
H
A
I
S
G
I
K
W
I
G
S
K
H
D
N
P
S
K
R
N
M
E
R
A
S
-
G
V
I
I
L
N
D
P
E
T
N
Y
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
K
G
F
K
D
L
-
T
I
I
G
C
G
L
I
G
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
E
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
Q
R
P
E
I
N
F
I
A
T
E
N
A
K
E
A
V
S
N
G
E
V
V
I
T
C
T
V
T
D
--
Q
P
Y
---
I
E
Y
D
W
L
-
Q
K
G
A
-
F
I
S
N
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
K
A
D
K
V
V
V
D
D
W
S
Q
C
N
R
E
K
K
T
I
N
Q
L
V
L
E
G
K
-----------
F
S
K
E
A
L
H
A
E
L
G
Q
L
V
T
G
D
I
P
G
R
E
D
D
D
E
I
I
L
L
N
P
M
G
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
Q
Q
N
-
I
G
T
T
L
N
L
Y
-----------------
4
PsiBlast_PDB
93.99
99%
-113
- C2 -
4M54
3
?
A:
[6-339]
--
R
E
M
L
Y
L
N
R
S
D
-
I
E
Q
A
G
-----
G
N
H
S
Q
V
Y
--
V
D
A
L
T
E
A
L
---
T
A
H
A
H
N
D
F
---
V
Q
P
L
K
P
Y
L
R
Q
-----
H
I
A
D
R
I
I
A
M
-
P
S
H
I
G
G
E
H
A
I
S
G
I
K
W
I
G
S
K
H
D
N
P
S
K
R
N
M
E
R
A
S
-
G
V
I
I
L
N
D
P
E
T
N
Y
P
I
A
V
M
E
A
S
L
I
S
S
M
R
T
A
A
V
S
V
I
-
A
A
K
H
L
A
K
K
G
F
K
D
L
-
T
I
I
G
C
G
L
I
G
D
K
Q
L
Q
S
M
L
E
Q
F
D
H
I
E
R
V
F
V
Y
D
Q
F
S
--
E
A
C
A
R
F
V
D
R
W
Q
Q
Q
R
P
E
I
N
F
I
A
T
E
N
A
K
E
A
V
S
N
G
E
V
V
I
T
C
T
V
T
D
--
Q
P
Y
---
I
E
Y
D
W
L
-
Q
K
G
A
-
F
I
S
N
I
-----
S
I
-------
M
---------
D
V
H
--
K
----
E
V
F
I
K
A
D
K
V
V
V
D
D
W
S
Q
C
N
------------------------------
L
H
A
E
L
G
Q
L
V
T
G
D
I
P
G
R
E
D
D
D
E
I
I
L
L
N
P
M
G
M
A
I
E
D
I
S
S
A
Y
F
I
Y
Q
Q
A
Q
Q
Q
N
-
I
G
T
T
L
N
L
Y
-----------------
19
HHSearch
72.01
32%
-98
- C2 -
1OMO
2
ALADH_ARCFU
A:
[1-320]
--
M
E
T
L
I
L
T
Q
E
E
-
V
E
S
L
I
-------
S
M
D
E
A
--
M
N
A
V
E
E
A
F
---
R
L
Y
A
L
G
K
A
---
Q
M
P
P
K
V
Y
L
E
F
E
------
K
G
D
L
R
A
M
-
P
A
H
L
M
---
G
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
-
K
G
L
P
T
V
M
-
A
L
M
I
L
N
S
P
E
T
G
F
P
L
A
V
M
D
A
T
Y
T
T
S
L
R
T
G
A
A
G
G
I
-
A
A
K
Y
L
A
R
K
N
S
S
V
F
-
G
F
I
G
C
G
T
Q
A
Y
F
Q
L
E
A
L
R
R
V
F
-
D
I
G
E
V
K
A
Y
D
V
R
E
--
K
A
A
K
K
F
V
S
Y
C
E
D
R
--
G
--
I
S
A
S
V
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
P
S
R
--
K
P
V
---
V
K
A
E
W
V
-
E
E
G
T
-
H
I
N
A
I
-----
G
A
DGPGK--
Q
---------
E
L
D
--
V
----
E
I
L
K
K
A
-
K
I
V
V
D
D
L
E
Q
A
K
H
G
-
G
E
I
N
V
A
V
S
K
G
V
-----------
I
G
V
E
D
V
H
A
T
I
G
E
V
I
A
G
L
K
D
G
R
E
S
D
E
E
I
T
I
F
D
S
T
G
L
A
I
Q
D
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
-
V
G
S
K
I
K
F
F
-----------------
7
PsiBlast_PDB
70.95
32%
-91
- C2 -
1VLL
-
ALADH_ARCFU
A:
[21-320]
--------------------------------
M
N
A
V
E
E
A
F
---
R
L
Y
A
L
G
K
A
---
Q
M
P
P
K
V
Y
L
--
E
F
E
K
G
D
L
R
----
A
M
-
P
A
H
L
M
G
---
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
K
-
G
L
P
T
V
M
-
A
L
M
I
L
N
S
P
E
T
G
F
P
L
A
V
M
D
A
T
Y
T
T
S
L
R
T
G
A
A
G
G
I
-
A
A
K
Y
L
A
R
K
N
S
S
V
F
-
G
F
I
G
C
G
T
Q
A
Y
F
Q
L
E
A
L
R
R
V
F
D
-
I
G
E
V
K
A
Y
D
V
R
E
--
K
A
A
K
K
F
V
S
Y
C
E
D
R
----
G
I
S
A
S
V
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
P
S
R
--
K
P
V
---
V
K
A
E
W
V
-
E
E
G
T
-
H
I
N
A
I
-----
G
A
DGPGKQE
L
---------
D
V
E
---------
I
L
K
K
A
K
I
V
V
D
D
L
E
Q
A
-
K
H
G
G
E
I
N
V
A
V
S
K
G
V
-----------
I
G
V
E
D
V
H
A
T
I
G
E
V
I
A
G
L
K
D
G
R
E
S
D
E
E
I
T
I
F
D
S
T
G
L
A
I
Q
D
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
-
V
G
S
K
I
K
F
F
-----------------
39
Fugue
70.87
32%
-87
- C2 -
1OMO
2
ALADH_ARCFU
A:
[1-320]
--
M
E
T
L
I
L
T
Q
E
E
-
V
E
S
L
-------
I
S
M
D
E
A
--
M
N
A
V
E
E
A
F
---
R
L
Y
A
L
G
K
A
---
Q
M
P
P
K
V
Y
L
E
F
E
K
------
G
D
L
R
A
M
-
P
A
H
L
M
G
---
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
K
-
G
L
P
T
V
M
-
A
L
M
I
L
N
S
P
E
T
G
F
P
L
A
V
M
D
A
T
Y
T
T
S
L
R
T
G
A
A
G
G
I
-
A
A
K
Y
L
A
R
K
N
S
S
V
F
-
G
F
I
G
C
G
T
Q
A
Y
F
Q
L
E
A
L
R
R
V
F
D
-
I
G
E
V
K
A
Y
D
V
R
E
--
K
A
A
K
K
F
V
S
Y
C
E
D
R
G
I
S
----
A
S
V
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
P
S
R
--
K
P
V
---
V
K
A
E
W
V
-
E
E
G
T
-
H
I
N
A
I
-----
G
A
-------
D
---------
G
P
G
--
K
QELD
V
E
I
L
K
K
A
K
I
V
V
D
D
L
E
Q
A
K
H
G
G
-
E
I
N
V
A
V
S
K
G
V
-----------
I
G
V
E
D
V
H
A
T
I
G
E
V
I
A
G
L
K
D
G
R
E
S
D
E
E
I
T
I
F
D
S
T
G
L
A
I
Q
D
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
-
V
G
S
K
I
K
F
F
-----------------
18
PsiBlast_CBE
70.65
32%
-92
- C2 -
1OMO
2
ALADH_ARCFU
B:
[21-320]
--------------------------------
M
N
A
V
E
E
A
F
---
R
L
Y
A
L
G
K
A
---
Q
M
P
P
K
V
Y
L
--
E
F
E
K
G
D
L
R
----
A
M
-
P
A
H
L
M
G
---
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
K
-
G
L
P
T
V
M
-
A
L
M
I
L
N
S
P
E
T
G
F
P
L
A
V
M
D
A
T
Y
T
T
S
L
R
T
G
A
A
G
G
I
-
A
A
K
Y
L
A
R
K
N
S
S
V
F
-
G
F
I
G
C
G
T
Q
A
Y
F
Q
L
E
A
L
R
R
V
F
D
-
I
G
E
V
K
A
Y
D
V
R
E
--
K
A
A
K
K
F
V
S
Y
C
E
D
R
----
G
I
S
A
S
V
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
P
S
R
--
K
P
V
---
V
K
A
E
W
V
-
E
E
G
T
-
H
I
N
A
I
-----
G
A
DGPGKQE
L
---------
D
V
E
---------
I
L
K
K
A
K
I
V
V
D
D
L
E
Q
A
-
K
H
G
G
E
I
N
V
A
V
S
K
G
V
-----------
I
G
V
E
D
V
H
A
T
I
G
E
V
I
A
G
L
K
D
G
R
E
S
D
E
E
I
T
I
F
D
S
T
G
L
A
I
Q
D
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
-
V
G
S
K
I
K
F
F
-----------------
6
PsiBlast_PDB
70.17
32%
-94
- C2 -
1OMO
2
ALADH_ARCFU
A:
[21-320]
--------------------------------
M
N
A
V
E
E
A
F
---
R
L
Y
A
L
G
K
A
---
Q
M
P
P
K
V
Y
L
--
E
F
E
K
G
D
L
R
----
A
M
-
P
A
H
L
M
G
---
Y
A
G
L
K
W
V
N
S
H
P
G
N
P
D
K
-
G
L
P
T
V
M
-
A
L
M
I
L
N
S
P
E
T
G
F
P
L
A
V
M
D
A
T
Y
T
T
S
L
R
T
G
A
A
G
G
I
-
A
A
K
Y
L
A
R
K
N
S
S
V
F
-
G
F
I
G
C
G
T
Q
A
Y
F
Q
L
E
A
L
R
R
V
F
D
-
I
G
E
V
K
A
Y
D
V
R
E
--
K
A
A
K
K
F
V
S
Y
C
E
D
R
----
G
I
S
A
S
V
Q
P
A
E
E
A
S
R
C
D
V
L
V
T
T
T
P
S
R
--
K
P
V
---
V
K
A
E
W
V
-
E
E
G
T
-
H
I
N
A
I
-----
G
A
DGPGKQE
L
---------
D
V
E
---------
I
L
K
K
A
K
I
V
V
D
D
L
E
Q
A
-
K
H
G
G
E
I
N
V
A
V
S
K
G
V
-----------
I
G
V
E
D
V
H
A
T
I
G
E
V
I
A
G
L
K
D
G
R
E
S
D
E
E
I
T
I
F
D
S
T
G
L
A
I
Q
D
V
A
V
A
K
V
V
Y
E
N
A
L
S
K
N
-
V
G
S
K
I
K
F
F
-----------------
20
HHSearch
69.33
22%
-90
* C2 *
1X7D
7
?
A:
[2-322]
----
T
Y
F
I
D
V
P
T
-
M
S
D
L
V
H
D
I
G
V
A
P
F
I
G
E
L
--
A
A
A
L
R
D
D
F
---
K
R
W
Q
A
F
D
-----
K
S
A
R
V
A
S
H
S
------
E
V
G
V
I
E
L
M
-
P
V
A
D
K
---
S
R
Y
A
F
K
Y
V
N
G
H
P
A
N
T
A
-
R
N
L
H
T
V
M
-
A
F
G
V
L
A
D
V
D
S
G
Y
P
V
L
L
S
E
L
T
I
A
T
A
L
R
T
A
A
T
S
L
M
-
A
A
Q
A
L
A
R
P
N
A
R
K
M
-
A
L
I
G
N
G
A
Q
S
E
F
Q
A
L
A
F
H
K
H
L
-
G
I
E
E
I
V
A
Y
D
T
D
P
--
L
A
T
A
K
L
I
A
N
L
K
E
Y
S
-
G
L
T
I
R
R
A
S
S
V
A
E
A
V
K
G
V
D
I
I
T
T
V
T
A
D
K
AY
A
T
I
---
I
T
P
D
M
L
-
E
P
G
M
-
H
L
N
A
V
-----
G
G
DCPGK--
T
---------
E
L
H
--
A
----
D
V
L
R
N
A
-
R
V
F
V
E
Y
E
P
Q
T
R
I
E
-
G
E
I
Q
Q
L
P
A
-----------------
D
F
P
V
V
D
L
W
R
V
L
R
G
E
T
E
G
R
Q
S
D
S
Q
V
T
V
F
D
S
V
G
F
A
L
E
D
Y
T
V
L
R
Y
V
L
Q
Q
A
E
K
R
G
-
M
G
T
K
I
D
L
------------------
8
PsiBlast_PDB
64.69
23%
-80
- C2 -
2I99
1
CRYM_HUMAN
A:
[1-306]
-
S
R
V
P
A
F
L
S
A
A
E
-
V
E
E
H
L
------
R
S
S
S
L
L
--
I
P
P
L
E
T
A
L
A
N
F
S
S
G
P
E
G
G
V
---
M
Q
P
V
R
T
V
V
P
V
T
K
H
R
G
Y
L
G
----
V
M
-
P
A
Y
S
A
A
E
D
A
L
T
-
T
K
L
V
T
F
Y
E
D
R
G
I
T
S
V
V
P
S
H
Q
-
A
T
V
L
L
F
E
P
S
N
G
T
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
-
A
T
K
F
L
K
P
P
S
S
E
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
-
F
K
E
V
R
I
W
N
R
T
K
--
E
N
A
E
K
F
A
D
T
V
Q
G
E
-----
V
R
V
C
S
S
V
Q
E
A
V
A
G
A
D
V
I
I
T
V
T
L
A
T
--
E
P
I
---
L
F
G
E
W
V
-
K
P
G
A
-
H
I
N
A
V
-----
G
A
-------
S
RPDWRELD
D
E
L
M
--
K
----
E
A
V
L
Y
V
D
-------
S
Q
E
A
A
L
K
E
S
G
D
V
L
----------------
L
S
G
A
E
I
F
A
E
L
G
E
V
I
K
G
V
K
P
A
H
--
C
E
K
T
T
V
F
K
S
L
G
M
A
V
E
D
T
V
A
A
K
L
I
Y
---------------------------------
42
Fugue
64.34
24%
-86
- C2 -
4BVA
3
CRYM_MOUSE
A:
[24-334]
-
K
R
A
P
A
F
L
S
A
E
E
-
V
Q
D
H
L
------
R
S
S
S
L
L
--
I
P
P
L
E
A
A
L
---
A
N
F
S
K
G
P
D
GG
V
M
Q
P
V
R
T
V
V
P
V
A
K
H
R
G
F
L
G
--
V
M
P
A
-
Y
S
A
A
E
D
A
L
T
T
K
L
V
T
F
Y
------------
E
S
H
Q
-
A
S
V
L
L
F
D
P
S
N
G
S
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
-
A
T
K
L
L
K
P
P
G
S
D
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
-
F
K
E
V
R
M
W
N
R
T
R
--
E
N
A
E
K
F
A
S
T
V
Q
G
-----
D
V
R
V
C
S
S
V
Q
E
A
V
T
G
A
D
V
I
I
T
V
T
M
A
T
--
E
P
I
---
L
F
G
E
W
V
-
K
P
G
A
-
H
I
N
A
V
GA---
S
R
-------
P
---------
D
W
R
EL
D
----
D
E
L
M
R
Q
A
V
L
Y
V
D
S
R
E
A
A
L
K
E
S
-------
G
D
V
L
-----------
L
S
G
A
D
I
F
A
E
L
G
E
V
I
S
G
A
K
P
A
H
C
E
K
T
--
T
V
F
K
S
L
G
M
A
V
E
D
L
V
A
A
K
L
V
Y
D
S
W
S
S
G
---------------------------
13
PsiBlast_PDB
64.33
23%
-97
- C2 -
1X7D
5
?
A:
[74-322]
--------------------------------------------------------------------------------------------------
H
P
A
N
T
A
R
N
L
H
T
V
M
-
A
F
G
V
L
A
D
V
D
S
G
Y
P
V
L
L
S
E
L
T
I
A
T
A
L
R
T
A
A
T
S
L
M
-
A
A
Q
A
L
A
R
P
N
A
R
K
M
-
A
L
I
G
N
G
A
Q
S
E
F
Q
A
L
A
F
H
K
H
L
G
-
I
E
E
I
V
A
Y
D
T
D
P
--
L
A
T
A
K
L
I
A
N
L
K
E
Y
S
-
G
L
T
I
R
R
A
S
S
V
A
E
A
V
K
G
V
D
I
I
T
T
V
T
-
A
D
--
K
A
Y
ATI
I
T
P
D
M
L
-
E
P
G
M
-
H
L
N
A
V
GGDCP
G
K
-------
T
---------
E
L
H
--
A
----
D
V
L
R
N
A
R
V
F
V
--
E
Y
E
P
Q
T
R
I
E
G
E
I
Q
Q
L
P
A
D
F
P
-----------
V
------
V
D
L
W
R
V
L
R
G
E
T
E
G
R
Q
S
D
S
Q
V
T
V
F
D
S
V
G
F
A
L
E
D
Y
T
V
L
R
Y
V
L
Q
Q
A
E
K
R
G
-
M
G
T
K
I
D
L
------------------
12
PsiBlast_PDB
63.98
23%
-99
- C2 -
1U7H
3
?
A:
[74-322]
--------------------------------------------------------------------------------------------------
H
P
A
N
T
A
R
N
L
H
T
V
M
-
A
F
G
V
L
A
D
V
D
S
G
Y
P
V
L
L
S
E
L
T
I
A
T
A
L
R
T
A
A
T
S
L
M
-
A
A
Q
A
L
A
R
P
N
A
R
K
M
-
A
L
I
G
N
G
A
Q
S
E
F
Q
A
L
A
F
H
K
H
L
G
-
I
E
E
I
V
A
Y
D
T
D
P
--
L
A
T
A
K
L
I
A
N
L
K
E
Y
S
-
G
L
T
I
R
R
A
S
S
V
A
E
A
V
K
G
V
D
I
I
T
T
V
T
-
A
D
--
K
A
Y
ATI
I
T
P
D
M
L
-
E
P
G
M
-
H
L
N
A
V
GGDCP
G
K
-------
T
---------
E
L
H
--
A
----
D
V
L
R
N
A
R
V
F
V
--
E
Y
E
P
Q
T
R
I
E
G
E
I
Q
Q
L
P
A
D
F
P
-----------
V
------
V
D
L
W
R
V
L
R
G
E
T
E
G
R
Q
S
D
S
Q
V
T
V
F
D
S
V
G
F
A
L
E
D
Y
T
V
L
R
Y
V
L
Q
Q
A
E
K
R
G
-
M
G
T
K
I
D
L
------------------
40
Fugue
63.79
22%
-76
- C2 -
2I99
1
CRYM_HUMAN
A:
[1-312]
-
S
R
V
P
A
F
L
S
A
A
E
-
V
E
E
H
L
-----
R
S
S
S
L
L
I
P
P
L
E
T
A
L
A
N
F
---
S
S
G
P
E
G
G
V
---
M
Q
P
V
R
T
V
V
P
V
T
K
H
R
G
Y
L
G
V
M
P
A
Y
S
-
A
A
E
-----
D
A
L
T
T
K
L
V
T
F
Y
E
D
R
G
I
T
S
V
V
P
S
H
Q
-
A
T
V
L
L
F
E
P
S
N
G
T
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
-
A
T
K
F
L
K
P
P
S
S
E
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
-
F
K
E
V
R
I
W
N
R
T
K
--
E
N
A
E
K
F
A
D
T
-----
V
Q
G
E
V
R
V
C
S
S
V
Q
E
A
V
A
G
A
D
V
I
I
T
V
T
L
A
T
--
E
P
I
---
L
F
G
E
W
V
-
K
P
G
A
-
H
I
N
A
V
-----
G
A
-------
S
---------
R
P
D
--
W
RELD
D
E
L
M
K
E
A
V
L
Y
V
D
S
Q
E
A
A
L
K
E
S
G
D
V
L
L
------------------
S
G
A
E
I
F
A
E
L
G
E
V
I
K
G
V
K
P
A
H
--
C
E
K
T
T
V
F
K
S
L
G
M
A
V
E
D
T
V
A
A
K
L
I
Y
D
S
W
S
S
G
---------------------------
41
Fugue
63.13
17%
-72
- C2 -
1X7D
9
?
A:
[2-341]
----
T
Y
F
I
D
V
P
T
M
S
D
L
V
H
-----
D
I
G
V
A
P
F
--
I
G
E
L
A
A
A
L
---
R
D
D
F
K
R
--------
W
Q
A
F
D
K
S
A
R
V
A
S
H
S
E
V
G
V
I
E
L
M
P
V
A
D
K
S
---
R
Y
A
F
K
Y
V
N
G
H
P
A
N
T
A
R
N
L
--
H
T
V
M
A
F
G
V
L
A
D
V
D
S
G
Y
P
V
L
L
S
E
L
T
I
A
T
A
L
R
T
A
A
T
S
L
-
M
A
A
Q
A
L
A
R
P
N
A
R
-
K
M
A
L
I
G
N
G
A
Q
S
E
F
Q
A
L
A
F
H
K
H
L
G
-
I
E
E
I
V
A
Y
D
T
D
P
--
L
A
T
A
K
L
I
A
N
L
K
E
Y
-
S
G
L
T
I
R
R
A
S
S
V
A
E
A
V
K
G
V
D
I
I
T
T
V
T
A
D
K
--
A
Y
A
---
T
I
I
T
P
D
M
L
E
P
G
M
H
L
N
A
V
-----
G
G
DCPGK--
T
---------
E
L
H
--
A
----
D
V
L
R
N
A
-
R
V
F
V
E
Y
E
P
Q
T
R
I
E
G
E
I
Q
Q
------------------
L
P
A
D
F
P
V
V
D
L
W
R
V
L
R
G
E
T
E
G
R
Q
S
D
S
Q
V
T
V
F
D
S
V
G
F
A
L
E
D
Y
T
V
L
R
Y
V
L
Q
Q
A
E
K
R
G
M
G
T
K
I
D
L
V
P
WVEDDPKD
L
F
S
H
T
RGRA
21
HHSearch
62.32
22%
-92
- C2 -
3HDJ
7
?
A:
[3-308]
---
A
M
L
H
I
D
D
A
M
-
I
E
D
A
V
-------
T
P
Q
A
A
--
Q
E
V
L
H
A
A
F
---
L
D
F
G
R
G
S
A
---
A
M
Q
R
R
V
R
T
E
A
------
G
G
V
K
L
S
T
L
-
G
A
V
I
P
G
-
Q
G
V
A
G
A
K
V
Y
T
T
I
K
G
Q
F
--------
Q
-
F
V
I
L
L
F
S
A
A
D
G
R
P
L
A
T
C
D
A
G
T
L
T
R
K
R
T
A
A
C
T
V
L
-
A
A
G
A
L
A
R
P
R
S
S
V
L
-
G
L
F
G
A
G
T
Q
G
A
E
H
A
A
Q
L
S
A
R
F
-
A
L
E
A
I
L
V
H
D
P
Y
A
S
P
E
I
L
E
R
I
G
R
R
C
-----
G
V
P
A
-
R
M
A
A
P
A
D
I
A
A
Q
A
D
I
V
V
T
A
T
R
S
T
--
T
P
L
---
F
A
G
Q
A
L
-
R
A
G
A
-
F
V
G
A
I
-----
G
S
SLPHT--
R
---------
E
L
D
--
D
----
E
A
L
R
R
A
R
A
V
V
V
E
W
R
E
Q
T
L
S
E
A
G
D
L
V
L
A
A
P
D
T
G
-----------
L
--
D
A
K
V
V
E
L
A
D
V
L
A
G
R
A
A
A
R
Q
A
D
E
D
I
V
I
Y
K
S
V
G
V
G
L
E
D
V
A
L
A
G
Y
A
Y
R
R
L
A
A
Q
R
--------------------------
11
PsiBlast_PDB
56.68
24%
-93
- C2 -
4BVA
3
CRYM_MOUSE
A:
[84-328]
-----------------------------------------------------------------------------
M
-
P
A
Y
S
A
A
E
D
A
L
T
-
T
K
L
V
-
T
F
Y
E
--------
S
H
Q
-
A
S
V
L
L
F
D
P
S
N
G
S
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
-
A
T
K
L
L
K
P
P
G
S
D
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
-
F
K
E
V
R
M
W
N
R
T
R
--
E
N
A
E
K
F
A
S
T
V
Q
G
-----
D
V
R
V
C
S
S
V
Q
E
A
V
T
G
A
D
V
I
I
T
V
T
M
A
T
--
E
P
I
---
L
F
G
E
W
V
-
K
P
G
A
-
H
I
N
A
V
-----
G
A
-------
S
---------
R
--------------------
P
D
W
R
E
L
D
D
E
L
M
R
Q
A
V
L
Y
V
D
S
R
E
A
A
L
K
ES
G
D
V
L
L
S
G
A
D
I
F
A
E
L
G
E
V
I
S
G
A
K
P
A
H
--
C
E
K
T
T
V
F
K
S
L
G
M
A
V
E
D
L
V
A
A
K
L
V
Y
---------------------------------
9
PsiBlast_PDB
56.01
24%
-88
- C2 -
4BV8
1
CRYM_MOUSE
A:
[84-328]
-----------------------------------------------------------------------------
M
-
P
A
Y
S
A
A
E
D
A
L
T
-
T
K
L
V
-
T
F
Y
E
-------
P
S
H
Q
-
A
S
V
L
L
F
D
P
S
N
G
S
L
L
A
V
M
D
G
N
V
I
T
A
K
R
T
A
A
V
S
A
I
-
A
T
K
L
L
K
P
P
G
S
D
V
L
-
C
I
L
G
A
G
V
Q
A
Y
S
H
Y
E
I
F
T
E
Q
F
S
-
F
K
E
V
R
M
W
N
R
T
R
--
E
N
A
E
K
F
A
S
T
V
Q
G
-----
D
V
R
V
C
S
S
V
Q
E
A
V
T
G
A
D
V
I
I
T
V
T
M
A
T
--
E
P
I
---
L
F
G
E
W
V
-
K
P
G
A
-
H
I
N
A
V
-----
G
A
-------
S
---------
R
--------------------
P
D
W
R
E
L
D
D
E
L
M
R
Q
A
V
L
Y
V
D
S
R
E
A
A
L
K
ES
G
D
V
L
L
S
G
A
D
I
F
A
E
L
G
E
V
I
S
G
A
K
P
A
H
--
C
E
K
T
T
V
F
K
S
L
G
M
A
V
E
D
L
V
A
A
K
L
V
Y
---------------------------------